CALHM3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of hippo signaling (GO:0035330)7.43277916
2paraxial mesoderm development (GO:0048339)7.33290864
3monoubiquitinated protein deubiquitination (GO:0035520)6.28930680
4regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)6.05905556
5mitotic chromosome condensation (GO:0007076)5.76595330
6establishment of integrated proviral latency (GO:0075713)5.74325272
7notochord development (GO:0030903)5.73551180
8negative regulation of DNA-templated transcription, elongation (GO:0032785)5.67092789
9negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)5.67092789
10establishment of viral latency (GO:0019043)5.64786767
11nuclear pore complex assembly (GO:0051292)5.62328085
12regulation of spindle organization (GO:0090224)5.38489725
13gonadal mesoderm development (GO:0007506)5.34801622
14proteasome assembly (GO:0043248)5.29211680
15regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)5.24116934
16nuclear pore organization (GO:0006999)4.91866852
17negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.88220873
18synapsis (GO:0007129)4.86185371
19mitotic metaphase plate congression (GO:0007080)4.84448746
20positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.72350641
21carnitine shuttle (GO:0006853)4.70701357
22regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.66751258
23inner cell mass cell proliferation (GO:0001833)4.60719064
24negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.55078757
25negative regulation of ligase activity (GO:0051352)4.55078757
26mitotic nuclear envelope reassembly (GO:0007084)4.53343837
27nuclear envelope reassembly (GO:0031468)4.53343837
28regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.50723150
29cellular response to gamma radiation (GO:0071480)4.50040934
30histone lysine demethylation (GO:0070076)4.46917966
31anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.46364740
32regulation of cellular amino acid metabolic process (GO:0006521)4.44589406
33regulation of mitotic spindle organization (GO:0060236)4.42474532
34regulation of translational termination (GO:0006449)4.41394885
35mitotic sister chromatid segregation (GO:0000070)4.35551295
36mitotic nuclear envelope disassembly (GO:0007077)4.34610176
37DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.32985349
38female gamete generation (GO:0007292)4.27918088
39signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.27218645
40intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.27218645
41signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.25527385
42signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.25527385
43signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.25527385
44sphingosine metabolic process (GO:0006670)4.22889793
45cellular protein complex localization (GO:0034629)4.22674804
46negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.21215109
47signal transduction involved in DNA damage checkpoint (GO:0072422)4.20717227
48signal transduction involved in DNA integrity checkpoint (GO:0072401)4.20717227
49histone demethylation (GO:0016577)4.20336320
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.17441601
51negative regulation of cell aging (GO:0090344)4.14364917
52pore complex assembly (GO:0046931)4.14018427
53protein maturation by protein folding (GO:0022417)4.11696590
54DNA replication checkpoint (GO:0000076)4.11365972
55membrane disassembly (GO:0030397)4.10667405
56nuclear envelope disassembly (GO:0051081)4.10667405
57positive regulation of ubiquitin-protein transferase activity (GO:0051443)4.10351810
58signal transduction involved in cell cycle checkpoint (GO:0072395)4.09808862
59corticosteroid receptor signaling pathway (GO:0031958)4.06817348
60DNA damage response, signal transduction resulting in transcription (GO:0042772)4.03778157
61microtubule depolymerization (GO:0007019)3.99541621
62DNA synthesis involved in DNA repair (GO:0000731)3.99396999
63DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.93444478
64regulation of RNA export from nucleus (GO:0046831)3.93263800
65positive regulation of ligase activity (GO:0051351)3.88497130
66antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.87862195
67vitamin transmembrane transport (GO:0035461)3.86157601
68negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.85531656
69protein demethylation (GO:0006482)3.85103237
70protein dealkylation (GO:0008214)3.85103237
71sister chromatid cohesion (GO:0007062)3.84797480
72fatty acid transmembrane transport (GO:1902001)3.81817836
73positive regulation of vesicle fusion (GO:0031340)3.80918587
74pentose-phosphate shunt (GO:0006098)3.80200509
75oogenesis (GO:0048477)3.80131337
76regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)3.78173201
77regulation of metalloenzyme activity (GO:0048552)3.77636719
78glucose catabolic process (GO:0006007)3.75631395
79negative regulation of fatty acid biosynthetic process (GO:0045717)3.75076383
80diol metabolic process (GO:0034311)3.73854717
81regulation of ubiquitin-protein transferase activity (GO:0051438)3.73146943
82sister chromatid segregation (GO:0000819)3.69600775
83mitotic sister chromatid cohesion (GO:0007064)3.69433154
84histone H3-K4 methylation (GO:0051568)3.64844330
85metaphase plate congression (GO:0051310)3.61840079
86ribosomal large subunit biogenesis (GO:0042273)3.61260753
87protein complex localization (GO:0031503)3.57263143
88meiotic chromosome segregation (GO:0045132)3.57229612
89negative regulation of peptidyl-lysine acetylation (GO:2000757)3.56634967
90regulation of ligase activity (GO:0051340)3.56298798
91regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.50510843
92positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.50052886
93protein localization to kinetochore (GO:0034501)3.49296122
94regulation of mitochondrial translation (GO:0070129)3.48123567
95Golgi transport vesicle coating (GO:0048200)3.47462205
96COPI coating of Golgi vesicle (GO:0048205)3.47462205
97telomere maintenance via semi-conservative replication (GO:0032201)3.45694628
98regulation of cellular amine metabolic process (GO:0033238)3.44487684
99G1 DNA damage checkpoint (GO:0044783)3.44335893
100protein retention in ER lumen (GO:0006621)3.42598630
101intracellular estrogen receptor signaling pathway (GO:0030520)3.42539717
102maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.42203317
103meiosis I (GO:0007127)3.41873584
104snRNA transcription (GO:0009301)3.41433838
105chromatin silencing (GO:0006342)3.40173191
106chromosome organization involved in meiosis (GO:0070192)3.39292175
107NADPH regeneration (GO:0006740)3.36970545
108regulation of chromatin silencing (GO:0031935)3.36392125
109ribosome assembly (GO:0042255)3.35304592
110histone H4-K12 acetylation (GO:0043983)3.34039387
111regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.31906938
112pyrimidine dimer repair (GO:0006290)3.30211621
113histone H3-K36 demethylation (GO:0070544)3.29184556
114antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.28977723
115histone H3-K9 methylation (GO:0051567)3.27865923
116pentose metabolic process (GO:0019321)3.27658159
117lipopolysaccharide biosynthetic process (GO:0009103)3.26642261
118protein localization to chromosome, centromeric region (GO:0071459)3.26265987
119negative regulation of protein ubiquitination (GO:0031397)3.26153128
120carnitine transmembrane transport (GO:1902603)3.21652835
121mitotic G1 DNA damage checkpoint (GO:0031571)3.21396831
122purine nucleobase biosynthetic process (GO:0009113)3.21023289
123protein K6-linked ubiquitination (GO:0085020)3.20887935
124regulation of keratinocyte proliferation (GO:0010837)3.20251589
125DNA strand elongation involved in DNA replication (GO:0006271)3.20041714
126nucleobase-containing small molecule interconversion (GO:0015949)3.18977000
127positive regulation of cell cycle arrest (GO:0071158)3.18409253
128regulation of helicase activity (GO:0051095)3.16211322
129pre-miRNA processing (GO:0031054)3.16188811
130folic acid metabolic process (GO:0046655)3.14514526
131membrane raft organization (GO:0031579)3.13655907
132nuclear envelope organization (GO:0006998)3.13003487
133DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.12762336
134male meiosis I (GO:0007141)3.11107201
135chromosome condensation (GO:0030261)3.10158542
136negative regulation of protein modification by small protein conjugation or removal (GO:1903321)3.09429924
137positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.07953900
138regulation of nucleobase-containing compound transport (GO:0032239)3.06012147
139glucocorticoid receptor signaling pathway (GO:0042921)3.05093389
140DNA strand elongation (GO:0022616)3.02842953
141regulation of establishment of cell polarity (GO:2000114)3.01849748
142positive regulation of DNA-templated transcription, initiation (GO:2000144)3.01776652
143regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.98905715
144negative regulation of protein acetylation (GO:1901984)2.98825877
145sphingoid metabolic process (GO:0046519)2.97376280
146desmosome organization (GO:0002934)2.96314792
147growth hormone receptor signaling pathway (GO:0060396)2.93957460
148morphogenesis of an epithelial fold (GO:0060571)2.93390708
149positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.92391070
150formation of translation preinitiation complex (GO:0001731)2.91796775
151amino-acid betaine transport (GO:0015838)2.91419287
152carnitine transport (GO:0015879)2.91419287
153intracellular lipid transport (GO:0032365)2.90322381
154mitotic G1/S transition checkpoint (GO:0044819)2.89780310
155regulation of double-strand break repair via homologous recombination (GO:0010569)2.89523579
156signal transduction in response to DNA damage (GO:0042770)2.89458681
157negative regulation of circadian rhythm (GO:0042754)2.89210199
158chromosome segregation (GO:0007059)2.87072205
159male meiosis (GO:0007140)2.86317236
160histone H2A monoubiquitination (GO:0035518)2.85261802
161DNA unwinding involved in DNA replication (GO:0006268)2.82898588
162negative regulation of DNA repair (GO:0045738)2.81511721
163negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.78923563
164telomere maintenance via recombination (GO:0000722)2.78443394
165pseudouridine synthesis (GO:0001522)2.75360264
166G1/S transition of mitotic cell cycle (GO:0000082)2.73655880
167cell cycle G1/S phase transition (GO:0044843)2.73655880
168regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.68251747
169negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.67592563
170negative regulation of cell cycle G1/S phase transition (GO:1902807)2.67592563
171protein targeting to mitochondrion (GO:0006626)2.66282303
172pyrimidine nucleoside salvage (GO:0043097)2.64563472
173pyrimidine-containing compound salvage (GO:0008655)2.64563472
174regulation of cell cycle arrest (GO:0071156)2.63195349
175apoptotic cell clearance (GO:0043277)2.62677115
176transcription-coupled nucleotide-excision repair (GO:0006283)2.61447758
177positive regulation of protein ubiquitination (GO:0031398)2.60999170
178cellular response to interferon-alpha (GO:0035457)2.59705332
179meiotic nuclear division (GO:0007126)2.58806500
180positive regulation of actin filament depolymerization (GO:0030836)2.58433185
181hepatocyte apoptotic process (GO:0097284)2.57863470
182ribonucleoprotein complex biogenesis (GO:0022613)2.57843176
183establishment of protein localization to mitochondrial membrane (GO:0090151)2.57344612
184negative regulation of chromosome segregation (GO:0051985)2.57201349
185negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.57033075
186negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.57033075
187negative regulation of mitotic sister chromatid segregation (GO:0033048)2.57033075
188negative regulation of mitotic sister chromatid separation (GO:2000816)2.57033075
189negative regulation of sister chromatid segregation (GO:0033046)2.57033075
190piRNA metabolic process (GO:0034587)2.54734409
191spliceosomal snRNP assembly (GO:0000387)2.54044205
192protein localization to mitochondrion (GO:0070585)2.52162700

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.92442671
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.82181853
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.93222783
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.52719394
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.42071203
6AR_21909140_ChIP-Seq_LNCAP_Human3.40304925
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.17069526
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.14834048
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.09543304
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.94741253
11KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.79031243
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.76420454
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.74081133
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.72649988
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.67342911
16KAP1_22055183_ChIP-Seq_ESCs_Mouse2.58699492
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.51188817
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.46421134
19POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.40752769
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.40176787
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.34165825
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.34162389
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.33829843
24DCP1A_22483619_ChIP-Seq_HELA_Human2.31185685
25SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.23156846
26SALL1_21062744_ChIP-ChIP_HESCs_Human2.22991160
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.21105057
28MYC_19079543_ChIP-ChIP_MESCs_Mouse2.18245993
29E2F1_21310950_ChIP-Seq_MCF-7_Human2.16672904
30GATA1_26923725_Chip-Seq_HPCs_Mouse2.14278170
31E2F1_18555785_ChIP-Seq_MESCs_Mouse2.12978517
32ETS1_20019798_ChIP-Seq_JURKAT_Human2.06240479
33MYC_18555785_ChIP-Seq_MESCs_Mouse2.05075601
34HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse2.05023996
35EST1_17652178_ChIP-ChIP_JURKAT_Human2.00822549
36NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.98158356
37KDM5A_27292631_Chip-Seq_BREAST_Human1.92361830
38NANOG_21062744_ChIP-ChIP_HESCs_Human1.88817178
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.88733337
40ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.81222107
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.77494396
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.76475915
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.76020638
44TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.72823548
45* ATF3_27146783_Chip-Seq_COLON_Human1.67635139
46CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.65955164
47KLF4_18555785_ChIP-Seq_MESCs_Mouse1.63887286
48XRN2_22483619_ChIP-Seq_HELA_Human1.60219687
49TCF3_18692474_ChIP-Seq_MESCs_Mouse1.60172863
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.56000819
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.55884421
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53472928
53CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.52737402
54ZNF263_19887448_ChIP-Seq_K562_Human1.51691846
55SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.48925322
56SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.48925322
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48866776
58NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.48439821
59PKCTHETA_26484144_Chip-Seq_BREAST_Human1.47788591
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.46125909
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45990665
62ELK1_19687146_ChIP-ChIP_HELA_Human1.45454922
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.42777857
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.42074995
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40720836
66FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.39252527
67MYC_19030024_ChIP-ChIP_MESCs_Mouse1.37510874
68NELFA_20434984_ChIP-Seq_ESCs_Mouse1.35975862
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35958034
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.34715745
71KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34104527
72TCF3_18692474_ChIP-Seq_MEFs_Mouse1.34023789
73KAP1_27257070_Chip-Seq_ESCs_Mouse1.32573862
74TTF2_22483619_ChIP-Seq_HELA_Human1.31727974
75PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.30934446
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30788890
77CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.29141239
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28582024
79VDR_23849224_ChIP-Seq_CD4+_Human1.27519207
80TFEB_21752829_ChIP-Seq_HELA_Human1.26192606
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26141187
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25958887
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24074822
84YY1_21170310_ChIP-Seq_MESCs_Mouse1.23464271
85ELK3_25401928_ChIP-Seq_HUVEC_Human1.22797219
86SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20712490
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20600201
88KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.19674961
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18004513
90TP53_16413492_ChIP-PET_HCT116_Human1.16764461
91FOXP3_21729870_ChIP-Seq_TREG_Human1.16435647
92POU5F1_16518401_ChIP-PET_MESCs_Mouse1.15405995
93ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15208916
94PPAR_26484153_Chip-Seq_NCI-H1993_Human1.14827498
95CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14826424
96RUNX1_26923725_Chip-Seq_HPCs_Mouse1.14405797
97HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13559461
98CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13466072
99HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12910170
100PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11954145
101RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11938850
102RACK7_27058665_Chip-Seq_MCF-7_Human1.11280921
103ELF1_17652178_ChIP-ChIP_JURKAT_Human1.11074869
104PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.10948035
105NANOG_18692474_ChIP-Seq_MESCs_Mouse1.10275460
106SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10064725
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09984867
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09984867
109TBX5_21415370_ChIP-Seq_HL-1_Mouse1.08524469
110DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06503036
111TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.06144290
112ELK1_22589737_ChIP-Seq_MCF10A_Human1.04063679
113MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.02959839
114HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02683208
115ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02144173
116KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.01354950
117ELF5_23300383_ChIP-Seq_T47D_Human1.01163694
118SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97328700
119CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97058345
120DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96519663
121SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96503128
122SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95876699
123NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95803176
124PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95764643
125CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.95691971
126CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94869594
127YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94524418
128TET1_21451524_ChIP-Seq_MESCs_Mouse0.94375836
129SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94154132
130MYC_22102868_ChIP-Seq_BL_Human0.94059098
131NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.93005216
132POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92841650
133PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92570307
134SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91654672
135SOX17_20123909_ChIP-Seq_XEN_Mouse0.91501893
136SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91307441
137PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90980905
138STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90354400
139SOX2_18692474_ChIP-Seq_MESCs_Mouse0.90255498
140ESR1_20079471_ChIP-ChIP_T-47D_Human0.89591384
141TBL1_22424771_ChIP-Seq_293T_Human0.87572901
142SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.86834259
143CREB1_26743006_Chip-Seq_LNCaP_Human0.85006918
144POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.83106726
145STAT6_21828071_ChIP-Seq_BEAS2B_Human0.82846959
146KDM2B_26808549_Chip-Seq_DND41_Human0.82273003
147P300_27058665_Chip-Seq_ZR-75-30cells_Human0.81738989
148STAT3_18555785_ChIP-Seq_MESCs_Mouse0.81561797
149FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81285397
150NOTCH1_21737748_ChIP-Seq_TLL_Human0.81095752
151SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.80800884
152E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.79225118
153MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.79048626
154GABP_19822575_ChIP-Seq_HepG2_Human0.78812302
155POU5F1_16153702_ChIP-ChIP_HESCs_Human0.76438991
156ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.73929420
157ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.73614834
158POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.73423258
159KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.72795703
160KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.72127601
161ELK4_26923725_Chip-Seq_MESODERM_Mouse0.71963543
162TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.69632332
163GF1_26923725_Chip-Seq_HPCs_Mouse0.69599810
164NFYA_21822215_ChIP-Seq_K562_Human0.69599693
165KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.68951724
166CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.67506107
167SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.67236725
168MYC_18358816_ChIP-ChIP_MESCs_Mouse0.66503916
169KDM2B_26808549_Chip-Seq_JURKAT_Human0.66221466
170NANOG_18692474_ChIP-Seq_MEFs_Mouse0.65539907

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.84289753
2MP0005451_abnormal_body_composition4.79059167
3MP0003693_abnormal_embryo_hatching4.23363748
4MP0003077_abnormal_cell_cycle3.65674664
5MP0004185_abnormal_adipocyte_glucose3.57749132
6MP0003111_abnormal_nucleus_morphology3.42414058
7MP0003806_abnormal_nucleotide_metabolis3.30692761
8MP0003890_abnormal_embryonic-extraembry3.28305657
9MP0009697_abnormal_copulation3.06259993
10MP0002653_abnormal_ependyma_morphology2.87127171
11MP0010030_abnormal_orbit_morphology2.66636740
12MP0001346_abnormal_lacrimal_gland2.62678125
13MP0003191_abnormal_cellular_cholesterol2.56346540
14MP0008007_abnormal_cellular_replicative2.54540596
15MP0005083_abnormal_biliary_tract2.53612634
16MP0002163_abnormal_gland_morphology2.45467855
17MP0005310_abnormal_salivary_gland2.44336443
18MP0000350_abnormal_cell_proliferation2.37638886
19MP0004957_abnormal_blastocyst_morpholog2.33317283
20MP0001849_ear_inflammation2.24542130
21MP0001730_embryonic_growth_arrest2.23093958
22MP0003950_abnormal_plasma_membrane2.21734697
23MP0003937_abnormal_limbs/digits/tail_de2.11079996
24MP0002877_abnormal_melanocyte_morpholog2.00201662
25MP0002160_abnormal_reproductive_system1.99899814
26MP0000566_synostosis1.97964092
27MP0005423_abnormal_somatic_nervous1.86322574
28MP0010094_abnormal_chromosome_stability1.84399968
29MP0003718_maternal_effect1.79225727
30MP0003186_abnormal_redox_activity1.76720795
31MP0001986_abnormal_taste_sensitivity1.75780658
32MP0009780_abnormal_chondrocyte_physiolo1.74759427
33MP0001661_extended_life_span1.73466225
34MP0003705_abnormal_hypodermis_morpholog1.68815428
35MP0005380_embryogenesis_phenotype1.68405568
36MP0001672_abnormal_embryogenesis/_devel1.68405568
37MP0003566_abnormal_cell_adhesion1.66997928
38MP0009333_abnormal_splenocyte_physiolog1.61773149
39MP0005187_abnormal_penis_morphology1.60981440
40MP0010234_abnormal_vibrissa_follicle1.59279069
41MP0000343_altered_response_to1.58359262
42MP0001697_abnormal_embryo_size1.57133364
43MP0002085_abnormal_embryonic_tissue1.56810165
44MP0005501_abnormal_skin_physiology1.56111542
45MP0010307_abnormal_tumor_latency1.54196924
46MP0000358_abnormal_cell_content/1.52802886
47MP0003221_abnormal_cardiomyocyte_apopto1.52086098
48MP0003941_abnormal_skin_development1.51775804
49MP0005076_abnormal_cell_differentiation1.50537140
50MP0000858_altered_metastatic_potential1.50203711
51MP0005408_hypopigmentation1.47911162
52MP0002084_abnormal_developmental_patter1.46579516
53MP0000383_abnormal_hair_follicle1.45613625
54MP0005165_increased_susceptibility_to1.43545877
55MP0008058_abnormal_DNA_repair1.42612817
56MP0005647_abnormal_sex_gland1.42004170
57MP0005666_abnormal_adipose_tissue1.41519621
58MP0009053_abnormal_anal_canal1.41506857
59MP0003453_abnormal_keratinocyte_physiol1.39155828
60MP0005023_abnormal_wound_healing1.38299509
61MP0003786_premature_aging1.38078129
62MP0000762_abnormal_tongue_morphology1.34935813
63MP0002796_impaired_skin_barrier1.34850410
64MP0003984_embryonic_growth_retardation1.34837303
65MP0001853_heart_inflammation1.33967074
66MP0003938_abnormal_ear_development1.33552294
67MP0002060_abnormal_skin_morphology1.32987634
68MP0010678_abnormal_skin_adnexa1.31972502
69MP0001545_abnormal_hematopoietic_system1.31726434
70MP0005397_hematopoietic_system_phenotyp1.31726434
71MP0005379_endocrine/exocrine_gland_phen1.31059135
72MP0001929_abnormal_gametogenesis1.30270877
73MP0002088_abnormal_embryonic_growth/wei1.28814779
74MP0002210_abnormal_sex_determination1.26864997
75MP0005257_abnormal_intraocular_pressure1.26370473
76MP0000537_abnormal_urethra_morphology1.25134319
77MP0003315_abnormal_perineum_morphology1.24993147
78MP0002148_abnormal_hypersensitivity_rea1.24567914
79MP0001216_abnormal_epidermal_layer1.22390212
80MP0001881_abnormal_mammary_gland1.21695489
81MP0010352_gastrointestinal_tract_polyps1.21041594
82MP0002086_abnormal_extraembryonic_tissu1.17960888
83MP0002006_tumorigenesis1.17723341
84MP0009278_abnormal_bone_marrow1.15105868
85MP0004264_abnormal_extraembryonic_tissu1.13946460
86MP0001119_abnormal_female_reproductive1.11985503
87MP0005330_cardiomyopathy1.11265185
88MP0005058_abnormal_lysosome_morphology1.10925477
89MP0002080_prenatal_lethality1.08724945
90MP0005623_abnormal_meninges_morphology1.08577712
91MP0000313_abnormal_cell_death1.06650746
92MP0005384_cellular_phenotype1.06363271
93MP0008260_abnormal_autophagy1.05327738
94MP0000750_abnormal_muscle_regeneration1.05266753
95MP0000427_abnormal_hair_cycle1.05058346
96MP0010771_integument_phenotype1.04133462
97MP0003868_abnormal_feces_composition1.03087235
98MP0008961_abnormal_basal_metabolism1.03003225
99MP0003119_abnormal_digestive_system1.01747617
100MP0003699_abnormal_female_reproductive1.01537596
101MP0002019_abnormal_tumor_incidence1.01416979
102MP0001915_intracranial_hemorrhage0.99552840
103MP0000003_abnormal_adipose_tissue0.99320949
104MP0009840_abnormal_foam_cell0.99162542
105MP0002233_abnormal_nose_morphology0.98558753
106MP0004885_abnormal_endolymph0.97824391
107MP0009672_abnormal_birth_weight0.97365480
108MP0000627_abnormal_mammary_gland0.97305093
109MP0001145_abnormal_male_reproductive0.96270840
110MP0004272_abnormal_basement_membrane0.95915490
111MP0004233_abnormal_muscle_weight0.95647719
112MP0005197_abnormal_uvea_morphology0.95389057
113MP0000653_abnormal_sex_gland0.94936771
114MP0006036_abnormal_mitochondrial_physio0.94071455
115MP0008877_abnormal_DNA_methylation0.93349611
116MP0003632_abnormal_nervous_system0.92094889
117MP0001299_abnormal_eye_distance/0.91226933
118MP0005395_other_phenotype0.89715018
119MP0000647_abnormal_sebaceous_gland0.89640081
120MP0000428_abnormal_craniofacial_morphol0.88888392
121MP0003755_abnormal_palate_morphology0.87784848
122MP0005164_abnormal_response_to0.87488732
123MP0000579_abnormal_nail_morphology0.86885954
124MP0000372_irregular_coat_pigmentation0.86635807
125MP0005621_abnormal_cell_physiology0.86325913
126MP0001486_abnormal_startle_reflex0.85508891
127MP0002249_abnormal_larynx_morphology0.85401396
128MP0005375_adipose_tissue_phenotype0.85176904
129MP0003385_abnormal_body_wall0.84843159
130MP0005389_reproductive_system_phenotype0.83727054
131MP0000613_abnormal_salivary_gland0.80052317
132MP0003935_abnormal_craniofacial_develop0.78385835
133MP0005166_decreased_susceptibility_to0.77084069
134MP0006292_abnormal_olfactory_placode0.76922278
135MP0001243_abnormal_dermal_layer0.75992562
136MP0002098_abnormal_vibrissa_morphology0.75590476
137MP0003943_abnormal_hepatobiliary_system0.75517880
138MP0004197_abnormal_fetal_growth/weight/0.73730193
139MP0002396_abnormal_hematopoietic_system0.73569707
140MP0003861_abnormal_nervous_system0.73433180
141MP0008932_abnormal_embryonic_tissue0.72842601
142MP0003828_pulmonary_edema0.72185762
143MP0000490_abnormal_crypts_of0.71001550
144MP0006035_abnormal_mitochondrial_morpho0.70469533
145MP0000432_abnormal_head_morphology0.69718276
146MP0003936_abnormal_reproductive_system0.69712668
147MP0003115_abnormal_respiratory_system0.67802933
148MP0006138_congestive_heart_failure0.67776332
149MP0003123_paternal_imprinting0.67358688
150MP0003075_altered_response_to0.67247414
151MP0002161_abnormal_fertility/fecundity0.67088093
152MP0005275_abnormal_skin_tensile0.66227870
153MP0009250_abnormal_appendicular_skeleto0.66183460
154MP0000639_abnormal_adrenal_gland0.66081163
155MP0000462_abnormal_digestive_system0.63421467
156MP0000733_abnormal_muscle_development0.63405345
157MP0003567_abnormal_fetal_cardiomyocyte0.63207492
158MP0001851_eye_inflammation0.62797897

Predicted human phenotypes

RankGene SetZ-score
1Atrioventricular block (HP:0001678)6.15442771
2Birth length less than 3rd percentile (HP:0003561)5.68022518
3Papillary thyroid carcinoma (HP:0002895)5.39633393
4Sparse lateral eyebrow (HP:0005338)5.07754118
5Lip pit (HP:0100267)4.70772830
6Shawl scrotum (HP:0000049)4.37721949
7Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.18946387
8Abnormality of alanine metabolism (HP:0010916)4.18946387
9Hyperalaninemia (HP:0003348)4.18946387
10Heart block (HP:0012722)4.07770591
11Breast hypoplasia (HP:0003187)4.06233712
12Abnormality of the labia minora (HP:0012880)3.96293389
13Shoulder girdle muscle weakness (HP:0003547)3.86625333
14Abnormal atrioventricular conduction (HP:0005150)3.80540720
15Urethral obstruction (HP:0000796)3.78841253
16Abnormality of the fingertips (HP:0001211)3.69418846
17Breast aplasia (HP:0100783)3.69064772
18Autoimmune thrombocytopenia (HP:0001973)3.59418288
19Reduced subcutaneous adipose tissue (HP:0003758)3.58800758
20Focal motor seizures (HP:0011153)3.57993422
21Ectopic kidney (HP:0000086)3.55403147
22Patellar aplasia (HP:0006443)3.52246316
23Upper limb muscle weakness (HP:0003484)3.45683200
24Anal stenosis (HP:0002025)3.35340839
25Depressed nasal tip (HP:0000437)3.34445100
26Aplasia/Hypoplasia of the breasts (HP:0010311)3.30216533
27Sensorimotor neuropathy (HP:0007141)3.28099770
28Aplasia/Hypoplasia of the patella (HP:0006498)3.24913669
29Coarctation of aorta (HP:0001680)3.22267256
30Abnormality of glycolysis (HP:0004366)3.20134493
31Rough bone trabeculation (HP:0100670)3.19979031
32Sparse eyelashes (HP:0000653)3.18890655
33Posterior embryotoxon (HP:0000627)3.15699959
34Glucose intolerance (HP:0000833)3.12464814
35Facial hemangioma (HP:0000329)3.10712430
36Pili torti (HP:0003777)3.09271555
37Abnormal hair laboratory examination (HP:0003328)3.08401293
38Abnormality of the line of Schwalbe (HP:0008048)3.06233517
39Osteolytic defects of the phalanges of the hand (HP:0009771)3.05801802
40Osteolytic defects of the hand bones (HP:0009699)3.05801802
41Long eyelashes (HP:0000527)3.03722000
42Onycholysis (HP:0001806)3.00549709
43Abdominal situs inversus (HP:0003363)2.99085721
44Abnormality of abdominal situs (HP:0011620)2.99085721
45Abnormality of the preputium (HP:0100587)2.98390167
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.95787673
47Increased serum pyruvate (HP:0003542)2.89269281
48Nuclear cataract (HP:0100018)2.89146132
49High anterior hairline (HP:0009890)2.88761860
50Prominent nose (HP:0000448)2.86446142
51Adrenal hypoplasia (HP:0000835)2.85723771
52Intestinal fistula (HP:0100819)2.84624366
53Thyroid carcinoma (HP:0002890)2.82192296
54Entropion (HP:0000621)2.79241831
55Hyperacusis (HP:0010780)2.75945831
56Meckel diverticulum (HP:0002245)2.71749273
57Micronodular cirrhosis (HP:0001413)2.58635437
58Short 5th finger (HP:0009237)2.56822570
59Congenital, generalized hypertrichosis (HP:0004540)2.56676277
60Microretrognathia (HP:0000308)2.47147165
61Abnormal mitochondria in muscle tissue (HP:0008316)2.46270823
62Hepatocellular necrosis (HP:0001404)2.45869731
63Ventricular tachycardia (HP:0004756)2.44525546
64Abnormality of the ileum (HP:0001549)2.44348591
65Short nail (HP:0001799)2.43009087
66Abnormal trabecular bone morphology (HP:0100671)2.37370317
67Trismus (HP:0000211)2.35548285
68Flat capital femoral epiphysis (HP:0003370)2.35072086
69Broad face (HP:0000283)2.34182392
70Increased intramyocellular lipid droplets (HP:0012240)2.33642226
71Pelvic girdle muscle weakness (HP:0003749)2.33516240
72Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.33084459
73Abnormal protein N-linked glycosylation (HP:0012347)2.33084459
74Abnormal protein glycosylation (HP:0012346)2.33084459
75Abnormal glycosylation (HP:0012345)2.33084459
76Selective tooth agenesis (HP:0001592)2.32509266
77Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.32421982
78Abnormality of the distal phalanges of the toes (HP:0010182)2.30090894
79Hepatic necrosis (HP:0002605)2.29749173
80Abnormal pupillary function (HP:0007686)2.27255811
81Type I transferrin isoform profile (HP:0003642)2.26674176
82Aplasia/Hypoplasia of the sacrum (HP:0008517)2.26642913
83Cholecystitis (HP:0001082)2.26463084
84Abnormal gallbladder physiology (HP:0012438)2.26463084
85Abnormality of the vocal cords (HP:0008777)2.26167709
86Anterior segment dysgenesis (HP:0007700)2.25751079
87Capillary hemangiomas (HP:0005306)2.25495532
88Ureteral stenosis (HP:0000071)2.25444054
89Hypoplastic labia majora (HP:0000059)2.24488260
90Vacuolated lymphocytes (HP:0001922)2.24081683
91Esophageal atresia (HP:0002032)2.23769959
92Prostate neoplasm (HP:0100787)2.21085741
93Aplasia/Hypoplasia of the sternum (HP:0006714)2.20779137
94Dry hair (HP:0011359)2.20194864
95Microglossia (HP:0000171)2.19986210
96Abnormality of chromosome stability (HP:0003220)2.18831689
97Ureteral obstruction (HP:0006000)2.18830713
98Mitochondrial inheritance (HP:0001427)2.18708036
99Squamous cell carcinoma (HP:0002860)2.18597470
100Rhabdomyolysis (HP:0003201)2.17805243
101Increased serum lactate (HP:0002151)2.17592057
102Visual hallucinations (HP:0002367)2.16976518
103Erythema (HP:0010783)2.16357819
104Deviation of the thumb (HP:0009603)2.16177355
105Acute necrotizing encephalopathy (HP:0006965)2.15949098
106Insomnia (HP:0100785)2.14718890
107Gout (HP:0001997)2.13782613
108Acute myeloid leukemia (HP:0004808)2.13569290
109Brittle hair (HP:0002299)2.11669846
110Limb-girdle muscle atrophy (HP:0003797)2.11053468
111Woolly hair (HP:0002224)2.10640633
112Increased CSF lactate (HP:0002490)2.10328765
113Myelodysplasia (HP:0002863)2.10232855
114Aplasia/Hypoplasia of the fovea (HP:0008060)2.09789862
115Hypoplasia of the fovea (HP:0007750)2.09789862
116Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.08793918
117Decreased activity of mitochondrial respiratory chain (HP:0008972)2.08793918
118Progressive sensorineural hearing impairment (HP:0000408)2.08690096
119Impulsivity (HP:0100710)2.07111931
120Abnormality of the musculature of the pelvis (HP:0001469)2.06808268
121Abnormality of the hip-girdle musculature (HP:0001445)2.06808268
122Orthostatic hypotension (HP:0001278)2.05238371
123Proximal placement of thumb (HP:0009623)2.05222962
124Cafe-au-lait spot (HP:0000957)2.04472776
125Increased hepatocellular lipid droplets (HP:0006565)2.03896096
126Overlapping toe (HP:0001845)2.03373026
127Absent thumb (HP:0009777)2.02252180
128Acanthosis nigricans (HP:0000956)2.01682933
129Stenosis of the external auditory canal (HP:0000402)2.01411494
130Testicular atrophy (HP:0000029)2.01310280
131Polycythemia (HP:0001901)2.00999591
132Esophageal neoplasm (HP:0100751)2.00669545
133Neoplasm of head and neck (HP:0012288)2.00669545
134Tongue fasciculations (HP:0001308)1.99768537
135Ectropion (HP:0000656)1.99631755
136Abnormality of the labia majora (HP:0012881)1.99355315
137Hypokinesia (HP:0002375)1.98162252
138Male infertility (HP:0003251)1.96482715
139Distal lower limb amyotrophy (HP:0008944)1.95800829
140Abnormality of the carotid arteries (HP:0005344)1.94988758
141Overriding aorta (HP:0002623)1.94535313
142Progressive hearing impairment (HP:0001730)1.93563118
143Oligodactyly (HP:0012165)1.93187174
144Focal segmental glomerulosclerosis (HP:0000097)1.93161728
145Ridged nail (HP:0001807)1.92636727
146Difficulty climbing stairs (HP:0003551)1.92535241
147Renal Fanconi syndrome (HP:0001994)1.92157742
148Heterotopia (HP:0002282)1.91029829
149Erectile abnormalities (HP:0100639)1.89861660
150Deep palmar crease (HP:0006191)1.89693372
151Chromosomal breakage induced by crosslinking agents (HP:0003221)1.88746539
152Hemivertebrae (HP:0002937)1.88309175
153Distal lower limb muscle weakness (HP:0009053)1.87995102
154Flat cornea (HP:0007720)1.87824597
155Long palpebral fissure (HP:0000637)1.86520728
156Acute encephalopathy (HP:0006846)1.86392692
157Vertebral compression fractures (HP:0002953)1.86389612
158Renal cell carcinoma (HP:0005584)1.86383780
159Abnormality of the lower motor neuron (HP:0002366)1.85863093
160Spontaneous abortion (HP:0005268)1.85084229
161Nail dystrophy (HP:0008404)1.84506701
162Death in infancy (HP:0001522)1.84179737
163Progressive muscle weakness (HP:0003323)1.83902777
164Preauricular pit (HP:0004467)1.83237774
165Periauricular skin pits (HP:0100277)1.83237774
166Small intestinal stenosis (HP:0012848)1.83131891
167Duodenal stenosis (HP:0100867)1.83131891
168Decreased subcutaneous fat (HP:0001002)1.83128469
169Zonular cataract (HP:0010920)1.82730789
170Abnormality of cochlea (HP:0000375)1.82706868
171Short clavicles (HP:0000894)1.82401605
172Cerebral edema (HP:0002181)1.81084941
173Megalocornea (HP:0000485)1.81041015
174Tetraplegia (HP:0002445)1.80934767
175Abnormal number of erythroid precursors (HP:0012131)1.80683619
176Increased nuchal translucency (HP:0010880)1.80333664
177Abnormal glucose tolerance (HP:0001952)1.80198151
178Mask-like facies (HP:0000298)1.79784763
179Abnormality of the umbilical cord (HP:0010881)1.79780864
180Glossoptosis (HP:0000162)1.79606680
181Increased muscle lipid content (HP:0009058)1.78825353
182Achilles tendon contracture (HP:0001771)1.78754068
183Chorioretinal coloboma (HP:0000567)1.78725628
184Labial hypoplasia (HP:0000066)1.78711035
185Skin pits (HP:0100276)1.78647197
186Hypogonadotrophic hypogonadism (HP:0000044)1.74854193
187Bradycardia (HP:0001662)1.72756022
188Ependymoma (HP:0002888)1.70523448
189Clubbing of toes (HP:0100760)1.70237508
190Hypoplastic female external genitalia (HP:0012815)1.69885102
191Peritonitis (HP:0002586)1.67709553
192Oligodactyly (hands) (HP:0001180)1.67703475
193Chromsome breakage (HP:0040012)1.67306014
194Genu recurvatum (HP:0002816)1.67125427
195Bundle branch block (HP:0011710)1.66141026
196Trigonocephaly (HP:0000243)1.65886489
197Upper motor neuron abnormality (HP:0002127)1.64733664

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS27.32842137
2STK38L6.85059290
3NME25.07104326
4MST1R4.94045884
5VRK23.16657803
6STK383.06756606
7STK32.74022367
8TESK12.55780418
9PBK2.52008058
10MET2.51331847
11LIMK12.43649914
12IRAK32.43551608
13CDK122.24584472
14TESK22.19697550
15TAOK12.11286613
16TRIM282.04432616
17LATS110.1510833
18SCYL21.99953110
19ABL21.90192311
20MST41.87129581
21MAP3K121.85075732
22PAK41.81527540
23CDC71.80898504
24EIF2AK11.80461258
25ARAF1.79827521
26ERBB41.70931230
27CDK81.69770349
28SIK31.68278421
29EPHB21.61902844
30NEK21.59176771
31ZAK1.48929115
32CHEK21.45553427
33DYRK31.43640255
34PAK61.38659306
35ERN11.36988621
36BUB11.31670694
37CAMK1D1.29966838
38STK161.28152864
39BCKDK1.23772818
40EIF2AK31.21932607
41KSR21.21510726
42MAP4K21.17722705
43PDGFRB1.17341716
44SMG11.11135506
45PDK21.09750202
46MAP3K91.08932400
47RAF11.03596314
48BMX0.98666796
49TTK0.94950502
50NEK90.94077813
51PIM20.92063769
52TSSK60.91078563
53DAPK10.88843815
54SIK10.81906481
55PNCK0.80873807
56PTK20.80692469
57RPS6KA50.80439498
58KSR10.78953831
59SRPK10.78137003
60MAP3K60.76427027
61CDK70.76130644
62DAPK30.75335609
63LMTK20.74982177
64CHEK10.74569135
65LRRK20.72791282
66TLK10.64171751
67NEK10.63951109
68DDR20.63205998
69MAP3K30.62913601
70ABL10.59934460
71CAMK1G0.59522802
72MAP3K20.58883753
73ATM0.57639163
74MOS0.56795186
75PLK40.56336397
76ICK0.53492244
77PLK10.51806140
78AURKB0.48247524
79CSNK1D0.48124510
80TRIB30.47151702
81MAPK100.46827323
82MARK20.46422250
83MAP3K40.45989799
84CDK20.45573907
85BRSK10.44287623
86INSRR0.43033972
87PTK60.41987607
88ILK0.41827135
89CDK190.41761975
90MAPKAPK50.40943692
91WEE10.40667939
92CSF1R0.40500738
93CDK40.40233913
94TAOK20.39716122
95ALK0.39640675
96EIF2AK20.39287945
97PLK30.38068236
98MTOR0.37566268
99MAP3K80.36486416
100MAP2K10.36474680
101NUAK10.36471221
102MAPK110.35440308
103PRKG20.33586972
104STK100.33525019
105CSNK1G10.33001773
106PRKAA10.32857412
107MAP2K40.31935872
108BRSK20.31596052
109BCR0.30904182
110CDK10.30898927
111MELK0.30767330
112MARK30.30158613
113PRKCI0.29865769
114BRAF0.29447026
115EPHB10.28622977
116PRKCH0.28599618
117TAF10.28529738
118PTK2B0.28374741
119DMPK0.27912619
120CAMK2G0.27726333
121TBK10.27353450
122PRKD20.26498354
123STK240.26124911
124NME10.25711972
125KDR0.24778832
126VRK10.24636402
127DYRK1A0.23965064
128MAPKAPK20.23220963
129PDGFRA0.22939593
130GSK3B0.22298182
131CDK90.22167622
132PAK10.21363092
133AURKA0.21350997
134CSNK1E0.21296027
135RPS6KA40.20575980
136STK110.19715865
137EPHA20.18929358
138AKT20.18337175
139TYRO30.18177081
140MKNK20.17445163
141PAK30.17093789
142MAPK140.16991967
143MAP3K50.16182617
144RPS6KB20.14459429
145DYRK20.13473788
146PAK20.13204403
147RET0.12786102
148HCK0.11532236
149PRKAA20.11253236
150PIM10.10910003
151CSNK1G20.10435588
152CSNK1A10.09810132
153AKT10.09014787
154TAOK30.08042584
155PRKDC0.07580049
156STK40.06895130
157BRD40.06250229
158ATR0.06221896
159AKT30.05684667

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030506.42769297
2Vitamin B6 metabolism_Homo sapiens_hsa007504.48633976
3Pentose phosphate pathway_Homo sapiens_hsa000303.24243410
4RNA polymerase_Homo sapiens_hsa030203.17423219
5RNA transport_Homo sapiens_hsa030133.15023402
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.08242079
7Thyroid cancer_Homo sapiens_hsa052163.03625438
8Cell cycle_Homo sapiens_hsa041102.99981143
9p53 signaling pathway_Homo sapiens_hsa041152.86276745
10Ribosome_Homo sapiens_hsa030102.52652534
11Lysine degradation_Homo sapiens_hsa003102.46442050
12Basal transcription factors_Homo sapiens_hsa030222.32431961
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.20085913
14Fanconi anemia pathway_Homo sapiens_hsa034602.11057360
15Cyanoamino acid metabolism_Homo sapiens_hsa004601.98262012
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88157521
17Systemic lupus erythematosus_Homo sapiens_hsa053221.84502355
18Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.81826618
19Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75871901
20N-Glycan biosynthesis_Homo sapiens_hsa005101.75743322
21MicroRNAs in cancer_Homo sapiens_hsa052061.75704675
22Fructose and mannose metabolism_Homo sapiens_hsa000511.74738479
23Galactose metabolism_Homo sapiens_hsa000521.74090918
24Fatty acid elongation_Homo sapiens_hsa000621.73410487
25RNA degradation_Homo sapiens_hsa030181.73002026
26Oxidative phosphorylation_Homo sapiens_hsa001901.71948969
27Base excision repair_Homo sapiens_hsa034101.70570680
28Renal cell carcinoma_Homo sapiens_hsa052111.63185508
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.59702609
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.54038749
31Carbon metabolism_Homo sapiens_hsa012001.48185521
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.47342492
33Oocyte meiosis_Homo sapiens_hsa041141.43473860
34Biosynthesis of amino acids_Homo sapiens_hsa012301.43269408
35Parkinsons disease_Homo sapiens_hsa050121.41331077
36Non-small cell lung cancer_Homo sapiens_hsa052231.40379747
37Thyroid hormone signaling pathway_Homo sapiens_hsa049191.40271566
38Huntingtons disease_Homo sapiens_hsa050161.39521627
39Spliceosome_Homo sapiens_hsa030401.36477347
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36381227
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.34564012
42mRNA surveillance pathway_Homo sapiens_hsa030151.32343085
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.31846245
44Small cell lung cancer_Homo sapiens_hsa052221.31024153
45Homologous recombination_Homo sapiens_hsa034401.27803349
46Arginine biosynthesis_Homo sapiens_hsa002201.27215357
47ErbB signaling pathway_Homo sapiens_hsa040121.25688897
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22024130
49Nitrogen metabolism_Homo sapiens_hsa009101.20877437
50mTOR signaling pathway_Homo sapiens_hsa041501.16501816
51Hippo signaling pathway_Homo sapiens_hsa043901.15466558
52Alzheimers disease_Homo sapiens_hsa050101.14271667
53Alcoholism_Homo sapiens_hsa050341.12764692
54Bladder cancer_Homo sapiens_hsa052191.12282910
55Melanoma_Homo sapiens_hsa052181.09094543
56Endometrial cancer_Homo sapiens_hsa052131.08548408
57Glutathione metabolism_Homo sapiens_hsa004801.07132145
58Pyruvate metabolism_Homo sapiens_hsa006201.05593775
59Prolactin signaling pathway_Homo sapiens_hsa049171.05569322
60Glioma_Homo sapiens_hsa052141.04712755
61Pancreatic cancer_Homo sapiens_hsa052121.02385193
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.99502159
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97536527
64Nucleotide excision repair_Homo sapiens_hsa034200.97483578
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.96914161
66Prostate cancer_Homo sapiens_hsa052150.95952391
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95466302
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95429077
69Vibrio cholerae infection_Homo sapiens_hsa051100.94394178
70Viral myocarditis_Homo sapiens_hsa054160.94073080
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91579085
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.88490017
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88115098
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.84033700
75TGF-beta signaling pathway_Homo sapiens_hsa043500.83030752
76Purine metabolism_Homo sapiens_hsa002300.82048301
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81550711
78Chronic myeloid leukemia_Homo sapiens_hsa052200.81055085
79VEGF signaling pathway_Homo sapiens_hsa043700.79930746
80Colorectal cancer_Homo sapiens_hsa052100.78130710
81FoxO signaling pathway_Homo sapiens_hsa040680.77471255
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77426483
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76032603
84Pyrimidine metabolism_Homo sapiens_hsa002400.75058414
85Choline metabolism in cancer_Homo sapiens_hsa052310.73387938
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.72925115
87Long-term potentiation_Homo sapiens_hsa047200.71218925
88Shigellosis_Homo sapiens_hsa051310.70739666
89Sulfur metabolism_Homo sapiens_hsa009200.65383528
90Adherens junction_Homo sapiens_hsa045200.65295086
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64414482
92Sphingolipid metabolism_Homo sapiens_hsa006000.63424270
93Folate biosynthesis_Homo sapiens_hsa007900.63195915
94Non-homologous end-joining_Homo sapiens_hsa034500.62855794
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60471210
96DNA replication_Homo sapiens_hsa030300.59073961
97Linoleic acid metabolism_Homo sapiens_hsa005910.58805140
98Arginine and proline metabolism_Homo sapiens_hsa003300.58115877
99Tight junction_Homo sapiens_hsa045300.57841764
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56328268
101Metabolic pathways_Homo sapiens_hsa011000.55887899
102Ras signaling pathway_Homo sapiens_hsa040140.55644637
103Apoptosis_Homo sapiens_hsa042100.54594326
104Herpes simplex infection_Homo sapiens_hsa051680.52998215
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52685679
106Ether lipid metabolism_Homo sapiens_hsa005650.52168411
107Estrogen signaling pathway_Homo sapiens_hsa049150.49900413
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49209876
109Amphetamine addiction_Homo sapiens_hsa050310.49091939
110Tyrosine metabolism_Homo sapiens_hsa003500.48443357
111Vitamin digestion and absorption_Homo sapiens_hsa049770.48380089
112Viral carcinogenesis_Homo sapiens_hsa052030.48007808
113Other glycan degradation_Homo sapiens_hsa005110.47366753
114Epstein-Barr virus infection_Homo sapiens_hsa051690.46733467
115Protein export_Homo sapiens_hsa030600.46264878
116Hepatitis B_Homo sapiens_hsa051610.46212676
117Glucagon signaling pathway_Homo sapiens_hsa049220.45179755
118Inositol phosphate metabolism_Homo sapiens_hsa005620.44930206
119Wnt signaling pathway_Homo sapiens_hsa043100.44810088
120Antigen processing and presentation_Homo sapiens_hsa046120.44578443
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.43518214
122Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41472911
123Cysteine and methionine metabolism_Homo sapiens_hsa002700.39835281
124Pathways in cancer_Homo sapiens_hsa052000.39445535
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38846397
126Primary immunodeficiency_Homo sapiens_hsa053400.38304451
127Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37421633
128Dorso-ventral axis formation_Homo sapiens_hsa043200.37106505
129Proteoglycans in cancer_Homo sapiens_hsa052050.35871209
130GnRH signaling pathway_Homo sapiens_hsa049120.35014083
131Sulfur relay system_Homo sapiens_hsa041220.34292504
132Phenylalanine metabolism_Homo sapiens_hsa003600.33569766
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33129186
134Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.32330518
135MAPK signaling pathway_Homo sapiens_hsa040100.32179617
136Mismatch repair_Homo sapiens_hsa034300.30954264
137Selenocompound metabolism_Homo sapiens_hsa004500.30301837
138One carbon pool by folate_Homo sapiens_hsa006700.29905483
139Notch signaling pathway_Homo sapiens_hsa043300.29567098
140Legionellosis_Homo sapiens_hsa051340.28243811
141Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28151679
142Vascular smooth muscle contraction_Homo sapiens_hsa042700.27968535
143Basal cell carcinoma_Homo sapiens_hsa052170.27729994
144HTLV-I infection_Homo sapiens_hsa051660.26069700
145Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25992752
146Dopaminergic synapse_Homo sapiens_hsa047280.25181638
147Regulation of autophagy_Homo sapiens_hsa041400.24993810
148Neurotrophin signaling pathway_Homo sapiens_hsa047220.23553506
149Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22210560
150Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21025767
151Influenza A_Homo sapiens_hsa051640.20343112
152Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.20116872
153Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19648419
154Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17659636
155Fatty acid biosynthesis_Homo sapiens_hsa000610.17470898
156Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.12911867
157Lysosome_Homo sapiens_hsa041420.12830286
158SNARE interactions in vesicular transport_Homo sapiens_hsa041300.11617928

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