CARD10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular visceral epithelial cell development (GO:0072015)6.73113810
2glomerular epithelial cell development (GO:0072310)6.04469262
3glomerular basement membrane development (GO:0032836)5.54913354
4bundle of His cell to Purkinje myocyte communication (GO:0086069)5.22170672
5hemidesmosome assembly (GO:0031581)4.82326960
6intestinal absorption (GO:0050892)4.32875920
7vascular endothelial growth factor signaling pathway (GO:0038084)4.20951164
8lysine catabolic process (GO:0006554)4.20744097
9lysine metabolic process (GO:0006553)4.20744097
10regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.03441442
11epithelial cell-cell adhesion (GO:0090136)4.00835158
12desmosome organization (GO:0002934)3.90049907
13renal filtration (GO:0097205)3.89563489
14regulation of hippo signaling (GO:0035330)3.88663190
15lymphangiogenesis (GO:0001946)3.86667875
16cell migration involved in sprouting angiogenesis (GO:0002042)3.63343627
17surfactant homeostasis (GO:0043129)3.60868728
18very-low-density lipoprotein particle assembly (GO:0034379)3.59905527
19regulation of bile acid biosynthetic process (GO:0070857)3.58085816
20lymph vessel development (GO:0001945)3.57868785
21blood vessel endothelial cell migration (GO:0043534)3.51701469
22proline biosynthetic process (GO:0006561)3.48907851
23intestinal cholesterol absorption (GO:0030299)3.47527496
24cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.45977943
25endothelium development (GO:0003158)3.40944218
26protein retention in ER lumen (GO:0006621)3.39384376
27negative regulation of keratinocyte proliferation (GO:0010839)3.38197805
28cell-substrate junction assembly (GO:0007044)3.38187110
29angiotensin maturation (GO:0002003)3.36799917
30proline metabolic process (GO:0006560)3.35281167
31cysteine metabolic process (GO:0006534)3.32416500
32peptidyl-glutamic acid carboxylation (GO:0017187)3.31500190
33protein carboxylation (GO:0018214)3.31500190
34glyoxylate metabolic process (GO:0046487)3.30565650
35maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.27829026
36positive regulation of p38MAPK cascade (GO:1900745)3.27152050
37transcytosis (GO:0045056)3.24152012
38regulation of cholesterol homeostasis (GO:2000188)3.22733383
39plasma lipoprotein particle assembly (GO:0034377)3.21054804
40carnitine shuttle (GO:0006853)3.18362960
41regulation of p38MAPK cascade (GO:1900744)3.18067836
42L-phenylalanine metabolic process (GO:0006558)3.16484129
43erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.16484129
44fatty acid transmembrane transport (GO:1902001)3.14700104
45basement membrane organization (GO:0071711)3.13343338
46aspartate family amino acid catabolic process (GO:0009068)3.09195790
47branching involved in salivary gland morphogenesis (GO:0060445)3.07613523
48response to mercury ion (GO:0046689)3.06016683
49drug transmembrane transport (GO:0006855)3.04358444
50fatty acid beta-oxidation (GO:0006635)3.03296448
51amino-acid betaine metabolic process (GO:0006577)3.01996421
52amino-acid betaine transport (GO:0015838)3.00290003
53carnitine transport (GO:0015879)3.00290003
542-oxoglutarate metabolic process (GO:0006103)3.00235595
55urea cycle (GO:0000050)2.99717198
56regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.97900838
57endothelial cell chemotaxis (GO:0035767)2.97424969
58L-phenylalanine catabolic process (GO:0006559)2.97001094
59erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.97001094
60NADH metabolic process (GO:0006734)2.94203218
61ventricular cardiac muscle cell action potential (GO:0086005)2.94112294
62endothelial cell morphogenesis (GO:0001886)2.93297652
63vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.93242510
64regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.92569372
65endocrine process (GO:0050886)2.92569372
66regulation of systemic arterial blood pressure by hormone (GO:0001990)2.92569372
67glomerulus development (GO:0032835)2.91481124
68protein-lipid complex assembly (GO:0065005)2.91472964
69sulfur amino acid catabolic process (GO:0000098)2.89203446
70renal absorption (GO:0070293)2.88921205
71glutamine family amino acid biosynthetic process (GO:0009084)2.88660782
72GDP-mannose metabolic process (GO:0019673)2.88375549
73quaternary ammonium group transport (GO:0015697)2.87993425
74regulation of guanylate cyclase activity (GO:0031282)2.86146701
75venous blood vessel morphogenesis (GO:0048845)2.85715695
76sarcomere organization (GO:0045214)2.85680664
77lung vasculature development (GO:0060426)2.85276981
78renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.84509001
79COPI coating of Golgi vesicle (GO:0048205)2.84123756
80Golgi transport vesicle coating (GO:0048200)2.84123756
81plasma membrane repair (GO:0001778)2.83818813
82regulation of endothelial cell chemotaxis (GO:2001026)2.83215262
83homocysteine metabolic process (GO:0050667)2.83040858
84urea metabolic process (GO:0019627)2.82798712
85carnitine metabolic process (GO:0009437)2.82299238
86fatty acid oxidation (GO:0019395)2.81848349
87lipoprotein metabolic process (GO:0042157)2.81834312
88retina vasculature morphogenesis in camera-type eye (GO:0061299)2.81520013
89negative regulation of fatty acid transport (GO:2000192)2.80963479
90adherens junction assembly (GO:0034333)2.80073999
91diacylglycerol metabolic process (GO:0046339)2.79446956
92negative regulation of chondrocyte differentiation (GO:0032331)2.78803075
93urate metabolic process (GO:0046415)2.78444397
94branching involved in mammary gland duct morphogenesis (GO:0060444)2.78266661
95drug catabolic process (GO:0042737)2.75531093
96regulation of cholesterol biosynthetic process (GO:0045540)2.75210556
97phosphate ion transport (GO:0006817)2.75000122
98actin filament depolymerization (GO:0030042)2.74858459
99lipid oxidation (GO:0034440)2.74053295
100activation of Rac GTPase activity (GO:0032863)2.73687766
101fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.73386216
102regulation of apoptotic process involved in morphogenesis (GO:1902337)2.72539444
103cell adhesion mediated by integrin (GO:0033627)2.72508391
104carnitine transmembrane transport (GO:1902603)2.72401463
105positive regulation of pseudopodium assembly (GO:0031274)2.72260475
106high-density lipoprotein particle remodeling (GO:0034375)2.71647286
107tricarboxylic acid metabolic process (GO:0072350)2.70636862
108regulation of systemic arterial blood pressure (GO:0003073)2.69301382
109valine metabolic process (GO:0006573)2.69250707
110metanephric epithelium development (GO:0072207)2.69075123
111chemical homeostasis within a tissue (GO:0048875)2.68911140
112regulation of cholesterol esterification (GO:0010872)2.68121996
113coronary vasculature morphogenesis (GO:0060977)2.66676366
114cytoskeletal anchoring at plasma membrane (GO:0007016)2.66640244
115regulation of plasminogen activation (GO:0010755)2.66227335
116positive regulation of fatty acid beta-oxidation (GO:0032000)2.65475538
117regulation of fibrinolysis (GO:0051917)2.65233353
118plasma lipoprotein particle remodeling (GO:0034369)2.65055991
119protein-lipid complex remodeling (GO:0034368)2.65055991
120macromolecular complex remodeling (GO:0034367)2.65055991
121gap junction assembly (GO:0016264)2.64899621
122phosphate ion transmembrane transport (GO:0035435)2.64865045
123renal system process involved in regulation of blood volume (GO:0001977)2.64686199
124cell-cell junction maintenance (GO:0045217)2.64662298
125glomerular filtration (GO:0003094)2.64303406
126regulation of metalloenzyme activity (GO:0048552)2.63498102
127regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.61702443
1284-hydroxyproline metabolic process (GO:0019471)2.60974449
129response to hepatocyte growth factor (GO:0035728)2.60588897
130cellular response to hepatocyte growth factor stimulus (GO:0035729)2.60588897
131ethanol oxidation (GO:0006069)2.60231313
132regulation of glomerular filtration (GO:0003093)2.59345292
133cellular ketone body metabolic process (GO:0046950)2.59155286
134regulation of cardioblast differentiation (GO:0051890)2.59022622
135cell-substrate adherens junction assembly (GO:0007045)2.58369069
136focal adhesion assembly (GO:0048041)2.58369069
137wound healing, spreading of epidermal cells (GO:0035313)2.58250690
138metanephric nephron epithelium development (GO:0072243)2.57539685
139acetyl-CoA metabolic process (GO:0006084)2.57288089
140hippo signaling (GO:0035329)2.57106153
141serine family amino acid catabolic process (GO:0009071)2.56187972
142plasma lipoprotein particle organization (GO:0071827)2.55921739
143short-chain fatty acid metabolic process (GO:0046459)2.55297997
144positive regulation of Cdc42 GTPase activity (GO:0043089)2.54901746
145atrioventricular valve morphogenesis (GO:0003181)2.53548021
146fatty acid catabolic process (GO:0009062)2.53233776
147protein localization to endosome (GO:0036010)2.52755672
148nucleotide-sugar biosynthetic process (GO:0009226)2.51925650
149lung epithelium development (GO:0060428)2.51273890
150patterning of blood vessels (GO:0001569)2.50620635
151regulation of extracellular matrix disassembly (GO:0010715)2.50484638
152regulation of endothelial cell differentiation (GO:0045601)2.50438874
153negative regulation of fibrinolysis (GO:0051918)2.49537867
154peptide catabolic process (GO:0043171)2.49356388
155exogenous drug catabolic process (GO:0042738)2.48750300
156regulation of tight junction assembly (GO:2000810)2.48660083
157planar cell polarity pathway involved in neural tube closure (GO:0090179)2.48553654
158peptidyl-proline hydroxylation (GO:0019511)2.47976112
159establishment of apical/basal cell polarity (GO:0035089)2.47623517
160regulation of cholesterol metabolic process (GO:0090181)2.47096954
161regulation of pseudopodium assembly (GO:0031272)2.46068897
162low-density lipoprotein particle remodeling (GO:0034374)2.44938836
163keratinocyte proliferation (GO:0043616)2.44689585
164chondrocyte proliferation (GO:0035988)2.44180557
165protein-lipid complex subunit organization (GO:0071825)2.43733648
166triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.43174068
167sexual reproduction (GO:0019953)2.41879747
168cholesterol homeostasis (GO:0042632)2.40554619
169regulation of water loss via skin (GO:0033561)2.40159824
170cellular zinc ion homeostasis (GO:0006882)2.39103267
171regulation of transforming growth factor beta1 production (GO:0032908)2.38945435
172reverse cholesterol transport (GO:0043691)2.38102562
173apoptotic process involved in morphogenesis (GO:0060561)2.37229261
174positive regulation of osteoblast proliferation (GO:0033690)2.37130644

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.51975684
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.88511319
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.83449841
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.45426676
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.29420244
6CLOCK_20551151_ChIP-Seq_293T_Human3.14489691
7* RARG_19884340_ChIP-ChIP_MEFs_Mouse3.12344117
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.03960279
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.84928952
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.73394560
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.70232007
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.57854399
13ZNF263_19887448_ChIP-Seq_K562_Human2.50029527
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.30206791
15FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.25393888
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.23753640
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.18841680
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17719069
19FOXO3_23340844_ChIP-Seq_DLD1_Human1.80789765
20RACK7_27058665_Chip-Seq_MCF-7_Human1.80682542
21KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.79681237
22* ELK3_25401928_ChIP-Seq_HUVEC_Human1.74235707
23HIF1A_21447827_ChIP-Seq_MCF-7_Human1.72175667
24TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.71375559
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.70772211
26NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.69584443
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.68549918
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.68165558
29GATA2_21666600_ChIP-Seq_HMVEC_Human1.61446963
30SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.59973464
31TBX20_22328084_ChIP-Seq_HEART_Mouse1.59715600
32TBX20_22080862_ChIP-Seq_HEART_Mouse1.59715600
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59663334
34SOX2_27498859_Chip-Seq_STOMACH_Mouse1.58174168
35TP53_22127205_ChIP-Seq_IMR90_Human1.56637004
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56330065
37* LXR_22292898_ChIP-Seq_THP-1_Human1.56095027
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55358744
39SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.55166964
40EP300_21415370_ChIP-Seq_HL-1_Mouse1.54076958
41* CDX2_20551321_ChIP-Seq_CACO-2_Human1.53493829
42ATF3_27146783_Chip-Seq_COLON_Human1.49962221
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.49383149
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47529316
45* TET1_21451524_ChIP-Seq_MESCs_Mouse1.47317651
46KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46646987
47CTCF_27219007_Chip-Seq_Bcells_Human1.43758174
48UBF1/2_26484160_Chip-Seq_HMECs_Human1.38906732
49* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.38882069
50SOX9_24532713_ChIP-Seq_HFSC_Mouse1.38622315
51GATA4_25053715_ChIP-Seq_YYC3_Human1.37828132
52P68_20966046_ChIP-Seq_HELA_Human1.36933999
53TCF3_18692474_ChIP-Seq_MEFs_Mouse1.35730252
54NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.35678359
55KLF5_25053715_ChIP-Seq_YYC3_Human1.33148028
56RUNX1_27514584_Chip-Seq_MCF-7_Human1.32041559
57HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.31746624
58P63_26484246_Chip-Seq_KERATINOCYTES_Human1.31359786
59SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.29191906
60SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.29191906
61* SMC4_20622854_ChIP-Seq_HELA_Human1.28227023
62FOXA2_19822575_ChIP-Seq_HepG2_Human1.26188508
63GATA6_25053715_ChIP-Seq_YYC3_Human1.25579191
64* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24736792
65ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.23726662
66SOX2_20726797_ChIP-Seq_SW620_Human1.23432421
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22469759
68SALL4_18804426_ChIP-ChIP_XEN_Mouse1.20423737
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.20145693
70SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18895371
71ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18390151
72SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.17985543
73ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16330530
74ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16319602
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15824542
76EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.15135274
77BCOR_27268052_Chip-Seq_Bcells_Human1.14894727
78MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14857696
79* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14533537
80P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14475485
81CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14460154
82KDM2B_26808549_Chip-Seq_K562_Human1.13607741
83TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.13229297
84RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11886831
85* HNF4A_19822575_ChIP-Seq_HepG2_Human1.10647683
86* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08974132
87KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.07953799
88KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.07953799
89KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.07953799
90SA1_27219007_Chip-Seq_ERYTHROID_Human1.07480333
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06345284
92TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06222812
93* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05938424
94* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05620683
95PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.04752575
96RARA_24833708_ChIP-Seq_LIVER_Mouse1.04682186
97UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04507641
98* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04472870
99* TP63_22573176_ChIP-Seq_HFKS_Human1.04430173
100ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04392703
101KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04098419
102* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03324471
103PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03167411
104ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02992593
105KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02646742
106CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01990576
107DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01846678
108HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01672630
109KDM2B_26808549_Chip-Seq_DND41_Human1.01027250
110E2F1_20622854_ChIP-Seq_HELA_Human0.99938329
111NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99795936
112PHF8_20622854_ChIP-Seq_HELA_Human0.98579067
113EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97749605
114ERG_21242973_ChIP-ChIP_JURKAT_Human0.97282262
115SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96575576
116SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95879610
117* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95670632
118AR_21909140_ChIP-Seq_LNCAP_Human0.95658060
119GATA1_19941826_ChIP-Seq_K562_Human0.94887083
120JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.94570312
121TET1_21490601_ChIP-Seq_MESCs_Mouse0.94467104
122CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94328008
123CREB1_26743006_Chip-Seq_LNCaP_Human0.94250087
124CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94243753
125CJUN_26792858_Chip-Seq_BT549_Human0.93761898
126TCF4_18268006_ChIP-ChIP_LS174T_Human0.90553714
127* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.90191222
128KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89958646
129CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89665893
130* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89647416
131GATA3_24758297_ChIP-Seq_MCF-7_Human0.88999694

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis3.53199778
2MP0010368_abnormal_lymphatic_system3.51725420
3MP0002139_abnormal_hepatobiliary_system3.42587530
4MP0004272_abnormal_basement_membrane3.21554405
5MP0005167_abnormal_blood-brain_barrier2.89314637
6MP0002138_abnormal_hepatobiliary_system2.79220092
7MP0003705_abnormal_hypodermis_morpholog2.78533232
8MP0004084_abnormal_cardiac_muscle2.75897403
9MP0000566_synostosis2.69624206
10MP0001879_abnormal_lymphatic_vessel2.67062333
11MP0000678_abnormal_parathyroid_gland2.63767615
12MP0010234_abnormal_vibrissa_follicle2.62131205
13MP0005409_darkened_coat_color2.61105762
14MP0005085_abnormal_gallbladder_physiolo2.49804263
15MP0003252_abnormal_bile_duct2.43772636
16MP0003566_abnormal_cell_adhesion2.25178366
17MP0005365_abnormal_bile_salt2.22089142
18MP0002796_impaired_skin_barrier2.11012629
19MP0000537_abnormal_urethra_morphology2.10576546
20MP0009780_abnormal_chondrocyte_physiolo1.99195537
21MP0005332_abnormal_amino_acid1.95830650
22MP0002837_dystrophic_cardiac_calcinosis1.95694085
23MP0000762_abnormal_tongue_morphology1.92158412
24MP0009643_abnormal_urine_homeostasis1.78573778
25MP0008875_abnormal_xenobiotic_pharmacok1.77710296
26MP0004036_abnormal_muscle_relaxation1.67867069
27MP0005670_abnormal_white_adipose1.67551390
28MP0006138_congestive_heart_failure1.64086672
29MP0002089_abnormal_postnatal_growth/wei1.61770383
30MP0004019_abnormal_vitamin_homeostasis1.61204795
31MP0005410_abnormal_fertilization1.59563106
32MP0005275_abnormal_skin_tensile1.56593642
33MP0001666_abnormal_nutrient_absorption1.55915145
34MP0005666_abnormal_adipose_tissue1.54907390
35MP0005257_abnormal_intraocular_pressure1.54199330
36MP0004858_abnormal_nervous_system1.52130318
37MP0008438_abnormal_cutaneous_collagen1.51980628
38MP0005623_abnormal_meninges_morphology1.50379603
39MP0003950_abnormal_plasma_membrane1.47737147
40MP0005083_abnormal_biliary_tract1.41415256
41MP0010329_abnormal_lipoprotein_level1.41181707
42MP0003300_gastrointestinal_ulcer1.40796166
43MP0002254_reproductive_system_inflammat1.40679868
44MP0005501_abnormal_skin_physiology1.37521548
45MP0004185_abnormal_adipocyte_glucose1.37014304
46MP0003941_abnormal_skin_development1.35466700
47MP0010630_abnormal_cardiac_muscle1.34452165
48MP0004264_abnormal_extraembryonic_tissu1.33921570
49MP0000751_myopathy1.30825052
50MP0005330_cardiomyopathy1.29515708
51MP0003191_abnormal_cellular_cholesterol1.29026895
52MP0002136_abnormal_kidney_physiology1.28229783
53MP0004215_abnormal_myocardial_fiber1.27142648
54MP0008775_abnormal_heart_ventricle1.25586052
55MP0001544_abnormal_cardiovascular_syste1.25202101
56MP0005385_cardiovascular_system_phenoty1.25202101
57MP0003828_pulmonary_edema1.25008330
58MP0001348_abnormal_lacrimal_gland1.24399532
59MP0004130_abnormal_muscle_cell1.22400648
60MP0002972_abnormal_cardiac_muscle1.21052639
61MP0003315_abnormal_perineum_morphology1.20835381
62MP0005375_adipose_tissue_phenotype1.20791869
63MP0004087_abnormal_muscle_fiber1.19340652
64MP0005076_abnormal_cell_differentiation1.17204336
65MP0001756_abnormal_urination1.16688016
66MP0003806_abnormal_nucleotide_metabolis1.16337877
67MP0004782_abnormal_surfactant_physiolog1.16282543
68MP0000013_abnormal_adipose_tissue1.14417768
69MP0001849_ear_inflammation1.12644804
70MP0005023_abnormal_wound_healing1.12514718
71MP0010030_abnormal_orbit_morphology1.10621581
72MP0001958_emphysema1.10246099
73MP0005165_increased_susceptibility_to1.10087513
74MP0003868_abnormal_feces_composition1.07079679
75MP0002060_abnormal_skin_morphology1.05998366
76MP0002249_abnormal_larynx_morphology1.04015111
77MP0000750_abnormal_muscle_regeneration1.02612324
78MP0010352_gastrointestinal_tract_polyps1.02471912
79MP0005319_abnormal_enzyme/_coenzyme1.02095144
80MP0008004_abnormal_stomach_pH1.01431450
81MP0002896_abnormal_bone_mineralization1.00807610
82MP0006054_spinal_hemorrhage1.00785797
83MP0003091_abnormal_cell_migration1.00744705
84MP0005620_abnormal_muscle_contractility0.99340761
85MP0003453_abnormal_keratinocyte_physiol0.98510571
86MP0008961_abnormal_basal_metabolism0.98392574
87MP0005084_abnormal_gallbladder_morpholo0.97671381
88MP0002128_abnormal_blood_circulation0.97261435
89MP0010678_abnormal_skin_adnexa0.97156348
90MP0002118_abnormal_lipid_homeostasis0.94850379
91MP0000003_abnormal_adipose_tissue0.93889373
92MP0000609_abnormal_liver_physiology0.91884722
93MP0009840_abnormal_foam_cell0.91296210
94MP0000230_abnormal_systemic_arterial0.91248771
95MP0001216_abnormal_epidermal_layer0.91140499
96MP0004484_altered_response_of0.91057023
97MP0002928_abnormal_bile_duct0.90935593
98MP0003279_aneurysm0.90852666
99MP0004133_heterotaxia0.90341051
100MP0010771_integument_phenotype0.89022787
101MP0000538_abnormal_urinary_bladder0.89003137
102MP0009053_abnormal_anal_canal0.88211621
103MP0000767_abnormal_smooth_muscle0.88185475
104MP0002925_abnormal_cardiovascular_devel0.87399875
105MP0002269_muscular_atrophy0.86661809
106MP0000467_abnormal_esophagus_morphology0.86658849
107MP0003183_abnormal_peptide_metabolism0.85481786
108MP0000477_abnormal_intestine_morphology0.84776216
109MP0004043_abnormal_pH_regulation0.83985833
110MP0000749_muscle_degeneration0.83256602
111MP0000462_abnormal_digestive_system0.83233296
112MP0001614_abnormal_blood_vessel0.82656971
113MP0002135_abnormal_kidney_morphology0.81339682
114MP0008260_abnormal_autophagy0.80915197
115MP0001765_abnormal_ion_homeostasis0.80123308
116MP0003283_abnormal_digestive_organ0.79959515
117MP0002877_abnormal_melanocyte_morpholog0.79470250
118MP0002234_abnormal_pharynx_morphology0.79048513
119MP0000747_muscle_weakness0.78998649
120MP0003718_maternal_effect0.78985439
121MP0002098_abnormal_vibrissa_morphology0.77571997
122MP0000266_abnormal_heart_morphology0.77545650
123MP0000579_abnormal_nail_morphology0.76360600
124MP0000534_abnormal_ureter_morphology0.75810676
125MP0003115_abnormal_respiratory_system0.75200024
126MP0002295_abnormal_pulmonary_circulatio0.75185232
127MP0005451_abnormal_body_composition0.74491406
128MP0001664_abnormal_digestion0.68768034
129MP0009379_abnormal_foot_pigmentation0.68530300
130MP0003755_abnormal_palate_morphology0.68332053
131MP0002086_abnormal_extraembryonic_tissu0.68094272
132MP0000733_abnormal_muscle_development0.67112219
133MP0002697_abnormal_eye_size0.65336397
134MP0001730_embryonic_growth_arrest0.64785440
135MP0009931_abnormal_skin_appearance0.64005396
136MP0001661_extended_life_span0.63981247
137MP0000377_abnormal_hair_follicle0.62273095
138MP0004233_abnormal_muscle_weight0.62239888
139MP0003119_abnormal_digestive_system0.59664896
140MP0003879_abnormal_hair_cell0.58062167
141MP0003385_abnormal_body_wall0.56350320

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)5.26454084
2Focal segmental glomerulosclerosis (HP:0000097)4.49678127
3Mesangial abnormality (HP:0001966)4.35742277
4Gout (HP:0001997)3.91402507
5Glomerulosclerosis (HP:0000096)3.90260383
6Ventricular tachycardia (HP:0004756)3.78200543
7Esophageal varix (HP:0002040)3.68529757
8Deep venous thrombosis (HP:0002625)3.66994561
9Lymphangioma (HP:0100764)3.64240174
10Muscle fiber splitting (HP:0003555)3.46864718
11Increased connective tissue (HP:0009025)3.38352942
12Hyperglycinuria (HP:0003108)3.19593731
13Alopecia of scalp (HP:0002293)3.13086955
14Flat acetabular roof (HP:0003180)3.10872070
15Pterygium (HP:0001059)3.06461873
16Abnormality of glutamine family amino acid metabolism (HP:0010902)3.04296790
17Hyperactive renin-angiotensin system (HP:0000841)3.03439208
18Sudden death (HP:0001699)3.03104363
19Hyporeflexia of lower limbs (HP:0002600)2.99112115
20Milia (HP:0001056)2.93398258
21Premature rupture of membranes (HP:0001788)2.91011754
22Protrusio acetabuli (HP:0003179)2.88874431
23Abnormality of monocarboxylic acid metabolism (HP:0010996)2.88092349
24Polycythemia (HP:0001901)2.84735774
25Fragile skin (HP:0001030)2.79606412
26Broad face (HP:0000283)2.76627364
27Xanthomatosis (HP:0000991)2.74667479
28Intrahepatic cholestasis (HP:0001406)2.69007219
29Hyperammonemia (HP:0001987)2.68827296
30Hypokalemic alkalosis (HP:0001949)2.67690715
31Hypobetalipoproteinemia (HP:0003563)2.67525714
32Onycholysis (HP:0001806)2.65612767
33Abnormality of glycine metabolism (HP:0010895)2.64100237
34Abnormality of serine family amino acid metabolism (HP:0010894)2.64100237
35Ketoacidosis (HP:0001993)2.63665937
36Hyperuricemia (HP:0002149)2.63471538
37Increased purine levels (HP:0004368)2.63471538
38Abnormality of carpal bone ossification (HP:0006257)2.63038074
39Thick nail (HP:0001805)2.61011424
40Ketosis (HP:0001946)2.59141892
41Distal lower limb muscle weakness (HP:0009053)2.58517297
42Increased circulating renin level (HP:0000848)2.58306619
43Abnormality of purine metabolism (HP:0004352)2.52416542
44Cervical subluxation (HP:0003308)2.52355775
45Ileus (HP:0002595)2.50298748
46Neonatal death (HP:0003811)2.49304533
47Vascular calcification (HP:0004934)2.47436871
48Abnormality of chloride homeostasis (HP:0011422)2.47176788
49Abnormality of proline metabolism (HP:0010907)2.46176483
50Hydroxyprolinuria (HP:0003080)2.46176483
51Atrophic scars (HP:0001075)2.45985175
52Nephritis (HP:0000123)2.44827656
53Abnormal ossification of hand bones (HP:0005921)2.42943826
54Facial shape deformation (HP:0011334)2.42855740
55Potter facies (HP:0002009)2.42855740
56Hypercholesterolemia (HP:0003124)2.42242739
57Myoglobinuria (HP:0002913)2.38663418
58Natal tooth (HP:0000695)2.37285447
59Pili torti (HP:0003777)2.36149466
60Cardiovascular calcification (HP:0011915)2.35737302
61Hypolipoproteinemia (HP:0010981)2.35605559
62Visceral angiomatosis (HP:0100761)2.35421653
63Thin bony cortex (HP:0002753)2.34940780
64Distal lower limb amyotrophy (HP:0008944)2.33937902
65Difficulty running (HP:0009046)2.33453601
66Hypoglycemic coma (HP:0001325)2.32628992
67Palmoplantar hyperkeratosis (HP:0000972)2.32554758
68Difficulty climbing stairs (HP:0003551)2.32426810
69Fragile nails (HP:0001808)2.32361964
70Abnormality of fatty-acid metabolism (HP:0004359)2.31129544
71Broad metatarsal (HP:0001783)2.30271733
72Short nail (HP:0001799)2.28252371
73Abnormal albumin level (HP:0012116)2.27491845
74Hypoalbuminemia (HP:0003073)2.27491845
75Upper limb amyotrophy (HP:0009129)2.27154495
76Distal upper limb amyotrophy (HP:0007149)2.27154495
77Prolonged partial thromboplastin time (HP:0003645)2.24034994
78Popliteal pterygium (HP:0009756)2.23459641
79Abnormal hair laboratory examination (HP:0003328)2.23174106
80Trismus (HP:0000211)2.18291072
81Malnutrition (HP:0004395)2.14394266
82Hemangiomatosis (HP:0007461)2.14300686
83Ulnar bowing (HP:0003031)2.14278621
84Palpitations (HP:0001962)2.13824796
85Palmar hyperkeratosis (HP:0010765)2.13002170
86Stage 5 chronic kidney disease (HP:0003774)2.12132222
87Hypoplasia of dental enamel (HP:0006297)2.11001343
88Ankyloglossia (HP:0010296)2.10681377
89Syncope (HP:0001279)2.10658815
90Exercise-induced muscle cramps (HP:0003710)2.09568982
91Abdominal distention (HP:0003270)2.09535971
92Abnormal hand bone ossification (HP:0010660)2.08208672
93Cerebral aneurysm (HP:0004944)2.07862120
94Abnormality of aromatic amino acid family metabolism (HP:0004338)2.07267870
95Metaphyseal cupping (HP:0003021)2.04730812
96Mildly elevated creatine phosphokinase (HP:0008180)2.04143800
97Abnormality of nucleobase metabolism (HP:0010932)2.02818420
98Proximal tubulopathy (HP:0000114)2.01642727
99Selective tooth agenesis (HP:0001592)2.00414335
100Joint hemorrhage (HP:0005261)1.99478812
101Aneurysm (HP:0002617)1.99367516
102Late onset (HP:0003584)1.99314241
103Rectal prolapse (HP:0002035)1.98669621
104Abnormality of nail color (HP:0100643)1.98374961
105Lipoatrophy (HP:0100578)1.98313170
106Abnormality of the Achilles tendon (HP:0005109)1.97593767
107Bronchomalacia (HP:0002780)1.95570537
108Abnormality of the nasal septum (HP:0000419)1.93985130
109Menorrhagia (HP:0000132)1.92749843
110Insulin resistance (HP:0000855)1.92528634
111Abnormality of complement system (HP:0005339)1.92324192
112Tubular atrophy (HP:0000092)1.90741134
113Plantar hyperkeratosis (HP:0007556)1.89778260
114Back pain (HP:0003418)1.89094665
115Widely patent fontanelles and sutures (HP:0004492)1.88980958
116Ventricular fibrillation (HP:0001663)1.87898453
117Dicarboxylic aciduria (HP:0003215)1.87045556
118Abnormality of dicarboxylic acid metabolism (HP:0010995)1.87045556
119Vertebral clefting (HP:0008428)1.86772750
120Hyperacusis (HP:0010780)1.86371200
121Woolly hair (HP:0002224)1.86210903
122Stridor (HP:0010307)1.85626914
123Chondrocalcinosis (HP:0000934)1.85162819
124Neonatal short-limb short stature (HP:0008921)1.85011846
125Acanthosis nigricans (HP:0000956)1.84823462
126Alkalosis (HP:0001948)1.84315587
127Ventricular arrhythmia (HP:0004308)1.83908103
128Wide cranial sutures (HP:0010537)1.83469367
129Hematochezia (HP:0002573)1.82720847
130Abnormality of renal excretion (HP:0011036)1.82653331
131Rhabdomyolysis (HP:0003201)1.82092550
132Neonatal onset (HP:0003623)1.81504061
133Ridged nail (HP:0001807)1.80817587
134Tubulointerstitial fibrosis (HP:0005576)1.80469537
135Atrial fibrillation (HP:0005110)1.80303483
136Fat malabsorption (HP:0002630)1.79964641
137Advanced eruption of teeth (HP:0006288)1.79895429
138Coxa vara (HP:0002812)1.79560697
139Hypoalphalipoproteinemia (HP:0003233)1.79517049
140Exercise-induced myalgia (HP:0003738)1.79106175
141Nail dystrophy (HP:0008404)1.77927537
142Hyperlipoproteinemia (HP:0010980)1.77880970
143Pigmentary retinal degeneration (HP:0001146)1.77490587
144Renal salt wasting (HP:0000127)1.77020798
145Dilated cardiomyopathy (HP:0001644)1.76303367
146Hemorrhage of the eye (HP:0011885)1.75783608
147Hyperglycinemia (HP:0002154)1.75651181
148Mitral stenosis (HP:0001718)1.74930378
149Abnormality of renin-angiotensin system (HP:0000847)1.73886572
150Abnormality of sulfur amino acid metabolism (HP:0004339)1.72735543
151Abnormality of oral frenula (HP:0000190)1.72124408
152Shallow orbits (HP:0000586)1.72103882
153Abnormal urine output (HP:0012590)1.71975268
154Abnormal blistering of the skin (HP:0008066)1.69303391
155Achilles tendon contracture (HP:0001771)1.68933178
156Hyperkalemia (HP:0002153)1.67593694
157Subcapsular cataract (HP:0000523)1.67341055
158Abnormality of the distal phalanges of the toes (HP:0010182)1.66678686
159Abnormal vertebral ossification (HP:0100569)1.64884390
160Conjugated hyperbilirubinemia (HP:0002908)1.64531698
161Spinal rigidity (HP:0003306)1.64310581
162Complement deficiency (HP:0004431)1.64067507
163Progressive sensorineural hearing impairment (HP:0000408)1.63730708
164Myocardial infarction (HP:0001658)1.63497663

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.76270593
2EPHA23.94740104
3KDR3.85910774
4WNK43.20191946
5TTN2.88471761
6TRIB32.87459039
7EPHB22.66028622
8IRAK32.62277530
9ERN12.45240028
10PKN22.38223576
11BCKDK2.38210305
12TGFBR22.33236961
13RIPK12.29694941
14PTK62.15849140
15PAK42.09177578
16FER2.00194909
17TESK11.99571787
18MAP3K31.83647139
19SMG11.79980756
20PTK21.77790466
21LATS11.76064373
22EPHB11.75963404
23TGFBR11.73228943
24FGFR41.73149549
25MYLK1.64836822
26LMTK21.53596107
27OXSR11.43646115
28MAP2K31.38547469
29MST1R1.36171363
30STK391.32511902
31MET1.30430111
32STK38L1.28460062
33MAP2K21.28455990
34PDGFRA1.22047443
35SIK11.21614368
36CDK121.20860659
37INSRR1.18930243
38NME21.18804830
39LRRK21.18178206
40PDK41.11441087
41PDK31.11441087
42PDK21.09522847
43NEK11.08529700
44RPS6KB21.07200668
45DMPK1.06595269
46MAPKAPK31.04980682
47LATS21.04571838
48PRKG20.99967703
49MAP3K70.97490769
50MAP3K110.95678038
51TRPM70.93434243
52PTK2B0.93256374
53NTRK10.89864630
54STK100.89003152
55MAP3K100.87733271
56MAP2K10.85956885
57MAP3K20.81279574
58MTOR0.80836380
59PAK30.80322604
60NME10.78444324
61CDK80.78363874
62BMX0.76978186
63ARAF0.70679660
64FGFR30.70010699
65ERBB40.69678509
66CDC42BPA0.69157719
67CDK70.69144583
68FGFR10.69020534
69MAP3K90.66661870
70PRKD10.66532618
71GSK3A0.65614304
72MAP3K10.65062911
73ACVR1B0.63159029
74GRK10.62918253
75CAMK1D0.62856277
76PHKG10.62559696
77PHKG20.62559696
78RPS6KA20.61835057
79MST40.61381634
80ROCK10.59739752
81WNK30.57548982
82PIM20.56879351
83ABL20.51648952
84PBK0.51396554
85PAK20.51237081
86PRKAA20.50259289
87MAP3K120.49831247
88FGFR20.48851309
89MAP3K60.48252198
90STK380.46644920
91CSK0.45641679
92MAPK150.45570083
93ICK0.44246221
94MAP3K80.42014516
95AKT20.41795666
96KSR20.40989927
97NEK20.40113763
98STK240.38207999
99LIMK10.37450994
100ERBB20.37402199
101MELK0.37338333
102CAMK1G0.36699526
103MUSK0.36411845
104STK30.35925239
105PDGFRB0.35401299
106ILK0.35095796
107PRKCI0.33929028
108CDK60.33853088
109MAP2K60.33601288
110FLT30.33015697
111MAPK120.31678255
112SRC0.31631059
113PRKD30.31572241
114BRAF0.30403659
115BUB10.30144933
116PDPK10.29676974
117DYRK1B0.29628071
118EEF2K0.28969230
119DDR20.28636915
120PRKD20.27770961
121TAOK10.27323593
122PRKAA10.25514282
123JAK20.24720485
124RET0.24618107
125EGFR0.24225657
126MAPK110.24155807
127PRKCH0.23633016
128TYRO30.23218157
129CAMK2D0.23189633
130FRK0.22970429
131MAPKAPK20.22500280

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.08910553
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.79198257
3Fatty acid degradation_Homo sapiens_hsa000712.75014173
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.60521126
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.49663999
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.40356547
7Propanoate metabolism_Homo sapiens_hsa006402.34807975
8Nitrogen metabolism_Homo sapiens_hsa009102.30143613
9Arginine biosynthesis_Homo sapiens_hsa002202.29434130
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.17616716
11Galactose metabolism_Homo sapiens_hsa000522.12962435
12PPAR signaling pathway_Homo sapiens_hsa033201.99136984
13Tryptophan metabolism_Homo sapiens_hsa003801.96326045
14Butanoate metabolism_Homo sapiens_hsa006501.94265623
15ECM-receptor interaction_Homo sapiens_hsa045121.90039990
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.87438057
17Fatty acid metabolism_Homo sapiens_hsa012121.87162731
18Bile secretion_Homo sapiens_hsa049761.72209325
19Pyruvate metabolism_Homo sapiens_hsa006201.70712726
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.70432407
21Carbon metabolism_Homo sapiens_hsa012001.61075997
22Vitamin B6 metabolism_Homo sapiens_hsa007501.57719946
23Fat digestion and absorption_Homo sapiens_hsa049751.57284909
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.54250411
25Fatty acid biosynthesis_Homo sapiens_hsa000611.53701802
26Complement and coagulation cascades_Homo sapiens_hsa046101.50073641
27beta-Alanine metabolism_Homo sapiens_hsa004101.46502910
28Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.45957939
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.45927626
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.42061231
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38659726
32Peroxisome_Homo sapiens_hsa041461.38094515
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.37860275
34Protein digestion and absorption_Homo sapiens_hsa049741.37786497
35Adherens junction_Homo sapiens_hsa045201.34187927
36Focal adhesion_Homo sapiens_hsa045101.32454644
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25654558
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.22617830
39Mineral absorption_Homo sapiens_hsa049781.22460554
40Lysine degradation_Homo sapiens_hsa003101.22442065
41Tight junction_Homo sapiens_hsa045301.21181290
42Caffeine metabolism_Homo sapiens_hsa002321.21089689
43Phenylalanine metabolism_Homo sapiens_hsa003601.18980307
44Small cell lung cancer_Homo sapiens_hsa052221.16971785
45Other glycan degradation_Homo sapiens_hsa005111.15511051
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13440183
47Dilated cardiomyopathy_Homo sapiens_hsa054141.11970561
48Biosynthesis of amino acids_Homo sapiens_hsa012301.11345267
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.11201788
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10228146
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.09936224
52Glycosaminoglycan degradation_Homo sapiens_hsa005311.09764544
53Amoebiasis_Homo sapiens_hsa051461.07480883
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05968455
55Histidine metabolism_Homo sapiens_hsa003401.05767669
56Glycerolipid metabolism_Homo sapiens_hsa005611.05293418
57Leukocyte transendothelial migration_Homo sapiens_hsa046701.05264382
58Starch and sucrose metabolism_Homo sapiens_hsa005001.02126334
59Arginine and proline metabolism_Homo sapiens_hsa003301.01775239
60Chemical carcinogenesis_Homo sapiens_hsa052041.01379114
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01331974
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00078030
63N-Glycan biosynthesis_Homo sapiens_hsa005100.99944467
64Bladder cancer_Homo sapiens_hsa052190.99044150
65Insulin resistance_Homo sapiens_hsa049310.89663156
66Vitamin digestion and absorption_Homo sapiens_hsa049770.88233468
67Selenocompound metabolism_Homo sapiens_hsa004500.85189523
68Hippo signaling pathway_Homo sapiens_hsa043900.83506504
69Sphingolipid metabolism_Homo sapiens_hsa006000.82827185
70Proteoglycans in cancer_Homo sapiens_hsa052050.81802832
71Glutathione metabolism_Homo sapiens_hsa004800.79273854
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.74330590
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.70855293
74Thyroid hormone synthesis_Homo sapiens_hsa049180.70284527
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70102548
76Basal cell carcinoma_Homo sapiens_hsa052170.68690068
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67664530
78Sulfur metabolism_Homo sapiens_hsa009200.66365635
79Retinol metabolism_Homo sapiens_hsa008300.66353274
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66048279
81Tyrosine metabolism_Homo sapiens_hsa003500.64834005
82Renin-angiotensin system_Homo sapiens_hsa046140.64027907
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63264468
84ABC transporters_Homo sapiens_hsa020100.60382072
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59939944
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.57663753
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.56313371
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55099176
89Arachidonic acid metabolism_Homo sapiens_hsa005900.54655914
90Folate biosynthesis_Homo sapiens_hsa007900.53631967
91Thyroid cancer_Homo sapiens_hsa052160.53327579
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.53096603
93Prion diseases_Homo sapiens_hsa050200.52624260
94Rap1 signaling pathway_Homo sapiens_hsa040150.52221992
95Fatty acid elongation_Homo sapiens_hsa000620.52158559
96Steroid biosynthesis_Homo sapiens_hsa001000.49389108
97Dorso-ventral axis formation_Homo sapiens_hsa043200.47361184
98Staphylococcus aureus infection_Homo sapiens_hsa051500.47358723
99AMPK signaling pathway_Homo sapiens_hsa041520.47083538
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46226747
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45791062
102Viral myocarditis_Homo sapiens_hsa054160.45657746
103VEGF signaling pathway_Homo sapiens_hsa043700.45444688
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43669601
105Fructose and mannose metabolism_Homo sapiens_hsa000510.43502573
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43478018
107Notch signaling pathway_Homo sapiens_hsa043300.42808450
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42707912
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41576167
110Glucagon signaling pathway_Homo sapiens_hsa049220.41321593
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40988202
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.40701224
113Pancreatic secretion_Homo sapiens_hsa049720.40622518
114Chronic myeloid leukemia_Homo sapiens_hsa052200.39835458
115Hedgehog signaling pathway_Homo sapiens_hsa043400.39323834
116TGF-beta signaling pathway_Homo sapiens_hsa043500.39276430
117Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37482108
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37285443
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.36901488
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35159357
121Pathways in cancer_Homo sapiens_hsa052000.34856746
122Metabolic pathways_Homo sapiens_hsa011000.34005726
123Insulin signaling pathway_Homo sapiens_hsa049100.33276551
124Sulfur relay system_Homo sapiens_hsa041220.33101029
125MicroRNAs in cancer_Homo sapiens_hsa052060.32683495
126Pentose phosphate pathway_Homo sapiens_hsa000300.32513637

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