CALCA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular biogenic amine biosynthetic process (GO:0042401)8.06481326
2amine biosynthetic process (GO:0009309)7.56205354
3negative regulation of dendrite morphogenesis (GO:0050774)7.52220217
4peripheral nervous system neuron development (GO:0048935)7.31221923
5negative regulation of myotube differentiation (GO:0010832)7.29046490
6response to water (GO:0009415)7.12638355
7mammary gland alveolus development (GO:0060749)7.10222365
8cellular response to nicotine (GO:0071316)6.95058222
9bone remodeling (GO:0046849)6.80381738
10nerve growth factor signaling pathway (GO:0038180)6.78509256
11indole-containing compound metabolic process (GO:0042430)6.32127048
12cell migration in hindbrain (GO:0021535)5.86558191
13complement activation, classical pathway (GO:0006958)5.68891734
14Rap protein signal transduction (GO:0032486)5.64030179
15sympathetic nervous system development (GO:0048485)5.49815726
16cellular response to ATP (GO:0071318)5.48777731
17neurofilament cytoskeleton organization (GO:0060052)5.27596023
18cranial nerve development (GO:0021545)5.24026867
19negative regulation of heart rate (GO:0010459)5.22906405
20signal peptide processing (GO:0006465)5.11957571
21phenol-containing compound biosynthetic process (GO:0046189)5.07223726
22dopamine biosynthetic process (GO:0042416)4.96773392
23negative regulation of complement activation (GO:0045916)4.95365413
24aromatic amino acid family metabolic process (GO:0009072)4.94753194
25toxin metabolic process (GO:0009404)4.84105339
26negative regulation of dendrite development (GO:2000171)4.79063685
27positive regulation of action potential (GO:0045760)4.73550898
28mitochondrion transport along microtubule (GO:0047497)4.73318370
29establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.73318370
30establishment of mitochondrion localization (GO:0051654)4.67630448
31surfactant homeostasis (GO:0043129)4.60879466
32negative regulation of protein activation cascade (GO:2000258)4.55170097
33detection of mechanical stimulus involved in sensory perception (GO:0050974)4.54864205
34positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.54833061
35positive regulation of synaptic transmission, GABAergic (GO:0032230)4.48984763
36positive regulation of steroid hormone secretion (GO:2000833)4.48138051
37neuronal action potential (GO:0019228)4.47601843
38ER overload response (GO:0006983)4.42459883
39mechanoreceptor differentiation (GO:0042490)4.42127532
40complement activation (GO:0006956)4.41816059
41tachykinin receptor signaling pathway (GO:0007217)4.38643435
42antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.36179196
43negative regulation of striated muscle cell differentiation (GO:0051154)4.27978910
44response to nerve growth factor (GO:1990089)4.22857660
45cellular response to nerve growth factor stimulus (GO:1990090)4.22857660
46nerve development (GO:0021675)4.17900083
47negative regulation of homotypic cell-cell adhesion (GO:0034111)4.12218792
48antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.97716773
49regulation of glucocorticoid secretion (GO:2000849)3.96310369
50negative regulation of humoral immune response (GO:0002921)3.93124524
51negative regulation of epithelial to mesenchymal transition (GO:0010719)3.88005820
52proline transport (GO:0015824)3.87204269
53neuron fate specification (GO:0048665)3.85937896
54regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.85891390
55negative regulation of anoikis (GO:2000811)3.82346139
56response to acidic pH (GO:0010447)3.81013526
57regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.77666302
58membrane depolarization during action potential (GO:0086010)3.76706776
59positive regulation of respiratory burst (GO:0060267)3.76695103
60innervation (GO:0060384)3.76626380
61regulation of bile acid biosynthetic process (GO:0070857)3.76300394
62chemical homeostasis within a tissue (GO:0048875)3.73655461
63retinal ganglion cell axon guidance (GO:0031290)3.73142810
64positive regulation of protein autophosphorylation (GO:0031954)3.70564336
65amyloid precursor protein catabolic process (GO:0042987)3.65218916
66negative regulation of microtubule polymerization (GO:0031115)3.63920107
67auditory receptor cell differentiation (GO:0042491)3.63812213
68negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.63415584
69positive regulation of macroautophagy (GO:0016239)3.62411067
70cell communication involved in cardiac conduction (GO:0086065)3.56976458
71neuronal action potential propagation (GO:0019227)3.55603938
72synaptic vesicle maturation (GO:0016188)3.55501848
73branching involved in labyrinthine layer morphogenesis (GO:0060670)3.48998767
74protein activation cascade (GO:0072376)3.48309359
75nephron tubule formation (GO:0072079)3.43460246
76positive regulation of digestive system process (GO:0060456)3.42716016
77bundle of His cell to Purkinje myocyte communication (GO:0086069)3.41929777
78Golgi transport vesicle coating (GO:0048200)3.41796057
79COPI coating of Golgi vesicle (GO:0048205)3.41796057
80iron coordination entity transport (GO:1901678)3.40242898
81regulation of corticosteroid hormone secretion (GO:2000846)3.39860504
82heart valve morphogenesis (GO:0003179)3.39715988
83N-acetylneuraminate metabolic process (GO:0006054)3.36153678
84positive regulation of Ras protein signal transduction (GO:0046579)3.34691312
85macroautophagy (GO:0016236)3.33606131
86regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.33449348
87negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.31901921
88alkaloid metabolic process (GO:0009820)3.30803362
89negative regulation of glycogen biosynthetic process (GO:0045719)3.30579277
90low-density lipoprotein particle remodeling (GO:0034374)3.30390670
91lung vasculature development (GO:0060426)3.25655122
92eye photoreceptor cell differentiation (GO:0001754)3.22060473
93photoreceptor cell differentiation (GO:0046530)3.22060473
94maintenance of gastrointestinal epithelium (GO:0030277)3.21382174
95regulation of platelet aggregation (GO:0090330)3.20954942
96regulation of action potential (GO:0098900)3.20198472
97* negative regulation of calcium ion transport into cytosol (GO:0010523)3.19787598
98regulation of respiratory burst (GO:0060263)3.18668402
99negative regulation of Ras GTPase activity (GO:0034261)3.17682963
100maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.17567733
101negative regulation of cation channel activity (GO:2001258)3.14393724
102regulation of complement activation (GO:0030449)3.14391328
1034-hydroxyproline metabolic process (GO:0019471)3.14079405
104glutamate secretion (GO:0014047)3.13816490
105regulation of synaptic vesicle exocytosis (GO:2000300)3.12991648
106catecholamine biosynthetic process (GO:0042423)3.12170030
107catechol-containing compound biosynthetic process (GO:0009713)3.12170030
108antigen processing and presentation of endogenous antigen (GO:0019883)3.10952235
109sodium ion homeostasis (GO:0055078)3.10375886
110regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.08374907
111high-density lipoprotein particle remodeling (GO:0034375)3.04137484
112sensory perception of pain (GO:0019233)3.03248738
113protein-chromophore linkage (GO:0018298)3.01565959
114regulation of short-term neuronal synaptic plasticity (GO:0048172)3.01511814
115ectodermal placode formation (GO:0060788)3.01057190
116endothelial cell chemotaxis (GO:0035767)3.00728129
117* activation of adenylate cyclase activity (GO:0007190)2.99953328
118Sertoli cell development (GO:0060009)2.99817289
119toxin transport (GO:1901998)2.98093069
120regulation of protein activation cascade (GO:2000257)2.97751581
121* response to pain (GO:0048265)2.97228184
122chemosensory behavior (GO:0007635)2.97157444
123protein retention in ER lumen (GO:0006621)2.96333691
124adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.96249244
125cellular sodium ion homeostasis (GO:0006883)2.95064749
126positive regulation of cell size (GO:0045793)2.94163908
127protein maturation by protein folding (GO:0022417)2.93391049
128regulation of amyloid precursor protein catabolic process (GO:1902991)2.93024544
129phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.92252304
130action potential (GO:0001508)2.91486602
131axon extension (GO:0048675)2.90431822
132synaptic vesicle exocytosis (GO:0016079)2.87802690
133* positive regulation of adenylate cyclase activity (GO:0045762)2.86088707
134calcium-mediated signaling using intracellular calcium source (GO:0035584)2.84472448
135positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.83648699
136activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.83585491
137otic vesicle formation (GO:0030916)2.83407676
138cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.83009385
139regulation of NFAT protein import into nucleus (GO:0051532)2.82402093
140dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.81306804
141thyroid hormone generation (GO:0006590)2.80679144
142regulation of steroid hormone secretion (GO:2000831)2.80345869
143positive regulation of autophagy (GO:0010508)2.80145910
144regulation of sodium ion transmembrane transporter activity (GO:2000649)2.79836727
145regulation of protein autophosphorylation (GO:0031952)2.79770475
146cellular response to alkaloid (GO:0071312)2.79511039
147eyelid development in camera-type eye (GO:0061029)2.78436209
148epithelial structure maintenance (GO:0010669)2.78218502
149calcium ion-dependent exocytosis (GO:0017156)2.78059995
150negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.77883629
151negative regulation of stem cell differentiation (GO:2000737)2.76103997
152establishment of tissue polarity (GO:0007164)2.75519465
153establishment of planar polarity (GO:0001736)2.75519465
154microtubule polymerization or depolymerization (GO:0031109)2.75403291
155detection of mechanical stimulus (GO:0050982)2.74975908
156regulation of anoikis (GO:2000209)2.74898993
157establishment of monopolar cell polarity (GO:0061162)2.73333470
158establishment or maintenance of monopolar cell polarity (GO:0061339)2.73333470
159sodium ion transmembrane transport (GO:0035725)2.72293499
160negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.72279880
161ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.69886940
162reverse cholesterol transport (GO:0043691)2.69853503
163regulation of cholesterol esterification (GO:0010872)2.69291998
164positive regulation of small GTPase mediated signal transduction (GO:0051057)2.68862078
165endoplasmic reticulum unfolded protein response (GO:0030968)2.68334686
166circadian regulation of gene expression (GO:0032922)2.67329489
167regulation of collateral sprouting (GO:0048670)2.67234213
168positive regulation of nuclease activity (GO:0032075)2.66808817
169ER-nucleus signaling pathway (GO:0006984)2.66770533
170organelle transport along microtubule (GO:0072384)2.66689896
171regulation of nuclease activity (GO:0032069)2.66241244
172positive regulation of cAMP-mediated signaling (GO:0043950)2.65159909
173negative regulation of heart contraction (GO:0045822)2.64495034
174cellular response to unfolded protein (GO:0034620)2.64490679
175multicellular organismal water homeostasis (GO:0050891)2.61742437
176keratan sulfate catabolic process (GO:0042340)2.61529911
177fibrinolysis (GO:0042730)2.61385787
178COPII vesicle coating (GO:0048208)2.60946869
179peptidyl-proline hydroxylation (GO:0019511)2.60601297
180axon cargo transport (GO:0008088)2.60123111
181peristalsis (GO:0030432)2.59298906
182antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.58447612
183regulation of synaptic vesicle transport (GO:1902803)2.58311807
184glomerular filtration (GO:0003094)2.58237795
185neuron projection extension (GO:1990138)2.57504563
186positive regulation of potassium ion transmembrane transport (GO:1901381)2.54943485
187intermediate filament organization (GO:0045109)2.54607846
188histamine secretion (GO:0001821)2.53844131
189positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.53532922
190serotonin metabolic process (GO:0042428)12.5953327
191* detection of temperature stimulus involved in sensory perception of pain (GO:0050965)11.5628114
192* detection of temperature stimulus involved in sensory perception (GO:0050961)11.5628114
193* detection of temperature stimulus (GO:0016048)10.5729235
194primary amino compound metabolic process (GO:1901160)10.3949003
195indolalkylamine metabolic process (GO:0006586)10.0050039

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human4.46023306
2EZH2_22144423_ChIP-Seq_EOC_Human3.19000409
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.94131933
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.85537759
5ESR1_21235772_ChIP-Seq_MCF-7_Human2.67579088
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.65810936
7* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.58940974
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54895820
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.54003741
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53291260
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.52759879
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.48496216
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.47541089
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.39153475
15REST_21632747_ChIP-Seq_MESCs_Mouse2.35193989
16CDX2_20551321_ChIP-Seq_CACO-2_Human2.33421230
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.30536068
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.29325969
19VDR_22108803_ChIP-Seq_LS180_Human2.28881810
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.22496677
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.22496677
22NR3C1_23031785_ChIP-Seq_PC12_Mouse2.19496125
23FOXO3_23340844_ChIP-Seq_DLD1_Human2.12229535
24* NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.10981844
25TCF4_18268006_ChIP-ChIP_LS174T_Human2.09628080
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.07119571
27* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.05276940
28* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.04977042
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.04545724
30ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.00738650
31SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.96957831
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.90601158
33FOXM1_26456572_ChIP-Seq_MCF-7_Human1.85930082
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.84772425
35CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.83652846
36ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.82727988
37EGR1_19032775_ChIP-ChIP_M12_Human1.78581599
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.78332520
39ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.76746510
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.75698758
41TBL1_22424771_ChIP-Seq_293T_Human1.74038046
42FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.73787437
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.73280308
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71513015
45HNFA_21074721_ChIP-Seq_CACO-2_Human1.71050392
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.70714569
47TAF15_26573619_Chip-Seq_HEK293_Human1.70226092
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.69609940
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.68190647
50* EED_16625203_ChIP-ChIP_MESCs_Mouse1.67399072
51NFYB_21822215_ChIP-Seq_K562_Human1.66621923
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.66307445
53NFYA_21822215_ChIP-Seq_K562_Human1.62914318
54PHF8_20622853_ChIP-Seq_HELA_Human1.62908454
55PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.62832105
56ETV1_20927104_ChIP-Seq_GIST48_Human1.62383426
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.59494060
58LXR_22158963_ChIP-Seq_LIVER_Mouse1.57925470
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56143250
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54970479
61* CTCF_27219007_Chip-Seq_Bcells_Human1.54200387
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53318662
63CBX2_22325352_ChIP-Seq_293T-Rex_Human1.53051246
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.52889391
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52622468
66FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.51774010
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51754102
68* CJUN_26792858_Chip-Seq_BT549_Human1.50867101
69EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49611649
70GATA1_22025678_ChIP-Seq_K562_Human1.49155510
71WT1_19549856_ChIP-ChIP_CCG9911_Human1.47867375
72GATA6_21074721_ChIP-Seq_CACO-2_Human1.47865458
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.47843517
74SMAD4_21799915_ChIP-Seq_A2780_Human1.46949988
75SALL4_18804426_ChIP-ChIP_XEN_Mouse1.45422126
76RBPJ_21746931_ChIP-Seq_IB4_Human1.45218892
77GBX2_23144817_ChIP-Seq_PC3_Human1.44972676
78FOXA1_25552417_ChIP-Seq_VCAP_Human1.44520881
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41986984
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41370917
81AHR_22903824_ChIP-Seq_MCF-7_Human1.40875178
82AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.40387145
83RARB_27405468_Chip-Seq_BRAIN_Mouse1.40289689
84MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40173628
85* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40126874
86GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.39023782
87IGF1R_20145208_ChIP-Seq_DFB_Human1.37084185
88SMAD3_21741376_ChIP-Seq_HESCs_Human1.35584851
89KDM2B_26808549_Chip-Seq_K562_Human1.35583560
90SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33506674
91POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32325366
92BCAT_22108803_ChIP-Seq_LS180_Human1.31356010
93DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30988626
94TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.29881637
95SOX2_27498859_Chip-Seq_STOMACH_Mouse1.29754882
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29215863
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29106484
98IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.28617834
99NFIB_24661679_ChIP-Seq_LUNG_Mouse1.28388282
100RXR_22108803_ChIP-Seq_LS180_Human1.27944860
101E2F1_18555785_Chip-Seq_ESCs_Mouse1.27492153
102AR_21572438_ChIP-Seq_LNCaP_Human1.27385785
103FUS_26573619_Chip-Seq_HEK293_Human1.27348654
104CDX2_22108803_ChIP-Seq_LS180_Human1.27273029
105ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27036596
106CMYC_18555785_Chip-Seq_ESCs_Mouse1.26655164
107TP53_18474530_ChIP-ChIP_U2OS_Human1.25030702
108PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.24893209
109* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.22824548
110RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22597652
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22470733
112P53_22387025_ChIP-Seq_ESCs_Mouse1.20712483
113RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.19372166
114SMAD3_21741376_ChIP-Seq_EPCs_Human1.19081629
115CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18501060
116CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17423922
117P300_19829295_ChIP-Seq_ESCs_Human1.17267924
118PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15841803
119NANOG_19829295_ChIP-Seq_ESCs_Human1.15840665
120SOX2_19829295_ChIP-Seq_ESCs_Human1.15840665
121NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15517186
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15517186
123OCT4_18555785_Chip-Seq_ESCs_Mouse1.15154639
124FLI1_27457419_Chip-Seq_LIVER_Mouse1.14710137
125EZH2_27294783_Chip-Seq_NPCs_Mouse1.14188861
126STAT3_18555785_Chip-Seq_ESCs_Mouse1.13735341
127EP300_21415370_ChIP-Seq_HL-1_Mouse1.13304420
128SOX2_21211035_ChIP-Seq_LN229_Gbm1.12657691
129MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12406478
130ZNF274_21170338_ChIP-Seq_K562_Hela1.12228772
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12080277
132KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.11929275
133KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.11929275
134KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.11929275
135FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.11883822
136SOX2_18555785_Chip-Seq_ESCs_Mouse1.11745426
137GATA4_25053715_ChIP-Seq_YYC3_Human1.11697325
138GATA6_25053715_ChIP-Seq_YYC3_Human1.11670841
139P300_18555785_Chip-Seq_ESCs_Mouse1.11447492
140ARNT_22903824_ChIP-Seq_MCF-7_Human1.11221430
141PIAS1_25552417_ChIP-Seq_VCAP_Human1.11208986
142TET1_21490601_ChIP-Seq_MESCs_Mouse1.10434213
143FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.09304951
144PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08699540
145CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.08665150
146POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08303061
147SMAD4_21741376_ChIP-Seq_HESCs_Human1.07715627
148KDM2B_26808549_Chip-Seq_REH_Human1.07697022
149FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.07508950
150TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07453765
151HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07231163
152EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06892478
153STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06674848
154SMAD3_21741376_ChIP-Seq_ESCs_Human1.06564884
155CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06180579
156ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05604380
157KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.04895978
158CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04487013
159P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03876913
160TCF4_22108803_ChIP-Seq_LS180_Human1.03790458
161GATA3_24758297_ChIP-Seq_MCF-7_Human1.03340802
162GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02704253
163TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02686396
164ZNF263_19887448_ChIP-Seq_K562_Human1.02547860
165OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02258860
166SOX2_20726797_ChIP-Seq_SW620_Human1.00700344
167NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99350595
168JUN_21703547_ChIP-Seq_K562_Human0.98596013
169RING1B_27294783_Chip-Seq_ESCs_Mouse0.97240783
170KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96628289
171BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95982489
172ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95478572
173* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.95432569
174ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94125264
175TP53_20018659_ChIP-ChIP_R1E_Mouse0.93892118
176AR_25329375_ChIP-Seq_VCAP_Human0.93645678
177SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93544125
178PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.91584808
179PRDM14_20953172_ChIP-Seq_ESCs_Human0.91099277
180CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90918063
181YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90868004

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0002735_abnormal_chemical_nociception7.16550833
2MP0004270_analgesia6.73240519
3MP0001986_abnormal_taste_sensitivity5.39664077
4* MP0006276_abnormal_autonomic_nervous5.33839922
5MP0001968_abnormal_touch/_nociception5.14957418
6MP0004782_abnormal_surfactant_physiolog4.55223008
7MP0004264_abnormal_extraembryonic_tissu4.46426509
8MP0002736_abnormal_nociception_after4.24432960
9MP0000372_irregular_coat_pigmentation4.23056370
10MP0004858_abnormal_nervous_system4.13511481
11MP0002734_abnormal_mechanical_nocicepti4.06967927
12MP0002733_abnormal_thermal_nociception4.00461153
13MP0005670_abnormal_white_adipose3.83287310
14MP0002638_abnormal_pupillary_reflex3.74803607
15* MP0001970_abnormal_pain_threshold3.35424450
16MP0003303_peritoneal_inflammation3.31600329
17MP0005503_abnormal_tendon_morphology3.14632887
18MP0002751_abnormal_autonomic_nervous3.10564105
19MP0010386_abnormal_urinary_bladder2.80168762
20MP0003195_calcinosis2.15331640
21MP0002168_other_aberrant_phenotype2.13047690
22MP0001666_abnormal_nutrient_absorption2.06963462
23MP0004859_abnormal_synaptic_plasticity1.89669418
24* MP0002184_abnormal_innervation1.89600161
25MP0001348_abnormal_lacrimal_gland1.86486559
26MP0002272_abnormal_nervous_system1.84052955
27MP0002067_abnormal_sensory_capabilities1.77911209
28MP0005365_abnormal_bile_salt1.67319148
29MP0009046_muscle_twitch1.65500743
30MP0004147_increased_porphyrin_level1.60224593
31MP0003566_abnormal_cell_adhesion1.59289271
32MP0002295_abnormal_pulmonary_circulatio1.56821650
33MP0003635_abnormal_synaptic_transmissio1.54000990
34MP0001177_atelectasis1.50049619
35MP0005395_other_phenotype1.49183439
36MP0002063_abnormal_learning/memory/cond1.46845305
37MP0003191_abnormal_cellular_cholesterol1.40753924
38MP0001346_abnormal_lacrimal_gland1.39795334
39MP0003329_amyloid_beta_deposits1.39370310
40MP0002572_abnormal_emotion/affect_behav1.35557401
41MP0009379_abnormal_foot_pigmentation1.35553442
42* MP0009745_abnormal_behavioral_response1.33351947
43MP0002108_abnormal_muscle_morphology1.33177002
44MP0004811_abnormal_neuron_physiology1.32222614
45MP0003136_yellow_coat_color1.29801393
46MP0008775_abnormal_heart_ventricle1.28692904
47MP0000013_abnormal_adipose_tissue1.28185977
48MP0008961_abnormal_basal_metabolism1.28116717
49MP0010678_abnormal_skin_adnexa1.26957649
50MP0001188_hyperpigmentation1.26325672
51MP0000955_abnormal_spinal_cord1.24881961
52MP0002876_abnormal_thyroid_physiology1.24559955
53MP0002233_abnormal_nose_morphology1.24450105
54MP0001440_abnormal_grooming_behavior1.21176332
55MP0000383_abnormal_hair_follicle1.15262010
56MP0010352_gastrointestinal_tract_polyps1.13347946
57MP0002064_seizures1.12814054
58MP0010329_abnormal_lipoprotein_level1.11023783
59MP0005499_abnormal_olfactory_system1.07442385
60MP0005394_taste/olfaction_phenotype1.07442385
61MP0000579_abnormal_nail_morphology1.06710408
62MP0003045_fibrosis1.06026890
63MP0004145_abnormal_muscle_electrophysio1.05512202
64MP0001501_abnormal_sleep_pattern1.05509573
65MP0002909_abnormal_adrenal_gland1.04820161
66MP0001756_abnormal_urination1.04263013
67MP0003937_abnormal_limbs/digits/tail_de1.00969355
68MP0005275_abnormal_skin_tensile0.99681055
69* MP0002882_abnormal_neuron_morphology0.99103738
70MP0001879_abnormal_lymphatic_vessel0.98817476
71MP0004233_abnormal_muscle_weight0.98720909
72MP0008057_abnormal_DNA_replication0.98493722
73MP0004272_abnormal_basement_membrane0.98200553
74MP0002693_abnormal_pancreas_physiology0.97401269
75MP0000613_abnormal_salivary_gland0.94388747
76MP0003632_abnormal_nervous_system0.93897315
77MP0000003_abnormal_adipose_tissue0.93308156
78MP0000427_abnormal_hair_cycle0.93277915
79MP0003880_abnormal_central_pattern0.93078874
80MP0005083_abnormal_biliary_tract0.92604715
81MP0000566_synostosis0.91744878
82MP0008438_abnormal_cutaneous_collagen0.90979940
83MP0003115_abnormal_respiratory_system0.90643636
84MP0005084_abnormal_gallbladder_morpholo0.90473975
85MP0002877_abnormal_melanocyte_morpholog0.89312886
86MP0004142_abnormal_muscle_tone0.88914724
87MP0009840_abnormal_foam_cell0.86927585
88MP0001270_distended_abdomen0.86911096
89MP0008569_lethality_at_weaning0.86365573
90MP0000751_myopathy0.85600407
91MP0003890_abnormal_embryonic-extraembry0.85499350
92MP0003879_abnormal_hair_cell0.85231269
93MP0003279_aneurysm0.84874645
94MP0000534_abnormal_ureter_morphology0.84344897
95MP0008874_decreased_physiological_sensi0.84330108
96MP0005645_abnormal_hypothalamus_physiol0.84201984
97MP0000627_abnormal_mammary_gland0.83332659
98MP0003091_abnormal_cell_migration0.82954704
99MP0001299_abnormal_eye_distance/0.81791996
100MP0002066_abnormal_motor_capabilities/c0.81230521
101MP0005666_abnormal_adipose_tissue0.81204120
102MP0005408_hypopigmentation0.80709412
103MP0004883_abnormal_blood_vessel0.79956840
104MP0003656_abnormal_erythrocyte_physiolo0.79900671
105MP0002282_abnormal_trachea_morphology0.79777076
106MP0003183_abnormal_peptide_metabolism0.79728220
107MP0004924_abnormal_behavior0.78694278
108MP0005386_behavior/neurological_phenoty0.78694278
109MP0002138_abnormal_hepatobiliary_system0.78566182
110MP0002837_dystrophic_cardiac_calcinosis0.77574496
111MP0004484_altered_response_of0.76882939
112MP0000049_abnormal_middle_ear0.76194004
113MP0004036_abnormal_muscle_relaxation0.76051140
114MP0000778_abnormal_nervous_system0.75527064
115MP0003448_altered_tumor_morphology0.74225800
116MP0003724_increased_susceptibility_to0.74071957
117MP0000749_muscle_degeneration0.73849819
118MP0000604_amyloidosis0.73724791
119MP0005164_abnormal_response_to0.73487508
120MP0005375_adipose_tissue_phenotype0.73302281
121MP0000516_abnormal_urinary_system0.73226156
122MP0005367_renal/urinary_system_phenotyp0.73226156
123MP0005220_abnormal_exocrine_pancreas0.72927547
124* MP0002752_abnormal_somatic_nervous0.72836419
125MP0000681_abnormal_thyroid_gland0.71863317
126MP0002229_neurodegeneration0.71778974
127MP0001485_abnormal_pinna_reflex0.70589183
128MP0002557_abnormal_social/conspecific_i0.69241602
129MP0003868_abnormal_feces_composition0.69095047
130MP0002925_abnormal_cardiovascular_devel0.69049773
131MP0003943_abnormal_hepatobiliary_system0.68805240
132MP0004510_myositis0.68431241
133MP0003953_abnormal_hormone_level0.68203467
134MP0001944_abnormal_pancreas_morphology0.67774012
135MP0008872_abnormal_physiological_respon0.66935361
136MP0005535_abnormal_body_temperature0.66877544
137MP0003633_abnormal_nervous_system0.66857271
138MP0000639_abnormal_adrenal_gland0.66160650
139MP0001984_abnormal_olfaction0.65704516
140* MP0001943_abnormal_respiration0.64919766
141MP0002078_abnormal_glucose_homeostasis0.64487965
142MP0005388_respiratory_system_phenotype0.63290130
143MP0002133_abnormal_respiratory_system0.63290130
144MP0003634_abnormal_glial_cell0.62289821
145MP0009780_abnormal_chondrocyte_physiolo0.61938158
146MP0006138_congestive_heart_failure0.61419557
147MP0003646_muscle_fatigue0.60590424
148MP0003690_abnormal_glial_cell0.60515553
149MP0002139_abnormal_hepatobiliary_system0.60491328
150MP0002972_abnormal_cardiac_muscle0.60198293
151MP0003755_abnormal_palate_morphology0.58799511
152MP0010771_integument_phenotype0.56852160
153MP0001486_abnormal_startle_reflex0.56040035
154MP0000538_abnormal_urinary_bladder0.55635842
155MP0005423_abnormal_somatic_nervous0.54653834
156MP0003806_abnormal_nucleotide_metabolis0.54299934
157MP0004742_abnormal_vestibular_system0.53767492
158MP0000759_abnormal_skeletal_muscle0.52469088
159MP0005410_abnormal_fertilization0.51832095
160MP0000747_muscle_weakness0.51243618
161MP0000920_abnormal_myelination0.50667637
162MP0003631_nervous_system_phenotype0.47065471
163MP0004084_abnormal_cardiac_muscle0.46548441
164* MP0004085_abnormal_heartbeat0.45240256
165MP0005165_increased_susceptibility_to0.45046107
166* MP0001963_abnormal_hearing_physiology0.43564414
167MP0001905_abnormal_dopamine_level0.42871849
168MP0005620_abnormal_muscle_contractility0.42723082
169MP0002160_abnormal_reproductive_system0.41286342
170MP0005448_abnormal_energy_balance0.40720242
171MP0002069_abnormal_eating/drinking_beha0.39662279
172MP0005197_abnormal_uvea_morphology0.37827233
173MP0001502_abnormal_circadian_rhythm0.35774251
174MP0004134_abnormal_chest_morphology0.34904971
175MP0002269_muscular_atrophy0.32188984
176MP0009764_decreased_sensitivity_to0.31956588
177MP0008789_abnormal_olfactory_epithelium0.31537475

Predicted human phenotypes

RankGene SetZ-score
1Autoamputation (HP:0001218)7.87724669
2Dysautonomia (HP:0002459)7.34314730
3Arthropathy (HP:0003040)7.10018415
4Impaired pain sensation (HP:0007328)6.42771464
5Abnormality of pain sensation (HP:0010832)6.42771464
6Ulnar claw (HP:0001178)5.97162608
7Dysmetric saccades (HP:0000641)5.84084534
8Action tremor (HP:0002345)5.69561765
9Limb hypertonia (HP:0002509)5.44231104
10Recurrent corneal erosions (HP:0000495)5.36497497
11Myokymia (HP:0002411)5.26811199
12Orthostatic hypotension (HP:0001278)5.08023306
13Postural tremor (HP:0002174)5.03164179
14Interstitial pulmonary disease (HP:0006530)4.89061033
15Thyroid carcinoma (HP:0002890)4.84851560
16Deep venous thrombosis (HP:0002625)4.72858641
17Hypothermia (HP:0002045)4.51796344
18Decreased number of peripheral myelinated nerve fibers (HP:0003380)4.51740542
19Anhidrosis (HP:0000970)4.35268337
20Prolonged partial thromboplastin time (HP:0003645)4.33370349
21Gastrointestinal infarctions (HP:0005244)4.21768883
22Episodic fever (HP:0001954)4.20818068
23Abnormality of dental color (HP:0011073)4.16034666
24Abnormal autonomic nervous system physiology (HP:0012332)4.12394808
25Peritonitis (HP:0002586)3.98288628
26Termporal pattern (HP:0011008)3.93974463
27Insidious onset (HP:0003587)3.93974463
28Hyperactive renin-angiotensin system (HP:0000841)3.88575723
29Self-mutilation (HP:0000742)3.78106653
30Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.73624785
31Vertebral hypoplasia (HP:0008417)3.73624785
32Central scotoma (HP:0000603)3.73105572
33Vascular calcification (HP:0004934)3.66756371
34Pheochromocytoma (HP:0002666)3.66493426
35Chronic bronchitis (HP:0004469)3.65863430
36Abnormality of calcium-phosphate metabolism (HP:0100530)3.53742624
37Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.47491908
38Neuroendocrine neoplasm (HP:0100634)3.47045459
39Sensory axonal neuropathy (HP:0003390)3.43337364
40Follicular hyperkeratosis (HP:0007502)3.30965579
41Cardiovascular calcification (HP:0011915)3.22149454
42Alopecia of scalp (HP:0002293)3.20761900
43Foot dorsiflexor weakness (HP:0009027)3.20160868
44Hyporeflexia of lower limbs (HP:0002600)3.15675534
45Limb dystonia (HP:0002451)3.12212630
46Curly hair (HP:0002212)3.11359496
47Abnormality of the common coagulation pathway (HP:0010990)3.09800707
48Myotonia (HP:0002486)3.07444056
49Bronchomalacia (HP:0002780)3.00777239
50Systemic lupus erythematosus (HP:0002725)3.00739284
51Macroorchidism (HP:0000053)3.00391213
52Hyperaldosteronism (HP:0000859)2.99140745
53Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.98281629
54Distal lower limb muscle weakness (HP:0009053)2.92219036
55Hypotrichosis (HP:0001006)2.91412301
56Atonic seizures (HP:0010819)2.90002372
57Areflexia of lower limbs (HP:0002522)2.83937632
58Abnormality of the corticospinal tract (HP:0002492)2.83083651
59Abnormality of the foot musculature (HP:0001436)2.82002685
60Hyperphosphatemia (HP:0002905)2.80735805
61Segmental peripheral demyelination/remyelination (HP:0003481)2.79802106
62Renal salt wasting (HP:0000127)2.79496088
63Papilledema (HP:0001085)2.78458819
64Hypercortisolism (HP:0001578)2.75590611
65Bradycardia (HP:0001662)2.74223280
66Delusions (HP:0000746)2.69290673
67Cone-rod dystrophy (HP:0000548)2.67494382
68Steppage gait (HP:0003376)2.65046183
69Abnormality of proline metabolism (HP:0010907)2.63109601
70Hydroxyprolinuria (HP:0003080)2.63109601
71Abnormal pupillary function (HP:0007686)2.62405166
72Osteomalacia (HP:0002749)2.61265416
73Double outlet right ventricle (HP:0001719)2.61260072
74Congenital malformation of the right heart (HP:0011723)2.61260072
75Ankle clonus (HP:0011448)2.60551518
76Focal seizures (HP:0007359)2.59356236
77Abnormality of the aortic arch (HP:0012303)2.53488124
78Neoplasm of the peripheral nervous system (HP:0100007)2.53231544
79Hammertoe (HP:0001765)2.52843958
80Neoplasm of the thyroid gland (HP:0100031)2.52337242
81Hypoventilation (HP:0002791)2.52335127
82Hypochromic microcytic anemia (HP:0004840)2.51458199
83Distal sensory impairment (HP:0002936)2.50856597
84Genetic anticipation (HP:0003743)2.50390195
85Urinary urgency (HP:0000012)2.49297965
86Febrile seizures (HP:0002373)2.48087291
8711 pairs of ribs (HP:0000878)2.47814250
88Mild short stature (HP:0003502)2.46145112
89Papillary thyroid carcinoma (HP:0002895)2.45201708
90Lack of skin elasticity (HP:0100679)2.44409100
91Complement deficiency (HP:0004431)2.44194470
92Supranuclear gaze palsy (HP:0000605)2.41531019
93Abnormality of aromatic amino acid family metabolism (HP:0004338)2.41413916
94Bronchitis (HP:0012387)2.39002752
95Prostate neoplasm (HP:0100787)2.38588032
96Toxemia of pregnancy (HP:0100603)2.36710212
97Abnormal sex determination (HP:0012244)2.35418721
98Sex reversal (HP:0012245)2.35418721
99Hypotension (HP:0002615)2.32414012
100Abnormality of chloride homeostasis (HP:0011422)2.30244438
101Abnormality of permanent molar morphology (HP:0011071)2.28810778
102Abnormality of the dental root (HP:0006486)2.28810778
103Taurodontia (HP:0000679)2.28810778
104Failure to thrive in infancy (HP:0001531)2.27609415
105Muscle fibrillation (HP:0010546)2.26126680
106Nail dystrophy (HP:0008404)2.24439743
107Abnormality of liposaccharide metabolism (HP:0010968)2.23903863
108Abnormality of glycosphingolipid metabolism (HP:0004343)2.23903863
109Abnormality of glycolipid metabolism (HP:0010969)2.23903863
110Respiratory distress (HP:0002098)2.23101741
111Spastic gait (HP:0002064)2.22776290
112Metaphyseal dysplasia (HP:0100255)2.22058135
113Congenital sensorineural hearing impairment (HP:0008527)2.19765229
114Adrenal overactivity (HP:0002717)2.19427173
115Abnormality of the dental pulp (HP:0006479)2.16708343
116Acute hepatic failure (HP:0006554)2.15491457
117Keratitis (HP:0000491)2.14259399
118Abnormality of molar (HP:0011077)2.13316086
119Abnormality of molar morphology (HP:0011070)2.13316086
120Abnormality of the vocal cords (HP:0008777)2.12564088
121Hyperkalemia (HP:0002153)2.12080352
122Goiter (HP:0000853)2.11188054
123Ventricular fibrillation (HP:0001663)2.10867315
124Missing ribs (HP:0000921)2.10562382
125Thickened calvaria (HP:0002684)2.10313968
126Apathy (HP:0000741)2.09971338
127Scotoma (HP:0000575)2.09879983
128Fasciculations (HP:0002380)2.09177354
129Pigmentary retinal degeneration (HP:0001146)2.09155772
130Decreased motor nerve conduction velocity (HP:0003431)2.08964380
131Emotional lability (HP:0000712)2.06152126
132Osteomyelitis (HP:0002754)2.05955816
133Progressive cerebellar ataxia (HP:0002073)2.05923208
134Degeneration of the lateral corticospinal tracts (HP:0002314)2.04419971
135Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.04419971
136Mitral stenosis (HP:0001718)2.03576091
137Abnormal hair whorl (HP:0010721)2.02056845
138Dysostosis multiplex (HP:0000943)2.01920968
139Palpitations (HP:0001962)2.01386172
140Poor suck (HP:0002033)2.00583866
141Urinary glycosaminoglycan excretion (HP:0003541)1.98443763
142Mucopolysacchariduria (HP:0008155)1.98443763
143Torticollis (HP:0000473)1.97494318
144Abnormality of macular pigmentation (HP:0008002)1.97205847
145Stridor (HP:0010307)1.96479799
146Onion bulb formation (HP:0003383)1.95852587
147Abnormality of mucopolysaccharide metabolism (HP:0011020)1.95723657
148Abnormality of polysaccharide metabolism (HP:0011012)1.95723657
149Abnormality of glycosaminoglycan metabolism (HP:0004371)1.95723657
150Tongue fasciculations (HP:0001308)1.95165291
151Scanning speech (HP:0002168)1.94736928
152Abnormal pancreas size (HP:0012094)1.94333945
153Menorrhagia (HP:0000132)1.93441334
154Absence seizures (HP:0002121)1.93114461
155Focal motor seizures (HP:0011153)1.89381428
156Depression (HP:0000716)1.89210821
157Alveolar cell carcinoma (HP:0006519)1.88927071
158Diminished motivation (HP:0000745)1.88770596
159Skin nodule (HP:0200036)1.88687384
160Facial shape deformation (HP:0011334)1.87831877
161Potter facies (HP:0002009)1.87831877
162Oligomenorrhea (HP:0000876)1.86977908
163Stenosis of the external auditory canal (HP:0000402)1.86426142
164Lower limb hyperreflexia (HP:0002395)1.86274262
165Rapidly progressive (HP:0003678)1.86085030
166Urinary bladder sphincter dysfunction (HP:0002839)1.85192145
167Annular pancreas (HP:0001734)1.84622219
168Hypokalemic alkalosis (HP:0001949)1.84498799
169Glomerulonephritis (HP:0000099)1.83845588
170Anxiety (HP:0000739)1.83533875
171Sudden death (HP:0001699)1.82592566
172Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.81925196
173Amblyopia (HP:0000646)1.81811176
174Lower limb muscle weakness (HP:0007340)1.81790753
175Abnormality of renin-angiotensin system (HP:0000847)1.81513599
176Abnormality of magnesium homeostasis (HP:0004921)1.78072295
177Menstrual irregularities (HP:0000858)1.77005050
178EMG: neuropathic changes (HP:0003445)1.73171462
179Epileptic encephalopathy (HP:0200134)1.71017799
180Abnormal eating behavior (HP:0100738)1.69240732
181Dialeptic seizures (HP:0011146)1.67474733
182Irregular epiphyses (HP:0010582)1.67119606
183Growth hormone excess (HP:0000845)1.63983884
184Abnormality of the lower motor neuron (HP:0002366)1.63517690
185Testicular neoplasm (HP:0010788)1.60931674
186Generalized tonic-clonic seizures (HP:0002069)1.60859928
187Aplasia/Hypoplasia of the brainstem (HP:0007362)1.60816671
188Hypoplasia of the brainstem (HP:0002365)1.60816671
189Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.59496853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK19.35908292
2MATK6.71576099
3TAOK34.95789468
4TYK24.43830587
5BRSK23.33969944
6MINK13.03847941
7KSR22.88464974
8TRIM282.72036123
9SCYL22.68236437
10MAP3K22.33339093
11CASK2.28525248
12ADRBK22.15915694
13LIMK12.10656843
14MAPKAPK32.07095990
15LMTK22.06732383
16MAP3K122.04697885
17EPHA22.02057497
18STK38L1.92387940
19NTRK31.87279891
20MKNK21.82256012
21MAP3K31.77824786
22GRK11.77327654
23RIPK41.75061971
24DYRK31.61609131
25PIK3CA1.58781068
26BRSK11.58005226
27ERBB41.55054879
28FGFR21.54992861
29NLK1.51041063
30ERN11.50681094
31MAP2K11.49195242
32FER1.49132089
33GRK51.46094274
34ARAF1.43467755
35MAP3K91.41364020
36EPHA31.37998164
37ERBB21.37977897
38RET1.36014088
39STK391.34331156
40SIK31.33423881
41DYRK1A1.23027798
42SGK21.14819125
43TNIK1.14733722
44MAPK131.13287378
45SGK4941.10445672
46SGK2231.10445672
47LATS21.07646148
48TEC1.03140756
49BMPR21.01116297
50OXSR10.98960124
51JAK10.97549351
52IRAK10.96525241
53ACVR1B0.95951131
54RPS6KA20.90924451
55STK240.90809807
56MAP2K40.89186646
57PRKCI0.87800186
58INSRR0.87779427
59MAP3K10.87229780
60RIPK10.86189273
61MST40.86111192
62PHKG20.85981680
63PHKG10.85981680
64STK380.85563853
65ADRBK10.85270506
66ALK0.85111645
67MAP2K20.84983648
68YES10.83567242
69SGK30.82729782
70STK30.80714610
71BCR0.76713574
72MKNK10.76543084
73TIE10.76025334
74KIT0.75735912
75TAOK10.73361120
76PRKCG0.72414095
77MAP2K60.71411688
78MARK10.70726479
79TESK10.70500552
80FGFR10.70362397
81PRKCE0.69403207
82DAPK20.68583654
83PAK30.67600074
84MAP3K40.64671734
85MAP3K140.63679885
86EIF2AK30.59167562
87NEK10.58760353
88WEE10.58680826
89UHMK10.56620611
90PRKAA20.56470903
91DYRK20.55626221
92LRRK20.55196702
93PDGFRA0.53300094
94KSR10.53211976
95CDK50.52986824
96PRPF4B0.52946664
97ROCK20.52921523
98CSNK1A10.52211046
99PDK30.50279313
100PDK40.50279313
101PRKCH0.50202722
102EPHB10.48706280
103STK100.48074199
104BRAF0.47971288
105MST1R0.47294204
106CDK140.46504064
107PRKG20.45255728
108EGFR0.45069367
109NEK60.44933223
110WNK40.44900893
111PAK60.44621498
112AKT30.44579655
113EPHB20.43663094
114MAP2K70.42718919
115SRC0.42047101
116FGFR40.41817503
117PINK10.41379604
118ITK0.40704532
119MYLK0.40416471
120CSNK1E0.40153545
121AURKA0.39559072
122MAP3K110.37795413
123IKBKE0.37114341
124IRAK40.36044214
125DAPK10.35769325
126CAMKK20.33889928
127CAMK2G0.33247812
128AKT20.32807928
129DMPK0.32115341
130CDK60.32027531
131FGFR30.30431540
132WNK10.30180120
133CAMKK10.30056249
134PDPK10.29149180
135RPS6KA30.28902702
136PDK10.28810601
137TNK20.27918875
138EIF2AK10.26895464
139BMPR1B0.26521531
140PDGFRB0.26469700
141MARK30.26089079
142IRAK20.25996254
143CAMK2A0.25532307
144CDK180.25132848
145PAK20.24947692
146RPS6KB20.24415194
147INSR0.24375773
148CSNK2A20.23316458
149PRKACA0.23262977
150CSNK2A10.23007656
151JAK20.22491894
152PTK2B0.22226962
153IGF1R0.21977640
154CSNK1G20.21875833
155PLK20.21510885
156ROCK10.20854799
157PTK20.20558156
158NEK90.19630827
159PRKCD0.19364969
160CDC42BPA0.17719882
161RPS6KC10.17469930
162RPS6KL10.17469930
163PRKACG0.16177248
164CSNK1G30.15404299

Predicted pathways (KEGG)

RankGene SetZ-score
1Tryptophan metabolism_Homo sapiens_hsa003806.05688221
2Protein export_Homo sapiens_hsa030604.53594736
3Phenylalanine metabolism_Homo sapiens_hsa003603.99507216
4Thyroid cancer_Homo sapiens_hsa052163.81974835
5Synaptic vesicle cycle_Homo sapiens_hsa047213.45808004
6Circadian rhythm_Homo sapiens_hsa047103.43649224
7Vasopressin-regulated water reabsorption_Homo sapiens_hsa049623.33792746
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049613.20995869
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.19890926
10Histidine metabolism_Homo sapiens_hsa003403.11831511
11Complement and coagulation cascades_Homo sapiens_hsa046103.09349693
12Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047502.65325553
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.35047124
14Insulin secretion_Homo sapiens_hsa049112.12401256
15Olfactory transduction_Homo sapiens_hsa047402.07533181
16Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050142.06517065
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.05167722
18Type I diabetes mellitus_Homo sapiens_hsa049402.02400896
19Neurotrophin signaling pathway_Homo sapiens_hsa047222.01496719
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.93638301
21N-Glycan biosynthesis_Homo sapiens_hsa005101.87509939
22Central carbon metabolism in cancer_Homo sapiens_hsa052301.77460733
23Tyrosine metabolism_Homo sapiens_hsa003501.70171290
24Long-term potentiation_Homo sapiens_hsa047201.68135939
25Cholinergic synapse_Homo sapiens_hsa047251.65632227
26Arginine and proline metabolism_Homo sapiens_hsa003301.63345192
27Melanoma_Homo sapiens_hsa052181.60641567
28Cocaine addiction_Homo sapiens_hsa050301.55281791
29Dopaminergic synapse_Homo sapiens_hsa047281.55040595
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.52574776
31Collecting duct acid secretion_Homo sapiens_hsa049661.46409564
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42775822
33Dorso-ventral axis formation_Homo sapiens_hsa043201.39290949
34Gastric acid secretion_Homo sapiens_hsa049711.36518634
35Circadian entrainment_Homo sapiens_hsa047131.31502489
36Glioma_Homo sapiens_hsa052141.29226107
37GnRH signaling pathway_Homo sapiens_hsa049121.28948178
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.28090934
39VEGF signaling pathway_Homo sapiens_hsa043701.27766856
40Sphingolipid metabolism_Homo sapiens_hsa006001.23596179
41Staphylococcus aureus infection_Homo sapiens_hsa051501.22483758
42Thyroid hormone synthesis_Homo sapiens_hsa049181.18885617
43Renin secretion_Homo sapiens_hsa049241.18761556
44Sulfur metabolism_Homo sapiens_hsa009201.17676821
45Phototransduction_Homo sapiens_hsa047441.16136092
46Antigen processing and presentation_Homo sapiens_hsa046121.14000802
47Vibrio cholerae infection_Homo sapiens_hsa051101.13651557
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.11452490
49Endometrial cancer_Homo sapiens_hsa052131.09833093
50Primary bile acid biosynthesis_Homo sapiens_hsa001201.08959331
51Taste transduction_Homo sapiens_hsa047421.06598272
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.05727672
53Phagosome_Homo sapiens_hsa041451.05178088
54Glutamatergic synapse_Homo sapiens_hsa047241.04214560
55Mineral absorption_Homo sapiens_hsa049781.04061008
56Gap junction_Homo sapiens_hsa045401.03756281
57Serotonergic synapse_Homo sapiens_hsa047261.02273298
58Salmonella infection_Homo sapiens_hsa051321.00841661
59Salivary secretion_Homo sapiens_hsa049700.99002029
60Nicotine addiction_Homo sapiens_hsa050330.98191520
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98107628
62ErbB signaling pathway_Homo sapiens_hsa040120.98027705
63ABC transporters_Homo sapiens_hsa020100.97998520
64Insulin signaling pathway_Homo sapiens_hsa049100.97355696
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.95847837
66Long-term depression_Homo sapiens_hsa047300.95187294
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.95125032
68Estrogen signaling pathway_Homo sapiens_hsa049150.94329494
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92708063
70Melanogenesis_Homo sapiens_hsa049160.91464426
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.91357445
72Oocyte meiosis_Homo sapiens_hsa041140.91168581
73Lysosome_Homo sapiens_hsa041420.90922576
74Cardiac muscle contraction_Homo sapiens_hsa042600.90765650
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89401574
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88208744
77Prolactin signaling pathway_Homo sapiens_hsa049170.85589012
78Amphetamine addiction_Homo sapiens_hsa050310.85031293
79MAPK signaling pathway_Homo sapiens_hsa040100.83431702
80Endocytosis_Homo sapiens_hsa041440.83095407
81Oxidative phosphorylation_Homo sapiens_hsa001900.81262738
82Bile secretion_Homo sapiens_hsa049760.79819531
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78838968
84GABAergic synapse_Homo sapiens_hsa047270.77196322
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76834636
86Allograft rejection_Homo sapiens_hsa053300.76785665
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76585049
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74593744
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.74571274
90Other glycan degradation_Homo sapiens_hsa005110.74484516
91Morphine addiction_Homo sapiens_hsa050320.74345034
92Pertussis_Homo sapiens_hsa051330.74306500
93Alzheimers disease_Homo sapiens_hsa050100.73427302
94Axon guidance_Homo sapiens_hsa043600.73076914
95Bladder cancer_Homo sapiens_hsa052190.72776966
96Graft-versus-host disease_Homo sapiens_hsa053320.70545040
97Autoimmune thyroid disease_Homo sapiens_hsa053200.69904222
98Oxytocin signaling pathway_Homo sapiens_hsa049210.69782079
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67493663
100Parkinsons disease_Homo sapiens_hsa050120.66868411
101Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66588398
102Steroid biosynthesis_Homo sapiens_hsa001000.66573471
103Pyruvate metabolism_Homo sapiens_hsa006200.66049080
104Rap1 signaling pathway_Homo sapiens_hsa040150.64825695
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.64246685
106Non-small cell lung cancer_Homo sapiens_hsa052230.62870836
107Calcium signaling pathway_Homo sapiens_hsa040200.60715507
108Ras signaling pathway_Homo sapiens_hsa040140.59854189
109Glucagon signaling pathway_Homo sapiens_hsa049220.59396957
110ECM-receptor interaction_Homo sapiens_hsa045120.58779608
111Choline metabolism in cancer_Homo sapiens_hsa052310.58750083
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57899349
113Prion diseases_Homo sapiens_hsa050200.57866182
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57603015
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57585959
116Adherens junction_Homo sapiens_hsa045200.56995507
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56105701
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55869015
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.55703653
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54942167
121Retinol metabolism_Homo sapiens_hsa008300.53200139
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51324124
123Folate biosynthesis_Homo sapiens_hsa007900.48423588
124cAMP signaling pathway_Homo sapiens_hsa040240.48096164
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46819891
126Viral myocarditis_Homo sapiens_hsa054160.46314085
127Fatty acid elongation_Homo sapiens_hsa000620.46115858
128Type II diabetes mellitus_Homo sapiens_hsa049300.45804591
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44992285
130Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44246017
131Apoptosis_Homo sapiens_hsa042100.43874112
132Huntingtons disease_Homo sapiens_hsa050160.43177916
133Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42758458
134Regulation of autophagy_Homo sapiens_hsa041400.42712430
135Hippo signaling pathway_Homo sapiens_hsa043900.42588180
136Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42399107
137Insulin resistance_Homo sapiens_hsa049310.40449497
138mTOR signaling pathway_Homo sapiens_hsa041500.40395651
139Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39790399
140Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39597937
141Protein digestion and absorption_Homo sapiens_hsa049740.39114001
142Leukocyte transendothelial migration_Homo sapiens_hsa046700.39054575
143Basal cell carcinoma_Homo sapiens_hsa052170.38750213
144Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38685167
145Shigellosis_Homo sapiens_hsa051310.38255103
146Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38090780
147Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37319853
148Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37210171
149Proteasome_Homo sapiens_hsa030500.36939024
150Prostate cancer_Homo sapiens_hsa052150.35355734
151Linoleic acid metabolism_Homo sapiens_hsa005910.34343664
152TGF-beta signaling pathway_Homo sapiens_hsa043500.32448793
153Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28300507
154Steroid hormone biosynthesis_Homo sapiens_hsa001400.27634442
155Notch signaling pathway_Homo sapiens_hsa043300.26589614
156Propanoate metabolism_Homo sapiens_hsa006400.24416958
157Arginine biosynthesis_Homo sapiens_hsa002200.23165893
158Tight junction_Homo sapiens_hsa045300.22823278
159Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22273964
160Selenocompound metabolism_Homo sapiens_hsa004500.21851108
161Cysteine and methionine metabolism_Homo sapiens_hsa002700.21739988
162Renal cell carcinoma_Homo sapiens_hsa052110.17240588
163Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.17093255
164Hepatitis C_Homo sapiens_hsa051600.16981726
165mRNA surveillance pathway_Homo sapiens_hsa030150.15486745
1662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.15460222
167PI3K-Akt signaling pathway_Homo sapiens_hsa041510.13810506
168Ether lipid metabolism_Homo sapiens_hsa005650.13515485
169Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.13455861
170Inositol phosphate metabolism_Homo sapiens_hsa005620.12348341
171Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.11999452

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