CARD17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)7.22311512
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.72719912
3neutrophil activation involved in immune response (GO:0002283)5.58657169
4immunoglobulin mediated immune response (GO:0016064)4.95184400
5Arp2/3 complex-mediated actin nucleation (GO:0034314)4.90691522
6neutrophil activation (GO:0042119)4.62410741
7positive regulation of gamma-delta T cell activation (GO:0046645)4.54250368
8regulation of T cell tolerance induction (GO:0002664)4.52148778
9positive regulation of natural killer cell mediated immunity (GO:0002717)4.48200761
10regulation of natural killer cell mediated immunity (GO:0002715)4.47145186
11regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.47145186
12mast cell activation (GO:0045576)4.46440937
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.42559772
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.38498872
15respiratory burst (GO:0045730)4.35168509
16positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.32640894
17antigen processing and presentation via MHC class Ib (GO:0002475)4.32624489
18actin nucleation (GO:0045010)4.32229803
19positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.32178693
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.32117465
21negative regulation of cell killing (GO:0031342)4.32117465
22negative T cell selection (GO:0043383)4.28952560
23negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.20285343
24cellular response to interleukin-15 (GO:0071350)4.19494087
25regulation of tolerance induction (GO:0002643)4.18411108
26antigen processing and presentation of endogenous antigen (GO:0019883)4.13796037
27granulocyte activation (GO:0036230)4.09206961
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.08030023
29positive T cell selection (GO:0043368)4.03178898
30T cell costimulation (GO:0031295)3.97961917
31B cell mediated immunity (GO:0019724)3.94800489
32positive thymic T cell selection (GO:0045059)3.94060547
33response to interleukin-15 (GO:0070672)3.93087728
34lymphocyte costimulation (GO:0031294)3.92970317
35T cell receptor signaling pathway (GO:0050852)3.78466582
36negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.77125632
37tolerance induction (GO:0002507)3.75048199
38negative thymic T cell selection (GO:0045060)3.71553907
39regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.70348597
40T cell migration (GO:0072678)3.67736152
41positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.67012547
42positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.66201065
43regulation of hypersensitivity (GO:0002883)3.63169289
44positive regulation of tolerance induction (GO:0002645)3.57598966
45regulation of regulatory T cell differentiation (GO:0045589)3.54883813
46regulation of alpha-beta T cell proliferation (GO:0046640)3.54837109
47cellular extravasation (GO:0045123)3.51971400
48interferon-gamma-mediated signaling pathway (GO:0060333)3.51146090
49regulation of leukocyte mediated cytotoxicity (GO:0001910)3.50669868
50type I interferon signaling pathway (GO:0060337)3.49927240
51cellular response to type I interferon (GO:0071357)3.49927240
52leukocyte aggregation (GO:0070486)3.46288870
53response to type I interferon (GO:0034340)3.45435273
54positive regulation of mast cell activation (GO:0033005)3.42989486
55myeloid cell activation involved in immune response (GO:0002275)3.41942713
56antigen receptor-mediated signaling pathway (GO:0050851)3.37063224
57microglial cell activation (GO:0001774)3.35101363
58positive regulation of alpha-beta T cell proliferation (GO:0046641)3.33376126
59regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.30879279
60regulation of vitamin D biosynthetic process (GO:0060556)3.29932693
61positive regulation of mast cell activation involved in immune response (GO:0033008)3.29724513
62positive regulation of mast cell degranulation (GO:0043306)3.29724513
63positive regulation of cell killing (GO:0031343)3.24282956
64positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.24126556
65regulation of interleukin-8 secretion (GO:2000482)3.22474890
66positive regulation of interleukin-1 beta secretion (GO:0050718)3.22227864
67detection of molecule of bacterial origin (GO:0032490)3.21315860
68regulation of mast cell activation (GO:0033003)3.20011933
69thymic T cell selection (GO:0045061)3.18607232
70T cell selection (GO:0045058)3.18086772
71regulation of cell killing (GO:0031341)3.15535106
72negative regulation of T cell mediated immunity (GO:0002710)3.12774757
73regulation of gamma-delta T cell activation (GO:0046643)3.12160843
74positive regulation of interleukin-1 beta production (GO:0032731)3.08205753
75regulation of interleukin-2 biosynthetic process (GO:0045076)3.07219510
76positive regulation of interleukin-8 secretion (GO:2000484)3.07033260
77positive regulation of lymphocyte mediated immunity (GO:0002708)3.06777524
78positive regulation of interleukin-1 secretion (GO:0050716)3.04242969
79mast cell degranulation (GO:0043303)3.02668589
80mast cell activation involved in immune response (GO:0002279)3.02668589
81lymphocyte chemotaxis (GO:0048247)3.01609307
82regulation of interleukin-1 beta secretion (GO:0050706)3.01523392
83negative regulation of interleukin-12 production (GO:0032695)2.98464030
84modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.98442508
85positive regulation by organism of defense response of other organism involved in symbiotic interact2.98442508
86modulation by symbiont of host immune response (GO:0052553)2.98442508
87positive regulation by symbiont of host defense response (GO:0052509)2.98442508
88modulation by symbiont of host defense response (GO:0052031)2.98442508
89modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.98442508
90response to peptidoglycan (GO:0032494)2.97825382
91leukocyte degranulation (GO:0043299)2.96702166
92positive regulation of interleukin-1 production (GO:0032732)2.94926994
93negative regulation of lymphocyte mediated immunity (GO:0002707)2.94073303
94regulation of gamma-delta T cell differentiation (GO:0045586)2.93769329
95positive regulation of uterine smooth muscle contraction (GO:0070474)2.92785185
96positive regulation of fatty acid oxidation (GO:0046321)2.91232370
97positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.89560028
98detection of other organism (GO:0098543)2.89293741
99positive regulation of T cell mediated cytotoxicity (GO:0001916)2.88205686
100positive regulation of type 2 immune response (GO:0002830)2.86639353

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.71463665
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.49254926
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.47405533
4IRF8_21731497_ChIP-ChIP_J774_Mouse5.20430221
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.51568709
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.36814543
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.48291999
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.20587225
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.15978897
10MYB_26560356_Chip-Seq_TH2_Human2.93212249
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.76728525
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.74863526
13RUNX_20019798_ChIP-Seq_JUKART_Human2.70491383
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.60231365
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.50140457
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.45730140
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.43808329
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.31546852
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.21288402
20GATA3_27048872_Chip-Seq_THYMUS_Human2.13506195
21SPI1_23547873_ChIP-Seq_NB4_Human2.08860478
22GATA3_26560356_Chip-Seq_TH2_Human2.08101883
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.06395643
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.95956381
25MYB_26560356_Chip-Seq_TH1_Human1.93809606
26VDR_22108803_ChIP-Seq_LS180_Human1.90739880
27MYB_21317192_ChIP-Seq_ERMYB_Mouse1.88780622
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.82142129
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.80858549
30MAF_26560356_Chip-Seq_TH1_Human1.73796495
31RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.66973815
32SPI1_23127762_ChIP-Seq_K562_Human1.63771628
33UTX_26944678_Chip-Seq_JUKART_Human1.59515275
34HTT_18923047_ChIP-ChIP_STHdh_Human1.55660981
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.46712569
36VDR_24787735_ChIP-Seq_THP-1_Human1.45338883
37RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.44272864
38SCL_19346495_ChIP-Seq_HPC-7_Human1.37952317
39LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.36196926
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33926548
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.33238030
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.32382199
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30053679
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29024206
45GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27832016
46CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.24558132
47MAF_26560356_Chip-Seq_TH2_Human1.22312484
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.18768250
49CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15232148
50VDR_24763502_ChIP-Seq_THP-1_Human1.14457945
51EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14058506
52NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11933913
53EGR1_19032775_ChIP-ChIP_M12_Human1.09095049
54SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07952587
55PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04556113
56TAF15_26573619_Chip-Seq_HEK293_Human1.04452023
57PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02577619
58CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00600794
59ERG_20517297_ChIP-Seq_VCAP_Human0.99891095
60TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99783832
61PU_27001747_Chip-Seq_BMDM_Mouse0.97930179
62EZH2_22144423_ChIP-Seq_EOC_Human0.97418626
63CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95679407
64PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94728887
65FLI1_27457419_Chip-Seq_LIVER_Mouse0.94692956
66NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.93876733
67GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93501883
68SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92498111
69RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.91830726
70BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.90356713
71BCL6_27268052_Chip-Seq_Bcells_Human0.89955543
72VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.89022640
73PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.87363769
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86377619
75BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85507547
76SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83491734
77CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83179749
78STAT1_20625510_ChIP-Seq_HELA_Human0.82458211
79GATA6_21074721_ChIP-Seq_CACO-2_Human0.78603587
80CEBPB_22108803_ChIP-Seq_LS180_Human0.78504074
81GATA2_22383799_ChIP-Seq_G1ME_Mouse0.78411907
82NANOG_19829295_ChIP-Seq_ESCs_Human0.78310962
83SOX2_19829295_ChIP-Seq_ESCs_Human0.78310962
84NFE2_27457419_Chip-Seq_LIVER_Mouse0.77989062
85GATA3_26560356_Chip-Seq_TH1_Human0.77324346
86VDR_23849224_ChIP-Seq_CD4+_Human0.77279230
87GATA3_21878914_ChIP-Seq_MCF-7_Human0.76455847
88PCGF2_27294783_Chip-Seq_ESCs_Mouse0.75957746
89NOTCH1_21737748_ChIP-Seq_TLL_Human0.75248128
90* FOXH1_21741376_ChIP-Seq_EPCs_Human0.74728825
91TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.74082291
92GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.73941658
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73264571
94STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.72835934
95TAF2_19829295_ChIP-Seq_ESCs_Human0.72712136
96CRX_20693478_ChIP-Seq_RETINA_Mouse0.72054141
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.69873312
98SMRT_27268052_Chip-Seq_Bcells_Human0.69650658
99RBPJ_21746931_ChIP-Seq_IB4_Human0.69237822
100GATA2_21666600_ChIP-Seq_HMVEC_Human0.68280872

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition5.07243709
2MP0005671_abnormal_response_to4.77591669
3MP0001835_abnormal_antigen_presentation4.46232212
4MP0003724_increased_susceptibility_to4.26266869
5MP0009785_altered_susceptibility_to3.93222543
6MP0001873_stomach_inflammation3.35064606
7MP0003436_decreased_susceptibility_to3.25573811
8MP0005000_abnormal_immune_tolerance3.21140022
9MP0001800_abnormal_humoral_immune3.02774452
10MP0005025_abnormal_response_to2.90194017
11MP0003763_abnormal_thymus_physiology2.68689958
12MP0002723_abnormal_immune_serum2.68549776
13MP0006082_CNS_inflammation2.65673585
14MP0000685_abnormal_immune_system2.54419831
15MP0005387_immune_system_phenotype2.54273313
16MP0001790_abnormal_immune_system2.54273313
17MP0002419_abnormal_innate_immunity2.50795657
18MP0002452_abnormal_antigen_presenting2.48250849
19MP0002420_abnormal_adaptive_immunity2.47886747
20MP0001819_abnormal_immune_cell2.45267002
21MP0002148_abnormal_hypersensitivity_rea2.37112479
22MP0009333_abnormal_splenocyte_physiolog2.36887195
23MP0002166_altered_tumor_susceptibility2.19349026
24MP0009764_decreased_sensitivity_to2.07763098
25MP0010155_abnormal_intestine_physiology2.05752400
26MP0001533_abnormal_skeleton_physiology1.99133313
27MP0003303_peritoneal_inflammation1.90157947
28MP0005464_abnormal_platelet_physiology1.89513449
29MP0001845_abnormal_inflammatory_respons1.85271546
30MP0003075_altered_response_to1.81772106
31MP0000716_abnormal_immune_system1.80105376
32MP0002006_tumorigenesis1.80093979
33MP0003866_abnormal_defecation1.78452569
34MP0002405_respiratory_system_inflammati1.76477278
35MP0002398_abnormal_bone_marrow1.74736981
36MP0004947_skin_inflammation1.68009025
37MP0003806_abnormal_nucleotide_metabolis1.66368098
38MP0003045_fibrosis1.48516600
39MP0000858_altered_metastatic_potential1.48178044
40MP0003448_altered_tumor_morphology1.43487411
41MP0005166_decreased_susceptibility_to1.40963200
42MP0000689_abnormal_spleen_morphology1.38879468
43MP0002933_joint_inflammation1.37342464
44MP0008469_abnormal_protein_level1.36429975
45MP0002429_abnormal_blood_cell1.35770258
46MP0002722_abnormal_immune_system1.31687605
47MP0000703_abnormal_thymus_morphology1.23920893
48MP0005075_abnormal_melanosome_morpholog1.23701473
49MP0002277_abnormal_respiratory_mucosa1.21581842
50MP0000465_gastrointestinal_hemorrhage1.16617150
51MP0002132_abnormal_respiratory_system1.08398625
52MP0009763_increased_sensitivity_to1.06802428
53MP0008260_abnormal_autophagy1.04449855
54MP0009379_abnormal_foot_pigmentation1.04211631
55MP0001663_abnormal_digestive_system0.98437299
56MP0003252_abnormal_bile_duct0.98233445
57MP0000569_abnormal_digit_pigmentation0.94629494
58MP0000343_altered_response_to0.89299677
59MP0003646_muscle_fatigue0.88285005
60MP0001765_abnormal_ion_homeostasis0.86105311
61MP0008004_abnormal_stomach_pH0.85202812
62MP0003183_abnormal_peptide_metabolism0.84762187
63MP0003300_gastrointestinal_ulcer0.79741232
64MP0001853_heart_inflammation0.77969211
65MP0008961_abnormal_basal_metabolism0.75971389
66MP0004883_abnormal_blood_vessel0.74928276
67MP0002693_abnormal_pancreas_physiology0.73144419
68MP0005390_skeleton_phenotype0.72758342
69MP0001545_abnormal_hematopoietic_system0.72323930
70MP0005397_hematopoietic_system_phenotyp0.72323930
71MP0004381_abnormal_hair_follicle0.70960309
72MP0005645_abnormal_hypothalamus_physiol0.67826149
73MP0001666_abnormal_nutrient_absorption0.66217321
74MP0003690_abnormal_glial_cell0.64134098
75MP0002998_abnormal_bone_remodeling0.63020758
76MP0009278_abnormal_bone_marrow0.62082473
77MP0003283_abnormal_digestive_organ0.62051694
78MP0003191_abnormal_cellular_cholesterol0.61644806
79MP0003938_abnormal_ear_development0.61146319
80MP0003638_abnormal_response/metabolism_0.57943901
81MP0005164_abnormal_response_to0.57523795
82MP0002168_other_aberrant_phenotype0.56302226
83MP0006036_abnormal_mitochondrial_physio0.55953830
84MP0005381_digestive/alimentary_phenotyp0.55793944
85MP0000249_abnormal_blood_vessel0.55259778
86MP0009765_abnormal_xenobiotic_induced0.52520362
87MP0000920_abnormal_myelination0.51995044
88MP0005310_abnormal_salivary_gland0.51872706
89MP0002138_abnormal_hepatobiliary_system0.51347096
90MP0001851_eye_inflammation0.50918698
91MP0002009_preneoplasia0.50891544
92MP0002136_abnormal_kidney_physiology0.49932560
93MP0002019_abnormal_tumor_incidence0.49333434
94MP0005551_abnormal_eye_electrophysiolog0.48483231
95MP0000015_abnormal_ear_pigmentation0.47800243
96MP0004742_abnormal_vestibular_system0.47568576
97MP0001485_abnormal_pinna_reflex0.46347332
98MP0009840_abnormal_foam_cell0.45621480
99MP0008875_abnormal_xenobiotic_pharmacok0.45508621
100MP0005174_abnormal_tail_pigmentation0.45038413

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.70559300
2B lymphocytopenia (HP:0010976)5.20011202
3Abnormality of macrophages (HP:0004311)5.10799125
4IgG deficiency (HP:0004315)5.10234364
5Stomatitis (HP:0010280)4.95303543
6Increased IgM level (HP:0003496)4.86939712
7Abnormality of B cell number (HP:0010975)4.83720879
8Autoimmune hemolytic anemia (HP:0001890)4.75611485
9Gastrointestinal infarctions (HP:0005244)4.70305374
10Obstructive lung disease (HP:0006536)4.56152677
11Chronic obstructive pulmonary disease (HP:0006510)4.56152677
12Myositis (HP:0100614)4.27061502
13T lymphocytopenia (HP:0005403)4.20692663
14Mediastinal lymphadenopathy (HP:0100721)4.10686141
15Meningitis (HP:0001287)4.00832439
16Abnormality of T cell number (HP:0011839)3.95749708
17Abnormality of the prostate (HP:0008775)3.90776633
18Eczematoid dermatitis (HP:0000976)3.81062221
19Chest pain (HP:0100749)3.72371184
20Recurrent bacterial skin infections (HP:0005406)3.63527466
21Encephalitis (HP:0002383)3.62880973
22Recurrent abscess formation (HP:0002722)3.58262189
23Gangrene (HP:0100758)3.55423694
24Orchitis (HP:0100796)3.53185731
25Hypoproteinemia (HP:0003075)3.52843609
26Optic neuritis (HP:0100653)3.50025937
27Retrobulbar optic neuritis (HP:0100654)3.50025937
28Pulmonary infiltrates (HP:0002113)3.39936123
29Hemoptysis (HP:0002105)3.36958989
30Vasculitis (HP:0002633)3.33828612
31Aplastic anemia (HP:0001915)3.32008160
32Absent rod-and cone-mediated responses on ERG (HP:0007688)3.25834407
33Severe combined immunodeficiency (HP:0004430)3.16395455
34Recurrent bronchitis (HP:0002837)3.12293150
35Ureteral stenosis (HP:0000071)3.11508959
36Pulmonary embolism (HP:0002204)3.05786092
37Arterial thrombosis (HP:0004420)3.03362429
38Acute hepatic failure (HP:0006554)3.01958383
39Recurrent fungal infections (HP:0002841)2.99061051
40Recurrent cutaneous fungal infections (HP:0011370)2.98992800
41Chronic mucocutaneous candidiasis (HP:0002728)2.98992800
42Abnormality of binocular vision (HP:0011514)2.90376637
43Diplopia (HP:0000651)2.90376637
44Hypergammaglobulinemia (HP:0010702)2.89663363
45Ureteral obstruction (HP:0006000)2.85575561
46Recurrent skin infections (HP:0001581)2.85225388
47Epistaxis (HP:0000421)2.82403562
48Thyroiditis (HP:0100646)2.77321344
49Abnormality of T cells (HP:0002843)2.74052085
50Lymphopenia (HP:0001888)2.71805198
51Recurrent gram-negative bacterial infections (HP:0005420)2.70136139
52Interstitial pulmonary disease (HP:0006530)2.63675116
53Combined immunodeficiency (HP:0005387)2.59195219
54Polyneuropathy (HP:0001271)2.56552112
55Abnormality of cells of the lymphoid lineage (HP:0012140)2.49090569
56Keratoconjunctivitis sicca (HP:0001097)2.48166677
57Anorexia (HP:0002039)2.43680081
58Skin rash (HP:0000988)2.43344865
59Abnormal rod and cone electroretinograms (HP:0008323)2.42069448
60Abnormality of the pleura (HP:0002103)2.38069200
61Keratoconjunctivitis (HP:0001096)2.37405326
62Severe visual impairment (HP:0001141)2.36437716
63Gingival bleeding (HP:0000225)2.34755491
64Decreased central vision (HP:0007663)2.32534816
65Abnormality of male internal genitalia (HP:0000022)2.30015720
66Glomerulopathy (HP:0100820)2.29685390
67Pancytopenia (HP:0001876)2.29232969
68Leukocytosis (HP:0001974)2.28315085
69IgM deficiency (HP:0002850)2.23700574
70Prolonged bleeding time (HP:0003010)2.21225880
71Urticaria (HP:0001025)2.18323933
72Amaurosis fugax (HP:0100576)2.17687646
73Chronic diarrhea (HP:0002028)2.16179246
74Vertigo (HP:0002321)2.15114740
75Hypochromic microcytic anemia (HP:0004840)2.13151044
76Thrombophlebitis (HP:0004418)2.10141760
77Bronchitis (HP:0012387)2.09038870
78Pulmonary fibrosis (HP:0002206)2.08145827
79Abnormality of eosinophils (HP:0001879)2.07644109
80Generalized aminoaciduria (HP:0002909)2.05835472
81Lymphoma (HP:0002665)2.05575112
82Abnormality of the pericardium (HP:0001697)2.02806872
83Recurrent sinusitis (HP:0011108)2.00603773
84Alveolar cell carcinoma (HP:0006519)2.00511992
85Increased serum ferritin (HP:0003281)1.99391120
86Keratitis (HP:0000491)1.95491408
87Restrictive lung disease (HP:0002091)1.93660908
88Joint swelling (HP:0001386)1.92332770
89Radial bowing (HP:0002986)1.90412270
90Recurrent otitis media (HP:0000403)1.90321771
91Increased IgE level (HP:0003212)1.89461453
92Episodic fever (HP:0001954)1.88085218
93Autoimmune thrombocytopenia (HP:0001973)1.87782579
94Hypoplasia of the thymus (HP:0000778)1.83007597
95Chronic otitis media (HP:0000389)1.79952762
96Hypochromic anemia (HP:0001931)1.79231390
97Abnormal delayed hypersensitivity skin test (HP:0002963)1.77058179
98Increased corneal curvature (HP:0100692)1.76612330
99Keratoconus (HP:0000563)1.76612330
100Stomach cancer (HP:0012126)1.76514871

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.30314234
2KDR3.79249462
3CDK193.41108554
4RIPK43.17172564
5TEC2.97044794
6MAP4K12.93375697
7BMPR22.77157237
8SCYL22.70557550
9TESK22.63929726
10GRK62.52748667
11ITK2.41134863
12CSK2.37718145
13MAP3K122.24366960
14JAK32.21149776
15BTK2.13815668
16BLK2.08567707
17TAOK32.05951584
18ZAP701.99842395
19TYK21.98359509
20PIK3CG1.96959095
21SYK1.76555641
22LYN1.67436027
23TLK11.65768974
24FES1.64800457
25ZAK1.48132896
26JAK21.43057943
27TBK11.42906749
28LCK1.42896909
29CSF1R1.38981349
30MYLK1.33274903
31JAK11.31325076
32IKBKE1.28846520
33CDK81.28641716
34KIT1.26805016
35TRPM71.24975818
36LRRK21.20967711
37HCK1.15602107
38MAP3K101.14867639
39IRAK41.14711094
40GRK11.04517312
41MAP3K111.02761938
42IKBKB0.99991535
43ERN10.93271128
44CAMKK20.92463545
45NEK90.86078016
46FYN0.85742920
47SIK30.85346202
48MATK0.84629706
49FGR0.83809347
50OXSR10.83774275
51ILK0.80971191
52MAP3K140.77684274
53PIM10.76936271
54IRAK10.72502114
55ERBB30.69732711
56ROCK10.67114513
57IGF1R0.66954690
58ADRBK20.66904605
59FRK0.63564203
60ERBB20.63523653
61GRK70.61907329
62PRKD30.61306253
63TAOK20.59961291
64PRKCH0.57854307
65CAMKK10.57571161
66EPHB10.55291212
67MAP3K10.55052355
68ABL10.51972406
69PASK0.51074915
70MAP2K60.50215197
71CDK40.49819551
72MAP2K30.48630378
73PTK2B0.48232768
74MARK30.47980055
75TIE10.46828933
76MAP3K50.46311510
77PRKCD0.46254784
78PKN10.44500768
79PAK10.43654237
80PRKD20.43230879
81PRKCQ0.41738725
82MAP4K20.41731021
83WNK10.40376568
84TNK20.38291123
85PDK10.36123067
86HIPK20.35562059
87MAP3K70.35339917
88EGFR0.34996443
89TESK10.33753887
90DAPK30.33599062
91NUAK10.30543019
92RPS6KA50.29957739
93VRK10.29336580
94DYRK1B0.27894552
95PRKCA0.27731901
96PAK40.23798117
97PRKD10.23781573
98ADRBK10.21760689
99PRPF4B0.20580353
100LATS10.20359997

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.14295282
2Graft-versus-host disease_Homo sapiens_hsa053323.73004588
3Autoimmune thyroid disease_Homo sapiens_hsa053203.72747084
4Allograft rejection_Homo sapiens_hsa053303.67927274
5Asthma_Homo sapiens_hsa053103.34334716
6Type I diabetes mellitus_Homo sapiens_hsa049403.09349674
7Antigen processing and presentation_Homo sapiens_hsa046122.86745513
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.75784692
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.63485211
10Staphylococcus aureus infection_Homo sapiens_hsa051502.58203211
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.58079341
12Leishmaniasis_Homo sapiens_hsa051402.53801330
13Hematopoietic cell lineage_Homo sapiens_hsa046402.48590083
14T cell receptor signaling pathway_Homo sapiens_hsa046602.29690736
15Malaria_Homo sapiens_hsa051442.25626446
16Viral myocarditis_Homo sapiens_hsa054162.00588393
17Rheumatoid arthritis_Homo sapiens_hsa053231.98617848
18Measles_Homo sapiens_hsa051621.96698360
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.82875987
20Osteoclast differentiation_Homo sapiens_hsa043801.75018411
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.66715127
22Legionellosis_Homo sapiens_hsa051341.65792368
23Tuberculosis_Homo sapiens_hsa051521.56103635
24Proteasome_Homo sapiens_hsa030501.47606590
25Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.40391164
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.38489162
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.32848504
28Influenza A_Homo sapiens_hsa051641.28041038
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.23078190
30Oxidative phosphorylation_Homo sapiens_hsa001901.22225181
31Toxoplasmosis_Homo sapiens_hsa051451.19793496
32Salmonella infection_Homo sapiens_hsa051321.16295710
33African trypanosomiasis_Homo sapiens_hsa051431.14562284
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07764352
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05779455
36Shigellosis_Homo sapiens_hsa051311.02520255
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01095313
38Herpes simplex infection_Homo sapiens_hsa051680.98033189
39Chemokine signaling pathway_Homo sapiens_hsa040620.97506159
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96273838
41Phagosome_Homo sapiens_hsa041450.95404075
42Pertussis_Homo sapiens_hsa051330.94569822
43Parkinsons disease_Homo sapiens_hsa050120.93208431
44Jak-STAT signaling pathway_Homo sapiens_hsa046300.86705134
45TNF signaling pathway_Homo sapiens_hsa046680.85907278
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84519254
47Platelet activation_Homo sapiens_hsa046110.81656676
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81451505
49Systemic lupus erythematosus_Homo sapiens_hsa053220.80056584
50Collecting duct acid secretion_Homo sapiens_hsa049660.75633504
51Ribosome_Homo sapiens_hsa030100.73223019
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72984037
53B cell receptor signaling pathway_Homo sapiens_hsa046620.69916859
54Olfactory transduction_Homo sapiens_hsa047400.67603269
55One carbon pool by folate_Homo sapiens_hsa006700.63697216
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59511124
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.58047412
58Nitrogen metabolism_Homo sapiens_hsa009100.52690470
59Endocytosis_Homo sapiens_hsa041440.52520455
60Alzheimers disease_Homo sapiens_hsa050100.50722937
61Apoptosis_Homo sapiens_hsa042100.48199045
62Epstein-Barr virus infection_Homo sapiens_hsa051690.47509624
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46449455
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45044964
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42137383
66Arachidonic acid metabolism_Homo sapiens_hsa005900.41151561
67Regulation of autophagy_Homo sapiens_hsa041400.40697074
68ABC transporters_Homo sapiens_hsa020100.39578908
69Phototransduction_Homo sapiens_hsa047440.38552966
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37229411
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36981698
72HTLV-I infection_Homo sapiens_hsa051660.34551904
73Linoleic acid metabolism_Homo sapiens_hsa005910.31397061
74Hepatitis C_Homo sapiens_hsa051600.30428175
75Cardiac muscle contraction_Homo sapiens_hsa042600.29656427
76Hepatitis B_Homo sapiens_hsa051610.28267135
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27432771
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27163983
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27036175
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.26199431
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22684190
82Ether lipid metabolism_Homo sapiens_hsa005650.22057665
83Acute myeloid leukemia_Homo sapiens_hsa052210.18606885
84Taste transduction_Homo sapiens_hsa047420.17686979
85Sphingolipid metabolism_Homo sapiens_hsa006000.17524228
86Dorso-ventral axis formation_Homo sapiens_hsa043200.15907923
87Huntingtons disease_Homo sapiens_hsa050160.15318245
88Prolactin signaling pathway_Homo sapiens_hsa049170.13032530
89Renal cell carcinoma_Homo sapiens_hsa052110.11097840
90MAPK signaling pathway_Homo sapiens_hsa040100.11081054
91Viral carcinogenesis_Homo sapiens_hsa052030.09563207
92Peroxisome_Homo sapiens_hsa041460.09242586
93Ras signaling pathway_Homo sapiens_hsa040140.07317303
94PPAR signaling pathway_Homo sapiens_hsa033200.07105590
95Pancreatic cancer_Homo sapiens_hsa052120.06377537
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.06359929
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.06248491
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.05426019
99Amoebiasis_Homo sapiens_hsa051460.05250514
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.04599425

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »