CALM1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.89364557
2oxidative demethylation (GO:0070989)5.53755159
3alkaloid metabolic process (GO:0009820)5.41666783
4dicarboxylic acid catabolic process (GO:0043649)5.40305402
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.38516470
6ATP synthesis coupled proton transport (GO:0015986)5.07435166
7energy coupled proton transport, down electrochemical gradient (GO:0015985)5.07435166
8inositol phosphate-mediated signaling (GO:0048016)4.96977681
9neurofilament cytoskeleton organization (GO:0060052)4.86997231
10protein polyglutamylation (GO:0018095)4.48676640
11DNA damage response, detection of DNA damage (GO:0042769)4.33485564
12response to pheromone (GO:0019236)4.31979712
13drug catabolic process (GO:0042737)4.17291475
14negative regulation of norepinephrine secretion (GO:0010700)4.16668103
15protein complex biogenesis (GO:0070271)4.16624834
16negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.02755063
17axoneme assembly (GO:0035082)3.90936687
18negative regulation of heart rate (GO:0010459)3.87821009
19substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.81227236
20substrate-independent telencephalic tangential migration (GO:0021826)3.81227236
21retinal cone cell development (GO:0046549)3.80437630
22regulation of uterine smooth muscle contraction (GO:0070472)3.72217852
23sarcoplasmic reticulum calcium ion transport (GO:0070296)3.67706649
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.51973981
25mitochondrial respiratory chain complex assembly (GO:0033108)3.51829124
26respiratory electron transport chain (GO:0022904)3.50129961
27hydrogen ion transmembrane transport (GO:1902600)3.45405357
28electron transport chain (GO:0022900)3.43352135
29cornea development in camera-type eye (GO:0061303)3.41926265
30neutrophil mediated immunity (GO:0002446)3.41497702
31protein neddylation (GO:0045116)3.29060037
32positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.27694730
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.24601523
34negative regulation of adenylate cyclase activity (GO:0007194)3.23744830
35positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.20671506
36terpenoid biosynthetic process (GO:0016114)3.19953592
37proton transport (GO:0015992)3.16745140
38ATP biosynthetic process (GO:0006754)3.15479245
39hydrogen transport (GO:0006818)3.10108461
40regulation of cellular respiration (GO:0043457)3.08868784
41cell proliferation in forebrain (GO:0021846)3.08495036
42negative regulation of cyclase activity (GO:0031280)3.06195357
43protein localization to cilium (GO:0061512)3.03757574
44retinal ganglion cell axon guidance (GO:0031290)3.02032586
45negative regulation of lyase activity (GO:0051350)3.01918226
46negative regulation of catecholamine secretion (GO:0033604)3.01251513
47ubiquinone biosynthetic process (GO:0006744)3.00110727
48purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.99778170
49ubiquinone metabolic process (GO:0006743)2.98341935
50negative regulation of meiotic cell cycle (GO:0051447)2.97670312
51gamma-aminobutyric acid signaling pathway (GO:0007214)2.96838439
52peroxisome fission (GO:0016559)2.94852379
53purine nucleoside triphosphate biosynthetic process (GO:0009145)2.94507498
54myeloid leukocyte mediated immunity (GO:0002444)2.94061747
55regulation of calcium ion-dependent exocytosis (GO:0017158)2.92436044
56DNA double-strand break processing (GO:0000729)2.91422479
57L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.88012713
58regulation of meiosis I (GO:0060631)2.87472247
59synaptic transmission, cholinergic (GO:0007271)2.87391677
60receptor recycling (GO:0001881)2.86990881
61exploration behavior (GO:0035640)2.80601150
62negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.78833851
63negative regulation of calcium ion transmembrane transport (GO:1903170)2.78833851
64nonmotile primary cilium assembly (GO:0035058)2.75857206
65response to redox state (GO:0051775)2.71765852
66circadian sleep/wake cycle process (GO:0022410)2.68432867
67short-term memory (GO:0007614)2.68023304
68detection of calcium ion (GO:0005513)2.66629475
69primary amino compound metabolic process (GO:1901160)2.64088109
70protein-cofactor linkage (GO:0018065)2.63237939
71isoprenoid biosynthetic process (GO:0008299)2.62380508
72negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.62210733
73activation of protein kinase B activity (GO:0032148)2.62163109
74mitochondrial respiratory chain complex I assembly (GO:0032981)2.59286337
75NADH dehydrogenase complex assembly (GO:0010257)2.59286337
76mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.59286337
77artery smooth muscle contraction (GO:0014824)2.57587935
78negative regulation of cAMP biosynthetic process (GO:0030818)2.56424502
79diterpenoid biosynthetic process (GO:0016102)2.55845826
80genetic imprinting (GO:0071514)2.55696769
81DNA methylation involved in gamete generation (GO:0043046)2.55369646
82protein heterotetramerization (GO:0051290)2.53483644
83positive regulation of potassium ion transport (GO:0043268)2.53231853
844-hydroxyproline metabolic process (GO:0019471)2.52259687
85GTP biosynthetic process (GO:0006183)2.50058100
86regulation of axon regeneration (GO:0048679)2.49124994
87regulation of neuron projection regeneration (GO:0070570)2.49124994
88ribonucleoside triphosphate biosynthetic process (GO:0009201)2.49102476
89fear response (GO:0042596)2.49077572
90negative regulation of purine nucleotide biosynthetic process (GO:1900372)2.45978110
91negative regulation of nucleotide biosynthetic process (GO:0030809)2.45978110
92negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)2.45366157
93energy homeostasis (GO:0097009)2.45084679
94calcium ion import (GO:0070509)2.44980494
95L-methionine salvage (GO:0071267)2.44864013
96L-methionine biosynthetic process (GO:0071265)2.44864013
97amino acid salvage (GO:0043102)2.44864013
98negative regulation of cAMP metabolic process (GO:0030815)2.42371085
99adrenergic receptor signaling pathway (GO:0071875)2.40383358
100sterol biosynthetic process (GO:0016126)2.40272754

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.32911231
2EZH2_22144423_ChIP-Seq_EOC_Human3.49057652
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.05474263
4CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.98091630
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.74113737
6VDR_22108803_ChIP-Seq_LS180_Human2.72774273
7IGF1R_20145208_ChIP-Seq_DFB_Human2.65116970
8ZNF274_21170338_ChIP-Seq_K562_Hela2.59156141
9GBX2_23144817_ChIP-Seq_PC3_Human2.39005819
10TAF15_26573619_Chip-Seq_HEK293_Human2.29182777
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.26641259
12TP53_22573176_ChIP-Seq_HFKS_Human2.14449242
13REST_21632747_ChIP-Seq_MESCs_Mouse2.06041467
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.00855119
15EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.96223260
16CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80993449
17TRIM28_21343339_ChIP-Seq_HEK293_Human1.80443200
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.77957495
19BCAT_22108803_ChIP-Seq_LS180_Human1.66678249
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.65192203
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64741419
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63821745
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59709227
24FUS_26573619_Chip-Seq_HEK293_Human1.54098715
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53082475
26P300_19829295_ChIP-Seq_ESCs_Human1.52661863
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.49842541
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49313373
29FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.48086314
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.46010622
31EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.45609703
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.44991084
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.44831438
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.44307404
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43674235
36TCF4_22108803_ChIP-Seq_LS180_Human1.43270198
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42932342
38CBP_20019798_ChIP-Seq_JUKART_Human1.42932342
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39322817
40AHR_22903824_ChIP-Seq_MCF-7_Human1.37738539
41SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35031759
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.34438745
43ER_23166858_ChIP-Seq_MCF-7_Human1.32872400
44P53_22127205_ChIP-Seq_FIBROBLAST_Human1.32061872
45AR_21572438_ChIP-Seq_LNCaP_Human1.31816183
46AR_25329375_ChIP-Seq_VCAP_Human1.31598380
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30241804
48RUNX2_22187159_ChIP-Seq_PCA_Human1.29754563
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29452793
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28638481
51EST1_17652178_ChIP-ChIP_JURKAT_Human1.28513111
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28390276
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26589276
54SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.21501966
55SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.20746382
56SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20417574
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19852011
58SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16515795
59KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16203548
60AR_20517297_ChIP-Seq_VCAP_Human1.15314916
61STAT3_23295773_ChIP-Seq_U87_Human1.15101162
62SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.15046650
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14792557
64ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12838508
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12630171
66EED_16625203_ChIP-ChIP_MESCs_Mouse1.11991880
67TCF4_23295773_ChIP-Seq_U87_Human1.11933297
68FLI1_21867929_ChIP-Seq_TH2_Mouse1.11672514
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11086050
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.10610394
71SMAD4_21799915_ChIP-Seq_A2780_Human1.09795909
72SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.09377019
73CDX2_22108803_ChIP-Seq_LS180_Human1.06601602
74NANOG_19829295_ChIP-Seq_ESCs_Human1.06469130
75SOX2_19829295_ChIP-Seq_ESCs_Human1.06469130
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06359879
77FOXA1_25329375_ChIP-Seq_VCAP_Human1.06359879
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.05150233
79IRF1_19129219_ChIP-ChIP_H3396_Human1.03832559
80KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02849479
81ELK1_19687146_ChIP-ChIP_HELA_Human1.02136611
82FOXH1_21741376_ChIP-Seq_EPCs_Human1.00732620
83CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00715956
84RNF2_27304074_Chip-Seq_ESCs_Mouse1.00511463
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99584547
86TDRD3_21172665_ChIP-Seq_MCF-7_Human0.99315740
87SMAD3_21741376_ChIP-Seq_ESCs_Human0.99024289
88SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98938335
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98820956
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94739379
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94739379
92GATA3_21878914_ChIP-Seq_MCF-7_Human0.94648104
93RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94477398
94RNF2_27304074_Chip-Seq_NSC_Mouse0.93801677
95CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.93767934
96MTF2_20144788_ChIP-Seq_MESCs_Mouse0.93389097
97LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93131357
98JARID2_20075857_ChIP-Seq_MESCs_Mouse0.92839978
99NCOR_22424771_ChIP-Seq_293T_Human0.92309049
100PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.92151781

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.83278540
2MP0003195_calcinosis5.11382507
3MP0002163_abnormal_gland_morphology4.08903998
4MP0003787_abnormal_imprinting4.01353094
5MP0004145_abnormal_muscle_electrophysio3.30813696
6MP0000569_abnormal_digit_pigmentation2.82890022
7MP0001986_abnormal_taste_sensitivity2.71461477
8MP0003123_paternal_imprinting2.67756243
9MP0006292_abnormal_olfactory_placode2.66727006
10MP0009046_muscle_twitch2.63034333
11MP0001501_abnormal_sleep_pattern2.62324545
12MP0005379_endocrine/exocrine_gland_phen2.59413517
13MP0005423_abnormal_somatic_nervous2.47924005
14MP0008877_abnormal_DNA_methylation2.47832892
15MP0001984_abnormal_olfaction2.19607099
16MP0001440_abnormal_grooming_behavior2.08817679
17MP0006082_CNS_inflammation2.07453146
18MP0003122_maternal_imprinting2.06620634
19MP0002272_abnormal_nervous_system2.01448460
20MP0001970_abnormal_pain_threshold1.83171987
21MP0003121_genomic_imprinting1.69084400
22MP0009745_abnormal_behavioral_response1.65727586
23MP0004142_abnormal_muscle_tone1.64073061
24MP0008875_abnormal_xenobiotic_pharmacok1.56544597
25MP0002837_dystrophic_cardiac_calcinosis1.53728329
26MP0002572_abnormal_emotion/affect_behav1.51307401
27MP0003635_abnormal_synaptic_transmissio1.46474289
28MP0002234_abnormal_pharynx_morphology1.45506690
29MP0003011_delayed_dark_adaptation1.45486824
30MP0008872_abnormal_physiological_respon1.42906100
31MP0004043_abnormal_pH_regulation1.42383561
32MP0005645_abnormal_hypothalamus_physiol1.40681106
33MP0000013_abnormal_adipose_tissue1.38926666
34MP0002734_abnormal_mechanical_nocicepti1.35350451
35MP0001968_abnormal_touch/_nociception1.34468332
36MP0002063_abnormal_learning/memory/cond1.33334729
37MP0004742_abnormal_vestibular_system1.26687463
38MP0002557_abnormal_social/conspecific_i1.25196873
39MP0002064_seizures1.24352091
40MP0010386_abnormal_urinary_bladder1.22213735
41MP0003136_yellow_coat_color1.22192251
42MP0002638_abnormal_pupillary_reflex1.22037957
43MP0005332_abnormal_amino_acid1.22012387
44MP0003186_abnormal_redox_activity1.21119518
45MP0001919_abnormal_reproductive_system1.19721260
46MP0006035_abnormal_mitochondrial_morpho1.19111165
47MP0005551_abnormal_eye_electrophysiolog1.17048094
48MP0003880_abnormal_central_pattern1.14585207
49MP0002733_abnormal_thermal_nociception1.12093354
50MP0002876_abnormal_thyroid_physiology1.10281590
51MP0002653_abnormal_ependyma_morphology1.10194865
52MP0000631_abnormal_neuroendocrine_gland1.09437049
53MP0004924_abnormal_behavior1.06476778
54MP0005386_behavior/neurological_phenoty1.06476778
55MP0002067_abnormal_sensory_capabilities1.04207495
56MP0002909_abnormal_adrenal_gland0.99492072
57MP0004484_altered_response_of0.96119394
58MP0009780_abnormal_chondrocyte_physiolo0.95150802
59MP0003633_abnormal_nervous_system0.94495922
60MP0006276_abnormal_autonomic_nervous0.92851751
61MP0005646_abnormal_pituitary_gland0.91640801
62MP0004085_abnormal_heartbeat0.91528176
63MP0001270_distended_abdomen0.89243897
64MP0005084_abnormal_gallbladder_morpholo0.87726227
65MP0000538_abnormal_urinary_bladder0.87212843
66MP0006072_abnormal_retinal_apoptosis0.87165627
67MP0001756_abnormal_urination0.86335884
68MP0001348_abnormal_lacrimal_gland0.85435983
69MP0001486_abnormal_startle_reflex0.84552214
70MP0000015_abnormal_ear_pigmentation0.84342934
71MP0002735_abnormal_chemical_nociception0.82562209
72MP0002736_abnormal_nociception_after0.80579532
73MP0003879_abnormal_hair_cell0.80211711
74MP0004019_abnormal_vitamin_homeostasis0.80102609
75MP0005085_abnormal_gallbladder_physiolo0.79529725
76MP0000230_abnormal_systemic_arterial0.79196359
77MP0009379_abnormal_foot_pigmentation0.79016286
78MP0005389_reproductive_system_phenotype0.77536740
79MP0002295_abnormal_pulmonary_circulatio0.77136240
80MP0002160_abnormal_reproductive_system0.75536794
81MP0000639_abnormal_adrenal_gland0.74951862
82MP0002184_abnormal_innervation0.74428494
83MP0001765_abnormal_ion_homeostasis0.73790841
84MP0001529_abnormal_vocalization0.70714467
85MP0000685_abnormal_immune_system0.70650458
86MP0003631_nervous_system_phenotype0.70443003
87MP0002938_white_spotting0.69004799
88MP0010329_abnormal_lipoprotein_level0.68500172
89MP0003646_muscle_fatigue0.68357185
90MP0005253_abnormal_eye_physiology0.67579416
91MP0004885_abnormal_endolymph0.67525848
92MP0002229_neurodegeneration0.65794592
93MP0002882_abnormal_neuron_morphology0.65777400
94MP0001905_abnormal_dopamine_level0.64404705
95MP0004811_abnormal_neuron_physiology0.63984534
96MP0004859_abnormal_synaptic_plasticity0.60665793
97MP0005174_abnormal_tail_pigmentation0.60543520
98MP0003938_abnormal_ear_development0.59690423
99MP0000955_abnormal_spinal_cord0.58582102
100MP0008789_abnormal_olfactory_epithelium0.56919948

Predicted human phenotypes

RankGene SetZ-score
1Broad alveolar ridges (HP:0000187)5.81655165
2Myokymia (HP:0002411)5.59736846
3Limb dystonia (HP:0002451)4.92861873
4Febrile seizures (HP:0002373)3.76392288
5Abnormal mitochondria in muscle tissue (HP:0008316)3.67694243
6Action tremor (HP:0002345)3.64135785
7Progressive cerebellar ataxia (HP:0002073)3.49936934
8Decreased activity of mitochondrial respiratory chain (HP:0008972)3.43908132
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.43908132
10Atonic seizures (HP:0010819)3.34729009
11Acute necrotizing encephalopathy (HP:0006965)3.26175826
12Type II lissencephaly (HP:0007260)3.23543498
13Focal seizures (HP:0007359)3.21987291
14Neoplasm of the adrenal cortex (HP:0100641)3.06351117
15Mitochondrial inheritance (HP:0001427)3.03796104
16Increased CSF lactate (HP:0002490)3.02680326
17Hepatic necrosis (HP:0002605)2.91255813
18Abnormality of the alveolar ridges (HP:0006477)2.86954410
19Dysdiadochokinesis (HP:0002075)2.83717331
20Abnormal tarsal ossification (HP:0008369)2.81827658
21Hepatocellular necrosis (HP:0001404)2.81243365
22Stenosis of the external auditory canal (HP:0000402)2.78576942
23Neonatal hypoglycemia (HP:0001998)2.77620889
24Acute encephalopathy (HP:0006846)2.77237565
25Abnormality of the corticospinal tract (HP:0002492)2.76564392
26Medial flaring of the eyebrow (HP:0010747)2.75708662
27Lissencephaly (HP:0001339)2.72377425
28Abnormal pancreas size (HP:0012094)2.71370889
29Focal motor seizures (HP:0011153)2.71062215
30Progressive macrocephaly (HP:0004481)2.62255212
31Increased intramyocellular lipid droplets (HP:0012240)2.61974886
32Severe visual impairment (HP:0001141)2.57068942
33Renal cortical cysts (HP:0000803)2.50776368
34Pancreatic cysts (HP:0001737)2.42644029
35Molar tooth sign on MRI (HP:0002419)2.38449836
36Abnormality of midbrain morphology (HP:0002418)2.38449836
37Absence seizures (HP:0002121)2.37822479
38X-linked dominant inheritance (HP:0001423)2.37492102
39Abnormality of magnesium homeostasis (HP:0004921)2.37042004
403-Methylglutaconic aciduria (HP:0003535)2.36692702
41Renal dysplasia (HP:0000110)2.36601931
42Retinal dysplasia (HP:0007973)2.34779900
43Hypomagnesemia (HP:0002917)2.32725552
44Broad-based gait (HP:0002136)2.31803113
45EEG with generalized epileptiform discharges (HP:0011198)2.29837869
46Hypsarrhythmia (HP:0002521)2.28937059
47Epileptiform EEG discharges (HP:0011182)2.27687704
48Abnormality of alanine metabolism (HP:0010916)2.26556084
49Hyperalaninemia (HP:0003348)2.26556084
50Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.26556084
51Epileptic encephalopathy (HP:0200134)2.26374155
52Generalized aminoaciduria (HP:0002909)2.23389565
53Congenital, generalized hypertrichosis (HP:0004540)2.22271670
54Increased serum lactate (HP:0002151)2.18379536
55Parakeratosis (HP:0001036)2.17607005
56Optic disc pallor (HP:0000543)2.16214616
57Spastic tetraplegia (HP:0002510)2.15734439
58Gaze-evoked nystagmus (HP:0000640)2.14461953
59Diastasis recti (HP:0001540)2.14235996
60Large eyes (HP:0001090)2.12030082
61Degeneration of the lateral corticospinal tracts (HP:0002314)2.10432821
62Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.10432821
63Increased muscle lipid content (HP:0009058)2.10228265
64Increased hepatocellular lipid droplets (HP:0006565)2.08359520
65Hepatoblastoma (HP:0002884)2.07828431
66Pachygyria (HP:0001302)2.04819452
67Abnormality of renal resorption (HP:0011038)2.04281161
68Adrenal hypoplasia (HP:0000835)2.03227672
69Abnormality of urine glucose concentration (HP:0011016)2.03203738
70Glycosuria (HP:0003076)2.03203738
71Tetraplegia (HP:0002445)2.02845855
72Neoplasm of the adrenal gland (HP:0100631)2.02273956
73Metaphyseal dysplasia (HP:0100255)2.01506788
74Erythroderma (HP:0001019)2.01189123
75Gait imbalance (HP:0002141)2.00904827
76Drooling (HP:0002307)1.98414435
77Mutism (HP:0002300)1.97924548
78Nephronophthisis (HP:0000090)1.97401148
79Lipid accumulation in hepatocytes (HP:0006561)1.95762476
80Abnormality of the renal cortex (HP:0011035)1.95328137
81Absent rod-and cone-mediated responses on ERG (HP:0007688)1.93319611
82Dialeptic seizures (HP:0011146)1.92612937
83Renal Fanconi syndrome (HP:0001994)1.91946155
84Impaired vibration sensation in the lower limbs (HP:0002166)1.91235634
85Severe muscular hypotonia (HP:0006829)1.91015520
86Abnormal rod and cone electroretinograms (HP:0008323)1.88608320
87Aplasia/hypoplasia of the uterus (HP:0008684)1.88455953
88Hypothermia (HP:0002045)1.88088273
89Abnormal drinking behavior (HP:0030082)1.85674074
90Polydipsia (HP:0001959)1.85674074
91Congenital stationary night blindness (HP:0007642)1.83319394
92Overlapping toe (HP:0001845)1.82525154
93Exocrine pancreatic insufficiency (HP:0001738)1.82510624
94Cerebellar dysplasia (HP:0007033)1.81951597
95Elevated erythrocyte sedimentation rate (HP:0003565)1.81276122
96Excessive salivation (HP:0003781)1.81128492
97Lactic acidosis (HP:0003128)1.80295635
98Intellectual disability, moderate (HP:0002342)1.78247314
99Type I transferrin isoform profile (HP:0003642)1.77328648
100Congenital primary aphakia (HP:0007707)1.76466300

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKD37.22772481
2BMPR1B4.22162123
3MAP3K123.81622019
4CASK3.63177258
5CAMKK23.42137918
6CDK83.09736509
7BCR2.49443632
8ZAK2.00729797
9LIMK11.97136039
10TNIK1.88914645
11TESK11.80346292
12GRK11.79720332
13FRK1.74150635
14MAP4K21.69546624
15PDK21.64161812
16ADRBK21.49600836
17TXK1.44038781
18FLT31.34120893
19MYLK1.32904623
20PHKG11.32795003
21PHKG21.32795003
22TGFBR11.26509841
23CDK191.25215044
24PKN21.24985639
25WNK41.23108496
26ADRBK11.20946282
27PLK21.17197111
28TIE11.01266106
29MARK11.00692569
30MST40.94146095
31PRKCE0.93001543
32PKN10.89543084
33PINK10.86279224
34CAMK2A0.86141870
35NUAK10.85898672
36TAOK30.84411716
37CSNK1G30.83031509
38DYRK20.81994386
39PRKCG0.79765497
40EIF2AK30.76548653
41ERN10.75709444
42PNCK0.75422227
43CSNK1G20.75080766
44EIF2AK10.74180865
45OXSR10.72941096
46CAMKK10.69951871
47PAK40.69152273
48DAPK30.67999824
49CSNK1A1L0.66137459
50PRKG10.61270931
51TRIM280.60519448
52ITK0.59716296
53ROCK10.59143788
54AKT20.58189864
55MST1R0.57023974
56MINK10.56572553
57CSNK1G10.56331421
58PAK10.55291782
59ARAF0.55216199
60MAPK130.54698912
61WNK30.51799797
62PRKCI0.49723985
63PAK30.49268515
64ABL20.47605131
65INSRR0.47444172
66PRKCA0.47257256
67IRAK30.46000487
68GRK50.44584831
69RPS6KA20.44534946
70ILK0.42863948
71UHMK10.41267323
72PRKACA0.40891853
73CDK90.40312664
74PRKCD0.40220962
75DAPK20.40091062
76CAMK1G0.40037837
77CHEK20.39993384
78EPHB20.38939590
79GRK60.38830156
80CSNK1A10.38006689
81CAMK40.37682296
82WNK10.37051323
83HIPK20.35394317
84PTK20.34987812
85CDK50.34806559
86CLK10.34546914
87CAMK10.34429798
88MAP3K40.32366153
89CSNK1E0.31974845
90MKNK20.31351297
91STK38L0.31180023
92TAF10.31094859
93ERBB20.30690988
94LATS10.30635911
95CAMK2D0.28770974
96ROCK20.28441920
97NTRK20.27437366
98PIK3CA0.26627887
99VRK10.26215467
100RPS6KA60.25527828

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.88872071
2Nitrogen metabolism_Homo sapiens_hsa009103.66872715
3Protein export_Homo sapiens_hsa030603.48186363
4Parkinsons disease_Homo sapiens_hsa050123.43213952
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.89614148
6Cardiac muscle contraction_Homo sapiens_hsa042602.81986878
7Alzheimers disease_Homo sapiens_hsa050102.60719671
8Nicotine addiction_Homo sapiens_hsa050332.43408977
9GABAergic synapse_Homo sapiens_hsa047272.13053014
10Huntingtons disease_Homo sapiens_hsa050161.99327560
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.94090558
12Taste transduction_Homo sapiens_hsa047421.84318234
13Retinol metabolism_Homo sapiens_hsa008301.84288974
14Steroid biosynthesis_Homo sapiens_hsa001001.83359760
15Chemical carcinogenesis_Homo sapiens_hsa052041.67901264
16Morphine addiction_Homo sapiens_hsa050321.66999367
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.66094113
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.63243172
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.61777037
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.59557908
21Folate biosynthesis_Homo sapiens_hsa007901.58213433
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.55270317
23Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.54422914
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.53150501
25Circadian entrainment_Homo sapiens_hsa047131.45340196
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44782425
27Ribosome_Homo sapiens_hsa030101.44175385
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.36768909
29Butanoate metabolism_Homo sapiens_hsa006501.33373449
30Olfactory transduction_Homo sapiens_hsa047401.31722189
31Glutamatergic synapse_Homo sapiens_hsa047241.29104060
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.24461780
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.21886028
34Dopaminergic synapse_Homo sapiens_hsa047281.16055964
35Selenocompound metabolism_Homo sapiens_hsa004501.12963244
36Insulin secretion_Homo sapiens_hsa049111.11769781
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11598602
38Cocaine addiction_Homo sapiens_hsa050301.07392066
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07121397
40Amphetamine addiction_Homo sapiens_hsa050311.01625713
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01055683
42Renin secretion_Homo sapiens_hsa049241.00208793
43SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97198870
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95513489
45Proteasome_Homo sapiens_hsa030500.94492218
46Long-term depression_Homo sapiens_hsa047300.94475555
47Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92800728
48Serotonergic synapse_Homo sapiens_hsa047260.92579681
49Fatty acid elongation_Homo sapiens_hsa000620.91597830
50Salivary secretion_Homo sapiens_hsa049700.91176592
51Calcium signaling pathway_Homo sapiens_hsa040200.87760429
52Tryptophan metabolism_Homo sapiens_hsa003800.87042842
53Cholinergic synapse_Homo sapiens_hsa047250.82785587
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79405663
55Vibrio cholerae infection_Homo sapiens_hsa051100.73724242
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71632165
57Phototransduction_Homo sapiens_hsa047440.71550755
58Synaptic vesicle cycle_Homo sapiens_hsa047210.70800311
59Gastric acid secretion_Homo sapiens_hsa049710.70285036
60Caffeine metabolism_Homo sapiens_hsa002320.69502005
61Long-term potentiation_Homo sapiens_hsa047200.68730735
62Mineral absorption_Homo sapiens_hsa049780.68606626
63Linoleic acid metabolism_Homo sapiens_hsa005910.67807792
64Type I diabetes mellitus_Homo sapiens_hsa049400.61762086
65Starch and sucrose metabolism_Homo sapiens_hsa005000.59357963
66RNA polymerase_Homo sapiens_hsa030200.56567603
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56460506
68Collecting duct acid secretion_Homo sapiens_hsa049660.56404216
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55677368
70Sulfur metabolism_Homo sapiens_hsa009200.54609942
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54582358
72beta-Alanine metabolism_Homo sapiens_hsa004100.53007750
73Metabolic pathways_Homo sapiens_hsa011000.53001258
74RNA degradation_Homo sapiens_hsa030180.52317861
75Circadian rhythm_Homo sapiens_hsa047100.47861246
76Thyroid hormone synthesis_Homo sapiens_hsa049180.44361134
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43854627
78African trypanosomiasis_Homo sapiens_hsa051430.43622969
79Gap junction_Homo sapiens_hsa045400.42706790
80Pancreatic secretion_Homo sapiens_hsa049720.42352437
81Phenylalanine metabolism_Homo sapiens_hsa003600.41484545
82Ovarian steroidogenesis_Homo sapiens_hsa049130.41052897
83Dilated cardiomyopathy_Homo sapiens_hsa054140.39224731
84Oxytocin signaling pathway_Homo sapiens_hsa049210.38183350
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36308167
86Fat digestion and absorption_Homo sapiens_hsa049750.36154219
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35322039
88Propanoate metabolism_Homo sapiens_hsa006400.35237348
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34374782
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34298174
91Ether lipid metabolism_Homo sapiens_hsa005650.34089838
92Basal transcription factors_Homo sapiens_hsa030220.32605699
93Regulation of autophagy_Homo sapiens_hsa041400.31868535
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31504356
95Peroxisome_Homo sapiens_hsa041460.30362640
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29064632
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28175115
98Tight junction_Homo sapiens_hsa045300.27877006
99Asthma_Homo sapiens_hsa053100.27337463
100Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.27241046

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