CAMK2N2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is highly similar to the rat CaM-KII inhibitory protein, an inhibitor of calcium/calmodulin-dependent protein kinase II (CAMKII). CAMKII regulates numerous physiological functions, including neuronal synaptic plasticity through the phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate (AMPA) receptors. Studies of the similar protein in rat suggest that this protein may function as a negative regulator of CaM-KII and may act to inhibit the phosphorylation of AMPA receptors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.36470269
2synaptic vesicle maturation (GO:0016188)6.23148081
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.75989035
4locomotory exploration behavior (GO:0035641)5.75770676
5synaptic vesicle exocytosis (GO:0016079)5.53235822
6glutamate secretion (GO:0014047)5.47906038
7vocalization behavior (GO:0071625)5.40883120
8regulation of synaptic vesicle exocytosis (GO:2000300)5.38136185
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.20540453
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.14131356
11neurotransmitter secretion (GO:0007269)4.92256896
12neuronal action potential propagation (GO:0019227)4.83776168
13regulation of glutamate receptor signaling pathway (GO:1900449)4.82053255
14neuron cell-cell adhesion (GO:0007158)4.78416634
15regulation of synaptic vesicle transport (GO:1902803)4.76147781
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.75525104
17layer formation in cerebral cortex (GO:0021819)4.74090234
18protein localization to synapse (GO:0035418)4.66689394
19exploration behavior (GO:0035640)4.48072098
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.40492463
21gamma-aminobutyric acid transport (GO:0015812)4.36700383
22proline transport (GO:0015824)4.22635826
23dendritic spine morphogenesis (GO:0060997)4.18791889
24regulation of neuronal synaptic plasticity (GO:0048168)4.14944106
25neurotransmitter transport (GO:0006836)4.00346483
26cellular potassium ion homeostasis (GO:0030007)3.99832402
27regulation of long-term neuronal synaptic plasticity (GO:0048169)3.99407343
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.93663742
29synaptic transmission, glutamatergic (GO:0035249)3.90917833
30glutamate receptor signaling pathway (GO:0007215)3.86268684
31neuron recognition (GO:0008038)3.83470954
32potassium ion homeostasis (GO:0055075)3.81252257
33activation of protein kinase A activity (GO:0034199)3.80963937
34long-term memory (GO:0007616)3.76716967
35neuronal ion channel clustering (GO:0045161)3.74976391
36neuromuscular process controlling posture (GO:0050884)3.74613252
37behavioral response to nicotine (GO:0035095)3.73851241
38cerebellar Purkinje cell differentiation (GO:0021702)3.73102996
39sodium ion export (GO:0071436)3.71312485
40neurotransmitter-gated ion channel clustering (GO:0072578)3.70621952
41regulation of neurotransmitter levels (GO:0001505)3.70011552
42neuron-neuron synaptic transmission (GO:0007270)3.65267749
43glycine transport (GO:0015816)3.63719950
44pyrimidine nucleobase catabolic process (GO:0006208)3.62108451
45regulation of synapse structural plasticity (GO:0051823)3.61033903
46axon ensheathment in central nervous system (GO:0032291)3.59944504
47central nervous system myelination (GO:0022010)3.59944504
48positive regulation of synaptic transmission, GABAergic (GO:0032230)3.59540758
49establishment of mitochondrion localization (GO:0051654)3.59499989
50postsynaptic membrane organization (GO:0001941)3.59464520
51positive regulation of neurotransmitter transport (GO:0051590)3.54015507
52positive regulation of membrane potential (GO:0045838)3.53731162
53adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.49862527
54regulation of synapse maturation (GO:0090128)3.49059011
55transmission of nerve impulse (GO:0019226)3.47019149
56response to pheromone (GO:0019236)3.45157332
57regulation of vesicle fusion (GO:0031338)3.42707614
58synaptic vesicle endocytosis (GO:0048488)3.42635890
59axonal fasciculation (GO:0007413)3.42294514
60gamma-aminobutyric acid signaling pathway (GO:0007214)3.42034725
61positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.41955457
62establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.41809195
63mitochondrion transport along microtubule (GO:0047497)3.41809195
64regulation of neurotransmitter secretion (GO:0046928)3.41406868
65neuromuscular synaptic transmission (GO:0007274)3.40812044
66regulation of excitatory postsynaptic membrane potential (GO:0060079)3.40638954
67membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.40308124
68cerebellar Purkinje cell layer development (GO:0021680)3.39563304
69cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.37753446
70regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.37171015
71dendrite morphogenesis (GO:0048813)3.34176203
72positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.33336011
73regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.31458992
74regulation of postsynaptic membrane potential (GO:0060078)3.31313403
75neurofilament cytoskeleton organization (GO:0060052)3.28798419
76cell communication by electrical coupling (GO:0010644)3.26579082
77potassium ion import (GO:0010107)3.26084029
78neuromuscular process controlling balance (GO:0050885)3.25582082
79mechanosensory behavior (GO:0007638)3.25067853
80negative regulation of synaptic transmission, GABAergic (GO:0032229)3.21490653
81mating behavior (GO:0007617)3.21421919
82cerebellar granule cell differentiation (GO:0021707)3.19720833
83regulation of synaptic plasticity (GO:0048167)3.19029650
84dopamine receptor signaling pathway (GO:0007212)3.17689358
85positive regulation of dendritic spine morphogenesis (GO:0061003)3.17173446
86positive regulation of synapse maturation (GO:0090129)3.16621423
87regulation of neurotransmitter transport (GO:0051588)3.12529554
88nucleobase catabolic process (GO:0046113)3.12160438
89cell differentiation in hindbrain (GO:0021533)3.11962359
90regulation of dendritic spine morphogenesis (GO:0061001)3.11221216
91prepulse inhibition (GO:0060134)3.11207434
92presynaptic membrane assembly (GO:0097105)3.08239410
93negative regulation of microtubule polymerization (GO:0031115)3.06614084
94negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.06604646
95regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.05093142
96intraspecies interaction between organisms (GO:0051703)3.04868151
97social behavior (GO:0035176)3.04868151
98synapse assembly (GO:0007416)3.04162954
99positive regulation of dendritic spine development (GO:0060999)3.04036862
100cell migration in hindbrain (GO:0021535)3.02686059
101adult walking behavior (GO:0007628)3.02011015
102positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.01781520
103regulation of voltage-gated calcium channel activity (GO:1901385)3.01691221
104long-term synaptic potentiation (GO:0060291)3.01357572
105membrane depolarization during action potential (GO:0086010)3.01332755
106auditory behavior (GO:0031223)3.01112613
107positive regulation of neurotransmitter secretion (GO:0001956)3.01009553
108presynaptic membrane organization (GO:0097090)3.00910574
109regulation of synaptic transmission, glutamatergic (GO:0051966)2.99649297
110response to auditory stimulus (GO:0010996)2.99317057
111membrane repolarization (GO:0086009)2.98690262
112membrane depolarization (GO:0051899)2.97502874
113membrane hyperpolarization (GO:0060081)2.95427688
114axon cargo transport (GO:0008088)2.94591545
115synaptic transmission (GO:0007268)2.93609933
116dendritic spine organization (GO:0097061)2.93107918
117regulation of calcium ion-dependent exocytosis (GO:0017158)2.89879064
118signal release (GO:0023061)2.88895032
119organelle transport along microtubule (GO:0072384)2.88787731
120vesicle transport along microtubule (GO:0047496)2.88475242
121regulation of respiratory system process (GO:0044065)2.88473967
122regulation of synaptic transmission (GO:0050804)2.88165736
123positive regulation of potassium ion transmembrane transport (GO:1901381)2.87878080
124synapse organization (GO:0050808)2.87785584

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.69579453
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.17113736
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15447907
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.10163362
5GBX2_23144817_ChIP-Seq_PC3_Human3.08444433
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.93209822
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.80081249
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.80062761
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.80062761
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.66100321
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.64265183
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.61072339
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.57977446
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.57509855
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57264557
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56132152
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.51245496
18DROSHA_22980978_ChIP-Seq_HELA_Human2.48150055
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.46036595
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.44438955
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.43905949
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.43523843
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.41580200
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.33805160
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.30053394
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.22878371
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.07513447
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.04194832
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.00818149
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.84922904
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.83660357
32AR_21572438_ChIP-Seq_LNCaP_Human1.76401910
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65157153
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60862140
35ZNF274_21170338_ChIP-Seq_K562_Hela1.50670728
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50105712
37RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.47783923
38* RING1B_27294783_Chip-Seq_ESCs_Mouse1.43790663
39SMAD4_21799915_ChIP-Seq_A2780_Human1.42342267
40TAF15_26573619_Chip-Seq_HEK293_Human1.41916129
41ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.40646078
42DNAJC2_21179169_ChIP-ChIP_NT2_Human1.37921063
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37853635
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36160203
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.31646331
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30261109
47ZFP281_18757296_ChIP-ChIP_E14_Mouse1.29592510
48SOX2_21211035_ChIP-Seq_LN229_Gbm1.24056966
49RING1B_27294783_Chip-Seq_NPCs_Mouse1.23720657
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22286374
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21511671
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21245260
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20934080
54* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.20295807
55KDM2B_26808549_Chip-Seq_K562_Human1.19284618
56* AR_19668381_ChIP-Seq_PC3_Human1.17050864
57* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15411505
58SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11877491
59WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10747908
60AR_25329375_ChIP-Seq_VCAP_Human1.09836249
61P300_19829295_ChIP-Seq_ESCs_Human1.08140459
62SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07860655
63RNF2_27304074_Chip-Seq_NSC_Mouse1.07523966
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07092705
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.06790173
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05629759
67GATA1_26923725_Chip-Seq_HPCs_Mouse1.05366498
68* LXR_22292898_ChIP-Seq_THP-1_Human1.05280712
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05277346
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04347083
71STAT3_23295773_ChIP-Seq_U87_Human1.03444398
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03297222
73WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02856729
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02644844
75TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02058555
76SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01542513
77SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01129233
78P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99852023
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99402919
80P68_20966046_ChIP-Seq_HELA_Human0.98970094
81RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98505210
82SMAD_19615063_ChIP-ChIP_OVARY_Human0.97641043
83OCT4_19829295_ChIP-Seq_ESCs_Human0.96985118
84MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96895644
85SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96843306
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96361222
87IGF1R_20145208_ChIP-Seq_DFB_Human0.96288394
88PIAS1_25552417_ChIP-Seq_VCAP_Human0.96223260
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93779219
90YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93389215
91SMC4_20622854_ChIP-Seq_HELA_Human0.93248825
92SMAD3_21741376_ChIP-Seq_ESCs_Human0.93227634
93CTCF_27219007_Chip-Seq_Bcells_Human0.92948828
94OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91763662
95ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91292805
96MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.90656272
97TET1_21490601_ChIP-Seq_MESCs_Mouse0.90049624
98* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.89869407
99TCF4_23295773_ChIP-Seq_U87_Human0.88035135
100* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86304880
101RUNX2_22187159_ChIP-Seq_PCA_Human0.85491381
102TP53_20018659_ChIP-ChIP_R1E_Mouse0.85471779
103CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.84515601
104ARNT_22903824_ChIP-Seq_MCF-7_Human0.84332025
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84148812
106ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84046712
107GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83828088
108SMAD4_21741376_ChIP-Seq_HESCs_Human0.83679939
109CREB1_26743006_Chip-Seq_LNCaP_Human0.83472384
110TET1_21451524_ChIP-Seq_MESCs_Mouse0.81866602
111NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81655278
112DPY_21335234_ChIP-Seq_ESCs_Mouse0.80951090
113AHR_22903824_ChIP-Seq_MCF-7_Human0.80494100
114PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76291436
115KLF4_19829295_ChIP-Seq_ESCs_Human0.75719597
116KDM2B_26808549_Chip-Seq_SUP-B15_Human0.75509598
117POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.75341564
118TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75341564
119AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.75112061
120EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.75041012
121STAT6_21828071_ChIP-Seq_BEAS2B_Human0.74673989
122VDR_22108803_ChIP-Seq_LS180_Human0.74069808
123FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.71970352
124SMAD4_21741376_ChIP-Seq_ESCs_Human0.70406207
125POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.68134849
126SOX3_22085726_ChIP-Seq_NPCs_Mouse0.67157762
127CTCF_20526341_ChIP-Seq_ESCs_Human0.66413871

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.77764578
2MP0003880_abnormal_central_pattern4.81806518
3MP0003635_abnormal_synaptic_transmissio4.03386377
4MP0004270_analgesia3.44311797
5MP0009745_abnormal_behavioral_response3.22236836
6MP0009046_muscle_twitch3.18498305
7MP0002063_abnormal_learning/memory/cond3.14836658
8MP0002064_seizures3.11234379
9MP0005423_abnormal_somatic_nervous3.10366715
10MP0001968_abnormal_touch/_nociception2.95122208
11MP0002572_abnormal_emotion/affect_behav2.76724733
12MP0002734_abnormal_mechanical_nocicepti2.74017091
13MP0002272_abnormal_nervous_system2.57285938
14MP0001486_abnormal_startle_reflex2.47603621
15MP0001440_abnormal_grooming_behavior2.36086356
16MP0001501_abnormal_sleep_pattern2.32295727
17MP0000013_abnormal_adipose_tissue2.30278990
18MP0002733_abnormal_thermal_nociception2.28660461
19MP0006276_abnormal_autonomic_nervous2.17759802
20MP0002735_abnormal_chemical_nociception2.16198792
21MP0002067_abnormal_sensory_capabilities2.11390999
22MP0001970_abnormal_pain_threshold2.08751125
23MP0002736_abnormal_nociception_after2.06988852
24MP0002184_abnormal_innervation1.96609971
25MP0002909_abnormal_adrenal_gland1.95301406
26MP0003122_maternal_imprinting1.92482640
27MP0009780_abnormal_chondrocyte_physiolo1.89701588
28MP0003329_amyloid_beta_deposits1.89319748
29MP0008569_lethality_at_weaning1.85695666
30MP0002557_abnormal_social/conspecific_i1.84819836
31MP0005645_abnormal_hypothalamus_physiol1.82678990
32MP0000778_abnormal_nervous_system1.78460370
33MP0004811_abnormal_neuron_physiology1.75054084
34MP0004858_abnormal_nervous_system1.74565574
35MP0000955_abnormal_spinal_cord1.71906792
36MP0004924_abnormal_behavior1.66280390
37MP0005386_behavior/neurological_phenoty1.66280390
38MP0003879_abnormal_hair_cell1.66044385
39MP0004142_abnormal_muscle_tone1.52999697
40MP0004885_abnormal_endolymph1.51001643
41MP0005646_abnormal_pituitary_gland1.49553377
42MP0002066_abnormal_motor_capabilities/c1.48709119
43MP0002822_catalepsy1.47718293
44MP0002882_abnormal_neuron_morphology1.46926763
45MP0001502_abnormal_circadian_rhythm1.46050011
46MP0003283_abnormal_digestive_organ1.43178018
47MP0003787_abnormal_imprinting1.41299134
48MP0001984_abnormal_olfaction1.40158728
49MP0003633_abnormal_nervous_system1.30810319
50MP0008877_abnormal_DNA_methylation1.26010671
51MP0004742_abnormal_vestibular_system1.20265032
52MP0001905_abnormal_dopamine_level1.17950663
53MP0002152_abnormal_brain_morphology1.13929585
54MP0010386_abnormal_urinary_bladder1.11339745
55MP0004145_abnormal_muscle_electrophysio1.09566539
56MP0002229_neurodegeneration1.08911309
57MP0003631_nervous_system_phenotype1.08820952
58MP0001529_abnormal_vocalization1.08663791
59MP0009379_abnormal_foot_pigmentation1.04164607
60MP0000751_myopathy1.02210423
61MP0008961_abnormal_basal_metabolism0.99643813
62MP0003634_abnormal_glial_cell0.95412255
63MP0002069_abnormal_eating/drinking_beha0.95265224
64MP0001986_abnormal_taste_sensitivity0.95242843
65MP0002638_abnormal_pupillary_reflex0.94994378
66MP0004133_heterotaxia0.93672199
67MP0005551_abnormal_eye_electrophysiolog0.89496187
68MP0005535_abnormal_body_temperature0.89157746
69MP0005394_taste/olfaction_phenotype0.88356301
70MP0005499_abnormal_olfactory_system0.88356301
71MP0001348_abnormal_lacrimal_gland0.88209878
72MP0002837_dystrophic_cardiac_calcinosis0.87540250
73MP0005409_darkened_coat_color0.86689164
74MP0006072_abnormal_retinal_apoptosis0.85083677
75MP0001963_abnormal_hearing_physiology0.83855385
76MP0001485_abnormal_pinna_reflex0.82033455
77MP0000003_abnormal_adipose_tissue0.80987911
78MP0000631_abnormal_neuroendocrine_gland0.80387742
79MP0002752_abnormal_somatic_nervous0.80194723
80MP0000604_amyloidosis0.78917116
81MP0003632_abnormal_nervous_system0.78521669
82MP0000639_abnormal_adrenal_gland0.77870980
83MP0008872_abnormal_physiological_respon0.77659157
84MP0003690_abnormal_glial_cell0.76498373
85MP0002876_abnormal_thyroid_physiology0.76494650
86MP0000569_abnormal_digit_pigmentation0.75598431
87MP0002163_abnormal_gland_morphology0.75565514
88MP0001188_hyperpigmentation0.75060142
89MP0001177_atelectasis0.74741001
90MP0005379_endocrine/exocrine_gland_phen0.73606102
91MP0004085_abnormal_heartbeat0.72137349
92MP0000920_abnormal_myelination0.71362207
93MP0004130_abnormal_muscle_cell0.71151859
94MP0004043_abnormal_pH_regulation0.70009829
95MP0002102_abnormal_ear_morphology0.68212150
96MP0008874_decreased_physiological_sensi0.65964858
97MP0003137_abnormal_impulse_conducting0.65319715
98MP0005187_abnormal_penis_morphology0.64223067
99MP0000026_abnormal_inner_ear0.63995984
100MP0005623_abnormal_meninges_morphology0.63959011
101MP0001944_abnormal_pancreas_morphology0.63394887
102MP0001299_abnormal_eye_distance/0.63380998
103MP0004233_abnormal_muscle_weight0.62624183
104MP0002653_abnormal_ependyma_morphology0.62498166
105MP0001943_abnormal_respiration0.62068031
106MP0003121_genomic_imprinting0.61135750
107MP0003172_abnormal_lysosome_physiology0.59270549
108MP0004215_abnormal_myocardial_fiber0.58765959
109MP0010768_mortality/aging0.58020899
110MP0010769_abnormal_survival0.57822684
111MP0003861_abnormal_nervous_system0.57779998
112MP0002082_postnatal_lethality0.57436988
113MP0010770_preweaning_lethality0.57436988
114MP0003123_paternal_imprinting0.56127293
115MP0001664_abnormal_digestion0.55841808
116MP0003075_altered_response_to0.55781854
117MP0002928_abnormal_bile_duct0.51941431

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.59294133
2Myokymia (HP:0002411)6.17216314
3Visual hallucinations (HP:0002367)5.74481126
4Focal seizures (HP:0007359)5.17255185
5Atonic seizures (HP:0010819)4.80022475
6Progressive cerebellar ataxia (HP:0002073)4.54114804
7Epileptic encephalopathy (HP:0200134)4.36784153
8Febrile seizures (HP:0002373)4.30470596
9Absence seizures (HP:0002121)4.17058749
10Supranuclear gaze palsy (HP:0000605)4.06601683
11Action tremor (HP:0002345)3.80924599
12Generalized tonic-clonic seizures (HP:0002069)3.69289786
13Dialeptic seizures (HP:0011146)3.67244981
14Ankle clonus (HP:0011448)3.47883639
15Poor eye contact (HP:0000817)3.36261166
16Abnormal eating behavior (HP:0100738)3.29828633
17Mutism (HP:0002300)3.21606588
18Papilledema (HP:0001085)3.20571729
19Depression (HP:0000716)3.18173435
20Failure to thrive in infancy (HP:0001531)3.12000705
21Anxiety (HP:0000739)3.09221675
22Abnormal social behavior (HP:0012433)3.06630733
23Impaired social interactions (HP:0000735)3.06630733
24Broad-based gait (HP:0002136)3.06530622
25Limb dystonia (HP:0002451)3.03017363
26Dysdiadochokinesis (HP:0002075)2.94213926
27Agitation (HP:0000713)2.93362238
28Genetic anticipation (HP:0003743)2.88847923
29Progressive inability to walk (HP:0002505)2.85469400
30Impaired vibration sensation in the lower limbs (HP:0002166)2.81431395
31Dysmetria (HP:0001310)2.81004713
32Truncal ataxia (HP:0002078)2.80922599
33Polyphagia (HP:0002591)2.78603954
34Pheochromocytoma (HP:0002666)2.77465646
35Megalencephaly (HP:0001355)2.74975225
36Gaze-evoked nystagmus (HP:0000640)2.71284990
37Amblyopia (HP:0000646)2.71188478
38Postural instability (HP:0002172)2.68662346
39EEG with generalized epileptiform discharges (HP:0011198)2.68522914
40Epileptiform EEG discharges (HP:0011182)2.67093294
41Cerebral hypomyelination (HP:0006808)2.66258686
42Urinary bladder sphincter dysfunction (HP:0002839)2.66011462
43Hemiparesis (HP:0001269)2.65923954
44Abnormality of the lower motor neuron (HP:0002366)2.65262662
45Neurofibrillary tangles (HP:0002185)2.63486284
46Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.61626328
47Cerebral inclusion bodies (HP:0100314)2.60948679
48Hypsarrhythmia (HP:0002521)2.59888928
49Hemiplegia (HP:0002301)2.54566332
50Ventricular fibrillation (HP:0001663)2.51817452
51Torticollis (HP:0000473)2.46642072
52Drooling (HP:0002307)2.46356638
53Excessive salivation (HP:0003781)2.46356638
54Hyperventilation (HP:0002883)2.41204066
55Urinary urgency (HP:0000012)2.39785613
56Abnormality of binocular vision (HP:0011514)2.38869049
57Diplopia (HP:0000651)2.38869049
58Neuroendocrine neoplasm (HP:0100634)2.37762777
59Impaired smooth pursuit (HP:0007772)2.36820716
60Bradykinesia (HP:0002067)2.34801460
61Intention tremor (HP:0002080)2.34796925
62Focal dystonia (HP:0004373)2.30360790
63Spastic gait (HP:0002064)2.29823436
64Scanning speech (HP:0002168)2.29049229
65Stereotypic behavior (HP:0000733)2.28714323
66Status epilepticus (HP:0002133)2.21893817
67Degeneration of the lateral corticospinal tracts (HP:0002314)2.20100096
68Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.20100096
69Fetal akinesia sequence (HP:0001989)2.19916170
70Insidious onset (HP:0003587)2.19085441
71Termporal pattern (HP:0011008)2.19085441
72Amyotrophic lateral sclerosis (HP:0007354)2.18143200
73Spastic tetraplegia (HP:0002510)2.14515770
74Hypoventilation (HP:0002791)2.09857186
75Obstructive sleep apnea (HP:0002870)2.09396263
76Hypercortisolism (HP:0001578)2.08988252
77Insomnia (HP:0100785)2.07526011
78Craniofacial dystonia (HP:0012179)2.06437045
79Abnormality of ocular smooth pursuit (HP:0000617)2.04560168
80Diminished movement (HP:0002374)2.04159999
81Postural tremor (HP:0002174)2.02207953
82Psychosis (HP:0000709)2.02041137
83Abnormality of the corticospinal tract (HP:0002492)1.99234887
84Lower limb muscle weakness (HP:0007340)1.98840581
85Inability to walk (HP:0002540)1.98517588
86Prolonged QT interval (HP:0001657)1.97892635
87Generalized myoclonic seizures (HP:0002123)1.96766778
88Neuronal loss in central nervous system (HP:0002529)1.94395415
89Restlessness (HP:0000711)1.93862048
90Gait ataxia (HP:0002066)1.90162278
91Abnormal EKG (HP:0003115)1.89648628
92Incomplete penetrance (HP:0003829)1.88861679
93Absent speech (HP:0001344)1.88599673
94Menstrual irregularities (HP:0000858)1.88391205
95Clonus (HP:0002169)1.86852981
96Delusions (HP:0000746)1.86451836
97Hyperthyroidism (HP:0000836)1.86119694
98Myotonia (HP:0002486)1.86043887
99Gait imbalance (HP:0002141)1.84863544
100Impaired vibratory sensation (HP:0002495)1.84718576
101Rapidly progressive (HP:0003678)1.84620424
102Akinesia (HP:0002304)1.84528964
103Morphological abnormality of the pyramidal tract (HP:0002062)1.83261746
104Spastic tetraparesis (HP:0001285)1.82344225
105Lower limb asymmetry (HP:0100559)1.79097767
106Apathy (HP:0000741)1.78075206
107Abnormality of calcium-phosphate metabolism (HP:0100530)1.76853975
108Neoplasm of the peripheral nervous system (HP:0100007)1.76362980
109Aplasia/Hypoplasia of the brainstem (HP:0007362)1.75898542
110Hypoplasia of the brainstem (HP:0002365)1.75898542
111CNS hypomyelination (HP:0003429)1.75720529
112Specific learning disability (HP:0001328)1.75673497
113Poor suck (HP:0002033)1.74580409
114Dysmetric saccades (HP:0000641)1.74500211
115Sleep apnea (HP:0010535)1.72966054
116Muscular hypotonia of the trunk (HP:0008936)1.72415896
117Abnormality of saccadic eye movements (HP:0000570)1.71715418
118Rib fusion (HP:0000902)1.71593906
119Annular pancreas (HP:0001734)1.71505545
120Rigidity (HP:0002063)1.71375583
121Retinal dysplasia (HP:0007973)1.71353341
122Lissencephaly (HP:0001339)1.70872574
123Neonatal onset (HP:0003623)1.68346296
124Turricephaly (HP:0000262)1.64421874

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.19116595
2MAP3K93.98176095
3MARK13.81735494
4MAP3K43.09834353
5MINK12.94853511
6EPHA42.71700586
7MAP2K72.50268716
8NTRK22.41775221
9PAK62.40771546
10DAPK22.13158029
11PRKD31.99521237
12NTRK11.99486601
13MAP3K121.99423786
14MAP2K41.99308862
15PNCK1.94585665
16UHMK11.86090722
17KSR21.82260072
18CAMKK11.80362653
19DYRK21.75052662
20GRK51.73482637
21CASK1.66847131
22CDK51.56707891
23CDK191.50175604
24SIK21.43749295
25MAPK131.38083553
26STK381.37891024
27PHKG11.36672573
28PHKG21.36672573
29PINK11.34672543
30PLK21.32624887
31LATS21.30845037
32KSR11.30611568
33TAOK11.27398460
34PRKCG1.27281184
35MAP3K21.20986546
36DAPK11.17910214
37ARAF1.13265175
38CAMKK21.12805940
39TYRO31.12188481
40STK161.04532036
41TNIK1.03161281
42PAK31.00956051
43STK111.00511614
44CDK140.98406727
45CDK150.97535585
46CDK180.97399899
47FES0.95318197
48ALK0.94993988
49CAMK2A0.94238874
50RIPK40.94049633
51PRKCH0.91444322
52PRPF4B0.91011222
53MAP3K110.86960938
54CDK11A0.85841618
55LMTK20.84930452
56SGK2230.84101248
57SGK4940.84101248
58RET0.83442576
59PKN10.83058404
60IRAK20.82086597
61WNK10.80546857
62CAMK10.78479361
63CSNK1G20.77386657
64CAMK2B0.76364051
65TNK20.75521118
66CDC42BPA0.74437308
67MARK20.73010154
68OXSR10.71215107
69CAMK1G0.70870903
70MAPKAPK50.67697776
71LIMK10.66677774
72MAPK120.66538923
73BRAF0.66050142
74SCYL20.66037398
75DYRK1A0.65993400
76DYRK1B0.65236908
77MAP3K10.60224601
78CAMK1D0.59584684
79WNK30.59507545
80CAMK2G0.57953844
81PRKCI0.56964838
82RIPK10.56359664
83PRKCZ0.56221003
84SGK20.55981360
85CAMK2D0.55792383
86SGK10.55249324
87MAP3K130.52831848
88SGK30.52698800
89PDPK10.52539218
90MAP2K60.51656775
91BRSK10.50966777
92PDK10.49971755
93CAMK40.48354928
94RPS6KA30.47488544
95PRKCE0.47484174
96CSNK1E0.47371062
97MAPK100.44871783
98RAF10.44540776
99PRKG10.44256370
100MAPK150.43943208
101EPHB20.42885828
102PRKACA0.42004439
103RPS6KA20.41145142
104HIPK20.38995075
105MAP3K60.38603709
106ERBB30.38080714
107FYN0.37902862
108PRKAA10.37897206
109FER0.37627240
110WNK40.37147136
111ROCK20.36359450
112MAPK80.35025717
113TESK10.34860241
114ABL20.34200967
115CSNK1A10.33668312
116NEK60.33402238
117CSNK1G30.32485374
118DAPK30.31535788
119CCNB10.29801848
120DDR20.28864552
121ICK0.28652259
122PRKCB0.28557017

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.65972406
2Synaptic vesicle cycle_Homo sapiens_hsa047213.60940865
3GABAergic synapse_Homo sapiens_hsa047272.81863330
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.55066492
5Long-term potentiation_Homo sapiens_hsa047202.47287350
6Circadian entrainment_Homo sapiens_hsa047132.45937184
7Glutamatergic synapse_Homo sapiens_hsa047242.43063450
8Olfactory transduction_Homo sapiens_hsa047402.40890298
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.39999419
10Morphine addiction_Homo sapiens_hsa050322.35127888
11Amphetamine addiction_Homo sapiens_hsa050312.28294480
12Insulin secretion_Homo sapiens_hsa049112.23820923
13Dopaminergic synapse_Homo sapiens_hsa047282.11185707
14Salivary secretion_Homo sapiens_hsa049701.97253233
15Taste transduction_Homo sapiens_hsa047421.89302766
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.88234825
17Cholinergic synapse_Homo sapiens_hsa047251.86040031
18Gastric acid secretion_Homo sapiens_hsa049711.84358853
19Long-term depression_Homo sapiens_hsa047301.74101320
20Cocaine addiction_Homo sapiens_hsa050301.73485804
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71963817
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68871364
23Serotonergic synapse_Homo sapiens_hsa047261.58614279
24Collecting duct acid secretion_Homo sapiens_hsa049661.58333456
25Oxytocin signaling pathway_Homo sapiens_hsa049211.50927452
26Renin secretion_Homo sapiens_hsa049241.45643719
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.39572794
28GnRH signaling pathway_Homo sapiens_hsa049121.39438196
29Gap junction_Homo sapiens_hsa045401.38049495
30Type II diabetes mellitus_Homo sapiens_hsa049301.34281137
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30250620
32Calcium signaling pathway_Homo sapiens_hsa040201.29398908
33Estrogen signaling pathway_Homo sapiens_hsa049151.28506367
34Cardiac muscle contraction_Homo sapiens_hsa042601.24686331
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24511806
36Vibrio cholerae infection_Homo sapiens_hsa051101.17022042
37cAMP signaling pathway_Homo sapiens_hsa040241.16362471
38Axon guidance_Homo sapiens_hsa043601.14177826
39Glioma_Homo sapiens_hsa052141.09389923
40Nitrogen metabolism_Homo sapiens_hsa009101.06407031
41Melanogenesis_Homo sapiens_hsa049161.06294095
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05023290
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02865576
44Vitamin B6 metabolism_Homo sapiens_hsa007501.02420299
45ErbB signaling pathway_Homo sapiens_hsa040121.00811913
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94683884
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89545997
48Dorso-ventral axis formation_Homo sapiens_hsa043200.86222894
49Oocyte meiosis_Homo sapiens_hsa041140.85145446
50Pancreatic secretion_Homo sapiens_hsa049720.84787568
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82413731
52Thyroid hormone synthesis_Homo sapiens_hsa049180.81137482
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79882643
54Type I diabetes mellitus_Homo sapiens_hsa049400.79540340
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.78757107
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78662865
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.77666673
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74915968
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72873707
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71099588
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68660084
62Choline metabolism in cancer_Homo sapiens_hsa052310.68318890
63Alzheimers disease_Homo sapiens_hsa050100.68067432
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67768626
65MAPK signaling pathway_Homo sapiens_hsa040100.67020859
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.66436363
67Oxidative phosphorylation_Homo sapiens_hsa001900.64576090
68Dilated cardiomyopathy_Homo sapiens_hsa054140.64490581
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63497582
70Prion diseases_Homo sapiens_hsa050200.61707507
71Glucagon signaling pathway_Homo sapiens_hsa049220.59574547
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59474177
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59242769
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57345289
75VEGF signaling pathway_Homo sapiens_hsa043700.57161178
76Phototransduction_Homo sapiens_hsa047440.56376667
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55945465
78Renal cell carcinoma_Homo sapiens_hsa052110.55422054
79Bile secretion_Homo sapiens_hsa049760.52684303
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.52225867
81Ras signaling pathway_Homo sapiens_hsa040140.51838338
82Alcoholism_Homo sapiens_hsa050340.51835436
83Inositol phosphate metabolism_Homo sapiens_hsa005620.51248438
84Insulin signaling pathway_Homo sapiens_hsa049100.50839529
85mTOR signaling pathway_Homo sapiens_hsa041500.50494714
86Parkinsons disease_Homo sapiens_hsa050120.50317301
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49285936
88Endometrial cancer_Homo sapiens_hsa052130.48885507
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47531936
90Hippo signaling pathway_Homo sapiens_hsa043900.46102166
91Endocytosis_Homo sapiens_hsa041440.46065127
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45622742
93Circadian rhythm_Homo sapiens_hsa047100.45591091
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43913033
95Rap1 signaling pathway_Homo sapiens_hsa040150.43554186
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41796015
97Wnt signaling pathway_Homo sapiens_hsa043100.38125796
98Butanoate metabolism_Homo sapiens_hsa006500.36702197
99Non-small cell lung cancer_Homo sapiens_hsa052230.36380735
100Hedgehog signaling pathway_Homo sapiens_hsa043400.35270680
101Huntingtons disease_Homo sapiens_hsa050160.34056498
102Ovarian steroidogenesis_Homo sapiens_hsa049130.33634592
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32859790
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31891642
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30578565
106Prolactin signaling pathway_Homo sapiens_hsa049170.30546969
107AMPK signaling pathway_Homo sapiens_hsa041520.29970199
108Maturity onset diabetes of the young_Homo sapiens_hsa049500.29818798
109Ether lipid metabolism_Homo sapiens_hsa005650.28218029
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.25352767
111Mineral absorption_Homo sapiens_hsa049780.23848731
112Tight junction_Homo sapiens_hsa045300.22641738
113Arginine and proline metabolism_Homo sapiens_hsa003300.22458997
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.20875552

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