CARS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1folic acid-containing compound biosynthetic process (GO:0009396)5.89349271
2regulation of translational fidelity (GO:0006450)5.19419712
3protein localization to kinetochore (GO:0034501)4.88544652
4Golgi transport vesicle coating (GO:0048200)4.86868311
5COPI coating of Golgi vesicle (GO:0048205)4.86868311
6UDP-N-acetylglucosamine metabolic process (GO:0006047)4.58210615
7serine family amino acid biosynthetic process (GO:0009070)4.57324740
8DNA unwinding involved in DNA replication (GO:0006268)4.55586436
9IMP biosynthetic process (GO:0006188)4.51837855
10formation of translation preinitiation complex (GO:0001731)4.51156422
11nuclear pore organization (GO:0006999)4.50566791
12mitotic sister chromatid segregation (GO:0000070)4.41608184
13regulation of gene silencing by RNA (GO:0060966)4.36847434
14regulation of posttranscriptional gene silencing (GO:0060147)4.36847434
15regulation of gene silencing by miRNA (GO:0060964)4.36847434
16nucleobase biosynthetic process (GO:0046112)4.33026891
17intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)4.27265399
18nuclear pore complex assembly (GO:0051292)4.24915293
19mitotic nuclear envelope disassembly (GO:0007077)4.22918384
20tetrahydrofolate metabolic process (GO:0046653)4.13215773
21DNA replication-dependent nucleosome assembly (GO:0006335)4.11255666
22DNA replication-dependent nucleosome organization (GO:0034723)4.11255666
23DNA replication initiation (GO:0006270)4.06421310
24sister chromatid segregation (GO:0000819)4.04520410
25* tRNA aminoacylation for protein translation (GO:0006418)3.99009201
26nuclear envelope disassembly (GO:0051081)3.96752760
27membrane disassembly (GO:0030397)3.96752760
28mitotic metaphase plate congression (GO:0007080)3.91694738
29protein localization to chromosome, centromeric region (GO:0071459)3.89685858
30peptidyl-arginine omega-N-methylation (GO:0035247)3.88902945
31regulation of translational termination (GO:0006449)3.80989128
32* amino acid activation (GO:0043038)3.80913590
33* tRNA aminoacylation (GO:0043039)3.80913590
34DNA strand elongation involved in DNA replication (GO:0006271)3.80345024
35IMP metabolic process (GO:0046040)3.79638069
36purine nucleobase biosynthetic process (GO:0009113)3.73984406
37heterochromatin organization (GO:0070828)3.71420928
38histone arginine methylation (GO:0034969)3.69955900
39regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.69415811
40snRNA processing (GO:0016180)3.59127692
41mitochondrial DNA metabolic process (GO:0032042)3.58447187
42DNA geometric change (GO:0032392)3.57545768
43DNA duplex unwinding (GO:0032508)3.56872511
44DNA strand elongation (GO:0022616)3.56364341
45ribosome biogenesis (GO:0042254)3.51674114
46somatic diversification of immune receptors via somatic mutation (GO:0002566)3.48189065
47somatic hypermutation of immunoglobulin genes (GO:0016446)3.48189065
48L-serine transport (GO:0015825)3.47527509
49maturation of SSU-rRNA (GO:0030490)3.45207158
50DNA replication checkpoint (GO:0000076)3.44058331
51misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.44008588
52endoplasmic reticulum unfolded protein response (GO:0030968)3.43493594
53snRNA metabolic process (GO:0016073)3.41816713
54ribosome assembly (GO:0042255)3.39532307
55regulation of helicase activity (GO:0051095)3.36814630
56regulation of spindle organization (GO:0090224)3.36653744
57peptidyl-arginine methylation (GO:0018216)3.35782276
58peptidyl-arginine N-methylation (GO:0035246)3.35782276
59spliceosomal tri-snRNP complex assembly (GO:0000244)3.35240694
60activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.34451272
61mitotic chromosome condensation (GO:0007076)3.31716564
62aspartate family amino acid biosynthetic process (GO:0009067)3.30822618
63metaphase plate congression (GO:0051310)3.28756583
64regulation of histone H3-K27 methylation (GO:0061085)3.28345335
65retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.27798611
66skin morphogenesis (GO:0043589)3.26912680
67cellular response to unfolded protein (GO:0034620)3.25567125
68pteridine-containing compound biosynthetic process (GO:0042559)3.24303566
69telomere maintenance via semi-conservative replication (GO:0032201)3.24122972
70stress granule assembly (GO:0034063)3.23573443
71meiotic chromosome segregation (GO:0045132)3.22616610
72regulation of centrosome cycle (GO:0046605)3.22463098
73cellular response to topologically incorrect protein (GO:0035967)3.22000466
74folic acid-containing compound metabolic process (GO:0006760)3.21532213
75pore complex assembly (GO:0046931)3.17475118
76homocysteine metabolic process (GO:0050667)3.17325424
77regulation of hippo signaling (GO:0035330)3.15752610
78L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.15633268
79positive regulation of nuclease activity (GO:0032075)3.15466880
80dosage compensation (GO:0007549)3.14697157
81folic acid metabolic process (GO:0046655)3.12967309
82regulation of mitotic spindle organization (GO:0060236)3.11539842
83serine transport (GO:0032329)3.09844972
84regulation of translational elongation (GO:0006448)3.09607388
85iron ion import (GO:0097286)3.09272031
86ER-nucleus signaling pathway (GO:0006984)3.06585525
87mitotic nuclear envelope reassembly (GO:0007084)3.06070819
88nuclear envelope reassembly (GO:0031468)3.06070819
89establishment of chromosome localization (GO:0051303)3.05964240
90positive regulation of SMAD protein import into nucleus (GO:0060391)3.02838187
91paraxial mesoderm development (GO:0048339)3.02614365
92chaperone-mediated protein complex assembly (GO:0051131)3.02338765
93ribonucleoprotein complex biogenesis (GO:0022613)3.01677452
94nuclear envelope organization (GO:0006998)3.00723024
95spliceosomal snRNP assembly (GO:0000387)2.99545555
96pre-miRNA processing (GO:0031054)2.99421181
97positive regulation of chromosome segregation (GO:0051984)2.99382260
98ribosomal large subunit biogenesis (GO:0042273)2.96460565
99regulation of nuclease activity (GO:0032069)2.95519994
100tRNA methylation (GO:0030488)2.95248696
101proline biosynthetic process (GO:0006561)2.92300323
102negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.92221901
103maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.92054307
104regulation of chromosome segregation (GO:0051983)2.90392872
105mitotic recombination (GO:0006312)2.89181254
106telomere maintenance via recombination (GO:0000722)2.88092955
107protein heterotrimerization (GO:0070208)2.87749713
108determination of adult lifespan (GO:0008340)2.86968282
109regulation of centriole replication (GO:0046599)2.85425284
110chromatin assembly (GO:0031497)2.84368710
111telomere maintenance via telomere lengthening (GO:0010833)2.84206152
112protein hydroxylation (GO:0018126)2.82536288
113negative regulation of chromosome segregation (GO:0051985)2.81707156
114positive regulation of histone deacetylation (GO:0031065)2.81192739
115negative regulation of DNA recombination (GO:0045910)2.79761796
116L-serine metabolic process (GO:0006563)2.79149264
117cellular response to glucose starvation (GO:0042149)2.79098764
118establishment of apical/basal cell polarity (GO:0035089)2.77530688
119vesicle coating (GO:0006901)2.77186467
120postreplication repair (GO:0006301)2.76919327
121translational initiation (GO:0006413)2.76611901
122chromatin remodeling at centromere (GO:0031055)2.76416194
123rRNA processing (GO:0006364)2.75925803
124glutamine metabolic process (GO:0006541)2.75281871
125negative regulation of histone methylation (GO:0031061)2.73007608
126DNA conformation change (GO:0071103)2.72984922
127regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.72918860
128protein localization to chromosome (GO:0034502)2.72900045
129tRNA modification (GO:0006400)2.72675900
130spindle checkpoint (GO:0031577)2.72666036
131attachment of spindle microtubules to kinetochore (GO:0008608)2.72624526
132establishment of integrated proviral latency (GO:0075713)2.71750006
133regulation of sister chromatid cohesion (GO:0007063)2.70762223
134kinetochore organization (GO:0051383)2.70758947
135negative regulation of mitotic sister chromatid separation (GO:2000816)2.69973411
136negative regulation of mitotic sister chromatid segregation (GO:0033048)2.69973411
137negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.69973411
138negative regulation of sister chromatid segregation (GO:0033046)2.69973411
139spindle assembly checkpoint (GO:0071173)2.69958703
140chromosome segregation (GO:0007059)2.69926582
141activation of Rac GTPase activity (GO:0032863)2.66335871
142* tRNA metabolic process (GO:0006399)2.66160492
143response to endoplasmic reticulum stress (GO:0034976)2.64092352
144glomerular epithelial cell development (GO:0072310)2.63620643
145COPII vesicle coating (GO:0048208)2.62325160
146ER overload response (GO:0006983)2.60817226
147dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.60547686
148regulation of short-term neuronal synaptic plasticity (GO:0048172)2.59261768
149sulfur amino acid biosynthetic process (GO:0000097)2.57617867
150telomere maintenance via telomerase (GO:0007004)2.57569620
151GDP-mannose metabolic process (GO:0019673)2.54502395
152rRNA transcription (GO:0009303)2.48846804
153ncRNA 3-end processing (GO:0043628)2.48017882
154nucleotide-sugar biosynthetic process (GO:0009226)2.48004198
155snRNA transcription (GO:0009301)2.45550132
156negative regulation of viral release from host cell (GO:1902187)2.44026698
157cell adhesion mediated by integrin (GO:0033627)2.43658707
158protein K48-linked deubiquitination (GO:0071108)2.42607635
159hemidesmosome assembly (GO:0031581)2.42000002
160mRNA cleavage (GO:0006379)2.41803002
161mitochondrial RNA metabolic process (GO:0000959)2.40805734
162synaptic vesicle docking involved in exocytosis (GO:0016081)2.39287252
163positive regulation of CREB transcription factor activity (GO:0032793)2.37163190
164response to unfolded protein (GO:0006986)2.37143509
165natural killer cell mediated immunity (GO:0002228)2.36997328
166natural killer cell mediated cytotoxicity (GO:0042267)2.36997328
167nucleotide-sugar metabolic process (GO:0009225)2.35176178
168regulation of RNA export from nucleus (GO:0046831)2.34494109
169response to topologically incorrect protein (GO:0035966)2.33270193
170protein export from nucleus (GO:0006611)2.32814348

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.89910598
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.23675410
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.22787153
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.48658327
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.23913454
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.21865595
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.90091907
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81269357
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.75911175
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.58868091
11* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.44038066
12* ETS1_20019798_ChIP-Seq_JURKAT_Human2.40249626
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.38901672
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.32600421
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.24976069
16* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.18935893
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.18533114
18XRN2_22483619_ChIP-Seq_HELA_Human2.18251063
19POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.15215935
20NANOG_18555785_ChIP-Seq_MESCs_Mouse2.11294984
21* GABP_17652178_ChIP-ChIP_JURKAT_Human2.08448239
22SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.07026911
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02357195
24MYCN_18555785_ChIP-Seq_MESCs_Mouse2.01472580
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.99880342
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99365033
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.99340732
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.97967650
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94627813
30DCP1A_22483619_ChIP-Seq_HELA_Human1.89407463
31AR_21909140_ChIP-Seq_LNCAP_Human1.85865526
32KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.84987078
33KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.84987078
34KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.84987078
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.82904903
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.82093076
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.80869744
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80643899
39STAT3_1855785_ChIP-Seq_MESCs_Mouse1.79567779
40* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.75593208
41VDR_23849224_ChIP-Seq_CD4+_Human1.70431039
42* ELK3_25401928_ChIP-Seq_HUVEC_Human1.69401061
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.66904389
44ESR1_15608294_ChIP-ChIP_MCF-7_Human1.64472923
45* GABP_19822575_ChIP-Seq_HepG2_Human1.63300027
46* TTF2_22483619_ChIP-Seq_HELA_Human1.61373944
47NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.60491633
48DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.59629688
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.58964566
50MYC_22102868_ChIP-Seq_BL_Human1.58922073
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57602057
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.57486831
53* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.55470673
54KDM5A_27292631_Chip-Seq_BREAST_Human1.54790557
55FOXP3_21729870_ChIP-Seq_TREG_Human1.54562824
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54077127
57TFEB_21752829_ChIP-Seq_HELA_Human1.54022637
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53776872
59* TP53_22127205_ChIP-Seq_IMR90_Human1.53310234
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.50637971
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.49688699
62* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.49400367
63ZNF263_19887448_ChIP-Seq_K562_Human1.48925090
64TCF3_18692474_ChIP-Seq_MEFs_Mouse1.47826303
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47108727
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.46590661
67* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45881060
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.45667664
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.44026423
70KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44007364
71CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.42491552
72ELK1_19687146_ChIP-ChIP_HELA_Human1.42244246
73NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.41718592
74SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.40737189
75CIITA_25753668_ChIP-Seq_RAJI_Human1.40198762
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39463232
77ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.38097030
78SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.33180284
79SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.33180284
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32984478
81RACK7_27058665_Chip-Seq_MCF-7_Human1.27802113
82SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.27541275
83* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27479085
84TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27307496
85DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26010705
86FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.25723126
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.24771635
88NCOR1_26117541_ChIP-Seq_K562_Human1.24113504
89RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24035645
90CHD1_26751641_Chip-Seq_LNCaP_Human1.22261001
91YY1_21170310_ChIP-Seq_MESCs_Mouse1.21858854
92MAF_26560356_Chip-Seq_TH2_Human1.20457200
93MAF_26560356_Chip-Seq_TH1_Human1.20145150
94CLOCK_20551151_ChIP-Seq_293T_Human1.19559558
95HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18990887
96* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18959708
97VDR_21846776_ChIP-Seq_THP-1_Human1.18370040
98NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17662017
99PKCTHETA_26484144_Chip-Seq_BREAST_Human1.16946410
100KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16528636
101NANOG_21062744_ChIP-ChIP_HESCs_Human1.15926460
102TBX5_21415370_ChIP-Seq_HL-1_Mouse1.15039188
103PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14605872
104RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14576727
105NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.13726999
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13346223
107TCF3_18692474_ChIP-Seq_MESCs_Mouse1.12100704
108SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.12027119
109NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.09555549
110WT1_19549856_ChIP-ChIP_CCG9911_Human1.08483745
111OCT4_18692474_ChIP-Seq_MEFs_Mouse1.08417016
112SOX2_18692474_ChIP-Seq_MEFs_Mouse1.07994873
113* ATF3_27146783_Chip-Seq_COLON_Human1.06710524
114TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06705674
115HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06377242
116E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05384211
117EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04366709
118* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04118319
119* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.03994577
120* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03944914
121TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02236499
122NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01990745
123* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01416797
124FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01319882
125STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01279368
126* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00897655
127CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00356508
128SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99559984
129SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99075200
130ELF1_20517297_ChIP-Seq_JURKAT_Human0.97336100
131* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97261430
132UBF1/2_26484160_Chip-Seq_HMECs_Human0.97173425
133NOTCH1_21737748_ChIP-Seq_TLL_Human0.96915760
134SOX2_18692474_ChIP-Seq_MESCs_Mouse0.95699339
135TP63_17297297_ChIP-ChIP_HaCaT_Human0.94897916
136TP63_19390658_ChIP-ChIP_HaCaT_Human0.94835954
137* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94507665
138ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93574375
139BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93131355
140HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93004880
141CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92611817

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.37629280
2MP0004957_abnormal_blastocyst_morpholog4.20616692
3MP0003111_abnormal_nucleus_morphology4.04003389
4MP0002254_reproductive_system_inflammat3.77257321
5MP0010094_abnormal_chromosome_stability3.70090411
6MP0010352_gastrointestinal_tract_polyps3.50711786
7MP0003077_abnormal_cell_cycle3.48516897
8MP0008057_abnormal_DNA_replication3.08940489
9MP0004272_abnormal_basement_membrane2.89571278
10MP0001348_abnormal_lacrimal_gland2.84156176
11MP0003705_abnormal_hypodermis_morpholog2.79892631
12MP0003950_abnormal_plasma_membrane2.73474603
13MP0001730_embryonic_growth_arrest2.56677646
14MP0008932_abnormal_embryonic_tissue2.53083101
15MP0000350_abnormal_cell_proliferation2.48305205
16MP0005451_abnormal_body_composition2.42804094
17MP0003806_abnormal_nucleotide_metabolis2.41034969
18MP0003123_paternal_imprinting2.40055001
19MP0008058_abnormal_DNA_repair2.38177567
20MP0005076_abnormal_cell_differentiation2.35473065
21MP0010307_abnormal_tumor_latency2.28762214
22MP0004858_abnormal_nervous_system2.22291533
23MP0004133_heterotaxia2.17829942
24MP0005083_abnormal_biliary_tract2.14640165
25MP0008007_abnormal_cellular_replicative2.12288154
26MP0001672_abnormal_embryogenesis/_devel2.11962566
27MP0005380_embryogenesis_phenotype2.11962566
28MP0003283_abnormal_digestive_organ2.10213327
29MP0004197_abnormal_fetal_growth/weight/2.04117923
30MP0003890_abnormal_embryonic-extraembry2.04077049
31MP0001873_stomach_inflammation1.97550323
32MP0001697_abnormal_embryo_size1.96802111
33MP0002084_abnormal_developmental_patter1.93878074
34MP0003566_abnormal_cell_adhesion1.92228227
35MP0003984_embryonic_growth_retardation1.90549576
36MP0002088_abnormal_embryonic_growth/wei1.88561642
37MP0002085_abnormal_embryonic_tissue1.86197105
38MP0002080_prenatal_lethality1.83252156
39MP0003119_abnormal_digestive_system1.82504769
40MP0010030_abnormal_orbit_morphology1.78871089
41MP0002060_abnormal_skin_morphology1.78231378
42MP0009840_abnormal_foam_cell1.78190195
43MP0002653_abnormal_ependyma_morphology1.73502524
44MP0008438_abnormal_cutaneous_collagen1.70871413
45MP0002086_abnormal_extraembryonic_tissu1.66802691
46MP0004233_abnormal_muscle_weight1.46428619
47MP0005023_abnormal_wound_healing1.45636862
48MP0003718_maternal_effect1.44852494
49MP0003121_genomic_imprinting1.41728076
50MP0002877_abnormal_melanocyte_morpholog1.41605282
51MP0003941_abnormal_skin_development1.38421555
52MP0002111_abnormal_tail_morphology1.36604979
53MP0005257_abnormal_intraocular_pressure1.34603833
54MP0003959_abnormal_lean_body1.31475751
55MP0003786_premature_aging1.23579199
56MP0000490_abnormal_crypts_of1.23445414
57MP0000313_abnormal_cell_death1.22413871
58MP0008877_abnormal_DNA_methylation1.21988779
59MP0002697_abnormal_eye_size1.21986693
60MP0009053_abnormal_anal_canal1.20996334
61MP0003091_abnormal_cell_migration1.20352361
62MP0002970_abnormal_white_adipose1.20233343
63MP0009384_cardiac_valve_regurgitation1.18557944
64MP0000003_abnormal_adipose_tissue1.18021017
65MP0009333_abnormal_splenocyte_physiolog1.17422813
66MP0000750_abnormal_muscle_regeneration1.16116181
67MP0000537_abnormal_urethra_morphology1.15856804
68MP0004185_abnormal_adipocyte_glucose1.15503418
69MP0003221_abnormal_cardiomyocyte_apopto1.15069018
70MP0000358_abnormal_cell_content/1.11914263
71MP0001849_ear_inflammation1.11681532
72MP0000733_abnormal_muscle_development1.10458919
73MP0003656_abnormal_erythrocyte_physiolo1.10271576
74MP0001243_abnormal_dermal_layer1.07647174
75MP0005670_abnormal_white_adipose1.07558392
76MP0002019_abnormal_tumor_incidence1.05302035
77MP0005384_cellular_phenotype1.02822230
78MP0004264_abnormal_extraembryonic_tissu1.01687285
79MP0005275_abnormal_skin_tensile1.01417229
80MP0005621_abnormal_cell_physiology1.00526606
81MP0000432_abnormal_head_morphology0.95418937
82MP0000569_abnormal_digit_pigmentation0.94738310
83MP0000858_altered_metastatic_potential0.92499703
84MP0001915_intracranial_hemorrhage0.91851507
85MP0009672_abnormal_birth_weight0.90079795
86MP0009780_abnormal_chondrocyte_physiolo0.89548010
87MP0009703_decreased_birth_body0.88264279
88MP0000428_abnormal_craniofacial_morphol0.87994988
89MP0004947_skin_inflammation0.87929482
90MP0010771_integument_phenotype0.87391370
91MP0001293_anophthalmia0.87068639
92MP0003385_abnormal_body_wall0.86552630
93MP0003937_abnormal_limbs/digits/tail_de0.86519332
94MP0009931_abnormal_skin_appearance0.85100439
95MP0001286_abnormal_eye_development0.85093851
96MP0005266_abnormal_metabolism0.84774957
97MP0001216_abnormal_epidermal_layer0.84324493
98MP0000371_diluted_coat_color0.82585715
99MP0003279_aneurysm0.82401774
100MP0005501_abnormal_skin_physiology0.81491150
101MP0005623_abnormal_meninges_morphology0.81463394
102MP0002269_muscular_atrophy0.81164927
103MP0005220_abnormal_exocrine_pancreas0.80651267
104MP0001661_extended_life_span0.79740861
105MP0003115_abnormal_respiratory_system0.77478642
106MP0003787_abnormal_imprinting0.77275598
107MP0000467_abnormal_esophagus_morphology0.76073092
108MP0003755_abnormal_palate_morphology0.75715890
109MP0008260_abnormal_autophagy0.75428984
110MP0005375_adipose_tissue_phenotype0.75306143
111MP0010234_abnormal_vibrissa_follicle0.74551819
112MP0008770_decreased_survivor_rate0.72241085
113MP0003861_abnormal_nervous_system0.72233956
114MP0001958_emphysema0.70497799
115MP0002160_abnormal_reproductive_system0.69822816
116MP0003763_abnormal_thymus_physiology0.68498700
117MP0002295_abnormal_pulmonary_circulatio0.68458413
118MP0001299_abnormal_eye_distance/0.68042532
119MP0003567_abnormal_fetal_cardiomyocyte0.66891402
120MP0001145_abnormal_male_reproductive0.66508451
121MP0002092_abnormal_eye_morphology0.63755915
122MP0002210_abnormal_sex_determination0.63462041
123MP0003935_abnormal_craniofacial_develop0.62063821
124MP0001542_abnormal_bone_strength0.61728780
125MP0002396_abnormal_hematopoietic_system0.61651500
126MP0005310_abnormal_salivary_gland0.60816674
127MP0002925_abnormal_cardiovascular_devel0.59793760
128MP0003453_abnormal_keratinocyte_physiol0.59243832
129MP0003448_altered_tumor_morphology0.59149321
130MP0002177_abnormal_outer_ear0.58487180
131MP0000377_abnormal_hair_follicle0.58208884
132MP0005503_abnormal_tendon_morphology0.58038333
133MP0000678_abnormal_parathyroid_gland0.58012293
134MP0000685_abnormal_immune_system0.57835415
135MP0000703_abnormal_thymus_morphology0.57573307
136MP0003172_abnormal_lysosome_physiology0.57406581
137MP0000013_abnormal_adipose_tissue0.56805284
138MP0005389_reproductive_system_phenotype0.56205774
139MP0005395_other_phenotype0.55886740
140MP0003329_amyloid_beta_deposits0.54268825
141MP0002116_abnormal_craniofacial_bone0.54164221
142MP0000477_abnormal_intestine_morphology0.54095272
143MP0000627_abnormal_mammary_gland0.53885683
144MP0003942_abnormal_urinary_system0.53695057

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.44310552
2Dysmetric saccades (HP:0000641)4.19437516
3Abnormality of the labia minora (HP:0012880)3.53841874
4Astrocytoma (HP:0009592)3.51287385
5Abnormality of the astrocytes (HP:0100707)3.51287385
6Degeneration of anterior horn cells (HP:0002398)3.41745655
7Abnormality of the anterior horn cell (HP:0006802)3.41745655
8Hand muscle atrophy (HP:0009130)3.36127892
9Agnosia (HP:0010524)3.25798097
10Breast hypoplasia (HP:0003187)3.22132341
11Selective tooth agenesis (HP:0001592)3.11328063
12Abnormal gallbladder physiology (HP:0012438)3.09774391
13Cholecystitis (HP:0001082)3.09774391
14Birth length less than 3rd percentile (HP:0003561)3.09567016
15Abnormality of dentin (HP:0010299)3.06980080
16Trismus (HP:0000211)2.92031445
17Medulloblastoma (HP:0002885)2.90482625
18Missing ribs (HP:0000921)2.85320684
19Upper limb amyotrophy (HP:0009129)2.82698091
20Distal upper limb amyotrophy (HP:0007149)2.82698091
21Hyperacusis (HP:0010780)2.82158618
22Abnormality of the calcaneus (HP:0008364)2.79456603
23Insomnia (HP:0100785)2.76989063
24Glioma (HP:0009733)2.72626862
25Carpal bone hypoplasia (HP:0001498)2.70009856
26Protrusio acetabuli (HP:0003179)2.68172989
27Cortical dysplasia (HP:0002539)2.67897023
28Absent radius (HP:0003974)2.66600607
29Follicular hyperkeratosis (HP:0007502)2.66501936
30Atrophic scars (HP:0001075)2.64647853
31Patellar aplasia (HP:0006443)2.64249210
32Rhabdomyosarcoma (HP:0002859)2.63631774
33Colon cancer (HP:0003003)2.62785308
34Deviation of the thumb (HP:0009603)2.62125768
35Nonimmune hydrops fetalis (HP:0001790)2.55650784
36Long palpebral fissure (HP:0000637)2.48721690
37Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.48601788
38Aplasia involving forearm bones (HP:0009822)2.48028472
39Absent forearm bone (HP:0003953)2.48028472
40Flat cornea (HP:0007720)2.45976099
41Biliary tract neoplasm (HP:0100574)2.45563917
42Proximal placement of thumb (HP:0009623)2.44605321
43Aplasia/hypoplasia of the humerus (HP:0006507)2.42024153
44Bowel diverticulosis (HP:0005222)2.41256217
45Aplasia/Hypoplasia of the patella (HP:0006498)2.41015531
46Upper limb muscle weakness (HP:0003484)2.39615185
47Metaphyseal cupping (HP:0003021)2.38466088
48Bladder diverticulum (HP:0000015)2.37903342
49Rib fusion (HP:0000902)2.35145542
50Spinal muscular atrophy (HP:0007269)2.30098265
51Absent thumb (HP:0009777)2.28871273
52Large hands (HP:0001176)2.28623516
53Poikiloderma (HP:0001029)2.28211120
54Hammertoe (HP:0001765)2.26320917
55Angiofibromas (HP:0010615)2.25750968
56Adenoma sebaceum (HP:0009720)2.25750968
57Atrophy/Degeneration involving motor neurons (HP:0007373)2.25573473
58Elbow flexion contracture (HP:0002987)2.23619981
59Chronic bronchitis (HP:0004469)2.22936148
60Spastic diplegia (HP:0001264)2.22500699
61Soft skin (HP:0000977)2.20369765
62Neoplasm of the pancreas (HP:0002894)2.20261434
63Short humerus (HP:0005792)2.20109991
64Hypoplasia of the pons (HP:0012110)2.19886653
65Breech presentation (HP:0001623)2.19202325
66Oral leukoplakia (HP:0002745)2.17973452
67Spinal rigidity (HP:0003306)2.17019534
68Rough bone trabeculation (HP:0100670)2.16937223
69Cerebral hypomyelination (HP:0006808)2.16833796
70Abdominal situs inversus (HP:0003363)2.15351716
71Abnormality of abdominal situs (HP:0011620)2.15351716
72Cervical subluxation (HP:0003308)2.14801507
73Sparse lateral eyebrow (HP:0005338)2.13514151
74Fragile skin (HP:0001030)2.13212656
75Premature rupture of membranes (HP:0001788)2.11035518
76Pelvic girdle muscle weakness (HP:0003749)2.08147688
77Supernumerary spleens (HP:0009799)2.07669994
78Neoplasm of striated muscle (HP:0009728)2.05787546
79Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.05417640
80Abnormality of the salivary glands (HP:0010286)2.04546068
81Impulsivity (HP:0100710)2.04205069
82Shoulder girdle muscle weakness (HP:0003547)2.03371617
83Increased density of long bones (HP:0006392)2.03052652
84Biconcave vertebral bodies (HP:0004586)2.02969387
85Natal tooth (HP:0000695)2.02568783
86Genu recurvatum (HP:0002816)2.02502942
87Chromosomal breakage induced by crosslinking agents (HP:0003221)2.02295125
88Abnormality of subcutaneous fat tissue (HP:0001001)2.02207929
89Chromsome breakage (HP:0040012)2.01724530
90Reticulocytopenia (HP:0001896)1.99658631
91Basal cell carcinoma (HP:0002671)1.99164625
92Abnormal respiratory motile cilium physiology (HP:0012261)1.98436221
93Wrist flexion contracture (HP:0001239)1.97014048
94Neoplasm of the oral cavity (HP:0100649)1.95503776
95Fused cervical vertebrae (HP:0002949)1.95410960
96Meckel diverticulum (HP:0002245)1.94936073
97Ankle contracture (HP:0006466)1.94290072
98Vertebral clefting (HP:0008428)1.93237353
99Vertebral hypoplasia (HP:0008417)1.92285698
100Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.92285698
101Ulnar bowing (HP:0003031)1.91914176
102Cafe-au-lait spot (HP:0000957)1.90095603
103Disproportionate tall stature (HP:0001519)1.90069617
104Multiple enchondromatosis (HP:0005701)1.89974722
105Abnormality of the pons (HP:0007361)1.88940874
106Long foot (HP:0001833)1.88826338
107Abnormality of the ileum (HP:0001549)1.86689884
108Homocystinuria (HP:0002156)1.86501043
109Abnormality of homocysteine metabolism (HP:0010919)1.86501043
110Protruding ear (HP:0000411)1.86301334
111Aplasia/Hypoplasia of the uvula (HP:0010293)1.85989440
11211 pairs of ribs (HP:0000878)1.85923709
113Abnormality of the lower motor neuron (HP:0002366)1.85700462
114Horseshoe kidney (HP:0000085)1.82743287
115Small hand (HP:0200055)1.82680360
116Ankyloglossia (HP:0010296)1.82423949
117Gastrointestinal carcinoma (HP:0002672)1.82147328
118Malignant gastrointestinal tract tumors (HP:0006749)1.82147328
119Abnormal trabecular bone morphology (HP:0100671)1.81499144
120Glossoptosis (HP:0000162)1.81387120
121Congenital hip dislocation (HP:0001374)1.81238764
122Distal sensory impairment (HP:0002936)1.80204172
123Aortic regurgitation (HP:0001659)1.79233630
124Redundant skin (HP:0001582)1.79151181
125Atelectasis (HP:0100750)1.78121699
126Abnormality of chromosome stability (HP:0003220)1.77162840
127Delayed puberty (HP:0000823)1.76686619
128Squamous cell carcinoma (HP:0002860)1.76460447
129Blue sclerae (HP:0000592)1.76130364
130Premature ovarian failure (HP:0008209)1.76086883
131Abnormal number of incisors (HP:0011064)1.75852548
132Abnormality of the preputium (HP:0100587)1.74961455
133Wormian bones (HP:0002645)1.74930463
134Atresia of the external auditory canal (HP:0000413)1.72656610
135Sloping forehead (HP:0000340)1.72104019
136Mild short stature (HP:0003502)1.71748119
137Premature skin wrinkling (HP:0100678)1.71567559
138Increased nuchal translucency (HP:0010880)1.71541348
139Neoplasm of the colon (HP:0100273)1.70546981
140Amaurosis fugax (HP:0100576)1.69872838
141Small intestinal stenosis (HP:0012848)1.69491250
142Duodenal stenosis (HP:0100867)1.69491250
143Genetic anticipation (HP:0003743)1.68971197
144Rhinitis (HP:0012384)1.68834460
145High pitched voice (HP:0001620)1.68400009
146Megalocornea (HP:0000485)1.67169245
147Renal duplication (HP:0000075)1.66216536
148Abnormality of oral frenula (HP:0000190)1.65453223
149Elfin facies (HP:0004428)1.64049613
150Bronchiectasis (HP:0002110)1.63015174
151Pterygium (HP:0001059)1.62863234
152Unilateral renal agenesis (HP:0000122)1.62386310
153Entropion (HP:0000621)1.61204450
154Abnormal ciliary motility (HP:0012262)1.61198597
155Gaze-evoked nystagmus (HP:0000640)1.59099898
156Short nail (HP:0001799)1.57725412
157Long eyelashes (HP:0000527)1.57231216
158Prominent nose (HP:0000448)1.56166314
159Hypoplasia of the capital femoral epiphysis (HP:0003090)1.54793267
160Distal lower limb amyotrophy (HP:0008944)1.53481958
161Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.52977287
162Overriding aorta (HP:0002623)1.52584533
163Decreased motor nerve conduction velocity (HP:0003431)1.51931896
164Dynein arm defect of respiratory motile cilia (HP:0012255)1.50985622
165Absent/shortened dynein arms (HP:0200106)1.50985622
166Vertebral compression fractures (HP:0002953)1.50367057

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA23.85611381
2CDC73.62086811
3BUB13.53924698
4SMG13.02246725
5WEE12.99888488
6NEK12.96568500
7CDK122.94971404
8TSSK62.74735598
9EIF2AK12.53108086
10TTK2.51206387
11MST1R2.47692461
12PASK2.33162291
13IRAK32.28246324
14NEK22.27864815
15FRK1.99016092
16SCYL21.86494530
17PLK11.83240121
18TLK11.82009534
19RPS6KB21.81868665
20PKN21.78302163
21SIK11.77189586
22EEF2K1.73377211
23LATS21.62758865
24SRPK11.61429341
25LMTK21.60810113
26PLK31.58661275
27AURKA1.57303638
28TRIM281.56062563
29CAMK1D1.49621287
30AURKB1.45219956
31SIK21.44947800
32MAP3K81.42990404
33ATR1.41788590
34EPHB11.40572778
35BRSK21.38809541
36CDK71.36230371
37PAK41.36086469
38ALK1.34352291
39RPS6KA41.33311249
40CHEK11.32824210
41TRPM71.32195259
42CHEK21.29870203
43TESK21.27358785
44EIF2AK31.26622013
45AKT31.25405288
46TTN1.23241691
47DDR21.22069359
48STK101.16736783
49CAMK1G1.14478571
50MAP3K101.13600909
51MTOR1.12614543
52NTRK11.11426188
53BCR1.11149291
54CLK11.11049091
55PRKD21.06984008
56BRD41.06194270
57MAP3K71.05725471
58KSR11.05267338
59MARK21.04640788
60MKNK11.04289838
61CDK41.03436345
62FLT31.02276315
63TESK11.00429326
64PRKCI0.98786857
65BMX0.98206157
66CDK20.93930233
67KSR20.93398855
68MAPKAPK30.91878048
69SIK30.90981178
70CDK80.90510225
71MAP3K130.89815744
72STK30.89715139
73STK38L0.86541332
74BRSK10.84341542
75ERN10.83728049
76ADRBK20.82463678
77ATM0.81977672
78ICK0.81752266
79PAK10.80900984
80PLK40.80560789
81NME20.80144204
82MAP2K70.79931770
83RAF10.77678906
84MET0.77173214
85ERBB40.74909540
86PRKAA10.74835890
87MAPK110.73935675
88PAK20.73767329
89STK380.73361708
90PBK0.71220572
91MAP4K20.70760069
92PNCK0.69465778
93HIPK20.69335009
94ACVR1B0.68038338
95CSNK2A20.67368969
96CDK10.66838484
97CDK60.66485479
98PDGFRA0.65853561
99PIM10.65380807
100CSNK1E0.64746247
101MKNK20.64386761
102TGFBR10.63774387
103PDK40.63586938
104PDK30.63586938
105STK40.63321650
106AKT20.62159275
107BRAF0.62099027
108ZAK0.61994638
109TRIB30.60022391
110NME10.59038846
111DYRK20.59017898
112PRPF4B0.58839080
113LRRK20.55682976
114MST40.52920742
115DYRK30.52333578
116PTK60.51239668
117CDK190.50957145
118PTK2B0.50817449
119CSNK2A10.50179781
120PIM20.49114647
121PRKDC0.48629710
122LIMK10.48536874
123FGFR10.47773082
124VRK10.47462484
125ADRBK10.46440159
126DAPK10.45890558
127MELK0.45038632
128BCKDK0.44546635
129CDK90.44153349
130TAOK20.43807417
131PDGFRB0.43417198
132PDK20.42813671
133PTK20.42277308
134LATS10.41028513
135MAP3K90.40553393
136CHUK0.39252487
137PLK20.38795818
138MAP3K140.38542074
139RPS6KB10.37996227
140DAPK30.37781901
141MAP3K110.37500814
142CSNK1A1L0.37095546
143AKT10.35082622
144MAPK140.33551707
145MAP3K60.33045227
146GSK3B0.27156715

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006704.52341539
2* Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009704.37049512
3Mismatch repair_Homo sapiens_hsa034304.07828472
4DNA replication_Homo sapiens_hsa030304.06771365
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.60355220
6RNA transport_Homo sapiens_hsa030133.34632429
7Spliceosome_Homo sapiens_hsa030402.95901119
8Proteasome_Homo sapiens_hsa030502.63347101
9Base excision repair_Homo sapiens_hsa034102.54745026
10Cell cycle_Homo sapiens_hsa041102.42758199
11RNA polymerase_Homo sapiens_hsa030202.34004655
12Nucleotide excision repair_Homo sapiens_hsa034202.33609734
13Homologous recombination_Homo sapiens_hsa034402.23192359
14Ribosome_Homo sapiens_hsa030102.07593829
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.07527341
16mRNA surveillance pathway_Homo sapiens_hsa030151.87062040
17Biosynthesis of amino acids_Homo sapiens_hsa012301.75415385
18Pyrimidine metabolism_Homo sapiens_hsa002401.71962610
19Fanconi anemia pathway_Homo sapiens_hsa034601.69072417
20p53 signaling pathway_Homo sapiens_hsa041151.66886186
21Non-homologous end-joining_Homo sapiens_hsa034501.62937034
22Selenocompound metabolism_Homo sapiens_hsa004501.54850647
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.48998885
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.38429226
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.38307656
26RNA degradation_Homo sapiens_hsa030181.34151600
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.33331805
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.30773366
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.29946419
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26828836
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.25278693
32Viral carcinogenesis_Homo sapiens_hsa052031.22543179
33Epstein-Barr virus infection_Homo sapiens_hsa051691.20198695
34Systemic lupus erythematosus_Homo sapiens_hsa053221.18512290
35Bladder cancer_Homo sapiens_hsa052191.15474238
36Carbon metabolism_Homo sapiens_hsa012001.00761012
37Cysteine and methionine metabolism_Homo sapiens_hsa002700.99802209
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98631268
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98511504
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96954710
41MicroRNAs in cancer_Homo sapiens_hsa052060.96700143
42Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95574624
43Oocyte meiosis_Homo sapiens_hsa041140.90187132
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88500189
45Basal transcription factors_Homo sapiens_hsa030220.88287784
46Hippo signaling pathway_Homo sapiens_hsa043900.85101196
47mTOR signaling pathway_Homo sapiens_hsa041500.80548849
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80071125
49Steroid biosynthesis_Homo sapiens_hsa001000.79357663
50Pancreatic cancer_Homo sapiens_hsa052120.78547080
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.78481318
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77658309
53HTLV-I infection_Homo sapiens_hsa051660.76832574
54AMPK signaling pathway_Homo sapiens_hsa041520.74260542
55ErbB signaling pathway_Homo sapiens_hsa040120.73638623
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71773792
57Fructose and mannose metabolism_Homo sapiens_hsa000510.71276896
58Small cell lung cancer_Homo sapiens_hsa052220.71056746
59Legionellosis_Homo sapiens_hsa051340.69698038
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67943273
61Renal cell carcinoma_Homo sapiens_hsa052110.66181522
62Adherens junction_Homo sapiens_hsa045200.65995912
63Purine metabolism_Homo sapiens_hsa002300.65827153
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.62652282
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62042765
66Pentose phosphate pathway_Homo sapiens_hsa000300.61111906
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59267815
68Insulin resistance_Homo sapiens_hsa049310.58935376
69Folate biosynthesis_Homo sapiens_hsa007900.58167794
70TGF-beta signaling pathway_Homo sapiens_hsa043500.58080548
71Apoptosis_Homo sapiens_hsa042100.57493846
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56333714
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56281075
74Basal cell carcinoma_Homo sapiens_hsa052170.54411424
75Alcoholism_Homo sapiens_hsa050340.54202320
76HIF-1 signaling pathway_Homo sapiens_hsa040660.53761425
77Galactose metabolism_Homo sapiens_hsa000520.53666573
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.53383098
79Insulin signaling pathway_Homo sapiens_hsa049100.52988039
80Measles_Homo sapiens_hsa051620.52663676
81Antigen processing and presentation_Homo sapiens_hsa046120.51971907
82Vitamin B6 metabolism_Homo sapiens_hsa007500.51626644
83Proteoglycans in cancer_Homo sapiens_hsa052050.51137201
84Hepatitis C_Homo sapiens_hsa051600.50731737
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50335562
86Chronic myeloid leukemia_Homo sapiens_hsa052200.49863845
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49820066
88FoxO signaling pathway_Homo sapiens_hsa040680.49302051
89Melanoma_Homo sapiens_hsa052180.49265867
90Colorectal cancer_Homo sapiens_hsa052100.48246936
91Endocytosis_Homo sapiens_hsa041440.47294853
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46453743
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46102044
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.45535922
95N-Glycan biosynthesis_Homo sapiens_hsa005100.44346859
96Prostate cancer_Homo sapiens_hsa052150.43738512
97Pyruvate metabolism_Homo sapiens_hsa006200.43480097
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.41811471
99Vibrio cholerae infection_Homo sapiens_hsa051100.41613124
100Protein export_Homo sapiens_hsa030600.40666191
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.39455077
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39139221
103Tight junction_Homo sapiens_hsa045300.38475923
104TNF signaling pathway_Homo sapiens_hsa046680.38189848
105Herpes simplex infection_Homo sapiens_hsa051680.38000378
106Estrogen signaling pathway_Homo sapiens_hsa049150.37036289
107Notch signaling pathway_Homo sapiens_hsa043300.36849327
108Thyroid cancer_Homo sapiens_hsa052160.36735605
109Type II diabetes mellitus_Homo sapiens_hsa049300.35907209
110Hedgehog signaling pathway_Homo sapiens_hsa043400.33237416
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32559422
112Type I diabetes mellitus_Homo sapiens_hsa049400.32036439
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31434710
114Hepatitis B_Homo sapiens_hsa051610.29164032
115Lysine degradation_Homo sapiens_hsa003100.28710107
116Shigellosis_Homo sapiens_hsa051310.28450483
117Arginine and proline metabolism_Homo sapiens_hsa003300.28033263
118Endometrial cancer_Homo sapiens_hsa052130.26950720
119Focal adhesion_Homo sapiens_hsa045100.26230826
120Pathways in cancer_Homo sapiens_hsa052000.23374483
121Sulfur relay system_Homo sapiens_hsa041220.23117337
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19784083
123Acute myeloid leukemia_Homo sapiens_hsa052210.18697772
124ECM-receptor interaction_Homo sapiens_hsa045120.18282023
125Glutathione metabolism_Homo sapiens_hsa004800.17745366
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16451960
127Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15815422
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.14998451
129Phagosome_Homo sapiens_hsa041450.14804462

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »