CAMLG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)3.89557690
2establishment of protein localization to mitochondrial membrane (GO:0090151)3.81677916
3mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.65653189
4mitochondrial respiratory chain complex I assembly (GO:0032981)3.65653189
5NADH dehydrogenase complex assembly (GO:0010257)3.65653189
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.61195720
7protein complex biogenesis (GO:0070271)3.57759102
8protein neddylation (GO:0045116)3.53626603
9presynaptic membrane assembly (GO:0097105)3.49161339
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.43782161
11protein-cofactor linkage (GO:0018065)3.40680744
12mitochondrial respiratory chain complex assembly (GO:0033108)3.36611601
13nonmotile primary cilium assembly (GO:0035058)3.36287510
14chaperone-mediated protein transport (GO:0072321)3.28364147
15water-soluble vitamin biosynthetic process (GO:0042364)3.26399729
16ATP synthesis coupled proton transport (GO:0015986)3.26286459
17energy coupled proton transport, down electrochemical gradient (GO:0015985)3.26286459
18anterograde axon cargo transport (GO:0008089)3.23633686
19neuron cell-cell adhesion (GO:0007158)3.17138136
20presynaptic membrane organization (GO:0097090)3.13908424
21anterograde synaptic vesicle transport (GO:0048490)3.11616098
22positive regulation of mitochondrial fission (GO:0090141)3.09377145
23nucleobase catabolic process (GO:0046113)3.07566415
24respiratory electron transport chain (GO:0022904)3.04366902
25electron transport chain (GO:0022900)3.00461332
26termination of RNA polymerase III transcription (GO:0006386)2.98336020
27transcription elongation from RNA polymerase III promoter (GO:0006385)2.98336020
28postsynaptic membrane organization (GO:0001941)2.94648862
29neuronal action potential propagation (GO:0019227)2.92097939
30cullin deneddylation (GO:0010388)2.91478227
31neurofilament cytoskeleton organization (GO:0060052)2.90431230
32regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.89239844
33ribonucleoprotein complex disassembly (GO:0032988)2.83140190
34regulation of synapse structural plasticity (GO:0051823)2.82355131
35organelle disassembly (GO:1903008)2.82343591
36nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.79772665
37platelet dense granule organization (GO:0060155)2.77773474
38negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.77413319
39intracellular protein transmembrane import (GO:0044743)2.77002381
40exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.74016610
41translational termination (GO:0006415)2.70568008
42viral transcription (GO:0019083)2.70423032
43epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.70211721
44establishment of protein localization to mitochondrion (GO:0072655)2.68804154
45regulation of cilium movement (GO:0003352)2.66943048
46retinal cone cell development (GO:0046549)2.66650591
47intraciliary transport (GO:0042073)2.66106983
48substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.65862469
49substrate-independent telencephalic tangential migration (GO:0021826)2.65862469
50cilium morphogenesis (GO:0060271)2.65492661
51negative regulation of transcription regulatory region DNA binding (GO:2000678)2.64745302
52protein localization to mitochondrion (GO:0070585)2.63366804
53ribosomal large subunit biogenesis (GO:0042273)2.63351178
54positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.63294573
55synaptic transmission, glutamatergic (GO:0035249)2.63121694
56protein targeting to mitochondrion (GO:0006626)2.61874270
57synaptic vesicle maturation (GO:0016188)2.61852210
58ribosomal small subunit assembly (GO:0000028)2.61149916
59protein localization to cilium (GO:0061512)2.59590900
60protein deneddylation (GO:0000338)2.58597285
61neuron-neuron synaptic transmission (GO:0007270)2.58237389
62negative regulation of response to food (GO:0032096)2.56507467
63negative regulation of appetite (GO:0032099)2.56507467
64ubiquinone metabolic process (GO:0006743)2.56401607
65regulation of microtubule-based movement (GO:0060632)2.55871872
66behavioral response to nicotine (GO:0035095)2.55676775
67cotranslational protein targeting to membrane (GO:0006613)2.54780755
68ubiquinone biosynthetic process (GO:0006744)2.53370880
69iron-sulfur cluster assembly (GO:0016226)2.53296110
70metallo-sulfur cluster assembly (GO:0031163)2.53296110
71establishment of mitochondrion localization (GO:0051654)2.52820579
72piRNA metabolic process (GO:0034587)2.52742457
73neurotransmitter-gated ion channel clustering (GO:0072578)2.51562774
74tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.51321181
75RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.51321181
76SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.51134789
77auditory behavior (GO:0031223)2.50940818
78epithelial cilium movement (GO:0003351)2.50082974
79translational elongation (GO:0006414)2.49126734
80retinal ganglion cell axon guidance (GO:0031290)2.46098233
81negative regulation of membrane potential (GO:0045837)2.46050190
82protein targeting to ER (GO:0045047)2.45831927
83protein localization to synapse (GO:0035418)2.45363128
84ionotropic glutamate receptor signaling pathway (GO:0035235)2.43902598
85short-term memory (GO:0007614)2.42729998
86positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.41175885
87respiratory chain complex IV assembly (GO:0008535)2.41061001
88intracellular protein transmembrane transport (GO:0065002)2.40934056
89hydrogen ion transmembrane transport (GO:1902600)2.39413588
90proteasome assembly (GO:0043248)2.39283206
91establishment of protein localization to endoplasmic reticulum (GO:0072599)2.39191819
92protein localization to endoplasmic reticulum (GO:0070972)2.38484031
93DNA damage response, detection of DNA damage (GO:0042769)2.37000840
94synapse assembly (GO:0007416)2.36481464
95establishment of melanosome localization (GO:0032401)2.34545146
96epithelial cell differentiation involved in kidney development (GO:0035850)2.32283901
97axonal fasciculation (GO:0007413)2.32019004
98negative regulation of synaptic transmission, GABAergic (GO:0032229)2.31936697
99neuron fate determination (GO:0048664)2.31560573
100melanosome transport (GO:0032402)2.30780135

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.30486825
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.00103366
3GABP_17652178_ChIP-ChIP_JURKAT_Human2.95051916
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.94787931
5ZNF274_21170338_ChIP-Seq_K562_Hela2.91478499
6GBX2_23144817_ChIP-Seq_PC3_Human2.81905629
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.70044380
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.48452664
9IGF1R_20145208_ChIP-Seq_DFB_Human2.40129512
10TAF15_26573619_Chip-Seq_HEK293_Human2.28183648
11FUS_26573619_Chip-Seq_HEK293_Human2.26139058
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.18034551
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.14921550
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14272366
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.10044761
16EWS_26573619_Chip-Seq_HEK293_Human2.08061104
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03201455
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.02364667
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96123932
20CREB1_15753290_ChIP-ChIP_HEK293T_Human1.91853598
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88010064
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.83813521
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.83741846
24VDR_22108803_ChIP-Seq_LS180_Human1.81772591
25VDR_23849224_ChIP-Seq_CD4+_Human1.79358834
26P300_19829295_ChIP-Seq_ESCs_Human1.79027667
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77896595
28RNF2_27304074_Chip-Seq_NSC_Mouse1.76261412
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74559617
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.73743519
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72902402
32REST_21632747_ChIP-Seq_MESCs_Mouse1.71564681
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67891591
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66792307
35MYC_18940864_ChIP-ChIP_HL60_Human1.66566601
36ELK1_19687146_ChIP-ChIP_HELA_Human1.65634714
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65012065
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64651968
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58145288
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54130650
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50201298
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49252855
43REST_18959480_ChIP-ChIP_MESCs_Mouse1.47073731
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.44886407
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43973973
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.43187808
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42891366
48IRF1_19129219_ChIP-ChIP_H3396_Human1.39544501
49FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.39079345
50TP53_22573176_ChIP-Seq_HFKS_Human1.36635454
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.28896017
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.26761191
53EED_16625203_ChIP-ChIP_MESCs_Mouse1.25802270
54TTF2_22483619_ChIP-Seq_HELA_Human1.23494612
55* FOXP3_21729870_ChIP-Seq_TREG_Human1.22830979
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20349199
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.19957695
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18420491
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.17791366
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.17255530
61JARID2_20064375_ChIP-Seq_MESCs_Mouse1.14790276
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14649272
63CBP_20019798_ChIP-Seq_JUKART_Human1.14649272
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13240249
65SMAD4_21799915_ChIP-Seq_A2780_Human1.12374963
66SOX2_16153702_ChIP-ChIP_HESCs_Human1.11461603
67GABP_19822575_ChIP-Seq_HepG2_Human1.11282364
68SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.10270436
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09708448
70MYC_18555785_ChIP-Seq_MESCs_Mouse1.09162259
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09058761
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.08982360
73AR_25329375_ChIP-Seq_VCAP_Human1.08262559
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07596206
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06837234
76RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06744710
77ER_23166858_ChIP-Seq_MCF-7_Human1.05850671
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02514516
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.02352224
80TAL1_26923725_Chip-Seq_HPCs_Mouse1.01418246
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00777035
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00676148
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00563558
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00280628
85PIAS1_25552417_ChIP-Seq_VCAP_Human0.98940685
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98465756
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98465756
88KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98005985
89REST_19997604_ChIP-ChIP_NEURONS_Mouse0.96237306
90RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95930877
91DCP1A_22483619_ChIP-Seq_HELA_Human0.95863934
92HTT_18923047_ChIP-ChIP_STHdh_Human0.94266224
93SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93007407
94SOX2_19829295_ChIP-Seq_ESCs_Human0.91672226
95NANOG_19829295_ChIP-Seq_ESCs_Human0.91672226
96SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91398077
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91130180
98KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90976937
99YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90349682
100EZH2_27294783_Chip-Seq_ESCs_Mouse0.90115706

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern2.95466709
2MP0001529_abnormal_vocalization2.61975361
3MP0003787_abnormal_imprinting2.48496770
4MP0004859_abnormal_synaptic_plasticity2.42026451
5MP0008877_abnormal_DNA_methylation2.36002314
6MP0002102_abnormal_ear_morphology2.34127526
7MP0006276_abnormal_autonomic_nervous2.22568362
8MP0002272_abnormal_nervous_system2.22426131
9MP0001984_abnormal_olfaction2.22058519
10MP0006292_abnormal_olfactory_placode2.17849777
11MP0002822_catalepsy2.17849515
12MP0009046_muscle_twitch2.15393323
13MP0001188_hyperpigmentation2.10477501
14MP0003635_abnormal_synaptic_transmissio2.09081988
15MP0005423_abnormal_somatic_nervous2.00563449
16MP0009745_abnormal_behavioral_response1.99711305
17MP0000778_abnormal_nervous_system1.98837906
18MP0001968_abnormal_touch/_nociception1.95046813
19MP0008789_abnormal_olfactory_epithelium1.94115485
20MP0002735_abnormal_chemical_nociception1.90373994
21MP0004270_analgesia1.87557801
22MP0002837_dystrophic_cardiac_calcinosis1.85995227
23MP0002736_abnormal_nociception_after1.84774593
24MP0002653_abnormal_ependyma_morphology1.84322843
25MP0009379_abnormal_foot_pigmentation1.84202297
26MP0002572_abnormal_emotion/affect_behav1.83412900
27MP0001486_abnormal_startle_reflex1.82666887
28MP0005499_abnormal_olfactory_system1.78812050
29MP0005394_taste/olfaction_phenotype1.78812050
30MP0002063_abnormal_learning/memory/cond1.73293675
31MP0002734_abnormal_mechanical_nocicepti1.73068318
32MP0002064_seizures1.67699241
33MP0003121_genomic_imprinting1.66320455
34MP0002557_abnormal_social/conspecific_i1.63650981
35MP0004142_abnormal_muscle_tone1.63609007
36MP0005551_abnormal_eye_electrophysiolog1.59349765
37MP0008058_abnormal_DNA_repair1.55458691
38MP0002638_abnormal_pupillary_reflex1.55041584
39MP0000631_abnormal_neuroendocrine_gland1.53843546
40MP0003136_yellow_coat_color1.53124154
41MP0003122_maternal_imprinting1.49924819
42MP0001970_abnormal_pain_threshold1.44524740
43MP0006072_abnormal_retinal_apoptosis1.44192701
44MP0001905_abnormal_dopamine_level1.38692258
45MP0005645_abnormal_hypothalamus_physiol1.37026148
46MP0004885_abnormal_endolymph1.35765316
47MP0005646_abnormal_pituitary_gland1.34474853
48MP0000955_abnormal_spinal_cord1.33815657
49MP0002067_abnormal_sensory_capabilities1.33183161
50MP0003718_maternal_effect1.32131431
51MP0001986_abnormal_taste_sensitivity1.31596831
52MP0000049_abnormal_middle_ear1.29148747
53MP0002184_abnormal_innervation1.21464989
54MP0002733_abnormal_thermal_nociception1.21448816
55MP0004924_abnormal_behavior1.21224389
56MP0005386_behavior/neurological_phenoty1.21224389
57MP0003890_abnormal_embryonic-extraembry1.18970064
58MP0006035_abnormal_mitochondrial_morpho1.18946645
59MP0005084_abnormal_gallbladder_morpholo1.18774107
60MP0002882_abnormal_neuron_morphology1.18691063
61MP0001485_abnormal_pinna_reflex1.17445052
62MP0004742_abnormal_vestibular_system1.16736867
63MP0001293_anophthalmia1.16461913
64MP0002234_abnormal_pharynx_morphology1.16235956
65MP0005253_abnormal_eye_physiology1.11893511
66MP0005187_abnormal_penis_morphology1.11804453
67MP0001501_abnormal_sleep_pattern1.10823063
68MP0002752_abnormal_somatic_nervous1.10612545
69MP0002938_white_spotting1.08903153
70MP0002163_abnormal_gland_morphology1.06925532
71MP0003646_muscle_fatigue1.03818223
72MP0004811_abnormal_neuron_physiology1.03471410
73MP0004133_heterotaxia1.03274465
74MP0002160_abnormal_reproductive_system1.02370518
75MP0001502_abnormal_circadian_rhythm1.00848060
76MP0002152_abnormal_brain_morphology0.97720245
77MP0003123_paternal_imprinting0.96707478
78MP0008995_early_reproductive_senescence0.96403389
79MP0003567_abnormal_fetal_cardiomyocyte0.94760654
80MP0006036_abnormal_mitochondrial_physio0.94646614
81MP0001440_abnormal_grooming_behavior0.94291099
82MP0000026_abnormal_inner_ear0.93987931
83MP0002210_abnormal_sex_determination0.93456474
84MP0002066_abnormal_motor_capabilities/c0.92730205
85MP0002751_abnormal_autonomic_nervous0.92549824
86MP0003011_delayed_dark_adaptation0.91561203
87MP0003698_abnormal_male_reproductive0.89716795
88MP0005379_endocrine/exocrine_gland_phen0.89236546
89MP0004145_abnormal_muscle_electrophysio0.87366409
90MP0003186_abnormal_redox_activity0.86944346
91MP0002909_abnormal_adrenal_gland0.86047683
92MP0002928_abnormal_bile_duct0.85911075
93MP0004215_abnormal_myocardial_fiber0.85806069
94MP0005195_abnormal_posterior_eye0.85229348
95MP0001929_abnormal_gametogenesis0.84273911
96MP0001963_abnormal_hearing_physiology0.82635423
97MP0002229_neurodegeneration0.81290437
98MP0003861_abnormal_nervous_system0.80115287
99MP0003937_abnormal_limbs/digits/tail_de0.80111772
100MP0002233_abnormal_nose_morphology0.78253929

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.91688021
2Medial flaring of the eyebrow (HP:0010747)3.60950654
3Molar tooth sign on MRI (HP:0002419)3.56865646
4Abnormality of midbrain morphology (HP:0002418)3.56865646
5Abnormal mitochondria in muscle tissue (HP:0008316)3.52390469
6Myokymia (HP:0002411)3.49906319
7Gait imbalance (HP:0002141)3.39393444
8Acute encephalopathy (HP:0006846)3.37628508
9Progressive macrocephaly (HP:0004481)3.35979146
10Mitochondrial inheritance (HP:0001427)3.21474789
11Limb dystonia (HP:0002451)3.19658926
12Pancreatic cysts (HP:0001737)3.19330525
13Congenital primary aphakia (HP:0007707)3.12673796
14Pancreatic fibrosis (HP:0100732)3.12196779
15Nephrogenic diabetes insipidus (HP:0009806)3.07807551
16Increased CSF lactate (HP:0002490)2.92260920
17Type II lissencephaly (HP:0007260)2.88655406
18Methylmalonic acidemia (HP:0002912)2.86596419
19True hermaphroditism (HP:0010459)2.80484106
20Increased hepatocellular lipid droplets (HP:0006565)2.77916873
21Focal motor seizures (HP:0011153)2.75062367
22Retinal dysplasia (HP:0007973)2.68430873
23Hepatic necrosis (HP:0002605)2.62184060
24Febrile seizures (HP:0002373)2.61226567
25Nephronophthisis (HP:0000090)2.59958059
26Atonic seizures (HP:0010819)2.59133213
27Lipid accumulation in hepatocytes (HP:0006561)2.56772123
28Hyperglycinemia (HP:0002154)2.51959751
29Hepatocellular necrosis (HP:0001404)2.50767911
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.50385008
31Decreased activity of mitochondrial respiratory chain (HP:0008972)2.50385008
32Polyphagia (HP:0002591)2.46307949
33Genital tract atresia (HP:0001827)2.45957205
343-Methylglutaconic aciduria (HP:0003535)2.43668828
35Lissencephaly (HP:0001339)2.40576317
36Vaginal atresia (HP:0000148)2.38092287
37Cerebral edema (HP:0002181)2.31191133
38Pachygyria (HP:0001302)2.27868415
39Sclerocornea (HP:0000647)2.26185610
40Abnormality of alanine metabolism (HP:0010916)2.23616699
41Hyperalaninemia (HP:0003348)2.23616699
42Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.23616699
43Increased intramyocellular lipid droplets (HP:0012240)2.23469966
44Methylmalonic aciduria (HP:0012120)2.20568984
45Renal Fanconi syndrome (HP:0001994)2.20440030
46Focal seizures (HP:0007359)2.16640979
47Renal cortical cysts (HP:0000803)2.14199078
48Absent rod-and cone-mediated responses on ERG (HP:0007688)2.14097105
49Abnormality of the labia minora (HP:0012880)2.11795445
50Optic disc pallor (HP:0000543)2.11148643
51Adrenal hypoplasia (HP:0000835)2.10932938
52Cerebral hypomyelination (HP:0006808)2.07432301
53Specific learning disability (HP:0001328)2.06118071
54Poor coordination (HP:0002370)2.06078076
55Abnormality of cells of the erythroid lineage (HP:0012130)2.05970966
56Abnormal number of erythroid precursors (HP:0012131)2.02468485
57Septo-optic dysplasia (HP:0100842)2.01570643
58Lactic acidosis (HP:0003128)2.01295229
59CNS hypomyelination (HP:0003429)1.96940699
60Epileptic encephalopathy (HP:0200134)1.96007801
61Abnormal rod and cone electroretinograms (HP:0008323)1.95020860
62Increased serum lactate (HP:0002151)1.94271947
63Dialeptic seizures (HP:0011146)1.93618831
64Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.92839991
65Degeneration of the lateral corticospinal tracts (HP:0002314)1.92839991
66Generalized tonic-clonic seizures (HP:0002069)1.92821803
67Chronic hepatic failure (HP:0100626)1.91118678
68Poor suck (HP:0002033)1.89725332
69Spastic tetraplegia (HP:0002510)1.89534700
70Optic nerve hypoplasia (HP:0000609)1.89172627
71Abnormality of the corticospinal tract (HP:0002492)1.88348538
72Abnormality of the renal medulla (HP:0100957)1.87749434
73Cystic liver disease (HP:0006706)1.87622700
74Inability to walk (HP:0002540)1.87166977
75Anencephaly (HP:0002323)1.85974267
76Short tibia (HP:0005736)1.84913365
77Absence seizures (HP:0002121)1.84750374
78Aplasia/Hypoplasia of the tongue (HP:0010295)1.84409410
79Occipital encephalocele (HP:0002085)1.83897868
80Congenital stationary night blindness (HP:0007642)1.83338152
81Drooling (HP:0002307)1.81189231
82Leukodystrophy (HP:0002415)1.80477386
83Postaxial hand polydactyly (HP:0001162)1.79208580
84Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74781829
85Decreased testicular size (HP:0008734)1.74351574
86Increased muscle lipid content (HP:0009058)1.74190973
87Narrow forehead (HP:0000341)1.73060351
88Muscular hypotonia of the trunk (HP:0008936)1.72207039
89Intestinal atresia (HP:0011100)1.71999772
90Aplasia/Hypoplasia of the tibia (HP:0005772)1.71886715
91Postaxial foot polydactyly (HP:0001830)1.71817972
92Colon cancer (HP:0003003)1.71778130
93Progressive cerebellar ataxia (HP:0002073)1.71770413
94Median cleft lip (HP:0000161)1.71064266
95Abnormality of the renal cortex (HP:0011035)1.69688737
96Macrocytic anemia (HP:0001972)1.69462174
97Bifid tongue (HP:0010297)1.68038833
98Lethargy (HP:0001254)1.67184610
99Broad-based gait (HP:0002136)1.66715753
100Metaphyseal dysplasia (HP:0100255)1.65791532

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.03505614
2CASK3.02019453
3CDK192.63421797
4MAP4K22.60347329
5MAP3K42.47712986
6MAP2K72.28272068
7DYRK22.17534139
8WNK32.05133060
9STK162.03700691
10TRIM282.01125692
11BCR1.98320634
12CSNK1G21.91058897
13PINK11.86031605
14MAPK131.82626415
15BCKDK1.81690773
16ARAF1.79527899
17EPHA41.78984797
18BMPR1B1.72063654
19CSNK1G31.71609518
20ZAK1.67936752
21PNCK1.61563400
22TLK11.60934869
23CSNK1G11.53596638
24ADRBK21.53000914
25GRK11.43637948
26PRKCG1.41457547
27ERBB31.41443104
28FRK1.40187073
29CSNK1A1L1.29639973
30MINK11.29599098
31NUAK11.27408899
32PHKG11.26695705
33PHKG21.26695705
34VRK11.24845688
35NTRK21.23080102
36CAMKK21.19193141
37TNIK1.19020013
38MAP3K91.14910715
39DYRK31.07504485
40PLK21.06417420
41SRPK11.05819134
42BRAF1.05580293
43PIM21.03759980
44NTRK31.00081611
45EIF2AK31.00021489
46PAK30.98127147
47MAPKAPK50.97886755
48CAMK2A0.92633135
49UHMK10.91690622
50PRKCE0.91199272
51RPS6KA50.87546029
52BUB10.86901826
53MKNK20.86153681
54LIMK10.86123103
55WNK40.84392625
56PLK30.83623766
57DAPK20.82506923
58MKNK10.80602819
59MAP2K40.79263129
60CDK30.79217412
61PAK60.74626980
62VRK20.72965538
63SIK20.71283475
64PKN10.70963153
65CDK50.70672453
66TSSK60.68037021
67CCNB10.67968164
68PLK40.65421191
69EPHB20.64685370
70DYRK1A0.63997282
71OXSR10.63354200
72PLK10.62957173
73RPS6KA40.62678411
74CDK140.59472357
75CSNK1E0.58463793
76NEK10.57014538
77WEE10.56811382
78TAOK30.55464508
79PASK0.54575964
80PRKCI0.53968324
81AURKA0.53290546
82PRKACA0.52694384
83KSR10.51573115
84ACVR1B0.50904763
85ADRBK10.48898387
86GRK50.48731703
87RAF10.47239759
88CDK11A0.46044538
89CSNK1A10.45050436
90CDK180.44971039
91INSRR0.44794374
92TIE10.43592224
93TGFBR10.42298262
94CAMK10.41328657
95CDK150.40341856
96PRKCZ0.39633970
97DYRK1B0.39558993
98PRKG10.38970102
99CSNK2A20.38957073
100CSNK1D0.38899705

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.93360782
2Parkinsons disease_Homo sapiens_hsa050123.39348055
3Ribosome_Homo sapiens_hsa030103.12151793
4Protein export_Homo sapiens_hsa030603.05110277
5Nicotine addiction_Homo sapiens_hsa050332.94487959
6RNA polymerase_Homo sapiens_hsa030202.46714469
7Huntingtons disease_Homo sapiens_hsa050162.33584921
8Alzheimers disease_Homo sapiens_hsa050102.26421058
9Cardiac muscle contraction_Homo sapiens_hsa042602.23057622
10Phototransduction_Homo sapiens_hsa047441.97934009
11Basal transcription factors_Homo sapiens_hsa030221.97501796
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.93965417
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.87543582
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81233331
15Synaptic vesicle cycle_Homo sapiens_hsa047211.77275552
16GABAergic synapse_Homo sapiens_hsa047271.76796657
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.73080325
18Proteasome_Homo sapiens_hsa030501.69616971
19Collecting duct acid secretion_Homo sapiens_hsa049661.64807988
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.61707358
21RNA degradation_Homo sapiens_hsa030181.61467800
22Morphine addiction_Homo sapiens_hsa050321.54160094
23Regulation of autophagy_Homo sapiens_hsa041401.47580514
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.45456615
25Propanoate metabolism_Homo sapiens_hsa006401.41332631
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.41233816
27Dopaminergic synapse_Homo sapiens_hsa047281.35351773
28Glutamatergic synapse_Homo sapiens_hsa047241.27437826
29Mismatch repair_Homo sapiens_hsa034301.27288353
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27214252
31Circadian entrainment_Homo sapiens_hsa047131.23491446
32Cocaine addiction_Homo sapiens_hsa050301.21372714
33Steroid biosynthesis_Homo sapiens_hsa001001.20895691
34Amphetamine addiction_Homo sapiens_hsa050311.16922339
35Selenocompound metabolism_Homo sapiens_hsa004501.14207404
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13323247
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12921772
38Folate biosynthesis_Homo sapiens_hsa007901.12223214
39Insulin secretion_Homo sapiens_hsa049111.11584631
40Homologous recombination_Homo sapiens_hsa034401.10180083
41Taste transduction_Homo sapiens_hsa047421.08176387
42Fatty acid elongation_Homo sapiens_hsa000621.06863627
43Butanoate metabolism_Homo sapiens_hsa006501.04425457
44Nucleotide excision repair_Homo sapiens_hsa034201.03810805
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.01178727
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01129922
47Purine metabolism_Homo sapiens_hsa002301.01090629
48RNA transport_Homo sapiens_hsa030131.01048729
49Spliceosome_Homo sapiens_hsa030400.97661200
50Serotonergic synapse_Homo sapiens_hsa047260.96230026
51Pyrimidine metabolism_Homo sapiens_hsa002400.95639622
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.95269437
53Fanconi anemia pathway_Homo sapiens_hsa034600.92748821
54Olfactory transduction_Homo sapiens_hsa047400.92519116
55Sulfur relay system_Homo sapiens_hsa041220.92510613
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88520453
57Linoleic acid metabolism_Homo sapiens_hsa005910.86393657
58One carbon pool by folate_Homo sapiens_hsa006700.79140546
59Oocyte meiosis_Homo sapiens_hsa041140.78603321
60Peroxisome_Homo sapiens_hsa041460.77294948
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76080432
62Pyruvate metabolism_Homo sapiens_hsa006200.75084735
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74740881
64Nitrogen metabolism_Homo sapiens_hsa009100.74347480
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72589187
66Base excision repair_Homo sapiens_hsa034100.70261641
67Metabolic pathways_Homo sapiens_hsa011000.70170778
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.67836820
69Long-term depression_Homo sapiens_hsa047300.67705719
70Circadian rhythm_Homo sapiens_hsa047100.66256971
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64585508
72Non-homologous end-joining_Homo sapiens_hsa034500.63244152
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63094741
74Alcoholism_Homo sapiens_hsa050340.61609108
75Ether lipid metabolism_Homo sapiens_hsa005650.57947929
76Cholinergic synapse_Homo sapiens_hsa047250.56368950
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53758061
78Vibrio cholerae infection_Homo sapiens_hsa051100.48795387
79Hedgehog signaling pathway_Homo sapiens_hsa043400.48763473
80beta-Alanine metabolism_Homo sapiens_hsa004100.47805107
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47273735
82mRNA surveillance pathway_Homo sapiens_hsa030150.46546849
83Calcium signaling pathway_Homo sapiens_hsa040200.43826928
84Arginine and proline metabolism_Homo sapiens_hsa003300.43617686
85Axon guidance_Homo sapiens_hsa043600.42806701
86Sulfur metabolism_Homo sapiens_hsa009200.42660709
87Salivary secretion_Homo sapiens_hsa049700.40266210
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38963197
89Oxytocin signaling pathway_Homo sapiens_hsa049210.38913654
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35054095
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33417781
92cAMP signaling pathway_Homo sapiens_hsa040240.33270496
93Tryptophan metabolism_Homo sapiens_hsa003800.32933715
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31994535
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31047519
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.29819640
97DNA replication_Homo sapiens_hsa030300.28788795
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28574240
99p53 signaling pathway_Homo sapiens_hsa041150.26625004
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26018044

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