CALR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)7.10489767
2Golgi transport vesicle coating (GO:0048200)7.10489767
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.94171982
4* activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.88365646
5* positive regulation of nuclease activity (GO:0032075)4.82344739
6protein retention in ER lumen (GO:0006621)4.75749947
7* regulation of nuclease activity (GO:0032069)4.38965027
8* endoplasmic reticulum unfolded protein response (GO:0030968)4.30149962
9* cellular response to unfolded protein (GO:0034620)4.10854556
10folic acid-containing compound biosynthetic process (GO:0009396)4.00811406
11* ER-nucleus signaling pathway (GO:0006984)3.92115957
12pentose-phosphate shunt (GO:0006098)3.90236436
134-hydroxyproline metabolic process (GO:0019471)3.84590015
14* cellular response to topologically incorrect protein (GO:0035967)3.83165732
15apoptotic cell clearance (GO:0043277)3.80937268
16retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.77488234
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.72264880
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.72264880
19COPII vesicle coating (GO:0048208)3.58293159
20NADPH regeneration (GO:0006740)3.56942920
21maternal placenta development (GO:0001893)3.54925107
22proline biosynthetic process (GO:0006561)3.54605787
23hemidesmosome assembly (GO:0031581)3.53753860
24mitotic chromosome condensation (GO:0007076)3.40788335
25cell-substrate junction assembly (GO:0007044)3.38847319
26* response to endoplasmic reticulum stress (GO:0034976)3.37616135
27regulation of translational fidelity (GO:0006450)3.33774064
28cytoskeletal anchoring at plasma membrane (GO:0007016)3.32620278
29ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.32040655
30skin morphogenesis (GO:0043589)3.25709626
31antigen processing and presentation of endogenous antigen (GO:0019883)3.19024841
32adherens junction assembly (GO:0034333)3.18794982
33Arp2/3 complex-mediated actin nucleation (GO:0034314)3.18610954
34peptidyl-proline hydroxylation (GO:0019511)3.16695004
35* response to unfolded protein (GO:0006986)3.15484537
36vesicle coating (GO:0006901)3.15403927
37regulation of early endosome to late endosome transport (GO:2000641)3.11361934
38planar cell polarity pathway involved in neural tube closure (GO:0090179)3.11014615
39barbed-end actin filament capping (GO:0051016)3.09279257
40cell-substrate adherens junction assembly (GO:0007045)3.08169760
41focal adhesion assembly (GO:0048041)3.08169760
42mannose metabolic process (GO:0006013)3.05549981
43* response to topologically incorrect protein (GO:0035966)2.98698831
44regulation of mammary gland epithelial cell proliferation (GO:0033599)2.97763052
45DNA unwinding involved in DNA replication (GO:0006268)2.97031729
46positive regulation of histone deacetylation (GO:0031065)2.95626496
47membrane protein ectodomain proteolysis (GO:0006509)2.95015847
48hyaluronan catabolic process (GO:0030214)2.94907273
49negative regulation of fatty acid transport (GO:2000192)2.89320316
50dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.88808935
51protein hydroxylation (GO:0018126)2.86201173
52regulation of glucose import in response to insulin stimulus (GO:2001273)2.86014131
53cell adhesion mediated by integrin (GO:0033627)2.85685216
54pore complex assembly (GO:0046931)2.85562982
55regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.83676056
56* peptidyl-asparagine modification (GO:0018196)2.82342112
57* protein N-linked glycosylation via asparagine (GO:0018279)2.81609549
58nuclear pore complex assembly (GO:0051292)2.78339212
59glucose catabolic process (GO:0006007)2.77779786
60stress fiber assembly (GO:0043149)2.74860883
61regulation of RNA export from nucleus (GO:0046831)2.73164262
62heterochromatin organization (GO:0070828)2.73154709
63peptide catabolic process (GO:0043171)2.72779047
64germ cell migration (GO:0008354)2.70734135
65embryonic process involved in female pregnancy (GO:0060136)2.68699470
66positive regulation of blood vessel endothelial cell migration (GO:0043536)2.67384564
67defense response to fungus (GO:0050832)2.66646443
68tetrahydrofolate metabolic process (GO:0046653)2.64177642
69regulation of nucleobase-containing compound transport (GO:0032239)2.63598714
70antigen processing and presentation via MHC class Ib (GO:0002475)2.63483191
71RNA stabilization (GO:0043489)2.62980267
72mRNA stabilization (GO:0048255)2.62980267
73negative regulation of cell size (GO:0045792)2.62402338
74low-density lipoprotein particle clearance (GO:0034383)2.62119489
75protein localization to endosome (GO:0036010)2.61763967
76protein localization to kinetochore (GO:0034501)2.61741397
77basement membrane organization (GO:0071711)2.59752188
78vascular endothelial growth factor signaling pathway (GO:0038084)2.59395988
79peptidyl-lysine dimethylation (GO:0018027)2.58695770
80negative regulation of phagocytosis (GO:0050765)2.58281407
81nuclear pore organization (GO:0006999)2.57509047
82activation of Rac GTPase activity (GO:0032863)2.57155642
83hypotonic response (GO:0006971)2.56538909
84collagen fibril organization (GO:0030199)2.55863476
85* protein N-linked glycosylation (GO:0006487)2.54727176
86retina vasculature morphogenesis in camera-type eye (GO:0061299)2.54554296
87protein heterotrimerization (GO:0070208)2.54494864
88vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.54118068
89spliceosomal tri-snRNP complex assembly (GO:0000244)2.53955777
90endodermal cell differentiation (GO:0035987)2.53478884
91multicellular organismal macromolecule metabolic process (GO:0044259)2.52943235
92L-alpha-amino acid transmembrane transport (GO:1902475)2.51971231
93collagen catabolic process (GO:0030574)2.51308921
94endothelial cell chemotaxis (GO:0035767)2.50758258
95mitotic nuclear envelope disassembly (GO:0007077)2.49148292
96desmosome organization (GO:0002934)2.48550347
97killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.48023061
98disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.48023061
99response to fungus (GO:0009620)2.47781156
100extracellular matrix disassembly (GO:0022617)2.47258729
101glucose 6-phosphate metabolic process (GO:0051156)2.46409649
102UDP-N-acetylglucosamine metabolic process (GO:0006047)2.45878794
103wound healing, spreading of epidermal cells (GO:0035313)2.43881274
104semaphorin-plexin signaling pathway (GO:0071526)2.43297321
105positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.43166816
106endothelial cell morphogenesis (GO:0001886)2.43132423
107regulation of translational termination (GO:0006449)2.41442366
108branching involved in mammary gland duct morphogenesis (GO:0060444)2.41166896
109UV protection (GO:0009650)2.40930426
110regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.40764121
111nuclear envelope disassembly (GO:0051081)2.39461014
112membrane disassembly (GO:0030397)2.39461014
113nucleobase-containing small molecule interconversion (GO:0015949)2.38730889
114positive regulation of endothelial cell apoptotic process (GO:2000353)2.38035639
115dosage compensation (GO:0007549)2.37860177
116cellular response to vitamin D (GO:0071305)2.37210356
117cellular protein complex localization (GO:0034629)2.36664906
118regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.36361087
119establishment of apical/basal cell polarity (GO:0035089)2.36012286
120cellular copper ion homeostasis (GO:0006878)2.35769812
121surfactant homeostasis (GO:0043129)2.35635221
122multicellular organismal metabolic process (GO:0044236)2.34465199
123actin nucleation (GO:0045010)2.33722040
124platelet degranulation (GO:0002576)2.32267274
125epithelial cell-cell adhesion (GO:0090136)2.31732250
126positive regulation of osteoblast proliferation (GO:0033690)2.30310020
127IMP biosynthetic process (GO:0006188)2.30246795
128regulation of protein heterodimerization activity (GO:0043497)2.29710133
129protein complex localization (GO:0031503)2.29622576
130organ regeneration (GO:0031100)2.29468129
131apoptotic process involved in morphogenesis (GO:0060561)2.29427960
132multicellular organismal catabolic process (GO:0044243)2.28844772
133wound healing, spreading of cells (GO:0044319)2.28806262
134epithelial cell differentiation involved in prostate gland development (GO:0060742)2.28675622
135positive regulation of SMAD protein import into nucleus (GO:0060391)2.28406831
136* sequestering of metal ion (GO:0051238)2.28317749
137regulation of fatty acid beta-oxidation (GO:0031998)2.25322081
138cellular response to vitamin (GO:0071295)2.24836151
139T cell apoptotic process (GO:0070231)2.23387844
140collagen metabolic process (GO:0032963)2.22195702
141positive regulation of protein deacetylation (GO:0090312)2.21511132
142keratan sulfate catabolic process (GO:0042340)2.21331705
143positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.21223468
144pinocytosis (GO:0006907)2.20933994
145IMP metabolic process (GO:0046040)2.20062242
146blood vessel endothelial cell migration (GO:0043534)2.19765501
147negative regulation of fibrinolysis (GO:0051918)2.17779831
148exocrine pancreas development (GO:0031017)2.16937012
149protein autoprocessing (GO:0016540)2.15727493
150protein carboxylation (GO:0018214)2.15542828
151peptidyl-glutamic acid carboxylation (GO:0017187)2.15542828
152receptor catabolic process (GO:0032801)2.15121830

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.94858405
2* EGR1_19374776_ChIP-ChIP_THP-1_Human3.34363450
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.30406261
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.09354421
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.82031580
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.80297431
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.68365467
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.62521373
9* MYC_22102868_ChIP-Seq_BL_Human2.58278776
10* CLOCK_20551151_ChIP-Seq_293T_Human2.54585555
11* VDR_21846776_ChIP-Seq_THP-1_Human2.25566210
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.22325826
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.09006016
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.03847054
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.95464565
16PPARA_22158963_ChIP-Seq_LIVER_Mouse1.91544877
17* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88686871
18AR_21909140_ChIP-Seq_LNCAP_Human1.85933476
19RXR_22158963_ChIP-Seq_LIVER_Mouse1.77847387
20* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.77720384
21BRD4_27068464_Chip-Seq_AML-cells_Mouse1.76541083
22ELK3_25401928_ChIP-Seq_HUVEC_Human1.76173470
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73838651
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.73512849
25* MYC_18555785_ChIP-Seq_MESCs_Mouse1.70619246
26TRIM28_21343339_ChIP-Seq_HEK293_Human1.64777660
27KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.62983618
28TCF7_22412390_ChIP-Seq_EML_Mouse1.60089260
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.58918739
30RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.58058058
31ESR1_15608294_ChIP-ChIP_MCF-7_Human1.57813556
32* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.53992773
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.53236103
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.52084905
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52032188
36MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49953878
37* VDR_24763502_ChIP-Seq_THP-1_Human1.49880992
38ATF3_27146783_Chip-Seq_COLON_Human1.48537792
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47755827
40SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.47182500
41* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.46387184
42POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.44800557
43E2F4_17652178_ChIP-ChIP_JURKAT_Human1.44631574
44KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.44548197
45WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40036699
46* TFEB_21752829_ChIP-Seq_HELA_Human1.39638398
47TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38023794
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.37136741
49CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.37083194
50* UTX_26944678_Chip-Seq_JUKART_Human1.37030347
51RACK7_27058665_Chip-Seq_MCF-7_Human1.35362298
52MAF_26560356_Chip-Seq_TH1_Human1.34716149
53TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34555777
54LXR_22292898_ChIP-Seq_THP-1_Human1.33974839
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33685005
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.32700790
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32247982
58* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.32084777
59LXR_22158963_ChIP-Seq_LIVER_Mouse1.31379666
60P300_27058665_Chip-Seq_ZR-75-30cells_Human1.30831439
61KDM2B_26808549_Chip-Seq_DND41_Human1.30549974
62ESR2_21235772_ChIP-Seq_MCF-7_Human1.30273607
63* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28246500
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28148676
65* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.28117399
66* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27605936
67HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27371264
68MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26905963
69ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.26337246
70* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.22185183
71ZNF263_19887448_ChIP-Seq_K562_Human1.21965532
72NCOR1_26117541_ChIP-Seq_K562_Human1.21598180
73TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19368855
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19230207
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19220631
76CHD1_26751641_Chip-Seq_LNCaP_Human1.17351316
77* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16745770
78* RUNX1_22412390_ChIP-Seq_EML_Mouse1.16526203
79KDM2B_26808549_Chip-Seq_K562_Human1.15974648
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15703276
81SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15455606
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15036424
83GATA6_25053715_ChIP-Seq_YYC3_Human1.14445332
84SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.14401310
85* XRN2_22483619_ChIP-Seq_HELA_Human1.14060525
86EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14008465
87PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13904557
88ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12851931
89TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11959023
90KDM5A_27292631_Chip-Seq_BREAST_Human1.11708202
91NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10958428
92TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10069598
93FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.09134241
94IRF8_22096565_ChIP-ChIP_GC-B_Human1.08432668
95SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08401997
96GATA1_22025678_ChIP-Seq_K562_Human1.08389495
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07536987
98SPI1_23547873_ChIP-Seq_NB4_Human1.07373294
99MYB_26560356_Chip-Seq_TH1_Human1.07337954
100* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06145557
101* MYB_26560356_Chip-Seq_TH2_Human1.05805415
102KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05568512
103TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05416791
104* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05337964
105GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05003386
106HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03998202
107RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02518298
108TP53_22127205_ChIP-Seq_IMR90_Human1.02082879
109SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02075896
110TET1_21451524_ChIP-Seq_MESCs_Mouse1.01562111
111UBF1/2_26484160_Chip-Seq_HMECs_Human1.01025254
112TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00625573
113* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.00455671
114CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98514882
115CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98040128
116E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97573024
117SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96848576
118SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96848576
119IRF8_27001747_Chip-Seq_BMDM_Mouse0.96177345
120EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.95001351
121KDM2B_26808549_Chip-Seq_JURKAT_Human0.94363065
122SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.93550277
123NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93281839
124SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92039679
125SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91981969
126TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91717979
127FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91542425
128MYCN_18555785_ChIP-Seq_MESCs_Mouse0.90467563
129CIITA_25753668_ChIP-Seq_RAJI_Human0.88870951

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.27577519
2MP0003705_abnormal_hypodermis_morpholog3.89967357
3MP0003300_gastrointestinal_ulcer3.03345116
4MP0010352_gastrointestinal_tract_polyps2.93336189
5MP0006054_spinal_hemorrhage2.89811278
6MP0002877_abnormal_melanocyte_morpholog2.70150938
7MP0003303_peritoneal_inflammation2.52857849
8MP0005076_abnormal_cell_differentiation2.45824120
9MP0005451_abnormal_body_composition2.37836330
10MP0005275_abnormal_skin_tensile2.17960814
11* MP0003566_abnormal_cell_adhesion2.13984889
12MP0010234_abnormal_vibrissa_follicle2.08413827
13MP0005058_abnormal_lysosome_morphology1.90177915
14MP0004858_abnormal_nervous_system1.85515641
15MP0010307_abnormal_tumor_latency1.85019140
16MP0005023_abnormal_wound_healing1.78702450
17MP0004233_abnormal_muscle_weight1.76647710
18MP0003693_abnormal_embryo_hatching1.65698588
19MP0004272_abnormal_basement_membrane1.65083445
20MP0003172_abnormal_lysosome_physiology1.61272279
21MP0001958_emphysema1.56987995
22MP0010368_abnormal_lymphatic_system1.56712659
23MP0009840_abnormal_foam_cell1.45812973
24MP0004264_abnormal_extraembryonic_tissu1.42935549
25MP0009384_cardiac_valve_regurgitation1.38872853
26MP0009053_abnormal_anal_canal1.36353981
27MP0003941_abnormal_skin_development1.32779506
28MP0003279_aneurysm1.30886515
29MP0005409_darkened_coat_color1.30179316
30MP0004957_abnormal_blastocyst_morpholog1.28766963
31MP0003436_decreased_susceptibility_to1.28287679
32MP0005503_abnormal_tendon_morphology1.27315384
33MP0005220_abnormal_exocrine_pancreas1.25708577
34MP0002796_impaired_skin_barrier1.23759522
35MP0002139_abnormal_hepatobiliary_system1.23330053
36MP0005360_urolithiasis1.23271892
37MP0005623_abnormal_meninges_morphology1.21917107
38MP0002060_abnormal_skin_morphology1.21875297
39MP0003950_abnormal_plasma_membrane1.20928339
40MP0002896_abnormal_bone_mineralization1.19127982
41MP0003252_abnormal_bile_duct1.18151673
42MP0003183_abnormal_peptide_metabolism1.16234028
43MP0005501_abnormal_skin_physiology1.16104713
44MP0002396_abnormal_hematopoietic_system1.14937562
45MP0000858_altered_metastatic_potential1.14364522
46MP0004808_abnormal_hematopoietic_stem1.13208842
47MP0001533_abnormal_skeleton_physiology1.11911526
48MP0003283_abnormal_digestive_organ1.10203624
49MP0001348_abnormal_lacrimal_gland1.09159843
50MP0005464_abnormal_platelet_physiology1.07080179
51MP0002166_altered_tumor_susceptibility1.06850058
52MP0000537_abnormal_urethra_morphology1.06173969
53MP0004197_abnormal_fetal_growth/weight/1.05885174
54MP0001730_embryonic_growth_arrest1.05422128
55MP0003191_abnormal_cellular_cholesterol1.05233443
56MP0001915_intracranial_hemorrhage1.04986213
57MP0000733_abnormal_muscle_development1.04958082
58MP0008260_abnormal_autophagy1.04879528
59MP0010030_abnormal_orbit_morphology1.03739246
60MP0001849_ear_inflammation1.02897098
61MP0009278_abnormal_bone_marrow1.02764579
62MP0000465_gastrointestinal_hemorrhage1.02682332
63MP0004782_abnormal_surfactant_physiolog1.02308017
64MP0003329_amyloid_beta_deposits1.01313298
65MP0008932_abnormal_embryonic_tissue1.00408420
66MP0004185_abnormal_adipocyte_glucose0.97246917
67MP0001216_abnormal_epidermal_layer0.96694168
68MP0004947_skin_inflammation0.94691570
69MP0001661_extended_life_span0.94204364
70MP0002086_abnormal_extraembryonic_tissu0.93706625
71MP0009643_abnormal_urine_homeostasis0.93129359
72* MP0003091_abnormal_cell_migration0.91937064
73MP0000762_abnormal_tongue_morphology0.87583609
74MP0000490_abnormal_crypts_of0.87345365
75MP0005197_abnormal_uvea_morphology0.87150317
76MP0003111_abnormal_nucleus_morphology0.86536270
77MP0000350_abnormal_cell_proliferation0.85375875
78MP0000598_abnormal_liver_morphology0.84804962
79MP0001243_abnormal_dermal_layer0.84428728
80MP0005165_increased_susceptibility_to0.83845920
81MP0003795_abnormal_bone_structure0.82350948
82MP0000678_abnormal_parathyroid_gland0.82224471
83MP0005257_abnormal_intraocular_pressure0.82106291
84MP0003448_altered_tumor_morphology0.81486613
85MP0002088_abnormal_embryonic_growth/wei0.81423305
86MP0000428_abnormal_craniofacial_morphol0.81350351
87MP0003984_embryonic_growth_retardation0.80672851
88MP0005365_abnormal_bile_salt0.79779319
89MP0000609_abnormal_liver_physiology0.79581492
90MP0008007_abnormal_cellular_replicative0.79082385
91* MP0002080_prenatal_lethality0.78199202
92MP0001944_abnormal_pancreas_morphology0.78145924
93MP0005083_abnormal_biliary_tract0.77432249
94MP0000003_abnormal_adipose_tissue0.76926109
95MP0001542_abnormal_bone_strength0.76663087
96MP0000747_muscle_weakness0.76408690
97MP0005375_adipose_tissue_phenotype0.75865638
98MP0000534_abnormal_ureter_morphology0.75641404
99MP0000013_abnormal_adipose_tissue0.75403459
100MP0003123_paternal_imprinting0.75233223
101MP0001697_abnormal_embryo_size0.75230658
102MP0005390_skeleton_phenotype0.75115117
103* MP0005384_cellular_phenotype0.74925018
104MP0009931_abnormal_skin_appearance0.74708322
105MP0000627_abnormal_mammary_gland0.74584979
106MP0002419_abnormal_innate_immunity0.74457700
107MP0009672_abnormal_birth_weight0.74358191
108MP0001614_abnormal_blood_vessel0.74204262
109MP0003077_abnormal_cell_cycle0.73834068
110MP0005380_embryogenesis_phenotype0.73136993
111MP0001672_abnormal_embryogenesis/_devel0.73136993
112MP0000467_abnormal_esophagus_morphology0.72904320
113MP0000604_amyloidosis0.72091204
114MP0003315_abnormal_perineum_morphology0.71717478
115MP0001666_abnormal_nutrient_absorption0.71517253
116MP0005508_abnormal_skeleton_morphology0.70621583
117MP0003942_abnormal_urinary_system0.70616394
118* MP0002085_abnormal_embryonic_tissue0.70542488
119MP0002084_abnormal_developmental_patter0.70204346
120MP0003045_fibrosis0.70170856
121MP0010155_abnormal_intestine_physiology0.69843820
122MP0002295_abnormal_pulmonary_circulatio0.69645790
123MP0003453_abnormal_keratinocyte_physiol0.69624382
124MP0001545_abnormal_hematopoietic_system0.68547059
125MP0005397_hematopoietic_system_phenotyp0.68547059
126MP0000767_abnormal_smooth_muscle0.67899826
127MP0000477_abnormal_intestine_morphology0.67646685
128MP0001845_abnormal_inflammatory_respons0.67587027
129MP0010329_abnormal_lipoprotein_level0.67550371
130MP0002135_abnormal_kidney_morphology0.67382464
131MP0002089_abnormal_postnatal_growth/wei0.65527364
132MP0005319_abnormal_enzyme/_coenzyme0.64394139
133MP0003115_abnormal_respiratory_system0.64341615
134* MP0005621_abnormal_cell_physiology0.64001186

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.91375278
2Premature rupture of membranes (HP:0001788)4.53963758
3Cerebral aneurysm (HP:0004944)3.92302426
4Cervical subluxation (HP:0003308)3.71437169
5Ankle contracture (HP:0006466)3.29798975
6Peritonitis (HP:0002586)3.16411909
7Shallow orbits (HP:0000586)3.13064118
8Mucopolysacchariduria (HP:0008155)2.91099180
9Urinary glycosaminoglycan excretion (HP:0003541)2.91099180
10Aortic dissection (HP:0002647)2.85535189
11Aortic aneurysm (HP:0004942)2.81262345
12Flat acetabular roof (HP:0003180)2.75970397
13Hand muscle atrophy (HP:0009130)2.73815624
14Short nail (HP:0001799)2.70169033
15Dysostosis multiplex (HP:0000943)2.68222521
16Arterial tortuosity (HP:0005116)2.67233257
17Vascular tortuosity (HP:0004948)2.65263235
18Dilatation of the ascending aorta (HP:0005111)2.59253614
19Bladder diverticulum (HP:0000015)2.56173410
20Distal upper limb amyotrophy (HP:0007149)2.54508698
21Upper limb amyotrophy (HP:0009129)2.54508698
22Abnormality of glycosaminoglycan metabolism (HP:0004371)2.54498938
23Abnormality of mucopolysaccharide metabolism (HP:0011020)2.54498938
24Abnormality of polysaccharide metabolism (HP:0011012)2.54498938
25Aneurysm (HP:0002617)2.50572948
26Mitral valve prolapse (HP:0001634)2.49993360
27Increased density of long bones (HP:0006392)2.47008558
28Back pain (HP:0003418)2.44331842
29Atrophic scars (HP:0001075)2.43564899
30Osteolytic defects of the phalanges of the hand (HP:0009771)2.38063485
31Osteolytic defects of the hand bones (HP:0009699)2.38063485
32Genu recurvatum (HP:0002816)2.37883296
33Broad face (HP:0000283)2.33287645
34Spinal rigidity (HP:0003306)2.33167912
35Disproportionate tall stature (HP:0001519)2.31065451
36Blue sclerae (HP:0000592)2.29702968
37Asymmetry of the thorax (HP:0001555)2.28731634
38Soft skin (HP:0000977)2.26824217
39Severe short stature (HP:0003510)2.26011678
40Insomnia (HP:0100785)2.22885040
41Thoracolumbar scoliosis (HP:0002944)2.22016237
42Thin bony cortex (HP:0002753)2.21709690
43Abnormality of the intrinsic pathway (HP:0010989)2.20668883
44Increased mean platelet volume (HP:0011877)2.20412326
45Abnormality of carpal bone ossification (HP:0006257)2.18124928
46Ulnar bowing (HP:0003031)2.17940670
47Spastic diplegia (HP:0001264)2.17507047
48Ankyloglossia (HP:0010296)2.17179334
49Subacute progressive viral hepatitis (HP:0006572)2.17050854
50Natal tooth (HP:0000695)2.16325750
51Deep venous thrombosis (HP:0002625)2.15502127
52Vertebral compression fractures (HP:0002953)2.15098661
53Abnormality of the common coagulation pathway (HP:0010990)2.14544587
54Bowel diverticulosis (HP:0005222)2.13432700
55Abnormality of the acetabulum (HP:0003170)2.12390256
56Abnormal platelet volume (HP:0011876)2.11192730
57Radial bowing (HP:0002986)2.09314965
58Abnormal ossification of hand bones (HP:0005921)2.08402978
59Nonimmune hydrops fetalis (HP:0001790)2.06902983
60Distal lower limb amyotrophy (HP:0008944)2.06322759
61Hematochezia (HP:0002573)2.04959674
62Wormian bones (HP:0002645)2.03830934
63Abnormality of the peritoneum (HP:0002585)2.03688664
64Hyperacusis (HP:0010780)2.03588825
65Abnormal delivery (HP:0001787)2.01121946
66Neonatal short-limb short stature (HP:0008921)1.98846385
67Fragile skin (HP:0001030)1.96449684
68Abnormality of the calcaneus (HP:0008364)1.96289754
69Trismus (HP:0000211)1.95613613
70Renal duplication (HP:0000075)1.95269155
71Myocardial infarction (HP:0001658)1.94461639
72Mitral regurgitation (HP:0001653)1.93949898
73Advanced eruption of teeth (HP:0006288)1.93223002
74Vacuolated lymphocytes (HP:0001922)1.92835865
75Breech presentation (HP:0001623)1.92625250
76Hallux valgus (HP:0001822)1.91115642
77Joint laxity (HP:0001388)1.90826763
78Long palpebral fissure (HP:0000637)1.90722237
79Abnormality of glycolipid metabolism (HP:0010969)1.90571267
80Abnormality of liposaccharide metabolism (HP:0010968)1.90571267
81Abnormality of glycosphingolipid metabolism (HP:0004343)1.90571267
82Deviation of the hallux (HP:0010051)1.89746225
83Hyperextensible skin (HP:0000974)1.89090244
84Lymphangioma (HP:0100764)1.84700794
85Achilles tendon contracture (HP:0001771)1.83804669
86High pitched voice (HP:0001620)1.83224837
87Abnormality of the Achilles tendon (HP:0005109)1.83041600
88Rectal prolapse (HP:0002035)1.82424372
89Interstitial pulmonary disease (HP:0006530)1.82414482
90Hypoglycemic coma (HP:0001325)1.82281849
91Cerebral inclusion bodies (HP:0100314)1.79584662
92Spondylolisthesis (HP:0003302)1.78258061
93Bowed forearm bones (HP:0003956)1.78098823
94Bowing of the arm (HP:0006488)1.78098823
95Abnormality of the distal phalanx of the thumb (HP:0009617)1.77613376
96Distal lower limb muscle weakness (HP:0009053)1.77231182
97Coxa vara (HP:0002812)1.76880151
98Patellar dislocation (HP:0002999)1.76622999
99Long toe (HP:0010511)1.76488801
100Increased cerebral lipofuscin (HP:0011813)1.76326387
101Selective tooth agenesis (HP:0001592)1.75889600
102Beaking of vertebral bodies (HP:0004568)1.74974515
103Papilledema (HP:0001085)1.72986059
104Syringomyelia (HP:0003396)1.72694208
105Spinal cord lesions (HP:0100561)1.72694208
106Abnormality of the thoracic spine (HP:0100711)1.72615948
107Mitral stenosis (HP:0001718)1.72615394
108Orthostatic hypotension (HP:0001278)1.72444842
109Enlarged penis (HP:0000040)1.72155152
110Cupped ribs (HP:0000887)1.71745558
111Hemorrhage of the eye (HP:0011885)1.71492079
112Insidious onset (HP:0003587)1.71165685
113Termporal pattern (HP:0011008)1.71165685
114Sparse lateral eyebrow (HP:0005338)1.71140212
115Mildly elevated creatine phosphokinase (HP:0008180)1.69976047
116Elbow flexion contracture (HP:0002987)1.69734809
117Delayed cranial suture closure (HP:0000270)1.68977561
118Slender build (HP:0001533)1.68746218
119Exostoses (HP:0100777)1.68453174
120Platyspondyly (HP:0000926)1.68342268
121Generalized amyotrophy (HP:0003700)1.68226907
122Persistence of primary teeth (HP:0006335)1.67812316
123Increased connective tissue (HP:0009025)1.67701092
124Biconcave vertebral bodies (HP:0004586)1.67579204
125Missing ribs (HP:0000921)1.67196766
126Premature skin wrinkling (HP:0100678)1.66208499
127Abnormality of dentin (HP:0010299)1.65987271
128Deviation of the thumb (HP:0009603)1.63915486
129Abnormality of monocarboxylic acid metabolism (HP:0010996)1.63828950
130Broad metatarsal (HP:0001783)1.63213379
131Metaphyseal cupping (HP:0003021)1.62815004
132Eczematoid dermatitis (HP:0000976)1.62352459
133Centrally nucleated skeletal muscle fibers (HP:0003687)1.61611389
134Increased variability in muscle fiber diameter (HP:0003557)1.61326316
135Abnormality of the distal phalanges of the toes (HP:0010182)1.61310345
136Spinal cord compression (HP:0002176)1.61198740
137Ectopia lentis (HP:0001083)1.61091693
138Relative macrocephaly (HP:0004482)1.60883000
139Upper motor neuron abnormality (HP:0002127)1.60763315
140Follicular hyperkeratosis (HP:0007502)1.60653501
141Flattened epiphyses (HP:0003071)1.60607043
142Abnormality of the lumbar spine (HP:0100712)1.60134297
143Xanthomatosis (HP:0000991)1.60064954
144Slender long bone (HP:0003100)1.57084653
145Joint stiffness (HP:0001387)1.56957336
146Tibial bowing (HP:0002982)1.56879595
147Abnormality of the odontoid process (HP:0003310)1.55429200
148Abnormal cartilage morphology (HP:0002763)1.55285896
149Cutaneous melanoma (HP:0012056)1.55242585
150Abnormal foot bone ossification (HP:0010675)1.54951355
151Abnormality of oral frenula (HP:0000190)1.54223052
152Ulnar deviation of the wrist (HP:0003049)1.53737155
153Camptodactyly of toe (HP:0001836)1.51524683

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.66080191
2ERN14.34068903
3PKN23.91638869
4SMG13.49339529
5EEF2K3.28472913
6ICK3.12879876
7SCYL22.90651892
8IRAK32.68882328
9TAOK32.33539391
10PTK62.25191088
11TTN2.24022084
12NME22.10758488
13LRRK22.09832809
14PDGFRA2.07440336
15MAP3K102.00873487
16LATS21.95457531
17RIPK11.87108271
18PRPF4B1.86726749
19TESK11.83687779
20STK101.79628851
21PASK1.78893315
22PAK41.78561172
23NTRK11.78440682
24FLT31.72004468
25TESK21.65267644
26SIK11.55894145
27DDR21.43088172
28CDK121.40287013
29PAK21.32541210
30MAP3K81.31962378
31NEK21.24861361
32CDC71.23896594
33BMX1.23717252
34RPS6KB21.21078515
35RPS6KA41.18322665
36ARAF1.17197091
37EPHB11.14713061
38ALK1.12467938
39LATS11.12292427
40MOS1.08387580
41EPHA21.06516534
42PTK21.04928144
43FRK1.00719930
44MTOR1.00105475
45STK30.94724533
46FGFR40.93483481
47CDK60.92773557
48ERBB40.92439292
49MAP2K30.91972547
50NEK10.91639985
51TAOK20.91136029
52TGFBR10.88359643
53LMTK20.88170932
54EIF2AK10.86348914
55BTK0.82073903
56EPHB20.81213276
57BRSK20.80277413
58CAMK1D0.79778013
59MAP3K130.77632023
60MET0.76210678
61ILK0.76008507
62TRPM70.75219330
63MAPKAPK30.74911772
64CLK10.73516941
65TBK10.71755078
66JAK30.71448269
67CDK40.71127894
68KSR20.71116678
69FER0.70583724
70PDGFRB0.70119291
71TYK20.68670595
72MAP3K140.67781399
73PRKD20.67644046
74WEE10.67470741
75PIM20.66727385
76NEK90.66610261
77MAP4K10.65653250
78ZAP700.65174131
79CDC42BPA0.64885060
80BCKDK0.64841569
81BRAF0.63681361
82BLK0.63450306
83MAPK110.62768915
84KDR0.62002547
85RET0.61970078
86TGFBR20.61739155
87DYRK1B0.60969431
88JAK10.60275875
89KIT0.58825063
90LIMK10.58164967
91CSK0.57436431
92JAK20.56998508
93PBK0.56276991
94EIF2AK30.55827255
95EPHA30.55773469
96MAP3K30.53933653
97CSF1R0.52877285
98DMPK0.52700665
99CDK80.52634655
100CDK90.52349495
101ITK0.51839035
102AURKA0.51317758
103TSSK60.50941234
104HIPK20.50279675
105PRKG20.50191119
106CDK70.50020405
107CHEK20.48265358
108RPS6KA20.48012250
109AURKB0.47563231
110BUB10.47474260
111CHEK10.46988339
112PRKD30.46912472
113PDPK10.46817643
114PIK3CG0.46720173
115PAK10.46720156
116BRD40.46172609
117MAP2K20.46169440
118MYLK0.45084031
119MAP3K10.44540161
120FGFR10.44262484
121MAP3K20.42107344
122MAP3K60.41739484
123EGFR0.40790081
124ATR0.40366818
125ABL20.40324320
126AKT20.39882739
127GRK60.39016010
128CAMK1G0.38851330
129PIM10.38608043
130ROCK20.38470580
131MST1R0.37130638
132TAOK10.37048838
133TTK0.36211915
134FGFR30.36030259
135GSK3A0.35054236
136CDK150.32921028
137MATK0.32285969
138HCK0.31890626
139MAPKAPK20.31869344
140CAMKK10.31606187
141RPS6KC10.31469204

Predicted pathways (KEGG)

RankGene SetZ-score
1* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.35486583
2N-Glycan biosynthesis_Homo sapiens_hsa005102.27590579
3One carbon pool by folate_Homo sapiens_hsa006702.16069739
4Glycosaminoglycan degradation_Homo sapiens_hsa005311.98289759
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.87593972
6Selenocompound metabolism_Homo sapiens_hsa004501.84452881
7Maturity onset diabetes of the young_Homo sapiens_hsa049501.73525042
8Protein export_Homo sapiens_hsa030601.66921984
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.64793530
10* Antigen processing and presentation_Homo sapiens_hsa046121.64751704
11Lysosome_Homo sapiens_hsa041421.63118656
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.56963734
13Chronic myeloid leukemia_Homo sapiens_hsa052201.54992235
14Other glycan degradation_Homo sapiens_hsa005111.54556049
15ECM-receptor interaction_Homo sapiens_hsa045121.51701458
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.51658082
17Small cell lung cancer_Homo sapiens_hsa052221.49038555
18Bladder cancer_Homo sapiens_hsa052191.47286117
19Renin-angiotensin system_Homo sapiens_hsa046141.45558270
20Focal adhesion_Homo sapiens_hsa045101.43294684
21Fructose and mannose metabolism_Homo sapiens_hsa000511.40882780
22Amoebiasis_Homo sapiens_hsa051461.30204256
23Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29177249
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27972348
25Nitrogen metabolism_Homo sapiens_hsa009101.25706886
26Proteoglycans in cancer_Homo sapiens_hsa052051.23142717
27DNA replication_Homo sapiens_hsa030301.20189349
28Vibrio cholerae infection_Homo sapiens_hsa051101.19540737
29Lysine degradation_Homo sapiens_hsa003101.19192151
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.18893654
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.17668672
32Legionellosis_Homo sapiens_hsa051341.13316055
33Central carbon metabolism in cancer_Homo sapiens_hsa052301.11677549
34Viral carcinogenesis_Homo sapiens_hsa052031.10356758
35Endometrial cancer_Homo sapiens_hsa052131.09232191
36Renal cell carcinoma_Homo sapiens_hsa052111.08864076
37Pentose phosphate pathway_Homo sapiens_hsa000301.06090752
38Thyroid hormone synthesis_Homo sapiens_hsa049181.05943329
39Leishmaniasis_Homo sapiens_hsa051401.05855063
40Complement and coagulation cascades_Homo sapiens_hsa046101.04184481
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03283281
42Biosynthesis of amino acids_Homo sapiens_hsa012301.00801669
43Galactose metabolism_Homo sapiens_hsa000520.98127391
44Toxoplasmosis_Homo sapiens_hsa051450.96857917
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96763608
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95568909
47Pancreatic cancer_Homo sapiens_hsa052120.94672916
48Insulin resistance_Homo sapiens_hsa049310.93662955
49Notch signaling pathway_Homo sapiens_hsa043300.93321383
50Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93055908
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91979769
52Apoptosis_Homo sapiens_hsa042100.91772299
53Sulfur metabolism_Homo sapiens_hsa009200.90887811
54MicroRNAs in cancer_Homo sapiens_hsa052060.90455913
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90005931
56Starch and sucrose metabolism_Homo sapiens_hsa005000.88800226
57Adherens junction_Homo sapiens_hsa045200.88789262
58Staphylococcus aureus infection_Homo sapiens_hsa051500.88224052
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.87696200
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85913900
61Protein digestion and absorption_Homo sapiens_hsa049740.85878413
62Thyroid cancer_Homo sapiens_hsa052160.85733544
63mTOR signaling pathway_Homo sapiens_hsa041500.84933501
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83779544
65Shigellosis_Homo sapiens_hsa051310.83758064
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82693481
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82432763
68Salmonella infection_Homo sapiens_hsa051320.81343263
69Carbon metabolism_Homo sapiens_hsa012000.78109864
70Fatty acid degradation_Homo sapiens_hsa000710.77900887
71Cell cycle_Homo sapiens_hsa041100.77040630
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75864104
73Osteoclast differentiation_Homo sapiens_hsa043800.75771960
74Tryptophan metabolism_Homo sapiens_hsa003800.74158023
75p53 signaling pathway_Homo sapiens_hsa041150.73979845
76Prostate cancer_Homo sapiens_hsa052150.73795478
77Acute myeloid leukemia_Homo sapiens_hsa052210.73089361
78RNA transport_Homo sapiens_hsa030130.72271894
79Systemic lupus erythematosus_Homo sapiens_hsa053220.72131375
80ErbB signaling pathway_Homo sapiens_hsa040120.70536384
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.70389071
82Pathways in cancer_Homo sapiens_hsa052000.69530100
83Insulin signaling pathway_Homo sapiens_hsa049100.68568044
84Caffeine metabolism_Homo sapiens_hsa002320.68093594
85Platelet activation_Homo sapiens_hsa046110.68053443
86Sulfur relay system_Homo sapiens_hsa041220.67313524
87Colorectal cancer_Homo sapiens_hsa052100.67275868
88Non-small cell lung cancer_Homo sapiens_hsa052230.66635638
89Fat digestion and absorption_Homo sapiens_hsa049750.66287387
90Hepatitis B_Homo sapiens_hsa051610.66226223
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.65884871
92Arginine biosynthesis_Homo sapiens_hsa002200.65442653
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64806299
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64647176
95Hepatitis C_Homo sapiens_hsa051600.63441945
96Melanoma_Homo sapiens_hsa052180.63279469
97Fatty acid biosynthesis_Homo sapiens_hsa000610.63000019
98Sphingolipid metabolism_Homo sapiens_hsa006000.61596993
99mRNA surveillance pathway_Homo sapiens_hsa030150.61055073
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.60485091
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.60204608
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59987221
103Spliceosome_Homo sapiens_hsa030400.59309666
104Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58333519
105AMPK signaling pathway_Homo sapiens_hsa041520.57570725
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56955540
107Pertussis_Homo sapiens_hsa051330.56472113
108Endocytosis_Homo sapiens_hsa041440.55093731
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54572886
110* HTLV-I infection_Homo sapiens_hsa051660.54530137
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53927743
112Glioma_Homo sapiens_hsa052140.53606947
113Prion diseases_Homo sapiens_hsa050200.52468172
114B cell receptor signaling pathway_Homo sapiens_hsa046620.50598300
115Hippo signaling pathway_Homo sapiens_hsa043900.49923387
116HIF-1 signaling pathway_Homo sapiens_hsa040660.49861359
117Viral myocarditis_Homo sapiens_hsa054160.49248425
118TNF signaling pathway_Homo sapiens_hsa046680.49064219
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.48802403
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48315468
121Estrogen signaling pathway_Homo sapiens_hsa049150.47931976
122VEGF signaling pathway_Homo sapiens_hsa043700.47669770
123Malaria_Homo sapiens_hsa051440.47584161
124TGF-beta signaling pathway_Homo sapiens_hsa043500.47457649
125Prolactin signaling pathway_Homo sapiens_hsa049170.47434838
126Base excision repair_Homo sapiens_hsa034100.47304301
127* Phagosome_Homo sapiens_hsa041450.47278590
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.47182038
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46134333
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46052946
131Vitamin B6 metabolism_Homo sapiens_hsa007500.45952321
132Nucleotide excision repair_Homo sapiens_hsa034200.43849509
133Influenza A_Homo sapiens_hsa051640.43342142
134Tight junction_Homo sapiens_hsa045300.40821828
135Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40478496

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