CAMK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1amino sugar catabolic process (GO:0046348)5.22119555
2N-acetylneuraminate metabolic process (GO:0006054)4.82471629
3negative regulation of interleukin-12 production (GO:0032695)4.66013529
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.55937471
5regulation of interferon-beta biosynthetic process (GO:0045357)4.49029196
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.36309188
7positive regulation by organism of defense response of other organism involved in symbiotic interact4.36309188
8modulation by symbiont of host immune response (GO:0052553)4.36309188
9positive regulation by symbiont of host defense response (GO:0052509)4.36309188
10modulation by symbiont of host defense response (GO:0052031)4.36309188
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.36309188
12glycosphingolipid catabolic process (GO:0046479)4.19726078
13positive regulation of mast cell activation (GO:0033005)4.00283156
14positive regulation of mast cell activation involved in immune response (GO:0033008)3.94779755
15positive regulation of mast cell degranulation (GO:0043306)3.94779755
16positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.94616465
17apoptotic cell clearance (GO:0043277)3.79608588
18cellular extravasation (GO:0045123)3.76391855
19macrophage activation involved in immune response (GO:0002281)3.72913186
20glycolipid catabolic process (GO:0019377)3.69645173
21regulation of mast cell degranulation (GO:0043304)3.65370406
22regulation of mononuclear cell migration (GO:0071675)3.50566636
23microglial cell activation (GO:0001774)3.46851836
24regulation of mast cell activation involved in immune response (GO:0033006)3.41780992
25keratan sulfate catabolic process (GO:0042340)3.40868173
26oligosaccharide catabolic process (GO:0009313)3.39094074
27ceramide catabolic process (GO:0046514)3.37921373
28regulation of mast cell activation (GO:0033003)3.36225114
29hydrogen peroxide biosynthetic process (GO:0050665)3.34265788
30positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.30227191
31negative regulation of granulocyte differentiation (GO:0030853)3.25287483
32reactive oxygen species biosynthetic process (GO:1903409)3.20744850
33regulation of myeloid leukocyte mediated immunity (GO:0002886)3.18221718
34positive regulation of chemokine biosynthetic process (GO:0045080)3.15360162
35lipopolysaccharide-mediated signaling pathway (GO:0031663)3.14688949
36adenosine receptor signaling pathway (GO:0001973)3.13673576
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.13052106
38response to host immune response (GO:0052572)3.13052106
39low-density lipoprotein particle clearance (GO:0034383)3.12043414
40positive regulation of leukocyte degranulation (GO:0043302)3.11535795
41cellular response to cadmium ion (GO:0071276)3.10183387
42regulation of leukocyte degranulation (GO:0043300)3.09249848
43ATP hydrolysis coupled proton transport (GO:0015991)3.05821067
44energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.05821067
45lysosome organization (GO:0007040)3.05552318
46lytic vacuole organization (GO:0080171)3.05552318
47barbed-end actin filament capping (GO:0051016)3.04326027
48response to host defenses (GO:0052200)3.03087679
49response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.03087679
50response to host (GO:0075136)3.03087679
51mannose metabolic process (GO:0006013)2.98607983
52intracellular pH reduction (GO:0051452)2.94818116
53positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.92172144
54immunoglobulin mediated immune response (GO:0016064)2.90923082
55plasma membrane repair (GO:0001778)2.90766694
56transferrin transport (GO:0033572)2.90584072
57positive regulation of chemokine secretion (GO:0090197)2.90451212
58positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.88132657
59virion attachment to host cell (GO:0019062)2.86933680
60adhesion of symbiont to host cell (GO:0044650)2.86933680
61negative regulation of mast cell activation (GO:0033004)2.80895316
62membrane lipid catabolic process (GO:0046466)2.79578084
63pH reduction (GO:0045851)2.78364756
64sphingolipid catabolic process (GO:0030149)2.78057776
65platelet dense granule organization (GO:0060155)2.75871127
66synaptic vesicle maturation (GO:0016188)2.75322159
67negative regulation of nitric oxide biosynthetic process (GO:0045019)2.75214045
68positive regulation of monocyte chemotaxis (GO:0090026)2.74834542
69regulation of regulated secretory pathway (GO:1903305)2.74283549
70cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.73784502
71respiratory burst (GO:0045730)2.72416831
72trivalent inorganic cation transport (GO:0072512)2.70865498
73ferric iron transport (GO:0015682)2.70865498
74monocyte chemotaxis (GO:0002548)2.69382982
75positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.68636429
76regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.66977165
77regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.65468632
78regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.64720537
79negative regulation of cell killing (GO:0031342)2.64018740
80negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.64018740
81positive regulation of cellular amide metabolic process (GO:0034250)2.63838661
82protein localization to endosome (GO:0036010)2.63825477
83neuromuscular process controlling posture (GO:0050884)2.63396522
84ganglioside metabolic process (GO:0001573)2.62544590
85regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.62307275
86adhesion of symbiont to host (GO:0044406)2.61796773
87positive regulation of gamma-delta T cell activation (GO:0046645)2.60512592
88regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.60448950
89myeloid dendritic cell differentiation (GO:0043011)2.59756695
90response to acidic pH (GO:0010447)2.59649680
91response to interferon-alpha (GO:0035455)2.59207996
92stress fiber assembly (GO:0043149)2.58178583
93positive regulation of heat generation (GO:0031652)2.58054738
94regulation of chemokine biosynthetic process (GO:0045073)2.57945396
95macrophage activation (GO:0042116)2.57627520
96positive regulation of macrophage cytokine production (GO:0060907)2.57103551
97positive regulation of interferon-alpha production (GO:0032727)2.56674938
98eosinophil chemotaxis (GO:0048245)2.55696782
99granulocyte activation (GO:0036230)2.54693229
100response to thyroid hormone (GO:0097066)2.53843024
101negative regulation of interleukin-1 beta production (GO:0032691)2.53800193
102regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.52269170
103superoxide anion generation (GO:0042554)2.51417126
104cellular response to arsenic-containing substance (GO:0071243)2.51226011
105substrate-dependent cell migration (GO:0006929)2.50533059
106regulation of superoxide anion generation (GO:0032928)2.47687709
107pinocytosis (GO:0006907)2.46576733
108plasma lipoprotein particle clearance (GO:0034381)2.46317292
109regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.43606700
110positive regulation of regulated secretory pathway (GO:1903307)2.42003338
111cortical actin cytoskeleton organization (GO:0030866)2.41968764
112positive regulation of cholesterol efflux (GO:0010875)2.41807986
113synaptic vesicle exocytosis (GO:0016079)2.40737940
114cell communication by electrical coupling (GO:0010644)2.40458116
115cell adhesion mediated by integrin (GO:0033627)2.39875517
116negative regulation of interleukin-1 production (GO:0032692)2.38451936
117regulation of cholesterol storage (GO:0010885)2.36687336
118regulation of interferon-alpha production (GO:0032647)2.35644568
119chondroitin sulfate catabolic process (GO:0030207)2.35564924
120vascular endothelial growth factor signaling pathway (GO:0038084)2.34998905
121neutrophil activation involved in immune response (GO:0002283)2.32415038
122relaxation of cardiac muscle (GO:0055119)2.30760566
123cardiac myofibril assembly (GO:0055003)2.30449996
124* regulation of synapse structural plasticity (GO:0051823)2.28821430
125regulation of macrophage cytokine production (GO:0010935)2.24634938
126peptidyl-proline hydroxylation (GO:0019511)2.24076906
127cortical cytoskeleton organization (GO:0030865)2.23198033
128positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.23052592
129activation of protein kinase A activity (GO:0034199)2.23018818
130cellular response to thyroid hormone stimulus (GO:0097067)2.22004893
131protein hydroxylation (GO:0018126)2.21731885
132I-kappaB phosphorylation (GO:0007252)2.21675895
133positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.21616022
134positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.20421902
135negative regulation of erythrocyte differentiation (GO:0045647)2.18491324
136positive regulation of p38MAPK cascade (GO:1900745)2.17131466
137regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.17033037
138negative regulation of interleukin-6 production (GO:0032715)2.16203750
139response to peptidoglycan (GO:0032494)2.15450167
140negative regulation of interleukin-17 production (GO:0032700)2.15281096
141regulation of p38MAPK cascade (GO:1900744)2.14682455
142sodium ion export (GO:0071436)2.14110867
143alanine transport (GO:0032328)2.13347063
144hyaluronan catabolic process (GO:0030214)2.12381111
145endothelial cell chemotaxis (GO:0035767)2.11506450
146heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.11029616
147negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.10346194
148protein retention in ER lumen (GO:0006621)2.10331390
149maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.10145660
150phagocytosis, engulfment (GO:0006911)2.09511671
151toxin transport (GO:1901998)2.09074722
152macrophage differentiation (GO:0030225)2.08692265
153endosome to pigment granule transport (GO:0043485)2.07826348
154endosome to melanosome transport (GO:0035646)2.07826348
155regulation of cell communication by electrical coupling (GO:0010649)2.07431986
156cytokine production involved in immune response (GO:0002367)2.05821322
157heparin metabolic process (GO:0030202)2.05036329
158heparin biosynthetic process (GO:0030210)2.05036329
159positive regulation of antigen processing and presentation (GO:0002579)2.04530330
160negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.04007131
161regulation of macrophage chemotaxis (GO:0010758)2.02936211
162response to fluid shear stress (GO:0034405)2.02334037
163negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.02108460
164detection of molecule of bacterial origin (GO:0032490)2.02060687
165synaptic vesicle docking involved in exocytosis (GO:0016081)2.00152508
166regulation of calcium ion transmembrane transport (GO:1903169)1.99861949
167regulation of calcium ion transmembrane transporter activity (GO:1901019)1.99861949
168regulation of B cell receptor signaling pathway (GO:0050855)1.99154679
169phagosome maturation (GO:0090382)1.98808484
170platelet aggregation (GO:0070527)1.98695509
171phosphatidylglycerol biosynthetic process (GO:0006655)1.98069270
172myeloid cell activation involved in immune response (GO:0002275)1.97900066

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RARG_19884340_ChIP-ChIP_MEFs_Mouse3.16084029
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.11064761
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.86234915
4IRF8_21731497_ChIP-ChIP_J774_Mouse2.50842060
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.35679154
6* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.35646766
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.28756462
8IRF8_27001747_Chip-Seq_BMDM_Mouse2.26860515
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.17781562
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.14542158
11TRIM28_21343339_ChIP-Seq_HEK293_Human1.99744145
12TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.99549904
13* LXR_22292898_ChIP-Seq_THP-1_Human1.94581219
14KDM2B_26808549_Chip-Seq_SUP-B15_Human1.94575634
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93865518
16SPI1_23127762_ChIP-Seq_K562_Human1.92370484
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.89364665
18SCL_19346495_ChIP-Seq_HPC-7_Human1.88331441
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.83156521
20GATA2_21666600_ChIP-Seq_HMVEC_Human1.80000554
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.78946854
22ELK3_25401928_ChIP-Seq_HUVEC_Human1.74704318
23SRY_22984422_ChIP-ChIP_TESTIS_Rat1.72564724
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.70228579
25MYB_21317192_ChIP-Seq_ERMYB_Mouse1.67854070
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.65061047
27* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.64449527
28SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.63891054
29* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.59819098
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56278981
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55577852
32GATA1_22025678_ChIP-Seq_K562_Human1.53000453
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.52878742
34SPI1_23547873_ChIP-Seq_NB4_Human1.52696996
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52152109
36DROSHA_22980978_ChIP-Seq_HELA_Human1.49513007
37ELF1_20517297_ChIP-Seq_JURKAT_Human1.48310323
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.48282270
39PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.46877478
40PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.46462045
41RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46031808
42ESR1_21235772_ChIP-Seq_MCF-7_Human1.44293623
43CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43982129
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43394427
45CLOCK_20551151_ChIP-Seq_293T_Human1.42021445
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41421287
47* BCOR_27268052_Chip-Seq_Bcells_Human1.40827350
48VDR_24763502_ChIP-Seq_THP-1_Human1.40668148
49VDR_21846776_ChIP-Seq_THP-1_Human1.40280300
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.38632380
51STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.37578733
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37377132
53PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36767380
54* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36568485
55* P68_20966046_ChIP-Seq_HELA_Human1.34174329
56MTF2_20144788_ChIP-Seq_MESCs_Mouse1.32874736
57TET1_21451524_ChIP-Seq_MESCs_Mouse1.31679596
58SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31580617
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31081300
60RUNX1_22412390_ChIP-Seq_EML_Mouse1.30707215
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29697864
62SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27968480
63CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27936705
64SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.26577341
65* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25154639
66KDM2B_26808549_Chip-Seq_K562_Human1.24164177
67SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.23941153
68TBX20_22328084_ChIP-Seq_HEART_Mouse1.22734607
69TBX20_22080862_ChIP-Seq_HEART_Mouse1.22734607
70SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22645344
71ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21209119
72SA1_27219007_Chip-Seq_Bcells_Human1.20958458
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.20890996
74DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20781616
75CTCF_26484167_Chip-Seq_Bcells_Mouse1.20631626
76E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20584483
77MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19195077
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19064478
79EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18799158
80ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.18104269
81SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17878957
82CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17850614
83RNF2_18974828_ChIP-Seq_MESCs_Mouse1.17710740
84EZH2_18974828_ChIP-Seq_MESCs_Mouse1.17710740
85RACK7_27058665_Chip-Seq_MCF-7_Human1.17700361
86SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.17329997
87SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16275093
88CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16259722
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.16150812
90TCF7_22412390_ChIP-Seq_EML_Mouse1.15639305
91GATA1_19941826_ChIP-Seq_K562_Human1.15628596
92REST_18959480_ChIP-ChIP_MESCs_Mouse1.14833898
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12674450
94SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.12153301
95* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12102836
96* KDM2B_26808549_Chip-Seq_DND41_Human1.11972222
97CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11084441
98CTCF_18555785_ChIP-Seq_MESCs_Mouse1.10509204
99BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.10196022
100CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10034472
101GATA1_19941827_ChIP-Seq_MEL_Mouse1.08133616
102VDR_24787735_ChIP-Seq_THP-1_Human1.07810420
103WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07711325
104RUNX_20019798_ChIP-Seq_JUKART_Human1.07116943
105IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06897526
106PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06874952
107* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.06214867
108CJUN_26792858_Chip-Seq_BT549_Human1.06155086
109* SOX2_20726797_ChIP-Seq_SW620_Human1.05960452
110JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05686289
111EP300_21415370_ChIP-Seq_HL-1_Mouse1.05549423
112PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04891067
113CTCF_20526341_ChIP-Seq_ESCs_Human1.04855269
114* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04766170
115REST_21632747_ChIP-Seq_MESCs_Mouse1.04101783
116* SPI1_20517297_ChIP-Seq_HL60_Human1.04031197
117FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.03797075
118* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03178173
119CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02997970
120IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02746740
121SMC4_20622854_ChIP-Seq_HELA_Human1.02715964
122MAF_26560356_Chip-Seq_TH2_Human1.02230376
123ZNF263_19887448_ChIP-Seq_K562_Human1.02064113
124GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01960633
125STAT1_20625510_ChIP-Seq_HELA_Human0.99457018
126EZH2_22144423_ChIP-Seq_EOC_Human0.99265913
127ERG_21242973_ChIP-ChIP_JURKAT_Human0.99247335
128RXR_22158963_ChIP-Seq_LIVER_Mouse0.99104189
129EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98049304
130LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.97905268
131SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97254435
132GATA2_19941826_ChIP-Seq_K562_Human0.96861633
133* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96837701
134PU_27001747_Chip-Seq_BMDM_Mouse0.95866681
135ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.95554189
136NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.95377597
137TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94905251
138* BCL6_27268052_Chip-Seq_Bcells_Human0.94765469
139UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94555905
140EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92778492
141P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92425447
142GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92341573
143SMC1_22415368_ChIP-Seq_MEFs_Mouse0.91997495
144NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91753202
145ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89518949
146FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.89371060
147SUZ12_27294783_Chip-Seq_ESCs_Mouse0.89261567
148RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88967588

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.23534877
2MP0008438_abnormal_cutaneous_collagen3.85467576
3MP0003172_abnormal_lysosome_physiology2.94801599
4MP0003191_abnormal_cellular_cholesterol2.75665282
5MP0004858_abnormal_nervous_system2.73859119
6MP0000751_myopathy2.61044502
7MP0004130_abnormal_muscle_cell2.52393001
8MP0009840_abnormal_foam_cell2.46480725
9MP0001958_emphysema2.45621307
10MP0003279_aneurysm2.30231456
11MP0004510_myositis2.27479424
12MP0003075_altered_response_to2.19436959
13MP0009785_altered_susceptibility_to2.12753042
14MP0003329_amyloid_beta_deposits2.07530461
15MP0002139_abnormal_hepatobiliary_system2.07004859
16MP0000343_altered_response_to2.02705945
17MP0004084_abnormal_cardiac_muscle2.01097112
18MP0010368_abnormal_lymphatic_system1.99241112
19MP0005671_abnormal_response_to1.98746917
20MP0002909_abnormal_adrenal_gland1.97613459
21MP0005000_abnormal_immune_tolerance1.91350023
22MP0005670_abnormal_white_adipose1.90969807
23MP0003303_peritoneal_inflammation1.86350763
24MP0009764_decreased_sensitivity_to1.85201186
25MP0005387_immune_system_phenotype1.79578921
26MP0001790_abnormal_immune_system1.79578921
27MP0002837_dystrophic_cardiac_calcinosis1.79545523
28MP0003705_abnormal_hypodermis_morpholog1.79056792
29MP0003566_abnormal_cell_adhesion1.75815755
30MP0003879_abnormal_hair_cell1.75187395
31MP0000749_muscle_degeneration1.68916204
32MP0005365_abnormal_bile_salt1.68811080
33MP0000920_abnormal_myelination1.65271649
34MP0003828_pulmonary_edema1.61001779
35MP0002064_seizures1.58748156
36MP0000569_abnormal_digit_pigmentation1.58680680
37MP0009278_abnormal_bone_marrow1.56232668
38MP0003436_decreased_susceptibility_to1.56138917
39MP0002419_abnormal_innate_immunity1.54541531
40MP0003195_calcinosis1.52976924
41MP0001533_abnormal_skeleton_physiology1.52627775
42MP0002723_abnormal_immune_serum1.52190791
43MP0000750_abnormal_muscle_regeneration1.49663452
44MP0005464_abnormal_platelet_physiology1.46567130
45MP0005275_abnormal_skin_tensile1.44089971
46MP0000685_abnormal_immune_system1.43449804
47MP0005310_abnormal_salivary_gland1.43296205
48MP0006082_CNS_inflammation1.42383848
49MP0005167_abnormal_blood-brain_barrier1.40352085
50MP0001845_abnormal_inflammatory_respons1.37498496
51MP0003724_increased_susceptibility_to1.36998345
52MP0004484_altered_response_of1.36277257
53MP0003806_abnormal_nucleotide_metabolis1.35800122
54MP0004859_abnormal_synaptic_plasticity1.34372379
55MP0002420_abnormal_adaptive_immunity1.33072638
56MP0003300_gastrointestinal_ulcer1.31642628
57MP0001853_heart_inflammation1.31514086
58MP0001819_abnormal_immune_cell1.31292478
59MP0001835_abnormal_antigen_presentation1.29128039
60MP0004036_abnormal_muscle_relaxation1.28366335
61MP0004215_abnormal_myocardial_fiber1.27900120
62MP0005165_increased_susceptibility_to1.26924517
63MP0002090_abnormal_vision1.24216435
64MP0001800_abnormal_humoral_immune1.22836994
65MP0002972_abnormal_cardiac_muscle1.22550038
66MP0002405_respiratory_system_inflammati1.22213754
67MP0005166_decreased_susceptibility_to1.22090700
68MP0002998_abnormal_bone_remodeling1.21081284
69MP0003690_abnormal_glial_cell1.19579965
70MP0004272_abnormal_basement_membrane1.17489346
71MP0008004_abnormal_stomach_pH1.16929987
72MP0000013_abnormal_adipose_tissue1.14674703
73MP0000747_muscle_weakness1.14270494
74MP0005330_cardiomyopathy1.12639716
75MP0003183_abnormal_peptide_metabolism1.11873375
76MP0005595_abnormal_vascular_smooth1.10705097
77MP0000767_abnormal_smooth_muscle1.08943849
78MP0009046_muscle_twitch1.08666032
79MP0009115_abnormal_fat_cell1.08572482
80MP0004087_abnormal_muscle_fiber1.07736692
81MP0001501_abnormal_sleep_pattern1.07351594
82MP0005666_abnormal_adipose_tissue1.06208979
83MP0003880_abnormal_central_pattern1.05647843
84MP0001879_abnormal_lymphatic_vessel1.05584064
85MP0008874_decreased_physiological_sensi1.05124314
86MP0001984_abnormal_olfaction1.03191466
87MP0005503_abnormal_tendon_morphology1.02472318
88MP0000465_gastrointestinal_hemorrhage1.02342782
89MP0003635_abnormal_synaptic_transmissio1.02288902
90MP0008775_abnormal_heart_ventricle1.01090879
91MP0009745_abnormal_behavioral_response1.00838547
92MP0003646_muscle_fatigue1.00259632
93MP0003631_nervous_system_phenotype1.00241612
94MP0002063_abnormal_learning/memory/cond0.98399264
95MP0002933_joint_inflammation0.97535634
96MP0001544_abnormal_cardiovascular_syste0.95888380
97MP0005385_cardiovascular_system_phenoty0.95888380
98MP0000858_altered_metastatic_potential0.95501392
99MP0004185_abnormal_adipocyte_glucose0.93833404
100MP0001970_abnormal_pain_threshold0.93586822
101MP0003448_altered_tumor_morphology0.93501132
102MP0003091_abnormal_cell_migration0.93480023
103MP0000604_amyloidosis0.93459256
104MP0001545_abnormal_hematopoietic_system0.92985367
105MP0005397_hematopoietic_system_phenotyp0.92985367
106MP0005375_adipose_tissue_phenotype0.92179634
107MP0005620_abnormal_muscle_contractility0.91799306
108MP0010329_abnormal_lipoprotein_level0.91515497
109MP0005623_abnormal_meninges_morphology0.90613313
110MP0003011_delayed_dark_adaptation0.89405690
111MP0004145_abnormal_muscle_electrophysio0.89069905
112MP0005083_abnormal_biliary_tract0.88741906
113MP0002971_abnormal_brown_adipose0.87393237
114MP0002295_abnormal_pulmonary_circulatio0.86545368
115MP0005535_abnormal_body_temperature0.86193985
116MP0000230_abnormal_systemic_arterial0.84622749
117MP0002148_abnormal_hypersensitivity_rea0.83648653
118MP0009333_abnormal_splenocyte_physiolog0.83610143
119MP0005451_abnormal_body_composition0.83559181
120MP0002118_abnormal_lipid_homeostasis0.83062851
121MP0002277_abnormal_respiratory_mucosa0.83051645
122MP0004742_abnormal_vestibular_system0.82107292
123MP0002106_abnormal_muscle_physiology0.81581086
124MP0005390_skeleton_phenotype0.81108507
125MP0003186_abnormal_redox_activity0.80457379
126MP0005584_abnormal_enzyme/coenzyme_acti0.79628532
127MP0000249_abnormal_blood_vessel0.79143267
128MP0003045_fibrosis0.78344354
129MP0001542_abnormal_bone_strength0.78029682
130MP0008260_abnormal_autophagy0.77028526
131MP0002269_muscular_atrophy0.77004241
132MP0000759_abnormal_skeletal_muscle0.76364586
133MP0002733_abnormal_thermal_nociception0.76362772
134MP0004947_skin_inflammation0.76265514
135MP0001663_abnormal_digestive_system0.76034678
136MP0008469_abnormal_protein_level0.76013723
137MP0001440_abnormal_grooming_behavior0.75873106
138MP0000716_abnormal_immune_system0.75260597
139MP0005025_abnormal_response_to0.74980158
140MP0004085_abnormal_heartbeat0.74901615
141MP0002396_abnormal_hematopoietic_system0.74556371
142MP0001968_abnormal_touch/_nociception0.74544255
143MP0002229_neurodegeneration0.74286985
144MP0005164_abnormal_response_to0.73984423
145MP0002572_abnormal_emotion/affect_behav0.73049587
146MP0002452_abnormal_antigen_presenting0.72967675
147MP0003632_abnormal_nervous_system0.72392459
148MP0003634_abnormal_glial_cell0.71823601
149MP0003633_abnormal_nervous_system0.71586772
150MP0002896_abnormal_bone_mineralization0.70331170
151MP0000003_abnormal_adipose_tissue0.69630127
152MP0004883_abnormal_blood_vessel0.69405898
153MP0005174_abnormal_tail_pigmentation0.68987784
154MP0001873_stomach_inflammation0.68942025

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)4.83099465
2Increased cerebral lipofuscin (HP:0011813)4.75259209
3Dysostosis multiplex (HP:0000943)4.59742633
4Cerebral aneurysm (HP:0004944)4.15090645
5Abnormality of glycolipid metabolism (HP:0010969)4.06664926
6Abnormality of liposaccharide metabolism (HP:0010968)4.06664926
7Abnormality of glycosphingolipid metabolism (HP:0004343)4.06664926
8Vacuolated lymphocytes (HP:0001922)4.04604458
9Asymmetric septal hypertrophy (HP:0001670)4.01444161
10Increased neuronal autofluorescent lipopigment (HP:0002074)3.98224936
11Urinary glycosaminoglycan excretion (HP:0003541)3.74423796
12Mucopolysacchariduria (HP:0008155)3.74423796
13Abnormality of mucopolysaccharide metabolism (HP:0011020)3.64247668
14Abnormality of polysaccharide metabolism (HP:0011012)3.64247668
15Abnormality of glycosaminoglycan metabolism (HP:0004371)3.64247668
16Glomerulonephritis (HP:0000099)3.57842042
17Upper motor neuron abnormality (HP:0002127)3.47106734
18Neurofibrillary tangles (HP:0002185)3.42333357
19Hand muscle atrophy (HP:0009130)3.29533533
20Autoimmune thrombocytopenia (HP:0001973)3.16031099
21Loss of speech (HP:0002371)3.15411673
22Arterial tortuosity (HP:0005116)3.11177920
23Protrusio acetabuli (HP:0003179)3.09597329
24Amyloidosis (HP:0011034)3.05254030
25Agnosia (HP:0010524)2.97364936
26Aortic aneurysm (HP:0004942)2.96663949
27Upper limb amyotrophy (HP:0009129)2.94920284
28Distal upper limb amyotrophy (HP:0007149)2.94920284
29Mediastinal lymphadenopathy (HP:0100721)2.92594866
30Vascular tortuosity (HP:0004948)2.92054178
31Mutism (HP:0002300)2.88690180
32Chronic obstructive pulmonary disease (HP:0006510)2.88657581
33Obstructive lung disease (HP:0006536)2.88657581
34Recurrent abscess formation (HP:0002722)2.85663088
35Purpura (HP:0000979)2.78223602
36Inappropriate behavior (HP:0000719)2.76862518
37Axonal loss (HP:0003447)2.76787637
38Stomatitis (HP:0010280)2.75413671
39Apathy (HP:0000741)2.73670111
40Aortic dissection (HP:0002647)2.73118985
41Bone cyst (HP:0012062)2.69149160
42Myocardial infarction (HP:0001658)2.67218278
43Broad metatarsal (HP:0001783)2.65504331
44Premature rupture of membranes (HP:0001788)2.64743724
45Vertebral compression fractures (HP:0002953)2.64334470
46Nuclear cataract (HP:0100018)2.64181165
47Cerebral inclusion bodies (HP:0100314)2.62574151
48Myositis (HP:0100614)2.58342740
49Striae distensae (HP:0001065)2.57401685
50J-shaped sella turcica (HP:0002680)2.56851469
51Complement deficiency (HP:0004431)2.56424234
52Retinal atrophy (HP:0001105)2.54499854
53Dementia (HP:0000726)2.52809509
54Hepatosplenomegaly (HP:0001433)2.49303534
55Hematochezia (HP:0002573)2.49229600
56Joint stiffness (HP:0001387)2.45692730
57Ankle contracture (HP:0006466)2.44387196
58Tetraparesis (HP:0002273)2.44375221
59Orchitis (HP:0100796)2.43193759
60Cervical subluxation (HP:0003308)2.43186988
61Progressive neurologic deterioration (HP:0002344)2.43020976
62Recurrent bacterial skin infections (HP:0005406)2.39165649
63Personality changes (HP:0000751)2.38201276
64Recurrent skin infections (HP:0001581)2.38111265
65Prolonged neonatal jaundice (HP:0006579)2.32639458
66Global brain atrophy (HP:0002283)2.32060460
67Abnormality of complement system (HP:0005339)2.30463060
68Visual hallucinations (HP:0002367)2.28127714
69Abnormality of macrophages (HP:0004311)2.23414708
70Ovoid vertebral bodies (HP:0003300)2.22916371
71Nephritis (HP:0000123)2.21964693
72Optic neuritis (HP:0100653)2.21885610
73Retrobulbar optic neuritis (HP:0100654)2.21885610
74Xanthomatosis (HP:0000991)2.21476356
75Beaking of vertebral bodies (HP:0004568)2.18954906
76Neuronal loss in central nervous system (HP:0002529)2.16665730
77Increased serum ferritin (HP:0003281)2.16459709
78Petechiae (HP:0000967)2.14685036
79Eczematoid dermatitis (HP:0000976)2.12719694
80Interstitial pulmonary disease (HP:0006530)2.11137544
81Abnormality of the periventricular white matter (HP:0002518)2.10882337
82Disinhibition (HP:0000734)2.10421767
83Abnormality of the vasculature of the conjunctiva (HP:0008054)2.09941859
84Gingivitis (HP:0000230)2.08897360
85Difficulty climbing stairs (HP:0003551)2.08361019
86Atrial fibrillation (HP:0005110)2.08125935
87Thoracic kyphosis (HP:0002942)2.02417870
88Mesangial abnormality (HP:0001966)1.99236121
89Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.98698049
90Sudden death (HP:0001699)1.98509742
91Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.97486632
92Diplopia (HP:0000651)1.97399245
93Abnormality of binocular vision (HP:0011514)1.97399245
94Type 1 muscle fiber predominance (HP:0003803)1.96475736
95Spinal rigidity (HP:0003306)1.95914624
96Increased variability in muscle fiber diameter (HP:0003557)1.95213667
97Growth hormone excess (HP:0000845)1.94618532
98Aneurysm (HP:0002617)1.94589855
99Primary atrial arrhythmia (HP:0001692)1.94339657
100Esophageal neoplasm (HP:0100751)1.94332002
101Neoplasm of head and neck (HP:0012288)1.94332002
102Myotonia (HP:0002486)1.92662828
103Oligomenorrhea (HP:0000876)1.92401775
104Memory impairment (HP:0002354)1.91288047
105Myokymia (HP:0002411)1.90740292
106Lipoatrophy (HP:0100578)1.90617705
107Shallow orbits (HP:0000586)1.90303788
108Soft skin (HP:0000977)1.88969155
109Rapidly progressive (HP:0003678)1.88739872
110Peripheral demyelination (HP:0011096)1.88728750
111Spontaneous hematomas (HP:0007420)1.88473398
112Delusions (HP:0000746)1.88112949
113Supraventricular tachycardia (HP:0004755)1.87028309
114Palpitations (HP:0001962)1.86949060
115Supraventricular arrhythmia (HP:0005115)1.86209160
116Abnormal eating behavior (HP:0100738)1.85241284
117Agitation (HP:0000713)1.84959689
118Cardiomegaly (HP:0001640)1.84244434
119Recurrent fungal infections (HP:0002841)1.84085866
120Generalized amyotrophy (HP:0003700)1.82421483
121Abnormality of the lumbar spine (HP:0100712)1.81907964
122Ventricular tachycardia (HP:0004756)1.80439339
123Frequent falls (HP:0002359)1.79562827
124Pathologic fracture (HP:0002756)1.77665174
125Progressive visual loss (HP:0000529)1.77294987
126Bundle branch block (HP:0011710)1.77173627
127Exercise-induced muscle cramps (HP:0003710)1.77009233
128Diminished motivation (HP:0000745)1.76879149
129Abnormality of skeletal muscle fiber size (HP:0012084)1.76839523
130Dilatation of the ascending aorta (HP:0005111)1.75517365
131Achilles tendon contracture (HP:0001771)1.75091133
132Mitral valve prolapse (HP:0001634)1.74833927
133Polyphagia (HP:0002591)1.74829287
134Pulmonary infiltrates (HP:0002113)1.74532611
135Facial diplegia (HP:0001349)1.74320317
136Supranuclear gaze palsy (HP:0000605)1.74313145
137Enlarged penis (HP:0000040)1.74062440
138Recurrent gram-negative bacterial infections (HP:0005420)1.73894658
139Myoclonus (HP:0001336)1.73790507
140Spondylolisthesis (HP:0003302)1.73705862
141Muscle fiber splitting (HP:0003555)1.72615228
142Increased connective tissue (HP:0009025)1.71781702
143Metaphyseal irregularity (HP:0003025)1.71763358
144Elevated erythrocyte sedimentation rate (HP:0003565)1.71374080
145Hemoptysis (HP:0002105)1.71259874
146Abnormal neuron morphology (HP:0012757)1.70851972
147Abnormality of the motor neurons (HP:0002450)1.70851972
148Basal ganglia calcification (HP:0002135)1.69131454
149Deformed sella turcica (HP:0002681)1.68824032
150Bladder diverticulum (HP:0000015)1.67774298
151Urticaria (HP:0001025)1.67662312
152Polygenic inheritance (HP:0010982)1.67492856
153Fragile skin (HP:0001030)1.67057128
154Nausea (HP:0002018)1.66499662
155Abnormality of iron homeostasis (HP:0011031)1.65624092
156Polyneuropathy (HP:0001271)1.64602603
157Hemiplegia (HP:0002301)1.63949409
158Increased CSF protein (HP:0002922)1.59972961
159Meningitis (HP:0001287)1.56587328
160Spastic tetraparesis (HP:0001285)1.54567399
161Bone pain (HP:0002653)1.53432595

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR24.39124542
2IRAK33.67338653
3TRIB33.64989445
4TTN2.93645644
5RIPK12.83609642
6ERN12.72351102
7NME22.69568094
8KIT2.55687238
9PKN22.52899826
10ARAF2.35150537
11TBK12.11280368
12SCYL21.99655522
13MAP3K91.91704737
14MYLK1.88418069
15RIPK41.83314479
16ABL21.77652197
17TESK11.77511385
18TIE11.72784204
19EPHA41.70683019
20CSF1R1.65748353
21CSK1.58712177
22MAP2K31.56040416
23KSR21.49998063
24FGR1.48698321
25LMTK21.46511731
26GRK71.45871700
27TAOK21.44855079
28MAP4K11.44756871
29PHKG11.44047503
30PHKG21.44047503
31PRKD31.42344229
32PAK41.39603183
33DAPK21.37822128
34CCNB11.36724859
35TESK21.35188208
36PRPF4B1.32811136
37FES1.31270007
38PDGFRA1.28919919
39TNK21.23197916
40LRRK21.22195524
41DAPK31.19724898
42ACVR1B1.19296905
43ADRBK21.17514246
44TYK21.16283058
45MATK1.15319190
46IKBKB1.14630480
47PTK61.12761313
48MOS1.12623494
49TLK11.11792534
50SIK11.10260486
51BLK1.07212242
52MAP3K131.06186597
53MAP3K121.03824631
54DDR21.03210020
55MAPKAPK31.02014163
56BCKDK1.00311993
57PAK61.00163998
58PIM20.99552180
59IRAK20.97023219
60PRKG20.90432576
61IRAK40.87940788
62MAPKAPK50.87717616
63TYRO30.87648533
64MAP3K140.86623611
65CDC42BPA0.86171819
66FLT30.85884785
67MAP2K10.85845950
68ILK0.85428662
69SIK20.83898351
70NTRK30.83666912
71MAPK150.83145943
72RET0.83057397
73ZAP700.83034421
74MAPK120.81810424
75EPHB20.81430155
76JAK30.81121202
77MAP2K60.81050312
78* CAMKK10.78653421
79MARK20.77439222
80DAPK10.76327830
81LYN0.75836412
82MST1R0.75020327
83PDPK10.74488309
84JAK10.74128333
85MAP3K40.73743324
86MAP3K70.73591695
87MAP2K40.73393717
88HCK0.71995150
89NTRK10.71821084
90RAF10.71296348
91PAK20.70961792
92CSNK1G30.70207251
93NEK90.69565262
94PINK10.69263374
95MAP3K30.67068531
96RPS6KA20.66739226
97IKBKE0.64668489
98PRKCG0.64648335
99* CAMK10.63353357
100PAK30.63031511
101MAP3K10.63029055
102PRKCH0.62901681
103TAOK10.62796546
104FER0.60355628
105PTK2B0.59896301
106PRKD20.58646859
107CSNK1G20.58450183
108DMPK0.56208973
109CDK190.55204348
110EPHB10.54333875
111PDK10.52922292
112LIMK10.51931342
113MAP3K110.51556632
114PRKD10.51297211
115CSNK1A1L0.50711751
116KDR0.50638297
117MAP2K20.50588396
118RPS6KA60.49559447
119PKN10.49442392
120TRPM70.48899808
121MAP3K50.48841105
122MUSK0.48170947
123STK380.47912076
124TXK0.47891096
125PIK3CG0.47627126
126LCK0.46655206
127SMG10.46390375
128BMPR20.46077569
129JAK20.45317293
130CAMK2D0.45235538
131MAPK40.44984086
132MINK10.43189627
133PTK20.42751552
134SYK0.42705501
135RPS6KC10.42395776
136RPS6KL10.42395776
137EEF2K0.41564633
138STK110.41372244
139CDK140.40720395
140GRK50.40009199
141TEC0.39130271
142CDK150.38544302
143* CAMK40.38028233
144PRKCE0.37640203
145MAP2K70.37269496
146SRC0.37247394
147CDK50.37125404
148PIK3CA0.37021483
149ADRBK10.35695683
150CDK11A0.33624031

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005313.31805223
2Other glycan degradation_Homo sapiens_hsa005113.02846429
3Lysosome_Homo sapiens_hsa041422.89395309
4Staphylococcus aureus infection_Homo sapiens_hsa051502.11072468
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.00455175
6Synaptic vesicle cycle_Homo sapiens_hsa047211.73335354
7Pertussis_Homo sapiens_hsa051331.71828467
8Olfactory transduction_Homo sapiens_hsa047401.67214655
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.62283558
10Allograft rejection_Homo sapiens_hsa053301.60443485
11Phagosome_Homo sapiens_hsa041451.55960485
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.54913387
13Dilated cardiomyopathy_Homo sapiens_hsa054141.54836583
14Caffeine metabolism_Homo sapiens_hsa002321.54211699
15Vitamin B6 metabolism_Homo sapiens_hsa007501.53668550
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.52295913
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.50678140
18Osteoclast differentiation_Homo sapiens_hsa043801.50476771
19Leishmaniasis_Homo sapiens_hsa051401.45882936
20Asthma_Homo sapiens_hsa053101.45768803
21Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.41345616
22Graft-versus-host disease_Homo sapiens_hsa053321.37317005
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.37170425
24Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.36354121
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.34306241
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.33342431
27Tuberculosis_Homo sapiens_hsa051521.29364384
28Prion diseases_Homo sapiens_hsa050201.27240418
29Collecting duct acid secretion_Homo sapiens_hsa049661.26356943
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.25114149
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22778356
32Autoimmune thyroid disease_Homo sapiens_hsa053201.21548024
33Platelet activation_Homo sapiens_hsa046111.21419688
34PPAR signaling pathway_Homo sapiens_hsa033201.20291885
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.19588354
36Sulfur relay system_Homo sapiens_hsa041221.14737755
37Antigen processing and presentation_Homo sapiens_hsa046121.13562679
38Vibrio cholerae infection_Homo sapiens_hsa051101.12013433
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11625091
40Type I diabetes mellitus_Homo sapiens_hsa049401.08280220
41Complement and coagulation cascades_Homo sapiens_hsa046101.07400897
42Malaria_Homo sapiens_hsa051441.07026756
43Salmonella infection_Homo sapiens_hsa051321.05795144
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04871478
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04708922
46Focal adhesion_Homo sapiens_hsa045101.04572044
47Sulfur metabolism_Homo sapiens_hsa009201.02816570
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.00830467
49Amoebiasis_Homo sapiens_hsa051461.00150515
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99668111
51Rheumatoid arthritis_Homo sapiens_hsa053230.99576532
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98918340
53ECM-receptor interaction_Homo sapiens_hsa045120.97338746
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.95318171
55Intestinal immune network for IgA production_Homo sapiens_hsa046720.95102162
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93433177
57Shigellosis_Homo sapiens_hsa051310.91225657
58Endocytosis_Homo sapiens_hsa041440.90418027
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.90174166
60African trypanosomiasis_Homo sapiens_hsa051430.87345409
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.86387668
62Toxoplasmosis_Homo sapiens_hsa051450.85157910
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.85009656
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.82402314
65GnRH signaling pathway_Homo sapiens_hsa049120.82173409
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82011403
67Circadian entrainment_Homo sapiens_hsa047130.81961530
68B cell receptor signaling pathway_Homo sapiens_hsa046620.81840301
69Cardiac muscle contraction_Homo sapiens_hsa042600.80030167
70Gastric acid secretion_Homo sapiens_hsa049710.79376736
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79042391
72Insulin resistance_Homo sapiens_hsa049310.78295104
73Mineral absorption_Homo sapiens_hsa049780.78288608
74Cholinergic synapse_Homo sapiens_hsa047250.76531170
75Salivary secretion_Homo sapiens_hsa049700.74148700
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74005511
77Insulin signaling pathway_Homo sapiens_hsa049100.73386066
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73203196
79Hematopoietic cell lineage_Homo sapiens_hsa046400.72945182
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.72103590
81Chemokine signaling pathway_Homo sapiens_hsa040620.71231131
82* Oxytocin signaling pathway_Homo sapiens_hsa049210.70901109
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70378851
84Rap1 signaling pathway_Homo sapiens_hsa040150.69761589
85Legionellosis_Homo sapiens_hsa051340.69460968
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69285627
87VEGF signaling pathway_Homo sapiens_hsa043700.69070855
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68119312
89Renin secretion_Homo sapiens_hsa049240.68031660
90Type II diabetes mellitus_Homo sapiens_hsa049300.67376194
91Glioma_Homo sapiens_hsa052140.67353307
92Oxidative phosphorylation_Homo sapiens_hsa001900.67231305
93Chronic myeloid leukemia_Homo sapiens_hsa052200.66948698
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64784827
95HIF-1 signaling pathway_Homo sapiens_hsa040660.62893308
96Proteoglycans in cancer_Homo sapiens_hsa052050.62581751
97Gap junction_Homo sapiens_hsa045400.62282016
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.61934227
99Pancreatic cancer_Homo sapiens_hsa052120.61931064
100* Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61177750
101Apoptosis_Homo sapiens_hsa042100.61054449
102Galactose metabolism_Homo sapiens_hsa000520.60069640
103cAMP signaling pathway_Homo sapiens_hsa040240.59988595
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58079799
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57805993
106N-Glycan biosynthesis_Homo sapiens_hsa005100.55072527
107Insulin secretion_Homo sapiens_hsa049110.54846509
108Calcium signaling pathway_Homo sapiens_hsa040200.54091842
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.53850363
110Acute myeloid leukemia_Homo sapiens_hsa052210.52674130
111Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52499559
112Morphine addiction_Homo sapiens_hsa050320.52059616
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52031125
114Estrogen signaling pathway_Homo sapiens_hsa049150.51649705
115GABAergic synapse_Homo sapiens_hsa047270.51624847
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51522785
117Renin-angiotensin system_Homo sapiens_hsa046140.51323066
118Pancreatic secretion_Homo sapiens_hsa049720.50883520
119TNF signaling pathway_Homo sapiens_hsa046680.50710199
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49381080
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.49028822
122Influenza A_Homo sapiens_hsa051640.48971312
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47973781
124Protein digestion and absorption_Homo sapiens_hsa049740.47624735
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46730208
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46559945
127Sphingolipid metabolism_Homo sapiens_hsa006000.46540691
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45946134
129Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45344142
130Bladder cancer_Homo sapiens_hsa052190.44692380
131Tryptophan metabolism_Homo sapiens_hsa003800.41758373
132Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39898762
133Glycerolipid metabolism_Homo sapiens_hsa005610.38249024
134Glutamatergic synapse_Homo sapiens_hsa047240.37298205
135Fatty acid biosynthesis_Homo sapiens_hsa000610.36017145
136Cocaine addiction_Homo sapiens_hsa050300.30626913
137Dopaminergic synapse_Homo sapiens_hsa047280.28302949
138Viral myocarditis_Homo sapiens_hsa054160.27748220
139Fatty acid elongation_Homo sapiens_hsa000620.25339831
140Nicotine addiction_Homo sapiens_hsa050330.24802737
141MAPK signaling pathway_Homo sapiens_hsa040100.24245512
142Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.22355535

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