CALHM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.03255987
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.03255987
3antigen processing and presentation of endogenous antigen (GO:0019883)5.94680920
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.79430685
5positive regulation of gamma-delta T cell activation (GO:0046645)5.77596078
6regulation of B cell receptor signaling pathway (GO:0050855)5.39597640
7positive regulation of B cell differentiation (GO:0045579)4.70514091
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.68270071
9B cell receptor signaling pathway (GO:0050853)4.63987749
10regulation of B cell differentiation (GO:0045577)4.58119032
11regulation of interferon-beta biosynthetic process (GO:0045357)4.46382821
12regulation of gamma-delta T cell differentiation (GO:0045586)4.39035447
13antigen processing and presentation via MHC class Ib (GO:0002475)4.32476235
14negative regulation of phagocytosis (GO:0050765)4.04771716
15regulation of gamma-delta T cell activation (GO:0046643)3.99605874
16response to peptidoglycan (GO:0032494)3.97759146
17immunoglobulin mediated immune response (GO:0016064)3.76137334
18detection of other organism (GO:0098543)3.64514110
19positive thymic T cell selection (GO:0045059)3.58071356
20regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.55348101
21barbed-end actin filament capping (GO:0051016)3.53481530
22detection of bacterium (GO:0016045)3.53187790
23regulation of mast cell degranulation (GO:0043304)3.47774189
24negative regulation of erythrocyte differentiation (GO:0045647)3.45608166
25Arp2/3 complex-mediated actin nucleation (GO:0034314)3.44570584
26detection of molecule of bacterial origin (GO:0032490)3.42994683
27defense response to protozoan (GO:0042832)3.41025645
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.39174673
29positive regulation by organism of defense response of other organism involved in symbiotic interact3.39174673
30modulation by symbiont of host immune response (GO:0052553)3.39174673
31positive regulation by symbiont of host defense response (GO:0052509)3.39174673
32modulation by symbiont of host defense response (GO:0052031)3.39174673
33modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.39174673
34detection of external biotic stimulus (GO:0098581)3.38872098
35mature B cell differentiation (GO:0002335)3.35183313
36regulation of interleukin-12 biosynthetic process (GO:0045075)3.34992020
37negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.34717554
38negative regulation of cell killing (GO:0031342)3.34717554
39definitive hemopoiesis (GO:0060216)3.33313969
40positive regulation of interferon-alpha production (GO:0032727)3.30658895
41regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.29668711
42regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.28221667
43tolerance induction (GO:0002507)3.28023382
44response to protozoan (GO:0001562)3.21967977
45myeloid dendritic cell activation (GO:0001773)3.21685555
46negative thymic T cell selection (GO:0045060)3.21322684
47regulation of interferon-alpha production (GO:0032647)3.18734814
48granulocyte activation (GO:0036230)3.16943847
49ribosomal small subunit assembly (GO:0000028)3.16496151
50regulation of mast cell activation involved in immune response (GO:0033006)3.16156972
51negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.15654594
52negative regulation of interleukin-12 production (GO:0032695)3.15369228
53response to interleukin-15 (GO:0070672)3.14742741
54negative regulation of granulocyte differentiation (GO:0030853)3.14215141
55regulation of leukocyte degranulation (GO:0043300)3.13903406
56neutrophil activation (GO:0042119)3.12214433
57negative T cell selection (GO:0043383)3.11490427
58cellular response to zinc ion (GO:0071294)3.10242304
59T cell homeostasis (GO:0043029)3.08921483
60regulation of T cell receptor signaling pathway (GO:0050856)3.08819303
61regulation of myeloid leukocyte mediated immunity (GO:0002886)3.07930089
62B cell mediated immunity (GO:0019724)3.06411434
63lipopolysaccharide-mediated signaling pathway (GO:0031663)3.06021917
64pinocytosis (GO:0006907)3.05815121
65megakaryocyte development (GO:0035855)3.05675085
66viral transcription (GO:0019083)3.04465390
67myeloid cell activation involved in immune response (GO:0002275)3.02337819
68mature B cell differentiation involved in immune response (GO:0002313)2.99051652
69myeloid dendritic cell differentiation (GO:0043011)2.98441012
70negative regulation of leukocyte mediated immunity (GO:0002704)2.98323277
71thymic T cell selection (GO:0045061)2.97566664
72positive regulation of natural killer cell differentiation (GO:0032825)2.97394894
73JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.96750343
74germinal center formation (GO:0002467)2.95622577
75NIK/NF-kappaB signaling (GO:0038061)2.94377154
76positive regulation of mast cell activation (GO:0033005)2.93392842
77detection of biotic stimulus (GO:0009595)2.91155083
78response to type I interferon (GO:0034340)2.89142371
79positive regulation of antigen processing and presentation (GO:0002579)2.88016217
80lymphocyte homeostasis (GO:0002260)2.87337388
81interferon-gamma production (GO:0032609)2.86345648
82translational termination (GO:0006415)2.84445195
83regulation of T-helper 2 cell differentiation (GO:0045628)2.84123022
84regulation of mast cell activation (GO:0033003)2.83943838
85negative regulation of lymphocyte mediated immunity (GO:0002707)2.83478712
86type I interferon signaling pathway (GO:0060337)2.82890009
87cellular response to type I interferon (GO:0071357)2.82890009
88antigen receptor-mediated signaling pathway (GO:0050851)2.82825205
89response to interferon-alpha (GO:0035455)2.82531527
90regulation of type I interferon-mediated signaling pathway (GO:0060338)2.82112334
91positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.81499014
92regulation of tolerance induction (GO:0002643)2.81211739
93amino sugar catabolic process (GO:0046348)2.80786006
94T cell migration (GO:0072678)2.80294616
95negative regulation of stress fiber assembly (GO:0051497)2.80079614
96interferon-gamma-mediated signaling pathway (GO:0060333)2.79088373
97regulation of erythrocyte differentiation (GO:0045646)2.78525874
98positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.78281505
99regulation of dendritic cell antigen processing and presentation (GO:0002604)2.78255927
100negative regulation of innate immune response (GO:0045824)2.78123880
101macrophage activation involved in immune response (GO:0002281)2.77914599
102positive regulation of monocyte chemotaxis (GO:0090026)2.77638598
103lymph node development (GO:0048535)2.76740004
104dendritic cell differentiation (GO:0097028)2.76713927
105regulation of macrophage chemotaxis (GO:0010758)2.76207419
106regulation of monocyte chemotaxis (GO:0090025)2.75988144
107positive regulation of lamellipodium assembly (GO:0010592)2.74853374
108negative regulation of B cell proliferation (GO:0030889)2.73512640
109regulation of mononuclear cell migration (GO:0071675)2.73457038
110neutrophil activation involved in immune response (GO:0002283)2.73448045
111positive regulation of mast cell degranulation (GO:0043306)2.73405789
112positive regulation of mast cell activation involved in immune response (GO:0033008)2.73405789
113T cell selection (GO:0045058)2.71292655
114negative regulation of cytokine production involved in immune response (GO:0002719)2.70446556
115B cell homeostasis (GO:0001782)2.69623547
116respiratory burst (GO:0045730)2.68765820
117positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.68717788
118angiogenesis involved in wound healing (GO:0060055)2.67627975
119positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.67519675
120lymphocyte chemotaxis (GO:0048247)2.67231740
121response to laminar fluid shear stress (GO:0034616)2.67050927
122leukocyte aggregation (GO:0070486)2.66863380
123regulation of T cell tolerance induction (GO:0002664)2.66702249
124regulation of T cell mediated cytotoxicity (GO:0001914)2.66629482
125cellular extravasation (GO:0045123)2.66587997
126response to host immune response (GO:0052572)2.66557728
127response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.66557728
128cellular response to interleukin-15 (GO:0071350)2.66072535
129response to muramyl dipeptide (GO:0032495)2.65876105
130negative regulation of T cell mediated immunity (GO:0002710)2.64873851
131negative regulation of nitric oxide biosynthetic process (GO:0045019)2.64114620
132mast cell activation (GO:0045576)2.63528010
133regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.63421174
134positive regulation of tumor necrosis factor production (GO:0032760)2.63294317
135regulation of macrophage cytokine production (GO:0010935)2.63010838
136macrophage activation (GO:0042116)2.61997492
137negative regulation of T cell receptor signaling pathway (GO:0050860)2.61671516
138response to host defenses (GO:0052200)2.61431147
139response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.61431147
140response to host (GO:0075136)2.61431147
141positive regulation of histone deacetylation (GO:0031065)2.60793987
142germ cell migration (GO:0008354)2.60631582
143actin nucleation (GO:0045010)2.60418296
144regulation of antigen processing and presentation (GO:0002577)2.60116001
145mannose metabolic process (GO:0006013)2.58030676
146embryonic hemopoiesis (GO:0035162)2.57691530
147regulation of lymphocyte migration (GO:2000401)2.57042004
148leukocyte homeostasis (GO:0001776)2.56870841
149regulation of granulocyte differentiation (GO:0030852)2.56217906
150regulation of natural killer cell mediated immunity (GO:0002715)2.54179934

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.89742102
2E2F7_22180533_ChIP-Seq_HELA_Human3.90850265
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.72365942
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.66376703
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.51465754
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.48648526
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.46172701
8MYC_22102868_ChIP-Seq_BL_Human3.29546258
9VDR_21846776_ChIP-Seq_THP-1_Human3.20630773
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.13623881
11SCL_19346495_ChIP-Seq_HPC-7_Human2.96616029
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.87505916
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.77618723
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.72855269
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.67548231
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.63036461
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.51957837
18MAF_26560356_Chip-Seq_TH1_Human2.48193464
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.45781241
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.41806063
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.41185830
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.37946728
23VDR_24763502_ChIP-Seq_THP-1_Human2.37165421
24MYB_26560356_Chip-Seq_TH2_Human2.31961757
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.31112871
26SPI1_23547873_ChIP-Seq_NB4_Human2.23715001
27STAT4_19710469_ChIP-ChIP_TH1__Mouse2.22387527
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.21923122
29MYB_26560356_Chip-Seq_TH1_Human2.19403854
30UTX_26944678_Chip-Seq_JUKART_Human2.19194946
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.16571196
32RUNX_20019798_ChIP-Seq_JUKART_Human2.16212678
33TCF7_22412390_ChIP-Seq_EML_Mouse2.15752393
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.12254723
35NOTCH1_21737748_ChIP-Seq_TLL_Human2.09921401
36RUNX1_22412390_ChIP-Seq_EML_Mouse2.07999242
37BRD4_27068464_Chip-Seq_AML-cells_Mouse2.04857433
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.98272334
39* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.93756849
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.85806378
41SPI1_23127762_ChIP-Seq_K562_Human1.85156412
42* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.82905774
43* ELK3_25401928_ChIP-Seq_HUVEC_Human1.82337163
44EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.80748401
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.71044074
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.62974483
47KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.62711769
48SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.62622872
49* KDM2B_26808549_Chip-Seq_DND41_Human1.62458166
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.61983845
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.59374528
52GATA1_22025678_ChIP-Seq_K562_Human1.58544955
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.58156683
54FOXM1_23109430_ChIP-Seq_U2OS_Human1.52270487
55VDR_24787735_ChIP-Seq_THP-1_Human1.50478553
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.49325593
57* MAF_26560356_Chip-Seq_TH2_Human1.48375216
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42122191
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.42091056
60CIITA_25753668_ChIP-Seq_RAJI_Human1.41471177
61GATA1_22383799_ChIP-Seq_G1ME_Mouse1.40375138
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39725331
63ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38744449
64TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36617358
65PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35657303
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.35555259
67* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34092019
68* RACK7_27058665_Chip-Seq_MCF-7_Human1.31530474
69PU_27001747_Chip-Seq_BMDM_Mouse1.31487520
70GATA3_27048872_Chip-Seq_THYMUS_Human1.30391268
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29489427
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29095828
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25145774
74* BCL6_27268052_Chip-Seq_Bcells_Human1.21619685
75* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.20234899
76GATA1_19941827_ChIP-Seq_MEL_Mouse1.18337592
77IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15631727
78CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12447220
79GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11731673
80BCOR_27268052_Chip-Seq_Bcells_Human1.11642252
81* SA1_27219007_Chip-Seq_ERYTHROID_Human1.11368604
82LXR_22292898_ChIP-Seq_THP-1_Human1.11093204
83ELF1_20517297_ChIP-Seq_JURKAT_Human1.10063670
84PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08502487
85SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07313921
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07100097
87SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06785150
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06119407
89CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04568995
90E2F4_17652178_ChIP-ChIP_JURKAT_Human1.04476295
91RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02236241
92NCOR1_26117541_ChIP-Seq_K562_Human1.01893958
93PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01254358
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01000595
95CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99994796
96Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98850695
97SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98233047
98KDM2B_26808549_Chip-Seq_JURKAT_Human0.96987128
99UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94727826
100P68_20966046_ChIP-Seq_HELA_Human0.93127993
101PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.92722452
102KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.89647919
103SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89364483
104TP63_17297297_ChIP-ChIP_HaCaT_Human0.89356122
105PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89108681
106TFEB_21752829_ChIP-Seq_HELA_Human0.88340480
107NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88311137
108GATA3_26560356_Chip-Seq_TH2_Human0.88141402
109PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87479163
110HOXB4_20404135_ChIP-ChIP_EML_Mouse0.86919468
111GATA2_21666600_ChIP-Seq_HMVEC_Human0.86833223
112TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86127840
113KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84293240
114CTCF_21964334_ChIP-Seq_BJAB-B_Human0.82533146
115SPI1_20517297_ChIP-Seq_HL60_Human0.81405236
116MYC_18555785_ChIP-Seq_MESCs_Mouse0.80495621
117CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80236773
118* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79508412
119GATA1_19941826_ChIP-Seq_K562_Human0.78232557
120CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77571335
121GATA2_19941826_ChIP-Seq_K562_Human0.77280223
122CTCF_27219007_Chip-Seq_ERYTHROID_Human0.76504419
123PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76162020

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.99618580
2MP0000685_abnormal_immune_system3.19456322
3MP0001800_abnormal_humoral_immune3.02996507
4MP0001790_abnormal_immune_system2.90086985
5MP0005387_immune_system_phenotype2.90086985
6MP0002396_abnormal_hematopoietic_system2.86264916
7MP0003303_peritoneal_inflammation2.81950376
8MP0005671_abnormal_response_to2.78510446
9MP0002452_abnormal_antigen_presenting2.68547108
10MP0005000_abnormal_immune_tolerance2.63307718
11MP0003436_decreased_susceptibility_to2.55129031
12MP0002723_abnormal_immune_serum2.42652333
13MP0003300_gastrointestinal_ulcer2.41104806
14MP0002420_abnormal_adaptive_immunity2.39763186
15MP0001819_abnormal_immune_cell2.35785709
16MP0002398_abnormal_bone_marrow2.29405607
17MP0002166_altered_tumor_susceptibility2.26420254
18MP0003763_abnormal_thymus_physiology2.22473163
19MP0002419_abnormal_innate_immunity2.22278482
20MP0005025_abnormal_response_to2.19795091
21MP0004808_abnormal_hematopoietic_stem2.15998110
22MP0000716_abnormal_immune_system2.07409493
23MP0005464_abnormal_platelet_physiology2.06666734
24MP0009785_altered_susceptibility_to2.05935807
25MP0002405_respiratory_system_inflammati1.99521283
26MP0000689_abnormal_spleen_morphology1.99191027
27MP0001873_stomach_inflammation1.97114105
28MP0002722_abnormal_immune_system1.89754672
29MP0003172_abnormal_lysosome_physiology1.86195608
30MP0001853_heart_inflammation1.85581946
31MP0006082_CNS_inflammation1.83593591
32MP0002148_abnormal_hypersensitivity_rea1.80726729
33MP0000465_gastrointestinal_hemorrhage1.79999144
34MP0002429_abnormal_blood_cell1.79411775
35MP0002933_joint_inflammation1.78991542
36MP0008438_abnormal_cutaneous_collagen1.78143543
37MP0003724_increased_susceptibility_to1.77756159
38MP0009278_abnormal_bone_marrow1.74735411
39MP0005058_abnormal_lysosome_morphology1.74480747
40MP0009333_abnormal_splenocyte_physiolog1.71309956
41MP0001545_abnormal_hematopoietic_system1.69202654
42MP0005397_hematopoietic_system_phenotyp1.69202654
43MP0010155_abnormal_intestine_physiology1.68999130
44MP0003279_aneurysm1.68857545
45MP0008260_abnormal_autophagy1.67577670
46MP0001542_abnormal_bone_strength1.65667771
47MP0004947_skin_inflammation1.63908103
48MP0002006_tumorigenesis1.61030527
49MP0005174_abnormal_tail_pigmentation1.57938851
50MP0000703_abnormal_thymus_morphology1.55282653
51MP0001845_abnormal_inflammatory_respons1.54130295
52MP0004510_myositis1.49788237
53MP0001533_abnormal_skeleton_physiology1.49219075
54MP0003566_abnormal_cell_adhesion1.47879910
55MP0010352_gastrointestinal_tract_polyps1.42800459
56MP0000604_amyloidosis1.32694063
57MP0003828_pulmonary_edema1.32509594
58MP0004883_abnormal_blood_vessel1.31052408
59MP0000858_altered_metastatic_potential1.27190504
60MP0005164_abnormal_response_to1.25176010
61MP0000490_abnormal_crypts_of1.23480664
62MP0003866_abnormal_defecation1.21476638
63MP0001958_emphysema1.20283125
64MP0005023_abnormal_wound_healing1.19498619
65MP0000343_altered_response_to1.19011357
66MP0000569_abnormal_digit_pigmentation1.17295000
67MP0005451_abnormal_body_composition1.16009561
68MP0008469_abnormal_protein_level1.14666780
69MP0005075_abnormal_melanosome_morpholog1.13709570
70MP0003448_altered_tumor_morphology1.12161241
71MP0003045_fibrosis1.07635697
72MP0003705_abnormal_hypodermis_morpholog1.07408518
73MP0005310_abnormal_salivary_gland1.05932844
74MP0010307_abnormal_tumor_latency0.99329496
75MP0005166_decreased_susceptibility_to0.99197080
76MP0003091_abnormal_cell_migration0.97639655
77MP0002877_abnormal_melanocyte_morpholog0.96388713
78MP0000767_abnormal_smooth_muscle0.95611037
79MP0008007_abnormal_cellular_replicative0.95441942
80MP0002998_abnormal_bone_remodeling0.95073037
81MP0001879_abnormal_lymphatic_vessel0.92837756
82MP0005257_abnormal_intraocular_pressure0.92465561
83MP0006054_spinal_hemorrhage0.90705918
84MP0002019_abnormal_tumor_incidence0.90163545
85MP0003191_abnormal_cellular_cholesterol0.88955424
86MP0005076_abnormal_cell_differentiation0.87821252
87MP0005390_skeleton_phenotype0.85230168
88MP0010368_abnormal_lymphatic_system0.83375002
89MP0002095_abnormal_skin_pigmentation0.83341396
90MP0003690_abnormal_glial_cell0.82383542
91MP0001851_eye_inflammation0.78691195
92MP0000015_abnormal_ear_pigmentation0.78641905
93MP0000249_abnormal_blood_vessel0.78570065
94MP0003183_abnormal_peptide_metabolism0.76594622
95MP0005165_increased_susceptibility_to0.74785715
96MP0003806_abnormal_nucleotide_metabolis0.74320754
97MP0001849_ear_inflammation0.72443105
98MP0000371_diluted_coat_color0.71564638
99MP0002254_reproductive_system_inflammat0.70457078
100MP0005595_abnormal_vascular_smooth0.70366920
101MP0008057_abnormal_DNA_replication0.69780327
102MP0001243_abnormal_dermal_layer0.69680300
103MP0003075_altered_response_to0.69431548
104MP0004858_abnormal_nervous_system0.69387392
105MP0002132_abnormal_respiratory_system0.69212253
106MP0009763_increased_sensitivity_to0.67965854
107MP0005275_abnormal_skin_tensile0.67567731
108MP0002928_abnormal_bile_duct0.67447861
109MP0009840_abnormal_foam_cell0.66704670
110MP0002060_abnormal_skin_morphology0.66398132
111MP0003795_abnormal_bone_structure0.66011215
112MP0005508_abnormal_skeleton_morphology0.65939866
113MP0000920_abnormal_myelination0.64661600
114MP0003077_abnormal_cell_cycle0.64327094
115MP0005503_abnormal_tendon_morphology0.63942380
116MP0009764_decreased_sensitivity_to0.63931272
117MP0009384_cardiac_valve_regurgitation0.61700925
118MP0002133_abnormal_respiratory_system0.61400077
119MP0005388_respiratory_system_phenotype0.61400077
120MP0000733_abnormal_muscle_development0.60756791
121MP0002128_abnormal_blood_circulation0.57631434
122MP0001663_abnormal_digestive_system0.57616697

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)4.42218918
2Abnormality of liposaccharide metabolism (HP:0010968)4.42218918
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.42218918
4Chronic otitis media (HP:0000389)4.23887002
5Agammaglobulinemia (HP:0004432)4.21172381
6Recurrent abscess formation (HP:0002722)4.18106177
7Elevated erythrocyte sedimentation rate (HP:0003565)4.09645530
8IgM deficiency (HP:0002850)3.97410724
9Cellulitis (HP:0100658)3.91836438
10Recurrent viral infections (HP:0004429)3.80224469
11Recurrent bacterial skin infections (HP:0005406)3.73567399
12Myositis (HP:0100614)3.73424813
13Recurrent bronchitis (HP:0002837)3.71271791
14Inflammation of the large intestine (HP:0002037)3.67634718
15Colitis (HP:0002583)3.66011798
16Gastrointestinal inflammation (HP:0004386)3.61694948
17Thrombocytosis (HP:0001894)3.57670957
18Eczematoid dermatitis (HP:0000976)3.57012621
19Recurrent fungal infections (HP:0002841)3.56389475
20Spontaneous hematomas (HP:0007420)3.45626921
21Abnormal delayed hypersensitivity skin test (HP:0002963)3.41613130
22Abnormality of the nasal mucosa (HP:0000433)3.37372693
23Panhypogammaglobulinemia (HP:0003139)3.33891239
24Nasal polyposis (HP:0100582)3.22953997
25Meningitis (HP:0001287)3.19861889
26Hematochezia (HP:0002573)3.18032903
27Gastrointestinal stroma tumor (HP:0100723)3.16537254
28Recurrent cutaneous fungal infections (HP:0011370)3.12102486
29Chronic mucocutaneous candidiasis (HP:0002728)3.12102486
30Mediastinal lymphadenopathy (HP:0100721)3.04592806
31Recurrent skin infections (HP:0001581)3.04125319
32Emphysema (HP:0002097)2.95196736
33Increased neuronal autofluorescent lipopigment (HP:0002074)2.95184193
34Protrusio acetabuli (HP:0003179)2.93170854
35Prolonged bleeding time (HP:0003010)2.88319511
36Petechiae (HP:0000967)2.86057947
37Cerebral aneurysm (HP:0004944)2.85552168
38Aortic aneurysm (HP:0004942)2.79288308
39Premature rupture of membranes (HP:0001788)2.77477427
40Lymphopenia (HP:0001888)2.67717861
41Loss of speech (HP:0002371)2.64790065
42Stomatitis (HP:0010280)2.64381035
43Vasculitis (HP:0002633)2.64044683
44Abnormality of cells of the lymphoid lineage (HP:0012140)2.62295310
45Abnormality of T cell physiology (HP:0011840)2.61370903
46Spondylolisthesis (HP:0003302)2.58538449
47Gastrointestinal infarctions (HP:0005244)2.58069116
48Optic neuritis (HP:0100653)2.57776367
49Retrobulbar optic neuritis (HP:0100654)2.57776367
50Interstitial pulmonary disease (HP:0006530)2.56959641
51Pustule (HP:0200039)2.56920211
52Verrucae (HP:0200043)2.53707921
53Papilloma (HP:0012740)2.53707921
54Obstructive lung disease (HP:0006536)2.52310166
55Chronic obstructive pulmonary disease (HP:0006510)2.52310166
56Systemic lupus erythematosus (HP:0002725)2.50105551
57Purpura (HP:0000979)2.49588945
58Abnormality of T cells (HP:0002843)2.47545983
59Epistaxis (HP:0000421)2.44975821
60Aortic dissection (HP:0002647)2.43172950
61Abnormal platelet function (HP:0011869)2.41298055
62Impaired platelet aggregation (HP:0003540)2.41298055
63Amyloidosis (HP:0011034)2.40589475
64Abnormality of macrophages (HP:0004311)2.39707972
65Periodontitis (HP:0000704)2.38611040
66Dysostosis multiplex (HP:0000943)2.37936283
67Chest pain (HP:0100749)2.37045142
68Increased density of long bones (HP:0006392)2.36133345
69Peritonitis (HP:0002586)2.34100664
70Orchitis (HP:0100796)2.33735758
71Osteomyelitis (HP:0002754)2.32953664
72Abnormality of the fingertips (HP:0001211)2.31377807
73Arterial thrombosis (HP:0004420)2.30710091
74Chronic sinusitis (HP:0011109)2.29705578
75Recurrent gram-negative bacterial infections (HP:0005420)2.25389506
76Abnormality of the peritoneum (HP:0002585)2.23856281
77Urticaria (HP:0001025)2.21848548
78Restrictive lung disease (HP:0002091)2.19481128
79Hepatosplenomegaly (HP:0001433)2.16362893
80Chronic diarrhea (HP:0002028)2.14809518
81Recurrent lower respiratory tract infections (HP:0002783)2.14348406
82Increased serum ferritin (HP:0003281)2.14288479
83Fatigue (HP:0012378)2.12341552
84Pulmonary infiltrates (HP:0002113)2.12239705
85Gingival bleeding (HP:0000225)2.10177119
86Recurrent sinusitis (HP:0011108)2.09115536
87Hemoptysis (HP:0002105)2.08891654
88T lymphocytopenia (HP:0005403)2.08604053
89Mucopolysacchariduria (HP:0008155)2.08557407
90Urinary glycosaminoglycan excretion (HP:0003541)2.08557407
91Leukocytosis (HP:0001974)2.06490793
92Encephalitis (HP:0002383)2.05241416
93Increased cerebral lipofuscin (HP:0011813)2.04290630
94IgA deficiency (HP:0002720)2.03662391
95Abnormal platelet volume (HP:0011876)2.03427632
96Increased IgE level (HP:0003212)2.01744968
97Axonal loss (HP:0003447)2.01232515
98Abnormality of T cell number (HP:0011839)2.00817711
99Vacuolated lymphocytes (HP:0001922)2.00178662
100Joint stiffness (HP:0001387)1.99952034
101Skin ulcer (HP:0200042)1.99375248
102Gingivitis (HP:0000230)1.99207378
103Asymmetric septal hypertrophy (HP:0001670)1.97622535
104Hypergammaglobulinemia (HP:0010702)1.95962811
105Abnormality of mucopolysaccharide metabolism (HP:0011020)1.95538057
106Abnormality of polysaccharide metabolism (HP:0011012)1.95538057
107Abnormality of glycosaminoglycan metabolism (HP:0004371)1.95538057
108Mitral valve prolapse (HP:0001634)1.95245644
109Vertebral compression fractures (HP:0002953)1.93285342
110Osteolytic defects of the hand bones (HP:0009699)1.92719893
111Osteolytic defects of the phalanges of the hand (HP:0009771)1.92719893
112Cervical subluxation (HP:0003308)1.92296424
113Reticulocytopenia (HP:0001896)1.92257520
114B lymphocytopenia (HP:0010976)1.91251394
115Abnormality of B cell number (HP:0010975)1.91251394
116J-shaped sella turcica (HP:0002680)1.90867673
117Increased IgM level (HP:0003496)1.90699531
118Dilatation of the ascending aorta (HP:0005111)1.89332179
119Myocardial infarction (HP:0001658)1.89236466
120Autoimmune thrombocytopenia (HP:0001973)1.89051092
121Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.87858346
122Increased variability in muscle fiber diameter (HP:0003557)1.87462976
123Keratoconjunctivitis sicca (HP:0001097)1.87208111
124Recurrent pneumonia (HP:0006532)1.87000412
125Bicuspid aortic valve (HP:0001647)1.86537023
126Granulocytopenia (HP:0001913)1.86011675
127Glomerulopathy (HP:0100820)1.85159881
128Abnormality of the vasculature of the conjunctiva (HP:0008054)1.84872769
129Acrocyanosis (HP:0001063)1.84852700
130Polycythemia (HP:0001901)1.81650677
131Ankle contracture (HP:0006466)1.80208445
132Upper motor neuron abnormality (HP:0002127)1.79617835
133Abnormality of skeletal muscle fiber size (HP:0012084)1.79121850
134Increased connective tissue (HP:0009025)1.78642392
135Thin bony cortex (HP:0002753)1.77149283
136Episodic fever (HP:0001954)1.77072350
137Slender build (HP:0001533)1.77060382

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.65788017
2KIT2.82400425
3ERN12.76979652
4TGFBR22.76195792
5EEF2K2.75968503
6BLK2.73875547
7CSF1R2.54010597
8PRPF4B2.43087903
9TRIB32.42791539
10TYK22.27241100
11ZAP702.18432199
12JAK32.15200490
13MAP3K132.04225256
14TBK11.92652648
15BTK1.90631542
16FLT31.89219116
17PKN21.88289730
18STK101.88137931
19LRRK21.83890076
20MAP3K111.69128410
21TESK11.64153301
22TEC1.63563726
23SYK1.62875904
24JAK11.59090154
25MAP3K101.56993245
26MAP3K31.55441204
27IRAK41.51567513
28TXK1.49552214
29KDR1.47269855
30GRK61.46794720
31TTN1.46181927
32RIPK41.43421504
33CSK1.43146985
34IKBKB1.41395400
35ITK1.40765493
36PIM21.39312615
37LCK1.34671161
38HCK1.30774066
39TAOK31.28161722
40SCYL21.27423774
41FES1.26963747
42DDR21.26830577
43MAP2K31.24880027
44SIK21.24316649
45CDC42BPA1.23195981
46NME21.20926330
47TAOK21.17309672
48IKBKE1.17191558
49RPS6KA41.14278416
50LYN1.13867495
51MATK1.13633130
52MAP3K141.13356207
53MYLK1.13220761
54FGFR41.12692311
55TGFBR11.07450543
56EPHB11.06861071
57MAP3K61.04692453
58GRK71.01167768
59TAOK10.98745457
60IRAK30.97975535
61TIE10.95823496
62CAMK1D0.95389824
63PIM10.95001401
64SMG10.94139551
65PAK40.93740179
66CDK120.91505735
67MAP3K10.90705455
68SIK30.85724526
69MAP3K70.84803982
70SIK10.83167560
71PTK60.81500393
72MOS0.80252252
73MARK30.78500962
74LIMK10.77061104
75FGFR30.76962523
76CLK10.74656192
77CDK40.73297902
78PDPK10.73145954
79ABL20.71536758
80NEK20.69923652
81RIPK10.69850020
82PRKD20.67986574
83TRPM70.66957539
84CHUK0.66659643
85PIK3CG0.65365826
86RPS6KA20.64994876
87CAMKK20.64098309
88PDK10.63918775
89NLK0.61483323
90PTK2B0.60714565
91FGR0.60247726
92STK380.58520061
93MAPKAPK30.56948847
94CDK60.55754499
95JAK20.55719835
96BMPR20.55516559
97RPS6KB20.53832859
98PAK20.53121444
99ARAF0.52112108
100KSR20.50409800
101TNK20.50317463
102MAPK70.49976609
103CDK90.49712514
104EPHA30.48824710
105MAPK40.48743354
106DMPK0.47970768
107MAPK120.47680866
108FYN0.47580264
109PDGFRB0.47164497
110RAF10.45808299
111MAPKAPK20.44711014
112PRKG20.43083260
113PRKCQ0.42651972
114TESK20.42608415
115HIPK20.42553958
116CAMK1G0.42363289
117RPS6KA60.41869004
118MAP2K20.41097528
119CAMKK10.38974756
120MAPK110.36692334
121ABL10.36007690
122EGFR0.35913294
123MAP3K80.35866831
124PDGFRA0.35418350
125MARK20.34854983
126NEK90.33677228
127PRKD10.33533352
128RPS6KL10.33429033
129RPS6KC10.33429033
130STK40.33266196
131ADRBK20.32606865
132PRKCH0.32555875

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.34373381
2B cell receptor signaling pathway_Homo sapiens_hsa046623.22130410
3Leishmaniasis_Homo sapiens_hsa051402.60231163
4Antigen processing and presentation_Homo sapiens_hsa046122.45938041
5Osteoclast differentiation_Homo sapiens_hsa043802.27428022
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.27004228
7Autoimmune thyroid disease_Homo sapiens_hsa053202.23365227
8Hematopoietic cell lineage_Homo sapiens_hsa046402.14466803
9Measles_Homo sapiens_hsa051622.06455064
10Glycosaminoglycan degradation_Homo sapiens_hsa005311.98045934
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.97884953
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.91324935
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.83767519
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.80867923
15Other glycan degradation_Homo sapiens_hsa005111.74046586
16DNA replication_Homo sapiens_hsa030301.70494195
17Rheumatoid arthritis_Homo sapiens_hsa053231.69339153
18T cell receptor signaling pathway_Homo sapiens_hsa046601.67587081
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.67168203
20Staphylococcus aureus infection_Homo sapiens_hsa051501.66493891
21Type I diabetes mellitus_Homo sapiens_hsa049401.58342993
22Pertussis_Homo sapiens_hsa051331.56512703
23Shigellosis_Homo sapiens_hsa051311.55246728
24Ribosome_Homo sapiens_hsa030101.54918576
25Toxoplasmosis_Homo sapiens_hsa051451.52832722
26Chronic myeloid leukemia_Homo sapiens_hsa052201.48904169
27Malaria_Homo sapiens_hsa051441.48497829
28Herpes simplex infection_Homo sapiens_hsa051681.46949232
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.45907441
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.45800298
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.44007896
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.42965500
33Platelet activation_Homo sapiens_hsa046111.42116880
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.40750742
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.39961031
36Acute myeloid leukemia_Homo sapiens_hsa052211.39004690
37Base excision repair_Homo sapiens_hsa034101.37310277
38Tuberculosis_Homo sapiens_hsa051521.37281733
39Apoptosis_Homo sapiens_hsa042101.35467327
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.33777164
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33239461
42Hepatitis B_Homo sapiens_hsa051611.30652766
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.23405037
44Chemokine signaling pathway_Homo sapiens_hsa040621.19258965
45NOD-like receptor signaling pathway_Homo sapiens_hsa046211.18045764
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16676732
47Influenza A_Homo sapiens_hsa051641.16381013
48Pancreatic cancer_Homo sapiens_hsa052121.16041218
49Lysosome_Homo sapiens_hsa041421.12977746
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11650539
51Small cell lung cancer_Homo sapiens_hsa052221.10279455
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.09094552
53TNF signaling pathway_Homo sapiens_hsa046681.08643278
54Viral myocarditis_Homo sapiens_hsa054161.08441763
55Legionellosis_Homo sapiens_hsa051341.04075209
56Mismatch repair_Homo sapiens_hsa034301.00262262
57Notch signaling pathway_Homo sapiens_hsa043300.99115481
58HTLV-I infection_Homo sapiens_hsa051660.98852482
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95903885
60Epstein-Barr virus infection_Homo sapiens_hsa051690.93555041
61Allograft rejection_Homo sapiens_hsa053300.93065011
62Viral carcinogenesis_Homo sapiens_hsa052030.92901841
63Salmonella infection_Homo sapiens_hsa051320.92042280
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.91715247
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91259675
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91192172
67VEGF signaling pathway_Homo sapiens_hsa043700.85149497
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83407762
69Colorectal cancer_Homo sapiens_hsa052100.80798712
70p53 signaling pathway_Homo sapiens_hsa041150.80415885
71Non-small cell lung cancer_Homo sapiens_hsa052230.80336061
72Bladder cancer_Homo sapiens_hsa052190.78935962
73Caffeine metabolism_Homo sapiens_hsa002320.75886628
74Graft-versus-host disease_Homo sapiens_hsa053320.74114385
75Non-homologous end-joining_Homo sapiens_hsa034500.71862546
76Focal adhesion_Homo sapiens_hsa045100.71264027
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71012682
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69985335
79Prion diseases_Homo sapiens_hsa050200.69320915
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69006363
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.68374146
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67160356
83Proteoglycans in cancer_Homo sapiens_hsa052050.66869395
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63576578
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62611705
86MicroRNAs in cancer_Homo sapiens_hsa052060.60784018
87Homologous recombination_Homo sapiens_hsa034400.58818967
88Hepatitis C_Homo sapiens_hsa051600.57594092
89Systemic lupus erythematosus_Homo sapiens_hsa053220.56890880
90Renal cell carcinoma_Homo sapiens_hsa052110.55138399
91Amoebiasis_Homo sapiens_hsa051460.53736806
92Galactose metabolism_Homo sapiens_hsa000520.53103329
93Complement and coagulation cascades_Homo sapiens_hsa046100.52810112
94HIF-1 signaling pathway_Homo sapiens_hsa040660.51927434
95ECM-receptor interaction_Homo sapiens_hsa045120.50151949
96N-Glycan biosynthesis_Homo sapiens_hsa005100.49551080
97Insulin resistance_Homo sapiens_hsa049310.47746008
98African trypanosomiasis_Homo sapiens_hsa051430.47731958
99Lysine degradation_Homo sapiens_hsa003100.46167209
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45929544
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44720523
102Prolactin signaling pathway_Homo sapiens_hsa049170.44391544
103Asthma_Homo sapiens_hsa053100.43519549
104Pathways in cancer_Homo sapiens_hsa052000.43353945
105Endocytosis_Homo sapiens_hsa041440.42953024
106GnRH signaling pathway_Homo sapiens_hsa049120.42438623
107Spliceosome_Homo sapiens_hsa030400.42426447
108Pentose phosphate pathway_Homo sapiens_hsa000300.42176301
109Adherens junction_Homo sapiens_hsa045200.40954530
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.37933388
111Glioma_Homo sapiens_hsa052140.36805845
112Vibrio cholerae infection_Homo sapiens_hsa051100.34613652
113Rap1 signaling pathway_Homo sapiens_hsa040150.32990107
114Phagosome_Homo sapiens_hsa041450.32450890
115mTOR signaling pathway_Homo sapiens_hsa041500.31893126
116Renin-angiotensin system_Homo sapiens_hsa046140.31882581
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31626802
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31625813
119Nucleotide excision repair_Homo sapiens_hsa034200.31172575
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.30816639
121Collecting duct acid secretion_Homo sapiens_hsa049660.30400093
122MAPK signaling pathway_Homo sapiens_hsa040100.30326035

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »