CASD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)5.43699491
2presynaptic membrane organization (GO:0097090)5.06278782
3locomotory exploration behavior (GO:0035641)4.68286898
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.57826570
5synaptic vesicle maturation (GO:0016188)4.54644597
6lipopolysaccharide biosynthetic process (GO:0009103)4.50145579
7pyrimidine nucleobase catabolic process (GO:0006208)4.49094746
8vocalization behavior (GO:0071625)4.42221537
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.38486616
10regulation of glutamate receptor signaling pathway (GO:1900449)4.34154540
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.30650984
12synaptic vesicle exocytosis (GO:0016079)4.18869310
13lactate metabolic process (GO:0006089)4.16960811
14regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.12999960
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.12004684
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.03310827
17regulation of synaptic vesicle exocytosis (GO:2000300)4.00522922
18ionotropic glutamate receptor signaling pathway (GO:0035235)3.93467508
19glutamate secretion (GO:0014047)3.90468229
20exploration behavior (GO:0035640)3.86072406
21lipopolysaccharide metabolic process (GO:0008653)3.76037889
22neuron cell-cell adhesion (GO:0007158)3.75663384
23glutamate receptor signaling pathway (GO:0007215)3.72714115
24neurotransmitter secretion (GO:0007269)3.67903316
25nucleobase catabolic process (GO:0046113)3.64591736
26layer formation in cerebral cortex (GO:0021819)3.63720143
27protein localization to synapse (GO:0035418)3.63136153
28activation of protein kinase A activity (GO:0034199)3.56493435
29central nervous system projection neuron axonogenesis (GO:0021952)3.56140670
30regulation of long-term neuronal synaptic plasticity (GO:0048169)3.55191735
31synaptic vesicle docking involved in exocytosis (GO:0016081)3.55175452
32inner ear receptor cell development (GO:0060119)3.54807209
33regulation of synaptic vesicle transport (GO:1902803)3.50942231
34synaptic transmission, glutamatergic (GO:0035249)3.43210057
35regulation of respiratory system process (GO:0044065)3.41836961
36inner mitochondrial membrane organization (GO:0007007)3.39578377
37neurotransmitter-gated ion channel clustering (GO:0072578)3.37418978
38regulation of synapse structural plasticity (GO:0051823)3.36083905
39neuron-neuron synaptic transmission (GO:0007270)3.35614913
40behavioral response to nicotine (GO:0035095)3.30766251
41negative regulation of cytosolic calcium ion concentration (GO:0051481)3.30222301
42response to histamine (GO:0034776)3.25818291
43nonmotile primary cilium assembly (GO:0035058)3.25526107
44regulation of neuronal synaptic plasticity (GO:0048168)3.24330424
45neuron recognition (GO:0008038)3.22880456
46hindbrain development (GO:0030902)3.22167756
47G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.21211698
48gamma-aminobutyric acid signaling pathway (GO:0007214)3.20004010
49regulation of respiratory gaseous exchange (GO:0043576)3.19073939
50axonal fasciculation (GO:0007413)3.18515222
51limb bud formation (GO:0060174)3.13438791
52transmission of nerve impulse (GO:0019226)3.11601791
53positive regulation of synapse assembly (GO:0051965)3.11543372
54membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.10070367
55cell migration in hindbrain (GO:0021535)3.09539869
56regulation of dendritic spine morphogenesis (GO:0061001)3.09369409
57regulation of excitatory postsynaptic membrane potential (GO:0060079)3.08859973
58neuronal action potential propagation (GO:0019227)3.05376614
59auditory behavior (GO:0031223)3.05212324
60gamma-aminobutyric acid transport (GO:0015812)3.04628099
61establishment of nucleus localization (GO:0040023)3.04130558
62central nervous system neuron axonogenesis (GO:0021955)3.00643093
63regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.99874218
64neurotransmitter transport (GO:0006836)2.97605983
65catecholamine transport (GO:0051937)2.94594862
66cellular potassium ion homeostasis (GO:0030007)2.94542110
67dendritic spine morphogenesis (GO:0060997)2.93644504
68long-term memory (GO:0007616)2.89636060
69regulation of postsynaptic membrane potential (GO:0060078)2.88740808
70negative regulation of dendrite development (GO:2000171)2.88374772
71long-term synaptic potentiation (GO:0060291)2.87717780
72intraciliary transport (GO:0042073)2.87216135
73regulation of neurotransmitter levels (GO:0001505)2.86657321
74positive regulation of dendritic spine morphogenesis (GO:0061003)2.86008316
75cerebral cortex radially oriented cell migration (GO:0021799)2.85874583
76cerebellar Purkinje cell differentiation (GO:0021702)2.85751932
77positive regulation of synapse maturation (GO:0090129)2.85187350
78mating behavior (GO:0007617)2.84945130
79regulation of synaptic transmission, glutamatergic (GO:0051966)2.82781495
80dendrite morphogenesis (GO:0048813)2.81349848
81positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.79077368
82neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.79037639
83establishment of mitochondrion localization (GO:0051654)2.78733733
84mechanosensory behavior (GO:0007638)2.78080928
85G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.77046463
86regulation of dendritic spine development (GO:0060998)2.73839850
87female mating behavior (GO:0060180)2.73273661
88positive regulation of membrane potential (GO:0045838)2.72842716
89proline transport (GO:0015824)2.72555768
90response to pheromone (GO:0019236)2.71081661
91regulation of glucokinase activity (GO:0033131)2.70698350
92regulation of hexokinase activity (GO:1903299)2.70698350
93cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.70635939
94retinal ganglion cell axon guidance (GO:0031290)2.69445242
95regulation of female receptivity (GO:0045924)2.68059549
96calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.67500227
97behavioral response to cocaine (GO:0048148)2.66899371
98regulation of cAMP-dependent protein kinase activity (GO:2000479)2.66014647
99regulation of vesicle fusion (GO:0031338)2.65479944
100regulation of synaptic plasticity (GO:0048167)2.64608575
101negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.62774281
102cellular response to ammonium ion (GO:0071242)2.62638051
103neuron fate determination (GO:0048664)2.61863120
104embryonic retina morphogenesis in camera-type eye (GO:0060059)2.61107267
105regulation of synapse assembly (GO:0051963)2.59837151
106positive regulation of synaptic transmission, GABAergic (GO:0032230)2.59012055
107forebrain neuron differentiation (GO:0021879)2.58389746
108positive regulation of dendritic spine development (GO:0060999)2.58205867
109postsynaptic membrane organization (GO:0001941)2.57991120
110synapse organization (GO:0050808)2.57159209
111clathrin coat assembly (GO:0048268)2.57152380
112regulation of neurotransmitter secretion (GO:0046928)2.56355875
113cell communication by electrical coupling (GO:0010644)2.56244141
114negative regulation of synaptic transmission, GABAergic (GO:0032229)2.56029380
115behavioral defense response (GO:0002209)2.54851776
116behavioral fear response (GO:0001662)2.54851776
117regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.54390314
118neuronal action potential (GO:0019228)2.54166165
119suckling behavior (GO:0001967)2.53017388
120nucleus localization (GO:0051647)2.52811901
121adult walking behavior (GO:0007628)2.52718562
122neuromuscular process controlling balance (GO:0050885)2.52623369
123membrane depolarization (GO:0051899)2.52411170
124regulation of growth hormone secretion (GO:0060123)2.52393275
125response to auditory stimulus (GO:0010996)2.52159358
126glycerophospholipid catabolic process (GO:0046475)2.52144908
127adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.52055155
128somite development (GO:0061053)2.51176958
129positive regulation of vesicle fusion (GO:0031340)2.50829725
130neuron remodeling (GO:0016322)2.48407733
131positive regulation of neurotransmitter secretion (GO:0001956)2.47304491
132dopamine receptor signaling pathway (GO:0007212)2.47077284
133potassium ion import (GO:0010107)2.46170060
134synapse assembly (GO:0007416)2.45820474
135cell differentiation in hindbrain (GO:0021533)2.44883178
136negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.44178141
137membrane depolarization during action potential (GO:0086010)2.44172526
138cochlea development (GO:0090102)2.43678739
139peristalsis (GO:0030432)2.43140875
140regulation of neurotransmitter transport (GO:0051588)2.43004905
141innervation (GO:0060384)2.41349711
142somite rostral/caudal axis specification (GO:0032525)2.40791069
143dopamine biosynthetic process (GO:0042416)2.40520744
144neuromuscular synaptic transmission (GO:0007274)2.38140439
145epithelial cell differentiation involved in kidney development (GO:0035850)2.38006014
146olfactory bulb development (GO:0021772)2.33950873
147epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.33812692
148mitochondrion transport along microtubule (GO:0047497)2.33537136
149establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.33537136
150adult behavior (GO:0030534)2.32985936
151neuron migration (GO:0001764)2.32761148
152neuronal stem cell maintenance (GO:0097150)2.31998599
153negative regulation of astrocyte differentiation (GO:0048712)2.31651415

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.16128918
2GBX2_23144817_ChIP-Seq_PC3_Human3.19585803
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.84695556
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.83270376
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.79979117
6TAF15_26573619_Chip-Seq_HEK293_Human2.51622468
7SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47362471
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46209586
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46209586
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44518783
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41300959
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38582582
13IKZF1_21737484_ChIP-ChIP_HCT116_Human2.38372577
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37425923
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.25464285
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.22424573
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.18394786
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.16416332
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.11444655
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.10766862
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00654446
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.00446889
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.00341614
24DROSHA_22980978_ChIP-Seq_HELA_Human1.97625423
25* REST_21632747_ChIP-Seq_MESCs_Mouse1.96343860
26AR_21572438_ChIP-Seq_LNCaP_Human1.91567114
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.89744071
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.88221557
29ZNF274_21170338_ChIP-Seq_K562_Hela1.88171145
30SMAD4_21799915_ChIP-Seq_A2780_Human1.87596615
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86412929
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.84963681
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.79469240
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.78441979
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77806271
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77029999
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76672776
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.76632654
39P300_19829295_ChIP-Seq_ESCs_Human1.75854699
40* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.75854654
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73215090
42IGF1R_20145208_ChIP-Seq_DFB_Human1.68885247
43EWS_26573619_Chip-Seq_HEK293_Human1.67589616
44* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67231487
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.64264474
46FUS_26573619_Chip-Seq_HEK293_Human1.60577337
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.59931996
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59550383
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54611219
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.54218972
51VDR_22108803_ChIP-Seq_LS180_Human1.53649959
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.53197206
53TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.50957860
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.49804715
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.43001386
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42765051
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39654665
58* SOX2_21211035_ChIP-Seq_LN229_Gbm1.36844111
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36679860
60TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36387619
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36241771
62STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.35504146
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33726924
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33392393
65WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32251115
66MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31816454
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31732131
68EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31364074
69ESR1_20079471_ChIP-ChIP_T-47D_Human1.31002608
70* ER_23166858_ChIP-Seq_MCF-7_Human1.30697603
71ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29527078
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.29510568
73AR_25329375_ChIP-Seq_VCAP_Human1.29228099
74TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.27853135
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27656087
76EP300_21415370_ChIP-Seq_HL-1_Mouse1.25878007
77* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25223069
78P53_22387025_ChIP-Seq_ESCs_Mouse1.22517091
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.22001679
80RING1B_27294783_Chip-Seq_ESCs_Mouse1.21813061
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20995069
82E2F1_18555785_Chip-Seq_ESCs_Mouse1.20882573
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20770156
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20566559
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19787093
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19440129
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18568621
88CBP_20019798_ChIP-Seq_JUKART_Human1.18568621
89RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17664890
90WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17204466
91CBX2_27304074_Chip-Seq_ESCs_Mouse1.16614607
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16139444
93LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14780344
94RXR_22108803_ChIP-Seq_LS180_Human1.14719223
95SCL_19346495_ChIP-Seq_HPC-7_Human1.14544855
96RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14544029
97ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13820093
98NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13001765
99BCAT_22108803_ChIP-Seq_LS180_Human1.12940173
100AR_19668381_ChIP-Seq_PC3_Human1.12782120
101CMYC_18555785_Chip-Seq_ESCs_Mouse1.11223256
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10392405
103* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09820656
104KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08520900
105STAT3_23295773_ChIP-Seq_U87_Human1.07649475
106SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06986134
107P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06563570
108FLI1_21867929_ChIP-Seq_TH2_Mouse1.05791353
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.05709589
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05530845
111KDM2B_26808549_Chip-Seq_REH_Human1.05356544
112GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05190605
113SOX9_26525672_Chip-Seq_HEART_Mouse1.05031508
114TAL1_26923725_Chip-Seq_HPCs_Mouse1.04914995
115DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04837897
116AHR_22903824_ChIP-Seq_MCF-7_Human1.04468528
117MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03735563
118TP53_16413492_ChIP-PET_HCT116_Human1.02331930
119RING1B_27294783_Chip-Seq_NPCs_Mouse1.01037168
120YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01026576
121HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00912133
122* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00648561
123* TCF4_23295773_ChIP-Seq_U87_Human1.00321786
124WT1_19549856_ChIP-ChIP_CCG9911_Human0.97851136
125UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96846506
126RUNX2_22187159_ChIP-Seq_PCA_Human0.96478529
127PRDM14_20953172_ChIP-Seq_ESCs_Human0.96466701
128TP53_18474530_ChIP-ChIP_U2OS_Human0.96411743
129BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96292200
130GATA1_22025678_ChIP-Seq_K562_Human0.94836631
131POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93045447
132TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93045447
133TCF4_22108803_ChIP-Seq_LS180_Human0.92999858
134RNF2_27304074_Chip-Seq_NSC_Mouse0.91088058
135SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90392488

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.47375467
2MP0003880_abnormal_central_pattern4.09269967
3MP0003635_abnormal_synaptic_transmissio3.73403558
4MP0005646_abnormal_pituitary_gland3.37683905
5MP0003122_maternal_imprinting3.14446804
6MP0009745_abnormal_behavioral_response3.11120086
7MP0002063_abnormal_learning/memory/cond2.83728877
8MP0002064_seizures2.82362415
9MP0004270_analgesia2.66560298
10MP0002822_catalepsy2.47369959
11MP0002572_abnormal_emotion/affect_behav2.37156398
12MP0001968_abnormal_touch/_nociception2.30989372
13MP0001501_abnormal_sleep_pattern2.23062786
14MP0000566_synostosis2.21268990
15MP0009046_muscle_twitch2.10378368
16MP0002272_abnormal_nervous_system2.09080464
17MP0005187_abnormal_penis_morphology2.03658161
18MP0008877_abnormal_DNA_methylation2.01870780
19MP0001486_abnormal_startle_reflex1.95300825
20MP0003890_abnormal_embryonic-extraembry1.82215243
21MP0003011_delayed_dark_adaptation1.80556910
22MP0001529_abnormal_vocalization1.78858454
23MP0002736_abnormal_nociception_after1.75501781
24MP0002909_abnormal_adrenal_gland1.70111689
25MP0004924_abnormal_behavior1.70090181
26MP0005386_behavior/neurological_phenoty1.70090181
27MP0008569_lethality_at_weaning1.69090370
28MP0002102_abnormal_ear_morphology1.66581259
29MP0003283_abnormal_digestive_organ1.65151931
30MP0002067_abnormal_sensory_capabilities1.62440680
31MP0006292_abnormal_olfactory_placode1.61932238
32MP0009780_abnormal_chondrocyte_physiolo1.59921057
33MP0006276_abnormal_autonomic_nervous1.57648906
34MP0002734_abnormal_mechanical_nocicepti1.53702421
35MP0001984_abnormal_olfaction1.50277103
36MP0004811_abnormal_neuron_physiology1.46835401
37MP0002837_dystrophic_cardiac_calcinosis1.46279542
38MP0003787_abnormal_imprinting1.45373244
39MP0008961_abnormal_basal_metabolism1.44818684
40MP0003633_abnormal_nervous_system1.43476602
41MP0010368_abnormal_lymphatic_system1.41836045
42MP0002557_abnormal_social/conspecific_i1.40926471
43MP0002184_abnormal_innervation1.39805855
44MP0005423_abnormal_somatic_nervous1.39251285
45MP0000569_abnormal_digit_pigmentation1.39126425
46MP0004742_abnormal_vestibular_system1.37691660
47MP0001440_abnormal_grooming_behavior1.33682269
48MP0003121_genomic_imprinting1.33470276
49MP0002638_abnormal_pupillary_reflex1.32496550
50MP0002234_abnormal_pharynx_morphology1.32311615
51MP0005171_absent_coat_pigmentation1.31177770
52MP0002751_abnormal_autonomic_nervous1.29322014
53MP0004484_altered_response_of1.29134326
54MP0000778_abnormal_nervous_system1.28019818
55MP0005394_taste/olfaction_phenotype1.27997150
56MP0005499_abnormal_olfactory_system1.27997150
57MP0000013_abnormal_adipose_tissue1.24322054
58MP0003329_amyloid_beta_deposits1.23616638
59MP0004133_heterotaxia1.23567121
60MP0002733_abnormal_thermal_nociception1.23391854
61MP0003119_abnormal_digestive_system1.22785774
62MP0005551_abnormal_eye_electrophysiolog1.22119746
63MP0004885_abnormal_endolymph1.20142969
64MP0000631_abnormal_neuroendocrine_gland1.19611577
65MP0006072_abnormal_retinal_apoptosis1.18472095
66MP0002735_abnormal_chemical_nociception1.18181406
67MP0003567_abnormal_fetal_cardiomyocyte1.17954074
68MP0000516_abnormal_urinary_system1.15814842
69MP0005367_renal/urinary_system_phenotyp1.15814842
70MP0002127_abnormal_cardiovascular_syste1.15244343
71MP0001986_abnormal_taste_sensitivity1.14969689
72MP0000372_irregular_coat_pigmentation1.14028177
73MP0003631_nervous_system_phenotype1.13814027
74MP0008789_abnormal_olfactory_epithelium1.13358361
75MP0001188_hyperpigmentation1.11902681
76MP0002938_white_spotting1.09983677
77MP0003937_abnormal_limbs/digits/tail_de1.09753056
78MP0001299_abnormal_eye_distance/1.09227639
79MP0001485_abnormal_pinna_reflex1.08835757
80MP0002066_abnormal_motor_capabilities/c1.07721785
81MP0002882_abnormal_neuron_morphology1.07523070
82MP0001970_abnormal_pain_threshold1.07503132
83MP0005167_abnormal_blood-brain_barrier1.07126790
84MP0000955_abnormal_spinal_cord1.05686625
85MP0005248_abnormal_Harderian_gland1.05175551
86MP0002233_abnormal_nose_morphology1.04434483
87MP0001879_abnormal_lymphatic_vessel1.04178506
88MP0002752_abnormal_somatic_nervous1.03211853
89MP0003861_abnormal_nervous_system1.03202477
90MP0000537_abnormal_urethra_morphology1.02822076
91MP0005645_abnormal_hypothalamus_physiol1.01139162
92MP0004215_abnormal_myocardial_fiber0.99173421
93MP0003938_abnormal_ear_development0.97945366
94MP0010234_abnormal_vibrissa_follicle0.96635422
95MP0005535_abnormal_body_temperature0.94816068
96MP0004142_abnormal_muscle_tone0.94138314
97MP0001502_abnormal_circadian_rhythm0.93018072
98MP0004085_abnormal_heartbeat0.91583795
99MP0003123_paternal_imprinting0.90509355
100MP0003943_abnormal_hepatobiliary_system0.89591734
101MP0000026_abnormal_inner_ear0.89216196
102MP0000751_myopathy0.88132319
103MP0004147_increased_porphyrin_level0.87852990
104MP0002876_abnormal_thyroid_physiology0.87851783
105MP0000049_abnormal_middle_ear0.87163420
106MP0002152_abnormal_brain_morphology0.86735368
107MP0004130_abnormal_muscle_cell0.86604518
108MP0003879_abnormal_hair_cell0.86302817
109MP0008874_decreased_physiological_sensi0.85560515
110MP0001905_abnormal_dopamine_level0.84293079
111MP0001664_abnormal_digestion0.83455518
112MP0002229_neurodegeneration0.82077937
113MP0000639_abnormal_adrenal_gland0.81769262
114MP0005253_abnormal_eye_physiology0.81742987
115MP0001293_anophthalmia0.80899576
116MP0010329_abnormal_lipoprotein_level0.78641292
117MP0003385_abnormal_body_wall0.77058755
118MP0005195_abnormal_posterior_eye0.76958830
119MP0005391_vision/eye_phenotype0.75564114
120MP0002139_abnormal_hepatobiliary_system0.75553812
121MP0003632_abnormal_nervous_system0.75535781
122MP0008875_abnormal_xenobiotic_pharmacok0.75246736
123MP0005058_abnormal_lysosome_morphology0.73711834
124MP0000647_abnormal_sebaceous_gland0.72692111
125MP0001286_abnormal_eye_development0.71996367
126MP0005220_abnormal_exocrine_pancreas0.71745049
127MP0003690_abnormal_glial_cell0.71729004
128MP0001944_abnormal_pancreas_morphology0.71348059
129MP0005085_abnormal_gallbladder_physiolo0.71153586
130MP0002069_abnormal_eating/drinking_beha0.70840051
131MP0002081_perinatal_lethality0.70700765
132MP0001963_abnormal_hearing_physiology0.69703272
133MP0001270_distended_abdomen0.69495104
134MP0001177_atelectasis0.69059557
135MP0003075_altered_response_to0.66937375
136MP0005174_abnormal_tail_pigmentation0.66532834
137MP0004145_abnormal_muscle_electrophysio0.66142472
138MP0003950_abnormal_plasma_membrane0.65076178
139MP0002090_abnormal_vision0.64063031
140MP0005409_darkened_coat_color0.62965676
141MP0003137_abnormal_impulse_conducting0.62646323

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.87508118
2Visual hallucinations (HP:0002367)5.20658247
3Focal seizures (HP:0007359)4.40562590
4Atonic seizures (HP:0010819)3.83062118
5Myokymia (HP:0002411)3.72379147
6Hyperventilation (HP:0002883)3.71958296
7Febrile seizures (HP:0002373)3.49805104
8Absence seizures (HP:0002121)3.34736187
9Papilledema (HP:0001085)3.30786455
10Epileptic encephalopathy (HP:0200134)3.25225335
11Fatigue (HP:0012378)3.21045606
12Hepatoblastoma (HP:0002884)3.19547782
13Broad-based gait (HP:0002136)3.18308076
14Gait imbalance (HP:0002141)3.09371309
15Blue irides (HP:0000635)3.07981418
16Action tremor (HP:0002345)3.04254305
17Dialeptic seizures (HP:0011146)3.02580540
18Annular pancreas (HP:0001734)3.02374615
19Medial flaring of the eyebrow (HP:0010747)2.95292756
20Truncal ataxia (HP:0002078)2.90071278
21Progressive inability to walk (HP:0002505)2.86093279
22Generalized tonic-clonic seizures (HP:0002069)2.84001820
23Menstrual irregularities (HP:0000858)2.83867594
24Congenital primary aphakia (HP:0007707)2.77525971
25Depression (HP:0000716)2.77264787
26Agitation (HP:0000713)2.73647448
27Anxiety (HP:0000739)2.71036473
28Progressive cerebellar ataxia (HP:0002073)2.61080190
29Intestinal atresia (HP:0011100)2.58465032
30Vaginal atresia (HP:0000148)2.56623129
31Genital tract atresia (HP:0001827)2.55308583
32Termporal pattern (HP:0011008)2.55045221
33Insidious onset (HP:0003587)2.55045221
34Protruding tongue (HP:0010808)2.54705157
35Fair hair (HP:0002286)2.53495989
36Inability to walk (HP:0002540)2.49790758
37Epileptiform EEG discharges (HP:0011182)2.46602082
38Postural instability (HP:0002172)2.42684114
39Hypsarrhythmia (HP:0002521)2.42641152
40EEG with generalized epileptiform discharges (HP:0011198)2.41678814
41Nephrogenic diabetes insipidus (HP:0009806)2.41664489
42Generalized hypopigmentation of hair (HP:0011358)2.39797385
43Abnormality of the corticospinal tract (HP:0002492)2.38803488
44Stereotypic behavior (HP:0000733)2.37493791
45Impaired smooth pursuit (HP:0007772)2.36900623
46Conjugated hyperbilirubinemia (HP:0002908)2.35174592
47Scanning speech (HP:0002168)2.33341971
48Gaze-evoked nystagmus (HP:0000640)2.33304288
49Dysmetric saccades (HP:0000641)2.31766328
50Volvulus (HP:0002580)2.30643500
51Amblyopia (HP:0000646)2.26619732
52Hypothermia (HP:0002045)2.24844536
53Exotropia (HP:0000577)2.24316906
54Specific learning disability (HP:0001328)2.24024663
55Drooling (HP:0002307)2.23756782
56Excessive salivation (HP:0003781)2.23756782
57Impaired vibration sensation in the lower limbs (HP:0002166)2.22750897
58Abnormality of the labia minora (HP:0012880)2.22709300
59Broad metatarsal (HP:0001783)2.19429484
60Tented upper lip vermilion (HP:0010804)2.17683990
61Hemiparesis (HP:0001269)2.17292993
62Poor eye contact (HP:0000817)2.16363753
63Poor coordination (HP:0002370)2.16127399
64Nephronophthisis (HP:0000090)2.15999611
65Abnormal pancreas size (HP:0012094)2.15546968
66Dysdiadochokinesis (HP:0002075)2.12318603
67Degeneration of the lateral corticospinal tracts (HP:0002314)2.11446007
68Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.11446007
69Diplopia (HP:0000651)2.11392932
70Abnormality of binocular vision (HP:0011514)2.11392932
71Torticollis (HP:0000473)2.11012065
72Limb dystonia (HP:0002451)2.10374497
73J-shaped sella turcica (HP:0002680)2.07582470
74Fetal akinesia sequence (HP:0001989)2.05961842
75Heterochromia iridis (HP:0001100)2.05681695
76Goiter (HP:0000853)2.05344311
77Papillary thyroid carcinoma (HP:0002895)2.04240032
78Focal dystonia (HP:0004373)2.04196106
79Type II lissencephaly (HP:0007260)2.03680473
80Impaired social interactions (HP:0000735)2.02216296
81Abnormal social behavior (HP:0012433)2.02216296
82Mutism (HP:0002300)2.02035152
83Failure to thrive in infancy (HP:0001531)2.01861482
84Neuroendocrine neoplasm (HP:0100634)2.00787428
85Aqueductal stenosis (HP:0002410)1.99186434
86Obsessive-compulsive behavior (HP:0000722)1.98809363
87Deep venous thrombosis (HP:0002625)1.98464711
88Abnormality of the lower motor neuron (HP:0002366)1.97006036
89Postural tremor (HP:0002174)1.95438532
90Ankyloglossia (HP:0010296)1.95401556
91True hermaphroditism (HP:0010459)1.94036636
92Hemiplegia (HP:0002301)1.93543132
93Postaxial hand polydactyly (HP:0001162)1.92920333
94Pheochromocytoma (HP:0002666)1.92263800
95Oligodactyly (hands) (HP:0001180)1.91896918
96Craniofacial dystonia (HP:0012179)1.91746764
97Hypoventilation (HP:0002791)1.91276190
98Macroorchidism (HP:0000053)1.91008909
99Megalencephaly (HP:0001355)1.90963074
100Abnormality of ocular smooth pursuit (HP:0000617)1.90216744
101Status epilepticus (HP:0002133)1.89825760
102Optic nerve hypoplasia (HP:0000609)1.88820326
103Neoplasm of the oral cavity (HP:0100649)1.88800914
104Central scotoma (HP:0000603)1.87559986
105Delayed CNS myelination (HP:0002188)1.87409673
106Broad foot (HP:0001769)1.87061778
107White forelock (HP:0002211)1.87052789
108Spontaneous abortion (HP:0005268)1.85971088
109Abnormality of the renal medulla (HP:0100957)1.85518889
110Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.85316525
111Abnormal eating behavior (HP:0100738)1.85163573
112Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.82271916
113Shawl scrotum (HP:0000049)1.81983736
114Abnormality of the metopic suture (HP:0005556)1.81787086
115Urinary bladder sphincter dysfunction (HP:0002839)1.81606426
116Chronic hepatic failure (HP:0100626)1.80402981
117Growth hormone deficiency (HP:0000824)1.80075887
118Septo-optic dysplasia (HP:0100842)1.78881413
119Narrow nasal bridge (HP:0000446)1.78844310
120Poor suck (HP:0002033)1.78429966
121Psychosis (HP:0000709)1.78401849
122Polyphagia (HP:0002591)1.78121086
123Supranuclear gaze palsy (HP:0000605)1.77668812
124Cone-rod dystrophy (HP:0000548)1.76635446
125Cerebral inclusion bodies (HP:0100314)1.74680782
126Intention tremor (HP:0002080)1.74648734
127Intellectual disability, severe (HP:0010864)1.73855932
128Decreased testicular size (HP:0008734)1.73383572
129Bradykinesia (HP:0002067)1.73357806
130Morphological abnormality of the middle ear (HP:0008609)1.72565329
131Dysmetria (HP:0001310)1.72152155
132Anophthalmia (HP:0000528)1.72017959
133Buphthalmos (HP:0000557)1.71833474
134Thyroid carcinoma (HP:0002890)1.71598590
135Abnormality of the pubic bones (HP:0003172)1.70737041
136Vascular tortuosity (HP:0004948)1.69477472
137Arthropathy (HP:0003040)1.67948781
138Neoplasm of the tracheobronchial system (HP:0100552)1.67266588
139Ankle clonus (HP:0011448)1.66692450
140Ketoacidosis (HP:0001993)1.66501148
141Narrow forehead (HP:0000341)1.65960917
142Short foot (HP:0001773)1.65730123
143Cutaneous finger syndactyly (HP:0010554)1.64367064
144Renal hypoplasia (HP:0000089)1.64189673
145Pancreatic fibrosis (HP:0100732)1.64049015
146Widely spaced teeth (HP:0000687)1.64006992
147Sex reversal (HP:0012245)1.63263039
148Abnormal sex determination (HP:0012244)1.63263039
149Aplasia/Hypoplasia of the sternum (HP:0006714)1.62645045
150Hypoglycemic seizures (HP:0002173)1.62550912
151Urinary urgency (HP:0000012)1.62275598
152Arterial tortuosity (HP:0005116)1.61967627
153Ventricular fibrillation (HP:0001663)1.61722332
154Hyperinsulinemic hypoglycemia (HP:0000825)1.61552323
155Gastroesophageal reflux (HP:0002020)1.61459877
156Absent speech (HP:0001344)1.61355892
157Cystic hygroma (HP:0000476)1.61004760
158Generalized myoclonic seizures (HP:0002123)1.60713648
159Amyotrophic lateral sclerosis (HP:0007354)1.58937385
160Spastic tetraplegia (HP:0002510)1.58858449
161Lissencephaly (HP:0001339)1.57772158
162Aplasia/Hypoplasia of the lens (HP:0008063)1.57198557
163Scrotal hypoplasia (HP:0000046)1.56436048
164Micropenis (HP:0000054)1.56199592
165Abnormality of midbrain morphology (HP:0002418)1.55487134

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.27433898
2NTRK33.60174579
3EPHA43.47337051
4RIPK12.89623242
5MAP3K42.83124081
6DAPK22.80848186
7MAP4K22.65304100
8MAP2K72.64478665
9FRK2.31015552
10MINK12.13920724
11MAP2K41.98704883
12BCR1.90220563
13BRD41.88096523
14MAP3K121.81785631
15FES1.73751986
16MKNK21.72605585
17MARK11.70808256
18DAPK11.66781266
19RIPK41.61567208
20NTRK21.61418107
21MAP3K91.60382912
22KSR21.56813129
23CAMKK11.55726619
24TRIM281.55403244
25LATS11.54357024
26EPHA31.53714841
27RET1.53222543
28TIE11.52857293
29CASK1.48342909
30TNIK1.43814355
31CDK191.40689404
32KSR11.35605544
33DYRK21.27293913
34MKNK11.26707775
35MUSK1.24907503
36GRK61.23451114
37PNCK1.20491982
38CSNK1G21.20448131
39SIK21.20024168
40CAMKK21.18948006
41WEE11.15835734
42MAPK131.15821118
43CDK51.12710769
44TAF11.10086965
45SGK21.07930240
46AKT31.07751552
47BMPR1B1.06824286
48UHMK11.04135729
49GRK51.01838971
50MAP3K21.00282203
51CSNK1G30.98728185
52DYRK30.98503722
53NTRK10.95062939
54OBSCN0.95005091
55WNK30.90656806
56STK390.89246913
57CSNK1G10.87743885
58PTK2B0.85424297
59SCYL20.85155074
60PAK60.84110328
61SGK2230.83530416
62SGK4940.83530416
63PKN20.82723663
64FGR0.82422279
65PRKCH0.81883629
66SGK30.81455298
67DYRK1A0.80906332
68FGFR20.80621751
69CAMK2A0.79452147
70MAP3K60.79044936
71PLK20.78898190
72PRKCG0.77291845
73CAMK10.77228531
74PTK60.76257631
75MAP4K10.74183868
76TYRO30.73505529
77PINK10.71726840
78NUAK10.71580540
79SGK10.71411923
80DYRK1B0.70900649
81PRKD30.70464719
82CCNB10.69806658
83OXSR10.69411441
84PAK30.67673847
85CAMK2B0.67647439
86ACVR1B0.67465793
87PHKG20.66518237
88PHKG10.66518237
89ERBB40.64687012
90CSNK1A1L0.64322313
91EPHB20.63786849
92ERBB30.62991928
93YES10.62504152
94FYN0.61947212
95STK110.61849272
96MAP3K10.61581158
97MAPK150.59766967
98PASK0.59642330
99INSRR0.59206151
100NLK0.59065055
101PDK10.58784297
102PRKCQ0.57297336
103TGFBR20.57285089
104CAMK1G0.56615708
105STK38L0.55377883
106BRSK20.54856310
107EGFR0.54634703
108MAP3K100.54532723
109STK30.53617839
110CDK30.53166270
111EIF2AK30.52067900
112PRKCE0.50894650
113RAF10.50677201
114CLK10.49934414
115PRKG10.49054496
116HIPK20.48369359
117PKN10.47310002
118PRKAA20.45853438
119MATK0.45632900
120MAP3K50.45351094
121RPS6KA40.45343351
122ERBB20.44581456
123RPS6KB10.44357767
124KIT0.44054165
125CSNK1D0.43309427
126CSNK1E0.43234770
127STK380.43020357
128FGFR30.42910296
129PIK3CA0.42658282
130SRPK10.42524273
131RPS6KA30.42447045
132MAP3K70.42422663
133IGF1R0.42326651
134ADRBK10.41985996
135GRK10.41813471
136CAMK2D0.40422247
137CAMK40.39825056
138TAOK30.39514457
139PLK30.38439659
140FGFR10.38086729
141PRKCZ0.37133984
142GRK70.36755417
143CDK140.36112467
144WNK40.35995100
145SRC0.35228983
146PRKD10.34216036
147PRKACA0.33946235
148TGFBR10.33050984

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.22779896
2Olfactory transduction_Homo sapiens_hsa047402.72681243
3GABAergic synapse_Homo sapiens_hsa047272.58192311
4Circadian entrainment_Homo sapiens_hsa047132.56597153
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.44756434
6Glutamatergic synapse_Homo sapiens_hsa047242.30816954
7Morphine addiction_Homo sapiens_hsa050322.30447862
8Long-term potentiation_Homo sapiens_hsa047202.26511059
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26403029
10Synaptic vesicle cycle_Homo sapiens_hsa047212.24442574
11Amphetamine addiction_Homo sapiens_hsa050312.21487862
12Dopaminergic synapse_Homo sapiens_hsa047282.11584099
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.10440784
14Nitrogen metabolism_Homo sapiens_hsa009102.00223178
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.91345000
16Salivary secretion_Homo sapiens_hsa049701.88849313
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79319873
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.79171443
19Insulin secretion_Homo sapiens_hsa049111.77223665
20Renin secretion_Homo sapiens_hsa049241.75491766
21Long-term depression_Homo sapiens_hsa047301.72347233
22Gastric acid secretion_Homo sapiens_hsa049711.70629606
23Circadian rhythm_Homo sapiens_hsa047101.69732489
24Cholinergic synapse_Homo sapiens_hsa047251.69534232
25Cocaine addiction_Homo sapiens_hsa050301.62778152
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56825374
27Taste transduction_Homo sapiens_hsa047421.42302362
28Hedgehog signaling pathway_Homo sapiens_hsa043401.39859092
29Calcium signaling pathway_Homo sapiens_hsa040201.36698359
30Serotonergic synapse_Homo sapiens_hsa047261.35831201
31Oxytocin signaling pathway_Homo sapiens_hsa049211.35613479
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.34719540
33Protein export_Homo sapiens_hsa030601.33941604
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33456472
35GnRH signaling pathway_Homo sapiens_hsa049121.19100032
36Bile secretion_Homo sapiens_hsa049761.17212520
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15619507
38cAMP signaling pathway_Homo sapiens_hsa040241.15223254
39Estrogen signaling pathway_Homo sapiens_hsa049151.10328789
40Gap junction_Homo sapiens_hsa045401.10296423
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08152300
42Melanogenesis_Homo sapiens_hsa049161.07620491
43Basal cell carcinoma_Homo sapiens_hsa052171.04948733
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.03266717
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02606873
46Thyroid hormone synthesis_Homo sapiens_hsa049180.99089406
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97429533
48Wnt signaling pathway_Homo sapiens_hsa043100.95503833
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94451024
50Glucagon signaling pathway_Homo sapiens_hsa049220.93231172
51Hippo signaling pathway_Homo sapiens_hsa043900.92750315
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91677156
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.90920998
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90418567
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89828410
56Glioma_Homo sapiens_hsa052140.89669035
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88474765
58Phototransduction_Homo sapiens_hsa047440.86511907
59Regulation of autophagy_Homo sapiens_hsa041400.86407824
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.86396294
61Steroid biosynthesis_Homo sapiens_hsa001000.86087287
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85882578
63Ether lipid metabolism_Homo sapiens_hsa005650.83790069
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83746986
65Type II diabetes mellitus_Homo sapiens_hsa049300.81452697
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.76804285
67Dorso-ventral axis formation_Homo sapiens_hsa043200.76727927
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74645858
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74491642
70Non-small cell lung cancer_Homo sapiens_hsa052230.74019321
71Basal transcription factors_Homo sapiens_hsa030220.72788311
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72552457
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70423956
74Pancreatic secretion_Homo sapiens_hsa049720.69383718
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69007112
76Tight junction_Homo sapiens_hsa045300.68890886
77Dilated cardiomyopathy_Homo sapiens_hsa054140.67797063
78Oocyte meiosis_Homo sapiens_hsa041140.66630231
79Platelet activation_Homo sapiens_hsa046110.66349848
80Cardiac muscle contraction_Homo sapiens_hsa042600.65508672
81Arginine biosynthesis_Homo sapiens_hsa002200.65141782
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.65058010
83Axon guidance_Homo sapiens_hsa043600.64994017
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64178029
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62877733
86Fatty acid elongation_Homo sapiens_hsa000620.61845195
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61541736
88Butanoate metabolism_Homo sapiens_hsa006500.59776834
89Starch and sucrose metabolism_Homo sapiens_hsa005000.59031767
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.57486613
91Peroxisome_Homo sapiens_hsa041460.56566709
92Rap1 signaling pathway_Homo sapiens_hsa040150.55806016
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54743741
94Fatty acid metabolism_Homo sapiens_hsa012120.54289044
95Colorectal cancer_Homo sapiens_hsa052100.53527405
96Alcoholism_Homo sapiens_hsa050340.53301696
97RNA degradation_Homo sapiens_hsa030180.53244940
98Collecting duct acid secretion_Homo sapiens_hsa049660.52955414
99AMPK signaling pathway_Homo sapiens_hsa041520.48847915
100TGF-beta signaling pathway_Homo sapiens_hsa043500.47157766
101MAPK signaling pathway_Homo sapiens_hsa040100.46721512
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45738826
103beta-Alanine metabolism_Homo sapiens_hsa004100.45217866
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.44798001
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44589426
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44269681
107Vibrio cholerae infection_Homo sapiens_hsa051100.43915253
108Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40817345
109Complement and coagulation cascades_Homo sapiens_hsa046100.40271890
110ErbB signaling pathway_Homo sapiens_hsa040120.40256882
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39881666
112Endometrial cancer_Homo sapiens_hsa052130.38670944
113Tryptophan metabolism_Homo sapiens_hsa003800.38542498
114Fatty acid biosynthesis_Homo sapiens_hsa000610.38220817
115Choline metabolism in cancer_Homo sapiens_hsa052310.37759803
116Insulin signaling pathway_Homo sapiens_hsa049100.37517104
117mTOR signaling pathway_Homo sapiens_hsa041500.36853586
118Ovarian steroidogenesis_Homo sapiens_hsa049130.35981816
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35904144
120Propanoate metabolism_Homo sapiens_hsa006400.35678165
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35540879
122ABC transporters_Homo sapiens_hsa020100.35140630
123Inositol phosphate metabolism_Homo sapiens_hsa005620.34572448
124Ras signaling pathway_Homo sapiens_hsa040140.34249634
125Prion diseases_Homo sapiens_hsa050200.33020587
126Fatty acid degradation_Homo sapiens_hsa000710.32633773
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28440235
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28369910
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28316327

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