CAPZA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an actin capping protein, one of the F-actin capping protein alpha subunit family. The encoded protein is predominantly localized to the neck region of ejaculated sperm, other immunohistochemical signals were found in the tail and postacrosomal regions. The encoded protein may also form heterodimers of alpha and beta subunits. This protein may be important in determining sperm architecture and male fertility. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.85153438
2axonemal dynein complex assembly (GO:0070286)9.80812248
3reproduction (GO:0000003)9.59308920
4* spermatid development (GO:0007286)9.45567479
5motile cilium assembly (GO:0044458)9.36885595
6cilium or flagellum-dependent cell motility (GO:0001539)9.16366658
7response to pheromone (GO:0019236)9.05116337
8regulation of cilium movement (GO:0003352)8.55436820
9cilium movement (GO:0003341)8.11960919
10single fertilization (GO:0007338)7.44744752
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.39779705
12sperm capacitation (GO:0048240)7.27053865
13rRNA methylation (GO:0031167)7.23941240
14negative regulation of inclusion body assembly (GO:0090084)7.06300893
15synaptonemal complex organization (GO:0070193)7.04737190
16male meiosis (GO:0007140)6.98366907
17synaptonemal complex assembly (GO:0007130)6.94930817
18piRNA metabolic process (GO:0034587)6.88037195
19organic cation transport (GO:0015695)6.76100862
20spermatogenesis (GO:0007283)6.74353606
21male gamete generation (GO:0048232)6.71823634
22phosphatidylethanolamine biosynthetic process (GO:0006646)6.52980333
23protein targeting to Golgi (GO:0000042)6.49636707
24microtubule depolymerization (GO:0007019)6.48444168
25fertilization (GO:0009566)6.30283398
26establishment of protein localization to Golgi (GO:0072600)6.23014205
27gamete generation (GO:0007276)6.17458114
28rRNA modification (GO:0000154)6.08941491
29retrograde transport, vesicle recycling within Golgi (GO:0000301)6.04043607
30phosphatidylethanolamine metabolic process (GO:0046337)6.02312890
31regulation of inclusion body assembly (GO:0090083)5.98027230
32cellular ketone body metabolic process (GO:0046950)5.86139942
33calcium ion-dependent exocytosis (GO:0017156)5.64639284
34spermatid nucleus differentiation (GO:0007289)5.38176073
35* cellular process involved in reproduction in multicellular organism (GO:0022412)5.30023393
36* germ cell development (GO:0007281)5.22620560
37centriole replication (GO:0007099)5.21765696
38cell recognition (GO:0008037)5.18516290
39ketone body metabolic process (GO:1902224)5.17363897
40ventricular system development (GO:0021591)5.16334937
41chromosome condensation (GO:0030261)5.12063437
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.11192880
43regulation of microtubule-based movement (GO:0060632)5.02978711
44glycerol ether metabolic process (GO:0006662)5.00098919
45positive regulation of Rab GTPase activity (GO:0032851)4.94743013
46regulation of Rab GTPase activity (GO:0032313)4.94743013
47multicellular organismal reproductive process (GO:0048609)4.86284680
48microtubule severing (GO:0051013)4.85244036
49DNA packaging (GO:0006323)4.84994237
50centriole assembly (GO:0098534)4.73873284
51chromosome organization involved in meiosis (GO:0070192)4.73245910
52male meiosis I (GO:0007141)4.69097405
53protein localization to Golgi apparatus (GO:0034067)4.66073057
54ether metabolic process (GO:0018904)4.63042274
55seminiferous tubule development (GO:0072520)4.59264633
56DNA methylation involved in gamete generation (GO:0043046)4.39935281
57regulation of transcription involved in cell fate commitment (GO:0060850)4.38718161
58left/right pattern formation (GO:0060972)4.26855156
59sexual reproduction (GO:0019953)4.26545209
60regulation of centriole replication (GO:0046599)4.19927754
61coenzyme catabolic process (GO:0009109)4.17368293
62single strand break repair (GO:0000012)4.12097750
63meiotic nuclear division (GO:0007126)4.12080187
64chaperone-mediated protein complex assembly (GO:0051131)4.06344501
65negative regulation of Rho protein signal transduction (GO:0035024)4.05192050
66multicellular organismal development (GO:0007275)3.91502020
67meiosis I (GO:0007127)3.69540345
68genitalia morphogenesis (GO:0035112)3.64185951
69sequestering of actin monomers (GO:0042989)3.62674807
70musculoskeletal movement (GO:0050881)3.59488112
71multicellular organismal movement (GO:0050879)3.59488112
72protein-DNA complex disassembly (GO:0032986)3.59199846
73nucleosome disassembly (GO:0006337)3.59199846
74protein polyglutamylation (GO:0018095)3.55485161
75response to acidic pH (GO:0010447)3.51683054
76protein K11-linked deubiquitination (GO:0035871)3.50949783
77glomerular visceral epithelial cell development (GO:0072015)3.45867339
78regulation of somitogenesis (GO:0014807)3.39881355
79glomerular epithelial cell development (GO:0072310)3.34785145
80cellular response to pH (GO:0071467)3.32012077
81histone H3-K9 demethylation (GO:0033169)3.31579855
82cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.31523293
83microtubule polymerization or depolymerization (GO:0031109)3.30300138
84membrane protein intracellular domain proteolysis (GO:0031293)3.29285532
85regulation of spindle checkpoint (GO:0090231)3.25305036
86meiotic cell cycle (GO:0051321)3.24042746
87peptidyl-threonine dephosphorylation (GO:0035970)3.23521061
88protein depolymerization (GO:0051261)3.18885418
89regulation of phosphoprotein phosphatase activity (GO:0043666)3.18630566
90regulation of interleukin-13 production (GO:0032656)3.18322618
91monoubiquitinated protein deubiquitination (GO:0035520)3.18188427
92cerebral cortex neuron differentiation (GO:0021895)3.14873438
93carnitine transport (GO:0015879)3.13893446
94amino-acid betaine transport (GO:0015838)3.13893446
95glycolytic process (GO:0006096)3.13578533
96cranial nerve morphogenesis (GO:0021602)3.13307334
97negative regulation of gene expression, epigenetic (GO:0045814)3.12004534
98protein refolding (GO:0042026)3.11285717
99protein localization to cilium (GO:0061512)3.10471733
100nucleoside diphosphate phosphorylation (GO:0006165)3.09737295
101homeostasis of number of cells within a tissue (GO:0048873)3.06394682
102regulation of T-helper 2 cell differentiation (GO:0045628)3.06315331
103nucleus organization (GO:0006997)3.05481969
104mesenchymal cell differentiation involved in kidney development (GO:0072161)3.04314615
105mesenchymal cell differentiation involved in renal system development (GO:2001012)3.04314615
106cell differentiation involved in metanephros development (GO:0072202)3.03465456
107positive regulation of macrophage activation (GO:0043032)3.03320969
108interferon-gamma secretion (GO:0072643)3.01244817
109polyol catabolic process (GO:0046174)3.00995107
110GTP biosynthetic process (GO:0006183)3.00490691
111microtubule nucleation (GO:0007020)2.98453266
112carnitine transmembrane transport (GO:1902603)2.97375375
113mitotic sister chromatid cohesion (GO:0007064)2.95702562
114DNA conformation change (GO:0071103)2.93700677
115alditol metabolic process (GO:0019400)2.92868148
116cilium organization (GO:0044782)2.83200925
117receptor recycling (GO:0001881)2.81579662
118synapsis (GO:0007129)2.81025070
119NAD biosynthetic process (GO:0009435)2.79805231
120polyamine biosynthetic process (GO:0006596)2.79357746
121negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.78577299
122microtubule-based movement (GO:0007018)2.77484250
123cilium morphogenesis (GO:0060271)2.73963732
124cilium assembly (GO:0042384)2.72679790
125mitotic G1 DNA damage checkpoint (GO:0031571)2.71513884
126cellular component assembly involved in morphogenesis (GO:0010927)2.71383375
127intraciliary transport (GO:0042073)2.70067959
128meiotic cell cycle process (GO:1903046)2.69201547
129RNA destabilization (GO:0050779)2.67023418
130UTP biosynthetic process (GO:0006228)2.66854708
131lactate metabolic process (GO:0006089)2.64351537
132axoneme assembly (GO:0035082)2.63860373
133RNA localization (GO:0006403)2.63629680
134regulation of cilium assembly (GO:1902017)2.60280908
135peptidyl-glutamic acid modification (GO:0018200)2.58651136
136chromatin silencing (GO:0006342)2.53348434
137negative regulation of organelle assembly (GO:1902116)2.50624785
138glycerol metabolic process (GO:0006071)2.47652090
139UTP metabolic process (GO:0046051)2.42801343
140sperm motility (GO:0030317)14.0928228
141cell wall macromolecule catabolic process (GO:0016998)13.8419515
142cell wall macromolecule metabolic process (GO:0044036)13.8419515
143fusion of sperm to egg plasma membrane (GO:0007342)13.4838257
144acrosome reaction (GO:0007340)12.2657534
145acrosome assembly (GO:0001675)11.9405745
146sperm-egg recognition (GO:0035036)11.8076873
147multicellular organism reproduction (GO:0032504)11.1152712
148binding of sperm to zona pellucida (GO:0007339)10.7358427
149cell-cell recognition (GO:0009988)10.5602788
150plasma membrane fusion (GO:0045026)10.2630446

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.05290095
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.43094917
3EZH2_22144423_ChIP-Seq_EOC_Human4.30269547
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.03755804
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.93038725
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.75087180
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.24531999
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.99693418
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.70257479
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.65874718
11VDR_22108803_ChIP-Seq_LS180_Human2.58897249
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.41235203
13VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.17213259
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.10381786
15ZNF274_21170338_ChIP-Seq_K562_Hela2.09033523
16ELF1_20517297_ChIP-Seq_JURKAT_Human2.08802686
17CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.06571340
18GATA1_26923725_Chip-Seq_HPCs_Mouse2.06492416
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.04812707
20EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.02417688
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01924924
22ERA_21632823_ChIP-Seq_H3396_Human1.98346571
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.96035401
24FUS_26573619_Chip-Seq_HEK293_Human1.92557466
25RAC3_21632823_ChIP-Seq_H3396_Human1.92045985
26KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.91032485
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85454988
28CTCF_27219007_Chip-Seq_Bcells_Human1.85029529
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81751874
30RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.81055891
31DROSHA_22980978_ChIP-Seq_HELA_Human1.80648680
32EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.77710096
33TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.74081510
34* NANOG_20526341_ChIP-Seq_ESCs_Human1.73952009
35STAT1_17558387_ChIP-Seq_HELA_Human1.72374848
36MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.69497409
37ELK4_26923725_Chip-Seq_MESODERM_Mouse1.68276708
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.64132711
39BCL6_27268052_Chip-Seq_Bcells_Human1.64087718
40FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63336392
41TDRD3_21172665_ChIP-Seq_MCF-7_Human1.61322882
42ARNT_22903824_ChIP-Seq_MCF-7_Human1.61185597
43SMC4_20622854_ChIP-Seq_HELA_Human1.61154949
44TAF2_19829295_ChIP-Seq_ESCs_Human1.61073336
45MYC_19829295_ChIP-Seq_ESCs_Human1.60540166
46E2F1_20622854_ChIP-Seq_HELA_Human1.60404689
47SOX2_22085726_ChIP-Seq_NPCs_Mouse1.59531017
48* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58513124
49RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.55642240
50ER_23166858_ChIP-Seq_MCF-7_Human1.55108438
51GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.54921399
52GATA3_21867929_ChIP-Seq_CD8_Mouse1.53293565
53KDM2B_26808549_Chip-Seq_REH_Human1.53127896
54BCOR_27268052_Chip-Seq_Bcells_Human1.52524568
55WDR5_24793694_ChIP-Seq_LNCAP_Human1.52023233
56AUTS2_25519132_ChIP-Seq_293T-REX_Human1.51627564
57CTCF_20526341_ChIP-Seq_ESCs_Human1.50856970
58SMAD4_21741376_ChIP-Seq_EPCs_Human1.50680310
59PHF8_20622854_ChIP-Seq_HELA_Human1.50581866
60P68_20966046_ChIP-Seq_HELA_Human1.50459427
61TAL1_26923725_Chip-Seq_HPCs_Mouse1.49578485
62TP63_22573176_ChIP-Seq_HFKS_Human1.48953849
63TP53_18474530_ChIP-ChIP_U2OS_Human1.48499764
64KAP1_22055183_ChIP-Seq_ESCs_Mouse1.48445295
65OCT4_20526341_ChIP-Seq_ESCs_Human1.46368287
66CBP_20019798_ChIP-Seq_JUKART_Human1.44307074
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44307074
68LXR_22292898_ChIP-Seq_THP-1_Human1.43691888
69AR_25329375_ChIP-Seq_VCAP_Human1.39753417
70REST_21632747_ChIP-Seq_MESCs_Mouse1.39191306
71SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37857175
72PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.37555770
73CBX2_22325352_ChIP-Seq_293T-Rex_Human1.37283484
74ETV2_25802403_ChIP-Seq_MESCs_Mouse1.36840537
75BP1_19119308_ChIP-ChIP_Hs578T_Human1.34808996
76CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.34434692
77RBPJ_21746931_ChIP-Seq_IB4_Human1.33959910
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.33454304
79FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.33446710
80P300_27268052_Chip-Seq_Bcells_Human1.33269258
81LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.32614856
82P53_21459846_ChIP-Seq_SAOS-2_Human1.32596059
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31870539
84SUZ12_27294783_Chip-Seq_ESCs_Mouse1.31397544
85SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.31122587
86ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30303486
87SMAD3_21741376_ChIP-Seq_ESCs_Human1.29690413
88* HNFA_21074721_ChIP-Seq_CACO-2_Human1.27964413
89GATA3_21867929_ChIP-Seq_TH1_Mouse1.27877678
90FLI1_21867929_ChIP-Seq_TH2_Mouse1.27380651
91ETV1_20927104_ChIP-Seq_GIST48_Human1.27316499
92P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.26976384
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26267554
94SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.25715104
95GATA3_21878914_ChIP-Seq_MCF-7_Human1.25142902
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24318420
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24102981
98RUNX_20019798_ChIP-Seq_JUKART_Human1.23427185
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23313718
100SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23212187
101CEBPB_22108803_ChIP-Seq_LS180_Human1.22096677
102GF1_26923725_Chip-Seq_HPCs_Mouse1.22035470
103KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.19583309
104TBL1_22424771_ChIP-Seq_293T_Human1.19352778
105RAD21_21589869_ChIP-Seq_MESCs_Mouse1.19053139
106SMAD4_21741376_ChIP-Seq_HESCs_Human1.16407776
107* SMAD3_21741376_ChIP-Seq_EPCs_Human1.16091866
108PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15869135
109ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14773996
110SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.14735443
111CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14435591
112TP63_19390658_ChIP-ChIP_HaCaT_Human1.13757943
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13668143
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13668143
115CRX_20693478_ChIP-Seq_RETINA_Mouse1.13643314
116NANOG_18555785_Chip-Seq_ESCs_Mouse1.12707164
117EZH2_27294783_Chip-Seq_ESCs_Mouse1.11982335
118* P300_19829295_ChIP-Seq_ESCs_Human1.11324674
119PHF8_20622853_ChIP-Seq_HELA_Human1.11173859
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10993838
121CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10185342
122ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09845005
123SA1_27219007_Chip-Seq_Bcells_Human1.09710933
124PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09236047
125KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08795962
126ERG_20517297_ChIP-Seq_VCAP_Human1.08610480
127GATA6_21074721_ChIP-Seq_CACO-2_Human1.08131248
128SMRT_27268052_Chip-Seq_Bcells_Human1.07186215
129SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06788734
130ESET_19884257_ChIP-Seq_ESCs_Mouse1.06627561
131SPI1_26923725_Chip-Seq_HPCs_Mouse1.05180799
132RUNX2_22187159_ChIP-Seq_PCA_Human1.04918684
133OCT1_27270436_Chip-Seq_PROSTATE_Human1.04727261
134* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04628239
135RUNX1_26923725_Chip-Seq_HPCs_Mouse1.04101266
136EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03112026
137EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02056137
138MYC_27129775_Chip-Seq_CORNEA_Mouse1.02017647
139* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.01953937
140NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01749100
141P53_22387025_ChIP-Seq_ESCs_Mouse1.01576425
142RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01230475
143NFYA_21822215_ChIP-Seq_K562_Human1.00779342
144OCT4_18555785_Chip-Seq_ESCs_Mouse1.00757276
145NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00594841
146* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99493835
147GATA1_19941827_ChIP-Seq_MEL86_Mouse0.99419044
148PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.99128300
149EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98868862
150SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98833029
151CMYC_18555785_Chip-Seq_ESCs_Mouse0.98627454
152HOXB7_26014856_ChIP-Seq_BT474_Human0.98421766
153GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.98400609
154PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97508769
155TAF15_26573619_Chip-Seq_HEK293_Human0.97396352
156SA1_27219007_Chip-Seq_ERYTHROID_Human0.97369102
157E2F1_17053090_ChIP-ChIP_MCF-7_Human0.96868159
158LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96667381
159OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96501517
160RNF2_27304074_Chip-Seq_NSC_Mouse0.96255407
161TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95096767
162EZH2_27294783_Chip-Seq_NPCs_Mouse0.95014029
163KLF4_18555785_Chip-Seq_ESCs_Mouse0.94408378
164JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.93627843
165RARA_24833708_ChIP-Seq_LIVER_Mouse0.93602959
166MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93526844
167P300_18555785_Chip-Seq_ESCs_Mouse0.93048400
168YY1_22570637_ChIP-Seq_MALME-3M_Human0.92591613
169SOX11_22085726_ChIP-Seq_ESNs_Mouse0.91773269
170ESRRB_18555785_Chip-Seq_ESCs_Mouse0.91409631
171FLI1_21867929_ChIP-Seq_CD8_Mouse0.90400562
172SOX9_26525672_Chip-Seq_HEART_Mouse0.90381494
173PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90189938
174NFYB_21822215_ChIP-Seq_K562_Human0.89657876
175TET1_21451524_ChIP-Seq_MESCs_Mouse0.89542674
176SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88490148

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive6.00844536
2* MP0001929_abnormal_gametogenesis5.42384194
3MP0008877_abnormal_DNA_methylation3.81496145
4MP0002210_abnormal_sex_determination3.31939450
5MP0001348_abnormal_lacrimal_gland3.30531781
6* MP0002161_abnormal_fertility/fecundity3.26334790
7MP0005670_abnormal_white_adipose2.86333470
8MP0001145_abnormal_male_reproductive2.83095452
9MP0000678_abnormal_parathyroid_gland2.60948194
10MP0000653_abnormal_sex_gland2.44099321
11MP0002653_abnormal_ependyma_morphology2.29360379
12MP0003718_maternal_effect2.20580562
13MP0002132_abnormal_respiratory_system2.10038804
14MP0005410_abnormal_fertilization16.6976530
15MP0002249_abnormal_larynx_morphology1.67154959
16MP0005379_endocrine/exocrine_gland_phen1.61716181
17MP0002160_abnormal_reproductive_system1.48906273
18MP0001485_abnormal_pinna_reflex1.46409362
19MP0004510_myositis1.44790033
20MP0005310_abnormal_salivary_gland1.42642305
21MP0005623_abnormal_meninges_morphology1.41031364
22MP0001486_abnormal_startle_reflex1.39683668
23MP0009053_abnormal_anal_canal1.37976608
24MP0004233_abnormal_muscle_weight1.33078002
25MP0003646_muscle_fatigue1.32695577
26MP0002138_abnormal_hepatobiliary_system1.25844981
27MP0002282_abnormal_trachea_morphology1.24799142
28MP0002127_abnormal_cardiovascular_syste1.16564863
29MP0004859_abnormal_synaptic_plasticity1.15197366
30MP0001765_abnormal_ion_homeostasis1.14853915
31MP0005248_abnormal_Harderian_gland1.14683884
32MP0001984_abnormal_olfaction1.12336614
33MP0002735_abnormal_chemical_nociception1.08995993
34MP0001963_abnormal_hearing_physiology1.05439664
35MP0005395_other_phenotype1.04092717
36MP0000026_abnormal_inner_ear0.95620820
37MP0005647_abnormal_sex_gland0.91977399
38MP0005451_abnormal_body_composition0.90248790
39MP0009046_muscle_twitch0.88396117
40MP0003011_delayed_dark_adaptation0.86374041
41MP0000681_abnormal_thyroid_gland0.85968032
42MP0002234_abnormal_pharynx_morphology0.85391305
43MP0000955_abnormal_spinal_cord0.82154053
44MP0008995_early_reproductive_senescence0.80006906
45MP0000049_abnormal_middle_ear0.79434876
46MP0001879_abnormal_lymphatic_vessel0.76643138
47MP0004085_abnormal_heartbeat0.75105932
48MP0008058_abnormal_DNA_repair0.74254970
49MP0005389_reproductive_system_phenotype0.71816499
50MP0005083_abnormal_biliary_tract0.71202604
51MP0005636_abnormal_mineral_homeostasis0.69483352
52MP0002733_abnormal_thermal_nociception0.69380020
53MP0000569_abnormal_digit_pigmentation0.69095949
54MP0002067_abnormal_sensory_capabilities0.68404172
55MP0003115_abnormal_respiratory_system0.67650406
56MP0004484_altered_response_of0.65719206
57MP0002736_abnormal_nociception_after0.64706177
58MP0000516_abnormal_urinary_system0.63661817
59MP0005367_renal/urinary_system_phenotyp0.63661817
60MP0002557_abnormal_social/conspecific_i0.62363639
61MP0005666_abnormal_adipose_tissue0.61412108
62MP0001986_abnormal_taste_sensitivity0.60956433
63MP0001905_abnormal_dopamine_level0.59221691
64MP0004742_abnormal_vestibular_system0.59193347
65MP0005167_abnormal_blood-brain_barrier0.58536533
66MP0001666_abnormal_nutrient_absorption0.57914588
67MP0009697_abnormal_copulation0.55883138
68MP0003329_amyloid_beta_deposits0.55313915
69MP0005377_hearing/vestibular/ear_phenot0.55204755
70MP0003878_abnormal_ear_physiology0.55204755
71MP0005423_abnormal_somatic_nervous0.54714529
72MP0001324_abnormal_eye_pigmentation0.52534688
73MP0004036_abnormal_muscle_relaxation0.50799075
74MP0001764_abnormal_homeostasis0.50791871
75MP0002272_abnormal_nervous_system0.50367890
76MP0003137_abnormal_impulse_conducting0.49216334
77MP0000003_abnormal_adipose_tissue0.48436758
78MP0005253_abnormal_eye_physiology0.47978900
79MP0005551_abnormal_eye_electrophysiolog0.47396194
80MP0001970_abnormal_pain_threshold0.47171257
81MP0003119_abnormal_digestive_system0.45613552
82MP0001501_abnormal_sleep_pattern0.45021827
83MP0000249_abnormal_blood_vessel0.44967559
84MP0003699_abnormal_female_reproductive0.44417199
85MP0000470_abnormal_stomach_morphology0.43610604
86MP0000613_abnormal_salivary_gland0.43467456
87MP0000566_synostosis0.43322421
88MP0001968_abnormal_touch/_nociception0.43001687
89MP0002734_abnormal_mechanical_nocicepti0.42622607
90MP0000534_abnormal_ureter_morphology0.42018367
91MP0003077_abnormal_cell_cycle0.41461664
92MP0003950_abnormal_plasma_membrane0.41320207
93MP0008961_abnormal_basal_metabolism0.40830723
94MP0005535_abnormal_body_temperature0.40405010
95MP0002269_muscular_atrophy0.40229622
96MP0002102_abnormal_ear_morphology0.40068046
97MP0000230_abnormal_systemic_arterial0.39185217
98MP0001440_abnormal_grooming_behavior0.39068543
99MP0003936_abnormal_reproductive_system0.38424809
100MP0005408_hypopigmentation0.37970185
101MP0009745_abnormal_behavioral_response0.36933250
102MP0000358_abnormal_cell_content/0.36882887
103MP0005084_abnormal_gallbladder_morpholo0.36360477
104MP0004133_heterotaxia0.35876123
105MP0003880_abnormal_central_pattern0.34698003
106MP0001293_anophthalmia0.34101146
107MP0010094_abnormal_chromosome_stability0.33722078
108MP0002928_abnormal_bile_duct0.33459294
109MP0006036_abnormal_mitochondrial_physio0.33392627
110MP0005166_decreased_susceptibility_to0.32999757
111MP0005595_abnormal_vascular_smooth0.32620798
112MP0003633_abnormal_nervous_system0.32567543
113MP0005391_vision/eye_phenotype0.31359134
114MP0009278_abnormal_bone_marrow0.30501344
115MP0003942_abnormal_urinary_system0.30440005
116MP0009115_abnormal_fat_cell0.30432882
117MP0002971_abnormal_brown_adipose0.29766931
118MP0002295_abnormal_pulmonary_circulatio0.27815819
119MP0002139_abnormal_hepatobiliary_system0.27800395
120MP0002152_abnormal_brain_morphology0.27666244
121MP0001545_abnormal_hematopoietic_system0.27281676
122MP0005397_hematopoietic_system_phenotyp0.27281676
123MP0003861_abnormal_nervous_system0.26288245
124MP0000604_amyloidosis0.25828276
125MP0008057_abnormal_DNA_replication0.25590885
126MP0005174_abnormal_tail_pigmentation0.25232969
127MP0003631_nervous_system_phenotype0.24977425
128MP0004043_abnormal_pH_regulation0.24483472
129MP0001661_extended_life_span0.23874440
130MP0002169_no_abnormal_phenotype0.23656430
131MP0002873_normal_phenotype0.23385336
132MP0004811_abnormal_neuron_physiology0.23071344
133MP0004019_abnormal_vitamin_homeostasis0.22548007
134MP0010307_abnormal_tumor_latency0.22228891
135MP0006072_abnormal_retinal_apoptosis0.20799809
136MP0001119_abnormal_female_reproductive0.20354961
137MP0003948_abnormal_gas_homeostasis0.19700078
138MP0001529_abnormal_vocalization0.19109288
139MP0002108_abnormal_muscle_morphology0.18802138
140MP0001849_ear_inflammation0.18471945
141MP0002572_abnormal_emotion/affect_behav0.18120264
142MP0002229_neurodegeneration0.17963506
143MP0006035_abnormal_mitochondrial_morpho0.17697489
144MP0003045_fibrosis0.17399989
145MP0008875_abnormal_xenobiotic_pharmacok0.17004498
146MP0003786_premature_aging0.16674284
147MP0003879_abnormal_hair_cell0.16623841
148MP0005195_abnormal_posterior_eye0.15426988
149MP0003111_abnormal_nucleus_morphology0.15273721
150MP0002752_abnormal_somatic_nervous0.15086421
151MP0000001_mammalian_phenotype0.14925418
152MP0001730_embryonic_growth_arrest0.14514232
153MP0002822_catalepsy0.14494782
154MP0004270_analgesia0.14061965
155MP0005375_adipose_tissue_phenotype0.13861790
156MP0000462_abnormal_digestive_system0.13529705
157MP0008569_lethality_at_weaning0.13253435
158MP0005319_abnormal_enzyme/_coenzyme0.13218880
159MP0004145_abnormal_muscle_electrophysio0.12935664

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.50173523
2Abnormal respiratory motile cilium morphology (HP:0005938)9.33042528
3Abnormal respiratory epithelium morphology (HP:0012253)9.33042528
4Severe visual impairment (HP:0001141)8.29851706
5Abnormal ciliary motility (HP:0012262)7.63242757
6Rhinitis (HP:0012384)7.60427051
7Chronic bronchitis (HP:0004469)7.34430906
8Infertility (HP:0000789)6.86829872
9Nasal polyposis (HP:0100582)6.30608032
10Abnormality of the nasal mucosa (HP:0000433)5.17431439
11Bony spicule pigmentary retinopathy (HP:0007737)5.02435553
12Attenuation of retinal blood vessels (HP:0007843)5.01620820
13Resting tremor (HP:0002322)4.86005919
14Male infertility (HP:0003251)4.60099437
15Bronchitis (HP:0012387)4.51868388
16Chronic hepatic failure (HP:0100626)4.51428331
17Bronchiectasis (HP:0002110)4.44687751
18Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.40404945
19Facial shape deformation (HP:0011334)4.34660822
20Potter facies (HP:0002009)4.34660822
21Hyperkalemia (HP:0002153)4.32604091
22Abnormal rod and cone electroretinograms (HP:0008323)4.15466481
23Nephronophthisis (HP:0000090)4.06703165
24Abnormality of macular pigmentation (HP:0008002)4.04717713
25Hypoplastic ischia (HP:0003175)3.83683287
26Enlarged epiphyses (HP:0010580)3.58542123
27Abnormal spermatogenesis (HP:0008669)3.50559100
28Aplasia/Hypoplasia of the earlobes (HP:0009906)3.49578997
29Abnormality of the ischium (HP:0003174)3.42166769
30Recurrent sinusitis (HP:0011108)3.35929289
31Recurrent otitis media (HP:0000403)3.25453276
32Unilateral renal agenesis (HP:0000122)3.18924175
33Hypoplasia of the thymus (HP:0000778)3.16281916
34Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.11716744
35Postural instability (HP:0002172)3.10187624
36Abnormality of the renal medulla (HP:0100957)3.05196376
37Progressive sensorineural hearing impairment (HP:0000408)3.05139667
38Hypoalphalipoproteinemia (HP:0003233)2.93735326
39Abnormality of the aortic arch (HP:0012303)2.88644535
40Generalized aminoaciduria (HP:0002909)2.69103221
41Tubulointerstitial nephritis (HP:0001970)2.68271804
42Impulsivity (HP:0100710)2.64514134
43Recurrent bronchitis (HP:0002837)2.63493377
44Amelogenesis imperfecta (HP:0000705)2.60088233
45Molar tooth sign on MRI (HP:0002419)2.55885622
46Abnormality of midbrain morphology (HP:0002418)2.55885622
47Truncal obesity (HP:0001956)2.55660979
48Medial flaring of the eyebrow (HP:0010747)2.52728119
49Abnormality of potassium homeostasis (HP:0011042)2.50125359
50Progressive cerebellar ataxia (HP:0002073)2.49190918
51Tubular atrophy (HP:0000092)2.48316787
52Insulin-resistant diabetes mellitus (HP:0000831)2.46774575
53Cholecystitis (HP:0001082)2.44074589
54Abnormal gallbladder physiology (HP:0012438)2.44074589
55Decreased central vision (HP:0007663)2.43565696
56Renovascular hypertension (HP:0100817)2.42754068
57Menstrual irregularities (HP:0000858)2.41822603
58Abnormality of dental color (HP:0011073)2.40656670
59Portal hypertension (HP:0001409)2.37704365
60Abnormality of the costochondral junction (HP:0000919)2.37020215
61Ventricular tachycardia (HP:0004756)2.35585076
62Flattened epiphyses (HP:0003071)2.33953400
63Widely patent fontanelles and sutures (HP:0004492)2.33867638
64Gonadotropin excess (HP:0000837)2.29539413
65Tubulointerstitial abnormality (HP:0001969)2.29317464
66Abnormality of the parathyroid morphology (HP:0011766)2.27187243
67Azoospermia (HP:0000027)2.20084007
68Epiphyseal dysplasia (HP:0002656)2.19108634
69Abnormality of the hepatic vasculature (HP:0006707)2.17574272
70Osteomalacia (HP:0002749)2.13000133
71Polyuria (HP:0000103)2.11903980
72Dyschromatopsia (HP:0007641)2.10395692
73Abnormality of the epiphysis of the femoral head (HP:0010574)2.03431389
74Tetany (HP:0001281)2.02662182
75Focal segmental glomerulosclerosis (HP:0000097)2.02635563
76Hyponatremia (HP:0002902)2.01741110
77Dynein arm defect of respiratory motile cilia (HP:0012255)13.4766738
78Absent/shortened dynein arms (HP:0200106)13.4766738
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1012808
80Hypophosphatemic rickets (HP:0004912)1.97232344
81Progressive hearing impairment (HP:0001730)1.93515387
82Abnormality of the pubic bones (HP:0003172)1.92811085
83Choroideremia (HP:0001139)1.92228574
84Increased purine levels (HP:0004368)1.90503360
85Hyperuricemia (HP:0002149)1.90503360
86Spastic tetraparesis (HP:0001285)1.90431184
87Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.89473095
88Abnormality of femoral epiphyses (HP:0006499)1.89473095
89Myokymia (HP:0002411)1.89311463
90Recurrent pneumonia (HP:0006532)1.87129349
91Transposition of the great arteries (HP:0001669)1.86749723
92Abnormal connection of the cardiac segments (HP:0011545)1.86749723
93Abnormal ventriculo-arterial connection (HP:0011563)1.86749723
94Hyperthyroidism (HP:0000836)1.85408477
95Bradycardia (HP:0001662)1.85185837
96Optic nerve hypoplasia (HP:0000609)1.84886849
97Tubulointerstitial fibrosis (HP:0005576)1.84799266
98Abnormality of the femoral head (HP:0003368)1.84535778
99Recurrent corneal erosions (HP:0000495)1.84523023
100Flat capital femoral epiphysis (HP:0003370)1.82733311
101Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80402275
102Stage 5 chronic kidney disease (HP:0003774)1.79910097
103Hypoparathyroidism (HP:0000829)1.78366012
104Mixed hearing impairment (HP:0000410)1.76658847
105Fibular hypoplasia (HP:0003038)1.73692263
106Polydipsia (HP:0001959)1.72322690
107Abnormal drinking behavior (HP:0030082)1.72322690
108Postaxial foot polydactyly (HP:0001830)1.72170447
109Hemorrhage of the eye (HP:0011885)1.69525277
110Heterotopia (HP:0002282)1.66583959
111Congenital malformation of the right heart (HP:0011723)1.63822905
112Double outlet right ventricle (HP:0001719)1.63822905
113Abnormality of the renal cortex (HP:0011035)1.62634338
114Abnormality of renal excretion (HP:0011036)1.62417353
115Hypoplasia of the capital femoral epiphysis (HP:0003090)1.62216712
116Congenital hepatic fibrosis (HP:0002612)1.60788539
117Aplasia/Hypoplasia of the lens (HP:0008063)1.55239081
118Short ribs (HP:0000773)1.54701859
119Abnormality of permanent molar morphology (HP:0011071)1.53846457
120Abnormality of the dental root (HP:0006486)1.53846457
121Taurodontia (HP:0000679)1.53846457
122Abnormal biliary tract physiology (HP:0012439)1.52997528
123Bile duct proliferation (HP:0001408)1.52997528
124Neurofibrillary tangles (HP:0002185)1.52568501
125Oculomotor apraxia (HP:0000657)1.50579059
126Chronic sinusitis (HP:0011109)1.47025291
127Renal dysplasia (HP:0000110)1.46585759
128Abnormality of dentin (HP:0010299)1.45698094
129Abnormality of molar morphology (HP:0011070)1.43533752
130Abnormality of molar (HP:0011077)1.43533752
131Bell-shaped thorax (HP:0001591)1.43339082
132Abnormality of the dental pulp (HP:0006479)1.43164401
133Gait imbalance (HP:0002141)1.42925129
134Congenital primary aphakia (HP:0007707)1.42773809
135Facial cleft (HP:0002006)1.41364570
136Postaxial hand polydactyly (HP:0001162)1.40967124
137Bundle branch block (HP:0011710)1.38192617
138Asymmetric septal hypertrophy (HP:0001670)1.36621902
139Abnormal urine output (HP:0012590)1.31440137
140Cystic liver disease (HP:0006706)1.30591232
141Abnormality of the lower motor neuron (HP:0002366)1.30472871
142Sensory axonal neuropathy (HP:0003390)1.29794927
143Cone-rod dystrophy (HP:0000548)1.29614181
144Easy fatigability (HP:0003388)1.29033122
145Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.28369052
146Absent epiphyses (HP:0010577)1.26938511
147Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.26938511
148Deformed sella turcica (HP:0002681)1.25736252
149Hemiparesis (HP:0001269)1.25502545
150Microglossia (HP:0000171)1.22888222
151Abnormality of the neuromuscular junction (HP:0003398)1.22016902
152Fatigable weakness (HP:0003473)1.22016902
153Cerebral inclusion bodies (HP:0100314)1.21107404
154Abnormality of saccadic eye movements (HP:0000570)1.20918480
155Exercise-induced myalgia (HP:0003738)1.20570831
156Nephrogenic diabetes insipidus (HP:0009806)1.18047320
157Absent frontal sinuses (HP:0002688)1.17797017
158Abnormality of ocular smooth pursuit (HP:0000617)1.17098818
159Short femoral neck (HP:0100864)1.16883360
160Impaired proprioception (HP:0010831)1.16655586
161Nephropathy (HP:0000112)1.16257664
162Cerebellar dysplasia (HP:0007033)1.16026894
163Pancreatic fibrosis (HP:0100732)1.14412004
164Hypercholesterolemia (HP:0003124)1.14114509
165Median cleft lip (HP:0000161)1.13520522

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.20418022
2PDK48.20418022
3TESK16.30618253
4PDK25.29074767
5PRKD35.05330683
6DDR24.92204343
7ICK4.36771085
8INSRR3.99317668
9MAP4K23.72684673
10BRD43.15876517
11PLK23.01684075
12WNK42.30797904
13PTK2B2.19053175
14STK392.15526975
15STK381.99041422
16PIK3CG1.93359557
17MST1R1.82403685
18PNCK1.71218040
19DYRK1B1.63179153
20NEK21.46255046
21CDK121.39720782
22PDK11.24935007
23CDK71.23452932
24KSR21.12538248
25MAP3K91.10874207
26DYRK30.88158237
27WNK10.87652417
28PASK0.86850790
29AKT30.85705683
30TYRO30.85540223
31LATS20.83773012
32IRAK10.83210389
33CAMK1D0.82460074
34MAPK150.80557478
35PDPK10.77300846
36RPS6KA20.71237695
37MAP2K60.70631032
38STK30.70571770
39UHMK10.70186161
40MAP3K110.67260735
41RIPK40.67133683
42MAP3K20.66854447
43MAP2K20.64036221
44PRKAA20.62684472
45CCNB10.61207112
46ROCK10.59063324
47SIK20.59018608
48NTRK20.59013096
49LMTK20.56586131
50CAMK10.56476182
51CDK30.56278897
52TTK0.54777510
53MUSK0.54261040
54MAP3K80.53861532
55TESK20.53266680
56CHEK20.52051626
57STK38L0.50967970
58EEF2K0.49957475
59SGK4940.49951403
60SGK2230.49951403
61IRAK20.49680401
62PINK10.47471760
63CAMK1G0.47404690
64CDK40.45677413
65BMPR1B0.42492841
66MAPK10.40757565
67TIE10.39938357
68MAP3K10.39516892
69PRKCG0.39332230
70PAK10.38431977
71MAP3K40.36588565
72RPS6KC10.35814933
73RPS6KL10.35814933
74CAMK40.35327697
75ARAF0.35213854
76CHEK10.33200087
77RPS6KA60.32913074
78NTRK30.32608359
79MARK20.32006992
80PAK20.29852511
81CAMKK10.29494802
82SGK10.26631257
83MAP2K70.24546394
84ATM0.23786036
85MET0.23677192
86MAP3K100.23207488
87MAPK140.21615168
88BRSK20.21366787
89MTOR0.20646565
90PAK40.20538806
91MAPKAPK50.20001423
92PLK40.19712735
93ATR0.19289996
94MAPK100.19272852
95WEE10.19256129
96TLK10.19241426
97PRKCZ0.18028087
98ZAK0.17472646
99PRKAA10.17378660
100NEK60.16450669
101PRKCQ0.15625439
102AKT10.15463010
103EPHB10.15451620
104CDK150.13426835
105BLK0.13351251
106RPS6KB10.13304481
107CDC70.13294557
108PKN10.12514809
109MAPK110.11904052
110LATS10.11893190
111CDK180.10597329
112CDK11A0.09785967
113CAMK2A0.09423180
114RPS6KA10.08966981
115FER0.08939737
116BRSK10.08637792
117FRK0.08522892
118PLK10.08289662
119SGK20.07919390
120MAPK90.07658792
121PRKG10.06962270
122CSNK2A10.06790316
123OXSR10.06731872
124PRKG20.06378902
125GSK3B0.06031871
126BRAF0.05890391
127CDK140.05865434
128MINK10.05432723
129PRKACG0.05091332
130CSNK1D0.04486639
131STK110.04298357
132PRKCA0.03118510
133CSNK2A20.03081171
134MAPK80.02568216
135PRKCB0.02494626
136MARK30.02281324
137CDK10.02209826
138CLK10.02149878
139PRKCD0.01807244
140CSF1R0.00713910
141ZAP700.00543587
142EGFR0.00360203
143CDK20.00275677
144STK100.00226291
145PRKACB-0.0344244
146CDK6-0.0281902
147PAK6-0.0263220
148WNK3-0.0260080
149PIM1-0.0187420
150PDGFRB-0.0168820
151RPS6KA3-0.0131303
152AURKA-0.0118653
153MARK1-0.0116214
154PRKACA-0.0052175
155MAP3K5-0.0017098

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000728.06993075
2Fatty acid biosynthesis_Homo sapiens_hsa000614.61681873
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.37873173
4Vitamin B6 metabolism_Homo sapiens_hsa007503.69476637
5Pyruvate metabolism_Homo sapiens_hsa006203.48728015
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.33259778
7Linoleic acid metabolism_Homo sapiens_hsa005913.24871750
8Butanoate metabolism_Homo sapiens_hsa006502.85304249
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.84182956
10Propanoate metabolism_Homo sapiens_hsa006402.79812621
11Glucagon signaling pathway_Homo sapiens_hsa049222.45741558
12Carbohydrate digestion and absorption_Homo sapiens_hsa049732.30520197
13Basal transcription factors_Homo sapiens_hsa030222.13088896
14PPAR signaling pathway_Homo sapiens_hsa033202.08866884
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.00328170
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.99437227
17Glycerolipid metabolism_Homo sapiens_hsa005611.92632389
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.91026982
19Selenocompound metabolism_Homo sapiens_hsa004501.84845460
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.77430949
21Type I diabetes mellitus_Homo sapiens_hsa049401.76675098
22Allograft rejection_Homo sapiens_hsa053301.73296308
23Pentose phosphate pathway_Homo sapiens_hsa000301.70251275
24Phenylalanine metabolism_Homo sapiens_hsa003601.70183333
25Autoimmune thyroid disease_Homo sapiens_hsa053201.68808374
26Glycerophospholipid metabolism_Homo sapiens_hsa005641.65178044
27Type II diabetes mellitus_Homo sapiens_hsa049301.62256919
28Mineral absorption_Homo sapiens_hsa049781.62117732
29Ether lipid metabolism_Homo sapiens_hsa005651.61248039
30Graft-versus-host disease_Homo sapiens_hsa053321.57598358
31Fatty acid metabolism_Homo sapiens_hsa012121.56018062
32Fatty acid degradation_Homo sapiens_hsa000711.53155594
33Oocyte meiosis_Homo sapiens_hsa041141.51355096
34Fat digestion and absorption_Homo sapiens_hsa049751.49870847
35Dorso-ventral axis formation_Homo sapiens_hsa043201.49357662
36Fructose and mannose metabolism_Homo sapiens_hsa000511.47718437
37Amphetamine addiction_Homo sapiens_hsa050311.46078359
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.38195333
39Carbon metabolism_Homo sapiens_hsa012001.37990958
40Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.33837566
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.33400406
42Cardiac muscle contraction_Homo sapiens_hsa042601.31144141
43Arginine and proline metabolism_Homo sapiens_hsa003301.28791383
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20757241
45Viral myocarditis_Homo sapiens_hsa054161.19189424
46Arginine biosynthesis_Homo sapiens_hsa002201.18436459
47Fanconi anemia pathway_Homo sapiens_hsa034601.13454523
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.12049959
49Renin secretion_Homo sapiens_hsa049241.08509625
50Glutathione metabolism_Homo sapiens_hsa004801.04123859
51Huntingtons disease_Homo sapiens_hsa050161.03838117
52Purine metabolism_Homo sapiens_hsa002301.03003653
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.02907574
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99281815
55Arachidonic acid metabolism_Homo sapiens_hsa005900.95510178
56Chemical carcinogenesis_Homo sapiens_hsa052040.94712675
57Insulin secretion_Homo sapiens_hsa049110.89378535
58Antigen processing and presentation_Homo sapiens_hsa046120.89178354
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88307245
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85753809
61Biosynthesis of amino acids_Homo sapiens_hsa012300.85199683
62Hedgehog signaling pathway_Homo sapiens_hsa043400.82028637
63Collecting duct acid secretion_Homo sapiens_hsa049660.81204963
64mRNA surveillance pathway_Homo sapiens_hsa030150.80148651
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78754535
66Bile secretion_Homo sapiens_hsa049760.78227946
67Morphine addiction_Homo sapiens_hsa050320.77790354
68Influenza A_Homo sapiens_hsa051640.76683218
69Tyrosine metabolism_Homo sapiens_hsa003500.75195227
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.71024357
71Renin-angiotensin system_Homo sapiens_hsa046140.68212475
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.66403921
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66201115
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66008934
75Long-term potentiation_Homo sapiens_hsa047200.65772472
76Thyroid hormone synthesis_Homo sapiens_hsa049180.65064580
77Estrogen signaling pathway_Homo sapiens_hsa049150.64523821
78Systemic lupus erythematosus_Homo sapiens_hsa053220.60063389
79Nicotine addiction_Homo sapiens_hsa050330.57455580
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.56279651
81RNA transport_Homo sapiens_hsa030130.55420941
82Calcium signaling pathway_Homo sapiens_hsa040200.54040421
83Pancreatic secretion_Homo sapiens_hsa049720.53713344
84Salivary secretion_Homo sapiens_hsa049700.51579319
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.51300529
86ABC transporters_Homo sapiens_hsa020100.50915568
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50651576
88Protein digestion and absorption_Homo sapiens_hsa049740.48827885
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47244804
90MAPK signaling pathway_Homo sapiens_hsa040100.46360520
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.46192316
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46018157
93Sulfur metabolism_Homo sapiens_hsa009200.44693025
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44392983
95Nitrogen metabolism_Homo sapiens_hsa009100.43459870
96Metabolic pathways_Homo sapiens_hsa011000.43125353
97Taste transduction_Homo sapiens_hsa047420.42459311
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41883343
99Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41197851
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41001143
101Serotonergic synapse_Homo sapiens_hsa047260.40527890
102Tight junction_Homo sapiens_hsa045300.39965081
103Gastric acid secretion_Homo sapiens_hsa049710.39584612
104Synaptic vesicle cycle_Homo sapiens_hsa047210.39140944
105Legionellosis_Homo sapiens_hsa051340.36874151
106AMPK signaling pathway_Homo sapiens_hsa041520.34977422
107Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33970014
108Acute myeloid leukemia_Homo sapiens_hsa052210.33170261
109Inositol phosphate metabolism_Homo sapiens_hsa005620.31792751
110Circadian entrainment_Homo sapiens_hsa047130.31294794
111VEGF signaling pathway_Homo sapiens_hsa043700.31068185
112Cholinergic synapse_Homo sapiens_hsa047250.30744702
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29773230
114Alcoholism_Homo sapiens_hsa050340.29384055
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29353726
116cAMP signaling pathway_Homo sapiens_hsa040240.29270702
117Pyrimidine metabolism_Homo sapiens_hsa002400.26277670
118Oxytocin signaling pathway_Homo sapiens_hsa049210.25529005
119Viral carcinogenesis_Homo sapiens_hsa052030.25273590
120Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.24289920
121GABAergic synapse_Homo sapiens_hsa047270.23217145
122Olfactory transduction_Homo sapiens_hsa047400.22607338
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.22307275
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21732426
125Cocaine addiction_Homo sapiens_hsa050300.21144946
126ECM-receptor interaction_Homo sapiens_hsa045120.20998980
127N-Glycan biosynthesis_Homo sapiens_hsa005100.20625945
128Phototransduction_Homo sapiens_hsa047440.19977782
129Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18687322
130Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.17869788
131Glutamatergic synapse_Homo sapiens_hsa047240.17828575
132Retinol metabolism_Homo sapiens_hsa008300.17391848
133Prolactin signaling pathway_Homo sapiens_hsa049170.16923835
134Herpes simplex infection_Homo sapiens_hsa051680.16805126
135Gap junction_Homo sapiens_hsa045400.12622327
136Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.12294124
137Steroid hormone biosynthesis_Homo sapiens_hsa001400.10867326
138* Endocytosis_Homo sapiens_hsa041440.10257954
139Basal cell carcinoma_Homo sapiens_hsa052170.08459462
140Wnt signaling pathway_Homo sapiens_hsa043100.07262387

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