CAPN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of relaxation of muscle (GO:1901077)7.66173430
2muscle filament sliding (GO:0030049)7.00957635
3actin-myosin filament sliding (GO:0033275)7.00957635
4lens morphogenesis in camera-type eye (GO:0002089)6.87535988
5skeletal muscle contraction (GO:0003009)6.36558946
6sarcoplasmic reticulum calcium ion transport (GO:0070296)6.25809621
7regulation of skeletal muscle contraction (GO:0014819)6.25349037
8positive regulation of synaptic transmission, dopaminergic (GO:0032226)6.24641131
9histone H3-K9 demethylation (GO:0033169)5.98156130
10ADP metabolic process (GO:0046031)5.96745160
11AMP metabolic process (GO:0046033)5.91410341
12actin-mediated cell contraction (GO:0070252)5.49189512
13visual perception (GO:0007601)5.39295513
14sensory perception of light stimulus (GO:0050953)5.31460102
15camera-type eye development (GO:0043010)5.25115469
16negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.14932351
17melanin biosynthetic process (GO:0042438)5.09461980
18positive regulation of catecholamine secretion (GO:0033605)5.06251182
19regulation of oxidative phosphorylation (GO:0002082)5.01734710
20regulation of oxidative stress-induced neuron death (GO:1903203)4.94334274
21cardiac muscle hypertrophy (GO:0003300)4.93895427
22protein refolding (GO:0042026)4.91948912
23bile acid and bile salt transport (GO:0015721)4.89296818
24skeletal muscle adaptation (GO:0043501)4.85959331
25nucleoside diphosphate biosynthetic process (GO:0009133)4.82537782
26fructose metabolic process (GO:0006000)4.78276720
27melanin metabolic process (GO:0006582)4.75944553
28striated muscle hypertrophy (GO:0014897)4.68573210
29cellular response to zinc ion (GO:0071294)4.59985585
30cytidine metabolic process (GO:0046087)4.54398344
31cytidine catabolic process (GO:0006216)4.54398344
32cytidine deamination (GO:0009972)4.54398344
33daunorubicin metabolic process (GO:0044597)4.53391898
34polyketide metabolic process (GO:0030638)4.53391898
35doxorubicin metabolic process (GO:0044598)4.53391898
36skeletal muscle fiber development (GO:0048741)4.40154114
37cardiac muscle contraction (GO:0060048)4.34145938
38eye development (GO:0001654)4.31908165
39response to mercury ion (GO:0046689)4.27661783
40actin filament-based movement (GO:0030048)4.27379830
41skeletal muscle tissue development (GO:0007519)4.21017021
42cellular response to cadmium ion (GO:0071276)4.20512300
43muscle hypertrophy (GO:0014896)4.18272915
44negative regulation of potassium ion transmembrane transport (GO:1901380)4.18194048
45pyrimidine ribonucleoside catabolic process (GO:0046133)4.14436340
46plasma membrane repair (GO:0001778)4.11267417
47secondary metabolite biosynthetic process (GO:0044550)4.07942424
48striated muscle contraction (GO:0006941)3.98919695
49carnitine shuttle (GO:0006853)3.97905761
50negative regulation of cell size (GO:0045792)3.93572269
51regulation of cellular respiration (GO:0043457)3.88538612
52negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.87867130
53adult heart development (GO:0007512)3.85415922
54* myofibril assembly (GO:0030239)3.80368035
55myotube cell development (GO:0014904)3.76432421
56purine ribonucleoside diphosphate metabolic process (GO:0009179)3.68450820
57purine nucleoside diphosphate metabolic process (GO:0009135)3.68450820
58muscle cell fate commitment (GO:0042693)3.66759079
59neuromuscular synaptic transmission (GO:0007274)3.66121426
60glycogen catabolic process (GO:0005980)3.59693309
61insulin-like growth factor receptor signaling pathway (GO:0048009)3.58756815
62regulation of hydrogen peroxide-induced cell death (GO:1903205)3.57063601
63positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.56757445
64regulation of actin filament-based movement (GO:1903115)3.56481972
65cardiac muscle hypertrophy in response to stress (GO:0014898)3.54441551
66muscle hypertrophy in response to stress (GO:0003299)3.54441551
67cardiac muscle adaptation (GO:0014887)3.54441551
68gluconeogenesis (GO:0006094)3.54348906
69negative regulation of response to reactive oxygen species (GO:1901032)3.53706368
70regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.53085723
71relaxation of muscle (GO:0090075)3.50286764
72muscle contraction (GO:0006936)3.39857209
73striated muscle cell development (GO:0055002)3.36598056
74negative regulation of muscle contraction (GO:0045932)3.36203762
75* muscle organ development (GO:0007517)3.32754632
76* sarcomere organization (GO:0045214)3.32285602
77glucan catabolic process (GO:0009251)3.32275218
78hexose biosynthetic process (GO:0019319)3.30879135
79* muscle structure development (GO:0061061)3.30516476
80NLS-bearing protein import into nucleus (GO:0006607)3.29947970
81sensory organ development (GO:0007423)3.29221813
82positive regulation of myoblast differentiation (GO:0045663)3.26593920
83fatty acid transmembrane transport (GO:1902001)3.23135295
84coenzyme catabolic process (GO:0009109)3.23012516
85negative regulation of homotypic cell-cell adhesion (GO:0034111)3.22760832
86positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.21534313
87creatine metabolic process (GO:0006600)3.21235777
88cellular response to toxic substance (GO:0097237)3.20602443
89TOR signaling (GO:0031929)3.17724455
90* muscle cell cellular homeostasis (GO:0046716)3.17724370
91positive regulation of myotube differentiation (GO:0010831)3.12629858
92regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.11641228
93skeletal muscle tissue regeneration (GO:0043403)3.10273500
94regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.10043362
95regulation of striated muscle contraction (GO:0006942)3.10027294
96response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.09828001
97regulation of Rac protein signal transduction (GO:0035020)3.09593309
98cellular polysaccharide catabolic process (GO:0044247)3.08133682
99regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.07723597
100muscle cell development (GO:0055001)3.06352331
101mitochondrion degradation (GO:0000422)3.04816637
102regulation of calcium ion transmembrane transport (GO:1903169)3.03971694
103regulation of calcium ion transmembrane transporter activity (GO:1901019)3.03971694
104activation of protein kinase B activity (GO:0032148)3.02247494
105positive regulation of chemokine secretion (GO:0090197)3.01371089
106striated muscle adaptation (GO:0014888)3.01004244
107lens development in camera-type eye (GO:0002088)24.5486235
108muscle system process (GO:0003012)2.97604651
109negative regulation of cell killing (GO:0031342)2.96594101
110negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.96594101
111microglial cell activation (GO:0001774)2.95925165
112striated muscle atrophy (GO:0014891)2.90454909
113regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.88502642
114polysaccharide catabolic process (GO:0000272)2.85681844
115keratan sulfate catabolic process (GO:0042340)2.83142003
116negative regulation of bone remodeling (GO:0046851)2.81912752
117regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.80989094
118negative regulation of tissue remodeling (GO:0034104)2.80698467
119negative regulation of granulocyte differentiation (GO:0030853)2.78968485
120cardiac myofibril assembly (GO:0055003)2.72243523
121regulation of response to osmotic stress (GO:0047484)2.69811704
122muscle organ morphogenesis (GO:0048644)2.69682827
123regulation of cell communication by electrical coupling (GO:0010649)2.68769279
124glycogen biosynthetic process (GO:0005978)2.67986000
125glucan biosynthetic process (GO:0009250)2.67986000
126regulation of platelet aggregation (GO:0090330)2.67927556
127carnitine transmembrane transport (GO:1902603)2.65281174
128regulation of sarcomere organization (GO:0060297)2.61429563
129aminoglycoside antibiotic metabolic process (GO:0030647)2.61211773
130negative regulation of bone resorption (GO:0045779)2.57502245
131response to inactivity (GO:0014854)2.55655113
132muscle fiber development (GO:0048747)2.54596373
133* actomyosin structure organization (GO:0031032)2.52675073
134regulation of gamma-delta T cell differentiation (GO:0045586)2.49867164
135maintenance of protein location in nucleus (GO:0051457)2.49504821
136glycogen metabolic process (GO:0005977)2.48035697
137negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.47983720
138histone lysine demethylation (GO:0070076)2.47469579
139negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.44240399
140cellular glucan metabolic process (GO:0006073)2.41706234
141glucan metabolic process (GO:0044042)2.41706234
142* response to muscle activity (GO:0014850)2.38621743
143* cellular response to osmotic stress (GO:0071470)2.37032651
144purine nucleotide salvage (GO:0032261)2.36470259
145muscle atrophy (GO:0014889)2.36408147
146muscle adaptation (GO:0043500)2.36316954
147regulation of alkaline phosphatase activity (GO:0010692)2.36236684
148myotube differentiation (GO:0014902)2.36130311
149negative regulation of cAMP-mediated signaling (GO:0043951)2.35892897
150carnitine transport (GO:0015879)2.35624031
151amino-acid betaine transport (GO:0015838)2.35624031
152positive regulation of histone deacetylation (GO:0031065)2.35003413
153IMP metabolic process (GO:0046040)2.34935719
154L-alpha-amino acid transmembrane transport (GO:1902475)2.34309898
155lens fiber cell development (GO:0070307)17.2339984
156lens fiber cell differentiation (GO:0070306)14.9651379

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.83089359
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.03053201
3CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.45657409
4ZNF652_21678463_ChIP-ChIP_ZR75-1_Human3.32992835
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.11895446
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.67263029
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.67263029
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.67263029
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.57247396
10TCF7_22412390_ChIP-Seq_EML_Mouse2.49543771
11EZH2_22144423_ChIP-Seq_EOC_Human2.45417766
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.34462978
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.26321290
14IKZF1_21737484_ChIP-ChIP_HCT116_Human2.16862289
15NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human2.15760854
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.12713050
17MYC_22102868_ChIP-Seq_BL_Human2.11772253
18KDM2B_26808549_Chip-Seq_SUP-B15_Human2.04388846
19SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.90161689
20ZFP281_18757296_ChIP-ChIP_E14_Mouse1.86844809
21EP300_21415370_ChIP-Seq_HL-1_Mouse1.83890147
22PCGF2_27294783_Chip-Seq_NPCs_Mouse1.77705728
23SPI1_23127762_ChIP-Seq_K562_Human1.76415840
24TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.75378473
25BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.75321513
26WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.74279396
27GBX2_23144817_ChIP-Seq_PC3_Human1.73187080
28SCL_19346495_ChIP-Seq_HPC-7_Human1.72404322
29KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.71416816
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.70673945
31ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.70040528
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.67614240
33KDM2B_26808549_Chip-Seq_DND41_Human1.67585815
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67509687
35AR_21572438_ChIP-Seq_LNCaP_Human1.66040384
36* LXR_22292898_ChIP-Seq_THP-1_Human1.64223057
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.63238117
38* ELK3_25401928_ChIP-Seq_HUVEC_Human1.62081529
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.58982862
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58417594
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58014900
42ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.57164528
43SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.56836551
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.55930421
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.55649483
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.53423166
47EGR1_19032775_ChIP-ChIP_M12_Human1.50806243
48PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.49635737
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47605175
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46161967
51KDM2B_26808549_Chip-Seq_K562_Human1.46074446
52CTCF_21964334_Chip-Seq_Bcells_Human1.45153873
53EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.43089382
54GATA1_22025678_ChIP-Seq_K562_Human1.42787510
55MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.38010561
56IRF8_27001747_Chip-Seq_BMDM_Mouse1.36939719
57CTCF_21964334_ChIP-Seq_BJAB-B_Human1.36547554
58TCF3_18692474_ChIP-Seq_MEFs_Mouse1.36343786
59TBX20_22080862_ChIP-Seq_HEART_Mouse1.35916795
60TBX20_22328084_ChIP-Seq_HEART_Mouse1.35916795
61DROSHA_22980978_ChIP-Seq_HELA_Human1.34026793
62TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33916331
63* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.32410483
64NANOG_16153702_ChIP-ChIP_HESCs_Human1.29604231
65RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29311690
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26027228
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20466026
68HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.18155630
69TBX3_20139965_ChIP-Seq_ESCs_Mouse1.17151589
70* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.16251651
71SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15917066
72TBX3_20139965_ChIP-Seq_MESCs_Mouse1.15273675
73CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13624932
74MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.13104921
75EZH2_27294783_Chip-Seq_ESCs_Mouse1.12964132
76ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11698581
77VDR_24787735_ChIP-Seq_THP-1_Human1.11437344
78GATA3_24758297_ChIP-Seq_MCF-7_Human1.09155361
79MAF_26560356_Chip-Seq_TH1_Human1.09146234
80MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08765360
81* CTCF_27219007_Chip-Seq_Bcells_Human1.08004592
82KDM2B_26808549_Chip-Seq_JURKAT_Human1.07809987
83ELF1_20517297_ChIP-Seq_JURKAT_Human1.06764816
84SMC4_20622854_ChIP-Seq_HELA_Human1.06635697
85EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06080224
86TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05817815
87SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04962947
88IGF1R_20145208_ChIP-Seq_DFB_Human1.04266749
89SA1_27219007_Chip-Seq_Bcells_Human1.04030961
90NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03329344
91CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02886642
92TP53_22127205_ChIP-Seq_IMR90_Human1.01616574
93JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00816931
94CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99793734
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99685703
96RUNX_20019798_ChIP-Seq_JUKART_Human0.99440469
97SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98166204
98GATA2_21666600_ChIP-Seq_HMVEC_Human0.98160964
99* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.97766255
100HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97155300
101ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96932903
102GATA4_21415370_ChIP-Seq_HL-1_Mouse0.96707534
103BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96687911
104VDR_21846776_ChIP-Seq_THP-1_Human0.96521607
105RAD21_21589869_ChIP-Seq_MESCs_Mouse0.95916841
106SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95828655
107ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94731447
108SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94634740
109DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93264916
110LXR_22158963_ChIP-Seq_LIVER_Mouse0.93261334
111CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92279136
112LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92123529
113ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91785509
114TCF3_18692474_ChIP-Seq_MESCs_Mouse0.90688421
115MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90539421
116DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90511197
117SMC3_22415368_ChIP-Seq_MEFs_Mouse0.90368180
118GATA1_19941827_ChIP-Seq_MEL_Mouse0.89784579
119SPI1_20517297_ChIP-Seq_HL60_Human0.89266015
120MYC_27129775_Chip-Seq_CORNEA_Mouse0.89189084
121NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.88883267
122PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88736912
123RXR_22158963_ChIP-Seq_LIVER_Mouse0.88671702
124FOXA2_19822575_ChIP-Seq_HepG2_Human0.88539718
125FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.88515722
126OCT4_20526341_ChIP-Seq_ESCs_Human0.88498695
127OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88073411
128RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87890490
129ER_23166858_ChIP-Seq_MCF-7_Human0.87761850
130CBP_21632823_ChIP-Seq_H3396_Human0.87154147
131JARID2_20075857_ChIP-Seq_MESCs_Mouse0.87114026
132RXR_22108803_ChIP-Seq_LS180_Human0.86716975
133SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.86463615
134MAF_26560356_Chip-Seq_TH2_Human0.85780259
135JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85695798
136GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.85375065
137P68_20966046_ChIP-Seq_HELA_Human0.85269769
138WDR5_24793694_ChIP-Seq_LNCAP_Human0.85018040
139OCT4_19829295_ChIP-Seq_ESCs_Human0.84976654
140NFIB_24661679_ChIP-Seq_LUNG_Mouse0.84943071
141VDR_22108803_ChIP-Seq_LS180_Human0.83935434
142UTX_26944678_Chip-Seq_JUKART_Human0.83792813
143RARB_27405468_Chip-Seq_BRAIN_Mouse0.81178739
144EZH2_18974828_ChIP-Seq_MESCs_Mouse0.80604621
145RNF2_18974828_ChIP-Seq_MESCs_Mouse0.80604621
146SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.80556282
147RNF2_27304074_Chip-Seq_ESCs_Mouse0.78731513
148EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.78512191
149* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.77333580
150TP53_20018659_ChIP-ChIP_R1E_Mouse0.76797609
151KLF5_20875108_ChIP-Seq_MESCs_Mouse0.76636809
152TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76089539
153STAT1_20625510_ChIP-Seq_HELA_Human0.75125638
154PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74879109
155* MITF_21258399_ChIP-Seq_MELANOMA_Human0.74203937
156RAC3_21632823_ChIP-Seq_H3396_Human0.74164757
157NANOG_20526341_ChIP-Seq_ESCs_Human0.73881014
158TP53_23651856_ChIP-Seq_MEFs_Mouse0.73424302

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005193_abnormal_anterior_eye6.58572819
2MP0004145_abnormal_muscle_electrophysio5.25485668
3MP0003806_abnormal_nucleotide_metabolis4.87475064
4* MP0000749_muscle_degeneration4.40928987
5MP0005451_abnormal_body_composition3.53931530
6MP0003646_muscle_fatigue3.08302218
7MP0000372_irregular_coat_pigmentation3.07305673
8MP0000747_muscle_weakness3.05724722
9MP0000751_myopathy2.95476101
10MP0002092_abnormal_eye_morphology2.92665519
11MP0005253_abnormal_eye_physiology2.87010325
12MP0005197_abnormal_uvea_morphology2.76129263
13MP0002106_abnormal_muscle_physiology2.72306731
14* MP0002269_muscular_atrophy2.59815714
15MP0003136_yellow_coat_color2.52392662
16MP0001286_abnormal_eye_development2.51451352
17MP0005171_absent_coat_pigmentation2.47497493
18* MP0000759_abnormal_skeletal_muscle2.45903289
19* MP0004087_abnormal_muscle_fiber2.28893315
20MP0004036_abnormal_muscle_relaxation2.20511677
21* MP0005369_muscle_phenotype2.11142952
22MP0002332_abnormal_exercise_endurance2.05378835
23MP0005391_vision/eye_phenotype2.04119757
24MP0002697_abnormal_eye_size10.0365839
25MP0000750_abnormal_muscle_regeneration1.91474762
26MP0004130_abnormal_muscle_cell1.88750392
27MP0005620_abnormal_muscle_contractility1.73913168
28MP0002090_abnormal_vision1.69310088
29MP0004185_abnormal_adipocyte_glucose1.64212105
30MP0003705_abnormal_hypodermis_morpholog1.60764561
31MP0006138_congestive_heart_failure1.60680012
32MP0006082_CNS_inflammation1.55496404
33MP0004381_abnormal_hair_follicle1.54887623
34MP0000733_abnormal_muscle_development1.54360047
35MP0003941_abnormal_skin_development1.52191959
36MP0008961_abnormal_basal_metabolism1.33677914
37MP0002837_dystrophic_cardiac_calcinosis1.29828740
38MP0009780_abnormal_chondrocyte_physiolo1.25299891
39MP0010368_abnormal_lymphatic_system1.24321058
40MP0009840_abnormal_foam_cell1.23896130
41MP0004233_abnormal_muscle_weight1.22473518
42MP0005666_abnormal_adipose_tissue1.19460133
43MP0000015_abnormal_ear_pigmentation1.17138934
44MP0000013_abnormal_adipose_tissue1.16931327
45MP0004084_abnormal_cardiac_muscle1.15388479
46MP0003191_abnormal_cellular_cholesterol1.14598750
47MP0005670_abnormal_white_adipose1.07304353
48MP0003252_abnormal_bile_duct1.05132539
49MP0002254_reproductive_system_inflammat1.03352351
50MP0004858_abnormal_nervous_system1.01244452
51MP0010630_abnormal_cardiac_muscle1.00901956
52MP0005408_hypopigmentation1.00309064
53MP0003172_abnormal_lysosome_physiology1.00036748
54MP0001661_extended_life_span0.99031707
55MP0003950_abnormal_plasma_membrane0.92674753
56MP0003879_abnormal_hair_cell0.90587056
57MP0008004_abnormal_stomach_pH0.90204280
58MP0001299_abnormal_eye_distance/0.88809742
59MP0008775_abnormal_heart_ventricle0.86224690
60MP0006292_abnormal_olfactory_placode0.85387095
61MP0001346_abnormal_lacrimal_gland0.84166148
62* MP0005330_cardiomyopathy0.84025791
63MP0002396_abnormal_hematopoietic_system0.81235252
64MP0005257_abnormal_intraocular_pressure0.81032736
65MP0005166_decreased_susceptibility_to0.79851767
66MP0004264_abnormal_extraembryonic_tissu0.79561342
67* MP0002108_abnormal_muscle_morphology0.76742795
68MP0003183_abnormal_peptide_metabolism0.75032918
69MP0003075_altered_response_to0.74794567
70MP0006035_abnormal_mitochondrial_morpho0.73503016
71MP0002925_abnormal_cardiovascular_devel0.72323396
72MP0002822_catalepsy0.72001137
73MP0004484_altered_response_of0.70533644
74MP0002972_abnormal_cardiac_muscle0.70444616
75MP0003656_abnormal_erythrocyte_physiolo0.70293577
76MP0001849_ear_inflammation0.69227051
77MP0005266_abnormal_metabolism0.68878596
78MP0004270_analgesia0.68339036
79MP0005409_darkened_coat_color0.67308286
80MP0005167_abnormal_blood-brain_barrier0.66955093
81MP0003045_fibrosis0.64815199
82MP0003221_abnormal_cardiomyocyte_apopto0.64116831
83MP0006036_abnormal_mitochondrial_physio0.63409551
84MP0005671_abnormal_response_to0.63214515
85MP0004272_abnormal_basement_membrane0.63012437
86MP0005375_adipose_tissue_phenotype0.62906322
87MP0002971_abnormal_brown_adipose0.62822665
88MP0000343_altered_response_to0.61033176
89MP0005248_abnormal_Harderian_gland0.60124537
90MP0003137_abnormal_impulse_conducting0.59223449
91MP0004510_myositis0.59005002
92* MP0000266_abnormal_heart_morphology0.58941114
93MP0003566_abnormal_cell_adhesion0.58752530
94MP0002653_abnormal_ependyma_morphology0.57530977
95MP0002095_abnormal_skin_pigmentation0.56381458
96MP0004085_abnormal_heartbeat0.54957805
97MP0005187_abnormal_penis_morphology0.54764147
98MP0009697_abnormal_copulation0.54068133
99MP0000920_abnormal_myelination0.53978433
100MP0009672_abnormal_birth_weight0.53512611
101MP0002877_abnormal_melanocyte_morpholog0.52668203
102MP0005174_abnormal_tail_pigmentation0.52616242
103MP0005195_abnormal_posterior_eye0.52477833
104MP0002928_abnormal_bile_duct0.51655329
105MP0003122_maternal_imprinting0.51557145
106MP0005376_homeostasis/metabolism_phenot0.50790164
107MP0003828_pulmonary_edema0.50498808
108MP0002132_abnormal_respiratory_system0.50415244
109MP0005075_abnormal_melanosome_morpholog0.50273740
110MP0003787_abnormal_imprinting0.49166668
111MP0008770_decreased_survivor_rate0.49073934
112MP0000371_diluted_coat_color0.48894256
113MP0002088_abnormal_embryonic_growth/wei0.48666873
114MP0003315_abnormal_perineum_morphology0.48414859
115MP0004134_abnormal_chest_morphology0.48373776
116MP0003984_embryonic_growth_retardation0.46864429
117MP0001915_intracranial_hemorrhage0.45809109
118MP0001614_abnormal_blood_vessel0.45647080
119MP0001984_abnormal_olfaction0.45557372
120MP0005058_abnormal_lysosome_morphology0.45046331
121MP0001905_abnormal_dopamine_level0.44099209
122MP0009703_decreased_birth_body0.44033480
123MP0005385_cardiovascular_system_phenoty0.43828723
124MP0001544_abnormal_cardiovascular_syste0.43828723
125MP0002638_abnormal_pupillary_reflex0.43158174
126MP0002078_abnormal_glucose_homeostasis0.42120823
127MP0008569_lethality_at_weaning0.41833775
128MP0005452_abnormal_adipose_tissue0.41501560
129MP0002127_abnormal_cardiovascular_syste0.41457081
130MP0001340_abnormal_eyelid_morphology0.40305250
131MP0002128_abnormal_blood_circulation0.38667308
132MP0000003_abnormal_adipose_tissue0.37832823
133MP0000049_abnormal_middle_ear0.37801832
134MP0004197_abnormal_fetal_growth/weight/0.37216104
135MP0000767_abnormal_smooth_muscle0.36195753
136MP0001784_abnormal_fluid_regulation0.36093611
137MP0002160_abnormal_reproductive_system0.35948395
138MP0004215_abnormal_myocardial_fiber0.35631532
139MP0005023_abnormal_wound_healing0.33367604
140MP0009250_abnormal_appendicular_skeleto0.33164465
141MP0001672_abnormal_embryogenesis/_devel0.32875391
142MP0005334_abnormal_fat_pad0.31233747
143MP0010234_abnormal_vibrissa_follicle0.30372287
144MP0003633_abnormal_nervous_system0.28938150
145MP0005584_abnormal_enzyme/coenzyme_acti0.28894193
146MP0002272_abnormal_nervous_system0.26731634
147MP0005165_increased_susceptibility_to0.25956870
148MP0009115_abnormal_fat_cell0.24068871
149MP0002114_abnormal_axial_skeleton0.23757029

Predicted human phenotypes

RankGene SetZ-score
1Congenital cataract (HP:0000519)6.57027789
2Amblyopia (HP:0000646)6.18275684
3Corneal dystrophy (HP:0001131)5.72070501
4Anterior segment dysgenesis (HP:0007700)4.75068019
5Muscle fiber inclusion bodies (HP:0100299)4.66539319
6Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.42417539
7Exercise-induced myalgia (HP:0003738)4.29020641
8Nemaline bodies (HP:0003798)4.19024013
9Exercise-induced muscle cramps (HP:0003710)4.17048298
10Polar cataract (HP:0010696)3.81464176
11Bulbar palsy (HP:0001283)3.61017911
12Type 1 muscle fiber predominance (HP:0003803)3.37814197
13Limb-girdle muscle atrophy (HP:0003797)3.31435938
14Spinal rigidity (HP:0003306)3.31113106
15Distal arthrogryposis (HP:0005684)3.23019464
16Foot dorsiflexor weakness (HP:0009027)3.12347764
17Abnormality of the foot musculature (HP:0001436)3.10080387
18Muscle hypertrophy of the lower extremities (HP:0008968)3.08943695
19Weak cry (HP:0001612)3.04461559
20Difficulty running (HP:0009046)3.01224109
21Nuclear cataract (HP:0100018)23.4460011
22Zonular cataract (HP:0010920)20.7711850
23Round ear (HP:0100830)2.97721386
24Myopathic facies (HP:0002058)2.90299844
25Generalized muscle weakness (HP:0003324)2.86746867
26Muscular dystrophy (HP:0003560)2.85892763
27Ulnar deviation of the wrist (HP:0003049)2.83454569
28Microcornea (HP:0000482)2.79249648
29* Abnormality of the shoulder girdle musculature (HP:0001435)2.78866547
30Calf muscle hypertrophy (HP:0008981)2.74965304
31Dilated cardiomyopathy (HP:0001644)2.67250927
32Muscle fiber splitting (HP:0003555)2.60078542
33Diaphragmatic weakness (HP:0009113)2.55287630
34Bundle branch block (HP:0011710)2.54058244
35Hyporeflexia of lower limbs (HP:0002600)2.53815346
36EMG: myopathic abnormalities (HP:0003458)2.49463106
37Resting tremor (HP:0002322)2.48222144
38Myoglobinuria (HP:0002913)2.46370719
39Iris coloboma (HP:0000612)2.46022388
40Respiratory insufficiency due to muscle weakness (HP:0002747)2.40786479
41Right ventricular cardiomyopathy (HP:0011663)2.37652048
42Malignant hyperthermia (HP:0002047)2.31624691
43Gowers sign (HP:0003391)2.25783211
44Fatigable weakness (HP:0003473)2.22113972
45Abnormality of the neuromuscular junction (HP:0003398)2.22113972
46Lipoatrophy (HP:0100578)2.21089326
47Steppage gait (HP:0003376)2.20437747
48Fetal akinesia sequence (HP:0001989)2.17176133
49Increased connective tissue (HP:0009025)2.14685392
50Muscle stiffness (HP:0003552)2.14423545
51Nonprogressive disorder (HP:0003680)2.11203172
52Waddling gait (HP:0002515)2.09683443
53Calcaneovalgus deformity (HP:0001848)2.09379511
54Distal lower limb amyotrophy (HP:0008944)2.08890321
55Long clavicles (HP:0000890)2.06549965
56Opacification of the corneal stroma (HP:0007759)1.98947252
57Rhabdomyolysis (HP:0003201)1.89646528
58Abnormality of the anterior chamber (HP:0000593)1.88685127
59Postural instability (HP:0002172)1.88139038
60Easy fatigability (HP:0003388)1.86118678
61Myotonia (HP:0002486)1.83709085
62Blue irides (HP:0000635)1.82564667
63Deformed tarsal bones (HP:0008119)1.82458949
64Ventricular fibrillation (HP:0001663)1.82021305
65Absent phalangeal crease (HP:0006109)1.81354963
66Abnormality of the calf musculature (HP:0001430)1.80880810
67Subaortic stenosis (HP:0001682)1.80118217
68Abnormality of the left ventricular outflow tract (HP:0011103)1.80118217
69Abnormality of skeletal muscle fiber size (HP:0012084)1.78974805
70Rib fusion (HP:0000902)1.75106902
71Asymmetric septal hypertrophy (HP:0001670)1.73827758
72Hip contracture (HP:0003273)1.72800663
73Urinary urgency (HP:0000012)1.72675883
74Limb-girdle muscle weakness (HP:0003325)1.72209236
75Heart block (HP:0012722)1.68480813
76Lower limb amyotrophy (HP:0007210)1.68240156
77Difficulty climbing stairs (HP:0003551)1.68019687
78Abnormal finger flexion creases (HP:0006143)1.67068851
79Nasal speech (HP:0001611)1.66508137
80Type 2 muscle fiber atrophy (HP:0003554)1.60016153
81Back pain (HP:0003418)1.59709013
82Short palpebral fissure (HP:0012745)1.58953715
83Abnormal atrioventricular conduction (HP:0005150)1.58653761
84Increased variability in muscle fiber diameter (HP:0003557)1.58615432
85EMG: neuropathic changes (HP:0003445)1.57482712
86Systemic lupus erythematosus (HP:0002725)1.57318894
87Neck muscle weakness (HP:0000467)1.56786710
88Ventricular tachycardia (HP:0004756)1.55968059
89Ventricular arrhythmia (HP:0004308)1.54325402
90Sclerocornea (HP:0000647)1.52092388
91Rapidly progressive (HP:0003678)1.51844116
92Ocular albinism (HP:0001107)1.51777304
93Hyperkalemia (HP:0002153)1.51691945
94* Proximal amyotrophy (HP:0007126)1.51532656
95Popliteal pterygium (HP:0009756)1.50391927
96White forelock (HP:0002211)1.46543725
97Generalized amyotrophy (HP:0003700)1.45717402
98Hepatoblastoma (HP:0002884)1.44209685
99Frequent falls (HP:0002359)1.44165110
100Distal lower limb muscle weakness (HP:0009053)1.43184077
101Ependymoma (HP:0002888)1.43020403
102Cerebral aneurysm (HP:0004944)1.40979399
103Muscle fiber atrophy (HP:0100295)1.40521504
104Achilles tendon contracture (HP:0001771)1.40123952
105Centrally nucleated skeletal muscle fibers (HP:0003687)1.38646769
106Posterior subcapsular cataract (HP:0007787)1.37560317
107Pelvic girdle muscle weakness (HP:0003749)1.35891565
108Mildly elevated creatine phosphokinase (HP:0008180)1.35076910
109Areflexia of lower limbs (HP:0002522)1.34388752
110Congenital primary aphakia (HP:0007707)1.31628450
111Aplasia of the musculature (HP:0100854)1.31627528
112Aplasia/Hypoplasia of the macula (HP:0008059)1.30748394
113Abnormality of the musculature of the pelvis (HP:0001469)1.29055850
114Abnormality of the hip-girdle musculature (HP:0001445)1.29055850
115Abnormality of the Achilles tendon (HP:0005109)1.28408408
116Shoulder girdle muscle weakness (HP:0003547)1.26036861
117Aplasia/Hypoplasia affecting the retina (HP:0008061)1.25606299
118Rimmed vacuoles (HP:0003805)1.23351184
119Neoplasm of the heart (HP:0100544)1.21440530
120Fused cervical vertebrae (HP:0002949)1.19746523
121Abnormality of liposaccharide metabolism (HP:0010968)1.18833336
122Abnormality of glycosphingolipid metabolism (HP:0004343)1.18833336
123Abnormality of glycolipid metabolism (HP:0010969)1.18833336
124Urethral obstruction (HP:0000796)1.18021973
125Amniotic constriction ring (HP:0009775)1.17542915
126Abnormality of placental membranes (HP:0011409)1.17542915
127Symphalangism affecting the phalanges of the hand (HP:0009773)1.17487082
128Partial duplication of thumb phalanx (HP:0009944)1.17365532
129Dislocated radial head (HP:0003083)1.16992442
130Abnormality of the calcaneus (HP:0008364)1.16671906
131Progressive muscle weakness (HP:0003323)1.15396619
132Ulnar deviation of finger (HP:0009465)1.15110788
133Paralysis (HP:0003470)1.13926616
134Abnormality of the lower motor neuron (HP:0002366)1.13455043
135Neonatal respiratory distress (HP:0002643)1.12880524
136Glomerulonephritis (HP:0000099)1.11979958
137Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.09758497
138Intestinal fistula (HP:0100819)1.08000618
139Abnormality of the radial head (HP:0003995)1.06982623
140Slender build (HP:0001533)1.06568109
141Aplasia/Hypoplasia of the lens (HP:0008063)1.06369139
142* Scapular winging (HP:0003691)1.05759790
143Bilateral microphthalmos (HP:0007633)1.05733674
144Sudden death (HP:0001699)1.05443803
145Webbed neck (HP:0000465)1.02512260

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN5.46127234
2MAP2K64.65231284
3TGFBR24.59618239
4TTN3.47702773
5MARK33.26229332
6CDK123.18040562
7PHKG23.08793514
8PHKG13.08793514
9CSF1R2.85221466
10PIK3CG2.42362391
11MAP3K72.22230318
12ERN12.07637981
13GRK52.05241424
14GRK71.97837151
15BLK1.95278421
16MAP2K31.94031058
17PAK41.87554291
18MAPK121.84264811
19NME11.79709243
20STK101.76777427
21PKN21.73599821
22SGK11.72568579
23MUSK1.66616942
24MAP3K131.61082507
25TRIB31.55716887
26MAPK151.52207511
27MAP3K11.49234058
28MAP3K101.49095439
29FLT31.39736459
30MOS1.38782070
31GRK61.32257882
32CAMK1G1.27020900
33PRKG11.21915089
34MAPK71.21612431
35LATS11.20406044
36ICK1.20347232
37MAP2K41.16276606
38ZAP701.12800699
39DMPK1.09443134
40ARAF1.09120012
41CCNB11.08603765
42CAMK41.07802753
43ADRBK21.06676896
44SIK11.06502592
45NTRK11.02118635
46WNK10.98937586
47IGF1R0.90185082
48LATS20.88130519
49CAMK1D0.87210395
50SGK20.84924655
51TYK20.84723351
52MAP3K90.82942328
53MATK0.80190500
54SGK2230.77731093
55SGK4940.77731093
56SGK30.76589425
57MAPK100.76122857
58PTK60.73569430
59INSR0.72982311
60NEK10.72341337
61KSR20.67678164
62TYRO30.67062095
63NME20.66878812
64ITK0.65740939
65PRKACB0.63785536
66MAPKAPK30.62470559
67PDGFRA0.62064578
68TIE10.61977244
69PTK2B0.61215197
70RPS6KB10.60419345
71ROCK10.59042392
72CAMK2G0.58124298
73RPS6KA30.56898438
74EEF2K0.56246312
75AKT20.56062817
76PINK10.55235680
77RIPK10.54944607
78PDPK10.54177248
79PRKAA10.53126011
80CSK0.52705997
81GRK10.50222825
82ERBB20.49980770
83HCK0.49667971
84PAK20.48683154
85PRKG20.48633285
86PKN10.47587338
87SIK20.45396832
88MAP4K10.45279667
89CDK60.45195196
90MARK20.44703683
91PRKAA20.43749275
92TTK0.43391694
93ROCK20.42930824
94PDK10.42471430
95EPHB10.42293238
96JAK10.41810033
97PRKCB0.41622766
98STK38L0.39004452
99RIPK40.38806571
100MARK10.36612563
101NEK90.36505244
102FGFR30.36157831
103PDK20.35472007
104STK380.34061047
105BCKDK0.33923410
106CDK30.32218767
107MAP3K30.32033610
108HIPK20.31933248
109MAPK110.31591350
110PRPF4B0.30698594
111JAK20.30679668
112CAMK2D0.30481457
113CAMK10.29065456
114BMPR1B0.28784474
115PRKCQ0.28567320
116MAPKAPK20.28233511
117PTK20.28108237
118MTOR0.27139570
119PRKACG0.27082221
120CAMK2B0.26522301
121TSSK60.26155398
122STK110.26086090
123TBK10.25779176
124FGR0.25092963
125TNK20.23563705
126PIK3CA0.22581515
127ADRBK10.21782072
128MAP2K70.21691000
129RPS6KA10.21572341
130LRRK20.21436061
131MAP2K10.21405813
132MAPK130.21251247
133CSNK1A1L0.21008584
134NTRK30.20501636
135RET0.20359720
136MAPK40.20093657
137IRAK20.19044957
138CAMK2A0.18982876
139SYK0.18928288
140LCK0.18850184
141TRPM70.18538823
142BRAF0.17798860
143PRKACA0.16863764
144PRKD10.15744702
145PAK10.15401590
146CDK50.15068975
147RAF10.14841220
148MELK0.14421178
149DYRK1B0.13109849
150WEE10.12616925
151MAP3K50.12421408
152CDK140.12084083
153NEK20.10777213

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.11396348
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.87984343
3Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.72364833
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.55543348
5Dilated cardiomyopathy_Homo sapiens_hsa054142.36961487
6Pentose phosphate pathway_Homo sapiens_hsa000301.96905264
7mTOR signaling pathway_Homo sapiens_hsa041501.93865825
8Glycosaminoglycan degradation_Homo sapiens_hsa005311.90877374
9Arginine biosynthesis_Homo sapiens_hsa002201.90429068
10Arginine and proline metabolism_Homo sapiens_hsa003301.85153239
11Staphylococcus aureus infection_Homo sapiens_hsa051501.81694315
12Fructose and mannose metabolism_Homo sapiens_hsa000511.79190165
13Oxytocin signaling pathway_Homo sapiens_hsa049211.76412282
14Insulin signaling pathway_Homo sapiens_hsa049101.72199928
15Galactose metabolism_Homo sapiens_hsa000521.71115277
16Insulin resistance_Homo sapiens_hsa049311.64204333
17Glucagon signaling pathway_Homo sapiens_hsa049221.62350634
18Other glycan degradation_Homo sapiens_hsa005111.60372291
19Starch and sucrose metabolism_Homo sapiens_hsa005001.56641723
20Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.53979724
21Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.51884884
22B cell receptor signaling pathway_Homo sapiens_hsa046621.45587067
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.45322061
24Cardiac muscle contraction_Homo sapiens_hsa042601.40313114
25Central carbon metabolism in cancer_Homo sapiens_hsa052301.38861439
26Circadian rhythm_Homo sapiens_hsa047101.36719684
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.34702355
28Adherens junction_Homo sapiens_hsa045201.30946906
29Adipocytokine signaling pathway_Homo sapiens_hsa049201.30744894
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.29638228
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.28522949
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.27218632
33Mineral absorption_Homo sapiens_hsa049781.26734227
34Calcium signaling pathway_Homo sapiens_hsa040201.22078922
35Osteoclast differentiation_Homo sapiens_hsa043801.21153751
36AMPK signaling pathway_Homo sapiens_hsa041521.20986519
37Regulation of autophagy_Homo sapiens_hsa041401.20651607
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.15338916
39beta-Alanine metabolism_Homo sapiens_hsa004101.14372230
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13378917
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12016462
42Olfactory transduction_Homo sapiens_hsa047401.08605607
43Longevity regulating pathway - mammal_Homo sapiens_hsa042111.08338854
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.08310223
45Prion diseases_Homo sapiens_hsa050201.06516290
46VEGF signaling pathway_Homo sapiens_hsa043701.06444266
47GnRH signaling pathway_Homo sapiens_hsa049121.06295933
48Propanoate metabolism_Homo sapiens_hsa006401.04963270
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04076936
50Fatty acid degradation_Homo sapiens_hsa000711.03605557
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.03602380
52Tyrosine metabolism_Homo sapiens_hsa003501.03273614
53cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01081776
54Chronic myeloid leukemia_Homo sapiens_hsa052200.99745234
55Focal adhesion_Homo sapiens_hsa045100.99182031
56Viral myocarditis_Homo sapiens_hsa054160.98839054
57Salivary secretion_Homo sapiens_hsa049700.98352451
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.96986029
59Regulation of actin cytoskeleton_Homo sapiens_hsa048100.93414086
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.92186454
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91179191
62Pyruvate metabolism_Homo sapiens_hsa006200.90765871
63Carbon metabolism_Homo sapiens_hsa012000.90142401
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89073385
65Renal cell carcinoma_Homo sapiens_hsa052110.88405441
66Tight junction_Homo sapiens_hsa045300.87659818
67Notch signaling pathway_Homo sapiens_hsa043300.87477160
68Circadian entrainment_Homo sapiens_hsa047130.85386676
69Platelet activation_Homo sapiens_hsa046110.84989291
70Histidine metabolism_Homo sapiens_hsa003400.84898377
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84345920
72T cell receptor signaling pathway_Homo sapiens_hsa046600.83636467
73Toxoplasmosis_Homo sapiens_hsa051450.82507453
74Phenylalanine metabolism_Homo sapiens_hsa003600.82360522
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.82358026
76Rap1 signaling pathway_Homo sapiens_hsa040150.82324600
77Melanogenesis_Homo sapiens_hsa049160.82235062
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81551358
79Acute myeloid leukemia_Homo sapiens_hsa052210.81097672
80HIF-1 signaling pathway_Homo sapiens_hsa040660.80371083
81Proteoglycans in cancer_Homo sapiens_hsa052050.79276137
82MAPK signaling pathway_Homo sapiens_hsa040100.77001765
83Alzheimers disease_Homo sapiens_hsa050100.76381251
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75208638
85Leishmaniasis_Homo sapiens_hsa051400.74966323
86Thyroid cancer_Homo sapiens_hsa052160.73582596
87Renin secretion_Homo sapiens_hsa049240.72992535
88Choline metabolism in cancer_Homo sapiens_hsa052310.71982758
89Parkinsons disease_Homo sapiens_hsa050120.71783461
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.70413236
91Nitrogen metabolism_Homo sapiens_hsa009100.69838185
92Type II diabetes mellitus_Homo sapiens_hsa049300.69648769
93Glioma_Homo sapiens_hsa052140.68865791
94FoxO signaling pathway_Homo sapiens_hsa040680.68741318
95Inositol phosphate metabolism_Homo sapiens_hsa005620.68518154
96Biosynthesis of amino acids_Homo sapiens_hsa012300.66288547
97PPAR signaling pathway_Homo sapiens_hsa033200.65581240
98Small cell lung cancer_Homo sapiens_hsa052220.65082535
99Insulin secretion_Homo sapiens_hsa049110.64280874
100Lysine degradation_Homo sapiens_hsa003100.62703628
101Long-term potentiation_Homo sapiens_hsa047200.62600697
102Vitamin B6 metabolism_Homo sapiens_hsa007500.60097574
103Pancreatic cancer_Homo sapiens_hsa052120.59572157
104Basal cell carcinoma_Homo sapiens_hsa052170.59313914
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58265821
106Complement and coagulation cascades_Homo sapiens_hsa046100.58180912
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57937028
108Colorectal cancer_Homo sapiens_hsa052100.56820697
109Pathways in cancer_Homo sapiens_hsa052000.56553468
110Pertussis_Homo sapiens_hsa051330.56274942
111Non-small cell lung cancer_Homo sapiens_hsa052230.56030676
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55220858
113Wnt signaling pathway_Homo sapiens_hsa043100.54778033
114Legionellosis_Homo sapiens_hsa051340.54497054
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53752891
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53729680
117Long-term depression_Homo sapiens_hsa047300.53549824
118Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53210531
119Gastric acid secretion_Homo sapiens_hsa049710.51814912
120Lysosome_Homo sapiens_hsa041420.51578375
121ErbB signaling pathway_Homo sapiens_hsa040120.50971498
122Endocytosis_Homo sapiens_hsa041440.50772416
123Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50100080
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49972499
125Dorso-ventral axis formation_Homo sapiens_hsa043200.49705017
126Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48272469
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47931068
128Amoebiasis_Homo sapiens_hsa051460.47679203
129Cholinergic synapse_Homo sapiens_hsa047250.44518709
130Gap junction_Homo sapiens_hsa045400.38867636
131Endometrial cancer_Homo sapiens_hsa052130.35649886
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34652320
133ABC transporters_Homo sapiens_hsa020100.33963778
134Amphetamine addiction_Homo sapiens_hsa050310.31269844
135Butanoate metabolism_Homo sapiens_hsa006500.31216820
136Oocyte meiosis_Homo sapiens_hsa041140.31048509
137cAMP signaling pathway_Homo sapiens_hsa040240.31034684
138GABAergic synapse_Homo sapiens_hsa047270.30121260
139Estrogen signaling pathway_Homo sapiens_hsa049150.28680647
140Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28157174
141Fatty acid metabolism_Homo sapiens_hsa012120.27340680
142Bile secretion_Homo sapiens_hsa049760.24568903
143Pancreatic secretion_Homo sapiens_hsa049720.23959667
144Chemical carcinogenesis_Homo sapiens_hsa052040.20458952
145Ovarian steroidogenesis_Homo sapiens_hsa049130.19953126

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