CAMKK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)6.28629197
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.18795739
3synaptic vesicle maturation (GO:0016188)6.16535775
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.00886170
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.44039202
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.41396670
7vocalization behavior (GO:0071625)5.33996919
8synaptic vesicle docking involved in exocytosis (GO:0016081)5.33293346
9synaptic vesicle exocytosis (GO:0016079)5.28959179
10glutamate secretion (GO:0014047)5.06410760
11regulation of glutamate receptor signaling pathway (GO:1900449)5.03582001
12regulation of synaptic vesicle exocytosis (GO:2000300)4.96546472
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.79469163
14neuronal action potential propagation (GO:0019227)4.77923730
15regulation of synapse structural plasticity (GO:0051823)4.77461394
16regulation of long-term neuronal synaptic plasticity (GO:0048169)4.66126120
17layer formation in cerebral cortex (GO:0021819)4.53501703
18exploration behavior (GO:0035640)4.45496615
19regulation of neuronal synaptic plasticity (GO:0048168)4.45367820
20neurotransmitter secretion (GO:0007269)4.39360198
21protein localization to synapse (GO:0035418)4.39273641
22regulation of synaptic vesicle transport (GO:1902803)4.38680396
23glutamate receptor signaling pathway (GO:0007215)4.24767847
24amino acid import (GO:0043090)4.22177761
25synaptic transmission, glutamatergic (GO:0035249)4.21706977
26dendritic spine morphogenesis (GO:0060997)4.14986565
27cellular potassium ion homeostasis (GO:0030007)4.11647096
28regulation of excitatory postsynaptic membrane potential (GO:0060079)4.07576532
29long-term memory (GO:0007616)4.03552090
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.98457613
31neurotransmitter-gated ion channel clustering (GO:0072578)3.96286774
32regulation of dendritic spine morphogenesis (GO:0061001)3.94499401
33gamma-aminobutyric acid transport (GO:0015812)3.94252607
34neuron-neuron synaptic transmission (GO:0007270)3.93353984
35sodium ion export (GO:0071436)3.93305925
36neuromuscular process controlling balance (GO:0050885)3.89024093
37positive regulation of membrane potential (GO:0045838)3.88926519
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.83991616
39G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.81936530
40regulation of postsynaptic membrane potential (GO:0060078)3.81143258
41regulation of synapse maturation (GO:0090128)3.71807520
42positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.68371853
43regulation of synaptic plasticity (GO:0048167)3.67626935
44activation of protein kinase A activity (GO:0034199)3.64788088
45positive regulation of neurotransmitter secretion (GO:0001956)3.63766212
46positive regulation of synapse maturation (GO:0090129)3.62946796
47cerebellar Purkinje cell differentiation (GO:0021702)3.62896599
48prepulse inhibition (GO:0060134)3.61838317
49potassium ion homeostasis (GO:0055075)3.60185326
50synaptic vesicle endocytosis (GO:0048488)3.56429309
51regulation of ARF protein signal transduction (GO:0032012)3.55708002
52positive regulation of neurotransmitter transport (GO:0051590)3.54085099
53auditory behavior (GO:0031223)3.49838581
54proline transport (GO:0015824)3.46703023
55regulation of neurotransmitter secretion (GO:0046928)3.45424494
56neuronal ion channel clustering (GO:0045161)3.39949662
57negative regulation of dendrite morphogenesis (GO:0050774)3.39765735
58positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.39610255
59neuron cell-cell adhesion (GO:0007158)3.39096881
60regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.37699514
61regulation of dendritic spine development (GO:0060998)3.35692018
62gamma-aminobutyric acid signaling pathway (GO:0007214)3.34294805
63regulation of synaptic transmission, glutamatergic (GO:0051966)3.34002927
64regulation of voltage-gated calcium channel activity (GO:1901385)3.33879312
65neurotransmitter transport (GO:0006836)3.31588697
66G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.27491989
67long-term synaptic potentiation (GO:0060291)3.26571693
68membrane depolarization (GO:0051899)3.26271073
69transmission of nerve impulse (GO:0019226)3.23494497
70response to auditory stimulus (GO:0010996)3.23260005
71regulation of neurotransmitter transport (GO:0051588)3.19881241
72regulation of neurotransmitter levels (GO:0001505)3.18780325
73cellular sodium ion homeostasis (GO:0006883)3.18060617
74cerebellar granule cell differentiation (GO:0021707)3.16175246
75positive regulation of dendritic spine development (GO:0060999)3.15161987
76membrane depolarization during action potential (GO:0086010)3.14020294
77L-amino acid import (GO:0043092)3.11308821
78dendrite morphogenesis (GO:0048813)3.10926723
79positive regulation of dendritic spine morphogenesis (GO:0061003)3.09186157
80membrane hyperpolarization (GO:0060081)3.09018445
81glycine transport (GO:0015816)3.07571598
82cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.05311854
83negative regulation of synaptic transmission, GABAergic (GO:0032229)3.03969399
84signal complex assembly (GO:0007172)3.03941327
85behavioral response to cocaine (GO:0048148)3.03918173
86positive regulation of Rap GTPase activity (GO:0032854)3.02856611
87regulation of exocytosis (GO:0017157)3.02313775
88dendritic spine organization (GO:0097061)3.01707324
89vesicle transport along microtubule (GO:0047496)3.00347401
90cell differentiation in hindbrain (GO:0021533)3.00323718
91regulation of vesicle fusion (GO:0031338)3.00225420
92vesicle docking involved in exocytosis (GO:0006904)2.98782497
93neuromuscular process controlling posture (GO:0050884)2.98748683
94negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.95178656
95positive regulation of synaptic transmission (GO:0050806)2.94351042
96axon ensheathment in central nervous system (GO:0032291)2.94023696
97central nervous system myelination (GO:0022010)2.94023696
98neuromuscular process (GO:0050905)2.92744964
99cytoskeletal anchoring at plasma membrane (GO:0007016)2.92636161
100positive regulation of fibroblast migration (GO:0010763)2.90714063
101regulation of clathrin-mediated endocytosis (GO:2000369)2.90500562
102regulation of synaptic transmission (GO:0050804)2.90137275
103positive regulation of synaptic transmission, GABAergic (GO:0032230)2.88830277
104learning (GO:0007612)2.87344531
105cell communication by electrical coupling (GO:0010644)2.86702858
106long term synaptic depression (GO:0060292)2.86564938
107regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.86555027
108neuron recognition (GO:0008038)2.83361999
109establishment of synaptic vesicle localization (GO:0097480)2.81894052
110synaptic vesicle transport (GO:0048489)2.81894052
111response to histamine (GO:0034776)2.81694434
112positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.81173713
113potassium ion import (GO:0010107)2.80796028
114acidic amino acid transport (GO:0015800)2.80659159
115mechanosensory behavior (GO:0007638)2.80626513
116adenosine receptor signaling pathway (GO:0001973)2.80390231
117regulation of Rap GTPase activity (GO:0032317)2.73020183
118peptidyl-tyrosine autophosphorylation (GO:0038083)2.71789746
119positive regulation of exocytosis (GO:0045921)2.69165861
120regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.65427619
121vesicle docking (GO:0048278)2.64435919
122neurotransmitter uptake (GO:0001504)2.63450159
123signal release (GO:0023061)2.60131070
124dicarboxylic acid transport (GO:0006835)2.59848746
125postsynaptic membrane organization (GO:0001941)2.59767729

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.61887809
2RARB_27405468_Chip-Seq_BRAIN_Mouse3.19801506
3DROSHA_22980978_ChIP-Seq_HELA_Human3.03798248
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.96115166
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.93891759
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.93704110
7IKZF1_21737484_ChIP-ChIP_HCT116_Human2.78567518
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.71226829
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.71226829
10GBX2_23144817_ChIP-Seq_PC3_Human2.69494104
11REST_21632747_ChIP-Seq_MESCs_Mouse2.65471687
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.61355936
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.57312818
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.55276279
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.51021494
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48485672
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47585400
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.33763815
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.31603770
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20192229
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.17381898
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.15540348
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.11631656
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.08387507
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85192623
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.83177851
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.80184445
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.72607080
29KDM2B_26808549_Chip-Seq_K562_Human1.66595492
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.65938395
31* TCF7_22412390_ChIP-Seq_EML_Mouse1.63882826
32AR_21572438_ChIP-Seq_LNCaP_Human1.61803864
33GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.57061892
34DNAJC2_21179169_ChIP-ChIP_NT2_Human1.54312407
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52144744
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.51953965
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51653168
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.50513308
39* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44882942
40SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.43623751
41* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41693956
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41505466
43VDR_21846776_ChIP-Seq_THP-1_Human1.41209704
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.39763445
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39660090
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39362990
47WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33286348
48ZFP281_18757296_ChIP-ChIP_E14_Mouse1.32830671
49SMAD4_21799915_ChIP-Seq_A2780_Human1.29560934
50GATA1_19941827_ChIP-Seq_MEL_Mouse1.28903847
51* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.28000344
52RING1B_27294783_Chip-Seq_ESCs_Mouse1.26778774
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22935107
54ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22061833
55* AR_19668381_ChIP-Seq_PC3_Human1.21755062
56TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21345846
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19959821
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.19055817
59SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18987863
60* CREB1_26743006_Chip-Seq_LNCaP_Human1.17406947
61KDM2B_26808549_Chip-Seq_DND41_Human1.16018738
62OCT4_19829295_ChIP-Seq_ESCs_Human1.14773224
63TP53_16413492_ChIP-PET_HCT116_Human1.13741938
64E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13378802
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.12747718
66ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12170925
67P68_20966046_ChIP-Seq_HELA_Human1.11956994
68* VDR_24763502_ChIP-Seq_THP-1_Human1.11580795
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10693799
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10179077
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09478883
72P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08507204
73DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.08261679
74* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08027832
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06890752
76KDM2B_26808549_Chip-Seq_JURKAT_Human1.06823715
77RING1B_27294783_Chip-Seq_NPCs_Mouse1.06307885
78SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06175668
79EGR1_19032775_ChIP-ChIP_M12_Human1.05567116
80* RACK7_27058665_Chip-Seq_MCF-7_Human1.05453687
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04052355
82CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03997366
83SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03108785
84STAT3_23295773_ChIP-Seq_U87_Human1.03096768
85ZNF274_21170338_ChIP-Seq_K562_Hela1.02633822
86RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00621529
87MYC_22102868_ChIP-Seq_BL_Human1.00617922
88SA1_27219007_Chip-Seq_ERYTHROID_Human0.98984005
89SMAD3_21741376_ChIP-Seq_EPCs_Human0.98324376
90LXR_22292898_ChIP-Seq_THP-1_Human0.98203134
91GATA1_19941826_ChIP-Seq_K562_Human0.97859418
92UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97331963
93AR_25329375_ChIP-Seq_VCAP_Human0.97124502
94SMAD3_21741376_ChIP-Seq_ESCs_Human0.94410792
95ELK3_25401928_ChIP-Seq_HUVEC_Human0.94267739
96YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94144136
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94028418
98TET1_21490601_ChIP-Seq_MESCs_Mouse0.93720219
99CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93671778
100* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93312151
101RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93112795
102ARNT_22903824_ChIP-Seq_MCF-7_Human0.93051078
103RXR_22108803_ChIP-Seq_LS180_Human0.92580469
104OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92416334
105* DPY_21335234_ChIP-Seq_ESCs_Mouse0.91605090
106TCF4_23295773_ChIP-Seq_U87_Human0.91294607
107NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91248533
108AHR_22903824_ChIP-Seq_MCF-7_Human0.90960949
109PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.90514366
110PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90381437
111SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90279142
112* CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89582455
113STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.89517003
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89256948
115MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88890960
116TET1_21451524_ChIP-Seq_MESCs_Mouse0.88750254
117SCL_19346495_ChIP-Seq_HPC-7_Human0.88425753
118ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88272119
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88024532
120GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.86632704
121CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86514805
122* SMAD3_21741376_ChIP-Seq_HESCs_Human0.86096365
123SMAD4_21741376_ChIP-Seq_ESCs_Human0.85212217
124RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.85151975
125EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.85127194
126FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84419406
127GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84036180
128SPI1_23127762_ChIP-Seq_K562_Human0.83628936
129SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.82944643
130KLF4_19829295_ChIP-Seq_ESCs_Human0.81605168
131TAF15_26573619_Chip-Seq_HEK293_Human0.81449322
132SMAD4_21741376_ChIP-Seq_HESCs_Human0.81443734
133CTCF_27219007_Chip-Seq_Bcells_Human0.80304851
134P300_19829295_ChIP-Seq_ESCs_Human0.80031937
135* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.79927777
136BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79154029
137* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.76502683
138SMC4_20622854_ChIP-Seq_HELA_Human0.74280027

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.63850017
2* MP0003635_abnormal_synaptic_transmissio4.43724541
3MP0003880_abnormal_central_pattern4.20582275
4MP0002822_catalepsy3.63478133
5MP0009745_abnormal_behavioral_response3.62027729
6MP0009046_muscle_twitch3.59617798
7MP0004270_analgesia3.56848855
8* MP0002063_abnormal_learning/memory/cond3.47538730
9MP0002064_seizures3.29721553
10MP0002572_abnormal_emotion/affect_behav2.82828176
11MP0001968_abnormal_touch/_nociception2.78307838
12MP0002272_abnormal_nervous_system2.57409875
13MP0001486_abnormal_startle_reflex2.56906151
14MP0000569_abnormal_digit_pigmentation2.55082633
15MP0005423_abnormal_somatic_nervous2.53300308
16MP0001501_abnormal_sleep_pattern2.49502868
17MP0002734_abnormal_mechanical_nocicepti2.38247949
18MP0008569_lethality_at_weaning2.31928241
19MP0001440_abnormal_grooming_behavior2.09994015
20MP0004858_abnormal_nervous_system1.98079815
21MP0003329_amyloid_beta_deposits1.97461924
22MP0002736_abnormal_nociception_after1.93025773
23MP0003879_abnormal_hair_cell1.88982676
24MP0002909_abnormal_adrenal_gland1.88405065
25MP0004811_abnormal_neuron_physiology1.88151200
26MP0002733_abnormal_thermal_nociception1.87655272
27MP0002067_abnormal_sensory_capabilities1.87603384
28MP0001970_abnormal_pain_threshold1.83620223
29MP0009780_abnormal_chondrocyte_physiolo1.81732115
30MP0002735_abnormal_chemical_nociception1.79576268
31MP0004924_abnormal_behavior1.72401395
32MP0005386_behavior/neurological_phenoty1.72401395
33MP0004510_myositis1.68729055
34MP0002557_abnormal_social/conspecific_i1.62774838
35MP0002184_abnormal_innervation1.61218528
36MP0003303_peritoneal_inflammation1.52998416
37MP0003633_abnormal_nervous_system1.52604566
38MP0003075_altered_response_to1.51496315
39MP0000955_abnormal_spinal_cord1.41738654
40MP0002066_abnormal_motor_capabilities/c1.37295490
41MP0003123_paternal_imprinting1.37108614
42MP0004885_abnormal_endolymph1.36919584
43MP0001348_abnormal_lacrimal_gland1.36212225
44MP0000778_abnormal_nervous_system1.35656725
45MP0008260_abnormal_autophagy1.30442071
46MP0000604_amyloidosis1.28464393
47MP0003631_nervous_system_phenotype1.27563612
48MP0008961_abnormal_basal_metabolism1.26084459
49MP0005167_abnormal_blood-brain_barrier1.25982676
50MP0003172_abnormal_lysosome_physiology1.23901847
51MP0002882_abnormal_neuron_morphology1.22240340
52MP0003436_decreased_susceptibility_to1.17628001
53MP0008874_decreased_physiological_sensi1.17523077
54MP0003724_increased_susceptibility_to1.16402672
55MP0001984_abnormal_olfaction1.13113769
56MP0003787_abnormal_imprinting1.11960015
57MP0005646_abnormal_pituitary_gland1.11768053
58MP0003690_abnormal_glial_cell1.10651213
59MP0003705_abnormal_hypodermis_morpholog1.09015089
60MP0008872_abnormal_physiological_respon1.03980702
61MP0002152_abnormal_brain_morphology1.03298521
62MP0003183_abnormal_peptide_metabolism1.02938297
63MP0004145_abnormal_muscle_electrophysio1.02376790
64MP0001502_abnormal_circadian_rhythm0.98293602
65MP0003632_abnormal_nervous_system0.96154315
66MP0003191_abnormal_cellular_cholesterol0.95741526
67MP0001177_atelectasis0.90076125
68MP0004742_abnormal_vestibular_system0.89305618
69MP0004142_abnormal_muscle_tone0.85841639
70MP0003045_fibrosis0.85464232
71MP0000751_myopathy0.85181786
72MP0004147_increased_porphyrin_level0.84035559
73MP0000920_abnormal_myelination0.83382441
74MP0001986_abnormal_taste_sensitivity0.83311235
75MP0001188_hyperpigmentation0.80351740
76* MP0002069_abnormal_eating/drinking_beha0.79331521
77MP0003283_abnormal_digestive_organ0.79104256
78MP0002090_abnormal_vision0.77450065
79MP0005623_abnormal_meninges_morphology0.76655389
80MP0003634_abnormal_glial_cell0.75799639
81MP0002229_neurodegeneration0.73564719
82MP0000013_abnormal_adipose_tissue0.72903617
83MP0003122_maternal_imprinting0.72536864
84MP0009278_abnormal_bone_marrow0.72300222
85* MP0005535_abnormal_body_temperature0.71694180
86MP0005166_decreased_susceptibility_to0.71074710
87MP0002419_abnormal_innate_immunity0.70943386
88MP0010234_abnormal_vibrissa_follicle0.67960333
89MP0001851_eye_inflammation0.67363399
90MP0001905_abnormal_dopamine_level0.66953852
91MP0005645_abnormal_hypothalamus_physiol0.66361660
92MP0004085_abnormal_heartbeat0.64991329
93MP0004130_abnormal_muscle_cell0.64611572
94MP0006082_CNS_inflammation0.64414408
95MP0005409_darkened_coat_color0.64162457
96MP0010386_abnormal_urinary_bladder0.64120942
97MP0005388_respiratory_system_phenotype0.63477222
98MP0002133_abnormal_respiratory_system0.63477222
99MP0005025_abnormal_response_to0.63215590
100MP0005000_abnormal_immune_tolerance0.61099570
101MP0001529_abnormal_vocalization0.60808872
102MP0006276_abnormal_autonomic_nervous0.57507208
103MP0005058_abnormal_lysosome_morphology0.57450715
104MP0001346_abnormal_lacrimal_gland0.56409515
105MP0004947_skin_inflammation0.56374275
106MP0001765_abnormal_ion_homeostasis0.52719180
107MP0003300_gastrointestinal_ulcer0.52697731
108MP0010769_abnormal_survival0.52165323
109MP0004484_altered_response_of0.51214077
110MP0002089_abnormal_postnatal_growth/wei0.50518905
111MP0005174_abnormal_tail_pigmentation0.49895076
112MP0010768_mortality/aging0.48912053
113MP0000015_abnormal_ear_pigmentation0.48243305
114MP0001963_abnormal_hearing_physiology0.48210034
115MP0000747_muscle_weakness0.48105929
116MP0003866_abnormal_defecation0.47823869
117MP0001533_abnormal_skeleton_physiology0.47460049
118MP0002082_postnatal_lethality0.47332306
119MP0010770_preweaning_lethality0.47332306
120MP0001485_abnormal_pinna_reflex0.46147735
121* MP0003956_abnormal_body_size0.45137403
122MP0001943_abnormal_respiration0.45049040
123MP0000681_abnormal_thyroid_gland0.42972219
124MP0004233_abnormal_muscle_weight0.42831605
125MP0002873_normal_phenotype0.41954841
126MP0002083_premature_death0.41947580
127MP0005394_taste/olfaction_phenotype0.41330850
128MP0005499_abnormal_olfactory_system0.41330850
129MP0005187_abnormal_penis_morphology0.40642685
130MP0005310_abnormal_salivary_gland0.39146527

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.11436532
2Myokymia (HP:0002411)7.01125426
3Focal seizures (HP:0007359)5.89508415
4Visual hallucinations (HP:0002367)5.47037047
5Action tremor (HP:0002345)4.55919119
6Progressive cerebellar ataxia (HP:0002073)4.29773751
7Epileptic encephalopathy (HP:0200134)4.28451880
8Atonic seizures (HP:0010819)4.25377159
9Febrile seizures (HP:0002373)4.16134171
10Gaze-evoked nystagmus (HP:0000640)3.94060487
11Poor eye contact (HP:0000817)3.87631276
12Absence seizures (HP:0002121)3.85282021
13Papilledema (HP:0001085)3.70399182
14Generalized tonic-clonic seizures (HP:0002069)3.67009134
15Broad-based gait (HP:0002136)3.64784162
16Impaired smooth pursuit (HP:0007772)3.49533976
17Dialeptic seizures (HP:0011146)3.46391935
18Impaired social interactions (HP:0000735)3.45476432
19Abnormal social behavior (HP:0012433)3.45476432
20Supranuclear gaze palsy (HP:0000605)3.40620830
21Dysdiadochokinesis (HP:0002075)3.36384631
22Annular pancreas (HP:0001734)3.31155796
23Ankle clonus (HP:0011448)3.27850477
24Depression (HP:0000716)3.24949431
25Dysmetric saccades (HP:0000641)3.24630459
26Hemiplegia (HP:0002301)3.17955848
27Dysmetria (HP:0001310)3.15796532
28Impaired vibration sensation in the lower limbs (HP:0002166)3.14969770
29Urinary bladder sphincter dysfunction (HP:0002839)3.09167384
30Abnormality of ocular smooth pursuit (HP:0000617)3.08919098
31Truncal ataxia (HP:0002078)3.07980364
32Abnormality of the lower motor neuron (HP:0002366)3.03546506
33Genetic anticipation (HP:0003743)2.99062207
34Scanning speech (HP:0002168)2.97871400
35Postural instability (HP:0002172)2.95293545
36Pointed chin (HP:0000307)2.93169960
37Stereotypic behavior (HP:0000733)2.92664583
38Mutism (HP:0002300)2.91991430
39Diplopia (HP:0000651)2.87382445
40Abnormality of binocular vision (HP:0011514)2.87382445
41Anxiety (HP:0000739)2.82509177
42Intention tremor (HP:0002080)2.80333607
43Torticollis (HP:0000473)2.77274344
44Cerebral hypomyelination (HP:0006808)2.74604206
45Hemiparesis (HP:0001269)2.74189645
46Progressive inability to walk (HP:0002505)2.64187104
47Urinary urgency (HP:0000012)2.62582792
48Status epilepticus (HP:0002133)2.56112345
49Slow saccadic eye movements (HP:0000514)2.55759468
50Amblyopia (HP:0000646)2.55620681
51Rigidity (HP:0002063)2.52295459
52Delusions (HP:0000746)2.51074191
53Focal dystonia (HP:0004373)2.50145804
54Resting tremor (HP:0002322)2.49637446
55Rapidly progressive (HP:0003678)2.48180680
56Abnormal eating behavior (HP:0100738)2.47681138
57Peripheral hypomyelination (HP:0007182)2.46345050
58Lower limb amyotrophy (HP:0007210)2.43455846
59Akinesia (HP:0002304)2.41850970
60Drooling (HP:0002307)2.37420746
61Excessive salivation (HP:0003781)2.37420746
62Inappropriate behavior (HP:0000719)2.36805108
63Bradykinesia (HP:0002067)2.33471620
64Spastic gait (HP:0002064)2.32580302
65Neuronal loss in central nervous system (HP:0002529)2.32279028
66Limb dystonia (HP:0002451)2.29911126
67Lower limb asymmetry (HP:0100559)2.24612296
68Impaired vibratory sensation (HP:0002495)2.24034238
69Insomnia (HP:0100785)2.22817136
70Craniofacial dystonia (HP:0012179)2.20638542
71Cerebral inclusion bodies (HP:0100314)2.20395524
72Absent speech (HP:0001344)2.19090779
73Apathy (HP:0000741)2.18639942
74Abnormality of saccadic eye movements (HP:0000570)2.18241919
75Eczematoid dermatitis (HP:0000976)2.16903690
76Obstructive sleep apnea (HP:0002870)2.16562407
77Abnormality of the periventricular white matter (HP:0002518)2.16486971
78Memory impairment (HP:0002354)2.15985906
79Bundle branch block (HP:0011710)2.15174935
80Ankyloglossia (HP:0010296)2.15048891
81Hyperventilation (HP:0002883)2.12998806
82Sleep apnea (HP:0010535)2.12701138
83Ventricular fibrillation (HP:0001663)2.06529105
84Abnormality of the corticospinal tract (HP:0002492)2.05797756
85Spastic tetraparesis (HP:0001285)2.05781444
86Megalencephaly (HP:0001355)2.02097592
87Amyotrophic lateral sclerosis (HP:0007354)2.01496366
88Upper limb amyotrophy (HP:0009129)2.01289222
89Distal upper limb amyotrophy (HP:0007149)2.01289222
90Ocular albinism (HP:0001107)2.00866641
91Neurofibrillary tangles (HP:0002185)1.99210781
92Amyloidosis (HP:0011034)1.98958234
93Epileptiform EEG discharges (HP:0011182)1.95957581
94Spinal canal stenosis (HP:0003416)1.95849829
95Diminished motivation (HP:0000745)1.95735096
96Clonus (HP:0002169)1.95438907
97Gait ataxia (HP:0002066)1.94331044
98Dementia (HP:0000726)1.93797736
99EEG with generalized epileptiform discharges (HP:0011198)1.91410129
100Inability to walk (HP:0002540)1.91006127
101Lower limb muscle weakness (HP:0007340)1.86139243
102Macroorchidism (HP:0000053)1.85131234
103Incomplete penetrance (HP:0003829)1.84340793
104Hypsarrhythmia (HP:0002521)1.84072948
105Choreoathetosis (HP:0001266)1.83935777
106Protruding tongue (HP:0010808)1.83166394
107Postural tremor (HP:0002174)1.81662601
108Cerebral aneurysm (HP:0004944)1.81467984
109Limb ataxia (HP:0002070)1.81286109
110Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.79356472
111Iris hypopigmentation (HP:0007730)1.79171867
112Psychosis (HP:0000709)1.78485668
113Intellectual disability, profound (HP:0002187)1.76715502
114Insidious onset (HP:0003587)1.76066432
115Termporal pattern (HP:0011008)1.76066432
116Hyperacusis (HP:0010780)1.75406880
117Tetraplegia (HP:0002445)1.75231754
118Absent frontal sinuses (HP:0002688)1.73931496
119Increased cerebral lipofuscin (HP:0011813)1.73695321
120Achilles tendon contracture (HP:0001771)1.73647764
121Decreased motor nerve conduction velocity (HP:0003431)1.71261018
122Distal sensory impairment (HP:0002936)1.69178708
123Cellulitis (HP:0100658)1.68779473
124Onion bulb formation (HP:0003383)1.68719922
125Slow progression (HP:0003677)1.65111071
126Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.64358435
127Hand muscle atrophy (HP:0009130)1.64300773

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.08405267
2NTRK34.03924607
3MAP3K93.97628427
4RIPK43.46510062
5CAMKK12.66479096
6MAP3K42.57663810
7KSR22.46249761
8MINK12.44862794
9PAK62.37111981
10PRKD32.32968879
11SIK22.22197765
12MARK12.10271200
13NTRK21.98677719
14CAMKK21.95204591
15MAP3K131.87433597
16NTRK11.86394823
17MAP2K71.85914768
18RIPK11.84836384
19* DAPK21.79232245
20FES1.73530054
21TYRO31.67676037
22MAP2K41.58581113
23CDK51.58170843
24TAOK11.57568249
25PRPF4B1.51943975
26LATS21.51296921
27KSR11.50534003
28STK381.49608135
29MAP3K111.49166048
30CDK191.24134772
31PLK21.15448833
32TRIB31.13384354
33STK111.13381469
34MAP3K21.12344424
35TNIK1.09457500
36ARAF1.08681016
37CAMK11.08026280
38GRK51.05936041
39ALK1.03959367
40PRKCH1.03559252
41RAF11.01436607
42PRKCG1.01412026
43PTK2B0.99633214
44RET0.99577482
45* DAPK10.98776030
46ERN10.97867799
47PINK10.97345546
48MAP3K120.97069594
49CAMK1G0.93871288
50PDK10.90307445
51MAP2K30.89573983
52UHMK10.87115056
53IRAK20.86929564
54MAPK130.85016052
55JAK20.83812416
56SGK30.83460610
57SGK10.81763321
58PDPK10.81272657
59CDK150.80594430
60NEK60.80041374
61BMPR20.78304577
62CDK180.78222054
63TAOK20.75386816
64CAMK40.74016106
65SMG10.72505342
66SCYL20.71704052
67MARK20.70845780
68SGK20.70825228
69CDK140.70331311
70CDK11A0.69873991
71SGK4940.68786421
72SGK2230.68786421
73TNK20.67711372
74WNK10.67545150
75PNCK0.66490898
76MAP3K10.64202580
77CAMK2A0.62011033
78FYN0.61939833
79FGR0.57575342
80EEF2K0.57265717
81BMX0.56918645
82BRAF0.55740323
83TYK20.52002579
84* RPS6KA30.51314683
85MAP3K70.49654687
86PRKG20.49287372
87BLK0.49150741
88ICK0.48563658
89DYRK1A0.47735213
90PRKCZ0.47473040
91MAP4K10.47311469
92DMPK0.47098798
93OXSR10.46943902
94SYK0.46308727
95CAMK2G0.46251383
96SIK30.45909503
97IRAK40.45348178
98MAPK100.45298626
99PKN20.43354663
100CAMK2B0.41879688
101CCNB10.41844074
102CDC42BPA0.41543493
103MAPK70.40927474
104PHKG10.40516032
105PHKG20.40516032
106MAPK120.38494775
107GRK60.38261280
108ROCK20.36688710
109HIPK20.36414859
110CSNK1G20.36176694
111PDGFRA0.35617034
112RPS6KA20.35000196
113HCK0.34834322
114CAMK1D0.33411584
115JAK10.33395662
116MAP3K60.32232802
117PRKCB0.31833588
118MAP2K10.31751961
119PAK30.31014975
120MAPK80.30565084
121PRKD20.30498047
122SRC0.29258544
123BRSK10.28566982

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.02186950
2Synaptic vesicle cycle_Homo sapiens_hsa047212.81333515
3Olfactory transduction_Homo sapiens_hsa047402.75542241
4Long-term potentiation_Homo sapiens_hsa047202.64476649
5Circadian entrainment_Homo sapiens_hsa047132.53772093
6Glutamatergic synapse_Homo sapiens_hsa047242.49467533
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.36576979
8Morphine addiction_Homo sapiens_hsa050322.36127485
9GABAergic synapse_Homo sapiens_hsa047272.27165255
10Amphetamine addiction_Homo sapiens_hsa050312.19301347
11Salivary secretion_Homo sapiens_hsa049702.12332349
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.02114971
13Dopaminergic synapse_Homo sapiens_hsa047281.97356109
14Aldosterone synthesis and secretion_Homo sapiens_hsa049251.95247590
15Cholinergic synapse_Homo sapiens_hsa047251.89042779
16Gastric acid secretion_Homo sapiens_hsa049711.88435263
17Insulin secretion_Homo sapiens_hsa049111.71442838
18Long-term depression_Homo sapiens_hsa047301.70779690
19* Oxytocin signaling pathway_Homo sapiens_hsa049211.69866592
20Renin secretion_Homo sapiens_hsa049241.67654454
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62822316
22Calcium signaling pathway_Homo sapiens_hsa040201.50776544
23GnRH signaling pathway_Homo sapiens_hsa049121.47523939
24Cocaine addiction_Homo sapiens_hsa050301.45887329
25Taste transduction_Homo sapiens_hsa047421.45013572
26Type II diabetes mellitus_Homo sapiens_hsa049301.44449789
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40898539
28Glioma_Homo sapiens_hsa052141.36439049
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.35540993
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34141161
31cAMP signaling pathway_Homo sapiens_hsa040241.30201527
32Gap junction_Homo sapiens_hsa045401.28328236
33Serotonergic synapse_Homo sapiens_hsa047261.25257745
34Estrogen signaling pathway_Homo sapiens_hsa049151.24354187
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15622786
36cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11305959
37Nitrogen metabolism_Homo sapiens_hsa009101.10455875
38Vitamin B6 metabolism_Homo sapiens_hsa007501.06304059
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05444802
40Phospholipase D signaling pathway_Homo sapiens_hsa040721.05056690
41ErbB signaling pathway_Homo sapiens_hsa040121.02167662
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00671475
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97839149
44Neurotrophin signaling pathway_Homo sapiens_hsa047220.97802417
45VEGF signaling pathway_Homo sapiens_hsa043700.96142707
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94944078
47Prion diseases_Homo sapiens_hsa050200.92929892
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92000014
49Dorso-ventral axis formation_Homo sapiens_hsa043200.91605874
50Melanogenesis_Homo sapiens_hsa049160.91132588
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90532744
52Pancreatic secretion_Homo sapiens_hsa049720.86752083
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.86083063
54Axon guidance_Homo sapiens_hsa043600.84355818
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84253829
56Collecting duct acid secretion_Homo sapiens_hsa049660.83587425
57mTOR signaling pathway_Homo sapiens_hsa041500.81063145
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79985232
59Non-small cell lung cancer_Homo sapiens_hsa052230.78694085
60Oocyte meiosis_Homo sapiens_hsa041140.78226486
61MAPK signaling pathway_Homo sapiens_hsa040100.77963557
62Choline metabolism in cancer_Homo sapiens_hsa052310.76713139
63Chemokine signaling pathway_Homo sapiens_hsa040620.76649460
64Thyroid hormone synthesis_Homo sapiens_hsa049180.76397523
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76001330
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73134204
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.69778118
68Dilated cardiomyopathy_Homo sapiens_hsa054140.68774260
69Rap1 signaling pathway_Homo sapiens_hsa040150.67988598
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67298764
71Inositol phosphate metabolism_Homo sapiens_hsa005620.66718946
72Platelet activation_Homo sapiens_hsa046110.66111411
73Acute myeloid leukemia_Homo sapiens_hsa052210.63390824
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62286487
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62283630
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61051551
77African trypanosomiasis_Homo sapiens_hsa051430.60398497
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60319959
79B cell receptor signaling pathway_Homo sapiens_hsa046620.60231924
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59935522
81Endocytosis_Homo sapiens_hsa041440.59398672
82Leishmaniasis_Homo sapiens_hsa051400.59280838
83HIF-1 signaling pathway_Homo sapiens_hsa040660.55144076
84Endometrial cancer_Homo sapiens_hsa052130.55030078
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54064852
86Osteoclast differentiation_Homo sapiens_hsa043800.53717921
87Ras signaling pathway_Homo sapiens_hsa040140.52504403
88* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50322640
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50071205
90Type I diabetes mellitus_Homo sapiens_hsa049400.49757602
91Glucagon signaling pathway_Homo sapiens_hsa049220.49633047
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49604305
93Fatty acid biosynthesis_Homo sapiens_hsa000610.47400704
94Renal cell carcinoma_Homo sapiens_hsa052110.47072745
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46743041
96Prolactin signaling pathway_Homo sapiens_hsa049170.46576302
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46277431
98Tuberculosis_Homo sapiens_hsa051520.45966681
99Cardiac muscle contraction_Homo sapiens_hsa042600.45335452
100Insulin signaling pathway_Homo sapiens_hsa049100.45116731
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44779062
102T cell receptor signaling pathway_Homo sapiens_hsa046600.43203765
103* Alcoholism_Homo sapiens_hsa050340.41670006
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40772131
105Bile secretion_Homo sapiens_hsa049760.40286810
106Chronic myeloid leukemia_Homo sapiens_hsa052200.38487615
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37988673
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37737677
109Amoebiasis_Homo sapiens_hsa051460.37350888
110Vibrio cholerae infection_Homo sapiens_hsa051100.37313758
111Salmonella infection_Homo sapiens_hsa051320.36469388
112Colorectal cancer_Homo sapiens_hsa052100.36114921

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »