CAPNS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)4.36698633
2COPI coating of Golgi vesicle (GO:0048205)4.36698633
3plasma membrane repair (GO:0001778)4.11809992
4apoptotic cell clearance (GO:0043277)3.95710928
5hemidesmosome assembly (GO:0031581)3.80163324
6protein retention in ER lumen (GO:0006621)3.75148705
7basement membrane organization (GO:0071711)3.69897936
8negative regulation of erythrocyte differentiation (GO:0045647)3.63981339
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.58837556
10cell-substrate junction assembly (GO:0007044)3.45151050
11epithelial cell-cell adhesion (GO:0090136)3.42480958
12negative regulation of fatty acid transport (GO:2000192)3.38755607
13cell adhesion mediated by integrin (GO:0033627)3.37549304
14negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.31677108
15regulation of SMAD protein import into nucleus (GO:0060390)3.28292530
16growth hormone receptor signaling pathway (GO:0060396)3.26777265
17stress fiber assembly (GO:0043149)3.25385318
18pinocytosis (GO:0006907)3.24025912
19endodermal cell differentiation (GO:0035987)3.21475189
20low-density lipoprotein particle clearance (GO:0034383)3.19293491
21retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.19177111
22regulation of extracellular matrix disassembly (GO:0010715)3.18933806
23regulation of early endosome to late endosome transport (GO:2000641)3.17094300
24protein heterotrimerization (GO:0070208)3.16774938
25positive regulation of Cdc42 GTPase activity (GO:0043089)3.15054204
26regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.11604797
27positive regulation of p38MAPK cascade (GO:1900745)3.10042393
28cellular response to growth hormone stimulus (GO:0071378)3.09042132
29positive regulation of SMAD protein import into nucleus (GO:0060391)3.07589804
30positive regulation of histone deacetylation (GO:0031065)3.02287258
31mannose metabolic process (GO:0006013)3.00333026
32regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.95667772
33activation of Rac GTPase activity (GO:0032863)2.93686015
34desmosome organization (GO:0002934)2.92851441
35negative regulation of cell size (GO:0045792)2.91630772
36positive regulation of receptor recycling (GO:0001921)2.90867803
37bundle of His cell to Purkinje myocyte communication (GO:0086069)2.89955775
38regulation of cholesterol storage (GO:0010885)2.89413757
39vascular endothelial growth factor signaling pathway (GO:0038084)2.88146187
40positive regulation of extracellular matrix organization (GO:1903055)2.87361878
41negative regulation of potassium ion transmembrane transport (GO:1901380)2.86403480
42renal filtration (GO:0097205)2.85473990
43adherens junction assembly (GO:0034333)2.84847153
44keratan sulfate catabolic process (GO:0042340)2.84436340
45regulation of p38MAPK cascade (GO:1900744)2.82573658
46cytoskeletal anchoring at plasma membrane (GO:0007016)2.80849092
47peptidyl-proline hydroxylation (GO:0019511)2.79261577
48protein localization to endosome (GO:0036010)2.79045791
49negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.78685718
50sarcomere organization (GO:0045214)2.77856864
51adhesion of symbiont to host (GO:0044406)2.77291968
52regulation of glucose import in response to insulin stimulus (GO:2001273)2.75435950
53hypotonic response (GO:0006971)2.75161535
54adhesion of symbiont to host cell (GO:0044650)2.74711310
55virion attachment to host cell (GO:0019062)2.74711310
56semaphorin-plexin signaling pathway (GO:0071526)2.73342365
57modulation by symbiont of host cellular process (GO:0044068)2.73041615
58pentose-phosphate shunt (GO:0006098)2.72402878
59regulation of tight junction assembly (GO:2000810)2.71285352
60skin morphogenesis (GO:0043589)2.71251685
61response to laminar fluid shear stress (GO:0034616)2.68081859
62polarized epithelial cell differentiation (GO:0030859)2.66360245
63positive regulation of protein dephosphorylation (GO:0035307)2.64298870
64regulation of macrophage cytokine production (GO:0010935)2.63185859
65endothelial cell morphogenesis (GO:0001886)2.61904529
66glomerular basement membrane development (GO:0032836)2.61569768
67regulation of mammary gland epithelial cell proliferation (GO:0033599)2.59118824
68regulation of apoptotic process involved in morphogenesis (GO:1902337)2.58544512
69planar cell polarity pathway involved in neural tube closure (GO:0090179)2.58522269
70actin filament bundle assembly (GO:0051017)2.58194349
71actin filament bundle organization (GO:0061572)2.58194349
72endothelial tube morphogenesis (GO:0061154)2.56249428
73morphogenesis of an endothelium (GO:0003159)2.56249428
74endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.55524627
75apoptotic process involved in morphogenesis (GO:0060561)2.55166227
76substrate adhesion-dependent cell spreading (GO:0034446)2.54082719
77focal adhesion assembly (GO:0048041)2.53984000
78cell-substrate adherens junction assembly (GO:0007045)2.53984000
79hyaluronan catabolic process (GO:0030214)2.53243548
80protein hydroxylation (GO:0018126)2.51756013
81activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.49835089
82negative regulation of smooth muscle cell migration (GO:0014912)2.48826205
83membrane raft organization (GO:0031579)2.48743017
84glucose 6-phosphate metabolic process (GO:0051156)2.48711356
85positive regulation of endothelial cell apoptotic process (GO:2000353)2.48676861
86negative regulation of heart growth (GO:0061117)2.43615654
87negative regulation of cardiac muscle tissue growth (GO:0055022)2.43615654
88collagen fibril organization (GO:0030199)2.42692445
89cortical actin cytoskeleton organization (GO:0030866)2.41323787
90endocytic recycling (GO:0032456)2.41018279
91glucose catabolic process (GO:0006007)2.40709518
92anatomical structure regression (GO:0060033)2.39893605
93protein maturation by protein folding (GO:0022417)2.39733309
94fibril organization (GO:0097435)2.38458682
95positive regulation of macrophage cytokine production (GO:0060907)2.38390738
96glomerular filtration (GO:0003094)2.38235793
97carnitine shuttle (GO:0006853)2.37664470
98positive regulation of blood vessel endothelial cell migration (GO:0043536)2.37613107
99positive regulation of lamellipodium assembly (GO:0010592)2.36928394
100endothelial cell chemotaxis (GO:0035767)2.36837113
101embryo implantation (GO:0007566)2.36674374
102modulation by virus of host morphology or physiology (GO:0019048)2.35921941
103regulation of integrin activation (GO:0033623)2.35619952
104cellular response to interferon-alpha (GO:0035457)2.35036969
105positive regulation of nuclease activity (GO:0032075)2.34945647
106cell-cell junction maintenance (GO:0045217)2.33427174
107collagen metabolic process (GO:0032963)2.33303637
108positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.33289683
109regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.32240073
110regulation of fatty acid beta-oxidation (GO:0031998)2.31990050
111regulation of extracellular matrix organization (GO:1903053)2.31909915
112barbed-end actin filament capping (GO:0051016)2.31723800
113negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.31641434
114fatty acid transmembrane transport (GO:1902001)2.31380171
115wound healing, spreading of epidermal cells (GO:0035313)2.31238431
116regulation of hippo signaling (GO:0035330)2.31185693
117cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.31155500
118regulation of membrane protein ectodomain proteolysis (GO:0051043)2.31141460
119* extracellular matrix disassembly (GO:0022617)2.30930563
120modulation by virus of host process (GO:0019054)2.30835556
121hippo signaling (GO:0035329)2.30587446
122endocardial cushion development (GO:0003197)2.28191679
123actin filament depolymerization (GO:0030042)2.27363107
124positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.27316451
125response to peptidoglycan (GO:0032494)2.27276356
126protein targeting to plasma membrane (GO:0072661)2.27229202
127response to fluid shear stress (GO:0034405)2.27213353
128maternal placenta development (GO:0001893)2.27129232
129NLS-bearing protein import into nucleus (GO:0006607)2.27006151
130proline biosynthetic process (GO:0006561)2.26954303
131negative regulation of protein localization to plasma membrane (GO:1903077)2.26171520
132collagen catabolic process (GO:0030574)2.26003682
133cell migration involved in sprouting angiogenesis (GO:0002042)2.25532023
134positive regulation of glycogen biosynthetic process (GO:0045725)2.25090010
135positive regulation of protein deacetylation (GO:0090312)2.24808273
136positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.24785878
137branching involved in mammary gland duct morphogenesis (GO:0060444)2.24441773
138embryonic process involved in female pregnancy (GO:0060136)2.24190680
139dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.23320927
140blood vessel endothelial cell migration (GO:0043534)2.23122070
141integrin-mediated signaling pathway (GO:0007229)2.22834896
142glycosphingolipid catabolic process (GO:0046479)2.22623355
143extracellular fibril organization (GO:0043206)2.22566403
144negative regulation of homotypic cell-cell adhesion (GO:0034111)2.22529142
145Rho protein signal transduction (GO:0007266)2.22361869
146endoplasmic reticulum unfolded protein response (GO:0030968)2.22298057
147activation of MAPKKK activity (GO:0000185)2.21738311
148cortical cytoskeleton organization (GO:0030865)2.21205987
149membrane protein ectodomain proteolysis (GO:0006509)2.21011152
150regulation of defense response to virus by virus (GO:0050690)2.20871735
151multicellular organismal macromolecule metabolic process (GO:0044259)2.20827619
152UV protection (GO:0009650)2.20805870
153retina vasculature morphogenesis in camera-type eye (GO:0061299)2.19528024
154platelet degranulation (GO:0002576)2.19267476
155NADPH regeneration (GO:0006740)2.19242955
156positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.18959557
157negative regulation of cell junction assembly (GO:1901889)2.18842478
158negative regulation of adherens junction organization (GO:1903392)2.18842478
159negative regulation of focal adhesion assembly (GO:0051895)2.18842478
160regulation of fatty acid oxidation (GO:0046320)2.17699501
161muscle filament sliding (GO:0030049)2.17676329
162actin-myosin filament sliding (GO:0033275)2.17676329
163vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.16432054

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.07461634
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.62185763
3* RARG_19884340_ChIP-ChIP_MEFs_Mouse3.25996007
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.13139884
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.89239124
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.86841992
7CLOCK_20551151_ChIP-Seq_293T_Human2.49243214
8ELK3_25401928_ChIP-Seq_HUVEC_Human2.30339124
9TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.15636940
10ZNF263_19887448_ChIP-Seq_K562_Human2.14868886
11* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.04206058
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.02503702
13HIF1A_21447827_ChIP-Seq_MCF-7_Human2.00414100
14KDM2B_26808549_Chip-Seq_SUP-B15_Human1.97341260
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.96006008
16KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.90268047
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.87920710
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86529686
19* RACK7_27058665_Chip-Seq_MCF-7_Human1.85681877
20KDM2B_26808549_Chip-Seq_DND41_Human1.80395423
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.78327766
22* LXR_22292898_ChIP-Seq_THP-1_Human1.76022986
23* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.74130128
24BP1_19119308_ChIP-ChIP_Hs578T_Human1.69849398
25ESR1_21235772_ChIP-Seq_MCF-7_Human1.69388745
26TCF7_22412390_ChIP-Seq_EML_Mouse1.66774718
27ATF3_27146783_Chip-Seq_COLON_Human1.65170568
28P300_27058665_Chip-Seq_ZR-75-30cells_Human1.64133909
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61909114
30* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60545747
31SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.59947482
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.59194771
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58592122
34ZFP281_18757296_ChIP-ChIP_E14_Mouse1.58582991
35CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.52054660
36VDR_21846776_ChIP-Seq_THP-1_Human1.51690531
37* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.51497219
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.50397954
39ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.46401610
40* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.46329401
41SRY_22984422_ChIP-ChIP_TESTIS_Rat1.46207444
42* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44932199
43* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.44463669
44* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44252699
45TET1_21451524_ChIP-Seq_MESCs_Mouse1.43981690
46CTCF_27219007_Chip-Seq_ERYTHROID_Human1.41741565
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.41473963
48* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.40276287
49* TBX20_22328084_ChIP-Seq_HEART_Mouse1.39185702
50* TBX20_22080862_ChIP-Seq_HEART_Mouse1.39185702
51* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.38953835
52* MYC_22102868_ChIP-Seq_BL_Human1.38821570
53FOXO3_23340844_ChIP-Seq_DLD1_Human1.38788667
54SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36324664
55NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35765775
56WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35549427
57* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35072384
58KDM2B_26808549_Chip-Seq_K562_Human1.34748057
59KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.33531909
60KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.33531909
61KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.33531909
62EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.33080325
63TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.32280378
64* SA1_27219007_Chip-Seq_ERYTHROID_Human1.32173872
65ESR1_15608294_ChIP-ChIP_MCF-7_Human1.31892027
66P68_20966046_ChIP-Seq_HELA_Human1.31464307
67MAF_26560356_Chip-Seq_TH1_Human1.30687999
68* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.30366906
69ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.28568718
70* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28408899
71STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.25888856
72BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25661968
73* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25629232
74* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.23362682
75* CREB1_26743006_Chip-Seq_LNCaP_Human1.22802953
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.22733554
77ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22512987
78EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.22159432
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21711505
80* RUNX1_22412390_ChIP-Seq_EML_Mouse1.21459484
81SMC4_20622854_ChIP-Seq_HELA_Human1.21295909
82* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20966348
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19004056
84SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18381677
85NCOR1_26117541_ChIP-Seq_K562_Human1.17927638
86* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17575817
87* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.17268545
88* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.17268545
89VDR_24763502_ChIP-Seq_THP-1_Human1.15271308
90DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15116150
91ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.14123893
92SPI1_23127762_ChIP-Seq_K562_Human1.13894234
93* RUNX1_27514584_Chip-Seq_MCF-7_Human1.12750325
94STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12732852
95* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11800769
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11423334
97KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10808553
98PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10473420
99RXR_22158963_ChIP-Seq_LIVER_Mouse1.10437518
100ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10162881
101ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09947694
102TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09827749
103RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09771973
104* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08737170
105PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08684071
106SMC1_22415368_ChIP-Seq_MEFs_Mouse1.08301363
107* KDM2B_26808549_Chip-Seq_JURKAT_Human1.06955950
108CJUN_26792858_Chip-Seq_BT549_Human1.06540248
109* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.06157412
110GATA6_25053715_ChIP-Seq_YYC3_Human1.05684886
111ESR1_20079471_ChIP-ChIP_T-47D_Human1.05333428
112ELF1_20517297_ChIP-Seq_JURKAT_Human1.04685336
113EP300_21415370_ChIP-Seq_HL-1_Mouse1.04532514
114* TP53_22127205_ChIP-Seq_IMR90_Human1.04491217
115Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04487355
116PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04298547
117SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03805994
118IRF8_27001747_Chip-Seq_BMDM_Mouse1.02858498
119P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02151707
120UBF1/2_26484160_Chip-Seq_HMECs_Human1.02098309
121* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01751402
122* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01457379
123* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01210649
124SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01209044
125E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01187797
126* GATA1_19941827_ChIP-Seq_MEL_Mouse0.98311398
127HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97845550
128MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97792675
129UTX_26944678_Chip-Seq_JUKART_Human0.97486239
130* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96246607
131MAF_26560356_Chip-Seq_TH2_Human0.95375076
132BCOR_27268052_Chip-Seq_Bcells_Human0.92720321

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.16054405
2MP0008438_abnormal_cutaneous_collagen4.04377798
3MP0003566_abnormal_cell_adhesion3.15283349
4MP0005275_abnormal_skin_tensile2.61651608
5MP0005623_abnormal_meninges_morphology2.55827155
6MP0005451_abnormal_body_composition2.45732396
7MP0003300_gastrointestinal_ulcer2.45382282
8MP0004084_abnormal_cardiac_muscle2.43026383
9MP0004272_abnormal_basement_membrane2.42912181
10MP0010352_gastrointestinal_tract_polyps2.34866144
11MP0003279_aneurysm2.30036567
12MP0001958_emphysema2.14343817
13MP0005409_darkened_coat_color2.09809009
14MP0003303_peritoneal_inflammation2.04721718
15MP0005503_abnormal_tendon_morphology2.02557577
16MP0004185_abnormal_adipocyte_glucose1.99113355
17MP0002837_dystrophic_cardiac_calcinosis1.93121434
18MP0004858_abnormal_nervous_system1.83541444
19MP0000751_myopathy1.83451671
20MP0005023_abnormal_wound_healing1.81806617
21MP0002877_abnormal_melanocyte_morpholog1.80972014
22MP0005058_abnormal_lysosome_morphology1.75236537
23MP0010234_abnormal_vibrissa_follicle1.70640169
24MP0008260_abnormal_autophagy1.68482385
25MP0000343_altered_response_to1.62679917
26MP0004130_abnormal_muscle_cell1.62641941
27MP0000750_abnormal_muscle_regeneration1.62612070
28MP0004087_abnormal_muscle_fiber1.61012287
29MP0002796_impaired_skin_barrier1.60822738
30MP0005076_abnormal_cell_differentiation1.59606289
31MP0003045_fibrosis1.56403683
32MP0000733_abnormal_muscle_development1.55261065
33MP0000749_muscle_degeneration1.54696001
34MP0003828_pulmonary_edema1.51692493
35MP0005167_abnormal_blood-brain_barrier1.50463581
36MP0010630_abnormal_cardiac_muscle1.48847648
37MP0003091_abnormal_cell_migration1.48737520
38MP0010368_abnormal_lymphatic_system1.47309097
39MP0004036_abnormal_muscle_relaxation1.46536610
40MP0009278_abnormal_bone_marrow1.44996149
41MP0005666_abnormal_adipose_tissue1.42469540
42MP0001849_ear_inflammation1.37675514
43MP0004947_skin_inflammation1.36652964
44MP0005464_abnormal_platelet_physiology1.31857146
45MP0008775_abnormal_heart_ventricle1.31662942
46MP0003329_amyloid_beta_deposits1.31548142
47MP0000678_abnormal_parathyroid_gland1.30189154
48MP0005501_abnormal_skin_physiology1.24948147
49MP0005330_cardiomyopathy1.24291375
50MP0005257_abnormal_intraocular_pressure1.21103805
51MP0000747_muscle_weakness1.19580852
52MP0006054_spinal_hemorrhage1.19532136
53MP0004510_myositis1.18767416
54MP0004233_abnormal_muscle_weight1.18171835
55MP0005375_adipose_tissue_phenotype1.18028976
56MP0001544_abnormal_cardiovascular_syste1.17472506
57MP0005385_cardiovascular_system_phenoty1.17472506
58MP0003448_altered_tumor_morphology1.13843255
59MP0002972_abnormal_cardiac_muscle1.10697897
60MP0005670_abnormal_white_adipose1.10685424
61MP0000767_abnormal_smooth_muscle1.10032631
62MP0006138_congestive_heart_failure1.08814220
63MP0001542_abnormal_bone_strength1.07500970
64MP0000759_abnormal_skeletal_muscle1.06014639
65MP0009780_abnormal_chondrocyte_physiolo1.04393529
66MP0000858_altered_metastatic_potential1.03742916
67MP0002168_other_aberrant_phenotype1.00923061
68MP0003191_abnormal_cellular_cholesterol1.00431653
69MP0002896_abnormal_bone_mineralization1.00317060
70MP0002269_muscular_atrophy1.00280144
71MP0002089_abnormal_postnatal_growth/wei1.00011361
72MP0005508_abnormal_skeleton_morphology0.99271410
73MP0001533_abnormal_skeleton_physiology0.97635402
74MP0003436_decreased_susceptibility_to0.97431474
75MP0002295_abnormal_pulmonary_circulatio0.96165045
76MP0001879_abnormal_lymphatic_vessel0.93809104
77MP0000604_amyloidosis0.92318880
78* MP0002128_abnormal_blood_circulation0.90034457
79MP0005166_decreased_susceptibility_to0.89631210
80MP0001216_abnormal_epidermal_layer0.88755583
81MP0002060_abnormal_skin_morphology0.88593389
82MP0009384_cardiac_valve_regurgitation0.88278081
83MP0002106_abnormal_muscle_physiology0.87556545
84MP0000249_abnormal_blood_vessel0.86848539
85MP0000003_abnormal_adipose_tissue0.86354358
86* MP0002925_abnormal_cardiovascular_devel0.86143607
87MP0000534_abnormal_ureter_morphology0.85832903
88MP0010030_abnormal_orbit_morphology0.85444785
89MP0003283_abnormal_digestive_organ0.85431635
90MP0002998_abnormal_bone_remodeling0.84326480
91MP0004264_abnormal_extraembryonic_tissu0.83834899
92MP0000467_abnormal_esophagus_morphology0.82915940
93MP0006082_CNS_inflammation0.82732764
94* MP0001614_abnormal_blood_vessel0.82253429
95* MP0000266_abnormal_heart_morphology0.81286815
96MP0010155_abnormal_intestine_physiology0.80893572
97MP0001348_abnormal_lacrimal_gland0.80882792
98MP0002419_abnormal_innate_immunity0.80071017
99MP0005620_abnormal_muscle_contractility0.79521528
100MP0005390_skeleton_phenotype0.78940209
101MP0002108_abnormal_muscle_morphology0.78909980
102MP0005165_increased_susceptibility_to0.78240049
103MP0005369_muscle_phenotype0.77613051
104MP0005621_abnormal_cell_physiology0.77107488
105MP0005367_renal/urinary_system_phenotyp0.75942986
106MP0000516_abnormal_urinary_system0.75942986
107MP0001915_intracranial_hemorrhage0.75704133
108MP0003172_abnormal_lysosome_physiology0.75591847
109MP0001756_abnormal_urination0.75535012
110MP0003453_abnormal_keratinocyte_physiol0.75298021
111MP0003183_abnormal_peptide_metabolism0.75055554
112MP0008961_abnormal_basal_metabolism0.74768762
113MP0009931_abnormal_skin_appearance0.74332887
114MP0001851_eye_inflammation0.74215198
115MP0009840_abnormal_foam_cell0.73679713
116MP0004484_altered_response_of0.73542487
117MP0005164_abnormal_response_to0.73486145
118MP0000681_abnormal_thyroid_gland0.73322203
119MP0009053_abnormal_anal_canal0.72936532
120MP0002249_abnormal_larynx_morphology0.72506478
121MP0003075_altered_response_to0.72398015
122MP0005025_abnormal_response_to0.72235262
123MP0001545_abnormal_hematopoietic_system0.71991329
124MP0005397_hematopoietic_system_phenotyp0.71991329
125MP0003795_abnormal_bone_structure0.71480234
126MP0009333_abnormal_splenocyte_physiolog0.71396848
127MP0000537_abnormal_urethra_morphology0.70848187
128MP0009643_abnormal_urine_homeostasis0.70615988
129MP0004883_abnormal_blood_vessel0.69259022
130MP0000013_abnormal_adipose_tissue0.68677729
131MP0004808_abnormal_hematopoietic_stem0.68326656
132MP0002933_joint_inflammation0.68046354
133MP0005083_abnormal_biliary_tract0.67244763
134MP0003879_abnormal_hair_cell0.66383495
135MP0009115_abnormal_fat_cell0.66352448
136MP0003634_abnormal_glial_cell0.66299601
137MP0001243_abnormal_dermal_layer0.66095306
138MP0003646_muscle_fatigue0.65186482
139MP0010307_abnormal_tumor_latency0.64373505

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.61287359
2Increased connective tissue (HP:0009025)3.81699759
3Premature rupture of membranes (HP:0001788)3.63454815
4Cerebral aneurysm (HP:0004944)3.33017699
5Right ventricular cardiomyopathy (HP:0011663)3.24086867
6Broad metatarsal (HP:0001783)3.22180375
7Ankle contracture (HP:0006466)3.18379863
8Cervical subluxation (HP:0003308)3.10771740
9Hyporeflexia of lower limbs (HP:0002600)3.07857679
10Distal upper limb amyotrophy (HP:0007149)2.95887801
11Upper limb amyotrophy (HP:0009129)2.95887801
12Shallow orbits (HP:0000586)2.91377130
13Hand muscle atrophy (HP:0009130)2.87985726
14Ventricular tachycardia (HP:0004756)2.87712793
15Muscle fiber splitting (HP:0003555)2.87033789
16Atrophic scars (HP:0001075)2.84168440
17Distal lower limb amyotrophy (HP:0008944)2.78612293
18Difficulty climbing stairs (HP:0003551)2.78325097
19Exercise-induced muscle cramps (HP:0003710)2.76540474
20Spinal rigidity (HP:0003306)2.69425213
21Vascular tortuosity (HP:0004948)2.56197830
22Type 1 muscle fiber predominance (HP:0003803)2.55371668
23Sudden death (HP:0001699)2.52699663
24Increased variability in muscle fiber diameter (HP:0003557)2.50070882
25Abnormality of glycolipid metabolism (HP:0010969)2.50050055
26Abnormality of liposaccharide metabolism (HP:0010968)2.50050055
27Abnormality of glycosphingolipid metabolism (HP:0004343)2.50050055
28Obstructive sleep apnea (HP:0002870)2.48835397
29Mitral valve prolapse (HP:0001634)2.48040241
30Arterial tortuosity (HP:0005116)2.46410153
31Asymmetric septal hypertrophy (HP:0001670)2.45532399
32Peritonitis (HP:0002586)2.45227289
33Abnormality of skeletal muscle fiber size (HP:0012084)2.41567133
34Rectal prolapse (HP:0002035)2.40878877
35Aortic aneurysm (HP:0004942)2.40772963
36Flat acetabular roof (HP:0003180)2.38092576
37Enlarged penis (HP:0000040)2.37478011
38Aneurysm (HP:0002617)2.34834922
39Difficulty running (HP:0009046)2.34484166
40Aortic dissection (HP:0002647)2.34291144
41Fragile skin (HP:0001030)2.34140245
42Achilles tendon contracture (HP:0001771)2.32742160
43Osteolytic defects of the hand bones (HP:0009699)2.32005883
44Osteolytic defects of the phalanges of the hand (HP:0009771)2.32005883
45Broad face (HP:0000283)2.31388848
46Mitral regurgitation (HP:0001653)2.30609541
47Nuclear cataract (HP:0100018)2.29748507
48Thin bony cortex (HP:0002753)2.28889336
49Hyperparathyroidism (HP:0000843)2.27205847
50Vertebral compression fractures (HP:0002953)2.27050498
51Increased cerebral lipofuscin (HP:0011813)2.26412452
52Mildly elevated creatine phosphokinase (HP:0008180)2.25869612
53Myoglobinuria (HP:0002913)2.24523287
54Mesangial abnormality (HP:0001966)2.23129104
55Centrally nucleated skeletal muscle fibers (HP:0003687)2.22854104
56EMG: myopathic abnormalities (HP:0003458)2.21607794
57Axonal loss (HP:0003447)2.20690419
58Lymphangioma (HP:0100764)2.15067783
59Distal lower limb muscle weakness (HP:0009053)2.11919167
60Spondylolisthesis (HP:0003302)2.11888402
61Bladder diverticulum (HP:0000015)2.11888187
62Limb-girdle muscle atrophy (HP:0003797)2.10027482
63Abnormality of the Achilles tendon (HP:0005109)2.09330190
64Interstitial pulmonary disease (HP:0006530)2.08281564
65Hematochezia (HP:0002573)2.07728784
66Dilatation of the ascending aorta (HP:0005111)2.05380988
67Hypercortisolism (HP:0001578)2.02010697
68Frequent falls (HP:0002359)2.01782395
69Scapular winging (HP:0003691)2.01069876
70Generalized amyotrophy (HP:0003700)2.00333190
71Urinary glycosaminoglycan excretion (HP:0003541)1.98744105
72Mucopolysacchariduria (HP:0008155)1.98744105
73Neurofibrillary tangles (HP:0002185)1.98459334
74Cerebral inclusion bodies (HP:0100314)1.94606566
75Joint stiffness (HP:0001387)1.93371908
76Blue sclerae (HP:0000592)1.92304559
77J-shaped sella turcica (HP:0002680)1.91098429
78Hemorrhage of the eye (HP:0011885)1.90564174
79Abnormality of the distal phalanges of the toes (HP:0010182)1.90523769
80Elbow flexion contracture (HP:0002987)1.90141921
81Wormian bones (HP:0002645)1.88267625
82Ulnar deviation of the wrist (HP:0003049)1.87562286
83Lower limb amyotrophy (HP:0007210)1.87415765
84Lipoatrophy (HP:0100578)1.87370151
85Genu recurvatum (HP:0002816)1.86860707
86Spinal cord compression (HP:0002176)1.86382219
87Camptodactyly of toe (HP:0001836)1.85840686
88Ulnar bowing (HP:0003031)1.83162136
89Polygenic inheritance (HP:0010982)1.82913205
90Abnormality of the calf musculature (HP:0001430)1.81105336
91Dysostosis multiplex (HP:0000943)1.80906488
92Myotonia (HP:0002486)1.80817477
93Back pain (HP:0003418)1.80725391
94Coxa vara (HP:0002812)1.80627326
95Long palpebral fissure (HP:0000637)1.80135018
96Trismus (HP:0000211)1.79111814
97Supranuclear gaze palsy (HP:0000605)1.78724590
98Striae distensae (HP:0001065)1.78706803
99Abnormality of the acetabulum (HP:0003170)1.77413833
100Purpura (HP:0000979)1.76867424
101Distal arthrogryposis (HP:0005684)1.75205554
102Stridor (HP:0010307)1.74920697
103Radial bowing (HP:0002986)1.74120940
104Systemic lupus erythematosus (HP:0002725)1.72643890
105Increased neuronal autofluorescent lipopigment (HP:0002074)1.72515548
106Biconcave vertebral bodies (HP:0004586)1.72372021
107Calf muscle hypertrophy (HP:0008981)1.71706765
108Buphthalmos (HP:0000557)1.71679310
109Subacute progressive viral hepatitis (HP:0006572)1.71607750
110Abnormality of the nasal mucosa (HP:0000433)1.70674022
111Vertebral hypoplasia (HP:0008417)1.70388366
112Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.70388366
113Osteopenia (HP:0000938)1.70249533
114Insomnia (HP:0100785)1.70122898
115Metaphyseal cupping (HP:0003021)1.69088634
116Bone pain (HP:0002653)1.68821645
117Amyloidosis (HP:0011034)1.68795094
118Eczematoid dermatitis (HP:0000976)1.68031953
119Short nail (HP:0001799)1.67941705
120Growth hormone excess (HP:0000845)1.66938012
121Asymmetry of the thorax (HP:0001555)1.66680777
122Abnormality of dentin (HP:0010299)1.66571379
123Abnormality of the thoracic spine (HP:0100711)1.66387771
124Rapidly progressive (HP:0003678)1.66043921
125Bulbar palsy (HP:0001283)1.65959150
126Loss of speech (HP:0002371)1.65767972
127Emphysema (HP:0002097)1.65754756
128Acanthosis nigricans (HP:0000956)1.65556750
129Ovoid vertebral bodies (HP:0003300)1.65011945
130Hyperextensible skin (HP:0000974)1.64091515
131Abnormality of mucopolysaccharide metabolism (HP:0011020)1.63128525
132Abnormality of polysaccharide metabolism (HP:0011012)1.63128525
133Abnormality of glycosaminoglycan metabolism (HP:0004371)1.63128525
134Facial diplegia (HP:0001349)1.63029687
135Multiple enchondromatosis (HP:0005701)1.62950390
136Esophageal varix (HP:0002040)1.62314270
137Beaking of vertebral bodies (HP:0004568)1.61912380
138Hyperacusis (HP:0010780)1.61070112
139Slender build (HP:0001533)1.60872909
140Disproportionate tall stature (HP:0001519)1.59585882
141Subaortic stenosis (HP:0001682)1.59301002

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.32204462
2PKN23.73150141
3ERN13.46037932
4TTN3.17017034
5IRAK32.75025824
6PRPF4B2.70551540
7SMG12.62554961
8RIPK12.26612643
9EPHB12.05055713
10EEF2K1.96454122
11LRRK21.94762040
12NEK91.81910780
13PDGFRA1.73089133
14BMX1.72972078
15LMTK21.60811393
16DMPK1.59618447
17PTK61.57863144
18PAK41.55892374
19KSR21.51664349
20EPHA21.50918255
21CDK121.46932695
22TAOK21.43749006
23ARAF1.42426720
24MET1.35479437
25MST1R1.34085017
26SIK11.33524538
27MAP3K21.33162811
28PTK21.30362656
29TGFBR21.28516312
30NME21.25850351
31RET1.25673667
32RIPK41.20857965
33DDR21.20856546
34MAP2K31.19992009
35TESK11.19989740
36ILK1.19793150
37CAMK1D1.19724247
38CDC42BPA1.18626991
39PRKD21.16939153
40MYLK1.14189501
41MAP3K131.14095987
42MOS1.10855199
43EPHA31.10849777
44PRKG21.08702565
45MAP2K21.07663960
46PTK2B1.05183128
47EPHB21.03704800
48FER1.03314254
49NEK11.03213449
50TESK20.99652841
51NTRK10.97378820
52CAMK1G0.93295478
53MATK0.93293781
54FLT30.93181615
55LATS10.92719208
56PIM20.91293951
57MARK20.89629467
58LATS20.89564994
59STK100.89396954
60TIE10.86740437
61WNK10.86380032
62MAP3K100.84036729
63MAP3K10.83798467
64PDK20.83168227
65MAPKAPK30.82748136
66MTOR0.82017370
67TGFBR10.81576403
68ALK0.81255347
69PAK20.80400321
70STK380.78338516
71PDK40.77541990
72PDK30.77541990
73SCYL20.76905804
74TRPM70.76387611
75FGFR40.76091419
76MAP3K30.76052883
77TBK10.75603838
78PRKD30.75542181
79TYK20.75438093
80FGFR30.74754808
81SIK30.73179979
82MAP2K10.72309027
83CDK60.72022165
84PIK3CA0.71697236
85WNK40.71054346
86MAP4K10.70815071
87BRAF0.70325134
88HIPK20.69847316
89TAOK10.68529379
90MAP3K60.67163355
91PRKD10.64468635
92PDGFRB0.64158025
93RPS6KA20.64048429
94ZAP700.62672690
95MAP3K110.62435174
96LIMK10.62302933
97DAPK30.61562355
98IRAK40.59845141
99IRAK20.58046898
100KDR0.58028436
101CSK0.57868156
102ABL20.56647670
103PDK10.54827476
104RPS6KA40.54825854
105PRKCH0.54803403
106MAP3K90.52563652
107STK30.52509675
108JAK10.51664031
109MAP3K80.51160792
110MAP3K140.50572458
111RPS6KB20.50146406
112STK240.50002899
113ICK0.49645493
114JAK20.46038302
115PAK10.45448480
116ROCK20.43556357
117ROCK10.43343293
118PHKG20.42476823
119PHKG10.42476823
120MAPK110.41722934
121JAK30.41682996
122PDPK10.41161232
123MAPKAPK20.40811585
124BLK0.40425054
125RPS6KL10.40234726
126RPS6KC10.40234726
127MAPK120.39352916
128CAMKK10.38021068
129SGK30.36911916
130CDK90.34923004
131PAK60.32622839
132MAPK70.31838382

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.15311558
2Focal adhesion_Homo sapiens_hsa045102.00456309
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.95858343
4Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.91201122
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.74838971
6Amoebiasis_Homo sapiens_hsa051461.65255093
7AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.63732652
8Proteoglycans in cancer_Homo sapiens_hsa052051.63616392
9Dilated cardiomyopathy_Homo sapiens_hsa054141.62866233
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.57163891
11Adherens junction_Homo sapiens_hsa045201.56005908
12Chronic myeloid leukemia_Homo sapiens_hsa052201.55737008
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52009659
14Pentose phosphate pathway_Homo sapiens_hsa000301.51028882
15Bladder cancer_Homo sapiens_hsa052191.49865508
16Viral myocarditis_Homo sapiens_hsa054161.49848287
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.46030891
18Leukocyte transendothelial migration_Homo sapiens_hsa046701.43508059
19Toxoplasmosis_Homo sapiens_hsa051451.41179343
20Lysosome_Homo sapiens_hsa041421.39887862
21Central carbon metabolism in cancer_Homo sapiens_hsa052301.39557975
22Notch signaling pathway_Homo sapiens_hsa043301.35731347
23Nitrogen metabolism_Homo sapiens_hsa009101.33948602
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.32254351
25Insulin resistance_Homo sapiens_hsa049311.27762723
26Leishmaniasis_Homo sapiens_hsa051401.26379478
27Thyroid cancer_Homo sapiens_hsa052161.24342731
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.22046998
29Small cell lung cancer_Homo sapiens_hsa052221.21270200
30HIF-1 signaling pathway_Homo sapiens_hsa040661.20206601
31Platelet activation_Homo sapiens_hsa046111.19621673
32Vibrio cholerae infection_Homo sapiens_hsa051101.18905852
33Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18377532
34Regulation of actin cytoskeleton_Homo sapiens_hsa048101.16420496
35Acute myeloid leukemia_Homo sapiens_hsa052211.12127738
36Adipocytokine signaling pathway_Homo sapiens_hsa049201.11216594
37Neurotrophin signaling pathway_Homo sapiens_hsa047221.08855629
38VEGF signaling pathway_Homo sapiens_hsa043701.08430709
39Dorso-ventral axis formation_Homo sapiens_hsa043201.08203167
40Salmonella infection_Homo sapiens_hsa051321.07165283
41Osteoclast differentiation_Homo sapiens_hsa043801.05475210
42Hepatitis C_Homo sapiens_hsa051601.03971441
43Other glycan degradation_Homo sapiens_hsa005111.02721798
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02399613
45Pancreatic cancer_Homo sapiens_hsa052121.01373540
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01295419
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00464162
48Shigellosis_Homo sapiens_hsa051310.99435971
49Carbon metabolism_Homo sapiens_hsa012000.99353522
50GnRH signaling pathway_Homo sapiens_hsa049120.98326965
51ErbB signaling pathway_Homo sapiens_hsa040120.97533559
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97102026
53Insulin signaling pathway_Homo sapiens_hsa049100.96924625
54Protein digestion and absorption_Homo sapiens_hsa049740.96894713
55Tight junction_Homo sapiens_hsa045300.96285332
56Galactose metabolism_Homo sapiens_hsa000520.95759463
57Glioma_Homo sapiens_hsa052140.94224401
58PPAR signaling pathway_Homo sapiens_hsa033200.93646316
59Renal cell carcinoma_Homo sapiens_hsa052110.93558999
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91746113
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91285419
62mTOR signaling pathway_Homo sapiens_hsa041500.90902888
63Pertussis_Homo sapiens_hsa051330.90867930
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87669493
65Endometrial cancer_Homo sapiens_hsa052130.85915573
66Apoptosis_Homo sapiens_hsa042100.85833558
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.84584215
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.83708911
69Fatty acid degradation_Homo sapiens_hsa000710.83577188
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82502181
71Malaria_Homo sapiens_hsa051440.81930974
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81204558
73Tuberculosis_Homo sapiens_hsa051520.80666418
74Hepatitis B_Homo sapiens_hsa051610.80544575
75Melanoma_Homo sapiens_hsa052180.79930205
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78581981
77AMPK signaling pathway_Homo sapiens_hsa041520.76818086
78Non-small cell lung cancer_Homo sapiens_hsa052230.76569501
79TGF-beta signaling pathway_Homo sapiens_hsa043500.76371138
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75612117
81PI3K-Akt signaling pathway_Homo sapiens_hsa041510.75392511
82Influenza A_Homo sapiens_hsa051640.73765514
83B cell receptor signaling pathway_Homo sapiens_hsa046620.72529740
84Estrogen signaling pathway_Homo sapiens_hsa049150.72128480
85Prolactin signaling pathway_Homo sapiens_hsa049170.71979250
86Choline metabolism in cancer_Homo sapiens_hsa052310.70351211
87Hippo signaling pathway_Homo sapiens_hsa043900.70240871
88Endocytosis_Homo sapiens_hsa041440.70170633
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69920831
90Pathways in cancer_Homo sapiens_hsa052000.69127255
91Phagosome_Homo sapiens_hsa041450.67848721
92Prostate cancer_Homo sapiens_hsa052150.67731974
93Rap1 signaling pathway_Homo sapiens_hsa040150.67529150
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67234232
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67050328
96TNF signaling pathway_Homo sapiens_hsa046680.66442962
97Legionellosis_Homo sapiens_hsa051340.65979112
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65583721
99Staphylococcus aureus infection_Homo sapiens_hsa051500.65430702
100Starch and sucrose metabolism_Homo sapiens_hsa005000.62894495
101Long-term potentiation_Homo sapiens_hsa047200.62529592
102MicroRNAs in cancer_Homo sapiens_hsa052060.61389324
103Fatty acid metabolism_Homo sapiens_hsa012120.60338714
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59805182
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59528535
106Fructose and mannose metabolism_Homo sapiens_hsa000510.59235492
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59113350
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58715243
109Phenylalanine metabolism_Homo sapiens_hsa003600.58577476
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58471801
111HTLV-I infection_Homo sapiens_hsa051660.58138701
112Chemokine signaling pathway_Homo sapiens_hsa040620.57930963
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57692948
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57398965
115Thyroid hormone synthesis_Homo sapiens_hsa049180.56129706
116Bile secretion_Homo sapiens_hsa049760.56023688
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55814203
118Prion diseases_Homo sapiens_hsa050200.55567381
119Mineral absorption_Homo sapiens_hsa049780.55494547
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55094053
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54657504
122Colorectal cancer_Homo sapiens_hsa052100.54231370
123Gap junction_Homo sapiens_hsa045400.54144696
124Inositol phosphate metabolism_Homo sapiens_hsa005620.52746389
125Biosynthesis of amino acids_Homo sapiens_hsa012300.52632320
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.52615036
127Melanogenesis_Homo sapiens_hsa049160.48534746

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