CAMK1G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein similar to calcium/calmodulin dependent protein kinase, however, its exact function is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.67692965
2cellular potassium ion homeostasis (GO:0030007)5.54245481
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.25860716
4vocalization behavior (GO:0071625)5.22199908
5synaptic vesicle exocytosis (GO:0016079)5.12807456
6neuron cell-cell adhesion (GO:0007158)5.11446828
7glutamate secretion (GO:0014047)5.08970321
8sodium ion export (GO:0071436)4.97964979
9regulation of synaptic vesicle exocytosis (GO:2000300)4.96676581
10regulation of glutamate receptor signaling pathway (GO:1900449)4.95819625
11regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.92426625
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.87800019
13L-amino acid import (GO:0043092)4.79800229
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.78879946
15synaptic vesicle maturation (GO:0016188)4.72133290
16protein localization to synapse (GO:0035418)4.71461023
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.70089195
18regulation of synaptic vesicle transport (GO:1902803)4.45623483
19neurotransmitter secretion (GO:0007269)4.36215774
20presynaptic membrane assembly (GO:0097105)4.27847716
21postsynaptic membrane organization (GO:0001941)4.26910031
22negative regulation of synaptic transmission, GABAergic (GO:0032229)4.25514005
23locomotory exploration behavior (GO:0035641)4.21523955
24neuronal action potential propagation (GO:0019227)4.16792713
25amino acid import (GO:0043090)4.12329054
26ionotropic glutamate receptor signaling pathway (GO:0035235)4.12321231
27neuron-neuron synaptic transmission (GO:0007270)4.10483348
28neurotransmitter-gated ion channel clustering (GO:0072578)4.09185845
29presynaptic membrane organization (GO:0097090)4.00365653
30synaptic transmission, glutamatergic (GO:0035249)3.97193336
31regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.94117533
32regulation of voltage-gated calcium channel activity (GO:1901385)3.90931492
33neuronal ion channel clustering (GO:0045161)3.88342776
34positive regulation of dendritic spine development (GO:0060999)3.85465249
35positive regulation of synaptic transmission, GABAergic (GO:0032230)3.82636133
36exploration behavior (GO:0035640)3.81993239
37neuromuscular process controlling balance (GO:0050885)3.74744955
38cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.70678294
39glutamate receptor signaling pathway (GO:0007215)3.68443311
40regulation of neuronal synaptic plasticity (GO:0048168)3.64289772
41potassium ion homeostasis (GO:0055075)3.64075176
42neuron recognition (GO:0008038)3.62170213
43proline transport (GO:0015824)3.56525751
44regulation of long-term neuronal synaptic plasticity (GO:0048169)3.53066252
45regulation of dendritic spine morphogenesis (GO:0061001)3.51825240
46acidic amino acid transport (GO:0015800)3.47572801
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.46935056
48neurotransmitter transport (GO:0006836)3.46747178
49regulation of excitatory postsynaptic membrane potential (GO:0060079)3.43884059
50dendritic spine organization (GO:0097061)3.43342113
51startle response (GO:0001964)3.43328528
52regulation of synapse structural plasticity (GO:0051823)3.43247680
53potassium ion import (GO:0010107)3.41013689
54gamma-aminobutyric acid transport (GO:0015812)3.38231385
55regulation of postsynaptic membrane potential (GO:0060078)3.38190467
56gamma-aminobutyric acid signaling pathway (GO:0007214)3.36892086
57regulation of dendritic spine development (GO:0060998)3.36651922
58central nervous system myelination (GO:0022010)3.34795059
59axon ensheathment in central nervous system (GO:0032291)3.34795059
60regulation of synapse maturation (GO:0090128)3.34732172
61establishment of synaptic vesicle localization (GO:0097480)3.34665655
62synaptic vesicle transport (GO:0048489)3.34665655
63response to histamine (GO:0034776)3.31926812
64neurotransmitter uptake (GO:0001504)3.31506989
65layer formation in cerebral cortex (GO:0021819)3.30943677
66pyrimidine nucleobase catabolic process (GO:0006208)3.30463582
67positive regulation of dendritic spine morphogenesis (GO:0061003)3.30035996
68negative regulation of dendrite morphogenesis (GO:0050774)3.27853074
69positive regulation of membrane potential (GO:0045838)3.27304520
70membrane depolarization during action potential (GO:0086010)3.27259819
71positive regulation of neurotransmitter transport (GO:0051590)3.26990839
72regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.26957087
73long-term memory (GO:0007616)3.26234485
74positive regulation of synapse assembly (GO:0051965)3.25103942
75positive regulation of synapse maturation (GO:0090129)3.25089379
76neuromuscular synaptic transmission (GO:0007274)3.24682148
77regulation of ARF protein signal transduction (GO:0032012)3.24665379
78cell communication by electrical coupling (GO:0010644)3.24330611
79regulation of synaptic transmission (GO:0050804)3.24316670
80ATP hydrolysis coupled proton transport (GO:0015991)3.22763827
81energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.22763827
82chemosensory behavior (GO:0007635)3.22341482
83axonal fasciculation (GO:0007413)3.22025609
84regulation of synaptic transmission, GABAergic (GO:0032228)3.21827547
85regulation of neurotransmitter levels (GO:0001505)3.20363022
86regulation of neurotransmitter secretion (GO:0046928)3.20161479
87cell migration in hindbrain (GO:0021535)3.18288915
88regulation of synaptic transmission, glutamatergic (GO:0051966)3.17870019
89long-term synaptic potentiation (GO:0060291)3.17550431
90positive regulation of neurotransmitter secretion (GO:0001956)3.13311390
91cellular sodium ion homeostasis (GO:0006883)3.12838784
92regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.12173449
93L-glutamate transport (GO:0015813)3.11617658
94positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.10891246
95synapse assembly (GO:0007416)3.10559257
96transferrin transport (GO:0033572)3.10283736
97transmission of nerve impulse (GO:0019226)3.09889313
98negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.08862959
99synaptic vesicle endocytosis (GO:0048488)3.08809108
100regulation of neurotransmitter transport (GO:0051588)3.08654201
101vesicle docking involved in exocytosis (GO:0006904)3.07854957
102dendritic spine morphogenesis (GO:0060997)3.07240328
103activation of protein kinase A activity (GO:0034199)3.05782885
104negative regulation of dendrite development (GO:2000171)3.05159027
105regulation of synaptic plasticity (GO:0048167)3.04984091
106regulation of glutamate secretion (GO:0014048)3.03349478
107regulation of vesicle fusion (GO:0031338)3.03163401
108regulation of respiratory system process (GO:0044065)3.03102227
109behavioral response to cocaine (GO:0048148)3.02748098
110response to amphetamine (GO:0001975)3.02418681
111positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.01861830
112neuromuscular process (GO:0050905)3.01807775
113negative regulation of microtubule polymerization (GO:0031115)3.01790220
114G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.01751909
115auditory behavior (GO:0031223)3.01357950
116neuromuscular process controlling posture (GO:0050884)2.98481767
117membrane hyperpolarization (GO:0060081)2.97622138
118adult walking behavior (GO:0007628)2.97137423
119synaptic transmission (GO:0007268)2.95563158
120adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.95148160
121behavioral defense response (GO:0002209)2.94186028
122behavioral fear response (GO:0001662)2.94186028
123response to auditory stimulus (GO:0010996)2.93082842
124cerebellar Purkinje cell differentiation (GO:0021702)2.91289190
125innervation (GO:0060384)2.90491649
126mechanosensory behavior (GO:0007638)2.89198568
127membrane depolarization (GO:0051899)2.89111493
128cerebellar granule cell differentiation (GO:0021707)2.88967903
129detection of calcium ion (GO:0005513)2.88574691
130trivalent inorganic cation transport (GO:0072512)2.88304562
131ferric iron transport (GO:0015682)2.88304562
132regulation of cAMP-dependent protein kinase activity (GO:2000479)2.88160729
133synaptic transmission, dopaminergic (GO:0001963)2.87638378
134positive regulation of synaptic transmission (GO:0050806)2.85249254

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.93289977
2GBX2_23144817_ChIP-Seq_PC3_Human4.15732511
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.24634447
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01064049
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.99470052
6REST_21632747_ChIP-Seq_MESCs_Mouse2.77021715
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.74009634
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.73171913
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.71120551
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.67287620
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.62701537
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.62701537
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62437759
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.59962050
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.57007057
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.46251250
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.42665733
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.40901898
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36758251
20* RARB_27405468_Chip-Seq_BRAIN_Mouse2.32690973
21* REST_18959480_ChIP-ChIP_MESCs_Mouse2.29780226
22* TAF15_26573619_Chip-Seq_HEK293_Human2.24121642
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24044880
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20183012
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.16457960
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.12769912
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.99120315
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93308863
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.89012180
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88793194
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.86644786
32* DROSHA_22980978_ChIP-Seq_HELA_Human1.82879322
33SMAD4_21799915_ChIP-Seq_A2780_Human1.77961631
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73702635
35P300_19829295_ChIP-Seq_ESCs_Human1.70835385
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.66186659
37* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65203086
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61697544
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.59551012
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59257652
41ZNF274_21170338_ChIP-Seq_K562_Hela1.57896266
42RNF2_27304074_Chip-Seq_NSC_Mouse1.49490036
43VDR_22108803_ChIP-Seq_LS180_Human1.45991416
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.42370731
45* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42116188
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.41552722
47ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41032927
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40347478
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39394562
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39281301
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36740442
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35866299
53* SMAD3_21741376_ChIP-Seq_EPCs_Human1.34389030
54AR_21572438_ChIP-Seq_LNCaP_Human1.33365573
55* SOX2_21211035_ChIP-Seq_LN229_Gbm1.31487373
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28722016
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.27042868
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26879382
59KDM2B_26808549_Chip-Seq_K562_Human1.24241633
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24217835
61RING1B_27294783_Chip-Seq_ESCs_Mouse1.23985277
62AR_25329375_ChIP-Seq_VCAP_Human1.23379487
63TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21005634
64FUS_26573619_Chip-Seq_HEK293_Human1.19126986
65STAT3_23295773_ChIP-Seq_U87_Human1.18033823
66RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16706702
67TET1_21490601_ChIP-Seq_MESCs_Mouse1.15564834
68ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13166484
69GATA1_26923725_Chip-Seq_HPCs_Mouse1.11232535
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10939042
71MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10521763
72IGF1R_20145208_ChIP-Seq_DFB_Human1.10378049
73* AR_19668381_ChIP-Seq_PC3_Human1.10275711
74JUN_21703547_ChIP-Seq_K562_Human1.09548678
75P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07816014
76DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07681957
77EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07208822
78CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05832475
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05665290
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.05638591
81RUNX2_22187159_ChIP-Seq_PCA_Human1.05063965
82AHR_22903824_ChIP-Seq_MCF-7_Human1.04376770
83TCF4_23295773_ChIP-Seq_U87_Human1.04217726
84SMAD_19615063_ChIP-ChIP_OVARY_Human1.04063326
85TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04051315
86RING1B_27294783_Chip-Seq_NPCs_Mouse1.03910098
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02656774
88PRDM14_20953172_ChIP-Seq_ESCs_Human1.00896243
89ER_23166858_ChIP-Seq_MCF-7_Human0.99911009
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99535904
91SMAD3_21741376_ChIP-Seq_ESCs_Human0.99169808
92* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98553651
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97640822
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97640822
95* CTCF_27219007_Chip-Seq_Bcells_Human0.97173102
96TP53_20018659_ChIP-ChIP_R1E_Mouse0.96657754
97SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96127418
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96115582
99* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95402971
100SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95258973
101ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94585902
102CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94524881
103* NANOG_18555785_Chip-Seq_ESCs_Mouse0.94458648
104PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93521551
105* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92863129
106WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92330081
107RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91903362
108SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91382063
109SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90626549
110RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88544004
111* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88345227
112SOX9_26525672_Chip-Seq_HEART_Mouse0.88042677
113MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87506517
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87052779
115SMAD4_21741376_ChIP-Seq_HESCs_Human0.85862222
116TP53_18474530_ChIP-ChIP_U2OS_Human0.85704307
117ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84048005
118LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80324605
119DPY_21335234_ChIP-Seq_ESCs_Mouse0.80023224
120OCT4_19829295_ChIP-Seq_ESCs_Human0.78424106
121PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76553707
122ESR2_21235772_ChIP-Seq_MCF-7_Human0.75528257
123KDM2B_26808549_Chip-Seq_REH_Human0.75250219
124EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.72736394

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.07735997
2MP0003880_abnormal_central_pattern4.73903080
3MP0003635_abnormal_synaptic_transmissio3.71979332
4MP0001968_abnormal_touch/_nociception3.45261927
5MP0004270_analgesia3.40557114
6MP0009745_abnormal_behavioral_response3.18933274
7MP0002063_abnormal_learning/memory/cond3.12211214
8MP0002735_abnormal_chemical_nociception3.05164379
9MP0002736_abnormal_nociception_after3.00247905
10MP0009046_muscle_twitch2.93801126
11MP0002064_seizures2.93044202
12MP0002572_abnormal_emotion/affect_behav2.77061969
13MP0002734_abnormal_mechanical_nocicepti2.70954456
14MP0006276_abnormal_autonomic_nervous2.51288465
15MP0002822_catalepsy2.50192023
16MP0002272_abnormal_nervous_system2.46583733
17MP0003122_maternal_imprinting2.40095206
18MP0005423_abnormal_somatic_nervous2.39517310
19MP0001486_abnormal_startle_reflex2.22918175
20MP0001501_abnormal_sleep_pattern2.22768468
21MP0002733_abnormal_thermal_nociception2.19362626
22MP0001529_abnormal_vocalization2.18054328
23MP0001440_abnormal_grooming_behavior2.10254406
24MP0005646_abnormal_pituitary_gland2.09224616
25MP0001970_abnormal_pain_threshold2.06250077
26MP0002184_abnormal_innervation2.00176877
27MP0002067_abnormal_sensory_capabilities1.98364025
28MP0009780_abnormal_chondrocyte_physiolo1.90975694
29MP0003787_abnormal_imprinting1.89723524
30MP0000778_abnormal_nervous_system1.88663064
31MP0002557_abnormal_social/conspecific_i1.82156970
32MP0005645_abnormal_hypothalamus_physiol1.78923819
33MP0003690_abnormal_glial_cell1.74369906
34MP0004924_abnormal_behavior1.72368982
35MP0005386_behavior/neurological_phenoty1.72368982
36MP0004811_abnormal_neuron_physiology1.67118766
37MP0004858_abnormal_nervous_system1.62904819
38MP0000920_abnormal_myelination1.58439253
39MP0001984_abnormal_olfaction1.58256039
40MP0001905_abnormal_dopamine_level1.54187097
41MP0010386_abnormal_urinary_bladder1.54162866
42MP0002909_abnormal_adrenal_gland1.50799451
43MP0000955_abnormal_spinal_cord1.43304898
44MP0002837_dystrophic_cardiac_calcinosis1.43301020
45MP0004147_increased_porphyrin_level1.42229042
46MP0008569_lethality_at_weaning1.41981182
47MP0003879_abnormal_hair_cell1.40721145
48MP0001188_hyperpigmentation1.37398593
49* MP0002882_abnormal_neuron_morphology1.32962448
50MP0002066_abnormal_motor_capabilities/c1.31331155
51MP0000013_abnormal_adipose_tissue1.28396418
52MP0000604_amyloidosis1.28103846
53MP0003329_amyloid_beta_deposits1.26876001
54MP0004233_abnormal_muscle_weight1.26773589
55MP0001502_abnormal_circadian_rhythm1.24722354
56MP0004142_abnormal_muscle_tone1.18840101
57MP0003121_genomic_imprinting1.07449412
58MP0005499_abnormal_olfactory_system1.07148902
59MP0005394_taste/olfaction_phenotype1.07148902
60MP0002876_abnormal_thyroid_physiology1.06680501
61MP0002152_abnormal_brain_morphology1.03769137
62MP0003172_abnormal_lysosome_physiology1.01812418
63MP0003075_altered_response_to0.99848953
64MP0000751_myopathy0.98373695
65MP0000631_abnormal_neuroendocrine_gland0.98153179
66MP0002069_abnormal_eating/drinking_beha0.96745096
67MP0003633_abnormal_nervous_system0.93614137
68MP0004085_abnormal_heartbeat0.91270933
69MP0005167_abnormal_blood-brain_barrier0.90546389
70MP0003632_abnormal_nervous_system0.87443172
71MP0008872_abnormal_physiological_respon0.86453863
72MP0002638_abnormal_pupillary_reflex0.85552565
73MP0004510_myositis0.85410497
74MP0004885_abnormal_endolymph0.85375697
75MP0005551_abnormal_eye_electrophysiolog0.84105838
76MP0003183_abnormal_peptide_metabolism0.82694632
77MP0001963_abnormal_hearing_physiology0.81626838
78MP0002229_neurodegeneration0.81326700
79MP0005535_abnormal_body_temperature0.79788100
80MP0003631_nervous_system_phenotype0.79665769
81MP0002751_abnormal_autonomic_nervous0.79473156
82MP0004043_abnormal_pH_regulation0.79186432
83MP0002752_abnormal_somatic_nervous0.77346465
84MP0001346_abnormal_lacrimal_gland0.77288587
85MP0004742_abnormal_vestibular_system0.77187699
86MP0003123_paternal_imprinting0.76519743
87MP0001986_abnormal_taste_sensitivity0.73137757
88MP0002090_abnormal_vision0.72151399
89MP0001299_abnormal_eye_distance/0.70059437
90MP0003303_peritoneal_inflammation0.68324652
91MP0001177_atelectasis0.66368579
92MP0001664_abnormal_digestion0.66164383
93MP0000538_abnormal_urinary_bladder0.65555528
94MP0004215_abnormal_myocardial_fiber0.64364823
95MP0002653_abnormal_ependyma_morphology0.62696479
96MP0006072_abnormal_retinal_apoptosis0.62126334
97MP0001943_abnormal_respiration0.61310675
98MP0008874_decreased_physiological_sensi0.60224386
99MP0000569_abnormal_digit_pigmentation0.59929516
100MP0003385_abnormal_body_wall0.58538053
101MP0003861_abnormal_nervous_system0.58404058
102MP0000026_abnormal_inner_ear0.56932039
103MP0003938_abnormal_ear_development0.55083523
104MP0004145_abnormal_muscle_electrophysio0.54789946
105MP0005623_abnormal_meninges_morphology0.54723957
106MP0005166_decreased_susceptibility_to0.53774589
107MP0008789_abnormal_olfactory_epithelium0.53758344
108MP0003634_abnormal_glial_cell0.53667556
109MP0010770_preweaning_lethality0.53618985
110MP0002082_postnatal_lethality0.53618985
111MP0003646_muscle_fatigue0.53124278
112MP0003137_abnormal_impulse_conducting0.51640005
113MP0008877_abnormal_DNA_methylation0.51204157
114MP0001485_abnormal_pinna_reflex0.50882526
115MP0004484_altered_response_of0.50850931
116MP0010769_abnormal_survival0.50685054
117MP0000639_abnormal_adrenal_gland0.49179757
118MP0005187_abnormal_penis_morphology0.47095412
119MP0005171_absent_coat_pigmentation0.46470427
120MP0005253_abnormal_eye_physiology0.45508794
121MP0002295_abnormal_pulmonary_circulatio0.45224253
122MP0003956_abnormal_body_size0.43481419

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.55597916
2Myokymia (HP:0002411)5.85807605
3Epileptic encephalopathy (HP:0200134)5.23855709
4Atonic seizures (HP:0010819)5.15088765
5Focal seizures (HP:0007359)5.01709755
6Febrile seizures (HP:0002373)4.48872635
7Neurofibrillary tangles (HP:0002185)4.23367712
8Visual hallucinations (HP:0002367)4.10048414
9Absence seizures (HP:0002121)3.92123593
10Hyperventilation (HP:0002883)3.85999906
11Failure to thrive in infancy (HP:0001531)3.83950681
12Progressive cerebellar ataxia (HP:0002073)3.83887301
13Abnormal hair whorl (HP:0010721)3.70826378
14Dialeptic seizures (HP:0011146)3.56032764
15Generalized tonic-clonic seizures (HP:0002069)3.43985187
16Broad-based gait (HP:0002136)3.30375985
17Papilledema (HP:0001085)3.20665499
18Delusions (HP:0000746)3.20353837
19Limb dystonia (HP:0002451)3.20023154
20Polyphagia (HP:0002591)3.19607899
21Cerebral inclusion bodies (HP:0100314)3.14701494
22Neuronal loss in central nervous system (HP:0002529)3.11711391
23Abnormal eating behavior (HP:0100738)3.09994351
24Cerebral hypomyelination (HP:0006808)3.09256813
25Annular pancreas (HP:0001734)3.06661995
26Intention tremor (HP:0002080)3.03558888
27Amblyopia (HP:0000646)3.03465772
28Pheochromocytoma (HP:0002666)3.03158596
29Poor eye contact (HP:0000817)2.96423344
30Hemiplegia (HP:0002301)2.96199762
31Progressive inability to walk (HP:0002505)2.93002505
32Epileptiform EEG discharges (HP:0011182)2.91728237
33Tetraplegia (HP:0002445)2.90780182
34Apathy (HP:0000741)2.85641699
35Peripheral hypomyelination (HP:0007182)2.83761099
36Protruding tongue (HP:0010808)2.81945880
37EEG with generalized epileptiform discharges (HP:0011198)2.74889646
38Truncal ataxia (HP:0002078)2.72845694
39Neuroendocrine neoplasm (HP:0100634)2.72453610
40Supranuclear gaze palsy (HP:0000605)2.72091252
41Ankle clonus (HP:0011448)2.68798930
42Anxiety (HP:0000739)2.68669941
43Gait imbalance (HP:0002141)2.68325784
44Hypsarrhythmia (HP:0002521)2.67840343
45Diminished motivation (HP:0000745)2.66391270
46Depression (HP:0000716)2.62447153
47Drooling (HP:0002307)2.60982092
48Excessive salivation (HP:0003781)2.60982092
49Gaze-evoked nystagmus (HP:0000640)2.60005078
50Inability to walk (HP:0002540)2.54556598
51Impaired social interactions (HP:0000735)2.54516146
52Abnormal social behavior (HP:0012433)2.54516146
53Impaired vibration sensation in the lower limbs (HP:0002166)2.52221755
54Action tremor (HP:0002345)2.49319841
55Dysdiadochokinesis (HP:0002075)2.41015616
56Choreoathetosis (HP:0001266)2.40151353
57Spastic tetraparesis (HP:0001285)2.38925142
58Hypoplasia of the brainstem (HP:0002365)2.37704401
59Aplasia/Hypoplasia of the brainstem (HP:0007362)2.37704401
60Poor suck (HP:0002033)2.34230473
61Acute necrotizing encephalopathy (HP:0006965)2.32821875
62Split foot (HP:0001839)2.30730315
63Insidious onset (HP:0003587)2.29380259
64Termporal pattern (HP:0011008)2.29380259
65Clonus (HP:0002169)2.28546982
66Obstructive sleep apnea (HP:0002870)2.26363751
67Specific learning disability (HP:0001328)2.26340752
68Progressive macrocephaly (HP:0004481)2.26334055
69Abnormality of the labia minora (HP:0012880)2.25603234
70Rigidity (HP:0002063)2.23990948
71Congenital primary aphakia (HP:0007707)2.23260959
72Abnormal mitochondria in muscle tissue (HP:0008316)2.22612271
73Absent speech (HP:0001344)2.21987136
74Medial flaring of the eyebrow (HP:0010747)2.21311224
75Impaired smooth pursuit (HP:0007772)2.20237423
76Sleep apnea (HP:0010535)2.19713394
77Urinary bladder sphincter dysfunction (HP:0002839)2.19620773
78Impaired vibratory sensation (HP:0002495)2.19521008
79Hyperthyroidism (HP:0000836)2.17421208
80Incomplete penetrance (HP:0003829)2.17090854
81Nephrogenic diabetes insipidus (HP:0009806)2.14079987
82Torticollis (HP:0000473)2.14039809
83Narrow nasal bridge (HP:0000446)2.12951628
84Hypoventilation (HP:0002791)2.10655690
85Fetal akinesia sequence (HP:0001989)2.09938990
86CNS hypomyelination (HP:0003429)2.09715383
87Urinary urgency (HP:0000012)2.08315466
88Oligomenorrhea (HP:0000876)2.08079048
89Bradykinesia (HP:0002067)2.07659438
90Focal dystonia (HP:0004373)2.06694837
91Dysmetria (HP:0001310)2.05959617
92Blue irides (HP:0000635)2.05546950
93Abnormality of the corticospinal tract (HP:0002492)2.04443384
94Postural instability (HP:0002172)2.04349377
95Abnormality of the lower motor neuron (HP:0002366)2.03639750
96Memory impairment (HP:0002354)2.02861882
97Esotropia (HP:0000565)2.02772333
98Agitation (HP:0000713)2.00182132
99Spastic gait (HP:0002064)1.99526343
100Genetic anticipation (HP:0003743)1.93676135
101Inappropriate behavior (HP:0000719)1.93038545
102Rapidly progressive (HP:0003678)1.92918208
103Scanning speech (HP:0002168)1.91388801
104Spastic tetraplegia (HP:0002510)1.91242530
105Degeneration of the lateral corticospinal tracts (HP:0002314)1.91229156
106Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.91229156
107Mutism (HP:0002300)1.90984691
108Stereotypic behavior (HP:0000733)1.89710579
109Abnormality of pain sensation (HP:0010832)1.89041488
110Impaired pain sensation (HP:0007328)1.89041488
111Hemiparesis (HP:0001269)1.88768502
112Dementia (HP:0000726)1.87894040
113Morphological abnormality of the pyramidal tract (HP:0002062)1.87807273
114Lissencephaly (HP:0001339)1.87545668
115Generalized myoclonic seizures (HP:0002123)1.85820699
116Exotropia (HP:0000577)1.85348160
117Lower limb muscle weakness (HP:0007340)1.83913087
118Status epilepticus (HP:0002133)1.83730844
119Diplopia (HP:0000651)1.83546799
120Abnormality of binocular vision (HP:0011514)1.83546799
121Vaginal atresia (HP:0000148)1.82464601
122Amyotrophic lateral sclerosis (HP:0007354)1.82438790
123Retinal dysplasia (HP:0007973)1.82303306
124Craniofacial dystonia (HP:0012179)1.82231301
125Spinal canal stenosis (HP:0003416)1.81199299
126Genital tract atresia (HP:0001827)1.80700990
127Hypothermia (HP:0002045)1.79803291
128Megalencephaly (HP:0001355)1.78699502
129Resting tremor (HP:0002322)1.78520935
130Akinesia (HP:0002304)1.77440893
131Abnormality of ocular smooth pursuit (HP:0000617)1.76663453
132Dyskinesia (HP:0100660)1.75914353
133Lower limb asymmetry (HP:0100559)1.75671475
134Psychosis (HP:0000709)1.74885403
135Abnormality of salivation (HP:0100755)1.74520501
136Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.71749337
137Increased circulating renin level (HP:0000848)1.71584318
138Gait ataxia (HP:0002066)1.71113472
139Iris hypopigmentation (HP:0007730)1.70362232

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.13977877
2MARK13.86500424
3NTRK33.78435400
4MAP3K43.21563482
5MAP3K93.11790248
6MAP2K73.08957825
7EPHA42.90900283
8MAP3K122.89446647
9DAPK22.79236426
10MINK12.65548154
11NTRK22.11872667
12DAPK12.02941944
13MAP2K41.90441012
14PLK21.76916836
15CDK191.75950087
16MAPK131.58832474
17GRK51.54035390
18PRPF4B1.53375220
19PAK61.50548017
20KSR11.48124433
21SIK31.46604563
22SGK4941.46541962
23SGK2231.46541962
24SGK21.41267565
25AKT31.40429505
26CDK51.39316995
27BMPR1B1.38295750
28ARAF1.35039996
29UHMK11.22818954
30MAP4K21.18038620
31PRKCG1.17747462
32CCNB11.15770312
33MAP3K111.14563998
34CAMKK11.13157290
35CAMKK21.10288260
36TNIK1.10271313
37RIPK11.09694317
38NTRK11.09201467
39BRAF1.07670449
40KSR21.05883516
41BCR1.04570685
42RIPK41.03103445
43NME11.01942917
44CAMK2A0.99497016
45LATS20.94914688
46PRKD30.94345043
47PKN10.93421382
48OXSR10.92845030
49SGK30.91274417
50PNCK0.90585235
51CDK180.89859197
52PHKG20.87410081
53PHKG10.87410081
54CDK140.86761487
55TYRO30.83078101
56PTK2B0.82620200
57CAMK2B0.81929839
58DYRK20.81505890
59CDK150.79937702
60MARK20.79836089
61SIK20.79511884
62MAP2K60.78600330
63BMPR20.75766804
64TSSK60.74563335
65ALK0.73761840
66LMTK20.71706563
67MAP3K20.71017384
68FES0.70501353
69PRKCE0.69366882
70ERBB30.68646041
71LIMK10.68270281
72CDK11A0.66992498
73RPS6KA20.66496245
74DAPK30.64629720
75CSNK1G20.63577989
76CAMK10.63443781
77NEK60.63232714
78PAK30.60282592
79DYRK1A0.60182218
80FGFR20.59705577
81STK380.59632713
82TESK10.58910317
83FER0.57638636
84SGK10.56924161
85WNK30.55728173
86DDR20.54775465
87RET0.54568046
88GRK70.54120571
89PRKCH0.54077550
90BRSK10.53494261
91TRIM280.53299382
92CSNK1A1L0.53162963
93MAPK100.52938990
94ADRBK10.52356383
95TNK20.50590746
96CSNK1G30.50083736
97PINK10.49250989
98MAP2K10.47861307
99WNK40.47701479
100MAPK120.47699336
101PDK30.47661411
102PDK40.47661411
103CAMK40.46676452
104PRKCZ0.45174659
105STK110.43649802
106TAOK20.42494315
107CAMK2G0.41162876
108ADRBK20.40654386
109ROCK20.40325977
110CAMK2D0.40267615
111PDK10.39908856
112FYN0.38368267
113IRAK20.38121018
114MOS0.37307483
115PIK3CA0.37261556
116MYLK0.37166366
117PRKCA0.36651150
118ERBB40.34952371
119PRKACA0.34870718
120CDK80.34695943
121CDC42BPA0.34254499
122INSRR0.33733843
123RPS6KA30.32312557
124PRKCB0.26935485
125ERBB20.26289795
126DYRK1B0.26275741
127CSNK1A10.25246754

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.02837729
2Nicotine addiction_Homo sapiens_hsa050333.87483644
3Collecting duct acid secretion_Homo sapiens_hsa049662.75392435
4GABAergic synapse_Homo sapiens_hsa047272.73270289
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.68613060
6Olfactory transduction_Homo sapiens_hsa047402.57256331
7Circadian entrainment_Homo sapiens_hsa047132.53059696
8Morphine addiction_Homo sapiens_hsa050322.47962948
9Long-term potentiation_Homo sapiens_hsa047202.37619236
10Amphetamine addiction_Homo sapiens_hsa050312.34204804
11Glutamatergic synapse_Homo sapiens_hsa047242.28150232
12Dopaminergic synapse_Homo sapiens_hsa047282.22929574
13Taste transduction_Homo sapiens_hsa047422.05450278
14Insulin secretion_Homo sapiens_hsa049112.02861998
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.00257580
16Vibrio cholerae infection_Homo sapiens_hsa051101.97782940
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.88414625
18Serotonergic synapse_Homo sapiens_hsa047261.85494922
19Oxidative phosphorylation_Homo sapiens_hsa001901.77409545
20Salivary secretion_Homo sapiens_hsa049701.76041948
21Cholinergic synapse_Homo sapiens_hsa047251.74046670
22Cocaine addiction_Homo sapiens_hsa050301.69428007
23Long-term depression_Homo sapiens_hsa047301.65578855
24Renin secretion_Homo sapiens_hsa049241.54651775
25Gastric acid secretion_Homo sapiens_hsa049711.45672447
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.45203427
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44697005
28Gap junction_Homo sapiens_hsa045401.40237690
29Calcium signaling pathway_Homo sapiens_hsa040201.39795089
30* Aldosterone synthesis and secretion_Homo sapiens_hsa049251.38456085
31* Oxytocin signaling pathway_Homo sapiens_hsa049211.37724024
32Parkinsons disease_Homo sapiens_hsa050121.33258308
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32128847
34Cardiac muscle contraction_Homo sapiens_hsa042601.26443808
35Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.24646701
36Alzheimers disease_Homo sapiens_hsa050101.22544129
37Axon guidance_Homo sapiens_hsa043601.17641441
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16026397
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13788516
40Phototransduction_Homo sapiens_hsa047441.11282429
41GnRH signaling pathway_Homo sapiens_hsa049121.09942782
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06650813
43cAMP signaling pathway_Homo sapiens_hsa040241.02979194
44Type II diabetes mellitus_Homo sapiens_hsa049301.00322307
45SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98430999
46Melanogenesis_Homo sapiens_hsa049160.94126160
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93203408
48Huntingtons disease_Homo sapiens_hsa050160.93100092
49ErbB signaling pathway_Homo sapiens_hsa040120.92729559
50Vitamin B6 metabolism_Homo sapiens_hsa007500.92549492
51Estrogen signaling pathway_Homo sapiens_hsa049150.91991121
52Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91005705
53Glioma_Homo sapiens_hsa052140.89446402
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84126278
55Oocyte meiosis_Homo sapiens_hsa041140.75819832
56Type I diabetes mellitus_Homo sapiens_hsa049400.74472618
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70018197
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.67904552
59Phagosome_Homo sapiens_hsa041450.67547954
60Bile secretion_Homo sapiens_hsa049760.66811359
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64916934
62MAPK signaling pathway_Homo sapiens_hsa040100.62575401
63Rheumatoid arthritis_Homo sapiens_hsa053230.61455427
64Alcoholism_Homo sapiens_hsa050340.61040786
65Dilated cardiomyopathy_Homo sapiens_hsa054140.56601659
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56028510
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55718095
68Glucagon signaling pathway_Homo sapiens_hsa049220.55654530
69Choline metabolism in cancer_Homo sapiens_hsa052310.55347570
70Butanoate metabolism_Homo sapiens_hsa006500.54699581
71Thyroid hormone synthesis_Homo sapiens_hsa049180.53453719
72Ras signaling pathway_Homo sapiens_hsa040140.52950677
73Circadian rhythm_Homo sapiens_hsa047100.51695077
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.49053567
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48519621
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.47478146
77Dorso-ventral axis formation_Homo sapiens_hsa043200.47142736
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.46765067
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46325128
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46207612
81Pancreatic secretion_Homo sapiens_hsa049720.45817598
82Endometrial cancer_Homo sapiens_hsa052130.45569548
83Renal cell carcinoma_Homo sapiens_hsa052110.42642060
84Wnt signaling pathway_Homo sapiens_hsa043100.41330304
85African trypanosomiasis_Homo sapiens_hsa051430.39161263
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38983178
87Rap1 signaling pathway_Homo sapiens_hsa040150.38945560
88Insulin signaling pathway_Homo sapiens_hsa049100.38705475
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38603454
90Mineral absorption_Homo sapiens_hsa049780.38571722
91Salmonella infection_Homo sapiens_hsa051320.38010129
92Prion diseases_Homo sapiens_hsa050200.36800983
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36594546
94Inositol phosphate metabolism_Homo sapiens_hsa005620.36069663
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35637435
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35563057
97Regulation of autophagy_Homo sapiens_hsa041400.35236565
98Melanoma_Homo sapiens_hsa052180.34869623
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.33839737
100Endocytosis_Homo sapiens_hsa041440.33472897
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32589120
102VEGF signaling pathway_Homo sapiens_hsa043700.32223691
103Lysosome_Homo sapiens_hsa041420.32058674
104Colorectal cancer_Homo sapiens_hsa052100.29764617
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29340338
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28675947
107Arginine and proline metabolism_Homo sapiens_hsa003300.28591065
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.28539450
109Non-small cell lung cancer_Homo sapiens_hsa052230.28322192
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27497159
111Nitrogen metabolism_Homo sapiens_hsa009100.23754409
112Hippo signaling pathway_Homo sapiens_hsa043900.19413950
113Ovarian steroidogenesis_Homo sapiens_hsa049130.15963700
114Fatty acid biosynthesis_Homo sapiens_hsa000610.15555143

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