CAPN8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1surfactant homeostasis (GO:0043129)7.19243221
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.99808481
3L-phenylalanine catabolic process (GO:0006559)6.99808481
4L-phenylalanine metabolic process (GO:0006558)6.71537197
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.71537197
6aromatic amino acid family catabolic process (GO:0009074)6.69475017
7indole-containing compound catabolic process (GO:0042436)6.50918415
8indolalkylamine catabolic process (GO:0046218)6.50918415
9tryptophan catabolic process (GO:0006569)6.50918415
10kynurenine metabolic process (GO:0070189)6.42598666
11bile acid biosynthetic process (GO:0006699)6.12115619
12complement activation, alternative pathway (GO:0006957)6.09786411
13tryptophan metabolic process (GO:0006568)6.05334912
14regulation of protein activation cascade (GO:2000257)6.03915413
15glyoxylate metabolic process (GO:0046487)5.80106324
16regulation of complement activation (GO:0030449)5.77615920
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.62144873
18urea metabolic process (GO:0019627)5.54790038
19urea cycle (GO:0000050)5.54790038
20cilium or flagellum-dependent cell motility (GO:0001539)5.47466952
21chemical homeostasis within a tissue (GO:0048875)5.43852493
22sulfur amino acid catabolic process (GO:0000098)5.40783240
23axonemal dynein complex assembly (GO:0070286)5.35561044
24peptidyl-glutamic acid carboxylation (GO:0017187)5.30608124
25protein carboxylation (GO:0018214)5.30608124
26negative regulation of fibrinolysis (GO:0051918)5.26634250
27O-glycan processing (GO:0016266)5.25339760
28regulation of fibrinolysis (GO:0051917)5.23444853
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.18225522
30cysteine metabolic process (GO:0006534)5.16667288
31bile acid metabolic process (GO:0008206)5.10522452
32alpha-linolenic acid metabolic process (GO:0036109)5.09163746
33nitrogen cycle metabolic process (GO:0071941)5.07858608
34cytolysis (GO:0019835)4.90950178
35aromatic amino acid family metabolic process (GO:0009072)4.87093320
36high-density lipoprotein particle remodeling (GO:0034375)4.86223016
37regulation of triglyceride catabolic process (GO:0010896)4.79334286
38coenzyme catabolic process (GO:0009109)4.64720384
39serine family amino acid catabolic process (GO:0009071)4.63192964
40bile acid and bile salt transport (GO:0015721)4.58864897
41lysine metabolic process (GO:0006553)4.58331622
42lysine catabolic process (GO:0006554)4.58331622
43indolalkylamine metabolic process (GO:0006586)4.56259092
44homocysteine metabolic process (GO:0050667)4.54470685
45maintenance of gastrointestinal epithelium (GO:0030277)4.52632255
46protein autoprocessing (GO:0016540)4.52383576
47triglyceride homeostasis (GO:0070328)4.50017134
48acylglycerol homeostasis (GO:0055090)4.50017134
49amine catabolic process (GO:0009310)4.39065920
50cellular biogenic amine catabolic process (GO:0042402)4.39065920
51reverse cholesterol transport (GO:0043691)4.38734622
52cellular glucuronidation (GO:0052695)4.37696629
53ethanol oxidation (GO:0006069)4.34196784
54complement activation, classical pathway (GO:0006958)4.34137462
55tyrosine metabolic process (GO:0006570)4.31399615
56alpha-amino acid catabolic process (GO:1901606)4.29125529
57negative regulation of cholesterol transport (GO:0032375)4.24581712
58negative regulation of sterol transport (GO:0032372)4.24581712
59amino-acid betaine metabolic process (GO:0006577)4.20356600
60phospholipid efflux (GO:0033700)4.18107344
61plasma lipoprotein particle remodeling (GO:0034369)4.17725068
62protein-lipid complex remodeling (GO:0034368)4.17725068
63macromolecular complex remodeling (GO:0034367)4.17725068
64desmosome organization (GO:0002934)4.17325985
65glycine metabolic process (GO:0006544)4.14963264
66cellular ketone body metabolic process (GO:0046950)4.13923334
67calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.10551210
68complement activation (GO:0006956)4.10541709
69intestinal epithelial cell development (GO:0060576)4.09766145
70regulation of cholesterol esterification (GO:0010872)4.03712080
71one-carbon compound transport (GO:0019755)4.01864433
72cellular amino acid catabolic process (GO:0009063)4.01369682
73regulation of cholesterol homeostasis (GO:2000188)4.00984872
74benzene-containing compound metabolic process (GO:0042537)4.00019276
75multicellular organismal water homeostasis (GO:0050891)3.99796134
76fibrinolysis (GO:0042730)3.96580965
77serine family amino acid metabolic process (GO:0009069)3.94757870
78glutamate metabolic process (GO:0006536)3.91221728
79phosphatidylserine acyl-chain remodeling (GO:0036150)3.90661384
80protein activation cascade (GO:0072376)3.90616163
81phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.90348028
82glucuronate metabolic process (GO:0019585)3.89974188
83uronic acid metabolic process (GO:0006063)3.89974188
84vitamin transmembrane transport (GO:0035461)3.88923164
85imidazole-containing compound metabolic process (GO:0052803)3.88385683
86cholesterol efflux (GO:0033344)3.86016202
87cilium movement (GO:0003341)3.85137106
88negative regulation of complement activation (GO:0045916)3.83480257
89negative regulation of humoral immune response (GO:0002921)3.83368568
90cellular modified amino acid catabolic process (GO:0042219)3.83344964
91plasma lipoprotein particle clearance (GO:0034381)3.81803790
92positive regulation of lipoprotein lipase activity (GO:0051006)3.78357649
93positive regulation of triglyceride lipase activity (GO:0061365)3.78357649
94arginine metabolic process (GO:0006525)3.77187971
95dicarboxylic acid biosynthetic process (GO:0043650)3.77177382
96regulation of bile acid biosynthetic process (GO:0070857)3.76638230
97sulfate transmembrane transport (GO:1902358)3.75848238
98bundle of His cell to Purkinje myocyte communication (GO:0086069)3.72792978
99serine family amino acid biosynthetic process (GO:0009070)3.70678810
100acetyl-CoA metabolic process (GO:0006084)3.67250125
101negative regulation of transcription by competitive promoter binding (GO:0010944)3.64703996
102cholesterol homeostasis (GO:0042632)3.64336500
103primary alcohol catabolic process (GO:0034310)3.62820296
104flavonoid metabolic process (GO:0009812)3.62727555
105cofactor catabolic process (GO:0051187)3.61924392
106blood coagulation, intrinsic pathway (GO:0007597)3.61180479
107aldehyde catabolic process (GO:0046185)3.60083278
108ketone body metabolic process (GO:1902224)3.59369399
109sterol homeostasis (GO:0055092)3.59308852
110plasma lipoprotein particle assembly (GO:0034377)3.58338344
111negative regulation of protein activation cascade (GO:2000258)3.55126346
112striated muscle atrophy (GO:0014891)3.54407844
113regulation of ruffle assembly (GO:1900027)3.53956797
114phospholipid homeostasis (GO:0055091)3.53330748
115lung epithelium development (GO:0060428)3.53196274
116trivalent inorganic anion homeostasis (GO:0072506)3.52708007
117phosphate ion homeostasis (GO:0055062)3.52708007
118sodium ion homeostasis (GO:0055078)3.50125843
119intestinal cholesterol absorption (GO:0030299)3.50122412
120acute-phase response (GO:0006953)3.49491684
121carboxylic acid catabolic process (GO:0046395)3.49170271
122organic acid catabolic process (GO:0016054)3.49170271
123heme transport (GO:0015886)3.47644454
124protein O-linked glycosylation (GO:0006493)3.47144416
125renal filtration (GO:0097205)3.46330646
126very-low-density lipoprotein particle assembly (GO:0034379)3.43898981
127drug transmembrane transport (GO:0006855)3.41441841
128ethanol metabolic process (GO:0006067)3.41015556
129epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.40128627
130lung secretory cell differentiation (GO:0061140)3.39957577
131regulation of humoral immune response (GO:0002920)3.39847102
132positive regulation of lipid catabolic process (GO:0050996)3.39731900
133glomerular filtration (GO:0003094)3.38146730
134urate metabolic process (GO:0046415)3.37981684
135water homeostasis (GO:0030104)3.33054363
136epithelial structure maintenance (GO:0010669)3.29943433
137epithelial cell-cell adhesion (GO:0090136)3.23487291
138motile cilium assembly (GO:0044458)3.21127204
139phosphatidylinositol acyl-chain remodeling (GO:0036149)3.20441673
140negative regulation of myotube differentiation (GO:0010832)3.19350291
141skeletal muscle adaptation (GO:0043501)3.15801757
142positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.15708472
143tooth mineralization (GO:0034505)3.13936116
144amyloid precursor protein metabolic process (GO:0042982)3.12352110
145pyrimidine-containing compound transmembrane transport (GO:0072531)3.06238424
146semaphorin-plexin signaling pathway (GO:0071526)3.03725899
147intestinal absorption (GO:0050892)3.03650800
148regulation of viral release from host cell (GO:1902186)2.97253538
149renal absorption (GO:0070293)2.96732191
150sulfate transport (GO:0008272)2.96474213
151muscle atrophy (GO:0014889)2.93530779
152phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.93229421
153auditory receptor cell differentiation (GO:0042491)2.86884001
154negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.86775829
155regulation of T-helper 2 cell differentiation (GO:0045628)2.86279024
156phosphate ion transmembrane transport (GO:0035435)2.85451670
157phosphatidylserine metabolic process (GO:0006658)2.85228399
158water transport (GO:0006833)2.85011560
159excretion (GO:0007588)2.83448863
160tight junction assembly (GO:0070830)2.80098447
161diterpenoid biosynthetic process (GO:0016102)2.79653094
162oligosaccharide biosynthetic process (GO:0009312)2.77734645
163negative regulation of protein tyrosine kinase activity (GO:0061099)2.74831566
164negative regulation of T-helper cell differentiation (GO:0045623)2.73359448
165negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.73359448
166icosanoid transport (GO:0071715)2.72587685
167fatty acid derivative transport (GO:1901571)2.72587685
168drug transport (GO:0015893)2.70276822
169arachidonic acid secretion (GO:0050482)2.70168031
170icosanoid secretion (GO:0032309)2.70168031
171columnar/cuboidal epithelial cell development (GO:0002066)2.68749806
172alditol phosphate metabolic process (GO:0052646)2.68446385
173epithelial cilium movement (GO:0003351)2.67750756
174regulation of respiratory burst (GO:0060263)2.66216409
175cytoskeletal anchoring at plasma membrane (GO:0007016)2.61851338
176endothelial cell chemotaxis (GO:0035767)2.59650627
177dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.59476246
178fluid transport (GO:0042044)2.59439653
179renal system process involved in regulation of blood volume (GO:0001977)2.55691108
180drug catabolic process (GO:0042737)2.55319789
181negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.55121993
182detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.54034339
183positive regulation of Cdc42 GTPase activity (GO:0043089)2.53620297
184phosphatidylcholine acyl-chain remodeling (GO:0036151)2.53499381
185positive regulation of respiratory burst (GO:0060267)2.53071509
186lung vasculature development (GO:0060426)2.48957039
187axoneme assembly (GO:0035082)2.48449543
188iron ion import (GO:0097286)2.47828491
189receptor catabolic process (GO:0032801)2.46072616
190regulation of water loss via skin (GO:0033561)2.44826712
191glutathione biosynthetic process (GO:0006750)2.43685610

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.59822983
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.70629199
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.68144621
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.98219383
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.72353262
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.41971212
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.34151494
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.01533683
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.36075854
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.72018150
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.39399926
12* RUNX1_27514584_Chip-Seq_MCF-7_Human2.31026237
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.22371702
14DROSHA_22980978_ChIP-Seq_HELA_Human2.16235548
15* ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.9051375
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.99151882
17KLF5_25053715_ChIP-Seq_YYC3_Human1.97083251
18SOX2_27498859_Chip-Seq_STOMACH_Mouse1.85658625
19TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.75417424
20STAT6_21828071_ChIP-Seq_BEAS2B_Human1.74023214
21AHR_22903824_ChIP-Seq_MCF-7_Human1.71170684
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70825064
23FOXA2_19822575_ChIP-Seq_HepG2_Human1.67157020
24GATA2_21666600_ChIP-Seq_HMVEC_Human1.48764020
25ARNT_22903824_ChIP-Seq_MCF-7_Human1.47328000
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44600047
27CLOCK_20551151_ChIP-Seq_293T_Human1.44152547
28GATA4_25053715_ChIP-Seq_YYC3_Human1.43724385
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.42756722
30ESR1_15608294_ChIP-ChIP_MCF-7_Human1.41007972
31HNF4A_19822575_ChIP-Seq_HepG2_Human1.37286473
32HTT_18923047_ChIP-ChIP_STHdh_Human1.33672255
33CTNNB1_20460455_ChIP-Seq_HCT116_Human1.29234102
34TCF4_18268006_ChIP-ChIP_LS174T_Human1.24028198
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.23310813
36* ESR2_21235772_ChIP-Seq_MCF-7_Human1.22988617
37AR_21572438_ChIP-Seq_LNCaP_Human1.22388324
38GATA1_22025678_ChIP-Seq_K562_Human1.21103925
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20752783
40RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19851595
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19627121
42CREB1_26743006_Chip-Seq_LNCaP_Human1.19256698
43FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18224028
44SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.15799105
45SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.15799105
46* TP63_22573176_ChIP-Seq_HFKS_Human1.14901883
47NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14050868
48CDX2_20551321_ChIP-Seq_CACO-2_Human1.13668719
49RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12408635
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10880078
51CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10795820
52CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10676251
53* ESR1_21235772_ChIP-Seq_MCF-7_Human1.10319682
54ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08299792
55KAP1_22055183_ChIP-Seq_ESCs_Mouse1.02737957
56CTCF_27219007_Chip-Seq_Bcells_Human1.00464731
57AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00095885
58GATA1_19941826_ChIP-Seq_K562_Human0.99896554
59FOXO3_23340844_ChIP-Seq_DLD1_Human0.98758497
60* CJUN_26792858_Chip-Seq_BT549_Human0.98040858
61GATA6_25053715_ChIP-Seq_YYC3_Human0.96995873
62ELK3_25401928_ChIP-Seq_HUVEC_Human0.94152537
63CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93449211
64KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93405518
65KDM2B_26808549_Chip-Seq_K562_Human0.90551794
66SOX2_20726797_ChIP-Seq_SW620_Human0.90081790
67BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.88934985
68PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88366715
69EGR1_19032775_ChIP-ChIP_M12_Human0.87396637
70CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.86837724
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86649505
72ESR1_20079471_ChIP-ChIP_T-47D_Human0.86302718
73* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83636283
74SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.83295639
75SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.82824252
76STAT1_20625510_ChIP-Seq_HELA_Human0.82108071
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82003108
78VDR_22108803_ChIP-Seq_LS180_Human0.81828723
79GATA1_19941827_ChIP-Seq_MEL_Mouse0.81346744
80SMC4_20622854_ChIP-Seq_HELA_Human0.81100115
81RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.80629052
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.80524761
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79754321
84FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.77518516
85GATA2_19941826_ChIP-Seq_K562_Human0.77470925
86SMAD3_21741376_ChIP-Seq_HESCs_Human0.76870879
87NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76850989
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76850989
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76752653
90ATF3_27146783_Chip-Seq_COLON_Human0.76266880
91FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.75621665
92Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.75460287
93RARA_24833708_ChIP-Seq_LIVER_Mouse0.75017638
94EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.74514507
95PPAR_26484153_Chip-Seq_NCI-H1993_Human0.74375021
96SALL4_18804426_ChIP-ChIP_XEN_Mouse0.74303599
97FOXA1_25552417_ChIP-Seq_VCAP_Human0.73985675
98ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.73298170
99GATA3_24758297_ChIP-Seq_MCF-7_Human0.72178572
100ZNF263_19887448_ChIP-Seq_K562_Human0.71687634
101SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.70858977
102LXR_22292898_ChIP-Seq_THP-1_Human0.70311411
103TBX20_22080862_ChIP-Seq_HEART_Mouse0.70121403
104TBX20_22328084_ChIP-Seq_HEART_Mouse0.70121403
105RXR_22108803_ChIP-Seq_LS180_Human0.69795076
106* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.69479506
107* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.69282356
108AUTS2_25519132_ChIP-Seq_293T-REX_Human0.69015820
109ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.68704962
110TRIM28_21343339_ChIP-Seq_HEK293_Human0.67121602
111* CEBPB_22108803_ChIP-Seq_LS180_Human0.66057767
112P53_21459846_ChIP-Seq_SAOS-2_Human0.65632664
113RARB_24833708_ChIP-Seq_LIVER_Mouse0.64945281
114BCAT_22108803_ChIP-Seq_LS180_Human0.63456182
115PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.61944343
116AR_20517297_ChIP-Seq_VCAP_Human0.61937912
117ERG_20517297_ChIP-Seq_VCAP_Human0.61133873
118SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.60684887
119ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.60232473
120NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.59935411
121STAT3_1855785_ChIP-Seq_MESCs_Mouse0.59671808
122RACK7_27058665_Chip-Seq_MCF-7_Human0.59111994
123GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.58088656
124ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.57561808
125* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.57552487
126TAF2_19829295_ChIP-Seq_ESCs_Human0.57434946
127FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.57031143
128MYC_19915707_ChIP-ChIP_AK7_Human0.56752918
129P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.56142143
130* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.55957965
131ZNF217_24962896_ChIP-Seq_MCF-7_Human0.55067985
132IRF8_22096565_ChIP-ChIP_GC-B_Human0.54609538
133SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.53699176
134SOX9_24532713_ChIP-Seq_HFSC_Mouse0.53585752
135SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.52402748
136PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.51379916
137NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.48681724
138CDX2_22108803_ChIP-Seq_LS180_Human0.48270055
139TP63_23658742_ChIP-Seq_EP156T_Human0.48268293
140KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.47551532
141KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.47485504
142ESET_19884257_ChIP-Seq_ESCs_Mouse0.46988758
143BCOR_27268052_Chip-Seq_Bcells_Human0.46241078
144PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.45738152
145STAT1_17558387_ChIP-Seq_HELA_Human0.45688026

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.69648334
2MP0005360_urolithiasis7.31091481
3MP0005085_abnormal_gallbladder_physiolo6.20642542
4MP0005365_abnormal_bile_salt5.67811674
5MP0003806_abnormal_nucleotide_metabolis4.78489511
6MP0008875_abnormal_xenobiotic_pharmacok4.15567599
7MP0003252_abnormal_bile_duct3.77055765
8MP0010329_abnormal_lipoprotein_level3.34976081
9MP0004043_abnormal_pH_regulation3.28222863
10MP0001666_abnormal_nutrient_absorption3.08846023
11MP0000566_synostosis2.97290073
12MP0009840_abnormal_foam_cell2.71013172
13MP0005083_abnormal_biliary_tract2.70404974
14MP0008004_abnormal_stomach_pH2.56109543
15MP0003195_calcinosis2.37795432
16MP0005332_abnormal_amino_acid2.37271454
17MP0000465_gastrointestinal_hemorrhage2.32829510
18MP0003191_abnormal_cellular_cholesterol2.29803218
19MP0001958_emphysema2.18323809
20MP0009780_abnormal_chondrocyte_physiolo2.17824809
21MP0010155_abnormal_intestine_physiology2.17673995
22MP0003866_abnormal_defecation2.16148377
23MP0010352_gastrointestinal_tract_polyps2.08222739
24MP0000579_abnormal_nail_morphology2.00648053
25MP0000609_abnormal_liver_physiology1.98887298
26MP0003868_abnormal_feces_composition1.93863842
27MP0002118_abnormal_lipid_homeostasis1.91167486
28MP0004019_abnormal_vitamin_homeostasis1.90848505
29MP0003705_abnormal_hypodermis_morpholog1.89819486
30MP0000678_abnormal_parathyroid_gland1.86723064
31MP0001765_abnormal_ion_homeostasis1.83734848
32MP0008961_abnormal_basal_metabolism1.81161720
33MP0005319_abnormal_enzyme/_coenzyme1.68430014
34MP0002138_abnormal_hepatobiliary_system1.66180165
35MP0002254_reproductive_system_inflammat1.62907958
36MP0001849_ear_inflammation1.60246817
37MP0010234_abnormal_vibrissa_follicle1.59624105
38MP0000477_abnormal_intestine_morphology1.53437679
39MP0002796_impaired_skin_barrier1.50806641
40MP0005584_abnormal_enzyme/coenzyme_acti1.33850635
41MP0002098_abnormal_vibrissa_morphology1.33756052
42MP0009697_abnormal_copulation1.32929240
43MP0001764_abnormal_homeostasis1.30823637
44MP0002132_abnormal_respiratory_system1.25867751
45MP0002249_abnormal_larynx_morphology1.22126944
46MP0005647_abnormal_sex_gland1.20302992
47MP0004381_abnormal_hair_follicle1.19134469
48MP0004264_abnormal_extraembryonic_tissu1.16494016
49MP0009643_abnormal_urine_homeostasis1.13746232
50MP0005503_abnormal_tendon_morphology1.12752392
51MP0000427_abnormal_hair_cycle1.10440499
52MP0003011_delayed_dark_adaptation1.08796685
53MP0003186_abnormal_redox_activity1.06440889
54MP0000681_abnormal_thyroid_gland1.06021243
55MP0000647_abnormal_sebaceous_gland1.05880219
56MP0005023_abnormal_wound_healing1.04913429
57* MP0005165_increased_susceptibility_to1.02263617
58MP0005367_renal/urinary_system_phenotyp1.01918360
59MP0000516_abnormal_urinary_system1.01918360
60MP0000598_abnormal_liver_morphology1.01725146
61MP0002168_other_aberrant_phenotype0.99084098
62MP0005636_abnormal_mineral_homeostasis0.98411121
63MP0005164_abnormal_response_to0.98153431
64MP0005076_abnormal_cell_differentiation0.98024984
65MP0003045_fibrosis0.97104378
66MP0005058_abnormal_lysosome_morphology0.96344445
67MP0003656_abnormal_erythrocyte_physiolo0.95902978
68MP0002653_abnormal_ependyma_morphology0.95569989
69MP0000462_abnormal_digestive_system0.93529569
70MP0010678_abnormal_skin_adnexa0.92615987
71MP0009764_decreased_sensitivity_to0.91055862
72MP0002896_abnormal_bone_mineralization0.90872161
73MP0001873_stomach_inflammation0.90849429
74MP0001502_abnormal_circadian_rhythm0.90467768
75MP0000377_abnormal_hair_follicle0.90189990
76MP0009053_abnormal_anal_canal0.89427061
77MP0000013_abnormal_adipose_tissue0.88850457
78MP0005409_darkened_coat_color0.88067629
79MP0005451_abnormal_body_composition0.87213704
80MP0010368_abnormal_lymphatic_system0.87016875
81MP0005388_respiratory_system_phenotype0.85975564
82MP0002133_abnormal_respiratory_system0.85975564
83MP0000490_abnormal_crypts_of0.85501824
84MP0009384_cardiac_valve_regurgitation0.84547927
85MP0003879_abnormal_hair_cell0.84025425
86MP0000604_amyloidosis0.83447127
87MP0008872_abnormal_physiological_respon0.82770498
88MP0005408_hypopigmentation0.81157069
89MP0003724_increased_susceptibility_to0.80639436
90MP0001664_abnormal_digestion0.80351961
91MP0008469_abnormal_protein_level0.79862840
92MP0000383_abnormal_hair_follicle0.79795847
93MP0009763_increased_sensitivity_to0.79606906
94MP0004272_abnormal_basement_membrane0.79126044
95MP0009642_abnormal_blood_homeostasis0.78307882
96MP0005501_abnormal_skin_physiology0.77018629
97MP0002876_abnormal_thyroid_physiology0.75057691
98MP0000627_abnormal_mammary_gland0.74855053
99MP0003091_abnormal_cell_migration0.73305146
100MP0005220_abnormal_exocrine_pancreas0.73177839
101MP0003566_abnormal_cell_adhesion0.73103514
102MP0003453_abnormal_keratinocyte_physiol0.72785581
103MP0002822_catalepsy0.70993423
104MP0002078_abnormal_glucose_homeostasis0.69427623
105MP0002060_abnormal_skin_morphology0.69400337
106MP0005266_abnormal_metabolism0.69198221
107MP0005376_homeostasis/metabolism_phenot0.68681199
108MP0009379_abnormal_foot_pigmentation0.68300313
109MP0004947_skin_inflammation0.67424441
110MP0000249_abnormal_blood_vessel0.67158674
111MP0001661_extended_life_span0.66582667
112MP0004484_altered_response_of0.66103420
113MP0005084_abnormal_gallbladder_morpholo0.66055328
114MP0010386_abnormal_urinary_bladder0.65306140
115MP0001270_distended_abdomen0.64022933
116MP0000467_abnormal_esophagus_morphology0.63980537
117MP0003943_abnormal_hepatobiliary_system0.63965330
118MP0001216_abnormal_epidermal_layer0.63806184
119MP0001485_abnormal_pinna_reflex0.63743177
120MP0005248_abnormal_Harderian_gland0.62634596
121MP0001243_abnormal_dermal_layer0.60313642
122MP0002998_abnormal_bone_remodeling0.60100675
123MP0002282_abnormal_trachea_morphology0.59703250
124MP0005334_abnormal_fat_pad0.59264607
125MP0002933_joint_inflammation0.58813336
126MP0009765_abnormal_xenobiotic_induced0.58745171
127MP0000613_abnormal_salivary_gland0.58538344
128MP0005166_decreased_susceptibility_to0.58228902
129MP0002932_abnormal_joint_morphology0.58053726
130MP0006138_congestive_heart_failure0.57512198
131MP0002971_abnormal_brown_adipose0.56801003
132MP0005535_abnormal_body_temperature0.53130245
133MP0000367_abnormal_coat/_hair0.52622929
134MP0006036_abnormal_mitochondrial_physio0.51729856
135MP0004130_abnormal_muscle_cell0.51583998
136MP0005275_abnormal_skin_tensile0.50786177
137MP0000470_abnormal_stomach_morphology0.46962377
138MP0001663_abnormal_digestive_system0.46190372
139MP0005448_abnormal_energy_balance0.45204576
140MP0001756_abnormal_urination0.42285117
141MP0005666_abnormal_adipose_tissue0.42104187
142MP0004782_abnormal_surfactant_physiolog0.42005243
143MP0005670_abnormal_white_adipose0.41806503
144MP0005381_digestive/alimentary_phenotyp0.41218460
145MP0005075_abnormal_melanosome_morpholog0.40904964
146MP0003690_abnormal_glial_cell0.40061103
147MP0010771_integument_phenotype0.40010008
148MP0009931_abnormal_skin_appearance0.39409296
149MP0002136_abnormal_kidney_physiology0.38605711
150MP0003638_abnormal_response/metabolism_0.37936565
151MP0003953_abnormal_hormone_level0.37916292
152MP0000639_abnormal_adrenal_gland0.36877282
153MP0005395_other_phenotype0.36596093
154MP0004185_abnormal_adipocyte_glucose0.36425755
155MP0001881_abnormal_mammary_gland0.36410816

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)8.01250085
2Intrahepatic cholestasis (HP:0001406)7.98913791
3Deep venous thrombosis (HP:0002625)7.01464009
4Complement deficiency (HP:0004431)6.96339351
5Abnormality of aromatic amino acid family metabolism (HP:0004338)6.64425983
6Chronic bronchitis (HP:0004469)6.48719167
7Prolonged partial thromboplastin time (HP:0003645)6.30292682
8Abnormality of monocarboxylic acid metabolism (HP:0010996)6.28669337
9Xanthomatosis (HP:0000991)5.92442324
10Hypobetalipoproteinemia (HP:0003563)5.88958282
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.72280498
12Decreased circulating renin level (HP:0003351)5.33910988
13Abnormality of complement system (HP:0005339)5.13045029
14Hyperlipoproteinemia (HP:0010980)4.81974264
15Interstitial pulmonary disease (HP:0006530)4.70337484
16Hyperkalemia (HP:0002153)4.68526638
17Fat malabsorption (HP:0002630)4.65981835
18Abnormality of renin-angiotensin system (HP:0000847)4.58982701
19Abnormality of chloride homeostasis (HP:0011422)4.56236813
20Abnormal respiratory motile cilium physiology (HP:0012261)4.54003905
21Abnormality of the common coagulation pathway (HP:0010990)4.47821300
22Renal salt wasting (HP:0000127)4.46647155
23Hypolipoproteinemia (HP:0010981)4.46338057
24Epidermoid cyst (HP:0200040)4.42433486
25Absent/shortened dynein arms (HP:0200106)4.34152703
26Dynein arm defect of respiratory motile cilia (HP:0012255)4.34152703
27Hyperglycinemia (HP:0002154)4.33836720
28Abnormal respiratory motile cilium morphology (HP:0005938)4.31848532
29Abnormal respiratory epithelium morphology (HP:0012253)4.31848532
30Joint hemorrhage (HP:0005261)4.30516231
31Hyperammonemia (HP:0001987)4.26591209
32Rhinitis (HP:0012384)4.19978950
33Abnormal ciliary motility (HP:0012262)4.15356437
34Conjugated hyperbilirubinemia (HP:0002908)4.09193705
35Hyperaldosteronism (HP:0000859)4.04708159
36Ketosis (HP:0001946)4.03731242
37Tubulointerstitial nephritis (HP:0001970)4.01620247
38Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.00154366
39Abnormality of sulfur amino acid metabolism (HP:0004339)3.93251385
40Hypoglycemic coma (HP:0001325)3.91146348
41Abnormality of the intrinsic pathway (HP:0010989)3.89029479
42Bronchiectasis (HP:0002110)3.86704029
43Abnormality of glutamine family amino acid metabolism (HP:0010902)3.86293779
44Hypoalphalipoproteinemia (HP:0003233)3.86157170
45Abnormality of serine family amino acid metabolism (HP:0010894)3.67227315
46Abnormality of glycine metabolism (HP:0010895)3.67227315
47Amelogenesis imperfecta (HP:0000705)3.66725385
48Hyperglycinuria (HP:0003108)3.62878989
49Abnormality of aspartate family amino acid metabolism (HP:0010899)3.53218750
50Steatorrhea (HP:0002570)3.49818723
51Recurrent gram-negative bacterial infections (HP:0005420)3.38049688
52Abnormality of methionine metabolism (HP:0010901)3.34359730
53Bronchitis (HP:0012387)3.34311656
54Systemic lupus erythematosus (HP:0002725)3.32386914
55Flat acetabular roof (HP:0003180)3.27711811
56Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.21731134
57Hypochromic microcytic anemia (HP:0004840)3.20966251
58Tubulointerstitial fibrosis (HP:0005576)3.20353790
59Hyponatremia (HP:0002902)3.19619904
60Abnormality of fatty-acid metabolism (HP:0004359)3.14693195
61Spontaneous abortion (HP:0005268)3.13789716
62Abnormality of pyrimidine metabolism (HP:0004353)3.13311952
63Hypercholesterolemia (HP:0003124)3.05880980
64Ketoacidosis (HP:0001993)3.03566460
65Myocardial infarction (HP:0001658)2.97536380
66Hyperbilirubinemia (HP:0002904)2.96511778
67Abnormality of nucleobase metabolism (HP:0010932)2.94122886
68Tubular atrophy (HP:0000092)2.93199974
69Nasal polyposis (HP:0100582)2.90046133
70Lip pit (HP:0100267)2.89215667
71Abnormality of the nasal mucosa (HP:0000433)2.88358951
72Hepatocellular carcinoma (HP:0001402)2.86773817
73Abnormality of purine metabolism (HP:0004352)2.84528353
74Cervical subluxation (HP:0003308)2.78757016
75Broad face (HP:0000283)2.78138893
76Gout (HP:0001997)2.77228014
77J-shaped sella turcica (HP:0002680)2.76729083
78Glomerulosclerosis (HP:0000096)2.76122802
79Abnormality of the dental pulp (HP:0006479)2.75921411
80Delayed CNS myelination (HP:0002188)2.73321981
81Abnormality of serum amino acid levels (HP:0003112)2.69185421
82Malnutrition (HP:0004395)2.62553559
83Hypoglycemic seizures (HP:0002173)2.59419430
84Metabolic acidosis (HP:0001942)2.59410662
85Skin nodule (HP:0200036)2.58030557
86Pili torti (HP:0003777)2.57590974
87Vascular calcification (HP:0004934)2.56424274
88Abnormality of sodium homeostasis (HP:0010931)2.53499432
89Neonatal onset (HP:0003623)2.50334585
90Spastic diplegia (HP:0001264)2.46527286
91Late onset (HP:0003584)2.46367916
92Sensorimotor neuropathy (HP:0007141)2.43845191
93Mildly elevated creatine phosphokinase (HP:0008180)2.43266854
94Abnormality of potassium homeostasis (HP:0011042)2.40219647
95Alkalosis (HP:0001948)2.38958357
96Metabolic alkalosis (HP:0200114)2.38272738
97Lethargy (HP:0001254)2.37996597
98Dicarboxylic aciduria (HP:0003215)2.37041859
99Abnormality of dicarboxylic acid metabolism (HP:0010995)2.37041859
100Acanthocytosis (HP:0001927)2.36815699
101Abnormal gallbladder morphology (HP:0012437)2.33339353
102Right ventricular cardiomyopathy (HP:0011663)2.33230552
103Cholelithiasis (HP:0001081)2.30801757
104Cardiovascular calcification (HP:0011915)2.28261312
105Obstructive sleep apnea (HP:0002870)2.22765720
106Pancreatitis (HP:0001733)2.21578287
107Focal segmental glomerulosclerosis (HP:0000097)2.21575994
108Tubulointerstitial abnormality (HP:0001969)2.21275505
109Hemorrhage of the eye (HP:0011885)2.20972725
110Hyperinsulinemic hypoglycemia (HP:0000825)2.18122944
111Gingival bleeding (HP:0000225)2.15613886
112Esophageal varix (HP:0002040)2.14939719
113Adrenal overactivity (HP:0002717)2.14707526
114Amyloidosis (HP:0011034)2.13974413
115Hypotension (HP:0002615)2.10613268
116Woolly hair (HP:0002224)2.10491675
117Glomerulonephritis (HP:0000099)2.09888581
118Hyperglycemia (HP:0003074)2.08415832
119Cholecystitis (HP:0001082)2.08176140
120Abnormal gallbladder physiology (HP:0012438)2.08176140
121Stage 5 chronic kidney disease (HP:0003774)2.07438039
122Tachypnea (HP:0002789)2.06876502
123Irritability (HP:0000737)2.06819799
124Abnormality of calcium-phosphate metabolism (HP:0100530)2.06654789
125Abnormality of vitamin metabolism (HP:0100508)2.05363605
126Abnormality of renal excretion (HP:0011036)2.03515240
127Recurrent otitis media (HP:0000403)2.03029634
128Mitral stenosis (HP:0001718)2.02972308
129Atelectasis (HP:0100750)2.00379985
130Male infertility (HP:0003251)1.98714853
131Abnormal cartilage morphology (HP:0002763)1.98695766
132Rickets (HP:0002748)1.98027832
133Thin bony cortex (HP:0002753)1.97962237
134Alopecia of scalp (HP:0002293)1.96466576
135Abnormality of the gallbladder (HP:0005264)1.96376237
136Cerebral palsy (HP:0100021)1.93778101
137Enlarged kidneys (HP:0000105)1.93428155
138Abnormal enzyme/coenzyme activity (HP:0012379)1.92844451
139Abdominal distention (HP:0003270)1.92753429
140Cerebral edema (HP:0002181)1.92729725
141Opisthotonus (HP:0002179)1.91285881
142Abnormal hair laboratory examination (HP:0003328)1.90275871
143Thrombophlebitis (HP:0004418)1.89507165
144Abnormality of the fingertips (HP:0001211)1.89167644
145Vomiting (HP:0002013)1.88961292
146Menorrhagia (HP:0000132)1.87889151
147Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.87823212
148Dehydration (HP:0001944)1.87065787
149Brushfield spots (HP:0001088)1.86654143
150Cone-rod dystrophy (HP:0000548)1.86045131
151Symptomatic seizures (HP:0011145)1.85401719
152Nuclear cataract (HP:0100018)1.84535037
153Neonatal short-limb short stature (HP:0008921)1.84212605
154Hypokalemia (HP:0002900)1.83880517
155Growth hormone excess (HP:0000845)1.83665973
156Generalized aminoaciduria (HP:0002909)1.82025961
157Alveolar cell carcinoma (HP:0006519)1.81661495
158Brittle hair (HP:0002299)1.81528951
159Hypophosphatemic rickets (HP:0004912)1.81218141
160Chronic sinusitis (HP:0011109)1.81172324
161Hypotrichosis (HP:0001006)1.81003539
162Nephritis (HP:0000123)1.80342047
163Hydroxyprolinuria (HP:0003080)1.77580794
164Abnormality of proline metabolism (HP:0010907)1.77580794
165Stridor (HP:0010307)1.76358545
166Aortic regurgitation (HP:0001659)1.75989380
167Abnormality of transition element cation homeostasis (HP:0011030)1.75422928
168Elevated hepatic transaminases (HP:0002910)1.74365819
169Abnormality of the renal medulla (HP:0100957)1.73614953
170Mucopolysacchariduria (HP:0008155)1.73006417
171Urinary glycosaminoglycan excretion (HP:0003541)1.73006417
172Spinal cord compression (HP:0002176)1.72994397
173Short nail (HP:0001799)1.72542140
174Abnormality of small intestinal villus morphology (HP:0011472)1.69016262
175Villous atrophy (HP:0011473)1.69016262
176Congenital sensorineural hearing impairment (HP:0008527)1.68049607
177Bronchomalacia (HP:0002780)1.67820603
178Overgrowth (HP:0001548)1.67529624
179Visceral angiomatosis (HP:0100761)1.67432315
180Infertility (HP:0000789)1.67249473
181Syncope (HP:0001279)1.66978598
182Abnormality of dental color (HP:0011073)1.66244868
183Abnormality of the dental root (HP:0006486)1.65455289
184Taurodontia (HP:0000679)1.65455289
185Abnormality of permanent molar morphology (HP:0011071)1.65455289
186Abnormal vertebral ossification (HP:0100569)1.64260530
187Recurrent sinusitis (HP:0011108)1.63582613
188Abnormality of the gastric mucosa (HP:0004295)1.63157789
189Cerebral aneurysm (HP:0004944)1.62257931
190Pigmentary retinal degeneration (HP:0001146)1.61998338

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB45.95782768
2BCKDK5.26124998
3ERN15.13568610
4FGFR44.14585376
5MST1R3.40620025
6SIK13.16107101
7PIK3CG2.96559509
8TAOK32.95360040
9FRK2.78536664
10INSRR2.40211642
11LATS12.13669885
12TRIB32.02927429
13NME11.98525391
14PTK61.91309431
15STK391.89324800
16MAPK111.79951726
17MAP2K41.79590012
18MET1.39976680
19NEK91.38078650
20WNK41.35549356
21MAP3K31.35169644
22EPHA21.34992421
23TYK21.30888668
24ERBB21.27061628
25ZAP701.25703118
26CDC42BPA1.22522642
27PKN21.20194695
28EPHB11.18014168
29BLK1.15750033
30MAP3K71.15242275
31EPHA31.14555544
32FGFR21.11782520
33PAK41.09388362
34RIPK11.07431845
35JAK21.06159989
36MAP3K101.05661601
37GRK61.02954125
38PDGFRB1.02294127
39STK38L1.01689128
40FER1.01207197
41ABL20.95714902
42MAP2K30.95612922
43MAP2K60.94399938
44PRKAA20.92527729
45FLT30.92268057
46PRKCI0.91512122
47CDK60.89339496
48NTRK20.88331644
49MARK20.87759477
50MAP3K20.87734346
51STK240.87206248
52ACVR1B0.85934914
53PTK20.85852486
54MAP3K110.85342878
55JAK10.85251829
56MAP2K20.81225443
57MAPK150.80021541
58MATK0.79992943
59DAPK20.79238965
60DDR20.76509481
61CAMK2G0.72966761
62PHKG10.71669902
63PHKG20.71669902
64OXSR10.71234694
65MAP2K10.70797548
66TBK10.70307172
67DYRK1B0.69713370
68HIPK20.69042954
69PRKG20.68823271
70FGFR30.68209351
71RIPK40.68021912
72PRKCZ0.66987706
73MAP3K60.65620619
74IRAK10.65113385
75STK380.62276001
76CHUK0.59020052
77KDR0.58865374
78GSK3A0.58564297
79MAP3K140.58125313
80MAP3K10.57447509
81MAPK40.56301636
82ICK0.54847520
83PRKAA10.53577192
84TESK10.52402825
85PRKACG0.52064034
86MAP4K10.50928296
87NEK60.50083086
88KSR20.48839190
89MST40.47259786
90PDPK10.47196031
91YES10.46316398
92CSK0.45952628
93RPS6KA20.45876334
94PRKD20.45508393
95IRAK30.45458731
96PIK3CA0.45246299
97RPS6KB20.45055192
98EPHB20.44801063
99BMX0.43243132
100MUSK0.42436280
101SGK30.42039723
102NUAK10.40705832
103PAK30.40529367
104MAP3K50.39166714
105PKN10.38745447
106AKT30.36834254
107TAOK10.35183539
108MAPK120.35156022
109BCR0.35147329
110TNK20.34958329
111EGFR0.33685372
112GRK10.33237590
113RET0.32976324
114SRC0.32724781
115PDGFRA0.32371042
116PRKCQ0.32254099
117PINK10.31531583
118IGF1R0.31449125
119CDK90.30711374
120PRKD10.30253816
121LMTK20.30166679
122MAPKAPK20.29338715
123ROCK10.29064877
124TGFBR20.28785210
125NLK0.27890736
126MYLK0.27634206
127GRK50.27437392
128MTOR0.26795181
129TAOK20.26598983
130EEF2K0.26137658
131PTK2B0.26107000
132STK30.25507048
133TRPM70.25354270
134MAPK70.24877600
135LATS20.24762307
136MAP3K130.23986963
137CDK40.22977018
138RPS6KL10.22088391
139RPS6KC10.22088391
140MAPKAPK30.20911131
141PRKCA0.20847366
142LRRK20.20281643
143IKBKE0.20031417
144PDK10.19760035

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.85025573
2Nitrogen metabolism_Homo sapiens_hsa009103.14786515
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.07917717
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.96084891
5Complement and coagulation cascades_Homo sapiens_hsa046102.90957761
6Arginine biosynthesis_Homo sapiens_hsa002202.90601567
7Tryptophan metabolism_Homo sapiens_hsa003802.78738879
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61841616
9Fatty acid degradation_Homo sapiens_hsa000712.50311968
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.38880674
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37273427
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.23742087
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.14212710
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.08784994
15Butanoate metabolism_Homo sapiens_hsa006502.07838220
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.04194952
17Peroxisome_Homo sapiens_hsa041462.03101838
18Chemical carcinogenesis_Homo sapiens_hsa052041.98845829
19Histidine metabolism_Homo sapiens_hsa003401.95684762
20Sulfur metabolism_Homo sapiens_hsa009201.86002949
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.85494110
22PPAR signaling pathway_Homo sapiens_hsa033201.83141661
23Propanoate metabolism_Homo sapiens_hsa006401.82680495
24Caffeine metabolism_Homo sapiens_hsa002321.82308830
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.80482120
26Retinol metabolism_Homo sapiens_hsa008301.74244583
27Fat digestion and absorption_Homo sapiens_hsa049751.69799548
28Pancreatic secretion_Homo sapiens_hsa049721.67394349
29Fatty acid metabolism_Homo sapiens_hsa012121.66773277
30beta-Alanine metabolism_Homo sapiens_hsa004101.66501543
31Staphylococcus aureus infection_Homo sapiens_hsa051501.59669975
32Phenylalanine metabolism_Homo sapiens_hsa003601.58537739
33Bile secretion_Homo sapiens_hsa049761.56498361
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.56355530
35Tyrosine metabolism_Homo sapiens_hsa003501.56075482
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55262217
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.52503853
38Selenocompound metabolism_Homo sapiens_hsa004501.50111090
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.50061175
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46968580
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43664667
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.41072990
43Other glycan degradation_Homo sapiens_hsa005111.40928479
44Tight junction_Homo sapiens_hsa045301.35201739
45Vitamin B6 metabolism_Homo sapiens_hsa007501.34199564
46Folate biosynthesis_Homo sapiens_hsa007901.33057644
47Starch and sucrose metabolism_Homo sapiens_hsa005001.32410135
48Fatty acid elongation_Homo sapiens_hsa000621.28432319
49ECM-receptor interaction_Homo sapiens_hsa045121.27979029
50Pyruvate metabolism_Homo sapiens_hsa006201.27096340
51ABC transporters_Homo sapiens_hsa020101.22672722
52Salivary secretion_Homo sapiens_hsa049701.17803312
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.11014458
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10864073
55Vitamin digestion and absorption_Homo sapiens_hsa049771.08882503
56Carbon metabolism_Homo sapiens_hsa012001.05294682
57Biosynthesis of amino acids_Homo sapiens_hsa012301.03850822
58Notch signaling pathway_Homo sapiens_hsa043301.00294677
59Vibrio cholerae infection_Homo sapiens_hsa051100.99829804
60Sulfur relay system_Homo sapiens_hsa041220.99248707
61Steroid biosynthesis_Homo sapiens_hsa001000.99115054
62Sphingolipid metabolism_Homo sapiens_hsa006000.98894406
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.98090987
64Taste transduction_Homo sapiens_hsa047420.94290133
65Lysosome_Homo sapiens_hsa041420.94076182
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.93525258
67Asthma_Homo sapiens_hsa053100.91601377
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91548190
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90322335
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.90048928
71Glutathione metabolism_Homo sapiens_hsa004800.87068120
72Prion diseases_Homo sapiens_hsa050200.84093193
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.83722541
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82005870
75Arginine and proline metabolism_Homo sapiens_hsa003300.81315605
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79155548
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77957790
78Circadian rhythm_Homo sapiens_hsa047100.77556105
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.77031745
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73780808
81Lysine degradation_Homo sapiens_hsa003100.71968638
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71738634
83Adherens junction_Homo sapiens_hsa045200.70095274
84Glycerolipid metabolism_Homo sapiens_hsa005610.69986772
85Choline metabolism in cancer_Homo sapiens_hsa052310.68847624
86Gastric acid secretion_Homo sapiens_hsa049710.68648479
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67405093
88Collecting duct acid secretion_Homo sapiens_hsa049660.65899852
89Allograft rejection_Homo sapiens_hsa053300.65169388
90Autoimmune thyroid disease_Homo sapiens_hsa053200.62729345
91Graft-versus-host disease_Homo sapiens_hsa053320.62679820
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61699857
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61367205
94Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61324048
95GnRH signaling pathway_Homo sapiens_hsa049120.61143212
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60125563
97Olfactory transduction_Homo sapiens_hsa047400.60083718
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57250284
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56731657
100Type I diabetes mellitus_Homo sapiens_hsa049400.56060193
101Linoleic acid metabolism_Homo sapiens_hsa005910.54973779
102One carbon pool by folate_Homo sapiens_hsa006700.53421516
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53079287
104Platelet activation_Homo sapiens_hsa046110.52948739
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52523615
106Dorso-ventral axis formation_Homo sapiens_hsa043200.52150205
107Pentose phosphate pathway_Homo sapiens_hsa000300.51926527
108Insulin secretion_Homo sapiens_hsa049110.50238536
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47953773
110Metabolic pathways_Homo sapiens_hsa011000.42959661
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42421374
112Renin secretion_Homo sapiens_hsa049240.41436934
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41229431
114Fatty acid biosynthesis_Homo sapiens_hsa000610.40824376
115Galactose metabolism_Homo sapiens_hsa000520.39124605
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.38107088
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37574066
118Focal adhesion_Homo sapiens_hsa045100.36291190
119Pertussis_Homo sapiens_hsa051330.35406046
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35044046
121Dilated cardiomyopathy_Homo sapiens_hsa054140.34325559
122Fructose and mannose metabolism_Homo sapiens_hsa000510.30348643
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28824224
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.27512274
125Insulin resistance_Homo sapiens_hsa049310.26087711
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.18867090
127Mineral absorption_Homo sapiens_hsa049780.14668272
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.12999654
129Glucagon signaling pathway_Homo sapiens_hsa049220.06057707
130Arachidonic acid metabolism_Homo sapiens_hsa005900.03073328
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.02421979
132Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.02115315
133Ether lipid metabolism_Homo sapiens_hsa005650.01293124
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1452000
135Insulin signaling pathway_Homo sapiens_hsa04910-0.1277056
136Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1175251
137Protein digestion and absorption_Homo sapiens_hsa04974-0.1156218
138Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0964601
139Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0960398
140Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0871317
141Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0851521
142African trypanosomiasis_Homo sapiens_hsa05143-0.0809001
143Hepatitis C_Homo sapiens_hsa05160-0.0481607
144Amoebiasis_Homo sapiens_hsa05146-0.0435880
145Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0416541
146Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0323860
147Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0213450
148AMPK signaling pathway_Homo sapiens_hsa04152-0.0165114
149Renin-angiotensin system_Homo sapiens_hsa04614-0.0142683
150Bladder cancer_Homo sapiens_hsa05219-0.0117633

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