CASC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.57454019
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.33425181
3motile cilium assembly (GO:0044458)8.28225125
4axoneme assembly (GO:0035082)6.82295986
5multicellular organism reproduction (GO:0032504)6.56331366
6ventricular system development (GO:0021591)6.54431867
7fusion of sperm to egg plasma membrane (GO:0007342)6.48118062
8sperm motility (GO:0030317)6.35566821
9piRNA metabolic process (GO:0034587)6.16151155
10acrosome assembly (GO:0001675)5.59396249
11acrosome reaction (GO:0007340)5.43826535
12sperm-egg recognition (GO:0035036)5.16441085
13GTP biosynthetic process (GO:0006183)5.12524284
14male meiosis (GO:0007140)5.05194738
15reproduction (GO:0000003)4.94767442
16retinal cone cell development (GO:0046549)4.91126882
17left/right axis specification (GO:0070986)4.89453955
18cell wall macromolecule catabolic process (GO:0016998)4.87153429
19cell wall macromolecule metabolic process (GO:0044036)4.87153429
20plasma membrane fusion (GO:0045026)4.84332358
21nucleoside diphosphate phosphorylation (GO:0006165)4.84276739
22single fertilization (GO:0007338)4.77374938
23intraciliary transport (GO:0042073)4.75465803
24spermatid development (GO:0007286)4.67122755
25binding of sperm to zona pellucida (GO:0007339)4.60244021
26cell-cell recognition (GO:0009988)4.53902124
27regulation of cilium movement (GO:0003352)4.50409957
28cilium organization (GO:0044782)4.42698854
29regulation of microtubule-based movement (GO:0060632)4.41045103
30vitamin transmembrane transport (GO:0035461)4.40229538
31male meiosis I (GO:0007141)4.36106830
32DNA methylation involved in gamete generation (GO:0043046)4.34369815
33UTP biosynthetic process (GO:0006228)4.24187769
34cilium assembly (GO:0042384)4.23777560
35cilium morphogenesis (GO:0060271)3.98503458
36fertilization (GO:0009566)3.93441076
37regulation of female gonad development (GO:2000194)3.90972030
38pyrimidine-containing compound transmembrane transport (GO:0072531)3.88506551
39meiotic cell cycle (GO:0051321)3.87584858
40microtubule depolymerization (GO:0007019)3.83762456
41otic vesicle formation (GO:0030916)3.76432336
42cellular component assembly involved in morphogenesis (GO:0010927)3.68248906
43left/right pattern formation (GO:0060972)3.66140688
44nonmotile primary cilium assembly (GO:0035058)3.54305900
45UTP metabolic process (GO:0046051)3.53472081
46centriole assembly (GO:0098534)3.53207195
47protein localization to cilium (GO:0061512)3.52263281
48smoothened signaling pathway (GO:0007224)3.51164649
49centriole replication (GO:0007099)3.49445788
50spermatogenesis (GO:0007283)3.48120564
51male gamete generation (GO:0048232)3.46510488
52microtubule severing (GO:0051013)3.45488731
53photoreceptor cell maintenance (GO:0045494)3.36988741
54limb bud formation (GO:0060174)3.35283182
55synaptonemal complex organization (GO:0070193)3.34941719
56diterpenoid biosynthetic process (GO:0016102)3.32641650
57regulation of DNA methylation (GO:0044030)3.31385527
58gamete generation (GO:0007276)3.31298085
59determination of bilateral symmetry (GO:0009855)3.27270591
60primary alcohol catabolic process (GO:0034310)3.25578970
61negative regulation of cytosolic calcium ion concentration (GO:0051481)3.22979688
62spermatid nucleus differentiation (GO:0007289)3.20549926
63specification of symmetry (GO:0009799)3.20240135
64retinoic acid metabolic process (GO:0042573)3.18168940
65keratinocyte development (GO:0003334)3.17361811
66negative regulation of inclusion body assembly (GO:0090084)3.16658751
67meiosis I (GO:0007127)3.15633583
68microtubule-based movement (GO:0007018)3.11649761
69negative regulation of cAMP-mediated signaling (GO:0043951)3.09526277
70phosphorelay signal transduction system (GO:0000160)3.08500908
71neuron fate determination (GO:0048664)3.07743815
72eye photoreceptor cell differentiation (GO:0001754)3.05314891
73photoreceptor cell differentiation (GO:0046530)3.05314891
74CTP biosynthetic process (GO:0006241)3.04839396
75CTP metabolic process (GO:0046036)3.04839396
76guanosine-containing compound biosynthetic process (GO:1901070)3.03821993
77sperm capacitation (GO:0048240)2.93825590
78cytoplasmic microtubule organization (GO:0031122)2.87060367
79negative regulation of T cell differentiation in thymus (GO:0033085)2.85593694
80cell projection assembly (GO:0030031)2.84957398
81retinal rod cell development (GO:0046548)2.83960275
82photoreceptor cell development (GO:0042461)2.83418356
83microtubule bundle formation (GO:0001578)2.81834547
84positive regulation of gastrulation (GO:2000543)2.79271278
85female gamete generation (GO:0007292)2.79188824
86organic cation transport (GO:0015695)2.74423329
87deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.73240745
88ethanol metabolic process (GO:0006067)2.72736353
89establishment of tissue polarity (GO:0007164)2.72360343
90establishment of planar polarity (GO:0001736)2.72360343
91germ cell development (GO:0007281)2.70533090
92microtubule-based process (GO:0007017)2.69808905
93lateral ventricle development (GO:0021670)2.69041727
94phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.68752636
95cellular process involved in reproduction in multicellular organism (GO:0022412)2.68289054
96lateral sprouting from an epithelium (GO:0060601)2.66907725
97organelle assembly (GO:0070925)2.65476936
98lung epithelium development (GO:0060428)2.65245065
99behavioral response to ethanol (GO:0048149)2.64995210
100meiotic nuclear division (GO:0007126)2.64061776
101limb development (GO:0060173)2.63393707
102appendage development (GO:0048736)2.63393707
103eye photoreceptor cell development (GO:0042462)2.62250722
104synaptonemal complex assembly (GO:0007130)2.61850496
105regulation of pigment cell differentiation (GO:0050932)2.60329547
106response to xenobiotic stimulus (GO:0009410)2.59801104
107cell recognition (GO:0008037)2.58999111
108positive regulation of meiosis (GO:0045836)2.57661311
109establishment of apical/basal cell polarity (GO:0035089)2.56441939
110nucleotide phosphorylation (GO:0046939)2.56349293
111negative regulation of execution phase of apoptosis (GO:1900118)2.55943846
112multicellular organismal reproductive process (GO:0048609)2.54785837
113positive regulation of meiotic cell cycle (GO:0051446)2.54438269
114pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.53904945
115regulation of male gonad development (GO:2000018)2.53837441
116negative regulation of B cell mediated immunity (GO:0002713)2.53040412
117negative regulation of immunoglobulin mediated immune response (GO:0002890)2.53040412
118calcium ion-dependent exocytosis (GO:0017156)2.47273921
119establishment or maintenance of monopolar cell polarity (GO:0061339)2.46836578
120establishment of monopolar cell polarity (GO:0061162)2.46836578
121positive regulation of protein kinase C signaling (GO:0090037)2.46561919
122glycine transport (GO:0015816)2.44510173
123sensory perception of smell (GO:0007608)2.44214431
124intra-S DNA damage checkpoint (GO:0031573)2.43199751
125microtubule polymerization or depolymerization (GO:0031109)2.43180655
126axon ensheathment in central nervous system (GO:0032291)2.42725249
127central nervous system myelination (GO:0022010)2.42725249
128sulfate transmembrane transport (GO:1902358)2.41813352
129chromosome organization involved in meiosis (GO:0070192)2.40482219
130regulation of meiosis I (GO:0060631)2.39386979
131glomerular epithelial cell development (GO:0072310)2.37968182
132pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.37865597
133retinal metabolic process (GO:0042574)2.36175180
134positive regulation of developmental pigmentation (GO:0048087)2.35201956
135positive regulation of hair cycle (GO:0042635)2.32719700
136positive regulation of hair follicle development (GO:0051798)2.32719700
137RNA destabilization (GO:0050779)2.30827048
138determination of left/right symmetry (GO:0007368)2.30285160
139regulation of acrosome reaction (GO:0060046)2.29771054
140protein polyglutamylation (GO:0018095)2.29284335
141terpenoid biosynthetic process (GO:0016114)2.28885102
142gene silencing by RNA (GO:0031047)2.27825257
143negative regulation of T cell mediated immunity (GO:0002710)2.27657556
144one-carbon compound transport (GO:0019755)2.26564861
145synapsis (GO:0007129)2.25627574
146positive regulation of male gonad development (GO:2000020)2.19356232
147axonemal dynein complex assembly (GO:0070286)11.3371342
148cilium or flagellum-dependent cell motility (GO:0001539)10.9913556
149cilium movement (GO:0003341)10.7114991

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.56431064
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.48356906
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.44190657
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.19424367
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.12952863
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.77742597
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.66797218
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.64899452
9GBX2_23144817_ChIP-Seq_PC3_Human2.63031617
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.62951523
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37952821
12SUZ12_27294783_Chip-Seq_NPCs_Mouse2.28149694
13VDR_22108803_ChIP-Seq_LS180_Human2.25900025
14NFE2_27457419_Chip-Seq_LIVER_Mouse2.13451726
15PCGF2_27294783_Chip-Seq_NPCs_Mouse2.13331345
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04788149
17TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse2.02075104
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.00649705
19DROSHA_22980978_ChIP-Seq_HELA_Human1.97987522
20TAF15_26573619_Chip-Seq_HEK293_Human1.96455319
21NANOG_18555785_Chip-Seq_ESCs_Mouse1.96342499
22ZNF274_21170338_ChIP-Seq_K562_Hela1.91283338
23EZH2_27294783_Chip-Seq_NPCs_Mouse1.89354037
24EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.87081608
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.83707340
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.81194776
27RNF2_27304074_Chip-Seq_NSC_Mouse1.80238066
28P53_22387025_ChIP-Seq_ESCs_Mouse1.78126994
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77975071
30SUZ12_18555785_Chip-Seq_ESCs_Mouse1.73443900
31TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72105933
32POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.72105933
33SMAD4_21799915_ChIP-Seq_A2780_Human1.69221369
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67787756
35E2F1_18555785_Chip-Seq_ESCs_Mouse1.67631780
36STAT3_18555785_Chip-Seq_ESCs_Mouse1.67167871
37EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.63697948
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62614691
39P300_19829295_ChIP-Seq_ESCs_Human1.62451591
40P300_18555785_Chip-Seq_ESCs_Mouse1.61470035
41CMYC_18555785_Chip-Seq_ESCs_Mouse1.60177941
42OCT4_18555785_Chip-Seq_ESCs_Mouse1.59920938
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58402724
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.56557410
45ER_23166858_ChIP-Seq_MCF-7_Human1.53132872
46FUS_26573619_Chip-Seq_HEK293_Human1.51730140
47SOX2_18555785_Chip-Seq_ESCs_Mouse1.51199742
48NMYC_18555785_Chip-Seq_ESCs_Mouse1.51110911
49CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.48331980
50TAL1_26923725_Chip-Seq_HPCs_Mouse1.48229528
51CRX_20693478_ChIP-Seq_RETINA_Mouse1.47750800
52KLF4_18555785_Chip-Seq_ESCs_Mouse1.46635553
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46517356
54ZFX_18555785_Chip-Seq_ESCs_Mouse1.45197618
55AHR_22903824_ChIP-Seq_MCF-7_Human1.44213492
56KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.42942422
57PU1_27457419_Chip-Seq_LIVER_Mouse1.42688614
58ARNT_22903824_ChIP-Seq_MCF-7_Human1.42597468
59FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42489536
60RUNX1_27457419_Chip-Seq_LIVER_Mouse1.42397236
61ESRRB_18555785_Chip-Seq_ESCs_Mouse1.41943356
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41361692
63AR_25329375_ChIP-Seq_VCAP_Human1.41255690
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.40469054
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.39638086
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39322967
67OCT4_21477851_ChIP-Seq_ESCs_Mouse1.38189015
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.37255994
69FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.35980597
70KDM2B_26808549_Chip-Seq_REH_Human1.35350693
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35106084
72RUNX2_22187159_ChIP-Seq_PCA_Human1.34739549
73GATA1_26923725_Chip-Seq_HPCs_Mouse1.33889486
74CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33863399
75CTCF_18555785_Chip-Seq_ESCs_Mouse1.33176136
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31735233
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31702486
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31429719
79TCF4_22108803_ChIP-Seq_LS180_Human1.30843104
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29944727
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28500166
82TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.28288723
83SOX2_19829295_ChIP-Seq_ESCs_Human1.26763082
84NANOG_19829295_ChIP-Seq_ESCs_Human1.26763082
85TCF4_23295773_ChIP-Seq_U87_Human1.26440028
86* SMAD4_21741376_ChIP-Seq_EPCs_Human1.25823270
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25808109
88SMAD1_18555785_Chip-Seq_ESCs_Mouse1.24647628
89STAT3_23295773_ChIP-Seq_U87_Human1.23612852
90* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23407203
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22419451
92EZH2_27304074_Chip-Seq_ESCs_Mouse1.22117286
93BCAT_22108803_ChIP-Seq_LS180_Human1.21835218
94TBL1_22424771_ChIP-Seq_293T_Human1.21151869
95REST_21632747_ChIP-Seq_MESCs_Mouse1.19360542
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18520614
97IRF1_19129219_ChIP-ChIP_H3396_Human1.18090608
98FOXA1_25329375_ChIP-Seq_VCAP_Human1.17314609
99FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17314609
100SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17249564
101FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16610673
102CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.16368680
103ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16183569
104SMRT_27268052_Chip-Seq_Bcells_Human1.15923413
105SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.14912597
106PIAS1_25552417_ChIP-Seq_VCAP_Human1.14014283
107JARID2_20064375_ChIP-Seq_MESCs_Mouse1.13444352
108EWS_26573619_Chip-Seq_HEK293_Human1.13389970
109ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12860594
110EZH2_27294783_Chip-Seq_ESCs_Mouse1.12786157
111NFYB_21822215_ChIP-Seq_K562_Human1.11779964
112TP53_18474530_ChIP-ChIP_U2OS_Human1.11760814
113CDX2_22108803_ChIP-Seq_LS180_Human1.09404009
114AR_20517297_ChIP-Seq_VCAP_Human1.08758873
115AR_21572438_ChIP-Seq_LNCaP_Human1.08700204
116RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08394587
117CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08104213
118FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07796252
119GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07632706
120TP53_16413492_ChIP-PET_HCT116_Human1.06809700
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06388471
122SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06090824
123ETV1_20927104_ChIP-Seq_GIST48_Human1.05555769
124SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.05484249
125PHF8_20622853_ChIP-Seq_HELA_Human1.05297387
126OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05277738
127TP53_22573176_ChIP-Seq_HFKS_Human1.05177629
128SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05090653
129GF1_26923725_Chip-Seq_HPCs_Mouse1.04849887
130NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04512321
131CBP_20019798_ChIP-Seq_JUKART_Human1.04100690
132IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04100690
133PRDM14_20953172_ChIP-Seq_ESCs_Human1.03524977
134LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03324625
135* SOX2_21211035_ChIP-Seq_LN229_Gbm1.03119517
136IGF1R_20145208_ChIP-Seq_DFB_Human1.01948803
137ERG_20517297_ChIP-Seq_VCAP_Human1.01891965
138GATA3_21878914_ChIP-Seq_MCF-7_Human0.99883433
139* TP63_23658742_ChIP-Seq_EP156T_Human0.97773610
140EP300_21415370_ChIP-Seq_HL-1_Mouse0.97189201
141CBP_21632823_ChIP-Seq_H3396_Human0.96338974
142FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.94709670
143MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94093975
144PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.92276748
145NANOG_20526341_ChIP-Seq_ESCs_Human0.91451122

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.47760025
2MP0003136_yellow_coat_color5.49884607
3MP0004381_abnormal_hair_follicle4.14133191
4MP0008789_abnormal_olfactory_epithelium3.89640507
5MP0008875_abnormal_xenobiotic_pharmacok3.13129199
6MP0005394_taste/olfaction_phenotype3.13071505
7MP0005499_abnormal_olfactory_system3.13071505
8MP0008877_abnormal_DNA_methylation3.06788472
9MP0006292_abnormal_olfactory_placode2.86935693
10MP0003698_abnormal_male_reproductive2.69677819
11MP0001929_abnormal_gametogenesis2.63716509
12MP0002102_abnormal_ear_morphology2.26827110
13MP0004043_abnormal_pH_regulation2.24614073
14MP0000579_abnormal_nail_morphology2.10113038
15MP0005646_abnormal_pituitary_gland2.08035620
16MP0002282_abnormal_trachea_morphology2.06568347
17MP0001188_hyperpigmentation2.01772759
18MP0004133_heterotaxia1.97829715
19MP0003787_abnormal_imprinting1.96009694
20MP0005623_abnormal_meninges_morphology1.95312506
21MP0002132_abnormal_respiratory_system1.94054759
22MP0002653_abnormal_ependyma_morphology1.91865051
23MP0003950_abnormal_plasma_membrane1.91465792
24MP0010030_abnormal_orbit_morphology1.84783667
25MP0002210_abnormal_sex_determination1.77266497
26MP0005075_abnormal_melanosome_morpholog1.76650384
27MP0005377_hearing/vestibular/ear_phenot1.75560262
28MP0003878_abnormal_ear_physiology1.75560262
29MP0001984_abnormal_olfaction1.74197669
30MP0005395_other_phenotype1.73206448
31MP0000383_abnormal_hair_follicle1.71335461
32MP0008004_abnormal_stomach_pH1.70905249
33MP0000566_synostosis1.68840758
34MP0004742_abnormal_vestibular_system1.67080924
35MP0009046_muscle_twitch1.62937697
36MP0003880_abnormal_central_pattern1.60722941
37MP0001293_anophthalmia1.59746104
38MP0009780_abnormal_chondrocyte_physiolo1.55109774
39MP0008995_early_reproductive_senescence1.50957976
40MP0003890_abnormal_embryonic-extraembry1.46805267
41MP0004019_abnormal_vitamin_homeostasis1.44403254
42MP0002161_abnormal_fertility/fecundity1.43952698
43MP0006072_abnormal_retinal_apoptosis1.41494398
44MP0003941_abnormal_skin_development1.40132574
45MP0005551_abnormal_eye_electrophysiolog1.34648040
46MP0003646_muscle_fatigue1.33280739
47MP0000427_abnormal_hair_cycle1.30448304
48MP0002249_abnormal_larynx_morphology1.27107238
49MP0002638_abnormal_pupillary_reflex1.26995632
50MP0000653_abnormal_sex_gland1.26459077
51MP0002009_preneoplasia1.24436788
52MP0001145_abnormal_male_reproductive1.18887961
53MP0002233_abnormal_nose_morphology1.18196825
54MP0005379_endocrine/exocrine_gland_phen1.17846236
55MP0000569_abnormal_digit_pigmentation1.16385195
56MP0002163_abnormal_gland_morphology1.16080063
57MP0003183_abnormal_peptide_metabolism1.15317023
58MP0005085_abnormal_gallbladder_physiolo1.15278006
59MP0005253_abnormal_eye_physiology1.14780225
60MP0002148_abnormal_hypersensitivity_rea1.13517236
61MP0002876_abnormal_thyroid_physiology1.13066063
62MP0003938_abnormal_ear_development1.11051414
63MP0000026_abnormal_inner_ear1.10954978
64MP0004142_abnormal_muscle_tone1.09352498
65MP0000631_abnormal_neuroendocrine_gland1.08383087
66MP0004134_abnormal_chest_morphology1.07282839
67MP0001324_abnormal_eye_pigmentation1.05908117
68MP0008057_abnormal_DNA_replication1.05683710
69MP0002098_abnormal_vibrissa_morphology1.05041430
70MP0002909_abnormal_adrenal_gland1.04175877
71MP0009250_abnormal_appendicular_skeleto1.03763814
72MP0003763_abnormal_thymus_physiology1.03640631
73MP0003011_delayed_dark_adaptation1.02539469
74MP0002938_white_spotting1.02195066
75MP0005423_abnormal_somatic_nervous1.02018832
76MP0003879_abnormal_hair_cell1.01514690
77MP0001986_abnormal_taste_sensitivity1.01502175
78MP0002734_abnormal_mechanical_nocicepti1.01088984
79MP0005195_abnormal_posterior_eye1.00583046
80MP0010386_abnormal_urinary_bladder1.00288146
81MP0002234_abnormal_pharynx_morphology0.99946473
82MP0005645_abnormal_hypothalamus_physiol0.97825336
83MP0001486_abnormal_startle_reflex0.97327951
84MP0002405_respiratory_system_inflammati0.95968086
85MP0001790_abnormal_immune_system0.95617766
86MP0005387_immune_system_phenotype0.95617766
87MP0002736_abnormal_nociception_after0.93988385
88MP0003937_abnormal_limbs/digits/tail_de0.93733016
89MP0005409_darkened_coat_color0.93524420
90MP0003724_increased_susceptibility_to0.93374291
91MP0003195_calcinosis0.93239778
92MP0002557_abnormal_social/conspecific_i0.91308498
93MP0001765_abnormal_ion_homeostasis0.90963194
94MP0001851_eye_inflammation0.90520162
95MP0000762_abnormal_tongue_morphology0.89821773
96MP0009697_abnormal_copulation0.88874563
97MP0005391_vision/eye_phenotype0.88627962
98MP0000049_abnormal_middle_ear0.88057251
99MP0010678_abnormal_skin_adnexa0.87540201
100MP0000015_abnormal_ear_pigmentation0.87045437
101MP0002095_abnormal_skin_pigmentation0.86028266
102MP0001963_abnormal_hearing_physiology0.84954350
103MP0001968_abnormal_touch/_nociception0.84738807
104MP0002229_neurodegeneration0.84401743
105MP0002160_abnormal_reproductive_system0.83837036
106MP0002139_abnormal_hepatobiliary_system0.83581089
107MP0001440_abnormal_grooming_behavior0.82937141
108MP0002572_abnormal_emotion/affect_behav0.82801269
109MP0002277_abnormal_respiratory_mucosa0.82766630
110MP0006276_abnormal_autonomic_nervous0.82134671
111MP0008058_abnormal_DNA_repair0.80267511
112MP0003699_abnormal_female_reproductive0.79429775
113MP0005647_abnormal_sex_gland0.78980650
114MP0001764_abnormal_homeostasis0.78810648
115MP0001661_extended_life_span0.78087816
116MP0000678_abnormal_parathyroid_gland0.77162088
117MP0000372_irregular_coat_pigmentation0.76400536
118MP0009745_abnormal_behavioral_response0.74324969
119MP0003252_abnormal_bile_duct0.72152193
120MP0001501_abnormal_sleep_pattern0.71760286
121MP0002067_abnormal_sensory_capabilities0.71210754
122MP0001664_abnormal_digestion0.71182667
123MP0005671_abnormal_response_to0.69316304
124MP0003718_maternal_effect0.68816483
125MP0005174_abnormal_tail_pigmentation0.68413637
126MP0005389_reproductive_system_phenotype0.67725297
127MP0003828_pulmonary_edema0.66168298
128MP0008260_abnormal_autophagy0.65978316
129MP0004215_abnormal_myocardial_fiber0.65777116
130MP0002752_abnormal_somatic_nervous0.65335057
131MP0001485_abnormal_pinna_reflex0.64738136
132MP0002272_abnormal_nervous_system0.64714186
133MP0002116_abnormal_craniofacial_bone0.64367257
134MP0002109_abnormal_limb_morphology0.63737252
135MP0001119_abnormal_female_reproductive0.63658078
136MP0002168_other_aberrant_phenotype0.63370389
137MP0001970_abnormal_pain_threshold0.62731519
138MP0000377_abnormal_hair_follicle0.61716825
139MP0000778_abnormal_nervous_system0.61608055
140MP0002735_abnormal_chemical_nociception0.60462171
141MP0003786_premature_aging0.60190524
142MP0004484_altered_response_of0.59855293
143MP0001905_abnormal_dopamine_level0.59527487
144MP0001502_abnormal_circadian_rhythm0.59178372
145MP0002928_abnormal_bile_duct0.58116918

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.86806663
2Abnormal ciliary motility (HP:0012262)9.41198902
3Absent/shortened dynein arms (HP:0200106)8.48164212
4Dynein arm defect of respiratory motile cilia (HP:0012255)8.48164212
5Rhinitis (HP:0012384)7.85784898
6Abnormal respiratory epithelium morphology (HP:0012253)7.73248483
7Abnormal respiratory motile cilium morphology (HP:0005938)7.73248483
8Chronic bronchitis (HP:0004469)5.69844798
9Bronchiectasis (HP:0002110)4.76489695
10Nasal polyposis (HP:0100582)3.89707820
11Nephronophthisis (HP:0000090)3.76475425
12Recurrent sinusitis (HP:0011108)3.52306745
13Infertility (HP:0000789)3.36608555
14True hermaphroditism (HP:0010459)3.27408835
15Bronchitis (HP:0012387)3.16216109
16Abnormality of the renal medulla (HP:0100957)3.05555455
17Abnormality of the nasal mucosa (HP:0000433)2.96904523
18Molar tooth sign on MRI (HP:0002419)2.93622823
19Abnormality of midbrain morphology (HP:0002418)2.93622823
20Fibular hypoplasia (HP:0003038)2.93427048
21Tubulointerstitial nephritis (HP:0001970)2.91718374
22Pancreatic fibrosis (HP:0100732)2.86972481
23Chronic sinusitis (HP:0011109)2.77883746
24Medial flaring of the eyebrow (HP:0010747)2.68360725
25Anencephaly (HP:0002323)2.62622191
26Recurrent otitis media (HP:0000403)2.62069616
27Chronic hepatic failure (HP:0100626)2.45666521
28Hyperactive renin-angiotensin system (HP:0000841)2.35620666
29Chromosomal breakage induced by crosslinking agents (HP:0003221)2.33049017
30Abnormal drinking behavior (HP:0030082)2.32643449
31Polydipsia (HP:0001959)2.32643449
32Sclerocornea (HP:0000647)2.32471437
33Pancreatic cysts (HP:0001737)2.29919720
34Chromsome breakage (HP:0040012)2.27037352
35Chronic otitis media (HP:0000389)2.19915643
36Congenital hepatic fibrosis (HP:0002612)2.15213926
37Tubular atrophy (HP:0000092)2.12857711
38Postaxial foot polydactyly (HP:0001830)2.10255265
39Lip pit (HP:0100267)2.09880594
40Decreased circulating renin level (HP:0003351)2.09465409
41Median cleft lip (HP:0000161)2.01315270
42Duplicated collecting system (HP:0000081)2.00827924
43Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.1527349
44Congenital primary aphakia (HP:0007707)1.99625645
45Aplasia/Hypoplasia of the fibula (HP:0006492)1.97403104
46Gait imbalance (HP:0002141)1.96113048
47Furrowed tongue (HP:0000221)1.95669620
48Stage 5 chronic kidney disease (HP:0003774)1.93461320
49Abnormality of the renal cortex (HP:0011035)1.89742740
50Abnormality of the nasal septum (HP:0000419)1.89136754
51Abnormality of the renal collecting system (HP:0004742)1.88924539
52Decreased central vision (HP:0007663)1.87427320
53Type II lissencephaly (HP:0007260)1.85076164
54Tubulointerstitial abnormality (HP:0001969)1.84510508
55Parakeratosis (HP:0001036)1.84126258
56Nephrogenic diabetes insipidus (HP:0009806)1.83401398
57Dry hair (HP:0011359)1.82380674
58Preaxial hand polydactyly (HP:0001177)1.80886397
59Occipital encephalocele (HP:0002085)1.79293626
60Sex reversal (HP:0012245)1.78730801
61Abnormal sex determination (HP:0012244)1.78730801
62Abnormality of permanent molar morphology (HP:0011071)1.77957779
63Abnormality of the dental root (HP:0006486)1.77957779
64Taurodontia (HP:0000679)1.77957779
65Oligodactyly (hands) (HP:0001180)1.76700044
66Aplasia/Hypoplasia of the spleen (HP:0010451)1.75907797
67Cystic liver disease (HP:0006706)1.75608196
68Abnormality of molar morphology (HP:0011070)1.75451944
69Abnormality of molar (HP:0011077)1.75451944
70Short femoral neck (HP:0100864)1.74493125
71Aplasia/Hypoplasia of the tongue (HP:0010295)1.73035271
72Abnormality of the dental pulp (HP:0006479)1.72669218
73Flat capital femoral epiphysis (HP:0003370)1.72437363
74Asplenia (HP:0001746)1.70261870
75Genital tract atresia (HP:0001827)1.70091644
76Epiphyseal dysplasia (HP:0002656)1.68211495
77Natal tooth (HP:0000695)1.65190458
78Bell-shaped thorax (HP:0001591)1.64343691
79Vaginal atresia (HP:0000148)1.63679822
80Abnormality of macular pigmentation (HP:0008002)1.63382517
81Irregular epiphyses (HP:0010582)1.63211873
82Aplasia/Hypoplasia of the lens (HP:0008063)1.63116541
83Male pseudohermaphroditism (HP:0000037)1.62723237
84Bifid tongue (HP:0010297)1.62174136
85Supernumerary spleens (HP:0009799)1.62038774
86Poor coordination (HP:0002370)1.60439229
87Azoospermia (HP:0000027)1.57570650
88Narrow forehead (HP:0000341)1.57009346
89Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.56869760
90Absent epiphyses (HP:0010577)1.56869760
91Abnormality of dentin (HP:0010299)1.56368795
92Abnormality of incisor morphology (HP:0011063)1.55973249
93Polyuria (HP:0000103)1.55175219
94Atelectasis (HP:0100750)1.55154807
95Postaxial hand polydactyly (HP:0001162)1.52993269
96Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.52376969
97Male infertility (HP:0003251)1.51210846
98Septo-optic dysplasia (HP:0100842)1.50547101
99Abnormal rod and cone electroretinograms (HP:0008323)1.49918823
100Stomatitis (HP:0010280)1.49718656
101Morphological abnormality of the middle ear (HP:0008609)1.48209852
102Abnormality of DNA repair (HP:0003254)1.47308694
103Neonatal short-limb short stature (HP:0008921)1.47280807
104Recurrent bronchitis (HP:0002837)1.47130316
105Aplasia/Hypoplasia of the tibia (HP:0005772)1.47022802
106Tubulointerstitial fibrosis (HP:0005576)1.47001002
107Retinitis pigmentosa (HP:0000510)1.46831878
108Abnormality of abdominal situs (HP:0011620)1.45951027
109Abdominal situs inversus (HP:0003363)1.45951027
110Hyperkalemia (HP:0002153)1.44336665
111Hyperaldosteronism (HP:0000859)1.44036621
112Absent rod-and cone-mediated responses on ERG (HP:0007688)1.42108364
113Aganglionic megacolon (HP:0002251)1.41936443
114Renal dysplasia (HP:0000110)1.41352331
115Abnormality of renin-angiotensin system (HP:0000847)1.40083200
116Hip dysplasia (HP:0001385)1.39538698
117Prominent nasal bridge (HP:0000426)1.39323548
118Abnormality of the epiphysis of the femoral head (HP:0010574)1.39275364
119Abnormality of femoral epiphyses (HP:0006499)1.38612501
120Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.38612501
121Oculomotor apraxia (HP:0000657)1.37748274
122Abnormality of renal excretion (HP:0011036)1.37541125
123Abnormality of the fibula (HP:0002991)1.37116087
12411 pairs of ribs (HP:0000878)1.37044602
125Hypoplasia of the capital femoral epiphysis (HP:0003090)1.35537760
126Nephropathy (HP:0000112)1.34988601
127Abnormal biliary tract physiology (HP:0012439)1.34228070
128Bile duct proliferation (HP:0001408)1.34228070
129Bony spicule pigmentary retinopathy (HP:0007737)1.34141432
130Cone-rod dystrophy (HP:0000548)1.32113099
131Abnormal urine output (HP:0012590)1.32085727
132Highly arched eyebrow (HP:0002553)1.30504308
133Multicystic kidney dysplasia (HP:0000003)1.27961487
134Short tibia (HP:0005736)1.22191392
135Anterior segment dysgenesis (HP:0007700)1.21331993
136Congenital sensorineural hearing impairment (HP:0008527)1.21015806
137Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.19854867
138Holoprosencephaly (HP:0001360)1.18120511
139Osteomalacia (HP:0002749)1.18007428
140Anophthalmia (HP:0000528)1.17701003
141Attenuation of retinal blood vessels (HP:0007843)1.15282040
142Dysdiadochokinesis (HP:0002075)1.15054241

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK33.49191274
2CASK3.37757102
3MAPK153.16518103
4PDK43.04481561
5PDK33.04481561
6PNCK2.62973696
7BRSK22.48592500
8MAP3K92.42521491
9PDK22.33786932
10ARAF2.12668338
11NUAK12.08786389
12TXK1.99787124
13WNK31.88784794
14TAOK31.81556844
15MUSK1.78040233
16TIE11.71169189
17GRK11.70346900
18MST41.69851080
19BMPR1B1.63524262
20NEK61.61447492
21GRK71.58075363
22WEE11.56357449
23STK38L1.55806354
24STK391.50756221
25MAP3K131.48766330
26PBK1.45451418
27MET1.44193070
28BLK1.42756470
29MAP3K41.42453573
30IRAK41.40570293
31IRAK11.36750691
32MAP3K141.35329525
33SIK31.32504241
34EPHA41.29425552
35INSRR1.28237674
36STK161.22964568
37MAP2K71.22442273
38EIF2AK21.21869734
39NTRK31.21720746
40NTRK21.21616073
41PRKCI1.20935446
42CLK11.19811851
43PTK2B1.19759298
44ACVR1B1.19366988
45EPHA21.17082926
46OXSR11.16896423
47MAPKAPK31.15899896
48TNIK1.14751587
49MAPK131.12299590
50FRK1.09275751
51VRK11.07594397
52AURKA1.07329435
53FGR1.06765034
54TESK11.04943567
55MAP4K21.04210466
56PRKCQ1.03413606
57PLK21.03253405
58WNK41.02675857
59BMPR21.01430693
60PKN10.99025104
61TRPM70.98062330
62STK30.96550023
63BCR0.95793273
64ERBB30.94796521
65LATS10.93254863
66IRAK20.92927468
67PLK40.92435970
68WNK10.90592394
69CDK80.90577813
70PRKCE0.89475009
71STK380.88292982
72TTK0.87947418
73STK100.87849528
74DYRK20.87698121
75PRKD30.86339625
76IRAK30.85602072
77ADRBK20.84471156
78DYRK30.81223947
79MAPKAPK50.80786194
80RIPK40.79558079
81NEK90.78133046
82PIK3CG0.76359394
83PLK10.74505416
84MKNK20.73445214
85ZAK0.72403193
86MAP3K60.71722466
87PRKD20.71263151
88STK240.70729448
89NLK0.70344171
90ADRBK10.70074704
91TRIM280.69982058
92YES10.68887828
93BRSK10.68355413
94PRKCG0.66689334
95MAPK70.65800017
96CDK190.65194793
97ERBB40.60929112
98CHEK20.60924299
99CAMKK20.59868227
100SGK20.58253057
101PRKG10.58241685
102ICK0.57643621
103CDK90.56598413
104IKBKE0.56581002
105MAP3K30.55620066
106RPS6KA50.55162385
107TGFBR10.54984769
108FGFR20.54812739
109CAMK2A0.53859452
110TEC0.53506850
111PIM10.48756337
112ERBB20.48319170
113PRKAA20.47680048
114MOS0.47086272
115NME10.45387291
116LYN0.43923049
117RAF10.43851200
118MARK20.42320709
119PRKCZ0.41542058
120BCKDK0.40794800
121DYRK1A0.40402438
122LCK0.39850970
123CDK50.39226310
124TLK10.38236261
125MAPK120.36205821
126CSNK1G20.35877666
127MAP3K50.35493793
128SGK2230.34899667
129SGK4940.34899667
130DMPK0.34332567
131PRKCA0.33595740
132MELK0.33314289
133PRKACA0.31757011
134PINK10.31316473
135TSSK60.29904156
136PRKACB0.29813748
137STK110.29322253
138ITK0.29027950
139BRAF0.28362404
140ROCK10.28228470
141BRD40.26508250
142CAMK10.25218925
143SGK10.24221616
144MAP3K70.22403597
145ATM0.22238286
146MAP2K20.22193172
147MAP2K40.21819662
148CSNK1D0.21615727
149PRKAA10.20221898
150CHUK0.20008420

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.22655247
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.01680308
3Chemical carcinogenesis_Homo sapiens_hsa052042.72596500
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.68358132
5Caffeine metabolism_Homo sapiens_hsa002322.57830270
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.56525450
7Histidine metabolism_Homo sapiens_hsa003402.56233562
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.32393717
9ABC transporters_Homo sapiens_hsa020102.20560617
10Ether lipid metabolism_Homo sapiens_hsa005652.19706320
11Fanconi anemia pathway_Homo sapiens_hsa034602.09882129
12Basal transcription factors_Homo sapiens_hsa030222.06787180
13Phenylalanine metabolism_Homo sapiens_hsa003601.97543711
14Nicotine addiction_Homo sapiens_hsa050331.94146932
15Primary immunodeficiency_Homo sapiens_hsa053401.89171226
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.78798960
17beta-Alanine metabolism_Homo sapiens_hsa004101.77986961
18Vitamin B6 metabolism_Homo sapiens_hsa007501.77061117
19Non-homologous end-joining_Homo sapiens_hsa034501.71511818
20Tyrosine metabolism_Homo sapiens_hsa003501.71256049
21Retinol metabolism_Homo sapiens_hsa008301.71072363
22Phototransduction_Homo sapiens_hsa047441.70785709
23Sphingolipid metabolism_Homo sapiens_hsa006001.65007507
24Butanoate metabolism_Homo sapiens_hsa006501.64158109
25Allograft rejection_Homo sapiens_hsa053301.62946990
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.62536160
27Autoimmune thyroid disease_Homo sapiens_hsa053201.52225056
28Linoleic acid metabolism_Homo sapiens_hsa005911.51788857
29Dorso-ventral axis formation_Homo sapiens_hsa043201.47807242
30Asthma_Homo sapiens_hsa053101.47710406
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.43197384
32Glutathione metabolism_Homo sapiens_hsa004801.40951824
33Hematopoietic cell lineage_Homo sapiens_hsa046401.40268854
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.39291532
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38736849
36Huntingtons disease_Homo sapiens_hsa050161.33280381
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.32958756
38Olfactory transduction_Homo sapiens_hsa047401.30852880
39Nitrogen metabolism_Homo sapiens_hsa009101.26695330
40Arachidonic acid metabolism_Homo sapiens_hsa005901.26649820
41Ovarian steroidogenesis_Homo sapiens_hsa049131.23630023
42Peroxisome_Homo sapiens_hsa041461.22975760
43Glutamatergic synapse_Homo sapiens_hsa047241.22163580
44Calcium signaling pathway_Homo sapiens_hsa040201.20726419
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.18930421
46Propanoate metabolism_Homo sapiens_hsa006401.18016419
47Renin secretion_Homo sapiens_hsa049241.14237034
48Amphetamine addiction_Homo sapiens_hsa050311.13971409
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.13067688
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13034283
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10336127
52Antigen processing and presentation_Homo sapiens_hsa046121.08818456
53Serotonergic synapse_Homo sapiens_hsa047261.08624625
54Taste transduction_Homo sapiens_hsa047421.08373066
55NF-kappa B signaling pathway_Homo sapiens_hsa040641.06749711
56Intestinal immune network for IgA production_Homo sapiens_hsa046721.06717918
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06303017
58Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.04847905
59Morphine addiction_Homo sapiens_hsa050321.04371673
60Maturity onset diabetes of the young_Homo sapiens_hsa049501.03003434
61Steroid hormone biosynthesis_Homo sapiens_hsa001401.02659503
62SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01376623
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99967776
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98873541
65Malaria_Homo sapiens_hsa051440.96735393
66cAMP signaling pathway_Homo sapiens_hsa040240.95052524
67Nucleotide excision repair_Homo sapiens_hsa034200.94551579
68Homologous recombination_Homo sapiens_hsa034400.93804759
69T cell receptor signaling pathway_Homo sapiens_hsa046600.93695122
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92888776
71Rheumatoid arthritis_Homo sapiens_hsa053230.92255538
72Measles_Homo sapiens_hsa051620.91307685
73Other glycan degradation_Homo sapiens_hsa005110.89473515
74Salivary secretion_Homo sapiens_hsa049700.89028959
75Circadian entrainment_Homo sapiens_hsa047130.86185702
76Circadian rhythm_Homo sapiens_hsa047100.84929910
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84761597
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83013729
79Wnt signaling pathway_Homo sapiens_hsa043100.82797942
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82336811
81Inositol phosphate metabolism_Homo sapiens_hsa005620.79702048
82Hippo signaling pathway_Homo sapiens_hsa043900.78919420
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78206938
84Protein export_Homo sapiens_hsa030600.77281015
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77240165
86Parkinsons disease_Homo sapiens_hsa050120.74212198
87Tryptophan metabolism_Homo sapiens_hsa003800.73638849
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.72907673
89Type I diabetes mellitus_Homo sapiens_hsa049400.70448314
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.69934285
91Fatty acid degradation_Homo sapiens_hsa000710.68138864
92Tight junction_Homo sapiens_hsa045300.67009027
93Ras signaling pathway_Homo sapiens_hsa040140.66047033
94Vitamin digestion and absorption_Homo sapiens_hsa049770.65242425
95Axon guidance_Homo sapiens_hsa043600.65190764
96Purine metabolism_Homo sapiens_hsa002300.64253765
97Cocaine addiction_Homo sapiens_hsa050300.64161131
98Insulin secretion_Homo sapiens_hsa049110.63966236
99Oxidative phosphorylation_Homo sapiens_hsa001900.63941493
100Folate biosynthesis_Homo sapiens_hsa007900.63435583
101Oxytocin signaling pathway_Homo sapiens_hsa049210.62644270
102TGF-beta signaling pathway_Homo sapiens_hsa043500.62476798
103Bile secretion_Homo sapiens_hsa049760.62075808
104Mineral absorption_Homo sapiens_hsa049780.61480438
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61165482
106Collecting duct acid secretion_Homo sapiens_hsa049660.60635278
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59976625
108Hedgehog signaling pathway_Homo sapiens_hsa043400.59954768
109ECM-receptor interaction_Homo sapiens_hsa045120.57930657
110Phagosome_Homo sapiens_hsa041450.56895390
111GABAergic synapse_Homo sapiens_hsa047270.56704606
112Regulation of autophagy_Homo sapiens_hsa041400.55338084
113Selenocompound metabolism_Homo sapiens_hsa004500.54232902
114Basal cell carcinoma_Homo sapiens_hsa052170.51825289
115Cardiac muscle contraction_Homo sapiens_hsa042600.51560233
116Metabolic pathways_Homo sapiens_hsa011000.50743454
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.50149976
118Gastric acid secretion_Homo sapiens_hsa049710.49840891
119Alcoholism_Homo sapiens_hsa050340.49562820
120MAPK signaling pathway_Homo sapiens_hsa040100.49241905
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48568316
122Alzheimers disease_Homo sapiens_hsa050100.47861681
123Long-term potentiation_Homo sapiens_hsa047200.47358257
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47138422
125Systemic lupus erythematosus_Homo sapiens_hsa053220.46803187
126Fatty acid elongation_Homo sapiens_hsa000620.45494849
127Cysteine and methionine metabolism_Homo sapiens_hsa002700.44953510
128Glycosaminoglycan degradation_Homo sapiens_hsa005310.44493765
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44211141
130Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44186388
131Long-term depression_Homo sapiens_hsa047300.44092340
132Osteoclast differentiation_Homo sapiens_hsa043800.43879094
133Arginine and proline metabolism_Homo sapiens_hsa003300.43831551
134Choline metabolism in cancer_Homo sapiens_hsa052310.43441418
135Dopaminergic synapse_Homo sapiens_hsa047280.42668747
136NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42098786
137HTLV-I infection_Homo sapiens_hsa051660.41533182
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.41052979
139Chemokine signaling pathway_Homo sapiens_hsa040620.39743692
140Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39111151
141Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39095420
142Oocyte meiosis_Homo sapiens_hsa041140.39028317
143Synaptic vesicle cycle_Homo sapiens_hsa047210.38867678
144Pancreatic secretion_Homo sapiens_hsa049720.38668454
145Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38616995
146RNA degradation_Homo sapiens_hsa030180.37914380
147Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37903851
148Fatty acid biosynthesis_Homo sapiens_hsa000610.30111498

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