CAPN6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skeletal muscle contraction (GO:0003009)6.81326676
2actin-mediated cell contraction (GO:0070252)6.46085680
3embryonic skeletal joint morphogenesis (GO:0060272)5.65190002
4cartilage development involved in endochondral bone morphogenesis (GO:0060351)5.43291800
5chondrocyte development (GO:0002063)5.28300073
6mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)5.24676137
7negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.99421935
8actin filament-based movement (GO:0030048)4.98251000
9bone trabecula formation (GO:0060346)4.77629012
10regulation of skeletal muscle contraction (GO:0014819)4.65883743
11muscle cell fate commitment (GO:0042693)4.62589665
12notochord development (GO:0030903)4.52418708
13collagen fibril organization (GO:0030199)4.51827882
14somite development (GO:0061053)4.50565869
15metanephric mesenchyme development (GO:0072075)4.49294004
16cell proliferation involved in metanephros development (GO:0072203)4.45024745
17outer ear morphogenesis (GO:0042473)4.34773030
18chondrocyte proliferation (GO:0035988)4.32072056
19negative regulation of potassium ion transmembrane transport (GO:1901380)4.30878001
20paraxial mesoderm development (GO:0048339)4.26821047
21mesenchyme morphogenesis (GO:0072132)4.22006839
22kidney mesenchyme development (GO:0072074)4.21555239
23sarcomere organization (GO:0045214)4.16923864
24mesenchymal cell proliferation (GO:0010463)4.10163437
25myoblast fusion (GO:0007520)4.07090805
26cardiac myofibril assembly (GO:0055003)4.02250843
27regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.94408132
28cell proliferation involved in kidney development (GO:0072111)3.93109692
29striated muscle contraction (GO:0006941)3.90827638
30regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.80986922
31sarcoplasmic reticulum calcium ion transport (GO:0070296)3.77797073
32positive regulation of myoblast differentiation (GO:0045663)3.75071500
33negative regulation of chondrocyte differentiation (GO:0032331)3.71896212
34cornea development in camera-type eye (GO:0061303)3.68683854
35mesenchymal to epithelial transition (GO:0060231)3.68465338
36planar cell polarity pathway involved in neural tube closure (GO:0090179)3.67802299
37regulation of transforming growth factor beta2 production (GO:0032909)3.67577715
38mesonephros development (GO:0001823)3.67087544
39regulation of heart morphogenesis (GO:2000826)3.66163163
40response to inactivity (GO:0014854)3.66065579
41organ induction (GO:0001759)3.62167904
42skeletal muscle fiber development (GO:0048741)3.59734976
43regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.58279044
44lateral sprouting from an epithelium (GO:0060601)3.55057504
45regulation of mesenchymal cell apoptotic process (GO:2001053)3.54430931
46mesenchymal cell differentiation involved in renal system development (GO:2001012)3.52624146
47mesenchymal cell differentiation involved in kidney development (GO:0072161)3.52624146
48regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.48927344
49middle ear morphogenesis (GO:0042474)3.47778684
50estrogen biosynthetic process (GO:0006703)3.47696617
51convergent extension (GO:0060026)3.45286363
52endocardial cushion morphogenesis (GO:0003203)3.45029356
53actomyosin structure organization (GO:0031032)3.43174079
54embryonic forelimb morphogenesis (GO:0035115)3.42874349
55branching involved in ureteric bud morphogenesis (GO:0001658)3.39044763
56syncytium formation by plasma membrane fusion (GO:0000768)3.38457644
57myotube cell development (GO:0014904)3.38142303
58positive regulation of myotube differentiation (GO:0010831)3.37402434
59cartilage condensation (GO:0001502)3.37294469
60cell aggregation (GO:0098743)3.37294469
61embryonic cranial skeleton morphogenesis (GO:0048701)3.36873691
62proximal/distal pattern formation (GO:0009954)3.36123906
63regulation of non-canonical Wnt signaling pathway (GO:2000050)3.35034515
64negative regulation of cartilage development (GO:0061037)3.34263170
65positive regulation of cartilage development (GO:0061036)3.33144909
66plasma membrane repair (GO:0001778)3.32301216
67insulin-like growth factor receptor signaling pathway (GO:0048009)3.32280084
68embryonic camera-type eye development (GO:0031076)3.31973100
69regulation of organ formation (GO:0003156)3.31947236
70mesenchymal cell differentiation (GO:0048762)3.30624283
71head development (GO:0060322)3.29951967
72sequestering of extracellular ligand from receptor (GO:0035581)3.28159407
73hippo signaling (GO:0035329)3.27516045
74positive regulation of chondrocyte differentiation (GO:0032332)3.27447819
75G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.26436831
76syncytium formation (GO:0006949)3.26170719
77body morphogenesis (GO:0010171)3.26087059
78mesenchyme development (GO:0060485)3.24026657
79embryonic digit morphogenesis (GO:0042733)3.22929543
80forelimb morphogenesis (GO:0035136)3.22003728
81regulation of chondrocyte differentiation (GO:0032330)3.21764151
82cartilage development (GO:0051216)3.21000630
83craniofacial suture morphogenesis (GO:0097094)3.20914242
84negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.20490136
85positive regulation of hormone biosynthetic process (GO:0046886)3.19581492
86peripheral nervous system axon ensheathment (GO:0032292)3.19161479
87myelination in peripheral nervous system (GO:0022011)3.19161479
88negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.18228553
89axon extension involved in axon guidance (GO:0048846)3.17460972
90neuron projection extension involved in neuron projection guidance (GO:1902284)3.17460972
91hindlimb morphogenesis (GO:0035137)3.15886815
92negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.15625095
93embryonic skeletal system morphogenesis (GO:0048704)3.15392326
94embryonic appendage morphogenesis (GO:0035113)3.13872731
95embryonic limb morphogenesis (GO:0030326)3.13872731
96uterus development (GO:0060065)3.13595006
97regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.13232529
98negative regulation of striated muscle cell apoptotic process (GO:0010664)3.13215021
99metanephros development (GO:0001656)3.11438292
100regulation of cartilage development (GO:0061035)3.07491705
101regulation of branching involved in ureteric bud morphogenesis (GO:0090189)3.06816802
102myofibril assembly (GO:0030239)3.05179340
103cochlea morphogenesis (GO:0090103)3.04400019
104lung-associated mesenchyme development (GO:0060484)3.04061401
105limb morphogenesis (GO:0035108)3.00987892
106appendage morphogenesis (GO:0035107)3.00987892
107chondrocyte differentiation (GO:0002062)3.00576784
108positive regulation of mesenchymal cell proliferation (GO:0002053)2.99959277
109neural crest cell development (GO:0014032)2.99765370
110collagen metabolic process (GO:0032963)2.99734965
111collagen catabolic process (GO:0030574)2.99414402
112regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.99077267
113regulation of mesenchymal cell proliferation (GO:0010464)2.97779777
114positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.96936450
115limb bud formation (GO:0060174)2.94634003
116regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.94491821
117muscle organ development (GO:0007517)2.94048246
118regulation of mesonephros development (GO:0061217)2.93822778
119embryonic hindlimb morphogenesis (GO:0035116)2.93007470
120heart morphogenesis (GO:0003007)2.92712951
121mesenchymal-epithelial cell signaling (GO:0060638)2.92648773
122protein heterotrimerization (GO:0070208)2.92272494
123muscle structure development (GO:0061061)2.92036678
124keratan sulfate catabolic process (GO:0042340)2.91957614
125myoblast migration (GO:0051451)2.91193583
126endocardial cushion development (GO:0003197)2.90982261
127positive regulation of glomerulus development (GO:0090193)2.88475064
128negative regulation of glycogen biosynthetic process (GO:0045719)2.86838285
129neuronal stem cell maintenance (GO:0097150)2.86635405
130mesenchymal cell development (GO:0014031)2.85738845
131positive regulation of smoothened signaling pathway (GO:0045880)2.83993605
132actin-myosin filament sliding (GO:0033275)2.83768069
133muscle filament sliding (GO:0030049)2.83768069
134negative regulation of norepinephrine secretion (GO:0010700)2.82574911
135intraciliary transport (GO:0042073)2.80095702
136skeletal muscle tissue regeneration (GO:0043403)2.75513871
137camera-type eye morphogenesis (GO:0048593)2.73236239
138positive regulation of skeletal muscle tissue development (GO:0048643)2.72958111
139neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.72223698
140negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.71011363
141negative regulation of protein localization to cell surface (GO:2000009)2.67348328
142regulation of sarcomere organization (GO:0060297)2.64607758
143muscle fiber development (GO:0048747)2.64253038
144dorsal/ventral axis specification (GO:0009950)2.64103415
145cardiac muscle cell development (GO:0055013)2.64003260
146cellular response to BMP stimulus (GO:0071773)2.63626350
147response to BMP (GO:0071772)2.63626350
148neuron fate determination (GO:0048664)2.62670482
149regulation of myoblast differentiation (GO:0045661)2.62409358
150striated muscle cell development (GO:0055002)2.61480261
151otic vesicle formation (GO:0030916)2.60447870
152cardiac cell development (GO:0055006)2.60280423
153regulation of skeletal muscle fiber development (GO:0048742)2.59381232
154skeletal muscle tissue development (GO:0007519)2.56775691
155regulation of posttranscriptional gene silencing (GO:0060147)2.56520194
156regulation of gene silencing by miRNA (GO:0060964)2.56520194
157regulation of gene silencing by RNA (GO:0060966)2.56520194
158multicellular organismal catabolic process (GO:0044243)2.55423499
159non-canonical Wnt signaling pathway (GO:0035567)2.55396453
160muscle cell development (GO:0055001)2.53455795
161muscle contraction (GO:0006936)2.53222577
162lens morphogenesis in camera-type eye (GO:0002089)2.52425009
163Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.52290876
164limb development (GO:0060173)2.52061774
165appendage development (GO:0048736)2.52061774
166regulation of relaxation of muscle (GO:1901077)2.51543533
167response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.50978981
168calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.50969150
169dorsal/ventral neural tube patterning (GO:0021904)2.50167159
170DNA strand renaturation (GO:0000733)2.50009339
171branching involved in salivary gland morphogenesis (GO:0060445)2.49393847
172myotube differentiation (GO:0014902)2.48467663
173multicellular organismal macromolecule metabolic process (GO:0044259)2.48356844

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.51540838
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.95240506
3TP63_19390658_ChIP-ChIP_HaCaT_Human4.00603189
4WT1_19549856_ChIP-ChIP_CCG9911_Human3.39428178
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.35809181
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.32669571
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.30520338
8HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.81775766
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.71158373
10PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.60724231
11EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.56749549
12E2F7_22180533_ChIP-Seq_HELA_Human2.51374418
13EP300_21415370_ChIP-Seq_HL-1_Mouse2.40320484
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.35912572
15ISL1_27105846_Chip-Seq_CPCs_Mouse2.35143361
16POU5F1_16153702_ChIP-ChIP_HESCs_Human2.33423118
17EZH2_22144423_ChIP-Seq_EOC_Human2.28794516
18RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.23977168
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.23094509
20TAF15_26573619_Chip-Seq_HEK293_Human2.13231810
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.12623747
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.11538901
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.10956290
24CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.10731360
25FOXM1_23109430_ChIP-Seq_U2OS_Human2.09803276
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.07071814
27KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.02164114
28CBX2_27304074_Chip-Seq_ESCs_Mouse2.01936956
29WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.97514096
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.92653192
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.92653192
32ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.91868327
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77124021
34TP53_20018659_ChIP-ChIP_R1E_Mouse1.74934358
35ESR1_20079471_ChIP-ChIP_T-47D_Human1.74015292
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73115322
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71767961
38HIF1A_21447827_ChIP-Seq_MCF-7_Human1.69720690
39BRD4_25478319_ChIP-Seq_HGPS_Human1.69716714
40IGF1R_20145208_ChIP-Seq_DFB_Human1.65706549
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.64757646
42ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.64172631
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.63719516
44FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.57416978
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.55736975
46SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.52139951
47JARID2_20075857_ChIP-Seq_MESCs_Mouse1.50675878
48JARID2_20064375_ChIP-Seq_MESCs_Mouse1.50640241
49TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.50288811
50FUS_26573619_Chip-Seq_HEK293_Human1.49249370
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.48875427
52AR_21909140_ChIP-Seq_LNCAP_Human1.47227234
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.43001144
54P300_19829295_ChIP-Seq_ESCs_Human1.42173749
55DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.41955491
56TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.40860401
57SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.40755565
58E2F4_17652178_ChIP-ChIP_JURKAT_Human1.40294044
59CJUN_26792858_Chip-Seq_BT549_Human1.39924886
60GBX2_23144817_ChIP-Seq_PC3_Human1.39635527
61SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.39051647
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.35807019
63EWS_26573619_Chip-Seq_HEK293_Human1.35797682
64TP53_18474530_ChIP-ChIP_U2OS_Human1.34195166
65POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.33337700
66AR_21572438_ChIP-Seq_LNCaP_Human1.33191768
67MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.33191118
68NANOG_16153702_ChIP-ChIP_HESCs_Human1.32477850
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.31997803
70RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31165520
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30406733
72TCF3_18692474_ChIP-Seq_MESCs_Mouse1.29241393
73ZNF274_21170338_ChIP-Seq_K562_Hela1.28827502
74TCF3_18692474_ChIP-Seq_MEFs_Mouse1.28566919
75SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.28354882
76ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28346376
77TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27987984
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27590289
79RING1B_27294783_Chip-Seq_NPCs_Mouse1.26712039
80CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26326752
81ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.22988150
82GATA1_26923725_Chip-Seq_HPCs_Mouse1.22719597
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22502604
84MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22360856
85TCF4_18268006_ChIP-ChIP_LS174T_Human1.22158782
86CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.21981595
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21246324
88* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19879289
89IRF1_19129219_ChIP-ChIP_H3396_Human1.18727360
90EZH2_27294783_Chip-Seq_ESCs_Mouse1.18305802
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17656859
92TBX3_20139965_ChIP-Seq_ESCs_Mouse1.17146729
93TBX3_20139965_ChIP-Seq_MESCs_Mouse1.16266040
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15810987
95NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.15048955
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12223759
97TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11725628
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11011002
99SOX2_16153702_ChIP-ChIP_HESCs_Human1.10706443
100STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10172334
101DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10009762
102PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.09877633
103SMAD4_21799915_ChIP-Seq_A2780_Human1.09611059
104SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.07862956
105SOX9_26525672_Chip-Seq_HEART_Mouse1.07778333
106ESR1_21235772_ChIP-Seq_MCF-7_Human1.07703425
107P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07685494
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06873517
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06873517
110FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.06522497
111NANOG_21062744_ChIP-ChIP_HESCs_Human1.05326690
112TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03292145
113KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.03169340
114KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.03169340
115KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.03169340
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02205083
117ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01847976
118RING1B_27294783_Chip-Seq_ESCs_Mouse1.01058899
119ERG_21242973_ChIP-ChIP_JURKAT_Human1.00844587
120CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00618768
121AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00521870
122NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.99943378
123GATA4_21415370_ChIP-Seq_HL-1_Mouse0.99137031
124SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98830555
125KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97273747
126YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97044772
127SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.96781679
128NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96410677
129GF1B_26923725_Chip-Seq_HPCs_Mouse0.95706554
130RNF2_27304074_Chip-Seq_NSC_Mouse0.93535399
131PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92603090
132WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92438709
133NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91033645
134CLOCK_20551151_ChIP-Seq_293T_Human0.90068019
135SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89654516
136SA1_22415368_ChIP-Seq_MEFs_Mouse0.89442473
137PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89436512
138UBF1/2_26484160_Chip-Seq_HMECs_Human0.88973097
139SMAD3_21741376_ChIP-Seq_EPCs_Human0.88878758
140TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88429238
141ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87880599
142CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85634166
143SMAD_19615063_ChIP-ChIP_OVARY_Human0.85094538

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting4.44175192
2MP0003123_paternal_imprinting4.17636893
3MP0005503_abnormal_tendon_morphology4.14730276
4MP0006292_abnormal_olfactory_placode3.27814557
5MP0009250_abnormal_appendicular_skeleto3.27157551
6MP0003121_genomic_imprinting3.14786273
7MP0008438_abnormal_cutaneous_collagen3.04387634
8MP0010030_abnormal_orbit_morphology2.96369293
9MP0009053_abnormal_anal_canal2.86690334
10MP0003385_abnormal_body_wall2.75595553
11MP0003942_abnormal_urinary_system2.73875369
12MP0002282_abnormal_trachea_morphology2.63274952
13MP0004134_abnormal_chest_morphology2.37777646
14MP0004272_abnormal_basement_membrane2.33603147
15MP0000534_abnormal_ureter_morphology2.25508068
16MP0003937_abnormal_limbs/digits/tail_de2.24163398
17MP0002249_abnormal_larynx_morphology2.18496337
18MP0000537_abnormal_urethra_morphology2.15274792
19MP0000049_abnormal_middle_ear2.11274588
20MP0005508_abnormal_skeleton_morphology1.93866378
21MP0000163_abnormal_cartilage_morphology1.89546698
22MP0002115_abnormal_skeleton_extremities1.87551326
23MP0002109_abnormal_limb_morphology1.85342390
24MP0002938_white_spotting1.84949398
25MP0003941_abnormal_skin_development1.82830087
26MP0000762_abnormal_tongue_morphology1.82773679
27MP0000750_abnormal_muscle_regeneration1.82766306
28MP0002932_abnormal_joint_morphology1.82258696
29MP0003755_abnormal_palate_morphology1.81714218
30MP0001346_abnormal_lacrimal_gland1.76437397
31MP0005275_abnormal_skin_tensile1.70471429
32MP0000566_synostosis1.68577306
33MP0003935_abnormal_craniofacial_develop1.66877778
34MP0009384_cardiac_valve_regurgitation1.63981539
35MP0000428_abnormal_craniofacial_morphol1.63326617
36MP0003136_yellow_coat_color1.61017194
37MP0000759_abnormal_skeletal_muscle1.59642133
38MP0002233_abnormal_nose_morphology1.56333055
39MP0002116_abnormal_craniofacial_bone1.53700048
40MP0000733_abnormal_muscle_development1.52925420
41MP0000516_abnormal_urinary_system1.52428518
42MP0005367_renal/urinary_system_phenotyp1.52428518
43MP0002106_abnormal_muscle_physiology1.51555046
44MP0003567_abnormal_fetal_cardiomyocyte1.50506468
45MP0003115_abnormal_respiratory_system1.49189520
46MP0002113_abnormal_skeleton_development1.47994308
47MP0003705_abnormal_hypodermis_morpholog1.47398297
48MP0001299_abnormal_eye_distance/1.46048527
49MP0002108_abnormal_muscle_morphology1.45993917
50MP0002234_abnormal_pharynx_morphology1.43180028
51MP0004197_abnormal_fetal_growth/weight/1.42679974
52MP0000432_abnormal_head_morphology1.41104527
53MP0005623_abnormal_meninges_morphology1.41075524
54MP0002933_joint_inflammation1.40109887
55MP0005248_abnormal_Harderian_gland1.37931458
56MP0004084_abnormal_cardiac_muscle1.36900306
57MP0002114_abnormal_axial_skeleton1.36844606
58MP0008789_abnormal_olfactory_epithelium1.35775580
59MP0006276_abnormal_autonomic_nervous1.32157563
60MP0002896_abnormal_bone_mineralization1.30675617
61MP0006054_spinal_hemorrhage1.30622580
62MP0001270_distended_abdomen1.29392811
63MP0003279_aneurysm1.27956991
64MP0005620_abnormal_muscle_contractility1.27089805
65MP0002092_abnormal_eye_morphology1.25399360
66MP0002269_muscular_atrophy1.25045850
67MP0002111_abnormal_tail_morphology1.23420979
68MP0003315_abnormal_perineum_morphology1.22406798
69MP0001293_anophthalmia1.20351113
70MP0004233_abnormal_muscle_weight1.20330645
71MP0003787_abnormal_imprinting1.19132525
72MP0009379_abnormal_foot_pigmentation1.16568019
73MP0002089_abnormal_postnatal_growth/wei1.14699466
74MP0002163_abnormal_gland_morphology1.12721732
75MP0003119_abnormal_digestive_system1.12417232
76MP0004484_altered_response_of1.06286417
77MP0000767_abnormal_smooth_muscle1.03627820
78MP0001286_abnormal_eye_development0.98049834
79MP0004133_heterotaxia0.97928438
80MP0000747_muscle_weakness0.97785267
81MP0005394_taste/olfaction_phenotype0.95254081
82MP0005499_abnormal_olfactory_system0.95254081
83MP0003938_abnormal_ear_development0.92972495
84MP0004036_abnormal_muscle_relaxation0.92483188
85MP0004145_abnormal_muscle_electrophysio0.92183716
86MP0000751_myopathy0.92064968
87MP0005187_abnormal_penis_morphology0.90488231
88MP0000749_muscle_degeneration0.89707102
89MP0006138_congestive_heart_failure0.89261990
90MP0005390_skeleton_phenotype0.89211920
91MP0002177_abnormal_outer_ear0.88237183
92MP0005076_abnormal_cell_differentiation0.86055793
93MP0002925_abnormal_cardiovascular_devel0.85929367
94MP0002085_abnormal_embryonic_tissue0.85879808
95MP0002653_abnormal_ependyma_morphology0.84910358
96MP0005257_abnormal_intraocular_pressure0.84861706
97MP0000383_abnormal_hair_follicle0.84578612
98MP0009703_decreased_birth_body0.83130381
99MP0000026_abnormal_inner_ear0.82894419
100MP0005193_abnormal_anterior_eye0.82428248
101MP0002127_abnormal_cardiovascular_syste0.81594956
102MP0010368_abnormal_lymphatic_system0.81570308
103MP0001340_abnormal_eyelid_morphology0.81494859
104MP0010630_abnormal_cardiac_muscle0.81230930
105MP0002084_abnormal_developmental_patter0.80845798
106MP0009697_abnormal_copulation0.80644534
107MP0002837_dystrophic_cardiac_calcinosis0.80226773
108MP0005379_endocrine/exocrine_gland_phen0.80104818
109MP0005391_vision/eye_phenotype0.78718288
110MP0003137_abnormal_impulse_conducting0.78488429
111MP0000778_abnormal_nervous_system0.77671504
112MP0000647_abnormal_sebaceous_gland0.77349454
113MP0001175_abnormal_lung_morphology0.76931874
114MP0000631_abnormal_neuroendocrine_gland0.75659306
115MP0000266_abnormal_heart_morphology0.75283892
116MP0002088_abnormal_embryonic_growth/wei0.74822264
117MP0002697_abnormal_eye_size0.74078829
118MP0009672_abnormal_birth_weight0.73600580
119MP0005330_cardiomyopathy0.72977449
120MP0003283_abnormal_digestive_organ0.72870786
121MP0003984_embryonic_growth_retardation0.72843910
122MP0004087_abnormal_muscle_fiber0.71876074
123MP0000569_abnormal_digit_pigmentation0.71602622
124MP0001672_abnormal_embryogenesis/_devel0.71098105
125MP0005380_embryogenesis_phenotype0.71098105
126MP0002972_abnormal_cardiac_muscle0.70472001
127MP0008775_abnormal_heart_ventricle0.70265730
128MP0008007_abnormal_cellular_replicative0.70018049
129MP0001958_emphysema0.69938757
130MP0010678_abnormal_skin_adnexa0.69755081
131MP0003861_abnormal_nervous_system0.69576550
132MP0001849_ear_inflammation0.69495531
133MP0004215_abnormal_myocardial_fiber0.69219183
134MP0005369_muscle_phenotype0.69185211
135MP0005377_hearing/vestibular/ear_phenot0.68999430
136MP0003878_abnormal_ear_physiology0.68999430
137MP0002081_perinatal_lethality0.68317595

Predicted human phenotypes

RankGene SetZ-score
1Round ear (HP:0100830)7.50311708
2Ulnar deviation of the wrist (HP:0003049)7.07151497
3Calcaneovalgus deformity (HP:0001848)6.85417732
4Deformed tarsal bones (HP:0008119)6.29758734
5Popliteal pterygium (HP:0009756)5.52598986
6Epiphyseal dysplasia (HP:0002656)5.22354480
7Absent phalangeal crease (HP:0006109)5.14571944
8Abnormality of the calcaneus (HP:0008364)4.90209549
9Vitreoretinal degeneration (HP:0000655)4.78020111
10Malignant hyperthermia (HP:0002047)4.74143637
11Fetal akinesia sequence (HP:0001989)4.68747860
12Trismus (HP:0000211)4.55405554
13Hypoplastic ischia (HP:0003175)4.26239285
14Abnormal finger flexion creases (HP:0006143)4.22837060
15Breech presentation (HP:0001623)4.21786752
16Irregular epiphyses (HP:0010582)4.14878622
17Nemaline bodies (HP:0003798)3.96824485
18Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.90395157
19Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.86751571
20Abnormality of the ischium (HP:0003174)3.70482240
21Aplasia of the musculature (HP:0100854)3.69635921
22Neoplasm of the heart (HP:0100544)3.68328763
23Neonatal short-limb short stature (HP:0008921)3.63141093
24Muscle fiber inclusion bodies (HP:0100299)3.54935257
25Amniotic constriction ring (HP:0009775)3.50564038
26Abnormality of placental membranes (HP:0011409)3.50564038
27Protrusio acetabuli (HP:0003179)3.50133125
28Mesomelia (HP:0003027)3.43742922
29Hepatoblastoma (HP:0002884)3.35732466
30Small epiphyses (HP:0010585)3.34941540
31Metatarsus adductus (HP:0001840)3.34158655
32Short 4th metacarpal (HP:0010044)3.28171071
33Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.28171071
34Symphalangism affecting the phalanges of the hand (HP:0009773)3.21300452
35Flat capital femoral epiphysis (HP:0003370)3.20048657
36Chin dimple (HP:0010751)3.15228638
37Mild short stature (HP:0003502)3.08066203
38Delayed epiphyseal ossification (HP:0002663)3.02163838
39Cupped ribs (HP:0000887)2.99254279
40Pterygium (HP:0001059)2.94853038
41Type 2 muscle fiber atrophy (HP:0003554)2.81321261
42Abnormality of the 4th metacarpal (HP:0010012)2.80238527
43Abnormality of the pubic bones (HP:0003172)2.78321540
44Asymmetry of the thorax (HP:0001555)2.77998990
45Abnormal tarsal ossification (HP:0008369)2.75956276
46Broad thumb (HP:0011304)2.75141709
47Premature rupture of membranes (HP:0001788)2.67697185
48Rocker bottom foot (HP:0001838)2.66467598
49Broad long bones (HP:0005622)2.64176833
50Broad phalanx (HP:0006009)2.62192326
51Abnormality of the phalanges of the 2nd finger (HP:0009541)2.58674452
52Type 1 muscle fiber predominance (HP:0003803)2.57922694
53Shallow orbits (HP:0000586)2.57554658
54Exercise-induced muscle cramps (HP:0003710)2.55709878
55Metaphyseal dysplasia (HP:0100255)2.55327452
56Tarsal synostosis (HP:0008368)2.51837196
57Synostosis involving bones of the lower limbs (HP:0009138)2.51527734
58Synostosis involving bones of the feet (HP:0009140)2.51527734
59Cervical subluxation (HP:0003308)2.51382505
60Diastasis recti (HP:0001540)2.49950351
61Hip contracture (HP:0003273)2.49057480
62Osteoarthritis (HP:0002758)2.48417375
63Exercise-induced myalgia (HP:0003738)2.48234407
64Broad phalanges of the hand (HP:0009768)2.45298337
65Limited hip movement (HP:0008800)2.45253976
66Abnormal auditory evoked potentials (HP:0006958)2.43359232
67Calf muscle hypertrophy (HP:0008981)2.43232270
68Metaphyseal cupping (HP:0003021)2.42241552
69Abnormality of carpal bone ossification (HP:0006257)2.41489578
70Broad finger (HP:0001500)2.40746513
71Exostoses (HP:0100777)2.39211285
72Midline defect of the nose (HP:0004122)2.38043240
73Short 5th finger (HP:0009237)2.37360174
74Bell-shaped thorax (HP:0001591)2.37236880
75Syringomyelia (HP:0003396)2.35947779
76Spinal cord lesions (HP:0100561)2.35947779
77Ankle contracture (HP:0006466)2.34990328
78Muscle fiber atrophy (HP:0100295)2.34736901
79Abnormality of dentin (HP:0010299)2.34461847
80Myopathic facies (HP:0002058)2.34389377
81Abnormal foot bone ossification (HP:0010675)2.34294122
82Akinesia (HP:0002304)2.32780043
83Genu varum (HP:0002970)2.30528648
84Abnormality of the 2nd finger (HP:0004100)2.27568845
85Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.26843211
86Aplasia/Hypoplasia involving the musculature (HP:0001460)2.25054329
87Hyporeflexia of lower limbs (HP:0002600)2.22701110
88Broad metatarsal (HP:0001783)2.22632871
89Abnormal ossification of hand bones (HP:0005921)2.20001809
90Short middle phalanx of finger (HP:0005819)2.19384700
91Embryonal renal neoplasm (HP:0011794)2.18818983
92Nephroblastoma (Wilms tumor) (HP:0002667)2.17644319
93Fibular hypoplasia (HP:0003038)2.17587384
94Morphological abnormality of the middle ear (HP:0008609)2.17009113
95Renal duplication (HP:0000075)2.14873616
96Webbed neck (HP:0000465)2.14541870
97High anterior hairline (HP:0009890)2.13356929
98Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.13289867
99Abnormality of femoral epiphyses (HP:0006499)2.13289867
100Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.12832541
101Abnormal hand bone ossification (HP:0010660)2.11898849
102Muscle hypertrophy of the lower extremities (HP:0008968)2.11060516
103Abnormality of the middle phalanges of the toes (HP:0010183)2.10361961
104Fatigable weakness (HP:0003473)2.09853283
105Abnormality of the neuromuscular junction (HP:0003398)2.09853283
106Abnormality of the phalanges of the 5th finger (HP:0004213)2.09679704
107Broad toe (HP:0001837)2.09383659
108Short middle phalanx of the 5th finger (HP:0004220)2.08848626
109Abnormality of the calf musculature (HP:0001430)2.07863529
110Limited elbow extension (HP:0001377)2.07036346
111Abnormality of incisor morphology (HP:0011063)2.06686625
112Abnormal pancreas size (HP:0012094)2.06558508
113Broad palm (HP:0001169)2.06331902
114Long clavicles (HP:0000890)2.05152416
115Wide anterior fontanel (HP:0000260)2.04264574
116Ulnar deviation of finger (HP:0009465)2.04235000
117Flattened epiphyses (HP:0003071)2.04193045
118Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.04081117
119Absent epiphyses (HP:0010577)2.04081117
120Septo-optic dysplasia (HP:0100842)2.02157017
121Microglossia (HP:0000171)2.01612790
122Colon cancer (HP:0003003)2.01562536
123Muscle fiber splitting (HP:0003555)2.00794524
124Follicular hyperkeratosis (HP:0007502)2.00314362
125Soft skin (HP:0000977)2.00131625
126Distal arthrogryposis (HP:0005684)10.4602657
127Flat acetabular roof (HP:0003180)1.99869067
128Adducted thumb (HP:0001181)1.99722291
129Platyspondyly (HP:0000926)1.99659537
130Nasal speech (HP:0001611)1.95874560
131Vertebral clefting (HP:0008428)1.95572145
132Mildly elevated creatine phosphokinase (HP:0008180)1.94745204
133Micromelia (HP:0002983)1.94522344
134Sprengel anomaly (HP:0000912)1.94253939
135Cystic hygroma (HP:0000476)1.93587652
136Abnormality of the distal phalanx of the thumb (HP:0009617)1.93198248
137Aortic dissection (HP:0002647)1.92857927
138Absent frontal sinuses (HP:0002688)1.91881346
139Gowers sign (HP:0003391)1.91538701
140Rhizomelia (HP:0008905)1.90907631
141Dislocated radial head (HP:0003083)1.89556301
142Abnormality of the proximal phalanges of the hand (HP:0009834)1.89387107
143Abnormality of the epiphysis of the femoral head (HP:0010574)1.87163759
144Abnormality of the phalanges of the hallux (HP:0010057)1.87141562
145Difficulty running (HP:0009046)1.86903186
146Fragile skin (HP:0001030)1.86653860
147Abnormality of the radial head (HP:0003995)1.86597108
148Abnormal delivery (HP:0001787)1.85756167
149Abnormality of the parietal bone (HP:0002696)1.83278865
150Thin ribs (HP:0000883)1.83136056
151Anophthalmia (HP:0000528)1.82570091
152Cutaneous finger syndactyly (HP:0010554)1.79590173
153Abnormal vertebral ossification (HP:0100569)1.78934412
154Ulnar bowing (HP:0003031)1.77803525
155Aortic aneurysm (HP:0004942)1.76339533
156Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.75824586
157Weak cry (HP:0001612)1.75154510
158Rib fusion (HP:0000902)1.73698933
159Cutaneous syndactyly (HP:0012725)1.73036728
160Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.67352590
161Congenital diaphragmatic hernia (HP:0000776)1.62380699
162Bladder diverticulum (HP:0000015)1.59998886
163Fused cervical vertebrae (HP:0002949)1.55126680
164Joint contractures involving the joints of the feet (HP:0100492)1.54618544
165Flexion contracture of toe (HP:0005830)1.54618544
166Myotonia (HP:0002486)1.53232153
167Neonatal respiratory distress (HP:0002643)1.52493124
168Vertebral fusion (HP:0002948)1.50184016
169Hypoplastic heart (HP:0001961)1.49585627
170Mitral valve prolapse (HP:0001634)1.48382872
171Infantile muscular hypotonia (HP:0008947)1.47855390
172Mask-like facies (HP:0000298)1.43778922
173Areflexia of lower limbs (HP:0002522)1.42592854
174Bilateral microphthalmos (HP:0007633)1.42109656

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.39443230
2LATS14.62934054
3OBSCN4.24495876
4STK38L3.20548659
5EPHA43.12229591
6TRIM282.89454131
7MAP4K22.72263514
8CDK192.50400796
9MKNK12.47810464
10TNIK2.47299785
11PIK3CG2.36003894
12STK32.27082652
13TAF12.17953914
14NUAK12.07059417
15ERBB32.00756264
16EPHA31.98725642
17SIK11.92169197
18MKNK21.90686388
19PKN21.90456557
20STK241.88033331
21MAP3K101.80360704
22FGFR11.77508385
23PDGFRA1.76225828
24ZAK1.71283569
25DYRK1B1.68017850
26TRIB31.66970159
27LATS21.61350415
28WNK31.57293570
29TAOK21.55393081
30EPHA21.55265967
31EPHB21.54242111
32MAP3K31.52938242
33PASK1.51297814
34PIK3CA1.48627498
35PLK21.48007975
36AKT31.43830405
37CCNB11.40777914
38PLK31.37866113
39MOS1.35854641
40TGFBR11.32814723
41VRK21.27298404
42PRKD31.24850010
43BRSK21.24316872
44BCKDK1.23832102
45BUB11.22376158
46NLK1.21976618
47MYLK1.20310610
48CSNK1G11.15881567
49TIE11.14747013
50SRPK11.14479042
51CDK121.12773117
52WNK11.11108124
53BRD41.10065080
54CDK81.09612029
55TTN1.09595070
56TRPM71.09588211
57NME11.08493759
58CSNK1G31.03791048
59SMG11.01682419
60CLK11.01556000
61DYRK20.99736368
62MAP3K70.99482337
63NEK10.98925473
64DMPK0.98625868
65PLK40.94598068
66MET0.92983613
67PAK20.92298017
68CDC70.91724169
69DYRK1A0.91670442
70EIF2AK20.89971551
71CSNK1G20.87933078
72NEK90.87639102
73MTOR0.86541015
74PTK60.85956814
75FGFR20.85254018
76ROCK10.82759525
77EEF2K0.82237260
78RIPK10.79888165
79FGFR40.79527338
80PAK40.76132590
81RPS6KA40.75839204
82ILK0.73616836
83MUSK0.72174420
84MELK0.69161443
85BMX0.68988376
86MAP3K40.68461088
87TTK0.67930579
88LIMK10.66639184
89CDK70.66320097
90OXSR10.66064734
91ATR0.65971214
92DYRK30.64591279
93WEE10.63909802
94BCR0.62994663
95PRPF4B0.59374204
96PRKG20.59254481
97CSNK1A1L0.58544445
98ERBB20.55990900
99TYRO30.54697923
100PTK2B0.54334499
101CDC42BPA0.54181622
102PLK10.52287136
103CDK11A0.52171130
104AURKB0.51520836
105PTK20.51518958
106PDGFRB0.51045162
107ATM0.50189007
108TSSK60.49757377
109CHEK10.48431559
110CDK180.47883406
111SGK20.47789357
112CDK150.47136337
113CDK40.46353903
114BRSK10.46207254
115FLT30.45834835
116AKT10.45575098
117NEK60.44738448
118MARK20.44521716
119SIK30.43868704
120FER0.43267599
121RPS6KL10.43140671
122RPS6KC10.43140671
123CHEK20.43116805
124MAPKAPK50.42590704
125CDK10.42530745
126MAPK150.42186557
127ROCK20.41110106
128CASK0.40727257
129RPS6KB20.40009518
130CDK140.38244091
131RPS6KA20.37575914
132KSR10.37304603
133STK390.36800492
134RPS6KA60.36566891
135MAPK70.35870120
136NEK20.35288910
137STK40.35160499
138GRK10.35152558
139SGK30.34178541
140CHUK0.34038533
141CAMK1D0.33782355
142MAPK10.33507478
143VRK10.33320452
144MAPK140.32658751
145CDK90.31391664
146TESK10.31320168
147CDK20.30139747
148TGFBR20.29489844
149AKT20.28640706
150RPS6KB10.28408811

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.97261641
2Basal cell carcinoma_Homo sapiens_hsa052173.57263202
3Protein digestion and absorption_Homo sapiens_hsa049743.28611542
4Hedgehog signaling pathway_Homo sapiens_hsa043403.09511434
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.98005537
6Hippo signaling pathway_Homo sapiens_hsa043902.82277130
7TGF-beta signaling pathway_Homo sapiens_hsa043502.65431267
8Focal adhesion_Homo sapiens_hsa045102.47317266
9Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.35047053
10Cell cycle_Homo sapiens_hsa041102.26747081
11Dilated cardiomyopathy_Homo sapiens_hsa054142.19114965
12Adherens junction_Homo sapiens_hsa045202.00868513
13Proteoglycans in cancer_Homo sapiens_hsa052052.00402074
14Ribosome_Homo sapiens_hsa030101.96450097
15Wnt signaling pathway_Homo sapiens_hsa043101.88928122
16Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.82069643
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.81152772
18MicroRNAs in cancer_Homo sapiens_hsa052061.79258527
19PI3K-Akt signaling pathway_Homo sapiens_hsa041511.57657535
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56622214
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.49096129
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.47325412
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44103793
24Nitrogen metabolism_Homo sapiens_hsa009101.42971797
25Small cell lung cancer_Homo sapiens_hsa052221.42496513
26Prostate cancer_Homo sapiens_hsa052151.41636963
27Spliceosome_Homo sapiens_hsa030401.41516386
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.39797698
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37503762
30Axon guidance_Homo sapiens_hsa043601.37027961
31HTLV-I infection_Homo sapiens_hsa051661.34947941
32Sulfur relay system_Homo sapiens_hsa041221.33768399
33RNA transport_Homo sapiens_hsa030131.32776371
34mRNA surveillance pathway_Homo sapiens_hsa030151.31251238
35Tight junction_Homo sapiens_hsa045301.30455263
36Melanogenesis_Homo sapiens_hsa049161.28937231
37Pathways in cancer_Homo sapiens_hsa052001.26022528
38Propanoate metabolism_Homo sapiens_hsa006401.24621132
39Lysine degradation_Homo sapiens_hsa003101.23136018
40Melanoma_Homo sapiens_hsa052181.19346859
41Notch signaling pathway_Homo sapiens_hsa043301.16617649
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12995110
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12270058
44Phototransduction_Homo sapiens_hsa047441.11875971
45Colorectal cancer_Homo sapiens_hsa052101.08682686
46Thyroid cancer_Homo sapiens_hsa052161.06043513
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05942960
48Base excision repair_Homo sapiens_hsa034101.05933422
49Viral myocarditis_Homo sapiens_hsa054161.05150111
50RNA degradation_Homo sapiens_hsa030181.04990127
51Cardiac muscle contraction_Homo sapiens_hsa042601.04607931
52Endometrial cancer_Homo sapiens_hsa052131.01440978
53Chronic myeloid leukemia_Homo sapiens_hsa052200.99369520
54Steroid biosynthesis_Homo sapiens_hsa001000.99027425
55Arginine and proline metabolism_Homo sapiens_hsa003300.97867011
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.97816621
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96754483
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95847756
59Non-homologous end-joining_Homo sapiens_hsa034500.95821619
60Biosynthesis of amino acids_Homo sapiens_hsa012300.95466723
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94325329
62Bladder cancer_Homo sapiens_hsa052190.91715010
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91277658
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89832640
65Salivary secretion_Homo sapiens_hsa049700.83601615
66Amoebiasis_Homo sapiens_hsa051460.82308850
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80593660
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80493118
69Nucleotide excision repair_Homo sapiens_hsa034200.79229618
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78127930
71HIF-1 signaling pathway_Homo sapiens_hsa040660.78036941
72Oocyte meiosis_Homo sapiens_hsa041140.77960694
73Gastric acid secretion_Homo sapiens_hsa049710.77102968
74Mismatch repair_Homo sapiens_hsa034300.73350190
75One carbon pool by folate_Homo sapiens_hsa006700.72270382
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72253141
77p53 signaling pathway_Homo sapiens_hsa041150.71056315
78Malaria_Homo sapiens_hsa051440.69520528
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69325074
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68125841
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68008357
82Fanconi anemia pathway_Homo sapiens_hsa034600.67909083
83Homologous recombination_Homo sapiens_hsa034400.67835639
84Viral carcinogenesis_Homo sapiens_hsa052030.67404260
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.65970426
86DNA replication_Homo sapiens_hsa030300.65489530
87Rap1 signaling pathway_Homo sapiens_hsa040150.63126013
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63091612
89RNA polymerase_Homo sapiens_hsa030200.61518451
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61465849
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61155162
92Basal transcription factors_Homo sapiens_hsa030220.60817380
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60245220
94Thyroid hormone synthesis_Homo sapiens_hsa049180.59812836
95Bile secretion_Homo sapiens_hsa049760.59429100
96Oxytocin signaling pathway_Homo sapiens_hsa049210.58278219
97FoxO signaling pathway_Homo sapiens_hsa040680.57471776
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57297574
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55502038
100Pancreatic cancer_Homo sapiens_hsa052120.55492120
101Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.54910164
102Hepatitis B_Homo sapiens_hsa051610.53477807
103Carbon metabolism_Homo sapiens_hsa012000.53308394
104Glioma_Homo sapiens_hsa052140.51678859
105mTOR signaling pathway_Homo sapiens_hsa041500.51054266
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50833095
107Renin-angiotensin system_Homo sapiens_hsa046140.50574581
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50434035
109Ovarian steroidogenesis_Homo sapiens_hsa049130.49887349
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.46295128
111Olfactory transduction_Homo sapiens_hsa047400.46063654
112Insulin resistance_Homo sapiens_hsa049310.44687377
113Protein export_Homo sapiens_hsa030600.44089635
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.43871583
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43535952
116Epstein-Barr virus infection_Homo sapiens_hsa051690.42408737
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42140119
118Glucagon signaling pathway_Homo sapiens_hsa049220.41638009
119Arginine biosynthesis_Homo sapiens_hsa002200.39856821
120N-Glycan biosynthesis_Homo sapiens_hsa005100.39109293
121Renal cell carcinoma_Homo sapiens_hsa052110.38930372
122Non-small cell lung cancer_Homo sapiens_hsa052230.38401477
123Fatty acid degradation_Homo sapiens_hsa000710.38124544
124Inositol phosphate metabolism_Homo sapiens_hsa005620.38089368
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.37847142
126Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36393257
127Pyruvate metabolism_Homo sapiens_hsa006200.35580120
128Calcium signaling pathway_Homo sapiens_hsa040200.35451923
129Mineral absorption_Homo sapiens_hsa049780.35421397
130Circadian rhythm_Homo sapiens_hsa047100.35016660
131Butanoate metabolism_Homo sapiens_hsa006500.33782766
132Alcoholism_Homo sapiens_hsa050340.32611312
133Huntingtons disease_Homo sapiens_hsa050160.32464513
134Gap junction_Homo sapiens_hsa045400.31918291
135Circadian entrainment_Homo sapiens_hsa047130.31054476
136MAPK signaling pathway_Homo sapiens_hsa040100.29817430
137Vascular smooth muscle contraction_Homo sapiens_hsa042700.29103924
138Platelet activation_Homo sapiens_hsa046110.28313673
139Herpes simplex infection_Homo sapiens_hsa051680.27077934
140AMPK signaling pathway_Homo sapiens_hsa041520.26554606
141Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25549882
142TNF signaling pathway_Homo sapiens_hsa046680.25012202

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