CALU

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)6.33976809
2chondrocyte proliferation (GO:0035988)5.73813103
3protein heterotrimerization (GO:0070208)5.27020973
4endodermal cell differentiation (GO:0035987)4.71862777
5sequestering of extracellular ligand from receptor (GO:0035581)4.42954449
6cell adhesion mediated by integrin (GO:0033627)4.38379479
7bone trabecula formation (GO:0060346)4.25223435
8skin morphogenesis (GO:0043589)4.23478155
9collagen metabolic process (GO:0032963)4.19316642
10neuron projection extension involved in neuron projection guidance (GO:1902284)4.08986426
11axon extension involved in axon guidance (GO:0048846)4.08986426
12collagen catabolic process (GO:0030574)4.08947654
13cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.05328978
14basement membrane organization (GO:0071711)3.96296915
15multicellular organismal macromolecule metabolic process (GO:0044259)3.91425628
16regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.89644095
17peptidyl-proline hydroxylation (GO:0019511)3.84330672
18chondrocyte development (GO:0002063)3.78761453
19COPII vesicle coating (GO:0048208)3.75100993
20multicellular organismal catabolic process (GO:0044243)3.74671091
21multicellular organismal metabolic process (GO:0044236)3.70413844
22extracellular matrix disassembly (GO:0022617)3.67248996
23positive regulation of endothelial cell apoptotic process (GO:2000353)3.66423286
24hippo signaling (GO:0035329)3.63809923
25protein hydroxylation (GO:0018126)3.60739768
26mesenchymal-epithelial cell signaling (GO:0060638)3.60147001
27negative regulation of fatty acid transport (GO:2000192)3.59249214
28endothelial cell morphogenesis (GO:0001886)3.56547766
29negative regulation of chondrocyte differentiation (GO:0032331)3.55972220
30COPI coating of Golgi vesicle (GO:0048205)3.53817551
31Golgi transport vesicle coating (GO:0048200)3.53817551
32epithelial cell-cell adhesion (GO:0090136)3.52329409
33wound healing, spreading of epidermal cells (GO:0035313)3.43655838
34keratan sulfate catabolic process (GO:0042340)3.37610679
35plasma membrane repair (GO:0001778)3.35918374
36type B pancreatic cell proliferation (GO:0044342)3.34122109
37retina vasculature morphogenesis in camera-type eye (GO:0061299)3.34039166
38endocardial cushion development (GO:0003197)3.31817231
39positive regulation of extracellular matrix organization (GO:1903055)3.28780244
40glomerular basement membrane development (GO:0032836)3.28006436
41apoptotic cell clearance (GO:0043277)3.26333375
42cell migration involved in sprouting angiogenesis (GO:0002042)3.25454576
43dermatan sulfate biosynthetic process (GO:0030208)3.25030972
44paraxial mesoderm development (GO:0048339)3.23381195
45maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.20362504
46protein localization to cell surface (GO:0034394)3.20282126
47ventricular cardiac muscle cell development (GO:0055015)3.18365508
48vascular endothelial growth factor signaling pathway (GO:0038084)3.17877102
49positive regulation of epithelial to mesenchymal transition (GO:0010718)3.13301973
50regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.08182947
51metanephric mesenchyme development (GO:0072075)3.07772169
52substrate adhesion-dependent cell spreading (GO:0034446)3.05255787
53cellular response to vitamin (GO:0071295)3.01768037
54notochord development (GO:0030903)3.00174260
55craniofacial suture morphogenesis (GO:0097094)2.99693854
56vesicle coating (GO:0006901)2.98769411
57negative regulation of axon extension involved in axon guidance (GO:0048843)2.98517395
58regulation of SMAD protein import into nucleus (GO:0060390)2.96494837
59extracellular matrix organization (GO:0030198)2.96082508
60renal filtration (GO:0097205)2.95803784
61extracellular structure organization (GO:0043062)2.95164463
62kidney mesenchyme development (GO:0072074)2.94957820
63negative regulation of cartilage development (GO:0061037)2.93909182
64protein retention in ER lumen (GO:0006621)2.92338241
65mesodermal cell differentiation (GO:0048333)2.92170158
66cellular response to vitamin D (GO:0071305)2.91248720
67insulin-like growth factor receptor signaling pathway (GO:0048009)2.90560998
68dermatan sulfate metabolic process (GO:0030205)2.88389780
69G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.88013764
70planar cell polarity pathway involved in neural tube closure (GO:0090179)2.86886039
71wound healing, spreading of cells (GO:0044319)2.85454961
72regulation of tight junction assembly (GO:2000810)2.84890801
73heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.84868170
74nucleotide-sugar biosynthetic process (GO:0009226)2.82056269
75UDP-N-acetylglucosamine metabolic process (GO:0006047)2.80172244
76outer ear morphogenesis (GO:0042473)2.78133689
77glomerular filtration (GO:0003094)2.77169748
78positive regulation of macrophage activation (GO:0043032)2.74737482
79polarized epithelial cell differentiation (GO:0030859)2.74487758
80regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.74383506
81positive regulation of osteoblast proliferation (GO:0033690)2.73446654
82regulation of heart morphogenesis (GO:2000826)2.73443100
83negative regulation of smooth muscle cell migration (GO:0014912)2.72903970
84sprouting angiogenesis (GO:0002040)2.72863241
85regulation of plasminogen activation (GO:0010755)2.72384495
86embryonic skeletal joint morphogenesis (GO:0060272)2.72347673
87positive regulation of cartilage development (GO:0061036)2.70737211
88extracellular fibril organization (GO:0043206)2.70103095
89embryonic cranial skeleton morphogenesis (GO:0048701)2.70048845
90protein maturation by protein folding (GO:0022417)2.69734753
91regulation of cartilage development (GO:0061035)2.68904345
92regulation of transforming growth factor beta2 production (GO:0032909)2.68447112
93positive regulation of blood vessel endothelial cell migration (GO:0043536)2.67552060
94blood vessel maturation (GO:0001955)2.67110567
95regulation of chondrocyte differentiation (GO:0032330)2.65913005
96blood vessel endothelial cell migration (GO:0043534)2.63022615
97muscle cell migration (GO:0014812)2.62590629
98epithelial to mesenchymal transition (GO:0001837)2.62570997
99regulation of integrin-mediated signaling pathway (GO:2001044)2.62556598
100fibril organization (GO:0097435)2.61472658
101positive regulation of mesenchymal cell proliferation (GO:0002053)2.60794106
102extracellular matrix assembly (GO:0085029)2.60632929
103regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.60074607
104cell migration involved in heart development (GO:0060973)2.59168757
105anterior/posterior axis specification, embryo (GO:0008595)2.58378382
106regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.57255353
107positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.55928364
108cellular response to interferon-alpha (GO:0035457)2.54266513
109branching involved in salivary gland morphogenesis (GO:0060445)2.54233823
110positive regulation of SMAD protein import into nucleus (GO:0060391)2.52938820
111cell-substrate junction assembly (GO:0007044)2.51968827
112atrioventricular valve morphogenesis (GO:0003181)2.51524708
113hyaluronan catabolic process (GO:0030214)2.51457839
114hemidesmosome assembly (GO:0031581)2.51390379
115regulation of osteoblast proliferation (GO:0033688)2.51205865
116dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.51013124
117substrate-dependent cell migration (GO:0006929)2.50962994
118wound healing (GO:0042060)2.50859689
119pericardium development (GO:0060039)2.50536017
120negative regulation of stem cell proliferation (GO:2000647)2.49140923
121extracellular regulation of signal transduction (GO:1900115)2.48870880
122extracellular negative regulation of signal transduction (GO:1900116)2.48870880
123negative regulation of axon guidance (GO:1902668)2.47565029
124regulation of mitotic spindle organization (GO:0060236)2.44891973
125midgut development (GO:0007494)2.42496148
126retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.40787744
127lymphangiogenesis (GO:0001946)2.39839522
128positive regulation of protein autophosphorylation (GO:0031954)2.37410752
129negative regulation of BMP signaling pathway (GO:0030514)2.36715521
130negative regulation of osteoblast proliferation (GO:0033689)2.36271797
131negative chemotaxis (GO:0050919)2.34377462
132nuclear pore complex assembly (GO:0051292)2.34302553
133mitotic cytokinesis (GO:0000281)2.34211691

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.45608669
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.95440288
3* RARG_19884340_ChIP-ChIP_MEFs_Mouse4.45138310
4CLOCK_20551151_ChIP-Seq_293T_Human3.83857111
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.39597069
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.30150428
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.20656217
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.19320299
9RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.92190170
10HIF1A_21447827_ChIP-Seq_MCF-7_Human2.75782493
11* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.62529479
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.59196910
13TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.59054653
14CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.51728310
15CJUN_26792858_Chip-Seq_BT549_Human2.48813071
16* WT1_19549856_ChIP-ChIP_CCG9911_Human2.48358658
17BRD4_25478319_ChIP-Seq_HGPS_Human2.40603229
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.38412058
19EP300_21415370_ChIP-Seq_HL-1_Mouse2.16300916
20SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.09855995
21SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.09855995
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.07948063
23ESR1_21235772_ChIP-Seq_MCF-7_Human2.02605151
24AR_21909140_ChIP-Seq_LNCAP_Human2.02233079
25SALL4_18804426_ChIP-ChIP_XEN_Mouse1.93294464
26EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.90750589
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.85333565
28HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.84896396
29WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.83940928
30PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.83897397
31NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.82902614
32PPAR_26484153_Chip-Seq_NCI-H1993_Human1.82154871
33* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.74494850
34ELK1_19687146_ChIP-ChIP_HELA_Human1.71401368
35NRF2_20460467_ChIP-Seq_MEFs_Mouse1.70608142
36NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.70608142
37E2F7_22180533_ChIP-Seq_HELA_Human1.70559875
38* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69845290
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.66090241
40NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.65966245
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.62426824
42ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.61096481
43UBF1/2_26484160_Chip-Seq_HMECs_Human1.58614165
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.57979949
45MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.57848831
46KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57754998
47ATF3_27146783_Chip-Seq_COLON_Human1.54021094
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.53001930
49FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.50829698
50ESR1_15608294_ChIP-ChIP_MCF-7_Human1.50434066
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.50174875
52P300_27058665_Chip-Seq_ZR-75-30cells_Human1.48119005
53SOX17_20123909_ChIP-Seq_XEN_Mouse1.46256727
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.44881531
55JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43742764
56SOX2_20726797_ChIP-Seq_SW620_Human1.40140506
57MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.38037154
58TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37939544
59CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.36283707
60FOXO3_23340844_ChIP-Seq_DLD1_Human1.35927874
61TP53_18474530_ChIP-ChIP_U2OS_Human1.32311773
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31097056
63ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.30598123
64TP53_16413492_ChIP-PET_HCT116_Human1.30394086
65TBX20_22328084_ChIP-Seq_HEART_Mouse1.29965936
66TBX20_22080862_ChIP-Seq_HEART_Mouse1.29965936
67JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29466742
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.28837379
69FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.25607303
70TP53_22127205_ChIP-Seq_IMR90_Human1.24409886
71* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.23608160
72SOX9_24532713_ChIP-Seq_HFSC_Mouse1.20385200
73ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20168595
74SMC1_22415368_ChIP-Seq_MEFs_Mouse1.17343995
75MYC_18555785_ChIP-Seq_MESCs_Mouse1.15902641
76* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.15591929
77GATA4_21415370_ChIP-Seq_HL-1_Mouse1.14657869
78* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11634119
79E2F4_17652178_ChIP-ChIP_JURKAT_Human1.11114444
80EOMES_21245162_ChIP-Seq_HESCs_Human1.10923124
81HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10732832
82TP53_20018659_ChIP-ChIP_R1E_Mouse1.10189533
83SMAD_19615063_ChIP-ChIP_OVARY_Human1.09688787
84TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09419322
85CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07245096
86ESR1_20079471_ChIP-ChIP_T-47D_Human1.07202752
87KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07111457
88MYCN_18555785_ChIP-Seq_MESCs_Mouse1.06297927
89ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05893948
90ISL1_27105846_Chip-Seq_CPCs_Mouse1.05892111
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05551378
92GATA2_21666600_ChIP-Seq_HMVEC_Human1.05241041
93FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.04394454
94KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.04167745
95* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04061017
96ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03994931
97POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03709353
98ELK1_22589737_ChIP-Seq_MCF10A_Human1.03695200
99PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02587586
100NANOG_16153702_ChIP-ChIP_HESCs_Human1.00328923
101UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00261793
102ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00222047
103TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99741177
104NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99189887
105TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98737228
106EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.98318800
107PIAS1_25552417_ChIP-Seq_VCAP_Human0.97653552
108ZNF263_19887448_ChIP-Seq_K562_Human0.96114034
109DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96058600
110TP53_23651856_ChIP-Seq_MEFs_Mouse0.95774976
111SA1_22415368_ChIP-Seq_MEFs_Mouse0.95547742
112* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.95417261
113FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.95176851
114SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.93617302
115RACK7_27058665_Chip-Seq_MCF-7_Human0.93424802
116* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.93149467
117TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92520913
118* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.91919510
119FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.90648016
120* CREB1_15753290_ChIP-ChIP_HEK293T_Human0.89282328
121ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89197651
122* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.84940980
123NFI_21473784_ChIP-Seq_ESCs_Mouse0.83810415
124TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.81645330
125FOXM1_26456572_ChIP-Seq_MCF-7_Human0.80779269
126* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79867056

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.13406180
2MP0005503_abnormal_tendon_morphology4.50998373
3MP0005275_abnormal_skin_tensile4.45109825
4MP0003705_abnormal_hypodermis_morpholog4.13381535
5MP0004272_abnormal_basement_membrane3.28418024
6MP0003279_aneurysm3.14862594
7MP0005623_abnormal_meninges_morphology2.70252582
8MP0006054_spinal_hemorrhage2.58848897
9MP0009384_cardiac_valve_regurgitation2.58625749
10MP0001958_emphysema2.57361464
11MP0003566_abnormal_cell_adhesion2.23638706
12MP0010352_gastrointestinal_tract_polyps2.22658592
13MP0005508_abnormal_skeleton_morphology1.97630287
14MP0010030_abnormal_orbit_morphology1.95824405
15MP0005023_abnormal_wound_healing1.88144866
16MP0002282_abnormal_trachea_morphology1.75641714
17MP0002060_abnormal_skin_morphology1.75406916
18MP0009250_abnormal_appendicular_skeleto1.75288183
19MP0003385_abnormal_body_wall1.63759055
20MP0009053_abnormal_anal_canal1.62989474
21MP0003091_abnormal_cell_migration1.62331734
22MP0009780_abnormal_chondrocyte_physiolo1.59004027
23MP0000537_abnormal_urethra_morphology1.56660245
24MP0010368_abnormal_lymphatic_system1.55951264
25MP0002896_abnormal_bone_mineralization1.54679011
26MP0000733_abnormal_muscle_development1.53299571
27MP0005257_abnormal_intraocular_pressure1.51781189
28MP0004084_abnormal_cardiac_muscle1.47195683
29MP0002295_abnormal_pulmonary_circulatio1.46147178
30MP0004134_abnormal_chest_morphology1.41864455
31MP0002108_abnormal_muscle_morphology1.40852508
32MP0000767_abnormal_smooth_muscle1.36392510
33MP0000163_abnormal_cartilage_morphology1.30842698
34MP0003942_abnormal_urinary_system1.30567869
35MP0001299_abnormal_eye_distance/1.29647338
36MP0001542_abnormal_bone_strength1.25236066
37MP0002115_abnormal_skeleton_extremities1.25070852
38MP0001243_abnormal_dermal_layer1.21895953
39MP0000428_abnormal_craniofacial_morphol1.20982176
40MP0000534_abnormal_ureter_morphology1.20703326
41MP0003115_abnormal_respiratory_system1.17595827
42MP0002933_joint_inflammation1.17388353
43MP0002877_abnormal_melanocyte_morpholog1.15874801
44MP0008932_abnormal_embryonic_tissue1.11323608
45MP0002113_abnormal_skeleton_development1.11054861
46MP0005076_abnormal_cell_differentiation1.10632924
47MP0001879_abnormal_lymphatic_vessel1.09873713
48MP0005390_skeleton_phenotype1.09722973
49MP0003937_abnormal_limbs/digits/tail_de1.08875254
50MP0002932_abnormal_joint_morphology1.08710465
51MP0000751_myopathy1.06473106
52MP0003755_abnormal_palate_morphology1.05972493
53MP0003941_abnormal_skin_development1.05468410
54MP0009697_abnormal_copulation1.03640579
55MP0005408_hypopigmentation1.02830012
56MP0000750_abnormal_muscle_regeneration1.01465312
57MP0002089_abnormal_postnatal_growth/wei0.99798798
58MP0005595_abnormal_vascular_smooth0.99508777
59MP0004197_abnormal_fetal_growth/weight/0.99471427
60MP0005171_absent_coat_pigmentation0.97555841
61MP0003935_abnormal_craniofacial_develop0.97256497
62MP0003283_abnormal_digestive_organ0.96166125
63MP0003567_abnormal_fetal_cardiomyocyte0.96102397
64MP0002128_abnormal_blood_circulation0.95046957
65MP0000013_abnormal_adipose_tissue0.94751814
66MP0000432_abnormal_head_morphology0.93975959
67MP0001915_intracranial_hemorrhage0.93595418
68MP0002109_abnormal_limb_morphology0.92584549
69MP0000762_abnormal_tongue_morphology0.91919652
70MP0003123_paternal_imprinting0.90587307
71MP0002168_other_aberrant_phenotype0.90268372
72MP0006138_congestive_heart_failure0.89403192
73MP0001614_abnormal_blood_vessel0.88436821
74MP0002925_abnormal_cardiovascular_devel0.87572453
75MP0003045_fibrosis0.85460199
76MP0002938_white_spotting0.85150082
77MP0002111_abnormal_tail_morphology0.85115345
78MP0004087_abnormal_muscle_fiber0.84448415
79MP0010630_abnormal_cardiac_muscle0.84059779
80MP0000516_abnormal_urinary_system0.83563987
81MP0005367_renal/urinary_system_phenotyp0.83563987
82MP0004957_abnormal_blastocyst_morpholog0.83519506
83MP0000049_abnormal_middle_ear0.83142955
84MP0003950_abnormal_plasma_membrane0.82700009
85MP0002116_abnormal_craniofacial_bone0.79976992
86MP0000759_abnormal_skeletal_muscle0.78489561
87MP0002084_abnormal_developmental_patter0.78002445
88MP0002233_abnormal_nose_morphology0.76728542
89MP0008775_abnormal_heart_ventricle0.76146059
90MP0003300_gastrointestinal_ulcer0.75875944
91MP0002249_abnormal_larynx_morphology0.75731705
92MP0004233_abnormal_muscle_weight0.75627938
93MP0002085_abnormal_embryonic_tissue0.74589258
94MP0002269_muscular_atrophy0.73997350
95MP0003795_abnormal_bone_structure0.73855574
96MP0001175_abnormal_lung_morphology0.73178869
97MP0008007_abnormal_cellular_replicative0.72680741
98MP0004858_abnormal_nervous_system0.72081288
99MP0002177_abnormal_outer_ear0.71935117
100MP0010234_abnormal_vibrissa_follicle0.71778537
101MP0002998_abnormal_bone_remodeling0.70354184
102MP0002697_abnormal_eye_size0.69790103
103MP0002114_abnormal_axial_skeleton0.69620978
104MP0001849_ear_inflammation0.69059538
105MP0005164_abnormal_response_to0.68818467
106MP0000003_abnormal_adipose_tissue0.68742701
107MP0005165_increased_susceptibility_to0.68627555
108MP0002086_abnormal_extraembryonic_tissu0.68407130
109MP0005193_abnormal_anterior_eye0.67588279
110MP0000266_abnormal_heart_morphology0.67321307
111MP0000749_muscle_degeneration0.66498750
112MP0002088_abnormal_embryonic_growth/wei0.66309494
113MP0001533_abnormal_skeleton_physiology0.66056223
114MP0000467_abnormal_esophagus_morphology0.65894673
115MP0004036_abnormal_muscle_relaxation0.65670894
116MP0003984_embryonic_growth_retardation0.65610000
117MP0001672_abnormal_embryogenesis/_devel0.64220998
118MP0005380_embryogenesis_phenotype0.64220998
119MP0005330_cardiomyopathy0.64046511
120MP0005197_abnormal_uvea_morphology0.63848921
121MP0003448_altered_tumor_morphology0.63135759
122MP0002092_abnormal_eye_morphology0.60443122
123MP0000462_abnormal_digestive_system0.60437387
124MP0005621_abnormal_cell_physiology0.60318108
125MP0000747_muscle_weakness0.59835437

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.14904593
2Premature rupture of membranes (HP:0001788)6.68516267
3Ankle contracture (HP:0006466)4.56595821
4Aortic dissection (HP:0002647)4.31463869
5Cervical subluxation (HP:0003308)4.23326921
6Shallow orbits (HP:0000586)4.20977872
7Soft skin (HP:0000977)3.91388468
8Atrophic scars (HP:0001075)3.82420896
9Aortic aneurysm (HP:0004942)3.80355730
10Neonatal short-limb short stature (HP:0008921)3.79801605
11Broad metatarsal (HP:0001783)3.57334682
12Abnormality of dentin (HP:0010299)3.55980241
13Cerebral aneurysm (HP:0004944)3.49421955
14Bladder diverticulum (HP:0000015)3.43737228
15Peritonitis (HP:0002586)3.41257904
16Dilatation of the ascending aorta (HP:0005111)3.27839201
17Wormian bones (HP:0002645)3.17344813
18Follicular hyperkeratosis (HP:0007502)3.08947398
19Blue sclerae (HP:0000592)3.05071464
20Genu recurvatum (HP:0002816)3.02746738
21Mitral valve prolapse (HP:0001634)3.02303634
22Fragile skin (HP:0001030)3.00739421
23Type 1 muscle fiber predominance (HP:0003803)3.00117203
24Spinal rigidity (HP:0003306)2.93811890
25Increased connective tissue (HP:0009025)2.83501448
26Epiphyseal dysplasia (HP:0002656)2.81531285
27Wrist flexion contracture (HP:0001239)2.80789651
28Vertebral compression fractures (HP:0002953)2.75085646
29Cupped ribs (HP:0000887)2.72173088
30Mesomelia (HP:0003027)2.71498099
31Biconcave vertebral bodies (HP:0004586)2.68877267
32Hypoplastic ischia (HP:0003175)2.67850439
33Vascular tortuosity (HP:0004948)2.63923177
34Abnormality of the acetabulum (HP:0003170)2.57865115
35Osteoarthritis (HP:0002758)2.41129072
36Abnormality of the ischium (HP:0003174)2.40427935
37Bowel diverticulosis (HP:0005222)2.36594771
38Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.30107066
39Elbow flexion contracture (HP:0002987)2.29727257
40Arterial tortuosity (HP:0005116)2.29354461
41Platyspondyly (HP:0000926)2.29274719
42Osteolytic defects of the hand bones (HP:0009699)2.28274372
43Osteolytic defects of the phalanges of the hand (HP:0009771)2.28274372
44Radial bowing (HP:0002986)2.27382366
45Abnormality of the calcaneus (HP:0008364)2.26923276
46Ulnar bowing (HP:0003031)2.24606966
47Coxa vara (HP:0002812)2.24233760
48Hyperextensible skin (HP:0000974)2.23280361
49Mild short stature (HP:0003502)2.23276471
50Wide anterior fontanel (HP:0000260)2.22022343
51Abnormal delivery (HP:0001787)2.21491851
52Aneurysm (HP:0002617)2.20869814
53Joint laxity (HP:0001388)2.19069861
54Broad long bones (HP:0005622)2.18408115
55Overgrowth (HP:0001548)2.15536089
56Mildly elevated creatine phosphokinase (HP:0008180)2.15408998
57Vitreoretinal degeneration (HP:0000655)2.15222207
58Aortic regurgitation (HP:0001659)2.14017967
59Slender build (HP:0001533)2.12949503
60Bell-shaped thorax (HP:0001591)2.12372268
61Deviation of the hallux (HP:0010051)2.09971353
62Cardiovascular calcification (HP:0011915)2.09595422
63Spinal cord lesions (HP:0100561)2.09572675
64Syringomyelia (HP:0003396)2.09572675
65Renal duplication (HP:0000075)2.09131609
66Ectopia lentis (HP:0001083)2.09011826
67Tibial bowing (HP:0002982)2.07499582
68Mitral stenosis (HP:0001718)2.06693224
69Pterygium (HP:0001059)2.06226533
70Flat acetabular roof (HP:0003180)2.06056355
71Nonimmune hydrops fetalis (HP:0001790)2.05357445
72Delayed cranial suture closure (HP:0000270)2.05298964
73Short 4th metacarpal (HP:0010044)2.04770041
74Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.04770041
75Knee flexion contracture (HP:0006380)2.04327799
76Short nail (HP:0001799)2.02520865
77Spinal cord compression (HP:0002176)2.02228829
78Abnormality of the umbilical cord (HP:0010881)2.01596683
79Hallux valgus (HP:0001822)2.00687795
80Thin bony cortex (HP:0002753)2.00606897
81Broad ribs (HP:0000885)2.00282787
82Increased variability in muscle fiber diameter (HP:0003557)1.97642033
83Subacute progressive viral hepatitis (HP:0006572)1.97229726
84Exostoses (HP:0100777)1.96766089
85Scapular winging (HP:0003691)1.94979121
86Spondylolisthesis (HP:0003302)1.94956557
87Disproportionate tall stature (HP:0001519)1.94934362
88Metaphyseal cupping (HP:0003021)1.94131121
89Camptodactyly of toe (HP:0001836)1.93446835
90Protruding ear (HP:0000411)1.92727477
91Delayed closure of the anterior fontanelle (HP:0001476)1.92081771
92Delayed gross motor development (HP:0002194)1.91944786
93Microglossia (HP:0000171)1.90912780
94Absent frontal sinuses (HP:0002688)1.90859721
95Abnormal vertebral ossification (HP:0100569)1.90358870
96Inguinal hernia (HP:0000023)1.90273933
97Infantile muscular hypotonia (HP:0008947)1.89921996
98Hypoplasia of the iris (HP:0007676)1.88795614
99Hip contracture (HP:0003273)1.88377553
100Buphthalmos (HP:0000557)1.87973984
101Broad phalanx (HP:0006009)1.87936426
102Generalized amyotrophy (HP:0003700)1.87615815
103Mitral regurgitation (HP:0001653)1.87054517
104Increased density of long bones (HP:0006392)1.86764733
105Coronal craniosynostosis (HP:0004440)1.86647767
106Bowing of the arm (HP:0006488)1.86254118
107Bowed forearm bones (HP:0003956)1.86254118
108Aortic valve stenosis (HP:0001650)1.85728468
109Abnormality of the peritoneum (HP:0002585)1.84468466
110Natal tooth (HP:0000695)1.84265201
111Limb-girdle muscle weakness (HP:0003325)1.83447458
112Abnormal ossification of hand bones (HP:0005921)1.82286998
113Round ear (HP:0100830)1.82164752
114Asymmetry of the thorax (HP:0001555)1.80854057
115Abnormality of skeletal muscle fiber size (HP:0012084)1.80203476
116Breech presentation (HP:0001623)1.79386006
117Femoral bowing (HP:0002980)1.78275518
118Abnormal umbilical cord blood vessels (HP:0011403)1.77823661
119Single umbilical artery (HP:0001195)1.77823661
120Abnormality of the fetal cardiovascular system (HP:0010948)1.77823661
121Beaking of vertebral bodies (HP:0004568)1.76243257
122Decreased skull ossification (HP:0004331)1.75600849
123Abnormality of the 4th metacarpal (HP:0010012)1.74634570
124Abnormality of carpal bone ossification (HP:0006257)1.74186931
125Distal upper limb amyotrophy (HP:0007149)1.70832195
126Upper limb amyotrophy (HP:0009129)1.70832195
127Reduced subcutaneous adipose tissue (HP:0003758)1.70559729
128Hypoventilation (HP:0002791)1.69262196
129Abnormality of skull ossification (HP:0002703)1.69002865
130Redundant skin (HP:0001582)1.68652352
131Ovoid vertebral bodies (HP:0003300)1.68244448
132Rhizomelia (HP:0008905)1.68063770
133Calcaneovalgus deformity (HP:0001848)1.68017907
134Deformed tarsal bones (HP:0008119)1.67205285
135Entropion (HP:0000621)1.63814891
136Abnormalities of placenta or umbilical cord (HP:0001194)1.60745894

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.90435186
2TTN4.10792603
3TRIB33.57218801
4LATS13.48585746
5PKN23.37163660
6PDGFRA3.02050313
7EIF2AK12.30598593
8NTRK12.14618611
9PBK2.11628829
10LATS22.08405152
11EPHB21.98179345
12SIK11.95003369
13PAK21.93628462
14STK31.83463961
15TRPM71.81522693
16EPHA21.77975893
17EIF2AK31.77973770
18PAK41.63889234
19STK38L1.63245667
20MET1.62960671
21FER1.58925580
22LRRK21.58663876
23RIPK11.57382164
24TGFBR11.55248324
25ERBB31.52572866
26MAP3K121.52353179
27ERN11.52023505
28PTK61.51930756
29WEE11.51094663
30TESK11.45334749
31LIMK11.43880335
32PTK21.41805684
33BUB11.40104403
34PAK31.39322543
35TGFBR21.38981288
36FGFR11.35902481
37NEK91.33706526
38EEF2K1.31698745
39MAP3K31.30739456
40FRK1.29841462
41EPHA31.28211705
42BMX1.25039792
43BCR1.23903013
44FLT31.23385422
45DMPK1.22325214
46RPS6KA41.21071686
47PIK3CA1.19217902
48SCYL21.15647175
49AKT31.12657221
50PDGFRB1.12147498
51TSSK61.12066416
52ROCK11.11710434
53MYLK1.09905765
54PNCK1.04792474
55TRIM281.04498114
56CDK81.04190190
57MUSK1.03520401
58ILK1.00627491
59CLK10.98316648
60NEK10.97234459
61BRSK10.96735364
62NUAK10.95704767
63MTOR0.94001042
64PASK0.92305929
65FGFR20.87661324
66PTK2B0.84992186
67STK100.84440440
68STK380.83070441
69CDK60.80123653
70PRKG20.79200425
71RPS6KB20.76905727
72MAP3K100.76902474
73MOS0.75978566
74LMTK20.74668793
75MST1R0.71991431
76PAK60.71391011
77* PLK30.71230077
78PDK20.70707093
79ROCK20.68909985
80ABL20.68362208
81MAP2K10.67204685
82KDR0.66513727
83STK240.66006923
84MAP3K80.65216350
85PLK40.63514627
86ZAK0.63397233
87PLK10.62959125
88SRPK10.60847935
89CAMK1D0.60255599
90PIM20.58181489
91MKNK20.57914029
92KSR10.57449601
93CHEK20.55252313
94INSR0.53284821
95PDK40.53003087
96PDK30.53003087
97PRKCE0.52538937
98MKNK10.52503696
99BRSK20.52216305
100CDK120.51611456
101TIE10.49243790
102FGFR30.47368794
103MAP2K30.47248332
104CDK180.45903440
105PRKD20.45753146
106MST40.44563009
107ADRBK10.44107821
108NME20.43767821
109EPHB10.42577244
110PRKD10.42510914
111CDC70.41586304
112PAK10.41516940
113PIK3CG0.41437753
114NEK20.41436124
115RET0.41256894
116AURKB0.40099216
117DAPK30.39311932
118CDK150.39078473
119EIF2AK20.38815952
120GRK70.37701062
121CDK140.36424191
122GSK3A0.35979021
123ICK0.35615060
124CDC42BPA0.35419304
125CHEK10.34950839
126ACVR1B0.34929625
127PRKD30.34898028
128IGF1R0.34075871
129DYRK1B0.33385979
130CDK11A0.33308246
131SRC0.32488611
132TTK0.31448390
133ERBB40.30466039
134FGFR40.29181440
135CDK70.29109720
136MELK0.28367050
137ERBB20.27606828
138OBSCN0.23698327
139MAPK10.22939398

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.73096075
2Focal adhesion_Homo sapiens_hsa045103.33918264
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.86941659
4Protein digestion and absorption_Homo sapiens_hsa049742.54058549
5Proteoglycans in cancer_Homo sapiens_hsa052052.51306748
6Adherens junction_Homo sapiens_hsa045202.45371423
7Small cell lung cancer_Homo sapiens_hsa052222.36559827
8Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.27141170
9Protein export_Homo sapiens_hsa030602.25833451
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.25524516
11TGF-beta signaling pathway_Homo sapiens_hsa043502.19595677
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.15148787
13Hippo signaling pathway_Homo sapiens_hsa043902.10631381
14Dilated cardiomyopathy_Homo sapiens_hsa054142.07360547
15Amoebiasis_Homo sapiens_hsa051462.01285757
16MicroRNAs in cancer_Homo sapiens_hsa052061.96810871
17Bladder cancer_Homo sapiens_hsa052191.87992998
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.84901138
19PI3K-Akt signaling pathway_Homo sapiens_hsa041511.74496130
20Basal cell carcinoma_Homo sapiens_hsa052171.74395833
21Malaria_Homo sapiens_hsa051441.68632392
22Proteasome_Homo sapiens_hsa030501.67012106
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.64306583
24Viral myocarditis_Homo sapiens_hsa054161.59578468
25p53 signaling pathway_Homo sapiens_hsa041151.56458931
26Chronic myeloid leukemia_Homo sapiens_hsa052201.51061702
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.40063527
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.37506457
29Tight junction_Homo sapiens_hsa045301.37452938
30Hedgehog signaling pathway_Homo sapiens_hsa043401.33756915
31Melanoma_Homo sapiens_hsa052181.32762739
32Regulation of actin cytoskeleton_Homo sapiens_hsa048101.29251975
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25988695
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21547936
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.18409310
36Cell cycle_Homo sapiens_hsa041101.18250184
37Vibrio cholerae infection_Homo sapiens_hsa051101.15968329
38Prostate cancer_Homo sapiens_hsa052151.15573159
39Pathways in cancer_Homo sapiens_hsa052001.13484871
40Central carbon metabolism in cancer_Homo sapiens_hsa052301.12777967
41Pancreatic cancer_Homo sapiens_hsa052121.10878650
42Vitamin B6 metabolism_Homo sapiens_hsa007501.10207892
43Steroid biosynthesis_Homo sapiens_hsa001001.10168543
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.09345591
45HTLV-I infection_Homo sapiens_hsa051661.07542152
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05674728
47Nucleotide excision repair_Homo sapiens_hsa034201.02547826
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.02131653
49Shigellosis_Homo sapiens_hsa051311.01061267
50Non-homologous end-joining_Homo sapiens_hsa034501.00086743
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98004128
52Sulfur metabolism_Homo sapiens_hsa009200.97246473
53HIF-1 signaling pathway_Homo sapiens_hsa040660.96483060
54Platelet activation_Homo sapiens_hsa046110.95798516
55Toxoplasmosis_Homo sapiens_hsa051450.95751544
56Viral carcinogenesis_Homo sapiens_hsa052030.92682583
57Glutathione metabolism_Homo sapiens_hsa004800.91790028
58Colorectal cancer_Homo sapiens_hsa052100.91032805
59Fatty acid elongation_Homo sapiens_hsa000620.90858774
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89930694
61One carbon pool by folate_Homo sapiens_hsa006700.87648770
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87071765
63N-Glycan biosynthesis_Homo sapiens_hsa005100.86291605
64Rap1 signaling pathway_Homo sapiens_hsa040150.85598149
65Wnt signaling pathway_Homo sapiens_hsa043100.85024757
66Mismatch repair_Homo sapiens_hsa034300.84470883
67Thyroid cancer_Homo sapiens_hsa052160.83645375
68Pyruvate metabolism_Homo sapiens_hsa006200.81308818
69Selenocompound metabolism_Homo sapiens_hsa004500.81253905
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80811996
71Pentose phosphate pathway_Homo sapiens_hsa000300.79792658
72Glioma_Homo sapiens_hsa052140.79700931
73Endometrial cancer_Homo sapiens_hsa052130.77671520
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74003615
75Renal cell carcinoma_Homo sapiens_hsa052110.73904523
76Axon guidance_Homo sapiens_hsa043600.71799193
77Renin-angiotensin system_Homo sapiens_hsa046140.70250721
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69113376
79TNF signaling pathway_Homo sapiens_hsa046680.68384176
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68344545
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.67218623
82DNA replication_Homo sapiens_hsa030300.66673717
83Phagosome_Homo sapiens_hsa041450.66609915
84Apoptosis_Homo sapiens_hsa042100.64512518
85mTOR signaling pathway_Homo sapiens_hsa041500.64236447
86Hepatitis B_Homo sapiens_hsa051610.63885067
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63452227
88Sphingolipid metabolism_Homo sapiens_hsa006000.62091969
89RNA transport_Homo sapiens_hsa030130.62021769
90Basal transcription factors_Homo sapiens_hsa030220.61590235
91Other glycan degradation_Homo sapiens_hsa005110.59162962
92Lysine degradation_Homo sapiens_hsa003100.59156571
93Prion diseases_Homo sapiens_hsa050200.57669583
94Propanoate metabolism_Homo sapiens_hsa006400.57246547
95Notch signaling pathway_Homo sapiens_hsa043300.56054833
96Legionellosis_Homo sapiens_hsa051340.54557164
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53970744
98Ovarian steroidogenesis_Homo sapiens_hsa049130.53101180
99Insulin resistance_Homo sapiens_hsa049310.52660518
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51371241
101AMPK signaling pathway_Homo sapiens_hsa041520.50885521
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50400147
103Melanogenesis_Homo sapiens_hsa049160.49958017
104FoxO signaling pathway_Homo sapiens_hsa040680.46560923
105Salmonella infection_Homo sapiens_hsa051320.44950606
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44819565
107Thyroid hormone synthesis_Homo sapiens_hsa049180.38640903
108Fructose and mannose metabolism_Homo sapiens_hsa000510.37355775
109Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.37295844
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.36806977
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36719599
112Oocyte meiosis_Homo sapiens_hsa041140.35568507
113Folate biosynthesis_Homo sapiens_hsa007900.35223649
114Pyrimidine metabolism_Homo sapiens_hsa002400.35169797
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34451400
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34006315
117Complement and coagulation cascades_Homo sapiens_hsa046100.33811872
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33616553
119Non-small cell lung cancer_Homo sapiens_hsa052230.32954728
120Gap junction_Homo sapiens_hsa045400.32928131
121Lysosome_Homo sapiens_hsa041420.32871953
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.32757449
123Galactose metabolism_Homo sapiens_hsa000520.30910369
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30624358
125Fatty acid metabolism_Homo sapiens_hsa012120.30021984
126VEGF signaling pathway_Homo sapiens_hsa043700.29411935
127Estrogen signaling pathway_Homo sapiens_hsa049150.29322065
128Carbon metabolism_Homo sapiens_hsa012000.28994253
129Ras signaling pathway_Homo sapiens_hsa040140.28743905
130Starch and sucrose metabolism_Homo sapiens_hsa005000.28150998
131Endocytosis_Homo sapiens_hsa041440.27950490
132Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27721689
133Biosynthesis of amino acids_Homo sapiens_hsa012300.25265388
134Arginine and proline metabolism_Homo sapiens_hsa003300.25062584
135Adipocytokine signaling pathway_Homo sapiens_hsa049200.24736207
136Antigen processing and presentation_Homo sapiens_hsa046120.24612440

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