CAPN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.52438883
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.52438883
3antigen processing and presentation of endogenous antigen (GO:0019883)4.90661650
4hemidesmosome assembly (GO:0031581)4.21018945
5positive regulation of Cdc42 GTPase activity (GO:0043089)4.20562906
6positive regulation of gamma-delta T cell activation (GO:0046645)4.05337713
7regulation of gamma-delta T cell differentiation (GO:0045586)3.92127696
8regulation of water loss via skin (GO:0033561)3.73916616
9positive thymic T cell selection (GO:0045059)3.63596054
10positive regulation of histone deacetylation (GO:0031065)3.62510419
11activation of Rac GTPase activity (GO:0032863)3.57938378
12regulation of gamma-delta T cell activation (GO:0046643)3.53828786
13protein retention in ER lumen (GO:0006621)3.40689196
14focal adhesion assembly (GO:0048041)3.36315450
15cell-substrate adherens junction assembly (GO:0007045)3.36315450
16leukocyte aggregation (GO:0070486)3.36276664
17regulation of early endosome to late endosome transport (GO:2000641)3.35985443
18maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.33769700
19thymic T cell selection (GO:0045061)3.30965564
20retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.30439977
21adherens junction assembly (GO:0034333)3.28053723
22glucose catabolic process (GO:0006007)3.26158814
23establishment of skin barrier (GO:0061436)3.25274645
24epithelial cell differentiation involved in prostate gland development (GO:0060742)3.19826141
25negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.19685181
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.19297628
27negative regulation of cell killing (GO:0031342)3.19297628
28cell-substrate junction assembly (GO:0007044)3.13868707
29semaphorin-plexin signaling pathway (GO:0071526)3.09196219
30hepatocyte apoptotic process (GO:0097284)3.06189951
31JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.05274209
32Arp2/3 complex-mediated actin nucleation (GO:0034314)3.05111047
33pinocytosis (GO:0006907)3.03983164
34stress fiber assembly (GO:0043149)3.02563045
35protein localization to endosome (GO:0036010)2.96088064
36multicellular organismal water homeostasis (GO:0050891)2.94799151
37glucose 6-phosphate metabolic process (GO:0051156)2.92639380
38antigen processing and presentation via MHC class Ib (GO:0002475)2.92008676
39negative regulation of erythrocyte differentiation (GO:0045647)2.91852975
40maternal placenta development (GO:0001893)2.90058604
41regulation of interleukin-12 biosynthetic process (GO:0045075)2.89040009
42response to laminar fluid shear stress (GO:0034616)2.88474001
43positive regulation of receptor recycling (GO:0001921)2.88124942
44proline biosynthetic process (GO:0006561)2.86045113
45positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.82829312
46regulation of extracellular matrix disassembly (GO:0010715)2.82353039
47negative thymic T cell selection (GO:0045060)2.81347324
48negative T cell selection (GO:0043383)2.80176594
49negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.79274318
50dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.77383726
51apoptotic cell clearance (GO:0043277)2.75942747
52pentose-phosphate shunt (GO:0006098)2.75123637
53branching involved in mammary gland duct morphogenesis (GO:0060444)2.74218545
54T cell selection (GO:0045058)2.73606492
55skin morphogenesis (GO:0043589)2.73004547
56positive regulation of lamellipodium assembly (GO:0010592)2.72744398
57positive regulation of protein deacetylation (GO:0090312)2.70169137
58leukocyte cell-cell adhesion (GO:0007159)2.70113237
59trophectodermal cell differentiation (GO:0001829)2.69015340
60mannose metabolic process (GO:0006013)2.66986311
61desmosome organization (GO:0002934)2.64970307
62apoptotic process involved in morphogenesis (GO:0060561)2.64188270
63natural killer cell differentiation (GO:0001779)2.63451823
64planar cell polarity pathway involved in neural tube closure (GO:0090179)2.63143782
65positive T cell selection (GO:0043368)2.63070411
66modulation by symbiont of host cellular process (GO:0044068)2.60697578
67defense response to fungus (GO:0050832)2.59931571
68growth hormone receptor signaling pathway (GO:0060396)2.59088890
69actin filament bundle assembly (GO:0051017)2.59049454
70actin filament bundle organization (GO:0061572)2.59049454
71positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.58111627
72regulation of type I interferon-mediated signaling pathway (GO:0060338)2.56668933
73atrioventricular valve morphogenesis (GO:0003181)2.56329676
74negative regulation of viral release from host cell (GO:1902187)2.56199309
75negative regulation of phagocytosis (GO:0050765)2.55397219
76positive regulation of blood vessel endothelial cell migration (GO:0043536)2.54364831
77surfactant homeostasis (GO:0043129)2.52978680
78basement membrane organization (GO:0071711)2.52405252
79cytoskeletal anchoring at plasma membrane (GO:0007016)2.52302886
80positive regulation of epidermal cell differentiation (GO:0045606)2.51154477
81epithelial cell-cell adhesion (GO:0090136)2.50881283
82bundle of His cell to Purkinje myocyte communication (GO:0086069)2.50641134
83endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.46817214
84positive regulation of natural killer cell differentiation (GO:0032825)2.46718722
85cellular response to virus (GO:0098586)2.45895022
86low-density lipoprotein particle clearance (GO:0034383)2.44753090
87regulation of glucose import in response to insulin stimulus (GO:2001273)2.44623828
88positive regulation of lamellipodium organization (GO:1902745)2.44622820
89negative regulation of interleukin-12 production (GO:0032695)2.44158747
90regulation of B cell receptor signaling pathway (GO:0050855)2.43847975
91embryonic process involved in female pregnancy (GO:0060136)2.43049145
92T cell apoptotic process (GO:0070231)2.41575524
93modulation by virus of host process (GO:0019054)2.39742066
94endodermal cell differentiation (GO:0035987)2.39255034
95positive regulation of keratinocyte differentiation (GO:0045618)2.38911046
96regulation of defense response to virus by virus (GO:0050690)2.38695563
97negative regulation of fatty acid transport (GO:2000192)2.38080490
98negative regulation of cell size (GO:0045792)2.37551605
99hypotonic response (GO:0006971)2.37337283
100response to interleukin-15 (GO:0070672)2.36584236
101regulation of leukocyte degranulation (GO:0043300)2.36364705
102regulation of apoptotic process involved in morphogenesis (GO:1902337)2.36354287
103establishment of endothelial barrier (GO:0061028)2.35915480
104cell adhesion mediated by integrin (GO:0033627)2.35719997
105regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.35513751
106activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.35174697
107amyloid precursor protein metabolic process (GO:0042982)2.34909514
108Rho protein signal transduction (GO:0007266)2.34865389
109negative regulation of stress fiber assembly (GO:0051497)2.34309089
110barbed-end actin filament capping (GO:0051016)2.33297643
111amyloid precursor protein catabolic process (GO:0042987)2.33163050
112antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.32379508
113regulation of mammary gland epithelial cell proliferation (GO:0033599)2.31893014
114positive regulation of nuclease activity (GO:0032075)2.30665962
115tolerance induction (GO:0002507)2.30632203
116NADPH regeneration (GO:0006740)2.30599296
117regulation of T cell tolerance induction (GO:0002664)2.30537775
118actin nucleation (GO:0045010)2.29477199
119morphogenesis of an endothelium (GO:0003159)2.29388974
120endothelial tube morphogenesis (GO:0061154)2.29388974
121positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.29230435
122regulation of viral release from host cell (GO:1902186)2.29008424
123signal complex assembly (GO:0007172)2.28633267
124modulation by virus of host morphology or physiology (GO:0019048)2.27695067
125platelet formation (GO:0030220)2.27178187
126negative regulation of protein localization to plasma membrane (GO:1903077)2.27166614
127negative regulation of heart growth (GO:0061117)2.27083137
128negative regulation of cardiac muscle tissue growth (GO:0055022)2.27083137
129cortical actin cytoskeleton organization (GO:0030866)2.27026182
130cellular extravasation (GO:0045123)2.26386150
131water homeostasis (GO:0030104)2.26280129
132regulation of response to interferon-gamma (GO:0060330)2.26052042
133positive regulation by symbiont of host defense response (GO:0052509)2.25883448
134modulation by symbiont of host defense response (GO:0052031)2.25883448
135modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.25883448
136modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.25883448
137positive regulation by organism of defense response of other organism involved in symbiotic interact2.25883448
138modulation by symbiont of host immune response (GO:0052553)2.25883448
139vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.25437886
140positive regulation of pseudopodium assembly (GO:0031274)2.25311618
141regulation of translational termination (GO:0006449)2.24709374
142regulation of cholesterol storage (GO:0010885)2.24621739
143mesodermal cell differentiation (GO:0048333)2.24292298
144lymphocyte apoptotic process (GO:0070227)2.24127020
145response to fungus (GO:0009620)2.23716320
146positive regulation of epidermis development (GO:0045684)2.23496562
147platelet aggregation (GO:0070527)2.23122374
148positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.22564360
149regulation of cholesterol homeostasis (GO:2000188)2.22357764
150endocytic recycling (GO:0032456)2.22161113
151regulation of interferon-beta biosynthetic process (GO:0045357)2.21975552
152regulation of translational fidelity (GO:0006450)2.21952695
153peptide catabolic process (GO:0043171)2.21795855
154T cell costimulation (GO:0031295)2.21320701
155regulation of integrin activation (GO:0033623)2.20112205
156regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.19741354
157regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.19567709
158regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.19514121
159protein maturation by protein folding (GO:0022417)2.19390564
160regulation of B cell differentiation (GO:0045577)2.19341099
161membrane raft organization (GO:0031579)2.18800212
162cellular response to growth hormone stimulus (GO:0071378)2.18704652
163endothelial cell chemotaxis (GO:0035767)2.18440917
164positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.17485455
165COPI coating of Golgi vesicle (GO:0048205)2.17095817
166Golgi transport vesicle coating (GO:0048200)2.17095817
167positive regulation of B cell differentiation (GO:0045579)2.16559918
168activation of MAPKKK activity (GO:0000185)2.16400183
169mammary gland epithelial cell proliferation (GO:0033598)2.15266172
1703-UTR-mediated mRNA stabilization (GO:0070935)2.15264597
171plasma membrane repair (GO:0001778)2.14994945

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.40443660
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.25555587
3MYC_22102868_ChIP-Seq_BL_Human2.92904138
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.72608893
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.67813834
6VDR_21846776_ChIP-Seq_THP-1_Human2.64070887
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.58526152
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.11689833
9* ELK3_25401928_ChIP-Seq_HUVEC_Human2.11637541
10MAF_26560356_Chip-Seq_TH1_Human2.10723121
11* TCF7_22412390_ChIP-Seq_EML_Mouse2.08945486
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.04350788
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.02284568
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.01961040
15KDM2B_26808549_Chip-Seq_DND41_Human2.00462587
16* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.97179293
17KDM2B_26808549_Chip-Seq_SUP-B15_Human1.95426143
18UTX_26944678_Chip-Seq_JUKART_Human1.89624562
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.86683808
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86232959
21* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.85928063
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.84710010
23KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.84296358
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.83842243
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.81588497
26* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.79930531
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.79118684
28E2F7_22180533_ChIP-Seq_HELA_Human1.77534085
29* RACK7_27058665_Chip-Seq_MCF-7_Human1.75137369
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.74838315
31ZNF263_19887448_ChIP-Seq_K562_Human1.72526749
32TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72332048
33* LXR_22292898_ChIP-Seq_THP-1_Human1.71780953
34VDR_24763502_ChIP-Seq_THP-1_Human1.71385950
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70892653
36FOXM1_23109430_ChIP-Seq_U2OS_Human1.69101928
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.62386233
38MYB_26560356_Chip-Seq_TH2_Human1.60951201
39SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57334889
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.56270345
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.55735034
42SRY_22984422_ChIP-ChIP_TESTIS_Rat1.55337297
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.54104669
44ATF3_27146783_Chip-Seq_COLON_Human1.53250536
45TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.52507753
46CLOCK_20551151_ChIP-Seq_293T_Human1.51311150
47MYB_26560356_Chip-Seq_TH1_Human1.49217468
48* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46111064
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.44508008
50IRF8_21731497_ChIP-ChIP_J774_Mouse1.44159727
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43550015
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.42707297
53* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.42571232
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41108154
55IRF8_27001747_Chip-Seq_BMDM_Mouse1.40197697
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.39975645
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39816516
58RUNX_20019798_ChIP-Seq_JUKART_Human1.39094968
59MAF_26560356_Chip-Seq_TH2_Human1.37017896
60SCL_19346495_ChIP-Seq_HPC-7_Human1.36601179
61RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.36426717
62GATA1_19941826_ChIP-Seq_K562_Human1.36425456
63NCOR1_26117541_ChIP-Seq_K562_Human1.35822300
64P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35426907
65STAT4_19710469_ChIP-ChIP_TH1__Mouse1.34787659
66* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34574444
67TET1_21451524_ChIP-Seq_MESCs_Mouse1.33823402
68* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.33776526
69PPARA_22158963_ChIP-Seq_LIVER_Mouse1.33094566
70SA1_27219007_Chip-Seq_ERYTHROID_Human1.32745424
71HIF1A_21447827_ChIP-Seq_MCF-7_Human1.32402827
72SPI1_23127762_ChIP-Seq_K562_Human1.32100121
73TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31121217
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.29368452
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27515097
76TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27027457
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.26040169
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25891358
79ERG_21242973_ChIP-ChIP_JURKAT_Human1.23907265
80BP1_19119308_ChIP-ChIP_Hs578T_Human1.23549916
81* SMC4_20622854_ChIP-Seq_HELA_Human1.23510628
82FOXO3_23340844_ChIP-Seq_DLD1_Human1.22461724
83SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22432008
84* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22294545
85* GATA6_25053715_ChIP-Seq_YYC3_Human1.22062328
86* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21852181
87* KDM2B_26808549_Chip-Seq_JURKAT_Human1.19179713
88TP53_22127205_ChIP-Seq_IMR90_Human1.17894955
89CREB1_26743006_Chip-Seq_LNCaP_Human1.16984621
90NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16732403
91* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16728644
92SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16627246
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.15115829
94* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14809476
95* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.13889349
96TRIM28_21343339_ChIP-Seq_HEK293_Human1.13724305
97GATA2_19941826_ChIP-Seq_K562_Human1.12800420
98SPI1_23547873_ChIP-Seq_NB4_Human1.12689703
99* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12078192
100SOX2_27498859_Chip-Seq_STOMACH_Mouse1.11518302
101ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.11270823
102STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10304109
103RUNX1_27514584_Chip-Seq_MCF-7_Human1.10088849
104GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09296620
105CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09254004
106IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.09113933
107* TP63_22573176_ChIP-Seq_HFKS_Human1.08230600
108GATA1_22025678_ChIP-Seq_K562_Human1.07546450
109TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07091042
110PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05935317
111KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05485766
112* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05191556
113* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03290194
114UBF1/2_26484160_Chip-Seq_HMECs_Human1.03223103
115UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01919821
116* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01700993
117CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01014602
118VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00896516
119ELF1_20517297_ChIP-Seq_JURKAT_Human1.00789727
120CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00605566
121* P68_20966046_ChIP-Seq_HELA_Human1.00544717
122SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00540810
123SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00540810
124PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00393114
125DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00174410
126FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97489035
127RXR_22158963_ChIP-Seq_LIVER_Mouse0.96498467
128* BCOR_27268052_Chip-Seq_Bcells_Human0.96351078
129SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96266973
130GATA3_27048872_Chip-Seq_THYMUS_Human0.96026618
131KDM2B_26808549_Chip-Seq_K562_Human0.95582760

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.50040433
2MP0003300_gastrointestinal_ulcer3.12605104
3MP0010352_gastrointestinal_tract_polyps2.76835266
4MP0005451_abnormal_body_composition2.68568732
5MP0010234_abnormal_vibrissa_follicle2.51919066
6MP0003566_abnormal_cell_adhesion2.44593202
7MP0003303_peritoneal_inflammation2.39978025
8MP0003436_decreased_susceptibility_to2.18755702
9MP0004947_skin_inflammation2.16680086
10MP0009278_abnormal_bone_marrow2.09999173
11MP0000685_abnormal_immune_system2.07161469
12MP0008260_abnormal_autophagy2.06231218
13MP0005076_abnormal_cell_differentiation1.96474772
14MP0005275_abnormal_skin_tensile1.94769865
15MP0005409_darkened_coat_color1.90035734
16MP0002166_altered_tumor_susceptibility1.88582928
17MP0002796_impaired_skin_barrier1.83407323
18MP0003453_abnormal_keratinocyte_physiol1.81217283
19MP0004272_abnormal_basement_membrane1.78155555
20MP0005023_abnormal_wound_healing1.76680582
21MP0001873_stomach_inflammation1.74711654
22MP0003656_abnormal_erythrocyte_physiolo1.74229687
23MP0010155_abnormal_intestine_physiology1.72924217
24MP0000467_abnormal_esophagus_morphology1.69665243
25MP0004858_abnormal_nervous_system1.66405912
26MP0004185_abnormal_adipocyte_glucose1.65207205
27MP0001790_abnormal_immune_system1.64888088
28MP0005387_immune_system_phenotype1.64888088
29MP0003763_abnormal_thymus_physiology1.60572981
30MP0000678_abnormal_parathyroid_gland1.57238222
31MP0002098_abnormal_vibrissa_morphology1.56639271
32MP0001800_abnormal_humoral_immune1.55481231
33MP0005397_hematopoietic_system_phenotyp1.54785820
34MP0001545_abnormal_hematopoietic_system1.54785820
35MP0008438_abnormal_cutaneous_collagen1.50872790
36MP0005257_abnormal_intraocular_pressure1.50382407
37MP0002877_abnormal_melanocyte_morpholog1.49865015
38MP0002060_abnormal_skin_morphology1.47501465
39MP0005501_abnormal_skin_physiology1.46924827
40MP0001835_abnormal_antigen_presentation1.46199689
41MP0003191_abnormal_cellular_cholesterol1.45269148
42MP0009840_abnormal_foam_cell1.43242941
43MP0002405_respiratory_system_inflammati1.42408337
44MP0003866_abnormal_defecation1.40226612
45MP0002006_tumorigenesis1.38867138
46MP0002396_abnormal_hematopoietic_system1.38360386
47MP0002452_abnormal_antigen_presenting1.37084513
48MP0005000_abnormal_immune_tolerance1.36701499
49MP0005025_abnormal_response_to1.36102070
50MP0005083_abnormal_biliary_tract1.33556829
51MP0001849_ear_inflammation1.33236679
52MP0002398_abnormal_bone_marrow1.33127741
53MP0002420_abnormal_adaptive_immunity1.32604691
54MP0001819_abnormal_immune_cell1.31905392
55MP0006054_spinal_hemorrhage1.31042254
56MP0009333_abnormal_splenocyte_physiolog1.30801345
57MP0000858_altered_metastatic_potential1.29927224
58MP0004510_myositis1.27888109
59MP0000490_abnormal_crypts_of1.26971689
60MP0001216_abnormal_epidermal_layer1.25954314
61MP0002723_abnormal_immune_serum1.25397967
62MP0005058_abnormal_lysosome_morphology1.25048754
63MP0010307_abnormal_tumor_latency1.24832826
64MP0000465_gastrointestinal_hemorrhage1.22294067
65MP0003448_altered_tumor_morphology1.21441967
66MP0004808_abnormal_hematopoietic_stem1.21128259
67MP0009785_altered_susceptibility_to1.20576357
68* MP0005464_abnormal_platelet_physiology1.20452680
69MP0003045_fibrosis1.19993155
70MP0002722_abnormal_immune_system1.19327409
71MP0000733_abnormal_muscle_development1.19211895
72MP0002419_abnormal_innate_immunity1.19148478
73MP0004264_abnormal_extraembryonic_tissu1.18111641
74MP0000537_abnormal_urethra_morphology1.17135351
75MP0003172_abnormal_lysosome_physiology1.17048246
76MP0001845_abnormal_inflammatory_respons1.14408159
77MP0001533_abnormal_skeleton_physiology1.14218965
78MP0000762_abnormal_tongue_morphology1.14037304
79MP0000716_abnormal_immune_system1.13030800
80MP0000689_abnormal_spleen_morphology1.11708570
81MP0003941_abnormal_skin_development1.11005075
82MP0005671_abnormal_response_to1.10555852
83MP0003329_amyloid_beta_deposits1.08754802
84MP0002254_reproductive_system_inflammat1.07856891
85MP0000579_abnormal_nail_morphology1.07768362
86MP0004782_abnormal_surfactant_physiolog1.07665635
87MP0005310_abnormal_salivary_gland1.06049350
88MP0003091_abnormal_cell_migration1.05570742
89MP0005360_urolithiasis1.05414305
90MP0008961_abnormal_basal_metabolism1.03848565
91MP0002429_abnormal_blood_cell1.03006292
92MP0009931_abnormal_skin_appearance1.02273154
93MP0002933_joint_inflammation1.01661824
94MP0000566_synostosis1.00925143
95MP0004381_abnormal_hair_follicle0.97900768
96MP0006082_CNS_inflammation0.97259920
97MP0000703_abnormal_thymus_morphology0.97162969
98MP0009053_abnormal_anal_canal0.94420044
99MP0000343_altered_response_to0.94286161
100MP0000377_abnormal_hair_follicle0.93346161
101MP0001958_emphysema0.93281485
102MP0004130_abnormal_muscle_cell0.92533336
103MP0005666_abnormal_adipose_tissue0.92438685
104MP0001243_abnormal_dermal_layer0.92233895
105MP0001348_abnormal_lacrimal_gland0.91280811
106MP0000477_abnormal_intestine_morphology0.89816233
107MP0002998_abnormal_bone_remodeling0.89267642
108MP0001853_heart_inflammation0.88788150
109MP0003075_altered_response_to0.88238345
110MP0003183_abnormal_peptide_metabolism0.88195857
111MP0002089_abnormal_postnatal_growth/wei0.86473153
112MP0000750_abnormal_muscle_regeneration0.84927597
113MP0010771_integument_phenotype0.84830001
114MP0003279_aneurysm0.84412369
115MP0004087_abnormal_muscle_fiber0.83166243
116MP0005621_abnormal_cell_physiology0.81685661
117MP0005375_adipose_tissue_phenotype0.81625525
118MP0002019_abnormal_tumor_incidence0.81380215
119MP0002148_abnormal_hypersensitivity_rea0.79248255
120MP0008004_abnormal_stomach_pH0.78810302
121MP0010678_abnormal_skin_adnexa0.78735165
122MP0000609_abnormal_liver_physiology0.77555170
123MP0000003_abnormal_adipose_tissue0.77278286
124MP0002896_abnormal_bone_mineralization0.76474689
125MP0001851_eye_inflammation0.74985436
126MP0009780_abnormal_chondrocyte_physiolo0.74313922
127MP0000767_abnormal_smooth_muscle0.74061105
128MP0010630_abnormal_cardiac_muscle0.72346684
129MP0001191_abnormal_skin_condition0.72125338
130MP0003828_pulmonary_edema0.71967089
131MP0008469_abnormal_protein_level0.71652522
132MP0000627_abnormal_mammary_gland0.71507229
133MP0005165_increased_susceptibility_to0.71041190
134MP0005390_skeleton_phenotype0.70015846
135MP0000383_abnormal_hair_follicle0.66101607
136MP0001881_abnormal_mammary_gland0.64563896
137MP0004233_abnormal_muscle_weight0.64378014
138MP0000751_myopathy0.64364295
139MP0005623_abnormal_meninges_morphology0.63538972
140MP0000462_abnormal_digestive_system0.62880673

Predicted human phenotypes

RankGene SetZ-score
1Pustule (HP:0200039)3.50875176
2Eczematoid dermatitis (HP:0000976)3.37385568
3Increased connective tissue (HP:0009025)3.26911202
4Increased IgE level (HP:0003212)3.22408644
5Milia (HP:0001056)3.02005968
6Cerebral aneurysm (HP:0004944)3.01003948
7Right ventricular cardiomyopathy (HP:0011663)2.96697527
8Broad face (HP:0000283)2.83226755
9Type 1 muscle fiber predominance (HP:0003803)2.80563030
10Ulnar deviation of the wrist (HP:0003049)2.80192647
11Flat acetabular roof (HP:0003180)2.66114446
12Increased density of long bones (HP:0006392)2.63927081
13Nasal polyposis (HP:0100582)2.58685989
14Abnormality of nail color (HP:0100643)2.56639989
15Atrophic scars (HP:0001075)2.54903961
16Recurrent fungal infections (HP:0002841)2.52875798
17Hyporeflexia of lower limbs (HP:0002600)2.48333443
18Abnormality of the Achilles tendon (HP:0005109)2.46925545
19Abnormality of the nasal mucosa (HP:0000433)2.44986106
20Autoimmune thrombocytopenia (HP:0001973)2.44787782
21Pili torti (HP:0003777)2.44488147
22Vertebral compression fractures (HP:0002953)2.42846244
23Frequent falls (HP:0002359)2.40569186
24Abnormal platelet volume (HP:0011876)2.37418204
25Papilloma (HP:0012740)2.36560515
26Verrucae (HP:0200043)2.36560515
27Aortic aneurysm (HP:0004942)2.36505783
28Ulnar bowing (HP:0003031)2.35495817
29Interstitial pulmonary disease (HP:0006530)2.34944914
30Ridged nail (HP:0001807)2.34799420
31Ankle contracture (HP:0006466)2.32456979
32Thin bony cortex (HP:0002753)2.32065026
33Ankyloglossia (HP:0010296)2.31863371
34Osteolytic defects of the phalanges of the hand (HP:0009771)2.30910139
35Osteolytic defects of the hand bones (HP:0009699)2.30910139
36Abnormality of the distal phalanges of the toes (HP:0010182)2.30177772
37Chronic otitis media (HP:0000389)2.29897173
38Distal arthrogryposis (HP:0005684)2.29694581
39Myopathic facies (HP:0002058)2.29113914
40Hemorrhage of the eye (HP:0011885)2.28999186
41Recurrent abscess formation (HP:0002722)2.27657135
42Alopecia of scalp (HP:0002293)2.25529700
43Difficulty climbing stairs (HP:0003551)2.25344471
44Abnormal blistering of the skin (HP:0008066)2.24872004
45Recurrent viral infections (HP:0004429)2.23632935
46Advanced eruption of teeth (HP:0006288)2.22360129
47Cellulitis (HP:0100658)2.21825404
48Short nail (HP:0001799)2.20719625
49Natal tooth (HP:0000695)2.19663886
50Plantar hyperkeratosis (HP:0007556)2.19110103
51Increased mean platelet volume (HP:0011877)2.18878607
52Trismus (HP:0000211)2.15599328
53Protrusio acetabuli (HP:0003179)2.15435100
54Abnormality of oral frenula (HP:0000190)2.14660371
55Centrally nucleated skeletal muscle fibers (HP:0003687)2.12929888
56Muscle fiber inclusion bodies (HP:0100299)2.12271879
57Gastrointestinal inflammation (HP:0004386)2.12138473
58Polygenic inheritance (HP:0010982)2.11990142
59Inflammation of the large intestine (HP:0002037)2.11431393
60Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.11343569
61Menorrhagia (HP:0000132)2.11324719
62Spontaneous hematomas (HP:0007420)2.06515065
63Lower limb amyotrophy (HP:0007210)2.05843467
64Slender build (HP:0001533)2.05138495
65Polycythemia (HP:0001901)2.04648678
66Round ear (HP:0100830)2.03526179
67Abnormal gallbladder physiology (HP:0012438)2.01265953
68Cholecystitis (HP:0001082)2.01265953
69Onycholysis (HP:0001806)2.00936323
70Myocardial infarction (HP:0001658)2.00407312
71Difficulty running (HP:0009046)2.00014400
72Peritonitis (HP:0002586)1.99933636
73Acanthosis nigricans (HP:0000956)1.99880585
74Fragile skin (HP:0001030)1.98756111
75Mildly elevated creatine phosphokinase (HP:0008180)1.97900318
76Colitis (HP:0002583)1.97839897
77Dilatation of the ascending aorta (HP:0005111)1.97493352
78Exercise-induced muscle cramps (HP:0003710)1.95724650
79Spinal rigidity (HP:0003306)1.95419783
80Premature rupture of membranes (HP:0001788)1.94951647
81Distal lower limb amyotrophy (HP:0008944)1.94349838
82Reticulocytosis (HP:0001923)1.94303763
83Abnormal delayed hypersensitivity skin test (HP:0002963)1.94298660
84Selective tooth agenesis (HP:0001592)1.93932885
85Abnormality of the calcaneus (HP:0008364)1.93550117
86Dysostosis multiplex (HP:0000943)1.93515802
87Cervical subluxation (HP:0003308)1.93350022
88Upper limb amyotrophy (HP:0009129)1.93188176
89Distal upper limb amyotrophy (HP:0007149)1.93188176
90Petechiae (HP:0000967)1.92522472
91Elevated erythrocyte sedimentation rate (HP:0003565)1.92474480
92Purpura (HP:0000979)1.92314655
93Rectal prolapse (HP:0002035)1.91093226
94Axonal loss (HP:0003447)1.90510146
95Prolonged bleeding time (HP:0003010)1.90136245
96Recurrent bacterial skin infections (HP:0005406)1.89139808
97Thick nail (HP:0001805)1.87717639
98J-shaped sella turcica (HP:0002680)1.87687471
99Woolly hair (HP:0002224)1.87464705
100Long palpebral fissure (HP:0000637)1.87360072
101Aneurysm (HP:0002617)1.86671886
102Mitral valve prolapse (HP:0001634)1.85822417
103Hematochezia (HP:0002573)1.85319912
104T lymphocytopenia (HP:0005403)1.84907174
105Achilles tendon contracture (HP:0001771)1.84470612
106Nemaline bodies (HP:0003798)1.84456860
107Abnormality of skeletal muscle fiber size (HP:0012084)1.83359718
108Aortic dissection (HP:0002647)1.83123358
109Abnormal platelet function (HP:0011869)1.82776754
110Impaired platelet aggregation (HP:0003540)1.82776754
111Muscle fiber splitting (HP:0003555)1.82530142
112IgM deficiency (HP:0002850)1.82393420
113Ventricular tachycardia (HP:0004756)1.82361556
114Obstructive sleep apnea (HP:0002870)1.81683096
115Stridor (HP:0010307)1.81629601
116Arterial tortuosity (HP:0005116)1.81482441
117Asymmetric septal hypertrophy (HP:0001670)1.81321550
118Hand muscle atrophy (HP:0009130)1.80786617
119Fragile nails (HP:0001808)1.80510863
120Distal lower limb muscle weakness (HP:0009053)1.78815487
121Nail dystrophy (HP:0008404)1.78277639
122Skin ulcer (HP:0200042)1.78139794
123Hyperparathyroidism (HP:0000843)1.78040829
124Abnormality of macrophages (HP:0004311)1.77950803
125Abnormality of the fingertips (HP:0001211)1.77734384
126Myositis (HP:0100614)1.75766185
127Abnormal hair laboratory examination (HP:0003328)1.75628859
128Abnormality of T cell number (HP:0011839)1.75447865
129Increased cerebral lipofuscin (HP:0011813)1.75141364
130Palmoplantar hyperkeratosis (HP:0000972)1.74019819
131Palmar hyperkeratosis (HP:0010765)1.73277664
132Malnutrition (HP:0004395)1.73196469
133Vascular tortuosity (HP:0004948)1.72024291
134Blue sclerae (HP:0000592)1.71926642
135Ureteral stenosis (HP:0000071)1.70761064
136Back pain (HP:0003418)1.70074734
137Easy fatigability (HP:0003388)1.70061002
138Urticaria (HP:0001025)1.69978889
139Abnormality of T cells (HP:0002843)1.69966401
140Periodontitis (HP:0000704)1.69632879
141Disproportionate tall stature (HP:0001519)1.69501528
142Recurrent bronchitis (HP:0002837)1.68495957
143Hyperacusis (HP:0010780)1.67924706
144Poikilocytosis (HP:0004447)1.67674582
145Increased variability in muscle fiber diameter (HP:0003557)1.67543247
146Cerebral inclusion bodies (HP:0100314)1.67429734
147Erythema (HP:0010783)1.67365598
148Epistaxis (HP:0000421)1.67266117
149Bone pain (HP:0002653)1.65355033
150Hypertriglyceridemia (HP:0002155)1.64602824
151Pterygium (HP:0001059)1.64375785
152Insomnia (HP:0100785)1.62427336
153Abdominal distention (HP:0003270)1.62174555
154Urinary glycosaminoglycan excretion (HP:0003541)1.61303495
155Mucopolysacchariduria (HP:0008155)1.61303495
156Abnormality of the thoracic spine (HP:0100711)1.60810436

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.34014347
2EEF2K3.33879675
3ERN13.15987859
4MAP4K13.10426343
5SMG13.06687676
6PKN23.06643773
7TTN3.02813914
8IRAK32.45576940
9STK102.44497222
10PRPF4B2.32647695
11MAP3K102.29286811
12LRRK22.10248920
13EPHB11.90975391
14GRK61.77949310
15PTK61.75899958
16RIPK11.71556751
17NME21.69817453
18TYK21.68869463
19JAK31.64555520
20CDK121.63930079
21MAP2K31.61406757
22MET1.57387418
23FGFR41.49357552
24MAPKAPK31.43986110
25ARAF1.41835161
26CSK1.35653517
27BMX1.34535089
28ZAP701.34233368
29TRPM71.29246838
30TAOK11.28098410
31SIK11.27571667
32MST41.26424334
33PRKD21.22948416
34JAK11.20784164
35TBK11.17548815
36MAP3K111.16875158
37TAOK21.15896267
38MAP3K31.14170171
39RIPK41.12817179
40PDGFRA1.09545550
41DMPK1.09468329
42EPHB21.04206238
43RPS6KB21.03229317
44BLK1.02920071
45CDC42BPA1.02416331
46FGFR31.00891731
47ITK1.00581250
48PIM10.99203901
49MAP3K70.98917981
50PTK20.96510264
51RPS6KA40.96444769
52MAP3K130.95373189
53MAP3K80.94765892
54PAK40.93231882
55BTK0.92100550
56MAP3K60.91551583
57CDK60.90615068
58SCYL20.89840648
59TGFBR20.89732249
60EPHA20.89643841
61JAK20.88899880
62ALK0.87915815
63NTRK10.87300324
64HCK0.87095262
65FLT30.86423031
66SIK30.85292303
67TAOK30.85247140
68LATS20.84280010
69MAP2K20.83216689
70MARK20.82923585
71ICK0.82922837
72PDPK10.79622693
73LMTK20.77333456
74IRAK40.75277228
75PRKG20.72368984
76KSR20.72225887
77IKBKE0.70807521
78MST1R0.70758659
79MTOR0.70085791
80MARK30.69594466
81PIM20.69045377
82STK380.66971379
83MAP3K20.65238543
84CAMK1D0.64793539
85MAPK110.63697592
86LCK0.63629272
87LIMK10.61297915
88MATK0.61211457
89NEK20.61149418
90MAP3K90.60530412
91DDR20.60253680
92CDK40.59989071
93TESK20.59961427
94RET0.59833581
95IRAK20.59437412
96MAPKAPK20.57590033
97HIPK20.57151864
98PIK3CG0.57039700
99PDGFRB0.56885714
100SYK0.56339382
101PRKCH0.56156990
102KIT0.55305760
103STK40.55032261
104RPS6KA60.54712554
105RPS6KL10.54111421
106RPS6KC10.54111421
107MYLK0.54065242
108KDR0.53858094
109FER0.53241673
110STK30.53034236
111TESK10.53014443
112MAP3K140.52996067
113TXK0.52888413
114CSF1R0.51947075
115ILK0.51538077
116MAP3K10.51143781
117FRK0.50290947
118NEK10.49590223
119PAK20.49577018
120TNK20.49574286
121FGR0.49521647
122CHUK0.47230450
123DYRK1B0.46588942
124EPHA30.45089238
125IKBKB0.44254290
126RPS6KA20.43984488
127RPS6KA10.43439997
128BRAF0.43433399
129PRKCI0.43059917
130MAP2K10.36582582
131PRKD30.35470650
132PAK10.34032333
133PDK10.32938503
134CDK70.32775590
135ROCK20.31994843
136LATS10.29986745
137PRKD10.29920373

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.04272901
2Leukocyte transendothelial migration_Homo sapiens_hsa046701.91780281
3Chronic myeloid leukemia_Homo sapiens_hsa052201.91407526
4Acute myeloid leukemia_Homo sapiens_hsa052211.85648380
5Primary immunodeficiency_Homo sapiens_hsa053401.81194249
6Toxoplasmosis_Homo sapiens_hsa051451.74698052
7Osteoclast differentiation_Homo sapiens_hsa043801.74022524
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.72506639
9B cell receptor signaling pathway_Homo sapiens_hsa046621.70980023
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.69436264
11Antigen processing and presentation_Homo sapiens_hsa046121.51775631
12Bladder cancer_Homo sapiens_hsa052191.49478718
13Small cell lung cancer_Homo sapiens_hsa052221.47569675
14T cell receptor signaling pathway_Homo sapiens_hsa046601.41287011
15Shigellosis_Homo sapiens_hsa051311.40959305
16VEGF signaling pathway_Homo sapiens_hsa043701.40657448
17Viral myocarditis_Homo sapiens_hsa054161.39643283
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.39494584
19Pancreatic cancer_Homo sapiens_hsa052121.38612148
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.38209789
21AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.37885263
22Measles_Homo sapiens_hsa051621.37124780
23Insulin resistance_Homo sapiens_hsa049311.34748070
24mTOR signaling pathway_Homo sapiens_hsa041501.33497137
25Focal adhesion_Homo sapiens_hsa045101.33119725
26Adherens junction_Homo sapiens_hsa045201.31977355
27Proteoglycans in cancer_Homo sapiens_hsa052051.29167557
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28084099
29Hematopoietic cell lineage_Homo sapiens_hsa046401.27055633
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.26722017
31* Apoptosis_Homo sapiens_hsa042101.25844316
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.23418543
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.21165460
34Platelet activation_Homo sapiens_hsa046111.20979757
35Non-small cell lung cancer_Homo sapiens_hsa052231.20618995
36Amoebiasis_Homo sapiens_hsa051461.20415561
37Tuberculosis_Homo sapiens_hsa051521.14711895
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.13635981
39Hepatitis B_Homo sapiens_hsa051611.13448064
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.08815855
41TNF signaling pathway_Homo sapiens_hsa046681.06637466
42Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05855407
43Vibrio cholerae infection_Homo sapiens_hsa051101.04711954
44Staphylococcus aureus infection_Homo sapiens_hsa051501.04133515
45Thyroid cancer_Homo sapiens_hsa052161.03907214
46Adipocytokine signaling pathway_Homo sapiens_hsa049201.03543448
47Regulation of actin cytoskeleton_Homo sapiens_hsa048101.02869723
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02123449
49Viral carcinogenesis_Homo sapiens_hsa052031.01423273
50Caffeine metabolism_Homo sapiens_hsa002321.00804934
51Salmonella infection_Homo sapiens_hsa051320.99372820
52Neurotrophin signaling pathway_Homo sapiens_hsa047220.99280622
53Endometrial cancer_Homo sapiens_hsa052130.98828729
54Influenza A_Homo sapiens_hsa051640.98571147
55Legionellosis_Homo sapiens_hsa051340.97444391
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96495311
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.96400431
58Hepatitis C_Homo sapiens_hsa051600.96186464
59Prolactin signaling pathway_Homo sapiens_hsa049170.96028802
60ErbB signaling pathway_Homo sapiens_hsa040120.95586709
61Prion diseases_Homo sapiens_hsa050200.95242013
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95051765
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92187953
64Insulin signaling pathway_Homo sapiens_hsa049100.92166611
65ECM-receptor interaction_Homo sapiens_hsa045120.91802099
66Biosynthesis of amino acids_Homo sapiens_hsa012300.90048075
67Chemokine signaling pathway_Homo sapiens_hsa040620.88647648
68Pertussis_Homo sapiens_hsa051330.87224416
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86432492
70Malaria_Homo sapiens_hsa051440.86109466
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85573541
72Renin-angiotensin system_Homo sapiens_hsa046140.85385908
73HIF-1 signaling pathway_Homo sapiens_hsa040660.85190883
74MicroRNAs in cancer_Homo sapiens_hsa052060.83933569
75Herpes simplex infection_Homo sapiens_hsa051680.80957247
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80815418
77Lysosome_Homo sapiens_hsa041420.80691811
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.80325290
79Fat digestion and absorption_Homo sapiens_hsa049750.79836115
80GnRH signaling pathway_Homo sapiens_hsa049120.79407495
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78722928
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78634346
83HTLV-I infection_Homo sapiens_hsa051660.77945191
84Notch signaling pathway_Homo sapiens_hsa043300.77451593
85Phenylalanine metabolism_Homo sapiens_hsa003600.77183340
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.76587003
87Endocytosis_Homo sapiens_hsa041440.76549455
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.75502921
89Other glycan degradation_Homo sapiens_hsa005110.75092136
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73563366
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73227899
92FoxO signaling pathway_Homo sapiens_hsa040680.72488328
93Pentose phosphate pathway_Homo sapiens_hsa000300.71851882
94AMPK signaling pathway_Homo sapiens_hsa041520.71843651
95Choline metabolism in cancer_Homo sapiens_hsa052310.71004160
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70790197
97Inositol phosphate metabolism_Homo sapiens_hsa005620.69941165
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69708478
99p53 signaling pathway_Homo sapiens_hsa041150.69148009
100Prostate cancer_Homo sapiens_hsa052150.69025996
101Colorectal cancer_Homo sapiens_hsa052100.68779329
102Glioma_Homo sapiens_hsa052140.68647951
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.68512342
104Lysine degradation_Homo sapiens_hsa003100.67336402
105Tight junction_Homo sapiens_hsa045300.67321861
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66628078
107Renal cell carcinoma_Homo sapiens_hsa052110.65876573
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63997403
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62061440
110Estrogen signaling pathway_Homo sapiens_hsa049150.61734332
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61312645
112Dorso-ventral axis formation_Homo sapiens_hsa043200.60034596
113Fructose and mannose metabolism_Homo sapiens_hsa000510.60005837
114Carbon metabolism_Homo sapiens_hsa012000.59657132
115Sphingolipid metabolism_Homo sapiens_hsa006000.58936052
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58706248
117* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58010901
118Phagosome_Homo sapiens_hsa041450.57567531
119N-Glycan biosynthesis_Homo sapiens_hsa005100.56262557
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55732090
121Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55617683
122Galactose metabolism_Homo sapiens_hsa000520.54581809
123Rap1 signaling pathway_Homo sapiens_hsa040150.54140364
124ABC transporters_Homo sapiens_hsa020100.53638552
125Starch and sucrose metabolism_Homo sapiens_hsa005000.53236529
126Pathways in cancer_Homo sapiens_hsa052000.49576938
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46789079

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