CACNG6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Voltage-dependent calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of two known gamma subunit proteins. This particular gamma subunit is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members that function as transmembrane AMPA receptor regulatory proteins (TARPs). Alternative splicing results in multiple transcript variants. Variants in this gene have been associated with aspirin-intolerant asthma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.80956353
2skeletal muscle adaptation (GO:0043501)9.41839120
3skeletal muscle fiber development (GO:0048741)8.34323707
4actin filament-based movement (GO:0030048)7.86368666
5plasma membrane repair (GO:0001778)7.52506528
6axoneme assembly (GO:0035082)7.43571440
7positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)7.27291850
8myotube cell development (GO:0014904)7.13713047
9primary alcohol catabolic process (GO:0034310)7.00913713
10striated muscle contraction (GO:0006941)6.92452999
11sarcomere organization (GO:0045214)6.92061466
12response to stimulus involved in regulation of muscle adaptation (GO:0014874)6.89489197
13left/right pattern formation (GO:0060972)6.66275083
14glycogen catabolic process (GO:0005980)6.25110517
15striated muscle atrophy (GO:0014891)6.20046370
16myofibril assembly (GO:0030239)6.18083266
17regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.98271815
18response to inactivity (GO:0014854)5.97860043
19skeletal muscle tissue regeneration (GO:0043403)5.96900398
20carnitine shuttle (GO:0006853)5.84994357
21glucan catabolic process (GO:0009251)5.83978176
22regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.80622441
23response to muscle activity (GO:0014850)5.76358720
24pyrimidine ribonucleoside catabolic process (GO:0046133)5.73616691
25regulation of cilium movement (GO:0003352)5.70793136
26regulation of cell communication by electrical coupling (GO:0010649)5.68661934
27creatine metabolic process (GO:0006600)5.67834012
28muscle contraction (GO:0006936)5.63130743
29purine nucleotide salvage (GO:0032261)5.56248510
30negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.48832589
31cellular polysaccharide catabolic process (GO:0044247)5.48206110
32ethanol metabolic process (GO:0006067)5.46181320
33striated muscle adaptation (GO:0014888)5.43183952
34cytidine metabolic process (GO:0046087)5.43100027
35cytidine catabolic process (GO:0006216)5.43100027
36cytidine deamination (GO:0009972)5.43100027
37IMP metabolic process (GO:0046040)5.42625403
38vitamin transmembrane transport (GO:0035461)5.40976837
39muscle atrophy (GO:0014889)5.33620417
40polysaccharide catabolic process (GO:0000272)5.18952543
41muscle fiber development (GO:0048747)5.16672733
42regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.10846400
43muscle system process (GO:0003012)5.00249783
44microtubule bundle formation (GO:0001578)4.96424448
45glucan biosynthetic process (GO:0009250)4.92821415
46glycogen biosynthetic process (GO:0005978)4.92821415
47diterpenoid biosynthetic process (GO:0016102)4.87854950
48actomyosin structure organization (GO:0031032)4.86933316
49fatty acid transmembrane transport (GO:1902001)4.84698278
50left/right axis specification (GO:0070986)4.75296409
51regulation of acyl-CoA biosynthetic process (GO:0050812)4.69634888
52negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.66456435
53ventricular system development (GO:0021591)4.52905408
54IMP biosynthetic process (GO:0006188)4.39743103
55pyrimidine-containing compound transmembrane transport (GO:0072531)4.37523340
56muscle adaptation (GO:0043500)4.35594319
57cytoplasmic microtubule organization (GO:0031122)4.35394395
58ethanol oxidation (GO:0006069)4.32776432
59regulation of cofactor metabolic process (GO:0051193)4.32270040
60regulation of coenzyme metabolic process (GO:0051196)4.32270040
61response to xenobiotic stimulus (GO:0009410)4.30541759
62intraciliary transport (GO:0042073)4.29661693
63negative regulation of potassium ion transmembrane transport (GO:1901380)4.28353058
64glycogen metabolic process (GO:0005977)4.26781129
65cardiac muscle contraction (GO:0060048)4.22719788
66lung epithelium development (GO:0060428)4.22666822
67carnitine transmembrane transport (GO:1902603)4.22448308
68one-carbon compound transport (GO:0019755)4.19788352
69muscle cell cellular homeostasis (GO:0046716)4.19174875
70glucan metabolic process (GO:0044042)4.17836122
71cellular glucan metabolic process (GO:0006073)4.17836122
72neuromuscular synaptic transmission (GO:0007274)4.13006606
73regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.09294025
74negative regulation of muscle hypertrophy (GO:0014741)4.07631729
75positive regulation of myoblast differentiation (GO:0045663)4.06860205
76muscle organ development (GO:0007517)4.03692673
77striated muscle cell development (GO:0055002)4.03169580
78myotube differentiation (GO:0014902)4.00926013
79neuronal action potential propagation (GO:0019227)3.99276747
80muscle structure development (GO:0061061)3.96986618
81tricarboxylic acid cycle (GO:0006099)3.95311893
82sperm capacitation (GO:0048240)3.93299772
83negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.93221149
84muscle organ morphogenesis (GO:0048644)3.90199575
85positive regulation of myotube differentiation (GO:0010831)3.89716188
86cilium organization (GO:0044782)3.89221707
87negative regulation of T cell differentiation in thymus (GO:0033085)3.88123130
88establishment of apical/basal cell polarity (GO:0035089)3.85325649
89carnitine transport (GO:0015879)3.83302043
90amino-acid betaine transport (GO:0015838)3.83302043
91tolerance induction (GO:0002507)3.81952255
92response to activity (GO:0014823)3.81567058
93regulation of germinal center formation (GO:0002634)3.78620049
94regulation of skeletal muscle cell differentiation (GO:2001014)3.78229480
95cilium assembly (GO:0042384)3.77657380
96cardiac myofibril assembly (GO:0055003)3.77649791
97regulation of relaxation of muscle (GO:1901077)3.77074847
98skeletal muscle tissue development (GO:0007519)3.72871283
99negative regulation of immunoglobulin mediated immune response (GO:0002890)3.70101004
100negative regulation of B cell mediated immunity (GO:0002713)3.70101004
101positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.70018954
102glomerular epithelial cell development (GO:0072310)3.59681256
103negative regulation of skeletal muscle tissue development (GO:0048642)3.57172616
104regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.56437337
105cellular component assembly involved in morphogenesis (GO:0010927)3.55686619
106heart process (GO:0003015)3.55306742
107heart contraction (GO:0060047)3.55306742
108negative regulation of inclusion body assembly (GO:0090084)3.55008295
109regulation of calcium ion transmembrane transporter activity (GO:1901019)3.52465694
110regulation of calcium ion transmembrane transport (GO:1903169)3.52465694
111myoblast fusion (GO:0007520)3.52180635
112negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.51253511
113retinoic acid metabolic process (GO:0042573)3.50573428
114muscle cell development (GO:0055001)3.45702585
115regulation of sulfur metabolic process (GO:0042762)3.44027053
116regulation of striated muscle contraction (GO:0006942)3.43943395
117regulation of microtubule-based movement (GO:0060632)3.42966421
118cellular carbohydrate catabolic process (GO:0044275)3.42826004
119cellular response to dexamethasone stimulus (GO:0071549)3.39626203
120establishment of monopolar cell polarity (GO:0061162)3.35892591
121establishment or maintenance of monopolar cell polarity (GO:0061339)3.35892591
122cardiac muscle cell development (GO:0055013)3.34738871
123muscle cell fate commitment (GO:0042693)3.30305886
124terpenoid biosynthetic process (GO:0016114)3.28327115
125regulation of actin filament-based movement (GO:1903115)3.27610563
126regulation of interleukin-5 production (GO:0032674)3.25560440
127negative regulation of cAMP-mediated signaling (GO:0043951)3.24783322
128positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.22822965
129neuromuscular junction development (GO:0007528)3.22664105
130syncytium formation (GO:0006949)3.20788759
131microtubule-based movement (GO:0007018)3.20456985
132regulation of myoblast differentiation (GO:0045661)3.19778100
133centriole assembly (GO:0098534)3.17141979
134response to dexamethasone (GO:0071548)3.13928338
135syncytium formation by plasma membrane fusion (GO:0000768)3.09750504
136regulation of microtubule depolymerization (GO:0031114)3.09430588
137positive regulation of tolerance induction (GO:0002645)3.09410297
138negative regulation of humoral immune response (GO:0002921)3.03982225
139protein localization to cilium (GO:0061512)2.92555073
140carnitine metabolic process (GO:0009437)2.92072348
141regulation of response to osmotic stress (GO:0047484)2.85488523
142cell projection assembly (GO:0030031)2.85418614
143regulation of interleukin-13 production (GO:0032656)2.84473096
144negative regulation of microtubule depolymerization (GO:0007026)2.76508269
145nucleoside diphosphate phosphorylation (GO:0006165)2.75512968
146axonemal dynein complex assembly (GO:0070286)16.6759714
147cilium or flagellum-dependent cell motility (GO:0001539)13.0534384
148muscle filament sliding (GO:0030049)12.9284094
149actin-myosin filament sliding (GO:0033275)12.9284094
150regulation of skeletal muscle contraction (GO:0014819)11.7810524
151skeletal muscle contraction (GO:0003009)11.4854567
152motile cilium assembly (GO:0044458)11.3767937
153cilium movement (GO:0003341)11.2453249
154epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.7177790
155actin-mediated cell contraction (GO:0070252)10.5832931
156sarcoplasmic reticulum calcium ion transport (GO:0070296)10.2384993

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.88127436
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.44658911
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.12915865
4ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.83964224
5ESR1_20079471_ChIP-ChIP_T-47D_Human3.70350991
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.47740213
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.34604782
8BCL3_23251550_ChIP-Seq_MUSCLE_Mouse3.10007610
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.07740883
10ZNF263_19887448_ChIP-Seq_K562_Human2.91969676
11TBX20_22328084_ChIP-Seq_HEART_Mouse2.66211373
12TBX20_22080862_ChIP-Seq_HEART_Mouse2.66211373
13MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.42845641
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.41646592
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.34803671
16TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.21300903
17FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.19364097
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.05535577
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.02848152
20SMC4_20622854_ChIP-Seq_HELA_Human1.98028149
21CTCF_21964334_ChIP-Seq_BJAB-B_Human1.97196970
22ZNF274_21170338_ChIP-Seq_K562_Hela1.96423374
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84515303
24RUNX1_27514584_Chip-Seq_MCF-7_Human1.84035304
25ZFP281_18757296_ChIP-ChIP_E14_Mouse1.81627179
26CTCF_27219007_Chip-Seq_Bcells_Human1.76400918
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.73187273
28CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.72333926
29STAT3_1855785_ChIP-Seq_MESCs_Mouse1.66310308
30AR_21572438_ChIP-Seq_LNCaP_Human1.63997084
31GATA4_21415370_ChIP-Seq_HL-1_Mouse1.63952430
32ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.62436543
33TP63_22573176_ChIP-Seq_HFKS_Human1.58901699
34HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.57670215
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57314946
36SOX2_27498859_Chip-Seq_STOMACH_Mouse1.57231054
37ESR1_15608294_ChIP-ChIP_MCF-7_Human1.53875130
38EP300_21415370_ChIP-Seq_HL-1_Mouse1.53130902
39* ESR1_21235772_ChIP-Seq_MCF-7_Human1.51076981
40* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.48716050
41RAD21_21589869_ChIP-Seq_MESCs_Mouse1.47387537
42NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.46083277
43KDM2B_26808549_Chip-Seq_DND41_Human1.44973032
44YY1_22570637_ChIP-Seq_MALME-3M_Human1.43634473
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.43138829
46PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.41066182
47FOXH1_21741376_ChIP-Seq_ESCs_Human1.40049918
48TDRD3_21172665_ChIP-Seq_MCF-7_Human1.38831427
49SA1_27219007_Chip-Seq_Bcells_Human1.37281726
50BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.37273305
51FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.37020205
52CTCF_21964334_Chip-Seq_Bcells_Human1.35907468
53SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.35023474
54DNAJC2_21179169_ChIP-ChIP_NT2_Human1.32365230
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30832957
56ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.30608926
57SOX9_24532713_ChIP-Seq_HFSC_Mouse1.30164068
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.28949133
59SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28004194
60STAT1_20625510_ChIP-Seq_HELA_Human1.27943298
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.25325849
62CREB1_26743006_Chip-Seq_LNCaP_Human1.22846550
63EZH2_22144423_ChIP-Seq_EOC_Human1.21984922
64SA1_27219007_Chip-Seq_ERYTHROID_Human1.21950732
65NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.20469213
66RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19765541
67KLF5_25053715_ChIP-Seq_YYC3_Human1.19716442
68VDR_22108803_ChIP-Seq_LS180_Human1.19379909
69CLOCK_20551151_ChIP-Seq_293T_Human1.18982274
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18469836
71SMC3_22415368_ChIP-Seq_MEFs_Mouse1.18416164
72OCT4_20526341_ChIP-Seq_ESCs_Human1.17503730
73HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16121045
74RAC3_21632823_ChIP-Seq_H3396_Human1.15616945
75AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.15347760
76* EZH2_27294783_Chip-Seq_ESCs_Mouse1.14862899
77TP63_17297297_ChIP-ChIP_HaCaT_Human1.14694639
78ATF3_27146783_Chip-Seq_COLON_Human1.14013126
79SMC1_22415368_ChIP-Seq_MEFs_Mouse1.13612581
80ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13142547
81SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12887891
82CTNNB1_20460455_ChIP-Seq_HCT116_Human1.12506472
83PHF8_20622854_ChIP-Seq_HELA_Human1.10858019
84SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.08965493
85WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08026756
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.07741505
87SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07386078
88MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.07334789
89CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06701753
90PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06196842
91RACK7_27058665_Chip-Seq_MCF-7_Human1.05755013
92TP53_20018659_ChIP-ChIP_R1E_Mouse1.04848941
93NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04422973
94P68_20966046_ChIP-Seq_HELA_Human1.03334237
95NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.03311327
96P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03016605
97STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02507700
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01842207
99SPI1_20517297_ChIP-Seq_HL60_Human1.01469517
100MYC_27129775_Chip-Seq_CORNEA_Mouse1.01282047
101CTCF_26484167_Chip-Seq_Bcells_Mouse1.01012995
102AHR_22903824_ChIP-Seq_MCF-7_Human1.00393233
103CBP_20019798_ChIP-Seq_JUKART_Human1.00193049
104IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00193049
105STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99404525
106E2F1_20622854_ChIP-Seq_HELA_Human0.98837659
107FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98833850
108TP63_23658742_ChIP-Seq_EP156T_Human0.98793559
109CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98514563
110BCOR_27268052_Chip-Seq_Bcells_Human0.98352886
111RXR_22158963_ChIP-Seq_LIVER_Mouse0.98333100
112RARB_27405468_Chip-Seq_BRAIN_Mouse0.98332930
113TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98281929
114LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.95645868
115NANOG_20526341_ChIP-Seq_ESCs_Human0.95397985
116KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95150561
117DROSHA_22980978_ChIP-Seq_HELA_Human0.94713776
118FLI1_21867929_ChIP-Seq_CD8_Mouse0.93564010
119ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.93526406
120FOXA2_19822575_ChIP-Seq_HepG2_Human0.92593513
121GATA1_19941826_ChIP-Seq_K562_Human0.92412394
122FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.92226167
123GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.91964067
124SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.91399862
125LXR_22158963_ChIP-Seq_LIVER_Mouse0.91339001
126GATA1_19941827_ChIP-Seq_MEL_Mouse0.91158108
127CTCF_20526341_ChIP-Seq_ESCs_Human0.89548213
128SOX2_20726797_ChIP-Seq_SW620_Human0.89270953
129GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.89001743
130STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.87844648
131* TP53_23651856_ChIP-Seq_MEFs_Mouse0.87164253
132GATA3_24758297_ChIP-Seq_MCF-7_Human0.86549287
133EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.86405370
134SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86165305
135CEBPB_22108803_ChIP-Seq_LS180_Human0.86093024
136KLF4_19829295_ChIP-Seq_ESCs_Human0.85696883
137P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.85230867
138KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84973352
139BCL6_27268052_Chip-Seq_Bcells_Human0.84728712
140ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84489561
141ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.84136651
142CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.84011526
143* TCF7_22412390_ChIP-Seq_EML_Mouse0.83665059
144SOX2_21211035_ChIP-Seq_LN229_Human0.83524734
145P300_27058665_Chip-Seq_ZR-75-30cells_Human0.83425068
146ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.83409859
147PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.82827934
148ETV1_20927104_ChIP-Seq_GIST48_Human0.82485622
149EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.82239242
150SMAD3_21741376_ChIP-Seq_HESCs_Human0.81424667
151LXR_22292898_ChIP-Seq_THP-1_Human0.81399084
152OCT1_27270436_Chip-Seq_PROSTATE_Human0.78174528

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio8.03026221
2MP0000749_muscle_degeneration6.37815729
3MP0003646_muscle_fatigue6.12507132
4MP0000751_myopathy5.65364508
5MP0000747_muscle_weakness4.40258701
6MP0002106_abnormal_muscle_physiology4.27446167
7MP0004036_abnormal_muscle_relaxation4.10537874
8MP0008875_abnormal_xenobiotic_pharmacok3.89306361
9MP0000759_abnormal_skeletal_muscle3.86110981
10MP0002269_muscular_atrophy3.68923814
11MP0002837_dystrophic_cardiac_calcinosis3.65865483
12MP0005369_muscle_phenotype3.53123705
13MP0004087_abnormal_muscle_fiber3.50594675
14MP0000750_abnormal_muscle_regeneration3.50263362
15MP0002653_abnormal_ependyma_morphology3.16238038
16MP0004130_abnormal_muscle_cell3.14782483
17MP0005620_abnormal_muscle_contractility3.14208153
18MP0002132_abnormal_respiratory_system3.06940856
19MP0009780_abnormal_chondrocyte_physiolo2.91755241
20MP0004233_abnormal_muscle_weight2.85156382
21MP0005451_abnormal_body_composition2.83514435
22MP0000733_abnormal_muscle_development2.52956326
23MP0002332_abnormal_exercise_endurance2.28165526
24MP0005330_cardiomyopathy2.11799810
25MP0004084_abnormal_cardiac_muscle2.08877882
26MP0002108_abnormal_muscle_morphology1.98103210
27MP0006036_abnormal_mitochondrial_physio1.93621976
28MP0002277_abnormal_respiratory_mucosa1.87748606
29MP0001984_abnormal_olfaction1.86511184
30MP0008789_abnormal_olfactory_epithelium1.83356762
31MP0004270_analgesia1.80479700
32MP0005623_abnormal_meninges_morphology1.78114940
33MP0004215_abnormal_myocardial_fiber1.62401609
34MP0004185_abnormal_adipocyte_glucose1.56724836
35MP0004133_heterotaxia1.56239887
36MP0002972_abnormal_cardiac_muscle1.39460281
37MP0001346_abnormal_lacrimal_gland1.36054969
38MP0010630_abnormal_cardiac_muscle1.33820345
39MP0004484_altered_response_of1.33653276
40MP0003806_abnormal_nucleotide_metabolis1.30799478
41MP0002971_abnormal_brown_adipose1.29880044
42MP0003950_abnormal_plasma_membrane1.28898374
43MP0005666_abnormal_adipose_tissue1.27177270
44MP0003221_abnormal_cardiomyocyte_apopto1.26953153
45MP0005266_abnormal_metabolism1.20794117
46MP0002822_catalepsy1.14268245
47MP0006035_abnormal_mitochondrial_morpho1.09424284
48MP0003137_abnormal_impulse_conducting1.05291902
49MP0001765_abnormal_ion_homeostasis1.01175429
50MP0005385_cardiovascular_system_phenoty0.98900297
51MP0001544_abnormal_cardiovascular_syste0.98900297
52MP0002168_other_aberrant_phenotype0.98829846
53MP0005377_hearing/vestibular/ear_phenot0.96028697
54MP0003878_abnormal_ear_physiology0.96028697
55MP0005165_increased_susceptibility_to0.95196002
56MP0005375_adipose_tissue_phenotype0.93284171
57MP0000678_abnormal_parathyroid_gland0.91087164
58MP0000013_abnormal_adipose_tissue0.85992828
59MP0000383_abnormal_hair_follicle0.85227190
60MP0000372_irregular_coat_pigmentation0.82942907
61MP0008961_abnormal_basal_metabolism0.82080627
62MP0003705_abnormal_hypodermis_morpholog0.80020587
63MP0005248_abnormal_Harderian_gland0.75699405
64MP0010678_abnormal_skin_adnexa0.74264779
65MP0004134_abnormal_chest_morphology0.73777915
66MP0002127_abnormal_cardiovascular_syste0.71357352
67MP0002234_abnormal_pharynx_morphology0.70222838
68MP0000566_synostosis0.69563340
69MP0004019_abnormal_vitamin_homeostasis0.67625822
70MP0000762_abnormal_tongue_morphology0.65553309
71MP0009250_abnormal_appendicular_skeleto0.65036934
72MP0008775_abnormal_heart_ventricle0.64744789
73MP0005499_abnormal_olfactory_system0.64483734
74MP0005394_taste/olfaction_phenotype0.64483734
75MP0009379_abnormal_foot_pigmentation0.62980454
76MP0000266_abnormal_heart_morphology0.62685812
77MP0001299_abnormal_eye_distance/0.60557597
78MP0004043_abnormal_pH_regulation0.60427167
79MP0010234_abnormal_vibrissa_follicle0.57908032
80MP0003879_abnormal_hair_cell0.55651565
81MP0002160_abnormal_reproductive_system0.54253130
82MP0002282_abnormal_trachea_morphology0.53877239
83MP0004147_increased_porphyrin_level0.53357639
84MP0005636_abnormal_mineral_homeostasis0.53088782
85MP0006138_congestive_heart_failure0.52541796
86MP0002078_abnormal_glucose_homeostasis0.51113932
87MP0005166_decreased_susceptibility_to0.50326602
88MP0005334_abnormal_fat_pad0.50166440
89MP0002638_abnormal_pupillary_reflex0.49799819
90MP0000003_abnormal_adipose_tissue0.49604006
91MP0003828_pulmonary_edema0.48763731
92MP0003567_abnormal_fetal_cardiomyocyte0.47758432
93MP0003959_abnormal_lean_body0.46305961
94MP0003656_abnormal_erythrocyte_physiolo0.45583996
95MP0002114_abnormal_axial_skeleton0.45287755
96MP0004142_abnormal_muscle_tone0.44913540
97MP0005452_abnormal_adipose_tissue0.44688687
98MP0008569_lethality_at_weaning0.44386873
99MP0004858_abnormal_nervous_system0.43493669
100MP0009672_abnormal_birth_weight0.42728331
101MP0010155_abnormal_intestine_physiology0.42123967
102MP0000467_abnormal_esophagus_morphology0.41790557
103MP0005670_abnormal_white_adipose0.40736401
104MP0002909_abnormal_adrenal_gland0.40233313
105MP0004085_abnormal_heartbeat0.40172116
106MP0005083_abnormal_biliary_tract0.39944609
107MP0004197_abnormal_fetal_growth/weight/0.38440753
108MP0000343_altered_response_to0.38132225
109MP0002876_abnormal_thyroid_physiology0.37925592
110MP0005275_abnormal_skin_tensile0.36968813
111MP0003191_abnormal_cellular_cholesterol0.34660915
112MP0002089_abnormal_postnatal_growth/wei0.34204074
113MP0005584_abnormal_enzyme/coenzyme_acti0.31698442
114MP0001849_ear_inflammation0.29865338
115MP0002896_abnormal_bone_mineralization0.29816984
116MP0003948_abnormal_gas_homeostasis0.28785883
117MP0001943_abnormal_respiration0.28082052
118MP0008770_decreased_survivor_rate0.27477339
119MP0003385_abnormal_body_wall0.27127568
120MP0005376_homeostasis/metabolism_phenot0.26858363
121MP0004859_abnormal_synaptic_plasticity0.26327933
122MP0010030_abnormal_orbit_morphology0.25860842
123MP0003755_abnormal_palate_morphology0.25649017
124MP0005319_abnormal_enzyme/_coenzyme0.25232123
125MP0004510_myositis0.24665945
126MP0005076_abnormal_cell_differentiation0.22806924
127MP0002932_abnormal_joint_morphology0.21903915
128MP0002066_abnormal_motor_capabilities/c0.21861964
129MP0002128_abnormal_blood_circulation0.21134159
130MP0002249_abnormal_larynx_morphology0.18789412
131MP0001730_embryonic_growth_arrest0.18361200
132MP0002734_abnormal_mechanical_nocicepti0.17721663
133MP0003045_fibrosis0.16989830
134MP0009115_abnormal_fat_cell0.16563001
135MP0000230_abnormal_systemic_arterial0.15931054
136MP0003956_abnormal_body_size0.14939413
137MP0002081_perinatal_lethality0.14739944
138MP0002925_abnormal_cardiovascular_devel0.14370349
139MP0003941_abnormal_skin_development0.14069520

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.78419749
2Muscle fiber inclusion bodies (HP:0100299)9.77345973
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)9.39539787
4Abnormal respiratory epithelium morphology (HP:0012253)8.97642702
5Abnormal respiratory motile cilium morphology (HP:0005938)8.97642702
6Nemaline bodies (HP:0003798)8.84066228
7Abnormal respiratory motile cilium physiology (HP:0012261)8.60689073
8Absent/shortened dynein arms (HP:0200106)8.45596774
9Dynein arm defect of respiratory motile cilia (HP:0012255)8.45596774
10Exercise-induced myalgia (HP:0003738)8.39961626
11Abnormal ciliary motility (HP:0012262)8.35332124
12Rhinitis (HP:0012384)7.89765512
13Exercise-induced muscle cramps (HP:0003710)7.83440791
14Distal arthrogryposis (HP:0005684)7.45892727
15Type 1 muscle fiber predominance (HP:0003803)7.23330206
16Muscle hypertrophy of the lower extremities (HP:0008968)7.01070777
17Round ear (HP:0100830)6.53452941
18Myopathic facies (HP:0002058)6.50852708
19Chronic bronchitis (HP:0004469)6.30411947
20Calf muscle hypertrophy (HP:0008981)6.26503112
21Ulnar deviation of the wrist (HP:0003049)6.25812164
22Bronchiectasis (HP:0002110)5.85088030
23Nasal polyposis (HP:0100582)5.54587385
24Difficulty running (HP:0009046)5.51665817
25Calcaneovalgus deformity (HP:0001848)5.47445068
26Muscle fiber splitting (HP:0003555)5.20706188
27Myoglobinuria (HP:0002913)5.06217309
28Absent phalangeal crease (HP:0006109)5.04122706
29Deformed tarsal bones (HP:0008119)4.95013888
30Hyporeflexia of lower limbs (HP:0002600)4.68839429
31Abnormality of the nasal mucosa (HP:0000433)4.65427577
32Muscle stiffness (HP:0003552)4.61478811
33EMG: myopathic abnormalities (HP:0003458)4.53616475
34Rhabdomyolysis (HP:0003201)4.30120150
35Abnormality of the calf musculature (HP:0001430)4.27437560
36Abnormal finger flexion creases (HP:0006143)4.21341440
37Increased connective tissue (HP:0009025)4.17740502
38Myotonia (HP:0002486)4.08664001
39Malignant hyperthermia (HP:0002047)3.81805986
40Abnormality of the left ventricular outflow tract (HP:0011103)3.78920509
41Subaortic stenosis (HP:0001682)3.78920509
42Abnormality of skeletal muscle fiber size (HP:0012084)3.64331860
43Difficulty climbing stairs (HP:0003551)3.59305950
44Infertility (HP:0000789)3.47116908
45Rimmed vacuoles (HP:0003805)3.45536810
46Shoulder girdle muscle weakness (HP:0003547)3.43698569
47Neck muscle weakness (HP:0000467)3.41332583
48Abnormality of the calcaneus (HP:0008364)3.37834961
49Pelvic girdle muscle weakness (HP:0003749)3.33116734
50Bronchitis (HP:0012387)3.27961186
51Abnormality of the hip-girdle musculature (HP:0001445)3.21947083
52Abnormality of the musculature of the pelvis (HP:0001469)3.21947083
53Increased variability in muscle fiber diameter (HP:0003557)3.21822515
54Recurrent sinusitis (HP:0011108)3.18644035
55Areflexia of lower limbs (HP:0002522)3.11173182
56Male infertility (HP:0003251)3.10288436
57Chronic sinusitis (HP:0011109)3.09515624
58Frequent falls (HP:0002359)3.01558181
59Recurrent otitis media (HP:0000403)2.92954856
60Sudden death (HP:0001699)2.88786385
61Asymmetric septal hypertrophy (HP:0001670)2.86895554
62Hyperkalemia (HP:0002153)2.73297078
63Abnormality of the neuromuscular junction (HP:0003398)2.71033194
64Fatigable weakness (HP:0003473)2.71033194
65Atelectasis (HP:0100750)2.67944885
66EMG: neuropathic changes (HP:0003445)2.59862279
67Slender build (HP:0001533)2.55958997
68Hyperactive renin-angiotensin system (HP:0000841)2.54757633
69Distal lower limb muscle weakness (HP:0009053)2.53146342
70Occipital encephalocele (HP:0002085)2.44963500
71Paralysis (HP:0003470)2.43039104
72Hypoplastic ischia (HP:0003175)2.33954761
73Generalized muscle weakness (HP:0003324)2.33891226
74Bulbar palsy (HP:0001283)2.33257550
75Mildly elevated creatine phosphokinase (HP:0008180)2.32554939
76Muscular dystrophy (HP:0003560)2.32104480
77Fetal akinesia sequence (HP:0001989)2.31147133
78Limb-girdle muscle weakness (HP:0003325)2.29982977
79Proximal amyotrophy (HP:0007126)2.26728027
80Gowers sign (HP:0003391)2.22393145
81Chronic otitis media (HP:0000389)2.17522891
82Popliteal pterygium (HP:0009756)2.16145393
83Abnormality of the shoulder girdle musculature (HP:0001435)2.15478024
84Nonprogressive disorder (HP:0003680)2.14443101
85Weak cry (HP:0001612)2.13423285
86Metatarsus adductus (HP:0001840)2.10862329
87Centrally nucleated skeletal muscle fibers (HP:0003687)2.10201994
88Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.08951876
89Progressive muscle weakness (HP:0003323)2.06687174
90Ulnar deviation of finger (HP:0009465)2.05896642
91Pancreatic fibrosis (HP:0100732)2.05434195
92Abnormality of the ischium (HP:0003174)2.03290830
93Scapular winging (HP:0003691)2.00000784
94Facial diplegia (HP:0001349)1.98244561
95True hermaphroditism (HP:0010459)1.96902630
96Distal lower limb amyotrophy (HP:0008944)1.95727489
97Spinal rigidity (HP:0003306)1.93609555
98Bell-shaped thorax (HP:0001591)1.92896279
99Limb-girdle muscle atrophy (HP:0003797)1.92650532
100Hip contracture (HP:0003273)1.88999369
101Ventricular tachycardia (HP:0004756)1.85338465
102Increased density of long bones (HP:0006392)1.80907477
103Waddling gait (HP:0002515)1.74955039
104Achilles tendon contracture (HP:0001771)1.74721638
105Cystic liver disease (HP:0006706)1.70971372
106Bundle branch block (HP:0011710)1.69329888
107Abnormality of midbrain morphology (HP:0002418)1.65647979
108Molar tooth sign on MRI (HP:0002419)1.65647979
109Nephronophthisis (HP:0000090)1.63925737
110Tarsal synostosis (HP:0008368)1.61666689
111Type 2 muscle fiber atrophy (HP:0003554)1.61519764
112Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.60899187
113Respiratory insufficiency due to muscle weakness (HP:0002747)1.60184753
114Short palpebral fissure (HP:0012745)1.58563035
115Abnormality of the Achilles tendon (HP:0005109)1.56918496
116Lipoatrophy (HP:0100578)1.55453414
117Long clavicles (HP:0000890)1.54240736
118Adducted thumb (HP:0001181)1.51793687
119Muscle fiber atrophy (HP:0100295)1.50075491
120Dilated cardiomyopathy (HP:0001644)1.47697860
121Exercise intolerance (HP:0003546)1.47445262
122Congenital hip dislocation (HP:0001374)1.46725707
123Hyperuricemia (HP:0002149)1.46712760
124Increased purine levels (HP:0004368)1.46712760
125Cholelithiasis (HP:0001081)1.46638194
126Lower limb amyotrophy (HP:0007210)1.46554011
127Synostosis involving bones of the feet (HP:0009140)1.46086496
128Synostosis involving bones of the lower limbs (HP:0009138)1.46086496
129Postaxial foot polydactyly (HP:0001830)1.44075652
130Pancreatic cysts (HP:0001737)1.43906025
131Aplasia of the musculature (HP:0100854)1.43626809
132Renal salt wasting (HP:0000127)1.41654443
133Stridor (HP:0010307)1.41074668
134Hyponatremia (HP:0002902)1.40254289
135Aplasia/Hypoplasia of the spleen (HP:0010451)1.39156513
136Congenital hepatic fibrosis (HP:0002612)1.39007289
137Wrist flexion contracture (HP:0001239)1.37546413
138Decreased circulating renin level (HP:0003351)1.36610306
139Asplenia (HP:0001746)1.36145131
140Abnormality of potassium homeostasis (HP:0011042)1.36142838

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN8.45581169
2MAPK156.55164165
3TTN6.40252366
4PHKG15.47588909
5PHKG25.47588909
6NME14.37232511
7EPHA23.70243951
8PIK3CG3.55281577
9NEK12.97667760
10MAP2K32.84891776
11MST42.68428209
12PINK12.17271248
13PDK32.10330671
14PDK42.10330671
15MAP3K72.09707480
16DMPK1.80972770
17TRIB31.80069606
18MAP2K41.70807450
19MAPK121.68199526
20BCKDK1.60364094
21SMG11.58880471
22PIK3CA1.51710570
23MUSK1.47787416
24MAP2K61.40492598
25PDK21.39330873
26PKN21.06813582
27MST1R1.04771210
28ERBB30.94979112
29MARK20.94251713
30MAPKAPK30.84082984
31CSK0.83430544
32PRKAA10.83127713
33PRKAA20.82347873
34STK240.79604807
35MAP3K20.78778251
36TBK10.78047936
37NEK90.69828306
38AKT20.68571130
39ZAK0.64690210
40TAOK20.63598321
41MOS0.61722988
42MAP3K130.61104605
43MAP3K30.60816262
44LATS20.59742139
45TESK10.58651851
46NEK60.56377861
47ILK0.55514245
48TRPM70.55212739
49MAP3K120.54901739
50MAPK110.54098965
51STK160.54043411
52PNCK0.51885911
53STK380.50316219
54CAMK2G0.49293846
55KSR20.45807979
56STK100.45754703
57TTK0.44995925
58LIMK10.42324817
59MAP3K100.40903559
60ARAF0.39365962
61HIPK20.38995130
62MAP3K110.38091555
63EEF2K0.36849636
64MAP3K50.34574023
65TAOK10.34144795
66PRKACB0.32955946
67PRKCI0.32924886
68PTK60.32751163
69CDK190.32737606
70MAP3K60.32716053
71SGK10.32429838
72MAPK70.29485273
73RPS6KA30.27879572
74ZAP700.27332070
75MAP2K10.27090142
76EPHA30.26619635
77SGK30.26325575
78KSR10.25044320
79ERN10.24828103
80MET0.24296354
81PRKG10.24285007
82PAK60.24028665
83CCNB10.23681071
84CAMK40.23128739
85MAP3K90.21867228
86FLT30.21316371
87CDC42BPA0.20968400
88PKN10.18879061
89ROCK10.18386749
90RIPK10.18203781
91MAP2K20.17981982
92PRKCQ0.17858843
93MAP3K40.17841314
94PRKACA0.17772316
95CAMK2B0.17109561
96LATS10.16347924
97SIK10.14653529
98RPS6KB10.14491901
99TIE10.14449322
100EPHB10.14381746
101MTOR0.14274479
102PAK10.14135399
103RPS6KB20.13942476
104ICK0.13617343
105RPS6KA20.13253427
106CAMK1G0.12505867
107PDK10.11145495
108PTK20.11056059
109MAP3K10.10909598
110ERBB20.10903102
111CSNK1D0.10692645
112MAPK100.10638387
113MAPK40.10208578
114FGFR10.09385800
115RPS6KA10.08717516
116PRKD10.07730284
117LRRK20.07456064
118ROCK20.07388038
119PDPK10.07331814
120PRKDC0.07046379
121STK110.05796525
122CAMK2D0.04865223
123RAF10.04701294
124DYRK1B0.03563898
125MAP3K80.03187639
126PRKACG0.02801801
127MAPK80.02634026
128STK38L0.02510889
129BMX0.01247849
130CAMK2A0.00535014
131MAPK9-0.0255501
132CDK12-0.0167348
133PTK2B-0.0115703
134INSRR-0.0093179
135CSNK1E-0.0037334
136PAK4-0.0022539

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.77767777
2* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.00599221
3Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.86865050
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.81024060
5Histidine metabolism_Homo sapiens_hsa003403.76194136
6* Cardiac muscle contraction_Homo sapiens_hsa042603.60406553
7* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.32597017
8Tyrosine metabolism_Homo sapiens_hsa003503.30895274
9* Dilated cardiomyopathy_Homo sapiens_hsa054143.25132895
10Chemical carcinogenesis_Homo sapiens_hsa052043.06904418
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.82434587
12Starch and sucrose metabolism_Homo sapiens_hsa005002.70965648
13Glucagon signaling pathway_Homo sapiens_hsa049222.52091753
14Carbon metabolism_Homo sapiens_hsa012002.44410231
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.37691109
16Circadian rhythm_Homo sapiens_hsa047102.27543539
17Propanoate metabolism_Homo sapiens_hsa006402.27402649
18Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.25644966
19Insulin signaling pathway_Homo sapiens_hsa049102.22709403
20Parkinsons disease_Homo sapiens_hsa050122.15515602
21* Oxytocin signaling pathway_Homo sapiens_hsa049212.12428888
22Glutathione metabolism_Homo sapiens_hsa004802.06641905
23Insulin resistance_Homo sapiens_hsa049311.89519399
24Alzheimers disease_Homo sapiens_hsa050101.86243488
25Biosynthesis of amino acids_Homo sapiens_hsa012301.84555885
26Oxidative phosphorylation_Homo sapiens_hsa001901.83738604
27Calcium signaling pathway_Homo sapiens_hsa040201.78216731
28AMPK signaling pathway_Homo sapiens_hsa041521.73232560
29Galactose metabolism_Homo sapiens_hsa000521.72889700
30* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72580470
31Fructose and mannose metabolism_Homo sapiens_hsa000511.68530781
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.61784419
33Tight junction_Homo sapiens_hsa045301.52831850
34Adipocytokine signaling pathway_Homo sapiens_hsa049201.52755863
35Pyruvate metabolism_Homo sapiens_hsa006201.52412578
36Viral myocarditis_Homo sapiens_hsa054161.47798036
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40246216
38Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.31988042
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.28235390
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.27620079
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.24562494
42Arginine and proline metabolism_Homo sapiens_hsa003301.22573268
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21878421
44Retinol metabolism_Homo sapiens_hsa008301.19242535
45Fatty acid degradation_Homo sapiens_hsa000711.19017776
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.12623557
47Huntingtons disease_Homo sapiens_hsa050161.10507561
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10367203
49GnRH signaling pathway_Homo sapiens_hsa049121.03943062
50Central carbon metabolism in cancer_Homo sapiens_hsa052301.03940778
51Pentose phosphate pathway_Homo sapiens_hsa000301.03729283
52Gastric acid secretion_Homo sapiens_hsa049710.96659520
53Focal adhesion_Homo sapiens_hsa045100.96437847
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93245097
55FoxO signaling pathway_Homo sapiens_hsa040680.92293940
56Longevity regulating pathway - mammal_Homo sapiens_hsa042110.90142063
57HIF-1 signaling pathway_Homo sapiens_hsa040660.89739439
58mTOR signaling pathway_Homo sapiens_hsa041500.87475841
59Linoleic acid metabolism_Homo sapiens_hsa005910.86104700
60Peroxisome_Homo sapiens_hsa041460.85826753
61Salivary secretion_Homo sapiens_hsa049700.85495451
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82796610
63Notch signaling pathway_Homo sapiens_hsa043300.82774046
64Arginine biosynthesis_Homo sapiens_hsa002200.79276805
65Fatty acid metabolism_Homo sapiens_hsa012120.78269696
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77250858
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77149123
68Caffeine metabolism_Homo sapiens_hsa002320.74089824
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73329463
70Renin secretion_Homo sapiens_hsa049240.70737119
71VEGF signaling pathway_Homo sapiens_hsa043700.70349352
72ABC transporters_Homo sapiens_hsa020100.58645831
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.54415447
74* MAPK signaling pathway_Homo sapiens_hsa040100.53697551
75Adherens junction_Homo sapiens_hsa045200.53507578
76Insulin secretion_Homo sapiens_hsa049110.52984579
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47602416
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.47592237
79Long-term potentiation_Homo sapiens_hsa047200.44783654
80Oocyte meiosis_Homo sapiens_hsa041140.42661957
81Platelet activation_Homo sapiens_hsa046110.42443662
82Arachidonic acid metabolism_Homo sapiens_hsa005900.39871151
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.39206032
84Choline metabolism in cancer_Homo sapiens_hsa052310.38304219
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36895861
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36509128
87Proteoglycans in cancer_Homo sapiens_hsa052050.36223392
88Fatty acid biosynthesis_Homo sapiens_hsa000610.35810465
89Hepatitis C_Homo sapiens_hsa051600.34889830
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.33989604
91cAMP signaling pathway_Homo sapiens_hsa040240.33518274
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32170149
93Long-term depression_Homo sapiens_hsa047300.31805318
94Type II diabetes mellitus_Homo sapiens_hsa049300.31517811
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31115971
96Amoebiasis_Homo sapiens_hsa051460.30652679
97beta-Alanine metabolism_Homo sapiens_hsa004100.29947544
98Butanoate metabolism_Homo sapiens_hsa006500.29520557
99Renal cell carcinoma_Homo sapiens_hsa052110.28893564
100Hedgehog signaling pathway_Homo sapiens_hsa043400.27664221
101Olfactory transduction_Homo sapiens_hsa047400.27180149
102Cholinergic synapse_Homo sapiens_hsa047250.27103907
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26072074
104Purine metabolism_Homo sapiens_hsa002300.23916679
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23377896
106Gap junction_Homo sapiens_hsa045400.21959318
107Regulation of autophagy_Homo sapiens_hsa041400.21792183
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.20565760
109Melanogenesis_Homo sapiens_hsa049160.19791405
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.18380490
111Circadian entrainment_Homo sapiens_hsa047130.17927401
112PPAR signaling pathway_Homo sapiens_hsa033200.17684851
113Nitrogen metabolism_Homo sapiens_hsa009100.17137971
114Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.16580619
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.16525222
116Ovarian steroidogenesis_Homo sapiens_hsa049130.14874430
117Sphingolipid metabolism_Homo sapiens_hsa006000.14662088
118Tryptophan metabolism_Homo sapiens_hsa003800.10624911
119Amphetamine addiction_Homo sapiens_hsa050310.10533225
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.10285303
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.09336019
122Basal cell carcinoma_Homo sapiens_hsa052170.09254919
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.09211953
124RNA degradation_Homo sapiens_hsa030180.08848044
125Hippo signaling pathway_Homo sapiens_hsa043900.08484818
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.08469790
127Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.08053258
128Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.07959803
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.07620315
130Metabolic pathways_Homo sapiens_hsa011000.07578194
131Phenylalanine metabolism_Homo sapiens_hsa003600.06269044
132Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.05668896
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.05648053
134Wnt signaling pathway_Homo sapiens_hsa043100.05606385
135Proteasome_Homo sapiens_hsa030500.04279809
136Lysine degradation_Homo sapiens_hsa003100.02793693
137Glioma_Homo sapiens_hsa052140.02206989

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