CAPN9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.73634446
2epithelial cilium movement (GO:0003351)9.40887007
3epithelial structure maintenance (GO:0010669)8.44801959
4bundle of His cell to Purkinje myocyte communication (GO:0086069)7.40756235
5primary alcohol catabolic process (GO:0034310)7.33508495
6vitamin transmembrane transport (GO:0035461)7.01473964
7axoneme assembly (GO:0035082)6.85529094
8intestinal absorption (GO:0050892)6.53133905
9ethanol metabolic process (GO:0006067)6.49983786
10left/right pattern formation (GO:0060972)6.33880296
11digestive system process (GO:0022600)6.28419830
12sulfation (GO:0051923)6.23653522
13* digestion (GO:0007586)6.02839870
14O-glycan processing (GO:0016266)5.96243872
15intestinal epithelial cell development (GO:0060576)5.73324996
16ethanol oxidation (GO:0006069)5.71630545
17diterpenoid biosynthetic process (GO:0016102)5.66553257
18desmosome organization (GO:0002934)5.43044458
19glandular epithelial cell differentiation (GO:0002067)5.27742568
203-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.17873548
21purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.17873548
22regulation of cilium movement (GO:0003352)5.09046869
23sperm capacitation (GO:0048240)4.87704167
24regulation of proton transport (GO:0010155)4.74043480
25left/right axis specification (GO:0070986)4.67822745
26negative regulation of digestive system process (GO:0060457)4.63317348
27ventricular system development (GO:0021591)4.60250802
28lung epithelium development (GO:0060428)4.55826070
29regulation of phospholipase A2 activity (GO:0032429)4.49149917
30phosphatidylserine acyl-chain remodeling (GO:0036150)4.38076829
31oligosaccharide biosynthetic process (GO:0009312)4.33151072
32actin filament depolymerization (GO:0030042)4.31210938
33one-carbon compound transport (GO:0019755)4.29825757
34UDP-N-acetylglucosamine metabolic process (GO:0006047)4.26522555
35phosphatidylinositol acyl-chain remodeling (GO:0036149)4.24633764
36protein O-linked glycosylation (GO:0006493)4.21501920
37microtubule bundle formation (GO:0001578)4.17992742
38lung secretory cell differentiation (GO:0061140)4.13972220
39intestinal cholesterol absorption (GO:0030299)4.02217279
40epoxygenase P450 pathway (GO:0019373)3.98186180
41intraciliary transport (GO:0042073)3.90527665
42glutathione derivative biosynthetic process (GO:1901687)3.88904103
43glutathione derivative metabolic process (GO:1901685)3.88904103
44terpenoid biosynthetic process (GO:0016114)3.87174893
45exogenous drug catabolic process (GO:0042738)3.87088016
46protein autoprocessing (GO:0016540)3.85334344
47regulation of water loss via skin (GO:0033561)3.84026007
48primary alcohol metabolic process (GO:0034308)3.82797262
49ventricular cardiac muscle cell action potential (GO:0086005)3.82159858
50retinoic acid metabolic process (GO:0042573)3.81138500
51regulation of pH (GO:0006885)3.80686902
52phospholipid scrambling (GO:0017121)3.77933084
53thyroid hormone metabolic process (GO:0042403)3.72477452
54sphingoid metabolic process (GO:0046519)3.71669222
55phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.70181149
56cilium organization (GO:0044782)3.65539268
57phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.63234800
58establishment of skin barrier (GO:0061436)3.61170129
59sodium ion homeostasis (GO:0055078)3.55382387
60cilium assembly (GO:0042384)3.54859583
61negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.53358162
62negative regulation of T cell differentiation in thymus (GO:0033085)3.50962619
63retinol metabolic process (GO:0042572)3.48660069
64establishment of apical/basal cell polarity (GO:0035089)3.46703792
65drug catabolic process (GO:0042737)3.45948569
66excretion (GO:0007588)3.45423843
67angiotensin maturation (GO:0002003)3.44937390
68phosphatidylserine metabolic process (GO:0006658)3.43664667
69regulation of guanylate cyclase activity (GO:0031282)3.43004821
70sulfate transmembrane transport (GO:1902358)3.38550923
71keratinocyte proliferation (GO:0043616)3.34706736
72bile acid and bile salt transport (GO:0015721)3.31639956
73water homeostasis (GO:0030104)3.30286055
74phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.26099940
75regulation of interleukin-5 production (GO:0032674)3.24594371
76cell communication involved in cardiac conduction (GO:0086065)3.24441549
77extracellular fibril organization (GO:0043206)3.24009926
78diol metabolic process (GO:0034311)3.23186447
79regulation of transforming growth factor beta1 production (GO:0032908)3.20437313
80bicarbonate transport (GO:0015701)3.20190191
81response to xenobiotic stimulus (GO:0009410)3.20125323
82glomerular epithelial cell development (GO:0072310)3.19839223
83regulation of heart rate by cardiac conduction (GO:0086091)3.15576150
84fucose catabolic process (GO:0019317)3.14221925
85L-fucose metabolic process (GO:0042354)3.14221925
86L-fucose catabolic process (GO:0042355)3.14221925
87drug metabolic process (GO:0017144)3.13824235
88sulfur amino acid catabolic process (GO:0000098)3.12362975
89regulation of interleukin-13 production (GO:0032656)3.11471609
90negative regulation of humoral immune response (GO:0002921)3.09076467
91cellular glucuronidation (GO:0052695)3.08928220
92cardiac conduction (GO:0061337)3.05386766
93phenol-containing compound catabolic process (GO:0019336)3.04291273
94flavonoid metabolic process (GO:0009812)3.02392456
95glucuronate metabolic process (GO:0019585)3.01974215
96uronic acid metabolic process (GO:0006063)3.01974215
97sulfur compound transport (GO:0072348)3.01103845
98sphingomyelin metabolic process (GO:0006684)3.00109332
99lipoprotein transport (GO:0042953)2.99659507
100renal absorption (GO:0070293)2.97786309
101nucleotide-sugar biosynthetic process (GO:0009226)2.97013154
102icosanoid secretion (GO:0032309)2.92818855
103arachidonic acid secretion (GO:0050482)2.92818855
104diacylglycerol metabolic process (GO:0046339)2.92008373
105sphingosine metabolic process (GO:0006670)2.91529096
106microtubule-based movement (GO:0007018)2.90181694
107establishment of monopolar cell polarity (GO:0061162)2.89413982
108establishment or maintenance of monopolar cell polarity (GO:0061339)2.89413982
109NADH metabolic process (GO:0006734)2.89408938
110growth hormone secretion (GO:0030252)2.88813962
111regulation of microtubule-based movement (GO:0060632)2.87195378
112vitamin A metabolic process (GO:0006776)2.87155505
113regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.86466652
114tolerance induction (GO:0002507)2.86211704
115mucosal immune response (GO:0002385)2.86077462
116carnitine metabolic process (GO:0009437)2.84923676
117cell projection assembly (GO:0030031)2.84612826
118leukotriene biosynthetic process (GO:0019370)2.84112474
119alditol phosphate metabolic process (GO:0052646)2.81387111
120fatty acid derivative transport (GO:1901571)2.81097886
121icosanoid transport (GO:0071715)2.81097886
122phosphatidylcholine biosynthetic process (GO:0006656)2.80907440
123adhesion of symbiont to host cell (GO:0044650)2.80802054
124virion attachment to host cell (GO:0019062)2.80802054
125amyloid precursor protein catabolic process (GO:0042987)2.80627757
126multicellular organismal water homeostasis (GO:0050891)2.80261093
127kidney morphogenesis (GO:0060993)2.78689365
128cellular component assembly involved in morphogenesis (GO:0010927)2.78676901
129receptor guanylyl cyclase signaling pathway (GO:0007168)2.78397454
130centriole assembly (GO:0098534)2.77622856
131peptide hormone processing (GO:0016486)2.76327651
132thrombin receptor signaling pathway (GO:0070493)2.75721728
133regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.75570256
134monovalent inorganic cation homeostasis (GO:0055067)2.75152351
135carnitine transport (GO:0015879)2.74364708
136amino-acid betaine transport (GO:0015838)2.74364708
137positive regulation of smoothened signaling pathway (GO:0045880)2.73546347
138antibacterial humoral response (GO:0019731)2.72505666
139carnitine transmembrane transport (GO:1902603)2.71877355
140progesterone metabolic process (GO:0042448)2.71643263
141phosphatidylcholine acyl-chain remodeling (GO:0036151)2.71422110
142transcytosis (GO:0045056)2.71342900
143leukotriene metabolic process (GO:0006691)2.69501975
144neurotransmitter biosynthetic process (GO:0042136)2.69076352
145galactose catabolic process (GO:0019388)2.68626006
146glutathione biosynthetic process (GO:0006750)2.68558042
147negative regulation of immunoglobulin mediated immune response (GO:0002890)2.68014738
148negative regulation of B cell mediated immunity (GO:0002713)2.68014738
149thyroid hormone generation (GO:0006590)2.67907497
150potassium ion export (GO:0071435)2.67893060
151fibril organization (GO:0097435)2.67763901
152organ or tissue specific immune response (GO:0002251)2.66785574
153nucleotide-sugar metabolic process (GO:0009225)2.66683265
154adenosine metabolic process (GO:0046085)2.66069172
155regulation of viral release from host cell (GO:1902186)2.65806645
156drinking behavior (GO:0042756)2.64954891
157protein retention in ER lumen (GO:0006621)2.63687174
158GDP-mannose metabolic process (GO:0019673)2.63074856
159positive regulation of tolerance induction (GO:0002645)2.62756539
160protein localization to cilium (GO:0061512)2.62707394
161establishment of planar polarity (GO:0001736)2.61897055
162establishment of tissue polarity (GO:0007164)2.61897055
163pyrimidine-containing compound transmembrane transport (GO:0072531)2.61718743
164antimicrobial humoral response (GO:0019730)2.61555499
165membrane repolarization during action potential (GO:0086011)2.60200799
166sulfate transport (GO:0008272)2.57467812
167innate immune response in mucosa (GO:0002227)2.56724783
168acid secretion (GO:0046717)2.56505103
169membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.55574939
170calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.54959545
171maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.51018423
172glutathione metabolic process (GO:0006749)2.50498951
173membrane budding (GO:0006900)2.50139864
174hemidesmosome assembly (GO:0031581)2.49443311
175regulation of digestive system process (GO:0044058)2.48744223
176axonemal dynein complex assembly (GO:0070286)15.5212400
177cilium or flagellum-dependent cell motility (GO:0001539)12.6813745
178maintenance of gastrointestinal epithelium (GO:0030277)11.1159481
179cilium movement (GO:0003341)11.0123521
180motile cilium assembly (GO:0044458)10.2430580

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.71660491
2SOX2_27498859_Chip-Seq_STOMACH_Mouse4.09920217
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.90219859
4CDX2_20551321_ChIP-Seq_CACO-2_Human3.09237478
5ESR2_21235772_ChIP-Seq_MCF-7_Human3.05103723
6GATA4_25053715_ChIP-Seq_YYC3_Human2.96403904
7VDR_22108803_ChIP-Seq_LS180_Human2.95829271
8SOX2_20726797_ChIP-Seq_SW620_Human2.94526863
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.63444616
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.46239612
11GATA6_25053715_ChIP-Seq_YYC3_Human2.36522676
12TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.27420034
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.12324488
14SRY_22984422_ChIP-ChIP_TESTIS_Rat2.06007719
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03276276
16PPAR_26484153_Chip-Seq_NCI-H1993_Human1.94982682
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.86756988
18KLF5_25053715_ChIP-Seq_YYC3_Human1.86455230
19CDX2_19796622_ChIP-Seq_MESCs_Mouse1.85927558
20ZNF217_24962896_ChIP-Seq_MCF-7_Human1.84387784
21ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.72601420
22FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.68339392
23FOXO3_23340844_ChIP-Seq_DLD1_Human1.66924728
24ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.66012339
25AHR_22903824_ChIP-Seq_MCF-7_Human1.63414606
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61174011
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.59753732
28EGR1_19032775_ChIP-ChIP_M12_Human1.54117464
29RUNX1_27514584_Chip-Seq_MCF-7_Human1.53903105
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.50567505
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.48547307
32PPARA_22158963_ChIP-Seq_LIVER_Mouse1.44675038
33ESR1_15608294_ChIP-ChIP_MCF-7_Human1.39235528
34P63_26484246_Chip-Seq_KERATINOCYTES_Human1.38501249
35GATA3_24758297_ChIP-Seq_MCF-7_Human1.38231502
36SMC4_20622854_ChIP-Seq_HELA_Human1.36486861
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.35640768
38HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.35279952
39ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.34326869
40CTNNB1_20460455_ChIP-Seq_HCT116_Human1.33446418
41LXR_22158963_ChIP-Seq_LIVER_Mouse1.32999355
42* TCF4_18268006_ChIP-ChIP_LS174T_Human1.28956935
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.28688041
44* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28109888
45RACK7_27058665_Chip-Seq_MCF-7_Human1.25847345
46HIF1A_21447827_ChIP-Seq_MCF-7_Human1.24996850
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.23540332
48RXR_22108803_ChIP-Seq_LS180_Human1.23276847
49CLOCK_20551151_ChIP-Seq_293T_Human1.22700688
50FOXA1_25552417_ChIP-Seq_VCAP_Human1.22404691
51AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.22328962
52ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21117006
53TDRD3_21172665_ChIP-Seq_MCF-7_Human1.19799097
54KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17332579
55* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17149290
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.16422888
57* CREB1_26743006_Chip-Seq_LNCaP_Human1.16361235
58* BCAT_22108803_ChIP-Seq_LS180_Human1.15595135
59RXR_22158963_ChIP-Seq_LIVER_Mouse1.14672349
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14169472
61SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13699844
62CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13413290
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12943531
64SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12475037
65SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12475037
66CJUN_26792858_Chip-Seq_BT549_Human1.11630299
67BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11281503
68* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10831959
69SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10723748
70EP300_21415370_ChIP-Seq_HL-1_Mouse1.08283235
71GATA1_19941826_ChIP-Seq_K562_Human1.05397448
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03490541
73SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.02922837
74JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02781836
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02694964
76FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.01345127
77* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99695160
78PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99077327
79CTCF_20526341_ChIP-Seq_ESCs_Human0.97834443
80BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.97034231
81SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96601828
82ARNT_22903824_ChIP-Seq_MCF-7_Human0.95999739
83LXR_22292898_ChIP-Seq_THP-1_Human0.95267858
84* CEBPB_22108803_ChIP-Seq_LS180_Human0.93393685
85EZH2_27294783_Chip-Seq_ESCs_Mouse0.92397710
86STAT1_20625510_ChIP-Seq_HELA_Human0.92106836
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92078490
88CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.91934646
89P68_20966046_ChIP-Seq_HELA_Human0.89859612
90EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89540872
91FOXA2_19822575_ChIP-Seq_HepG2_Human0.87236873
92DROSHA_22980978_ChIP-Seq_HELA_Human0.87174873
93SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86692763
94TP63_23658742_ChIP-Seq_EP156T_Human0.86487222
95JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86154099
96PHF8_20622854_ChIP-Seq_HELA_Human0.86138180
97CTCF_27219007_Chip-Seq_Bcells_Human0.85995718
98SOX2_21211035_ChIP-Seq_LN229_Human0.85970742
99* HNF4A_19822575_ChIP-Seq_HepG2_Human0.83268420
100NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.81953032
101MYC_27129775_Chip-Seq_CORNEA_Mouse0.81868960
102SMAD3_21741376_ChIP-Seq_HESCs_Human0.81703596
103ZNF263_19887448_ChIP-Seq_K562_Human0.81368489
104SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.81012253
105KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.80663385
106* SA1_27219007_Chip-Seq_Bcells_Human0.80181885
107GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80176947
108PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.80106413
109MTF2_20144788_ChIP-Seq_MESCs_Mouse0.80010181
110* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.79954977
111* HNFA_21074721_ChIP-Seq_CACO-2_Human0.79744640
112GATA2_19941826_ChIP-Seq_K562_Human0.78816781
113BCOR_27268052_Chip-Seq_Bcells_Human0.78744270
114THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78242130
115* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.77937774
116TP63_22573176_ChIP-Seq_HFKS_Human0.77770246
117ERG_21242973_ChIP-ChIP_JURKAT_Human0.77294390
118KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.77242730
119KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.77242730
120KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.77242730
121EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.76942202
122JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.76908213
123MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.76096566
124* CDX2_22108803_ChIP-Seq_LS180_Human0.75703409
125YY1_22570637_ChIP-Seq_MALME-3M_Human0.75499973
126* TBX20_22328084_ChIP-Seq_HEART_Mouse0.75348898
127* TBX20_22080862_ChIP-Seq_HEART_Mouse0.75348898
128TP53_18474530_ChIP-ChIP_U2OS_Human0.75227817
129E2F1_20622854_ChIP-Seq_HELA_Human0.75088233
130* ETV1_20927104_ChIP-Seq_GIST48_Human0.74598451
131SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.74415416
132RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.73454311
133CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.73304295
134* ATF3_27146783_Chip-Seq_COLON_Human0.73002956
135BMI1_23680149_ChIP-Seq_NPCS_Mouse0.72332639
136* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.71806124

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.12169235
2MP0001664_abnormal_digestion4.31789163
3MP0001873_stomach_inflammation4.28288764
4MP0001666_abnormal_nutrient_absorption4.01031317
5MP0000566_synostosis3.30015728
6MP0002653_abnormal_ependyma_morphology3.28639177
7MP0002132_abnormal_respiratory_system3.02138452
8MP0000470_abnormal_stomach_morphology2.82629420
9MP0005360_urolithiasis2.74236875
10MP0003806_abnormal_nucleotide_metabolis2.65178971
11MP0004264_abnormal_extraembryonic_tissu2.63188843
12MP0002796_impaired_skin_barrier2.55983254
13MP0001663_abnormal_digestive_system2.55195462
14MP0005381_digestive/alimentary_phenotyp2.40318151
15MP0000462_abnormal_digestive_system2.35712435
16MP0003866_abnormal_defecation2.28081702
17MP0008004_abnormal_stomach_pH11.4352002
18MP0000383_abnormal_hair_follicle1.99631544
19MP0000678_abnormal_parathyroid_gland1.93223611
20MP0003868_abnormal_feces_composition1.91211236
21MP0004270_analgesia1.85705660
22MP0004147_increased_porphyrin_level1.85429643
23MP0005409_darkened_coat_color1.82922115
24MP0004043_abnormal_pH_regulation1.81921971
25MP0000477_abnormal_intestine_morphology1.79912959
26MP0006054_spinal_hemorrhage1.79607202
27MP0005085_abnormal_gallbladder_physiolo1.72352659
28MP0008789_abnormal_olfactory_epithelium1.69909474
29MP0001984_abnormal_olfaction1.67684312
30MP0003183_abnormal_peptide_metabolism1.63821600
31MP0010155_abnormal_intestine_physiology1.59403113
32MP0005501_abnormal_skin_physiology1.56051989
33MP0003283_abnormal_digestive_organ1.54294780
34MP0008875_abnormal_xenobiotic_pharmacok1.53504369
35MP0001986_abnormal_taste_sensitivity1.52184608
36MP0004782_abnormal_surfactant_physiolog1.44652372
37MP0000013_abnormal_adipose_tissue1.38352139
38MP0004858_abnormal_nervous_system1.38194108
39MP0003252_abnormal_bile_duct1.33482431
40MP0000490_abnormal_crypts_of1.31599174
41MP0002249_abnormal_larynx_morphology1.28587414
42MP0002735_abnormal_chemical_nociception1.27615515
43MP0004133_heterotaxia1.25828507
44MP0005365_abnormal_bile_salt1.25355815
45MP0005451_abnormal_body_composition1.24409250
46MP0000537_abnormal_urethra_morphology1.24326666
47MP0000538_abnormal_urinary_bladder1.21933651
48MP0000467_abnormal_esophagus_morphology1.20722101
49MP0001968_abnormal_touch/_nociception1.20625269
50MP0002136_abnormal_kidney_physiology1.19439595
51MP0001346_abnormal_lacrimal_gland1.19021362
52MP0005408_hypopigmentation1.18464199
53MP0001765_abnormal_ion_homeostasis1.18229200
54MP0010678_abnormal_skin_adnexa1.17935542
55MP0010352_gastrointestinal_tract_polyps1.17675794
56MP0002733_abnormal_thermal_nociception1.14786563
57MP0005275_abnormal_skin_tensile1.11577005
58MP0003705_abnormal_hypodermis_morpholog1.10720624
59MP0002876_abnormal_thyroid_physiology1.08879277
60MP0010771_integument_phenotype1.08407330
61MP0010386_abnormal_urinary_bladder1.07476471
62MP0010329_abnormal_lipoprotein_level1.05861402
63MP0004185_abnormal_adipocyte_glucose1.05035618
64MP0002282_abnormal_trachea_morphology1.02819769
65MP0002168_other_aberrant_phenotype1.01425715
66MP0001485_abnormal_pinna_reflex1.01048698
67MP0001216_abnormal_epidermal_layer0.99763096
68MP0005499_abnormal_olfactory_system0.97270873
69MP0005394_taste/olfaction_phenotype0.97270873
70MP0003453_abnormal_keratinocyte_physiol0.96925146
71MP0005636_abnormal_mineral_homeostasis0.96171150
72MP0002909_abnormal_adrenal_gland0.94325087
73MP0002098_abnormal_vibrissa_morphology0.93920586
74MP0003941_abnormal_skin_development0.93666360
75MP0005248_abnormal_Harderian_gland0.92816487
76MP0002009_preneoplasia0.91607322
77MP0004019_abnormal_vitamin_homeostasis0.91219253
78MP0000465_gastrointestinal_hemorrhage0.90834418
79MP0009780_abnormal_chondrocyte_physiolo0.90703697
80MP0005448_abnormal_energy_balance0.90242341
81MP0002736_abnormal_nociception_after0.90101210
82MP0004947_skin_inflammation0.89173937
83MP0000427_abnormal_hair_cycle0.88661367
84MP0009384_cardiac_valve_regurgitation0.88212660
85MP0005083_abnormal_biliary_tract0.86574776
86* MP0005165_increased_susceptibility_to0.85852216
87MP0002060_abnormal_skin_morphology0.85444387
88MP0002277_abnormal_respiratory_mucosa0.84198711
89MP0000681_abnormal_thyroid_gland0.83061429
90MP0010030_abnormal_orbit_morphology0.82042396
91MP0005623_abnormal_meninges_morphology0.80890327
92MP0002734_abnormal_mechanical_nocicepti0.79550657
93MP0001970_abnormal_pain_threshold0.78349785
94MP0002139_abnormal_hepatobiliary_system0.76785792
95MP0003938_abnormal_ear_development0.76245124
96MP0009643_abnormal_urine_homeostasis0.76055236
97MP0005395_other_phenotype0.75875473
98MP0000003_abnormal_adipose_tissue0.75740252
99MP0000516_abnormal_urinary_system0.74464999
100MP0005367_renal/urinary_system_phenotyp0.74464999
101MP0009379_abnormal_foot_pigmentation0.71950187
102MP0002118_abnormal_lipid_homeostasis0.71726255
103MP0005332_abnormal_amino_acid0.71300869
104MP0003879_abnormal_hair_cell0.70505873
105MP0002160_abnormal_reproductive_system0.68365666
106MP0001756_abnormal_urination0.66937086
107MP0002233_abnormal_nose_morphology0.66663325
108MP0003300_gastrointestinal_ulcer0.65966833
109MP0003953_abnormal_hormone_level0.62744785
110MP0003191_abnormal_cellular_cholesterol0.62423540
111MP0001188_hyperpigmentation0.61540855
112MP0003656_abnormal_erythrocyte_physiolo0.60859603
113MP0005666_abnormal_adipose_tissue0.59420731
114MP0001849_ear_inflammation0.57855892
115MP0000377_abnormal_hair_follicle0.57794790
116MP0008872_abnormal_physiological_respon0.57302780
117MP0005319_abnormal_enzyme/_coenzyme0.57007834
118MP0002693_abnormal_pancreas_physiology0.56931409
119MP0005375_adipose_tissue_phenotype0.56359918
120MP0001764_abnormal_homeostasis0.56124223
121MP0004484_altered_response_of0.54879102
122MP0005166_decreased_susceptibility_to0.54135991
123MP0002877_abnormal_melanocyte_morpholog0.53529624
124MP0000579_abnormal_nail_morphology0.53517122
125MP0005266_abnormal_metabolism0.51491160
126MP0003566_abnormal_cell_adhesion0.51414236
127MP0005377_hearing/vestibular/ear_phenot0.51084612
128MP0003878_abnormal_ear_physiology0.51084612
129MP0000026_abnormal_inner_ear0.49873740
130MP0005310_abnormal_salivary_gland0.49435396
131MP0002896_abnormal_bone_mineralization0.48749824
132MP0002078_abnormal_glucose_homeostasis0.48510625
133MP0009840_abnormal_foam_cell0.48130808
134MP0002837_dystrophic_cardiac_calcinosis0.46565164
135MP0000230_abnormal_systemic_arterial0.45961417
136MP0000609_abnormal_liver_physiology0.45326871
137MP0002822_catalepsy0.45050769
138MP0005334_abnormal_fat_pad0.44898799

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.93616487
2Abnormal ciliary motility (HP:0012262)9.74051377
3Dynein arm defect of respiratory motile cilia (HP:0012255)9.66505618
4Absent/shortened dynein arms (HP:0200106)9.66505618
5Rhinitis (HP:0012384)9.29947899
6Right ventricular cardiomyopathy (HP:0011663)7.95408196
7Chronic bronchitis (HP:0004469)7.72757342
8Bronchiectasis (HP:0002110)6.90750029
9Nasal polyposis (HP:0100582)6.45249693
10Abnormality of the nasal mucosa (HP:0000433)5.56494518
11Abnormal number of erythroid precursors (HP:0012131)4.91909830
12Abnormality of vitamin B metabolism (HP:0004340)4.82689271
13Abnormality of the vitamin B12 metabolism (HP:0004341)4.72701165
14Ileus (HP:0002595)4.64731749
15Woolly hair (HP:0002224)4.42517454
16Abnormality of cells of the erythroid lineage (HP:0012130)4.37360870
17Bronchitis (HP:0012387)4.16811570
18Abnormality of vitamin metabolism (HP:0100508)4.09821615
19Hyperactive renin-angiotensin system (HP:0000841)4.04010248
20Abdominal distention (HP:0003270)4.00856177
21Malnutrition (HP:0004395)4.00439640
22Syncope (HP:0001279)3.95875735
23Recurrent sinusitis (HP:0011108)3.94166874
24Chronic sinusitis (HP:0011109)3.83225081
25Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.76892124
26Infertility (HP:0000789)3.75278396
27Increased IgE level (HP:0003212)3.74888696
28Hyperparathyroidism (HP:0000843)3.73110565
29Conjugated hyperbilirubinemia (HP:0002908)3.71648746
30Ventricular fibrillation (HP:0001663)3.64500663
31Male infertility (HP:0003251)3.58552785
32Recurrent otitis media (HP:0000403)3.52616628
33Palpitations (HP:0001962)3.38963305
34Abnormality of chloride homeostasis (HP:0011422)3.35183152
35Curly hair (HP:0002212)3.22809240
36Megaloblastic anemia (HP:0001889)3.04925040
37Hypoglycemic coma (HP:0001325)3.02713187
38Metabolic alkalosis (HP:0200114)3.01628437
39Chronic otitis media (HP:0000389)3.00648346
40Occipital encephalocele (HP:0002085)2.98688239
41Goiter (HP:0000853)2.93950367
42Late onset (HP:0003584)2.88822125
43Symptomatic seizures (HP:0011145)2.81344938
44Dehydration (HP:0001944)2.77778334
45Congenital ichthyosiform erythroderma (HP:0007431)2.76205506
46Abnormality of small intestinal villus morphology (HP:0011472)2.71952095
47Villous atrophy (HP:0011473)2.71952095
48Atelectasis (HP:0100750)2.65937909
49Onycholysis (HP:0001806)2.57826942
50Ketoacidosis (HP:0001993)2.54784848
51Abnormality of renin-angiotensin system (HP:0000847)2.49823778
52True hermaphroditism (HP:0010459)2.49136392
53Abnormality of glutamine family amino acid metabolism (HP:0010902)2.47070812
54Bundle branch block (HP:0011710)2.44907193
55Pili torti (HP:0003777)2.41825700
56Mildly elevated creatine phosphokinase (HP:0008180)2.39524336
57Flat acetabular roof (HP:0003180)2.39456885
58Hyperkalemia (HP:0002153)2.36962738
59Popliteal pterygium (HP:0009756)2.35291854
60Ventricular tachycardia (HP:0004756)2.35191967
61Cupped ribs (HP:0000887)2.34736870
62Abnormality of the gastric mucosa (HP:0004295)2.34381402
63Pancreatic fibrosis (HP:0100732)2.33168219
64Hyperglycemia (HP:0003074)2.32162403
65Congenital sensorineural hearing impairment (HP:0008527)2.30233819
66Renal salt wasting (HP:0000127)2.29733041
67Cystic liver disease (HP:0006706)2.28534141
68Abnormality of calcium-phosphate metabolism (HP:0100530)2.25954640
69Symphalangism affecting the phalanges of the hand (HP:0009773)2.25533803
70Prolonged QT interval (HP:0001657)2.24182542
71Abnormality of monocarboxylic acid metabolism (HP:0010996)2.23698742
72Lip pit (HP:0100267)2.22551386
73Tubulointerstitial nephritis (HP:0001970)2.20404119
74Abnormal biliary tract morphology (HP:0012440)2.19503134
75Protuberant abdomen (HP:0001538)2.19298958
76Gout (HP:0001997)2.17469033
77Fragile nails (HP:0001808)2.17349503
78Bell-shaped thorax (HP:0001591)2.16546487
79Gastrointestinal dysmotility (HP:0002579)2.15863894
80Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.15576328
81Hyperinsulinemic hypoglycemia (HP:0000825)2.13762940
82Fat malabsorption (HP:0002630)2.10243468
83Intrahepatic cholestasis (HP:0001406)2.10036632
84Hypoplasia of dental enamel (HP:0006297)2.07668831
85Hypoglycemic seizures (HP:0002173)2.05521846
86Chronic diarrhea (HP:0002028)2.03696195
87Hyponatremia (HP:0002902)2.03387703
88Ventricular arrhythmia (HP:0004308)2.01226032
89Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.3441589
90Abnormal respiratory epithelium morphology (HP:0012253)10.1385018
91Abnormal respiratory motile cilium morphology (HP:0005938)10.1385018
92Dysautonomia (HP:0002459)1.99900146
93Abnormality of proline metabolism (HP:0010907)1.99773739
94Hydroxyprolinuria (HP:0003080)1.99773739
95Growth hormone excess (HP:0000845)1.98113054
96Plantar hyperkeratosis (HP:0007556)1.97213326
97Abnormality of purine metabolism (HP:0004352)1.95262573
98Flattened epiphyses (HP:0003071)1.94741955
99Hyperphosphatemia (HP:0002905)1.93696251
100Decreased circulating renin level (HP:0003351)1.92356515
101Alkalosis (HP:0001948)1.90976296
102Molar tooth sign on MRI (HP:0002419)1.90760433
103Abnormality of midbrain morphology (HP:0002418)1.90760433
104Insulin-resistant diabetes mellitus (HP:0000831)1.89718618
105Hyperaldosteronism (HP:0000859)1.89161423
106Nephronophthisis (HP:0000090)1.84740439
107Vascular calcification (HP:0004934)1.83611980
108Pancreatic cysts (HP:0001737)1.83542443
109Chronic hepatic failure (HP:0100626)1.82119281
110Hypoplasia of the uterus (HP:0000013)1.81863110
111Hypotrichosis (HP:0001006)1.81863106
112Exocrine pancreatic insufficiency (HP:0001738)1.80837592
113Abnormal tarsal ossification (HP:0008369)1.80702831
114Milia (HP:0001056)1.80264841
115Abnormality of the 1st metacarpal (HP:0010009)1.78532404
116Postaxial foot polydactyly (HP:0001830)1.78268867
117Absent frontal sinuses (HP:0002688)1.77925094
118Hypokalemia (HP:0002900)1.77288125
119Insulin resistance (HP:0000855)1.77185328
120Micronodular cirrhosis (HP:0001413)1.75705204
121Thin bony cortex (HP:0002753)1.75355054
122Glycosuria (HP:0003076)1.74994263
123Abnormality of urine glucose concentration (HP:0011016)1.74994263
124Adrenal overactivity (HP:0002717)1.74398721
125Corneal erosion (HP:0200020)1.74079739
126Hoarse voice (HP:0001609)1.73738648
127Recurrent bronchitis (HP:0002837)1.72098852
128Rectal prolapse (HP:0002035)1.70794923
129Bradycardia (HP:0001662)1.70484458
130Hypotension (HP:0002615)1.70474752
131Glomerulosclerosis (HP:0000096)1.70460983
132Atrophic scars (HP:0001075)1.70081448
133Widely patent fontanelles and sutures (HP:0004492)1.69340138
134Pancreatitis (HP:0001733)1.67541239
135Ketosis (HP:0001946)1.64618733
136Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.63914866
137Vertebral hypoplasia (HP:0008417)1.63914866
138Neonatal short-limb short stature (HP:0008921)1.63556861
139Short nail (HP:0001799)1.63368347
140Abnormality of the distal phalanges of the toes (HP:0010182)1.63304456
141Tubular atrophy (HP:0000092)1.63282652
142Abnormality of the dental root (HP:0006486)1.56252140
143Taurodontia (HP:0000679)1.56252140
144Abnormality of permanent molar morphology (HP:0011071)1.56252140
145Spinal cord compression (HP:0002176)1.56049043
146Abnormality of the renal medulla (HP:0100957)1.51635071
147Abnormality of sodium homeostasis (HP:0010931)1.50071783
148Abnormality of molar morphology (HP:0011070)1.44422201
149Abnormality of molar (HP:0011077)1.44422201
150Nephropathy (HP:0000112)1.43699012
151Male pseudohermaphroditism (HP:0000037)1.42282807
152Congenital hepatic fibrosis (HP:0002612)1.41978406
153Abnormality of the dental pulp (HP:0006479)1.41886342
154Cone-rod dystrophy (HP:0000548)1.38824933
155Aplasia/Hypoplasia of the tongue (HP:0010295)1.36685129
156Anencephaly (HP:0002323)1.36516273
157Short thorax (HP:0010306)1.36272713
158Stridor (HP:0010307)1.33234143
159Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.32356367
160Hand muscle atrophy (HP:0009130)1.32061685
161Hemorrhage of the eye (HP:0011885)1.31621982
162Furrowed tongue (HP:0000221)1.30645573
163Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.30498564
164Bifid scrotum (HP:0000048)1.27493791
165Abnormal glucose tolerance (HP:0001952)1.27082795
166Abnormality of potassium homeostasis (HP:0011042)1.25702099
167Upper limb amyotrophy (HP:0009129)1.23032750
168Distal upper limb amyotrophy (HP:0007149)1.23032750
169Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.22739523
170Asplenia (HP:0001746)1.21837255
171Aplasia/Hypoplasia of the spleen (HP:0010451)1.21787904
172Aplasia of the musculature (HP:0100854)1.20944128
173Abnormal vertebral ossification (HP:0100569)1.18786051

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.76834539
2MST1R4.29875755
3ERBB44.15720899
4FRK4.10738681
5LMTK23.47686133
6MAP3K22.87474320
7ACVR1B2.85238862
8NME12.80748178
9TESK12.38009643
10MYLK2.23729755
11MAP2K22.22065425
12FER2.18364677
13RIPK42.09848003
14PIK3CG2.07201709
15KSR21.98642582
16PRKG21.96182468
17PTK61.95400204
18SMG11.94463416
19EEF2K1.84431456
20MET1.74335035
21LIMK11.62207877
22NTRK11.58150738
23MAPK151.58054963
24ARAF1.53084220
25MATK1.52651353
26MAP2K11.47853935
27MAPKAPK31.42582284
28WNK41.39605844
29NEK61.33638349
30ERN11.31384243
31TRIB31.30256240
32STK101.26113985
33PRKCI1.24785371
34TTK1.17336792
35PIM21.12394584
36PIK3CA1.11602607
37PTK21.09059569
38LRRK21.08245684
39WNK31.07222033
40BCR1.03454415
41MAP3K101.02497250
42MAP2K61.01127987
43PRKD30.99671128
44LATS10.94540229
45RIPK10.94034009
46PAK30.93826977
47EPHB10.89765305
48MAP3K10.89639478
49TBK10.87240309
50NUAK10.86616994
51EPHB20.83102109
52EPHA20.81768881
53MUSK0.79928506
54STK240.78615772
55MARK20.76160465
56RPS6KA20.70588003
57ROCK10.69847211
58FGFR30.69459462
59MAP3K120.69389518
60INSRR0.68928005
61RPS6KB20.67666743
62CASK0.67099576
63CAMK2D0.65263578
64MAP3K70.64971767
65MAP3K30.64960839
66PRKCE0.64045486
67TAOK10.62334808
68ERBB20.61809084
69PTK2B0.61163930
70ICK0.61137530
71EPHA30.60350918
72STK390.59591047
73TAOK30.59281111
74BRAF0.58730717
75MAP3K90.56779312
76GRK60.56735360
77ADRBK20.56466741
78STK38L0.55701552
79PDPK10.54499475
80ROCK20.53887435
81YES10.50855275
82STK380.48467282
83PRKCD0.47742448
84DMPK0.47389244
85CAMK2G0.46141313
86SIK10.46065470
87ADRBK10.44659194
88STK160.43337654
89CDC42BPA0.42129579
90IRAK10.41810297
91SRC0.41251524
92ERBB30.40691316
93TRPM70.40281338
94MAP3K80.39639728
95MAP3K110.39373356
96DDR20.38925087
97MINK10.38625826
98CAMK2B0.37901991
99PDGFRB0.36829615
100FYN0.36225563
101TLK10.35148761
102GRK50.34863334
103AKT30.34071109
104MAPKAPK20.33712087
105EPHA40.32865520
106ILK0.31463708
107PDK10.31169357
108RET0.31056742
109PRKCZ0.30898824
110PRKCA0.30125672
111PRKAA20.29009936
112CSNK1A10.28431942
113HIPK20.28423142
114SCYL20.26982598
115PAK40.26494225
116PBK0.26246789
117TYK20.25885238
118NLK0.25602550
119AKT20.25032359
120MAP3K130.24873843
121FGFR40.23713097
122PRKCQ0.22903756
123CSK0.22837244
124RPS6KB10.22156872
125BMPR20.21745439
126CAMK2A0.21711263
127PKN20.21418184
128ABL20.20763596
129BRSK20.20390435
130RPS6KA10.19961923
131MAPK110.19642549
132GRK10.18887822
133DYRK1B0.18402895
134OXSR10.18356733
135SGK10.17978044
136PAK10.17651007
137CAMKK10.17029166
138MAPKAPK50.15237802

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009204.47798118
2Fat digestion and absorption_Homo sapiens_hsa049754.07287965
3Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.51543224
4Mineral absorption_Homo sapiens_hsa049783.34339260
5Collecting duct acid secretion_Homo sapiens_hsa049663.06664674
6Gastric acid secretion_Homo sapiens_hsa049712.65595758
7Tyrosine metabolism_Homo sapiens_hsa003502.57307618
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.50264918
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.49127359
10Vitamin digestion and absorption_Homo sapiens_hsa049772.48819886
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.38941511
12Linoleic acid metabolism_Homo sapiens_hsa005912.32924226
13Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.27854574
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.08175112
15Pancreatic secretion_Homo sapiens_hsa049722.00172772
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.97800406
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.82521086
18Glutathione metabolism_Homo sapiens_hsa004801.72484977
19Bile secretion_Homo sapiens_hsa049761.65649719
20Chemical carcinogenesis_Homo sapiens_hsa052041.60761104
21Drug metabolism - other enzymes_Homo sapiens_hsa009831.58969457
22Ether lipid metabolism_Homo sapiens_hsa005651.58710451
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.53773661
24Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.47474927
25Renin-angiotensin system_Homo sapiens_hsa046141.37667030
26Sphingolipid metabolism_Homo sapiens_hsa006001.36340873
27Vibrio cholerae infection_Homo sapiens_hsa051101.30351783
28Histidine metabolism_Homo sapiens_hsa003401.27723901
29Arachidonic acid metabolism_Homo sapiens_hsa005901.27191767
30Fatty acid degradation_Homo sapiens_hsa000711.23163808
31Glycerolipid metabolism_Homo sapiens_hsa005611.20601251
32Galactose metabolism_Homo sapiens_hsa000521.12242310
33Retinol metabolism_Homo sapiens_hsa008301.11937596
34Folate biosynthesis_Homo sapiens_hsa007901.09300911
35Glycerophospholipid metabolism_Homo sapiens_hsa005641.09154923
36Insulin secretion_Homo sapiens_hsa049111.08621174
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08425359
38Arginine and proline metabolism_Homo sapiens_hsa003301.08084472
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05820195
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05798112
41Thyroid hormone synthesis_Homo sapiens_hsa049181.05514381
42Protein digestion and absorption_Homo sapiens_hsa049741.02618085
43Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99439143
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99064778
45Oxidative phosphorylation_Homo sapiens_hsa001900.98995296
46Huntingtons disease_Homo sapiens_hsa050160.96164258
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93831459
48Fructose and mannose metabolism_Homo sapiens_hsa000510.93059879
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87638706
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86804977
51Tight junction_Homo sapiens_hsa045300.86738131
52Thyroid cancer_Homo sapiens_hsa052160.86536207
53PPAR signaling pathway_Homo sapiens_hsa033200.84896423
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84425427
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.84111833
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.83191770
57Starch and sucrose metabolism_Homo sapiens_hsa005000.82816995
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81481657
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78715999
60Caffeine metabolism_Homo sapiens_hsa002320.77477689
61Fatty acid elongation_Homo sapiens_hsa000620.76147478
62Tryptophan metabolism_Homo sapiens_hsa003800.71833583
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69473012
64Renin secretion_Homo sapiens_hsa049240.69363049
65Fatty acid metabolism_Homo sapiens_hsa012120.67796504
66Salivary secretion_Homo sapiens_hsa049700.59740843
67Butanoate metabolism_Homo sapiens_hsa006500.55070081
68ABC transporters_Homo sapiens_hsa020100.54962045
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.48647211
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47667362
71Pyruvate metabolism_Homo sapiens_hsa006200.45901342
72Adherens junction_Homo sapiens_hsa045200.44317633
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42581572
74Taste transduction_Homo sapiens_hsa047420.42429365
75Insulin resistance_Homo sapiens_hsa049310.41987884
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40131490
77Choline metabolism in cancer_Homo sapiens_hsa052310.36597855
78Notch signaling pathway_Homo sapiens_hsa043300.36569021
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34960901
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34695563
81Propanoate metabolism_Homo sapiens_hsa006400.31911802
82Alzheimers disease_Homo sapiens_hsa050100.31733054
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31428446
84Cardiac muscle contraction_Homo sapiens_hsa042600.30650367
85Pentose phosphate pathway_Homo sapiens_hsa000300.30124351
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30082424
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29567129
88Phenylalanine metabolism_Homo sapiens_hsa003600.28685873
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28236581
90Metabolic pathways_Homo sapiens_hsa011000.26152949
91Arginine biosynthesis_Homo sapiens_hsa002200.26044097
92Type II diabetes mellitus_Homo sapiens_hsa049300.25787896
93Nitrogen metabolism_Homo sapiens_hsa009100.25413662
94Cocaine addiction_Homo sapiens_hsa050300.25181211
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.25072866
96GnRH signaling pathway_Homo sapiens_hsa049120.24884735
97Carbon metabolism_Homo sapiens_hsa012000.24732654
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.24442501
99Amoebiasis_Homo sapiens_hsa051460.24367485
100Steroid biosynthesis_Homo sapiens_hsa001000.23562473
101Dorso-ventral axis formation_Homo sapiens_hsa043200.23230934
102Bladder cancer_Homo sapiens_hsa052190.22677324
103beta-Alanine metabolism_Homo sapiens_hsa004100.22440677
104Circadian rhythm_Homo sapiens_hsa047100.21526479
105Long-term depression_Homo sapiens_hsa047300.21338299
106Serotonergic synapse_Homo sapiens_hsa047260.21093301
107Fatty acid biosynthesis_Homo sapiens_hsa000610.19337774
108Hepatitis C_Homo sapiens_hsa051600.19269850
109Salmonella infection_Homo sapiens_hsa051320.19052475
110Other glycan degradation_Homo sapiens_hsa005110.18250942
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.17589940
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.17368229
113Melanogenesis_Homo sapiens_hsa049160.15157411
114VEGF signaling pathway_Homo sapiens_hsa043700.14986882
115Estrogen signaling pathway_Homo sapiens_hsa049150.14767661
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14689371
117Peroxisome_Homo sapiens_hsa041460.14646514
118Synaptic vesicle cycle_Homo sapiens_hsa047210.13250413
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.10044020
120Sulfur relay system_Homo sapiens_hsa041220.09176234
121N-Glycan biosynthesis_Homo sapiens_hsa005100.08219041
122Amphetamine addiction_Homo sapiens_hsa050310.06104644
123Endocytosis_Homo sapiens_hsa041440.06037597
124Ovarian steroidogenesis_Homo sapiens_hsa049130.03893738
125Asthma_Homo sapiens_hsa053100.03698001
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.03586140
127Lysosome_Homo sapiens_hsa041420.03567013

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