CAND2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcoplasmic reticulum calcium ion transport (GO:0070296)9.38124465
2creatine metabolic process (GO:0006600)5.84582548
3response to muscle activity (GO:0014850)5.40382771
4skeletal muscle fiber development (GO:0048741)5.23917324
5muscle contraction (GO:0006936)5.11627668
6regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.11019636
7regulation of cell communication by electrical coupling (GO:0010649)5.06748308
8myotube cell development (GO:0014904)4.79203603
9muscle filament sliding (GO:0030049)4.66494956
10actin-myosin filament sliding (GO:0033275)4.66494956
11muscle system process (GO:0003012)4.61623658
12sarcomere organization (GO:0045214)4.58540212
13skeletal muscle adaptation (GO:0043501)4.57636772
14cardiac myofibril assembly (GO:0055003)4.53544703
15muscle fiber development (GO:0048747)4.45868882
16muscle hypertrophy (GO:0014896)4.43163961
17regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.42884611
18striated muscle adaptation (GO:0014888)4.34902954
19myofibril assembly (GO:0030239)4.34889582
20regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.33750250
21ribosomal small subunit assembly (GO:0000028)4.33588395
22regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.26651175
23glycogen catabolic process (GO:0005980)4.20210351
24viral transcription (GO:0019083)4.14753160
25regulation of striated muscle contraction (GO:0006942)4.13774359
26cardiac muscle hypertrophy in response to stress (GO:0014898)4.10234704
27muscle hypertrophy in response to stress (GO:0003299)4.10234704
28cardiac muscle adaptation (GO:0014887)4.10234704
29positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.06386177
30translational termination (GO:0006415)3.95394412
31NADH metabolic process (GO:0006734)3.90072245
32skeletal muscle tissue development (GO:0007519)3.89797823
33glucan catabolic process (GO:0009251)3.88928277
34glucan biosynthetic process (GO:0009250)3.87350487
35glycogen biosynthetic process (GO:0005978)3.87350487
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.86007608
37regulation of the force of heart contraction (GO:0002026)3.84392991
38actin-mediated cell contraction (GO:0070252)3.82248756
39striated muscle cell development (GO:0055002)3.81384447
40DNA deamination (GO:0045006)3.81328388
41negative regulation of myotube differentiation (GO:0010832)3.78951572
42muscle cell fate commitment (GO:0042693)3.71787484
43regulation of membrane repolarization (GO:0060306)3.69920022
44regulation of calcium ion transmembrane transport (GO:1903169)3.69280845
45regulation of calcium ion transmembrane transporter activity (GO:1901019)3.69280845
46telomere maintenance via semi-conservative replication (GO:0032201)3.68294510
47muscle cell cellular homeostasis (GO:0046716)3.67046656
48cardiac muscle cell development (GO:0055013)3.65772668
49cellular polysaccharide catabolic process (GO:0044247)3.58671185
50muscle organ development (GO:0007517)3.54528290
51muscle structure development (GO:0061061)3.54338949
52cardiac cell development (GO:0055006)3.50909884
53positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.49416800
54positive regulation of myotube differentiation (GO:0010831)3.47330344
55muscle adaptation (GO:0043500)3.45489992
56regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.45189338
57adult heart development (GO:0007512)3.44267676
58translational elongation (GO:0006414)3.40060567
59SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.38041516
60positive regulation of cation channel activity (GO:2001259)3.35529128
61regulation of relaxation of muscle (GO:1901077)3.33541316
62muscle cell development (GO:0055001)3.32545147
63skeletal muscle tissue regeneration (GO:0043403)3.29001680
64regulation of skeletal muscle contraction (GO:0014819)3.27799435
65ribosomal small subunit biogenesis (GO:0042274)3.27595431
66gluconeogenesis (GO:0006094)3.26187754
67DNA strand elongation involved in DNA replication (GO:0006271)3.25887587
68cotranslational protein targeting to membrane (GO:0006613)3.25780591
69protein targeting to ER (GO:0045047)3.25133786
70neuronal action potential propagation (GO:0019227)3.23499919
71carnitine shuttle (GO:0006853)3.22598406
72ribosomal large subunit biogenesis (GO:0042273)3.21942075
73polysaccharide catabolic process (GO:0000272)3.20372868
742-oxoglutarate metabolic process (GO:0006103)3.18657385
75response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.18595298
76telomere maintenance via recombination (GO:0000722)3.18513889
77negative regulation of calcium ion transmembrane transport (GO:1903170)3.18316772
78negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.18316772
79maturation of SSU-rRNA (GO:0030490)3.17975350
80heart contraction (GO:0060047)3.17757290
81heart process (GO:0003015)3.17757290
82regulation of skeletal muscle cell differentiation (GO:2001014)3.17533486
83myoblast fusion (GO:0007520)3.16825418
84DNA strand elongation (GO:0022616)3.14126909
85neuromuscular synaptic transmission (GO:0007274)3.13597632
86relaxation of muscle (GO:0090075)3.13597052
87tricarboxylic acid cycle (GO:0006099)3.13195970
88DNA replication initiation (GO:0006270)3.11933232
89nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.11853703
90establishment of protein localization to endoplasmic reticulum (GO:0072599)3.11518961
91glycogen metabolic process (GO:0005977)3.10546340
92regulation of muscle system process (GO:0090257)3.07224874
93striated muscle atrophy (GO:0014891)3.06928716
94regulation of ATPase activity (GO:0043462)3.04824731
95regulation of ATP catabolic process (GO:1903289)3.04824731
96paraxial mesoderm development (GO:0048339)3.03444293
97cellular glucan metabolic process (GO:0006073)3.02468083
98glucan metabolic process (GO:0044042)3.02468083
99regulation of sarcomere organization (GO:0060297)3.01469653
100translational initiation (GO:0006413)3.00269968
101cardiac muscle contraction (GO:0060048)2.99395747
102cardiac muscle tissue morphogenesis (GO:0055008)2.99312085
103protein localization to endoplasmic reticulum (GO:0070972)2.99126277
104negative regulation of striated muscle cell differentiation (GO:0051154)2.98238345
105regulation of myoblast differentiation (GO:0045661)2.96905693
106regulation of muscle contraction (GO:0006937)2.95924521
107viral life cycle (GO:0019058)2.94669238
108myotube differentiation (GO:0014902)2.94460231
109mitotic recombination (GO:0006312)2.91133647
110actomyosin structure organization (GO:0031032)2.89539677
111striated muscle tissue development (GO:0014706)2.88404510
112cellular protein complex disassembly (GO:0043624)2.88188065
113telomere maintenance via telomere lengthening (GO:0010833)2.87044760
114intra-S DNA damage checkpoint (GO:0031573)2.84514952
115ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.81854495
116regulation of actin filament-based movement (GO:1903115)2.81058181
117facial nerve structural organization (GO:0021612)2.76561677
118striated muscle contraction (GO:0006941)2.75246837
119muscle tissue morphogenesis (GO:0060415)2.71082846
120protein complex disassembly (GO:0043241)2.69820865
121skeletal muscle contraction (GO:0003009)2.69241714
122DNA damage response, detection of DNA damage (GO:0042769)2.67082162
123negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.67027970
124kinetochore assembly (GO:0051382)2.64691534
125negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.63832934
126mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.63539527
127cardiac chamber formation (GO:0003207)2.60555886
128response to inactivity (GO:0014854)2.60217388
129regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.59891093
130urogenital system development (GO:0001655)2.56786161
131kinetochore organization (GO:0051383)2.56605909
132actin filament-based movement (GO:0030048)2.56088686
133macromolecular complex disassembly (GO:0032984)2.55299418
134regulation of stem cell maintenance (GO:2000036)2.54298192
135negative regulation of RNA splicing (GO:0033119)2.51918240
136plasma membrane repair (GO:0001778)2.48576814
137deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.48497143
138nuclear-transcribed mRNA catabolic process (GO:0000956)2.47188427
139pattern specification involved in kidney development (GO:0061004)2.46959175
140cell migration involved in heart development (GO:0060973)2.46661670
141nucleotide-excision repair, DNA gap filling (GO:0006297)2.42577485
1423-UTR-mediated mRNA stabilization (GO:0070935)2.42575078
143cardiac muscle hypertrophy (GO:0003300)2.40741960
144mRNA catabolic process (GO:0006402)2.40430566
145DNA replication checkpoint (GO:0000076)2.39319596
146cranial nerve morphogenesis (GO:0021602)2.39314576
147ubiquinone biosynthetic process (GO:0006744)2.38181164
148quinone biosynthetic process (GO:1901663)2.38181164
149translation (GO:0006412)2.36085151
150mesonephros development (GO:0001823)2.35810901
151negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.35325520
152atrial septum morphogenesis (GO:0060413)2.35303278
153RNA catabolic process (GO:0006401)2.35168503
154IMP biosynthetic process (GO:0006188)2.34904923
155regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.33868940
156cardiac ventricle formation (GO:0003211)2.32544470
157negative regulation of mRNA processing (GO:0050686)2.32224315
158regulation of nuclear cell cycle DNA replication (GO:0033262)2.32220753
159positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.30434450
160IMP metabolic process (GO:0046040)2.30019825
161ribonucleoprotein complex biogenesis (GO:0022613)2.29695300
162negative regulation of potassium ion transmembrane transport (GO:1901380)2.27758645
163lymphoid progenitor cell differentiation (GO:0002320)2.27226980
164DNA unwinding involved in DNA replication (GO:0006268)2.26859425
165CENP-A containing nucleosome assembly (GO:0034080)2.26235030
166striated muscle hypertrophy (GO:0014897)2.26204361
167DNA ligation (GO:0006266)2.25882260
168tRNA methylation (GO:0030488)2.25634218

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.44211271
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.19342758
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.16193144
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.43167329
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.15981599
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.13061142
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.01843479
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.01578626
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.94356393
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.88559254
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.79989298
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.79383753
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.71644327
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.63669542
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.63162731
16ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.61155126
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.60116804
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.54696720
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.54302442
20TBX20_22328084_ChIP-Seq_HEART_Mouse2.44681745
21TBX20_22080862_ChIP-Seq_HEART_Mouse2.44681745
22CIITA_25753668_ChIP-Seq_RAJI_Human2.44618200
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.42758840
24EP300_21415370_ChIP-Seq_HL-1_Mouse2.40592777
25ETS1_20019798_ChIP-Seq_JURKAT_Human2.39321395
26GABP_17652178_ChIP-ChIP_JURKAT_Human2.27918051
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.26424684
28GBX2_23144817_ChIP-Seq_PC3_Human2.17852852
29NOTCH1_21737748_ChIP-Seq_TLL_Human2.10182472
30CDX2_19796622_ChIP-Seq_MESCs_Mouse2.09632308
31XRN2_22483619_ChIP-Seq_HELA_Human2.06490778
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01087401
33DROSHA_22980978_ChIP-Seq_HELA_Human2.00843604
34TTF2_22483619_ChIP-Seq_HELA_Human1.99392890
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95799167
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.95368036
37CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.93807658
38RARB_27405468_Chip-Seq_BRAIN_Mouse1.93648168
39FOXP3_21729870_ChIP-Seq_TREG_Human1.93317538
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92228656
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91516813
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.91332005
43VDR_23849224_ChIP-Seq_CD4+_Human1.87383294
44* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.87303988
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.84119689
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.82858842
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.82338093
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81115414
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.80989510
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.79785807
51CTCF_27219007_Chip-Seq_Bcells_Human1.78411312
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.76872704
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.76799111
54BP1_19119308_ChIP-ChIP_Hs578T_Human1.76695471
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.76146084
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.73065094
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.72274747
58* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.70367178
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69954100
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.68611287
61* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.68465213
62* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.68306166
63MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.66184884
64SCL_19346495_ChIP-Seq_HPC-7_Human1.63609676
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62042180
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.59952287
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.59913161
68DCP1A_22483619_ChIP-Seq_HELA_Human1.59909578
69RNF2_18974828_ChIP-Seq_MESCs_Mouse1.58838723
70EZH2_18974828_ChIP-Seq_MESCs_Mouse1.58838723
71JARID2_20075857_ChIP-Seq_MESCs_Mouse1.58391602
72CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.55082017
73TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54439862
74PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54322310
75MYC_22102868_ChIP-Seq_BL_Human1.54256304
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53794955
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52917281
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.52662637
79GATA4_21415370_ChIP-Seq_HL-1_Mouse1.52119389
80ESR1_20079471_ChIP-ChIP_T-47D_Human1.50765114
81SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.47325781
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46861047
83AR_21572438_ChIP-Seq_LNCaP_Human1.45103572
84VDR_21846776_ChIP-Seq_THP-1_Human1.44271605
85NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.42899133
86MTF2_20144788_ChIP-Seq_MESCs_Mouse1.41766776
87THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41662226
88NANOG_18555785_ChIP-Seq_MESCs_Mouse1.39487883
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.38922781
90SOX2_18555785_ChIP-Seq_MESCs_Mouse1.38138435
91JARID2_20064375_ChIP-Seq_MESCs_Mouse1.36437435
92POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35771793
93GABP_19822575_ChIP-Seq_HepG2_Human1.35441138
94ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31713097
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.31684437
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.31351417
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.30664872
98MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30368317
99NFIB_24661679_ChIP-Seq_LUNG_Mouse1.30010178
100SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29736049
101ELK1_19687146_ChIP-ChIP_HELA_Human1.29587090
102MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27034702
103SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26411031
104SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.25227194
105SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.24937833
106RNF2_27304074_Chip-Seq_ESCs_Mouse1.23912450
107SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.23406805
108RBPJ_22232070_ChIP-Seq_NCS_Mouse1.23386574
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.22685392
110TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17682014
111CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14588621
112MYC_18940864_ChIP-ChIP_HL60_Human1.14445362
113* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13150279
114SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13145155
115POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12480153
116LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12404138
117RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11923086
118SOX2_21211035_ChIP-Seq_LN229_Gbm1.10636968
119IGF1R_20145208_ChIP-Seq_DFB_Human1.10558556
120EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10095899
121POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08111910
122KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.06396384
123GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05813653
124EZH2_22144423_ChIP-Seq_EOC_Human1.05018413
125MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04625722
126SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04021083
127ISL1_27105846_Chip-Seq_CPCs_Mouse1.03934921
128ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03878793
129OCT4_20526341_ChIP-Seq_ESCs_Human1.02857678
130RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02583533
131TP53_20018659_ChIP-ChIP_R1E_Mouse1.01997546
132NANOG_16153702_ChIP-ChIP_HESCs_Human1.01741195
133ERG_21242973_ChIP-ChIP_JURKAT_Human1.00395827
134ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98653870
135* SPI1_23547873_ChIP-Seq_NB4_Human0.98531787
136DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98076189
137EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97761860
138AR_19668381_ChIP-Seq_PC3_Human0.97603636
139MAF_26560356_Chip-Seq_TH1_Human0.97487875
140* REST_18959480_ChIP-ChIP_MESCs_Mouse0.96593164
141SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95133630
142EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94791081
143EGR1_19374776_ChIP-ChIP_THP-1_Human0.93912642
144EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.93910568
145PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93701591
146EED_16625203_ChIP-ChIP_MESCs_Mouse0.91943943
147SOX9_26525672_Chip-Seq_HEART_Mouse0.91659224
148NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.91309857
149MYC_27129775_Chip-Seq_CORNEA_Mouse0.90747432
150DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90394409
151ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90248279
152YY1_22570637_ChIP-Seq_MALME-3M_Human0.89868873
153HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.89654974
154TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89343843
155NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89305876
156CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.89192444
157TP53_23651856_ChIP-Seq_MEFs_Mouse0.89172606
158RUNX1_26923725_Chip-Seq_HPCs_Mouse0.89106327
159CBP_20019798_ChIP-Seq_JUKART_Human0.88195176
160IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88195176
161SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87320270
162DPY_21335234_ChIP-Seq_ESCs_Mouse0.85704746
163TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.84425630
164SMC3_22415368_ChIP-Seq_MEFs_Mouse0.84356866
165WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84009946
166SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.83712141
167SMAD4_21799915_ChIP-Seq_A2780_Human0.83304541
168CTCF_21964334_ChIP-Seq_BJAB-B_Human0.83049914
169VDR_24763502_ChIP-Seq_THP-1_Human0.83001664
170SOX2_16153702_ChIP-ChIP_HESCs_Human0.82965514
171UTX_26944678_Chip-Seq_JUKART_Human0.82812728
172TBL1_22424771_ChIP-Seq_293T_Human0.82746357
173REST_21632747_ChIP-Seq_MESCs_Mouse0.82591778
174MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.81684508
175NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.81354995
176LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81006583
177PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.80448194
178CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.79736249
179P53_22127205_ChIP-Seq_FIBROBLAST_Human0.79348708
180RING1B_27294783_Chip-Seq_NPCs_Mouse0.78167954
181E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.77932601
182ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.77757910
183RING1B_27294783_Chip-Seq_ESCs_Mouse0.77651915
184TET1_21490601_ChIP-Seq_MESCs_Mouse0.77161082
185NFYB_21822215_ChIP-Seq_K562_Human0.77145314
186SA1_27219007_Chip-Seq_Bcells_Human0.76928160
187PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.76294613
188STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.76121830

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.33898556
2MP0000751_myopathy3.29204877
3MP0004084_abnormal_cardiac_muscle3.22047765
4MP0002837_dystrophic_cardiac_calcinosis3.08990204
5MP0000749_muscle_degeneration2.97056621
6MP0004130_abnormal_muscle_cell2.63546479
7MP0006292_abnormal_olfactory_placode2.54303075
8MP0004215_abnormal_myocardial_fiber2.52687636
9MP0002332_abnormal_exercise_endurance2.42162250
10MP0009379_abnormal_foot_pigmentation2.41525732
11MP0005451_abnormal_body_composition2.39995144
12MP0004145_abnormal_muscle_electrophysio2.37612594
13MP0003567_abnormal_fetal_cardiomyocyte2.29029825
14MP0004036_abnormal_muscle_relaxation2.14864514
15MP0005330_cardiomyopathy2.13638572
16MP0003828_pulmonary_edema2.10067868
17MP0000750_abnormal_muscle_regeneration2.09755905
18MP0010030_abnormal_orbit_morphology2.08897693
19MP0000049_abnormal_middle_ear1.99399529
20MP0002106_abnormal_muscle_physiology1.99249083
21MP0004270_analgesia1.98966484
22MP0003137_abnormal_impulse_conducting1.84113893
23MP0004087_abnormal_muscle_fiber1.83096135
24MP0002108_abnormal_muscle_morphology1.79733287
25MP0010630_abnormal_cardiac_muscle1.78090837
26MP0010094_abnormal_chromosome_stability1.73008179
27MP0000013_abnormal_adipose_tissue1.69581316
28MP0003941_abnormal_skin_development1.68204605
29MP0005369_muscle_phenotype1.62812881
30MP0004510_myositis1.62234430
31MP0008058_abnormal_DNA_repair1.61493633
32MP0000566_synostosis1.59261091
33MP0002249_abnormal_larynx_morphology1.59026643
34MP0002972_abnormal_cardiac_muscle1.57597240
35MP0008007_abnormal_cellular_replicative1.57007798
36MP0006036_abnormal_mitochondrial_physio1.56772298
37MP0000759_abnormal_skeletal_muscle1.55573988
38MP0003693_abnormal_embryo_hatching1.55532823
39MP0001544_abnormal_cardiovascular_syste1.47343207
40MP0005385_cardiovascular_system_phenoty1.47343207
41MP0005620_abnormal_muscle_contractility1.46455028
42MP0005174_abnormal_tail_pigmentation1.46179238
43MP0002396_abnormal_hematopoietic_system1.46042980
44MP0005409_darkened_coat_color1.45910650
45MP0003385_abnormal_body_wall1.45736770
46MP0001188_hyperpigmentation1.44363541
47MP0003077_abnormal_cell_cycle1.42866440
48MP0002234_abnormal_pharynx_morphology1.36737730
49MP0003111_abnormal_nucleus_morphology1.32370467
50MP0008775_abnormal_heart_ventricle1.31872262
51MP0002127_abnormal_cardiovascular_syste1.30662400
52MP0000678_abnormal_parathyroid_gland1.30213223
53MP0003122_maternal_imprinting1.28918102
54MP0006138_congestive_heart_failure1.28478379
55MP0003136_yellow_coat_color1.27979905
56MP0002938_white_spotting1.24008941
57MP0010368_abnormal_lymphatic_system1.20468082
58MP0002269_muscular_atrophy1.19995668
59MP0008932_abnormal_embryonic_tissue1.19580987
60MP0004484_altered_response_of1.18668247
61MP0003123_paternal_imprinting1.16961066
62MP0009250_abnormal_appendicular_skeleto1.16144420
63MP0004808_abnormal_hematopoietic_stem1.15273638
64MP0004957_abnormal_blastocyst_morpholog1.14181491
65MP0005266_abnormal_metabolism1.13227300
66MP0002177_abnormal_outer_ear1.11842021
67MP0000733_abnormal_muscle_development1.07943878
68MP0002095_abnormal_skin_pigmentation1.06222496
69MP0005423_abnormal_somatic_nervous1.05160276
70MP0003221_abnormal_cardiomyocyte_apopto1.04626817
71MP0004233_abnormal_muscle_weight1.04258647
72MP0000015_abnormal_ear_pigmentation1.04147520
73MP0003937_abnormal_limbs/digits/tail_de1.03747689
74MP0000266_abnormal_heart_morphology1.02209660
75MP0001661_extended_life_span1.01765790
76MP0000003_abnormal_adipose_tissue1.01481587
77MP0004859_abnormal_synaptic_plasticity1.01171648
78MP0002822_catalepsy1.00910594
79MP0003315_abnormal_perineum_morphology1.00637694
80MP0003935_abnormal_craniofacial_develop0.99396983
81MP0001293_anophthalmia0.98959164
82MP0000428_abnormal_craniofacial_morphol0.98739920
83MP0001299_abnormal_eye_distance/0.96744035
84MP0003121_genomic_imprinting0.96737911
85MP0001879_abnormal_lymphatic_vessel0.95664661
86MP0005670_abnormal_white_adipose0.95001881
87MP0000747_muscle_weakness0.93632881
88MP0000490_abnormal_crypts_of0.92870790
89MP0003763_abnormal_thymus_physiology0.88818395
90MP0002751_abnormal_autonomic_nervous0.88237822
91MP0008057_abnormal_DNA_replication0.88158146
92MP0002971_abnormal_brown_adipose0.85089796
93MP0002932_abnormal_joint_morphology0.84514530
94MP0005375_adipose_tissue_phenotype0.84427609
95MP0004085_abnormal_heartbeat0.82107918
96MP0003984_embryonic_growth_retardation0.81680093
97MP0002088_abnormal_embryonic_growth/wei0.80449733
98MP0001672_abnormal_embryogenesis/_devel0.80364267
99MP0005380_embryogenesis_phenotype0.80364267
100MP0003279_aneurysm0.79960716
101MP0004381_abnormal_hair_follicle0.79811107
102MP0000372_irregular_coat_pigmentation0.78799062
103MP0005075_abnormal_melanosome_morpholog0.78730120
104MP0002734_abnormal_mechanical_nocicepti0.78323695
105MP0000762_abnormal_tongue_morphology0.78178718
106MP0002085_abnormal_embryonic_tissue0.77472943
107MP0009053_abnormal_anal_canal0.77276804
108MP0005666_abnormal_adipose_tissue0.74946995
109MP0003938_abnormal_ear_development0.73930111
110MP0008569_lethality_at_weaning0.73089471
111MP0002116_abnormal_craniofacial_bone0.72080372
112MP0000767_abnormal_smooth_muscle0.71115021
113MP0004133_heterotaxia0.71070412
114MP0003942_abnormal_urinary_system0.70135545
115MP0002075_abnormal_coat/hair_pigmentati0.69566398
116MP0002925_abnormal_cardiovascular_devel0.67901897
117MP0002102_abnormal_ear_morphology0.67515799
118MP0003786_premature_aging0.67484000
119MP0002128_abnormal_blood_circulation0.67414361
120MP0003755_abnormal_palate_morphology0.66824608
121MP0004197_abnormal_fetal_growth/weight/0.66695413
122MP0003879_abnormal_hair_cell0.65662255
123MP0004185_abnormal_adipocyte_glucose0.65590760
124MP0009780_abnormal_chondrocyte_physiolo0.63885223
125MP0002638_abnormal_pupillary_reflex0.61875478
126MP0006276_abnormal_autonomic_nervous0.61469397
127MP0005187_abnormal_penis_morphology0.60994740
128MP0003635_abnormal_synaptic_transmissio0.57107925
129MP0003950_abnormal_plasma_membrane0.56297320
130MP0002114_abnormal_axial_skeleton0.50279177
131MP0001984_abnormal_olfaction0.50029757
132MP0009672_abnormal_birth_weight0.48082990
133MP0002272_abnormal_nervous_system0.47162190
134MP0001486_abnormal_startle_reflex0.46502529
135MP0002066_abnormal_motor_capabilities/c0.46452049
136MP0001529_abnormal_vocalization0.46202977
137MP0004147_increased_porphyrin_level0.46043387
138MP0004134_abnormal_chest_morphology0.45910422
139MP0004043_abnormal_pH_regulation0.45523048
140MP0001346_abnormal_lacrimal_gland0.45385550
141MP0002067_abnormal_sensory_capabilities0.42643734
142MP0002063_abnormal_learning/memory/cond0.41864763
143MP0003045_fibrosis0.41831674
144MP0004924_abnormal_behavior0.40814714
145MP0005386_behavior/neurological_phenoty0.40814714
146MP0002064_seizures0.39533158
147MP0002078_abnormal_glucose_homeostasis0.38433438
148MP0009745_abnormal_behavioral_response0.37272367
149MP0001502_abnormal_circadian_rhythm0.37080488
150MP0001943_abnormal_respiration0.36196326
151MP0003948_abnormal_gas_homeostasis0.35274312
152MP0006035_abnormal_mitochondrial_morpho0.33777780
153MP0004142_abnormal_muscle_tone0.33645853
154MP0005645_abnormal_hypothalamus_physiol0.32510211
155MP0005452_abnormal_adipose_tissue0.30544081
156MP0005623_abnormal_meninges_morphology0.28072968

Predicted human phenotypes

RankGene SetZ-score
1Myopathic facies (HP:0002058)5.40622049
2Subaortic stenosis (HP:0001682)5.00737557
3Abnormality of the left ventricular outflow tract (HP:0011103)5.00737557
4Centrally nucleated skeletal muscle fibers (HP:0003687)4.52600015
5Round ear (HP:0100830)4.49550965
6Sudden death (HP:0001699)4.49242024
7Calf muscle hypertrophy (HP:0008981)4.43410095
8Ulnar deviation of the wrist (HP:0003049)4.20674163
9Ventricular tachycardia (HP:0004756)4.17504439
10Muscle hypertrophy of the lower extremities (HP:0008968)4.16374546
11Difficulty running (HP:0009046)3.91861899
12Abnormality of the calf musculature (HP:0001430)3.66485512
13Lipoatrophy (HP:0100578)3.65111731
14Atrial fibrillation (HP:0005110)3.61976481
15Increased variability in muscle fiber diameter (HP:0003557)3.52422526
16Supraventricular tachycardia (HP:0004755)3.41437007
17Primary atrial arrhythmia (HP:0001692)3.38434832
18Exercise-induced muscle cramps (HP:0003710)3.37780483
19Muscle stiffness (HP:0003552)3.36836908
20Supraventricular arrhythmia (HP:0005115)3.32453824
21Absent phalangeal crease (HP:0006109)3.32248470
22Exercise-induced myalgia (HP:0003738)3.25835297
23Frequent falls (HP:0002359)3.25278942
24Muscle fiber inclusion bodies (HP:0100299)3.23144933
25Reticulocytopenia (HP:0001896)3.22106919
26EMG: neuropathic changes (HP:0003445)3.21697682
27Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.20568485
28Muscle fiber splitting (HP:0003555)3.08911915
29Malignant hyperthermia (HP:0002047)3.05441747
30Type I transferrin isoform profile (HP:0003642)2.90979323
31Type 1 muscle fiber predominance (HP:0003803)2.88049642
32Dilated cardiomyopathy (HP:0001644)2.87823141
33Generalized muscle weakness (HP:0003324)2.79869495
34Fetal akinesia sequence (HP:0001989)2.77589269
35Nemaline bodies (HP:0003798)2.76355490
36EMG: myopathic abnormalities (HP:0003458)2.74068128
37Abnormal finger flexion creases (HP:0006143)2.69206613
38Type 2 muscle fiber atrophy (HP:0003554)2.50785310
39Muscle fiber atrophy (HP:0100295)2.49483414
40Reduced antithrombin III activity (HP:0001976)2.46811906
41Distal lower limb amyotrophy (HP:0008944)2.43127303
42Hepatocellular necrosis (HP:0001404)2.42487145
43Aplastic anemia (HP:0001915)2.41813002
44Hepatic necrosis (HP:0002605)2.40543062
45Scapular winging (HP:0003691)2.39218936
46Bulbar palsy (HP:0001283)2.36500679
47Abnormality of the calcaneus (HP:0008364)2.35788546
48Abnormality of cells of the erythroid lineage (HP:0012130)2.35015381
49Prolonged QT interval (HP:0001657)2.33311413
50Abnormal number of erythroid precursors (HP:0012131)2.32085208
51Chromosomal breakage induced by crosslinking agents (HP:0003221)2.29212796
52Slender build (HP:0001533)2.26206065
53Myoglobinuria (HP:0002913)2.24710698
54Gowers sign (HP:0003391)2.24709291
55Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.23014565
56Hyperkalemia (HP:0002153)2.20798643
57Increased connective tissue (HP:0009025)2.18600515
58Abnormality of the foot musculature (HP:0001436)2.17537050
59Lower limb amyotrophy (HP:0007210)2.17491943
60Spinal rigidity (HP:0003306)2.15159257
61Difficulty climbing stairs (HP:0003551)2.14316923
62Muscular dystrophy (HP:0003560)2.14156001
63Fatigable weakness (HP:0003473)2.10539883
64Abnormality of the neuromuscular junction (HP:0003398)2.10539883
65Long clavicles (HP:0000890)2.09741957
66Weak cry (HP:0001612)2.08657608
67Chromsome breakage (HP:0040012)2.08132641
68Progressive muscle weakness (HP:0003323)2.05329583
69Proximal amyotrophy (HP:0007126)2.05113479
70Abnormality of the shoulder girdle musculature (HP:0001435)2.04543612
71Rhabdomyolysis (HP:0003201)2.04443179
72Waddling gait (HP:0002515)1.98935665
73Aplasia/Hypoplasia of the sacrum (HP:0008517)1.98580083
74Increased hepatocellular lipid droplets (HP:0006565)1.98124539
75Palpitations (HP:0001962)1.97873744
76Foot dorsiflexor weakness (HP:0009027)1.96050733
77Testicular atrophy (HP:0000029)1.93751674
78Distal arthrogryposis (HP:0005684)1.92747407
79Syncope (HP:0001279)1.91318891
80Nonprogressive disorder (HP:0003680)1.90279281
81Mitochondrial inheritance (HP:0001427)1.90156091
82Exercise intolerance (HP:0003546)1.90058683
83Meckel diverticulum (HP:0002245)1.88621348
84Calcaneovalgus deformity (HP:0001848)1.88124699
85Bundle branch block (HP:0011710)1.85132173
86Increased intramyocellular lipid droplets (HP:0012240)1.84463485
87Pulmonary artery stenosis (HP:0004415)1.84066385
88Abnormal number of incisors (HP:0011064)1.82290779
89Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.81064915
90Short 4th metacarpal (HP:0010044)1.81064915
91Pallor (HP:0000980)1.80601070
92Respiratory insufficiency due to muscle weakness (HP:0002747)1.79593863
93Decreased activity of mitochondrial respiratory chain (HP:0008972)1.79355161
94Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.79355161
95Lipid accumulation in hepatocytes (HP:0006561)1.78756478
96Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.78273668
97Ventricular arrhythmia (HP:0004308)1.78175292
98Neck muscle weakness (HP:0000467)1.78134663
99Supernumerary spleens (HP:0009799)1.77525614
100Limb-girdle muscle weakness (HP:0003325)1.76585575
101Abnormality of the ileum (HP:0001549)1.76183399
102Myotonia (HP:0002486)1.74890167
103Short middle phalanx of the 5th finger (HP:0004220)1.74773241
104Heart block (HP:0012722)1.74420638
105Selective tooth agenesis (HP:0001592)1.74251103
106Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.73363917
107Abnormal protein N-linked glycosylation (HP:0012347)1.73363917
108Abnormal protein glycosylation (HP:0012346)1.73363917
109Abnormal glycosylation (HP:0012345)1.73363917
110Shoulder girdle muscle weakness (HP:0003547)1.72807754
111Asymmetric septal hypertrophy (HP:0001670)1.72683327
112Mildly elevated creatine phosphokinase (HP:0008180)1.72664996
113Aplasia/Hypoplasia of the uvula (HP:0010293)1.72018555
114Abnormality of the hip-girdle musculature (HP:0001445)1.71663704
115Abnormality of the musculature of the pelvis (HP:0001469)1.71663704
116Abnormality of the phalanges of the hallux (HP:0010057)1.71088837
117Acute necrotizing encephalopathy (HP:0006965)1.70907408
118Popliteal pterygium (HP:0009756)1.70083990
119Nephroblastoma (Wilms tumor) (HP:0002667)1.69548870
120Areflexia of lower limbs (HP:0002522)1.69340067
121Maternal diabetes (HP:0009800)1.69172908
122Hip contracture (HP:0003273)1.68828101
123Atrioventricular block (HP:0001678)1.68266184
124Deformed tarsal bones (HP:0008119)1.68092271
125Increased CSF lactate (HP:0002490)1.67403769
126Limb-girdle muscle atrophy (HP:0003797)1.67250040
127Hyporeflexia of lower limbs (HP:0002600)1.67207872
128Abnormal atrioventricular conduction (HP:0005150)1.66921200
129Ragged-red muscle fibers (HP:0003200)1.66438440
130Hypoplastic heart (HP:0001961)1.66242172
131Metatarsus adductus (HP:0001840)1.66122972
132Increased muscle lipid content (HP:0009058)1.66110844
133Abnormality of the preputium (HP:0100587)1.65976073
134Abnormality of skeletal muscle fiber size (HP:0012084)1.65074139
135Abnormal mitochondria in muscle tissue (HP:0008316)1.65050243
136Limited hip movement (HP:0008800)1.65006618
137Right ventricular cardiomyopathy (HP:0011663)1.64062467
138Rimmed vacuoles (HP:0003805)1.63619331
139Congenital, generalized hypertrichosis (HP:0004540)1.63063291
140Triphalangeal thumb (HP:0001199)1.62833263
141Distal lower limb muscle weakness (HP:0009053)1.62606985
142Abnormal EKG (HP:0003115)1.62447111
143Pelvic girdle muscle weakness (HP:0003749)1.61077897
144Steppage gait (HP:0003376)1.56667365
145Left ventricular hypertrophy (HP:0001712)1.53618438
146Ulnar deviation of finger (HP:0009465)1.48518490
147Ventricular fibrillation (HP:0001663)1.42779262
148Facial diplegia (HP:0001349)1.41802103

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK3.94927224
2MUSK3.51592801
3MKNK23.25887582
4OBSCN3.24270504
5TLK12.86853985
6NLK2.71469527
7TTN2.70617631
8NME22.63930707
9MKNK12.63738747
10WEE12.21299549
11EIF2AK32.21062910
12STK162.14735329
13SRPK12.12964876
14MARK12.03534875
15FLT31.91078234
16MAPK121.86010413
17PHKG11.84392774
18PHKG21.84392774
19ZAK1.80911965
20TIE11.80550819
21MYLK1.78885212
22DYRK31.60065901
23TGFBR11.58743969
24EEF2K1.50393926
25BUB11.48021068
26PKN21.44472873
27CDC71.35714894
28MAP3K101.30658191
29EIF2AK21.29596602
30DMPK1.24659359
31MAP2K41.22259040
32MAP2K31.17685564
33VRK11.13355337
34CDK71.13267203
35TEC1.10299208
36CLK11.09136717
37STK41.03024643
38EPHB21.02410407
39EIF2AK11.01902208
40CDK41.01430724
41BRSK20.99166822
42BRD40.98652787
43PRKD20.98594757
44NEK90.98587945
45KIT0.95902517
46BTK0.95843323
47CDK80.94956777
48STK240.94700311
49CAMK2G0.93323494
50NME10.93106812
51ACVR1B0.92870738
52PRKAA10.89152851
53BCKDK0.88858805
54TRPM70.88425155
55MAPKAPK30.88159205
56RPS6KA40.86389536
57ILK0.85869039
58IRAK40.84124853
59ATR0.83907258
60AURKB0.81975620
61PASK0.81055200
62PIK3CA0.80683196
63IRAK10.79670581
64YES10.78969095
65IRAK30.78454773
66KDR0.77791771
67PRKAA20.76256723
68LIMK10.75636956
69NEK20.75236017
70DYRK1B0.73564471
71PKN10.73535841
72PLK40.73435778
73ICK0.72578470
74CAMK2D0.71131805
75TGFBR20.71069634
76LMTK20.71018544
77CDK190.69588909
78KSR20.69264968
79CAMK2A0.69201116
80MOS0.69164164
81PIK3CG0.68848316
82CAMK10.68033556
83MAP3K70.66675596
84PLK10.66070446
85CASK0.65358096
86CAMK40.64570998
87RPS6KB20.62442231
88ZAP700.61633683
89AKT20.60099031
90EPHA40.59659673
91RPS6KC10.59478144
92RPS6KL10.59478144
93PRKG10.59381400
94TTK0.59274879
95CAMK2B0.58752655
96SGK30.57909092
97PINK10.56411220
98RIPK10.55770093
99STK38L0.54273969
100NTRK30.52408043
101PIM20.52290927
102MAPK70.51987338
103MAP2K60.51830857
104PDK20.50903245
105RPS6KA60.49798576
106LATS20.48787643
107PAK60.47975713
108TXK0.47122051
109SGK20.46988149
110NEK10.45262369
111MAPK110.43675033
112STK380.43551541
113ERBB30.43121478
114MAPK100.42286038
115HIPK20.42185156
116SGK4940.41562446
117SGK2230.41562446
118MAPK40.41454838
119CDC42BPA0.40818575
120MAP2K10.40352391
121PRKACA0.38717223
122IRAK20.38152565
123GRK70.38087803
124RPS6KA30.37746741
125CHEK20.37316071
126MAP3K130.36945160
127MARK20.36816892
128CCNB10.36770249
129CSNK2A10.36764095
130PAK40.36665426
131MAP4K20.36259875
132RPS6KA10.35427975
133UHMK10.35339114
134RPS6KA50.35245324
135MAP3K90.34915466
136MAPK130.33341622
137ATM0.32786060
138PDK40.32038146
139PDK30.32038146
140SGK10.31962032
141PRKG20.31666669
142MTOR0.31658706
143DAPK20.31618177
144PIM10.31579208
145PRKACB0.31299835
146LATS10.31216340
147EPHA30.30924706
148TRIB30.30589371
149CDK120.30484474
150ROCK10.29645473
151NTRK20.28974304
152PRKD10.28299155
153CDK50.27674709
154STK110.25594139
155RPS6KB10.25119979
156MAP3K40.23660198
157PDPK10.23543256
158CAMK1G0.22407105
159GSK3B0.22366469
160PRKD30.21360448
161ARAF0.21052594
162WNK10.20681679
163PRKDC0.18833358
164RAF10.18376872
165PNCK0.17876931
166BRAF0.17825281
167RPS6KA20.17262894
168PRKACG0.17090794

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.14752699
2Ribosome_Homo sapiens_hsa030104.06409873
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.58017828
4Mismatch repair_Homo sapiens_hsa034303.15996097
5Homologous recombination_Homo sapiens_hsa034402.83449612
6Base excision repair_Homo sapiens_hsa034102.74984988
7Spliceosome_Homo sapiens_hsa030402.70015742
8RNA polymerase_Homo sapiens_hsa030202.25411079
9Fanconi anemia pathway_Homo sapiens_hsa034602.21274487
10Nucleotide excision repair_Homo sapiens_hsa034202.13097244
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.01912008
12Cardiac muscle contraction_Homo sapiens_hsa042601.95970166
13Glucagon signaling pathway_Homo sapiens_hsa049221.94918748
14Pyrimidine metabolism_Homo sapiens_hsa002401.94274428
15Calcium signaling pathway_Homo sapiens_hsa040201.82150526
16Oxytocin signaling pathway_Homo sapiens_hsa049211.80236382
17Dilated cardiomyopathy_Homo sapiens_hsa054141.80171723
18Cell cycle_Homo sapiens_hsa041101.75677696
19Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75616631
20Basal cell carcinoma_Homo sapiens_hsa052171.73165393
21Arginine and proline metabolism_Homo sapiens_hsa003301.73125612
22RNA degradation_Homo sapiens_hsa030181.68719372
23RNA transport_Homo sapiens_hsa030131.64289426
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.64269039
25Parkinsons disease_Homo sapiens_hsa050121.61481625
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.60492533
27Arginine biosynthesis_Homo sapiens_hsa002201.58591448
28cGMP-PKG signaling pathway_Homo sapiens_hsa040221.57139274
29Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.50450864
30Viral myocarditis_Homo sapiens_hsa054161.42984150
31Pyruvate metabolism_Homo sapiens_hsa006201.41905493
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41504679
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.40325245
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.38775346
35Basal transcription factors_Homo sapiens_hsa030221.36384767
36Proteasome_Homo sapiens_hsa030501.35644988
37Pentose phosphate pathway_Homo sapiens_hsa000301.34076845
38Oxidative phosphorylation_Homo sapiens_hsa001901.33197048
39Non-homologous end-joining_Homo sapiens_hsa034501.30016597
40Huntingtons disease_Homo sapiens_hsa050161.28553851
41Biosynthesis of amino acids_Homo sapiens_hsa012301.27415500
42Thyroid cancer_Homo sapiens_hsa052161.26737443
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.26260139
44AMPK signaling pathway_Homo sapiens_hsa041521.25346148
45Propanoate metabolism_Homo sapiens_hsa006401.25080751
46Protein export_Homo sapiens_hsa030601.23975785
47Fructose and mannose metabolism_Homo sapiens_hsa000511.23408118
48Purine metabolism_Homo sapiens_hsa002301.23368096
49Gastric acid secretion_Homo sapiens_hsa049711.21534136
50Insulin secretion_Homo sapiens_hsa049111.20880000
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.18579679
52Herpes simplex infection_Homo sapiens_hsa051681.17725672
53One carbon pool by folate_Homo sapiens_hsa006701.13252714
54Transcriptional misregulation in cancer_Homo sapiens_hsa052021.12729950
55Insulin resistance_Homo sapiens_hsa049311.12311466
56p53 signaling pathway_Homo sapiens_hsa041151.12169238
57Circadian entrainment_Homo sapiens_hsa047131.11521475
58mRNA surveillance pathway_Homo sapiens_hsa030151.10443478
59Long-term potentiation_Homo sapiens_hsa047201.06788619
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05071183
61Notch signaling pathway_Homo sapiens_hsa043301.04860847
62Vascular smooth muscle contraction_Homo sapiens_hsa042701.04276269
63Renin secretion_Homo sapiens_hsa049241.03079351
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01241528
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00060115
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.93848876
67Hedgehog signaling pathway_Homo sapiens_hsa043400.92461253
68Alzheimers disease_Homo sapiens_hsa050100.91637976
69Primary immunodeficiency_Homo sapiens_hsa053400.90817865
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90672268
71Fatty acid degradation_Homo sapiens_hsa000710.89368982
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88025120
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87797954
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87494258
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.86017414
76HTLV-I infection_Homo sapiens_hsa051660.84995198
77Systemic lupus erythematosus_Homo sapiens_hsa053220.82955351
78Wnt signaling pathway_Homo sapiens_hsa043100.80905273
79Fatty acid metabolism_Homo sapiens_hsa012120.80053082
80Amphetamine addiction_Homo sapiens_hsa050310.79231083
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79001238
82Cholinergic synapse_Homo sapiens_hsa047250.77067093
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76229219
84GnRH signaling pathway_Homo sapiens_hsa049120.75095478
85Measles_Homo sapiens_hsa051620.74975237
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74640270
87Phenylalanine metabolism_Homo sapiens_hsa003600.74569600
88Salivary secretion_Homo sapiens_hsa049700.74055698
89Epstein-Barr virus infection_Homo sapiens_hsa051690.74014542
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73516641
91cAMP signaling pathway_Homo sapiens_hsa040240.73107586
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71911232
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71377961
94Acute myeloid leukemia_Homo sapiens_hsa052210.71168739
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70963039
96Oocyte meiosis_Homo sapiens_hsa041140.68863608
97Butanoate metabolism_Homo sapiens_hsa006500.65046029
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64813162
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64403938
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.63892739
101N-Glycan biosynthesis_Homo sapiens_hsa005100.61581224
102Hippo signaling pathway_Homo sapiens_hsa043900.61406634
103Pathways in cancer_Homo sapiens_hsa052000.60007129
104GABAergic synapse_Homo sapiens_hsa047270.59515363
105Nitrogen metabolism_Homo sapiens_hsa009100.58475350
106Dopaminergic synapse_Homo sapiens_hsa047280.58325535
107Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56686238
108Adherens junction_Homo sapiens_hsa045200.56608091
109MicroRNAs in cancer_Homo sapiens_hsa052060.55349744
110Lysine degradation_Homo sapiens_hsa003100.54674793
111Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54246503
112HIF-1 signaling pathway_Homo sapiens_hsa040660.54201416
113Galactose metabolism_Homo sapiens_hsa000520.53734795
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53717266
115Regulation of autophagy_Homo sapiens_hsa041400.53573237
116Small cell lung cancer_Homo sapiens_hsa052220.53482119
117Long-term depression_Homo sapiens_hsa047300.53431332
118Starch and sucrose metabolism_Homo sapiens_hsa005000.53403863
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.52945688
120Sulfur relay system_Homo sapiens_hsa041220.52914808
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50467720
122Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50051272
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.49934984
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49245419
125Leishmaniasis_Homo sapiens_hsa051400.48451639
126MAPK signaling pathway_Homo sapiens_hsa040100.48309963
127Olfactory transduction_Homo sapiens_hsa047400.47990185
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47319566
129Viral carcinogenesis_Homo sapiens_hsa052030.46887635
130Hematopoietic cell lineage_Homo sapiens_hsa046400.46369302
131Gap junction_Homo sapiens_hsa045400.46179819
132Allograft rejection_Homo sapiens_hsa053300.45894452
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44500801
134mTOR signaling pathway_Homo sapiens_hsa041500.43800879
135Other glycan degradation_Homo sapiens_hsa005110.43254662
136Arachidonic acid metabolism_Homo sapiens_hsa005900.43192150
137Circadian rhythm_Homo sapiens_hsa047100.42987690
138Antigen processing and presentation_Homo sapiens_hsa046120.42788405
139Glioma_Homo sapiens_hsa052140.42739498
140Pancreatic secretion_Homo sapiens_hsa049720.41023527
141Type II diabetes mellitus_Homo sapiens_hsa049300.40914371
142Glutamatergic synapse_Homo sapiens_hsa047240.40120353
143FoxO signaling pathway_Homo sapiens_hsa040680.38627669
144Asthma_Homo sapiens_hsa053100.38450049
145Focal adhesion_Homo sapiens_hsa045100.37538862
146Carbon metabolism_Homo sapiens_hsa012000.37298389
147Legionellosis_Homo sapiens_hsa051340.37114806
148Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37064223
149Central carbon metabolism in cancer_Homo sapiens_hsa052300.36898986
150Melanogenesis_Homo sapiens_hsa049160.36700512
151Hepatitis B_Homo sapiens_hsa051610.36549518
152AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36195275
153Leukocyte transendothelial migration_Homo sapiens_hsa046700.35896837
154Nicotine addiction_Homo sapiens_hsa050330.35466074
155Morphine addiction_Homo sapiens_hsa050320.33204235
156Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32837599
157TGF-beta signaling pathway_Homo sapiens_hsa043500.32710589
158Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32148315
159PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31901190
160Insulin signaling pathway_Homo sapiens_hsa049100.31575783
161Taste transduction_Homo sapiens_hsa047420.31244947
162Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30579841
163Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29607260
164VEGF signaling pathway_Homo sapiens_hsa043700.29300295
165Bile secretion_Homo sapiens_hsa049760.29183497
166PPAR signaling pathway_Homo sapiens_hsa033200.29176617
167Colorectal cancer_Homo sapiens_hsa052100.28957993
168Chronic myeloid leukemia_Homo sapiens_hsa052200.28435003
169Ovarian steroidogenesis_Homo sapiens_hsa049130.28224519
170Influenza A_Homo sapiens_hsa051640.27171509
171Tight junction_Homo sapiens_hsa045300.27094796
172beta-Alanine metabolism_Homo sapiens_hsa004100.26629694
173ECM-receptor interaction_Homo sapiens_hsa045120.25929478
174Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22785704

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