CARS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a putative member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of cysteine to tRNA molecules. A splice-site mutation in this gene has been associated with a novel progressive myoclonic epilepsy disease with similar symptoms to MERRF syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thalamus development (GO:0021794)8.48784053
2regulation of type B pancreatic cell apoptotic process (GO:2000674)6.46242367
3protein localization to microtubule (GO:0035372)5.99184918
4negative regulation of synaptic transmission, glutamatergic (GO:0051967)5.96904699
5white fat cell differentiation (GO:0050872)5.71873376
6positive regulation of triglyceride biosynthetic process (GO:0010867)5.48354447
7autophagic vacuole fusion (GO:0000046)5.42470285
8generation of neurons (GO:0048699)5.38880811
9DNA deamination (GO:0045006)5.35999750
10forebrain neuron development (GO:0021884)5.30632523
11ear development (GO:0043583)5.04740144
12negative regulation of Rho protein signal transduction (GO:0035024)4.85160541
13respiratory tube development (GO:0030323)4.83392876
14urinary tract smooth muscle contraction (GO:0014848)4.76770121
15positive regulation of protein export from nucleus (GO:0046827)4.67319914
16positive regulation of glycoprotein biosynthetic process (GO:0010560)4.66078285
17ribosomal small subunit assembly (GO:0000028)4.64123249
18positive regulation of gluconeogenesis (GO:0045722)4.42801437
19UTP biosynthetic process (GO:0006228)4.40709730
20GTP biosynthetic process (GO:0006183)4.38576400
21regulation of triglyceride biosynthetic process (GO:0010866)4.38565685
22positive regulation of protein homooligomerization (GO:0032464)4.35895620
23detection of temperature stimulus involved in sensory perception of pain (GO:0050965)4.34050120
24detection of temperature stimulus involved in sensory perception (GO:0050961)4.34050120
25daunorubicin metabolic process (GO:0044597)4.33018743
26polyketide metabolic process (GO:0030638)4.33018743
27doxorubicin metabolic process (GO:0044598)4.33018743
28regulation of nuclear cell cycle DNA replication (GO:0033262)4.24161704
29oligodendrocyte development (GO:0014003)4.21151704
30protein localization to cytoskeleton (GO:0044380)4.17425320
31deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.11507050
32modulation by virus of host process (GO:0019054)4.03857621
33positive regulation of glycoprotein metabolic process (GO:1903020)3.99419084
34genitalia morphogenesis (GO:0035112)3.98138741
35RNA destabilization (GO:0050779)3.91835017
36tRNA methylation (GO:0030488)3.90848939
37spinal cord motor neuron differentiation (GO:0021522)3.89058171
38organelle membrane fusion (GO:0090174)3.86104255
39telomere maintenance via semi-conservative replication (GO:0032201)3.84143854
40UTP metabolic process (GO:0046051)3.82423597
41behavioral response to cocaine (GO:0048148)3.81187293
42replicative senescence (GO:0090399)3.80174940
43pyrimidine dimer repair (GO:0006290)3.78786524
44positive regulation of triglyceride metabolic process (GO:0090208)3.70535948
45cell junction maintenance (GO:0034331)3.62702695
46cell-cell junction maintenance (GO:0045217)3.57380767
47maturation of SSU-rRNA (GO:0030490)3.56812681
48phosphatidylglycerol biosynthetic process (GO:0006655)3.56635168
49ribosomal small subunit biogenesis (GO:0042274)3.54545483
50import into cell (GO:0098657)3.53772481
51sequestering of actin monomers (GO:0042989)3.46412855
52negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.46245589
53negative regulation of cell killing (GO:0031342)3.46245589
54proteasome assembly (GO:0043248)3.39550531
55termination of RNA polymerase III transcription (GO:0006386)3.37543762
56transcription elongation from RNA polymerase III promoter (GO:0006385)3.37543762
57telomere maintenance via recombination (GO:0000722)3.37351247
58negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.35588636
59ribosomal large subunit biogenesis (GO:0042273)3.32798550
60sleep (GO:0030431)3.29007986
61post-embryonic morphogenesis (GO:0009886)3.26870348
62DNA replication initiation (GO:0006270)3.25658624
63modulation by symbiont of host cellular process (GO:0044068)3.25199195
64detection of temperature stimulus (GO:0016048)3.20646067
65rRNA modification (GO:0000154)3.20455344
66viral transcription (GO:0019083)3.17563159
67embryonic digestive tract morphogenesis (GO:0048557)3.17556251
68central nervous system neuron development (GO:0021954)3.15623185
69regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.12631574
70superoxide anion generation (GO:0042554)3.11773679
71DNA strand elongation involved in DNA replication (GO:0006271)3.11740094
72response to peptidoglycan (GO:0032494)3.11529365
73pseudouridine synthesis (GO:0001522)3.11148441
74protein K6-linked ubiquitination (GO:0085020)3.10598586
75pyrimidine-containing compound transmembrane transport (GO:0072531)3.10014377
76metallo-sulfur cluster assembly (GO:0031163)3.08352259
77iron-sulfur cluster assembly (GO:0016226)3.08352259
78telomere maintenance via telomere lengthening (GO:0010833)3.08317713
79DNA strand elongation (GO:0022616)3.08166079
80translational termination (GO:0006415)3.07167551
81antigen processing and presentation of endogenous antigen (GO:0019883)3.06935445
82RNA methylation (GO:0001510)3.06242060
83tumor necrosis factor-mediated signaling pathway (GO:0033209)3.05313652
84leukocyte aggregation (GO:0070486)3.04663328
85DNA synthesis involved in DNA repair (GO:0000731)3.04542122
86mitotic recombination (GO:0006312)3.00196798
87tRNA modification (GO:0006400)2.99673227
88respiratory chain complex IV assembly (GO:0008535)2.98316065
89regulation of triglyceride metabolic process (GO:0090207)2.97518060
90cellular response to virus (GO:0098586)2.96858821
91cellular response to cholesterol (GO:0071397)2.96674713
92DNA integration (GO:0015074)2.96418901
93regulation of oligodendrocyte differentiation (GO:0048713)2.96381248
94antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.96042818
95granulocyte differentiation (GO:0030851)2.95163505
96pyrimidine nucleobase catabolic process (GO:0006208)2.94224642
97tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.93177890
98RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.93177890
99ribonucleoprotein complex biogenesis (GO:0022613)2.92230737
100kinetochore assembly (GO:0051382)2.90217620
101rRNA methylation (GO:0031167)2.89920245
102positive regulation by symbiont of host defense response (GO:0052509)2.89376294
103modulation by symbiont of host defense response (GO:0052031)2.89376294
104modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.89376294
105modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.89376294
106positive regulation by organism of defense response of other organism involved in symbiotic interact2.89376294
107modulation by symbiont of host immune response (GO:0052553)2.89376294
108regulation of phospholipid biosynthetic process (GO:0071071)2.88135814
109lymphoid progenitor cell differentiation (GO:0002320)2.86241115
110mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.85020034
111positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.85020034
112pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.83966453
113termination of RNA polymerase I transcription (GO:0006363)2.82911614
114negative regulation of potassium ion transport (GO:0043267)2.82777564
115antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.82314905
116deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.82028907
117CENP-A containing nucleosome assembly (GO:0034080)2.80274618
118SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.79829568
119negative regulation of DNA-dependent DNA replication (GO:2000104)2.79741855
120JNK cascade (GO:0007254)2.79161215
121positive regulation of gamma-delta T cell activation (GO:0046645)2.79110426
122rRNA processing (GO:0006364)2.79086880
123antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.78737947
124developmental pigmentation (GO:0048066)2.78732982
125transcription from RNA polymerase I promoter (GO:0006360)2.78379520
126regulation of mitochondrial translation (GO:0070129)2.77785160
127opioid receptor signaling pathway (GO:0038003)2.77461898
128guanosine-containing compound biosynthetic process (GO:1901070)2.77090171
129detection of other organism (GO:0098543)2.75740578
130DNA-dependent DNA replication (GO:0006261)2.74581323
131detection of bacterium (GO:0016045)2.73392641
132aminoglycoside antibiotic metabolic process (GO:0030647)2.73285274
133CTP biosynthetic process (GO:0006241)2.73240380
134CTP metabolic process (GO:0046036)2.73240380
135centriole assembly (GO:0098534)2.72844170
136DNA replication checkpoint (GO:0000076)2.71436401
137regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.70660042
138exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.70477049
139rRNA metabolic process (GO:0016072)2.69682954
140cotranslational protein targeting to membrane (GO:0006613)2.69502783
141G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.69080145
142negative regulation of organ growth (GO:0046621)2.68697586
143dopamine biosynthetic process (GO:0042416)2.67384521
144protein targeting to ER (GO:0045047)2.67040091
145transcription elongation from RNA polymerase I promoter (GO:0006362)2.65193925
146artery smooth muscle contraction (GO:0014824)2.65003869
147chromatin remodeling at centromere (GO:0031055)2.64808323
148diacylglycerol metabolic process (GO:0046339)2.64401812
149quinone biosynthetic process (GO:1901663)2.61362872
150ubiquinone biosynthetic process (GO:0006744)2.61362872
151nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.58885287
152mitochondrial DNA replication (GO:0006264)2.58617649
153tRNA processing (GO:0008033)2.57436870
154cellular component biogenesis (GO:0044085)2.56102558
155protein localization to endoplasmic reticulum (GO:0070972)2.56047860
156translational elongation (GO:0006414)2.54772560
157regulation of sulfur metabolic process (GO:0042762)2.54730762
158ribosome biogenesis (GO:0042254)2.54279865
159establishment of protein localization to endoplasmic reticulum (GO:0072599)2.53838286
160nucleotide-excision repair, DNA gap filling (GO:0006297)2.53775343
161regulation of double-strand break repair via homologous recombination (GO:0010569)2.53667186
162maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.52961333
163transcription-coupled nucleotide-excision repair (GO:0006283)2.52735466
164DNA ligation (GO:0006266)2.52722625
165mature B cell differentiation involved in immune response (GO:0002313)2.52712126
166regulation of ARF protein signal transduction (GO:0032012)2.52138701
167pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.51441632
168cytochrome complex assembly (GO:0017004)2.51184128
169kinetochore organization (GO:0051383)2.51099866
170cellular protein complex disassembly (GO:0043624)2.49942613
171ribosome assembly (GO:0042255)2.49819610
172response to interferon-beta (GO:0035456)2.49690663
173pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.49268422
174ncRNA processing (GO:0034470)2.47519861
175telomere organization (GO:0032200)2.47513247
176telomere maintenance (GO:0000723)2.46819275
177deoxyribonucleotide biosynthetic process (GO:0009263)2.46553860
178response to testosterone (GO:0033574)2.46531565
179maturation of 5.8S rRNA (GO:0000460)2.46452134
180positive regulation of DNA-dependent DNA replication (GO:2000105)2.45922844
181mismatch repair (GO:0006298)2.43259057
182RNA modification (GO:0009451)2.43252777
183transcription initiation from RNA polymerase I promoter (GO:0006361)2.43185196
184negative regulation of telomere maintenance (GO:0032205)2.41597070
185regulation of mitotic spindle checkpoint (GO:1903504)2.40720653
186regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.40720653
187amino sugar catabolic process (GO:0046348)2.40689748
188meiotic chromosome segregation (GO:0045132)2.39089372
189definitive hemopoiesis (GO:0060216)2.38367927
190viral life cycle (GO:0019058)2.37530048
191translation (GO:0006412)2.36229717
192mature B cell differentiation (GO:0002335)2.36141648
193positive regulation of protein homodimerization activity (GO:0090073)2.34816413

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.51404571
2VDR_21846776_ChIP-Seq_THP-1_Human3.85170496
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.76758535
4NOTCH1_21737748_ChIP-Seq_TLL_Human3.27285448
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.27117405
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.16519006
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.01718891
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.00444683
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.93419313
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.85924389
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.81806719
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.76730047
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.65872291
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.57730809
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.56087016
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.55574084
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.55547265
18RUNX_20019798_ChIP-Seq_JUKART_Human2.55059322
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.51087329
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.48168961
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.41793951
22ERG_21242973_ChIP-ChIP_JURKAT_Human2.40048366
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.37964435
24VDR_24763502_ChIP-Seq_THP-1_Human2.37687116
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.36267245
26* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.35555227
27SRF_21415370_ChIP-Seq_HL-1_Mouse2.33098177
28MYC_22102868_ChIP-Seq_BL_Human2.32538433
29TP63_19390658_ChIP-ChIP_HaCaT_Human2.31891398
30BP1_19119308_ChIP-ChIP_Hs578T_Human2.28318618
31ETS1_20019798_ChIP-Seq_JURKAT_Human2.26375438
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.26238337
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.25854051
34MYC_18358816_ChIP-ChIP_MESCs_Mouse2.25588012
35VDR_23849224_ChIP-Seq_CD4+_Human2.25410306
36* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24448771
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.16182393
38IRF8_22096565_ChIP-ChIP_GC-B_Human2.15091743
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.12455904
40KDM2B_26808549_Chip-Seq_DND41_Human2.11639078
41FOXP3_21729870_ChIP-Seq_TREG_Human2.07058539
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.02758245
43MYC_19079543_ChIP-ChIP_MESCs_Mouse2.01498516
44MYC_19030024_ChIP-ChIP_MESCs_Mouse1.99247154
45MAF_26560356_Chip-Seq_TH2_Human1.95234686
46SCL_19346495_ChIP-Seq_HPC-7_Human1.94135399
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.92727088
48LXR_22292898_ChIP-Seq_THP-1_Human1.92397495
49EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91343889
50SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.84768682
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84086079
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.83905810
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.80816595
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.79527381
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.79491685
56MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.77811841
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.72025903
58ELK3_25401928_ChIP-Seq_HUVEC_Human1.71216489
59PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.66148401
60MAF_26560356_Chip-Seq_TH1_Human1.65510180
61IRF1_19129219_ChIP-ChIP_H3396_Human1.65441407
62IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.65146469
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.63503361
64TCF7_22412390_ChIP-Seq_EML_Mouse1.63156558
65P68_20966046_ChIP-Seq_HELA_Human1.62374951
66MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.61503720
67BCL6_27268052_Chip-Seq_Bcells_Human1.61268777
68JARID2_20064375_ChIP-Seq_MESCs_Mouse1.57511121
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.56784900
70EZH2_22144423_ChIP-Seq_EOC_Human1.56339676
71SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.54401622
72* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.54256244
73UTX_26944678_Chip-Seq_JUKART_Human1.53752488
74CREB1_15753290_ChIP-ChIP_HEK293T_Human1.52871384
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.52793424
76TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.52669003
77ELK1_19687146_ChIP-ChIP_HELA_Human1.52356825
78FOXM1_23109430_ChIP-Seq_U2OS_Human1.51812177
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50660064
80SUZ12_27294783_Chip-Seq_ESCs_Mouse1.49852613
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.48965002
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48813062
83SPI1_23547873_ChIP-Seq_NB4_Human1.48060622
84E2F1_21310950_ChIP-Seq_MCF-7_Human1.48000442
85NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47290127
86EED_16625203_ChIP-ChIP_MESCs_Mouse1.47127656
87DCP1A_22483619_ChIP-Seq_HELA_Human1.46890594
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.45636420
89PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45068629
90DROSHA_22980978_ChIP-Seq_HELA_Human1.44552691
91CTCF_27219007_Chip-Seq_ERYTHROID_Human1.43643143
92THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42765622
93CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.42463220
94KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.42449647
95TTF2_22483619_ChIP-Seq_HELA_Human1.42262372
96EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.41987468
97E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41474852
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.41106829
99E2F1_20622854_ChIP-Seq_HELA_Human1.40260706
100TET1_21451524_ChIP-Seq_MESCs_Mouse1.39858203
101SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39420848
102* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.37726584
103IRF8_21731497_ChIP-ChIP_J774_Mouse1.37510215
104MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.37117062
105SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.35367907
106SA1_27219007_Chip-Seq_ERYTHROID_Human1.35360718
107BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34716829
108DNAJC2_21179169_ChIP-ChIP_NT2_Human1.34319591
109KDM2B_26808549_Chip-Seq_JURKAT_Human1.32512697
110CTCF_27219007_Chip-Seq_Bcells_Human1.31550939
111JARID2_20075857_ChIP-Seq_MESCs_Mouse1.30305910
112SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30293935
113NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29284730
114STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29149191
115BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28566253
116EZH2_27294783_Chip-Seq_ESCs_Mouse1.27984560
117MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.27190595
118XRN2_22483619_ChIP-Seq_HELA_Human1.26185714
119SPI1_23127762_ChIP-Seq_K562_Human1.24189092
120CIITA_25753668_ChIP-Seq_RAJI_Human1.24168814
121SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24078048
122CTCF_20526341_ChIP-Seq_ESCs_Human1.23147920
123* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21886865
124KDM2B_26808549_Chip-Seq_K562_Human1.20281682
125VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19811592
126YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19741685
127GATA1_19941827_ChIP-Seq_MEL_Mouse1.18985516
128SA1_27219007_Chip-Seq_Bcells_Human1.18389111
129RNF2_27304074_Chip-Seq_ESCs_Mouse1.17558043
130MYC_18940864_ChIP-ChIP_HL60_Human1.17228511
131SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16418965
132* GABP_19822575_ChIP-Seq_HepG2_Human1.15920954
133KAP1_22055183_ChIP-Seq_ESCs_Mouse1.15680867
134ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15171726
135STAT1_20625510_ChIP-Seq_HELA_Human1.14360071
136CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14309306
137CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.14176995
138PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13916474
139GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13202040
140* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11293798
141CREB1_26743006_Chip-Seq_LNCaP_Human1.10985574
142ELK4_26923725_Chip-Seq_MESODERM_Mouse1.10186081
143EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07316024
144NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05293985
145TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05081342
146EZH2_27294783_Chip-Seq_NPCs_Mouse1.04958780
147TP63_22573176_ChIP-Seq_HFKS_Human1.03676708
148* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.03390723
149PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02933511
150TAF2_19829295_ChIP-Seq_ESCs_Human1.01870543
151POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01747668
152* FOXP1_21924763_ChIP-Seq_HESCs_Human1.01744036
153EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01680244
154SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01464411
155CTCF_26484167_Chip-Seq_Bcells_Mouse1.01041902
156PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00808316
157P53_21459846_ChIP-Seq_SAOS-2_Human1.00748287
158PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99809641
159ELF1_20517297_ChIP-Seq_JURKAT_Human0.99741332
160BCOR_27268052_Chip-Seq_Bcells_Human0.99608941
161TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98110302
162MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98019381
163SPI1_20517297_ChIP-Seq_HL60_Human0.97851688
164GATA1_22025678_ChIP-Seq_K562_Human0.97758294
165GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96986555
166VDR_24787735_ChIP-Seq_THP-1_Human0.94590537
167SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94415058
168RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93451470
169GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88939794
170POU5F1_16153702_ChIP-ChIP_HESCs_Human0.88614035
171* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88515968
172MYB_26560356_Chip-Seq_TH1_Human0.86069844
173POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.86027773
174STAT3_18555785_Chip-Seq_ESCs_Mouse0.85444234
175GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84060855
176RUNX1_27457419_Chip-Seq_LIVER_Mouse0.83393111
177ZFX_18555785_Chip-Seq_ESCs_Mouse0.80707475
178STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.80432613
179STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.79399968
180RUNX1_22412390_ChIP-Seq_EML_Mouse0.78626198
181NMYC_18555785_Chip-Seq_ESCs_Mouse0.76775678

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004510_myositis5.50502892
2MP0008057_abnormal_DNA_replication3.25419467
3MP0006292_abnormal_olfactory_placode3.14573365
4MP0008058_abnormal_DNA_repair2.87402566
5MP0002396_abnormal_hematopoietic_system2.87089534
6MP0001188_hyperpigmentation2.82729490
7MP0003693_abnormal_embryo_hatching2.72917256
8MP0006082_CNS_inflammation2.60342443
9MP0005075_abnormal_melanosome_morpholog2.60220408
10MP0010094_abnormal_chromosome_stability2.59071115
11MP0004381_abnormal_hair_follicle2.53777965
12MP0003111_abnormal_nucleus_morphology2.52151625
13MP0005174_abnormal_tail_pigmentation2.51493993
14MP0001529_abnormal_vocalization2.45442889
15MP0001835_abnormal_antigen_presentation2.28291588
16MP0002933_joint_inflammation2.26941240
17MP0000015_abnormal_ear_pigmentation2.23482284
18MP0002733_abnormal_thermal_nociception2.18508410
19MP0002127_abnormal_cardiovascular_syste2.15882692
20MP0003136_yellow_coat_color2.14635919
21MP0002822_catalepsy2.13187547
22MP0009379_abnormal_foot_pigmentation2.11471351
23MP0005671_abnormal_response_to2.07006482
24MP0003941_abnormal_skin_development2.05634043
25MP0003763_abnormal_thymus_physiology2.04765558
26MP0000490_abnormal_crypts_of2.02961237
27MP0005409_darkened_coat_color2.01507262
28MP0001986_abnormal_taste_sensitivity1.93215585
29MP0003724_increased_susceptibility_to1.93061155
30MP0003786_premature_aging1.92678373
31MP0002132_abnormal_respiratory_system1.89717964
32MP0001905_abnormal_dopamine_level1.81620390
33MP0003077_abnormal_cell_cycle1.81004314
34MP0004858_abnormal_nervous_system1.79798211
35MP0009785_altered_susceptibility_to1.78232047
36MP0002277_abnormal_respiratory_mucosa1.78063321
37MP0000566_synostosis1.71772018
38MP0001663_abnormal_digestive_system1.71163677
39MP0004859_abnormal_synaptic_plasticity1.69818709
40MP0001873_stomach_inflammation1.69509803
41MP0008007_abnormal_cellular_replicative1.66345579
42MP0001533_abnormal_skeleton_physiology1.64290080
43MP0002095_abnormal_skin_pigmentation1.61821026
44MP0001800_abnormal_humoral_immune1.60569845
45MP0003880_abnormal_central_pattern1.59463056
46MP0000751_myopathy1.55876319
47MP0003938_abnormal_ear_development1.55286138
48MP0002102_abnormal_ear_morphology1.52635043
49MP0005025_abnormal_response_to1.51848802
50MP0002148_abnormal_hypersensitivity_rea1.50789760
51MP0005257_abnormal_intraocular_pressure1.49390165
52MP0002723_abnormal_immune_serum1.48781802
53MP0003718_maternal_effect1.48370033
54MP0002452_abnormal_antigen_presenting1.43960969
55MP0005310_abnormal_salivary_gland1.42620847
56MP0002398_abnormal_bone_marrow1.41705937
57MP0005000_abnormal_immune_tolerance1.41218004
58MP0005377_hearing/vestibular/ear_phenot1.40633806
59MP0003878_abnormal_ear_physiology1.40633806
60MP0002420_abnormal_adaptive_immunity1.38244213
61MP0001819_abnormal_immune_cell1.37720332
62MP0005670_abnormal_white_adipose1.35911825
63MP0004808_abnormal_hematopoietic_stem1.35860032
64MP0000372_irregular_coat_pigmentation1.34421294
65MP0000013_abnormal_adipose_tissue1.31905510
66MP0001853_heart_inflammation1.31468910
67MP0008995_early_reproductive_senescence1.30883454
68MP0004742_abnormal_vestibular_system1.27754955
69MP0000689_abnormal_spleen_morphology1.27226278
70MP0001545_abnormal_hematopoietic_system1.26338922
71MP0005397_hematopoietic_system_phenotyp1.26338922
72MP0005464_abnormal_platelet_physiology1.25736939
73MP0001970_abnormal_pain_threshold1.25339252
74MP0009333_abnormal_splenocyte_physiolog1.25302262
75MP0002722_abnormal_immune_system1.25293793
76MP0002419_abnormal_innate_immunity1.25117265
77MP0005387_immune_system_phenotype1.24173049
78MP0001790_abnormal_immune_system1.24173049
79MP0003868_abnormal_feces_composition1.23614292
80MP0008260_abnormal_autophagy1.22821825
81MP0000716_abnormal_immune_system1.22341197
82MP0004947_skin_inflammation1.22240757
83MP0005076_abnormal_cell_differentiation1.18266896
84MP0005423_abnormal_somatic_nervous1.17316220
85MP0002009_preneoplasia1.16583979
86MP0005381_digestive/alimentary_phenotyp1.14342635
87MP0003828_pulmonary_edema1.14119410
88MP0003646_muscle_fatigue1.13329560
89MP0001968_abnormal_touch/_nociception1.12011380
90MP0000703_abnormal_thymus_morphology1.11792589
91MP0000613_abnormal_salivary_gland1.10843634
92MP0000465_gastrointestinal_hemorrhage1.10261351
93MP0001851_eye_inflammation1.10023047
94MP0002429_abnormal_blood_cell1.09587563
95MP0004147_increased_porphyrin_level1.09084514
96MP0004957_abnormal_blastocyst_morpholog1.05679363
97MP0000685_abnormal_immune_system1.03919780
98MP0004145_abnormal_muscle_electrophysio1.03477076
99MP0002638_abnormal_pupillary_reflex1.01751674
100MP0010155_abnormal_intestine_physiology1.01016278
101MP0003303_peritoneal_inflammation1.00433969
102MP0001186_pigmentation_phenotype1.00298868
103MP0002075_abnormal_coat/hair_pigmentati0.98184391
104MP0004782_abnormal_surfactant_physiolog0.97582557
105MP0002938_white_spotting0.97384272
106MP0000371_diluted_coat_color0.97228269
107MP0003279_aneurysm0.96544510
108MP0005451_abnormal_body_composition0.96378603
109MP0003866_abnormal_defecation0.95982582
110MP0002735_abnormal_chemical_nociception0.93280241
111MP0003122_maternal_imprinting0.93145893
112MP0002405_respiratory_system_inflammati0.92398356
113MP0008932_abnormal_embryonic_tissue0.90110289
114MP0000470_abnormal_stomach_morphology0.89791813
115MP0002998_abnormal_bone_remodeling0.89518373
116MP0006035_abnormal_mitochondrial_morpho0.89000561
117MP0000313_abnormal_cell_death0.88401254
118MP0000049_abnormal_middle_ear0.86899264
119MP0000681_abnormal_thyroid_gland0.86442095
120MP0003436_decreased_susceptibility_to0.85261170
121MP0000858_altered_metastatic_potential0.83806704
122MP0004924_abnormal_behavior0.83258677
123MP0005386_behavior/neurological_phenoty0.83258677
124MP0000631_abnormal_neuroendocrine_gland0.82788769
125MP0003186_abnormal_redox_activity0.81652159
126MP0001664_abnormal_digestion0.81517007
127MP0001346_abnormal_lacrimal_gland0.81508196
128MP0002332_abnormal_exercise_endurance0.78231673
129MP0002019_abnormal_tumor_incidence0.77449755
130MP0001764_abnormal_homeostasis0.77403964
131MP0002138_abnormal_hepatobiliary_system0.76329964
132MP0005390_skeleton_phenotype0.75430909
133MP0001845_abnormal_inflammatory_respons0.75411354
134MP0009764_decreased_sensitivity_to0.74879942
135MP0005379_endocrine/exocrine_gland_phen0.74703813
136MP0005171_absent_coat_pigmentation0.74108237
137MP0003948_abnormal_gas_homeostasis0.73976504
138MP0008469_abnormal_protein_level0.73818150
139MP0009697_abnormal_copulation0.73271362
140MP0005220_abnormal_exocrine_pancreas0.72780747
141MP0001919_abnormal_reproductive_system0.72760498
142MP0008004_abnormal_stomach_pH0.72385317
143MP0002210_abnormal_sex_determination0.70862394
144MP0003879_abnormal_hair_cell0.70311577
145MP0002736_abnormal_nociception_after0.70233573
146MP0004883_abnormal_blood_vessel0.70160786
147MP0008874_decreased_physiological_sensi0.69782265
148MP0000537_abnormal_urethra_morphology0.66172052
149MP0000003_abnormal_adipose_tissue0.65130670
150MP0002106_abnormal_muscle_physiology0.64245517
151MP0009840_abnormal_foam_cell0.63318616
152MP0009278_abnormal_bone_marrow0.62447521
153MP0000026_abnormal_inner_ear0.62135517
154MP0005266_abnormal_metabolism0.58427954
155MP0005375_adipose_tissue_phenotype0.58335466
156MP0005389_reproductive_system_phenotype0.57930338
157MP0003635_abnormal_synaptic_transmissio0.56148552

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.22264744
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.09095765
3Chromsome breakage (HP:0040012)4.81420138
4Cerebellar dysplasia (HP:0007033)4.74479418
5Increased IgE level (HP:0003212)4.41156681
6Tetany (HP:0001281)4.24760649
7Reticulocytopenia (HP:0001896)4.14511288
8Pelvic girdle muscle weakness (HP:0003749)4.08945836
9Shoulder girdle muscle weakness (HP:0003547)3.69792300
10Duplicated collecting system (HP:0000081)3.68720470
11Difficulty climbing stairs (HP:0003551)3.65481190
12Abnormality of the renal collecting system (HP:0004742)3.56198678
13Eczematoid dermatitis (HP:0000976)3.48425812
14Abnormality of the hip-girdle musculature (HP:0001445)3.44214332
15Abnormality of the musculature of the pelvis (HP:0001469)3.44214332
16Prostate neoplasm (HP:0100787)3.42650619
17Congenital sensorineural hearing impairment (HP:0008527)3.37208753
18Chronic bronchitis (HP:0004469)3.31979918
19Recurrent bacterial skin infections (HP:0005406)3.30826637
20Type I transferrin isoform profile (HP:0003642)3.25561951
21Birth length less than 3rd percentile (HP:0003561)3.21875428
22Oligodontia (HP:0000677)3.21830592
23Neoplasm of the heart (HP:0100544)3.20293320
24Reduced antithrombin III activity (HP:0001976)3.18205247
25Albinism (HP:0001022)3.13651083
26Amblyopia (HP:0000646)3.12078110
27Recurrent viral infections (HP:0004429)3.11122422
28Abnormality of the preputium (HP:0100587)3.05914739
29Recurrent gram-negative bacterial infections (HP:0005420)3.05878407
30Striae distensae (HP:0001065)3.03997244
31Heterotopia (HP:0002282)3.03944419
32Abnormality of DNA repair (HP:0003254)3.03682759
33Abnormal number of erythroid precursors (HP:0012131)3.01859505
34Recurrent skin infections (HP:0001581)2.99908800
35Partial agenesis of the corpus callosum (HP:0001338)2.98712549
36Follicular hyperkeratosis (HP:0007502)2.92383876
37Abnormality of the prostate (HP:0008775)2.92181502
38Constricted visual fields (HP:0001133)2.89744298
39Abnormality of cells of the erythroid lineage (HP:0012130)2.85584641
40Thrombocytosis (HP:0001894)2.85229864
41Epileptic encephalopathy (HP:0200134)2.83539009
42Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.81652977
43Myotonia (HP:0002486)2.80318094
44Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.79640279
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.79216488
46Abnormality of chromosome stability (HP:0003220)2.78459942
47Prolonged bleeding time (HP:0003010)2.74944841
48Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.73471724
49Hypomagnesemia (HP:0002917)2.73470695
50Meckel diverticulum (HP:0002245)2.73412605
51Clubbing of toes (HP:0100760)2.72186117
523-Methylglutaconic aciduria (HP:0003535)2.71804888
53Microvesicular hepatic steatosis (HP:0001414)2.68155844
54Abnormality of the ileum (HP:0001549)2.66406350
55Akinesia (HP:0002304)2.62254027
56Muscle fiber splitting (HP:0003555)2.57947495
57Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.54516893
58Abnormal protein N-linked glycosylation (HP:0012347)2.54516893
59Abnormal protein glycosylation (HP:0012346)2.54516893
60Abnormal glycosylation (HP:0012345)2.54516893
61Pallor (HP:0000980)2.53893472
62Renal cortical cysts (HP:0000803)2.51928513
63Aplastic anemia (HP:0001915)2.48732849
64Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.46553569
65Gastrointestinal stroma tumor (HP:0100723)2.43761813
66Abnormality of magnesium homeostasis (HP:0004921)2.38761789
67Testicular atrophy (HP:0000029)2.38524102
68Petechiae (HP:0000967)2.37329895
69Pancytopenia (HP:0001876)2.34850294
70Bone marrow hypocellularity (HP:0005528)2.29694012
71Abnormal respiratory motile cilium physiology (HP:0012261)2.29494344
72Chronic mucocutaneous candidiasis (HP:0002728)2.26881691
73Recurrent cutaneous fungal infections (HP:0011370)2.26881691
74Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.24857291
75Slow saccadic eye movements (HP:0000514)2.24488557
76Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.23635716
77Abnormality of the heme biosynthetic pathway (HP:0010472)2.22914106
78Rhinitis (HP:0012384)2.20905490
79Cheilitis (HP:0100825)2.19195145
80Absent rod-and cone-mediated responses on ERG (HP:0007688)2.18129433
81Panhypogammaglobulinemia (HP:0003139)2.16905632
82Type 2 muscle fiber atrophy (HP:0003554)2.16123634
83Myelodysplasia (HP:0002863)2.15110713
84IgM deficiency (HP:0002850)2.14639179
85Purpura (HP:0000979)2.14156792
86Absent thumb (HP:0009777)2.13686437
87Abnormal delayed hypersensitivity skin test (HP:0002963)2.13567896
88Orchitis (HP:0100796)2.11961218
89Exercise-induced myalgia (HP:0003738)2.11882527
90Mediastinal lymphadenopathy (HP:0100721)2.11793521
91Abnormality of the endocardium (HP:0004306)2.10499296
92Decreased activity of mitochondrial respiratory chain (HP:0008972)2.10003709
93Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.10003709
94Recurrent abscess formation (HP:0002722)2.07184059
95Poikiloderma (HP:0001029)2.05817949
96Ectopic kidney (HP:0000086)2.05486383
97Increased hepatocellular lipid droplets (HP:0006565)2.04280101
98Hypochromic anemia (HP:0001931)2.03829227
99Patchy hypopigmentation of hair (HP:0011365)2.03507921
100Short phalanx of the thumb (HP:0009660)2.03371631
101Dry hair (HP:0011359)2.02297162
102Mildly elevated creatine phosphokinase (HP:0008180)2.00188947
103Milia (HP:0001056)1.99742730
104Down-sloping shoulders (HP:0200021)1.99721493
105Abnormality of T cell physiology (HP:0011840)1.99243523
106Spontaneous abortion (HP:0005268)1.99014431
107Muscle fiber atrophy (HP:0100295)1.98841565
108Acute lymphatic leukemia (HP:0006721)1.98561799
109Increased neuronal autofluorescent lipopigment (HP:0002074)1.98344089
110Ocular albinism (HP:0001107)1.98198067
111Intellectual disability, severe (HP:0010864)1.98045264
112Macrocytic anemia (HP:0001972)1.97158461
113Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.97014073
114Short 4th metacarpal (HP:0010044)1.97014073
115Granulocytopenia (HP:0001913)1.96717667
116Microretrognathia (HP:0000308)1.96164332
117Congenital, generalized hypertrichosis (HP:0004540)1.95463869
118Abnormality of the sella turcica (HP:0002679)1.94640050
119Hypergonadotropic hypogonadism (HP:0000815)1.93649068
120Encephalitis (HP:0002383)1.92285105
121Hypochromic microcytic anemia (HP:0004840)1.91133397
122Aplasia/Hypoplasia of the sacrum (HP:0008517)1.91126414
123T lymphocytopenia (HP:0005403)1.91026857
124Premature graying of hair (HP:0002216)1.89042723
125Cellulitis (HP:0100658)1.88929433
126Retrobulbar optic neuritis (HP:0100654)1.88752815
127Optic neuritis (HP:0100653)1.88752815
128Neoplasm of head and neck (HP:0012288)1.88733451
129Esophageal neoplasm (HP:0100751)1.88733451
130Abnormality of macrophages (HP:0004311)1.88385626
131Abnormality of the carotid arteries (HP:0005344)1.88073273
132Lymphopenia (HP:0001888)1.87795640
133Lip pit (HP:0100267)1.87562671
134Exertional dyspnea (HP:0002875)1.87293661
135Agammaglobulinemia (HP:0004432)1.85880910
136Basal cell carcinoma (HP:0002671)1.85606967
137Elevated erythrocyte sedimentation rate (HP:0003565)1.85450361
138Limb-girdle muscle atrophy (HP:0003797)1.85359525
139Increased cerebral lipofuscin (HP:0011813)1.84048665
140Agitation (HP:0000713)1.83602510
141Meningitis (HP:0001287)1.83314672
142Small intestinal stenosis (HP:0012848)1.82800899
143Duodenal stenosis (HP:0100867)1.82800899
144Hemiplegia (HP:0002301)1.82610922
145Abnormality of the columella (HP:0009929)1.81894815
146Aplasia cutis congenita (HP:0001057)1.81581472
147Breast hypoplasia (HP:0003187)1.81411716
148Hypoplasia of the fovea (HP:0007750)1.80302772
149Aplasia/Hypoplasia of the fovea (HP:0008060)1.80302772
150Focal motor seizures (HP:0011153)1.78776070
151Abnormality of male internal genitalia (HP:0000022)1.78448244
152Pustule (HP:0200039)1.78412665
153Fatigue (HP:0012378)1.78163823
154White forelock (HP:0002211)1.77720454
155Recurrent fungal infections (HP:0002841)1.77425827
156Osteomalacia (HP:0002749)1.77083777
157Myositis (HP:0100614)1.76700291
158Duplication of thumb phalanx (HP:0009942)1.76673097
159Broad face (HP:0000283)1.76512824
160IgG deficiency (HP:0004315)1.75412583
161Chronic obstructive pulmonary disease (HP:0006510)1.75048412
162Obstructive lung disease (HP:0006536)1.75048412
163Waddling gait (HP:0002515)1.74827764
164Triphalangeal thumb (HP:0001199)1.74475961
165Abnormality of the axillary hair (HP:0100134)1.74128400
166Abnormality of secondary sexual hair (HP:0009888)1.74128400
167Bronchitis (HP:0012387)1.74128109
168Chronic otitis media (HP:0000389)1.70829572
169Lymphoma (HP:0002665)1.70676941
170Increased serum lactate (HP:0002151)1.70598522
171Ureteral duplication (HP:0000073)1.70487651
172B lymphocytopenia (HP:0010976)1.69601419
173Abnormality of B cell number (HP:0010975)1.69601419
174Renal Fanconi syndrome (HP:0001994)1.68918386
175Abnormal spermatogenesis (HP:0008669)1.68182262
176Hyperalaninemia (HP:0003348)1.67799503
177Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.67799503
178Abnormality of alanine metabolism (HP:0010916)1.67799503
179Recurrent pneumonia (HP:0006532)1.67503942

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK5.40016000
2STK164.61866057
3IRAK34.11472300
4MARK13.52718316
5NME23.25464163
6IRAK43.09703438
7ZAK2.99664225
8TNIK2.32625877
9TXK2.18099301
10EIF2AK21.98105030
11VRK11.93203557
12WEE11.92570432
13IRAK11.91766683
14MAP3K91.91098735
15SRPK11.89700125
16IRAK21.88532051
17MKNK21.83688000
18SIK11.74932742
19CASK1.69447379
20MUSK1.69269249
21PLK41.66072461
22PIK3CA1.64725685
23EIF2AK31.57498868
24BLK1.54066184
25MST1R1.53915331
26MAP4K11.53210643
27MAP3K141.49950774
28TEC1.45914754
29ADRBK21.42549538
30BUB11.41744358
31ACVR1B1.32247456
32KIT1.28246347
33NLK1.28027835
34MKNK11.28018779
35GRK61.25709281
36RIPK41.25364612
37CLK11.24247185
38FLT31.22154904
39TRIM281.21895948
40EPHA21.21682645
41MARK21.21298703
42KSR21.21220379
43PINK11.21199314
44MAP3K111.19195868
45IKBKE1.18819998
46CDK81.18356047
47BTK1.15002394
48BRD41.13557025
49TLK11.13443637
50TYK21.12889316
51GRK11.11763869
52IKBKB1.10188684
53MAP2K31.07891260
54PIM21.06311348
55CDK71.02726796
56YES11.01589944
57DYRK21.00754521
58PRPF4B0.98494394
59KSR10.98269464
60ATR0.98011124
61JAK30.96725735
62DYRK30.94717279
63EPHB20.93460272
64TTK0.93171099
65BMPR1B0.92359716
66ERN10.92085007
67CDK30.89909494
68CHEK20.89731314
69JAK10.89591086
70PAK60.86443888
71TSSK60.84953069
72EIF2AK10.84473353
73TAOK30.83943679
74TIE10.83363824
75INSRR0.82802171
76SIK20.81983651
77CAMKK10.81934876
78PIM10.80708847
79SGK20.80142954
80SGK4940.79329089
81SGK2230.79329089
82BCKDK0.79326198
83PLK10.76345085
84LYN0.75644218
85AURKB0.75144781
86CAMK40.74122704
87UHMK10.74099799
88RPS6KB20.73037723
89STK40.72441868
90PHKG10.71047337
91PHKG20.71047337
92MAPKAPK30.70926007
93SYK0.70638432
94PIK3CG0.69959855
95SIK30.69126794
96NEK20.68623554
97SGK30.68532403
98CDK40.68289354
99MAP3K70.68125018
100CSF1R0.66801544
101RAF10.66582506
102TRIB30.61906401
103MAPK130.61664650
104GRK70.58500260
105MAPK120.57966648
106RPS6KA50.57405671
107CDC70.55847878
108CDK90.55393202
109NTRK20.54480739
110FGR0.53547363
111TNK20.53538862
112NEK60.53396345
113MAP2K60.51883889
114NUAK10.51429919
115LCK0.50169115
116TAOK20.49788330
117TGFBR20.49696879
118MAPK40.48014882
119CSK0.46656190
120NEK90.45277688
121NME10.45260811
122MAP3K130.45135233
123HCK0.44732850
124PASK0.44046676
125ZAP700.43782862
126MAP2K10.43436365
127CHUK0.43242127
128CDC42BPA0.41945901
129TGFBR10.41075977
130MAPK150.40776588
131MAP3K10.39986332
132TBK10.39973284
133STK38L0.39047531
134PRKD20.38966764
135TAOK10.38900329
136TRPM70.38405287
137CSNK2A10.37717711
138FYN0.37688542
139TTN0.36975502
140AKT30.36482222
141FES0.35783102
142EPHA40.35681475
143ATM0.35678317
144MAP2K70.35191835
145AURKA0.35026793
146MYLK0.34263427
147BRSK20.34119948
148RPS6KL10.33234603
149RPS6KC10.33234603
150RPS6KA60.32599378
151SGK10.32223984
152DYRK1A0.31290647
153LRRK20.28554622
154CAMK10.28125298
155PKN10.28069104
156ADRBK10.26822495
157PTK60.22831571
158ITK0.20437484
159PAK30.18819800
160RPS6KA10.17659175
161MAP2K40.17149830
162EGFR0.16552887
163MAPK30.16271693
164MTOR0.15266910
165PRKCQ0.15184935
166MATK0.15046323
167PRKAA20.14776900

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.76089547
2Ribosome_Homo sapiens_hsa030103.64200147
3Homologous recombination_Homo sapiens_hsa034403.15499209
4RNA polymerase_Homo sapiens_hsa030203.15037075
5Fanconi anemia pathway_Homo sapiens_hsa034603.10348558
6Mismatch repair_Homo sapiens_hsa034303.03685855
7Basal cell carcinoma_Homo sapiens_hsa052172.77751056
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.61606308
9Pyrimidine metabolism_Homo sapiens_hsa002402.54026896
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.51438939
11Base excision repair_Homo sapiens_hsa034102.49048510
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.44707332
13Spliceosome_Homo sapiens_hsa030402.12529156
14Non-homologous end-joining_Homo sapiens_hsa034502.03155007
15Nucleotide excision repair_Homo sapiens_hsa034202.02926647
16Primary immunodeficiency_Homo sapiens_hsa053401.88050486
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.87788160
18Proteasome_Homo sapiens_hsa030501.75863179
19Staphylococcus aureus infection_Homo sapiens_hsa051501.73180242
20One carbon pool by folate_Homo sapiens_hsa006701.73019380
21Colorectal cancer_Homo sapiens_hsa052101.71159491
22Basal transcription factors_Homo sapiens_hsa030221.70960263
23Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.64386421
24Endometrial cancer_Homo sapiens_hsa052131.63379960
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.60252858
26Hedgehog signaling pathway_Homo sapiens_hsa043401.60225711
27Folate biosynthesis_Homo sapiens_hsa007901.54196645
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.52406215
29Purine metabolism_Homo sapiens_hsa002301.50336898
30Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.47931526
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43745354
32Herpes simplex infection_Homo sapiens_hsa051681.41557240
33Protein export_Homo sapiens_hsa030601.39413860
34Hematopoietic cell lineage_Homo sapiens_hsa046401.37500690
35RNA degradation_Homo sapiens_hsa030181.37488734
36Other glycan degradation_Homo sapiens_hsa005111.37158353
37Phagosome_Homo sapiens_hsa041451.36916541
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.34818605
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.33492974
40p53 signaling pathway_Homo sapiens_hsa041151.30654851
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.27265424
42Measles_Homo sapiens_hsa051621.27123858
43RNA transport_Homo sapiens_hsa030131.26512928
44Cell cycle_Homo sapiens_hsa041101.24852295
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.21981118
46Melanogenesis_Homo sapiens_hsa049161.21130193
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19272642
48Tuberculosis_Homo sapiens_hsa051521.16195825
49Toxoplasmosis_Homo sapiens_hsa051451.14939975
50* Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.14371433
51Carbohydrate digestion and absorption_Homo sapiens_hsa049731.10876579
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10471526
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.09423447
54Arachidonic acid metabolism_Homo sapiens_hsa005901.06935514
55Thyroid cancer_Homo sapiens_hsa052161.05809261
56Cocaine addiction_Homo sapiens_hsa050300.97853960
57VEGF signaling pathway_Homo sapiens_hsa043700.97528691
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96853622
59Dorso-ventral axis formation_Homo sapiens_hsa043200.96221056
60Regulation of autophagy_Homo sapiens_hsa041400.95585216
61Vitamin digestion and absorption_Homo sapiens_hsa049770.91624747
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89195408
63Serotonergic synapse_Homo sapiens_hsa047260.88806057
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86647033
65Sphingolipid metabolism_Homo sapiens_hsa006000.85403924
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85344686
67Type I diabetes mellitus_Homo sapiens_hsa049400.84724676
68Prolactin signaling pathway_Homo sapiens_hsa049170.84702830
69Butanoate metabolism_Homo sapiens_hsa006500.84438959
70Epstein-Barr virus infection_Homo sapiens_hsa051690.82785640
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.82178505
72FoxO signaling pathway_Homo sapiens_hsa040680.82136506
73Gap junction_Homo sapiens_hsa045400.82001516
74Oxidative phosphorylation_Homo sapiens_hsa001900.80898263
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80436970
76Allograft rejection_Homo sapiens_hsa053300.79268254
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79050065
78Alcoholism_Homo sapiens_hsa050340.78225548
79Chemokine signaling pathway_Homo sapiens_hsa040620.77816145
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.77547889
81Vitamin B6 metabolism_Homo sapiens_hsa007500.77243524
82Viral myocarditis_Homo sapiens_hsa054160.71838683
83Taste transduction_Homo sapiens_hsa047420.71467599
84TNF signaling pathway_Homo sapiens_hsa046680.69387341
85Asthma_Homo sapiens_hsa053100.69370076
86Influenza A_Homo sapiens_hsa051640.69205936
87Autoimmune thyroid disease_Homo sapiens_hsa053200.68319570
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67311830
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67230606
90Graft-versus-host disease_Homo sapiens_hsa053320.66346828
91Systemic lupus erythematosus_Homo sapiens_hsa053220.65952538
92Calcium signaling pathway_Homo sapiens_hsa040200.63334211
93Huntingtons disease_Homo sapiens_hsa050160.62326121
94Parkinsons disease_Homo sapiens_hsa050120.62171206
95ABC transporters_Homo sapiens_hsa020100.60801913
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60457004
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60449598
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58852167
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.58588043
100Galactose metabolism_Homo sapiens_hsa000520.57506003
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57464821
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.57425849
103Leishmaniasis_Homo sapiens_hsa051400.56680896
104Antigen processing and presentation_Homo sapiens_hsa046120.55685964
105beta-Alanine metabolism_Homo sapiens_hsa004100.54665556
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54415660
107MAPK signaling pathway_Homo sapiens_hsa040100.54047508
108Metabolic pathways_Homo sapiens_hsa011000.52717405
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52589943
110Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52344971
111Apoptosis_Homo sapiens_hsa042100.51481427
112Type II diabetes mellitus_Homo sapiens_hsa049300.49952333
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46336763
114Olfactory transduction_Homo sapiens_hsa047400.46000252
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45924218
116mRNA surveillance pathway_Homo sapiens_hsa030150.45893206
117B cell receptor signaling pathway_Homo sapiens_hsa046620.45352156
118Linoleic acid metabolism_Homo sapiens_hsa005910.45231979
119Platelet activation_Homo sapiens_hsa046110.45059188
120Acute myeloid leukemia_Homo sapiens_hsa052210.44775593
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43606006
122African trypanosomiasis_Homo sapiens_hsa051430.41516793
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40549955
124Sulfur relay system_Homo sapiens_hsa041220.40475779
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39309579
126Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38737122
127Hepatitis B_Homo sapiens_hsa051610.38012409
128Osteoclast differentiation_Homo sapiens_hsa043800.37731031
129Non-small cell lung cancer_Homo sapiens_hsa052230.37630829
130Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36962899
131Notch signaling pathway_Homo sapiens_hsa043300.36228112
132Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36163572
133Rheumatoid arthritis_Homo sapiens_hsa053230.35268174
134Morphine addiction_Homo sapiens_hsa050320.35000722
135Alzheimers disease_Homo sapiens_hsa050100.34763092
136Pentose phosphate pathway_Homo sapiens_hsa000300.34651280
137Hepatitis C_Homo sapiens_hsa051600.34558594
138N-Glycan biosynthesis_Homo sapiens_hsa005100.31911244
139alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30639745
140Fructose and mannose metabolism_Homo sapiens_hsa000510.29316347
141Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28623399
142Glycosaminoglycan degradation_Homo sapiens_hsa005310.26429077
143Glutathione metabolism_Homo sapiens_hsa004800.25049467
144Pertussis_Homo sapiens_hsa051330.24924514
145Malaria_Homo sapiens_hsa051440.24019277
146Phototransduction_Homo sapiens_hsa047440.23572450
147HTLV-I infection_Homo sapiens_hsa051660.23177870
148Viral carcinogenesis_Homo sapiens_hsa052030.22843862
149Legionellosis_Homo sapiens_hsa051340.22602583
150T cell receptor signaling pathway_Homo sapiens_hsa046600.22128928
151Small cell lung cancer_Homo sapiens_hsa052220.20767008

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