CACNG4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)6.70285439
2axon ensheathment in central nervous system (GO:0032291)5.11710286
3central nervous system myelination (GO:0022010)5.11710286
4locomotory exploration behavior (GO:0035641)4.98896525
5presynaptic membrane assembly (GO:0097105)4.95634265
6vocalization behavior (GO:0071625)4.74728325
7dendritic spine morphogenesis (GO:0060997)4.62449519
8postsynaptic membrane organization (GO:0001941)4.61587688
9presynaptic membrane organization (GO:0097090)4.56212466
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.55827059
11* regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.51311347
12neuron recognition (GO:0008038)4.49178295
13ear development (GO:0043583)4.43216799
14adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.31441750
15protein localization to synapse (GO:0035418)4.30117115
16regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.27274125
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.23420670
18layer formation in cerebral cortex (GO:0021819)4.10427807
19pyrimidine nucleobase catabolic process (GO:0006208)4.03815001
20auditory behavior (GO:0031223)4.03364847
21exploration behavior (GO:0035640)3.98393215
22regulation of short-term neuronal synaptic plasticity (GO:0048172)3.83839992
23axonal fasciculation (GO:0007413)3.81648550
24* regulation of glutamate receptor signaling pathway (GO:1900449)3.81347873
25apical protein localization (GO:0045176)3.69661427
26dendrite morphogenesis (GO:0048813)3.69533425
27regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.69427207
28glutamate receptor signaling pathway (GO:0007215)3.63043903
29positive regulation of synapse assembly (GO:0051965)3.61781295
30cerebral cortex radially oriented cell migration (GO:0021799)3.59702912
31negative regulation of protein localization to cell surface (GO:2000009)3.59669298
32regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.53220721
33synaptic transmission, glutamatergic (GO:0035249)3.52621922
34cell migration in hindbrain (GO:0021535)3.49078558
35negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.46339862
36positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.45958677
37positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.44855344
38startle response (GO:0001964)3.43571225
39limb bud formation (GO:0060174)3.39381653
40mechanosensory behavior (GO:0007638)3.36395038
41neurotransmitter-gated ion channel clustering (GO:0072578)3.36071628
42dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.35201198
43central nervous system projection neuron axonogenesis (GO:0021952)3.32308514
44establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.30825584
45mitochondrion transport along microtubule (GO:0047497)3.30825584
46neuron-neuron synaptic transmission (GO:0007270)3.28367841
47negative regulation of neurotransmitter transport (GO:0051589)3.25848660
48regulation of synapse structural plasticity (GO:0051823)3.25047204
49response to auditory stimulus (GO:0010996)3.24105016
50synaptic vesicle maturation (GO:0016188)3.22567736
51regulation of dendritic spine morphogenesis (GO:0061001)3.22427931
52neuronal action potential propagation (GO:0019227)3.22120189
53gamma-aminobutyric acid transport (GO:0015812)3.19667424
54adult walking behavior (GO:0007628)3.19519115
55synaptic vesicle exocytosis (GO:0016079)3.18699844
56innervation (GO:0060384)3.16006547
57regulation of synaptic transmission, glutamatergic (GO:0051966)3.16000686
58synapse assembly (GO:0007416)3.14946962
59regulation of respiratory system process (GO:0044065)3.14931071
60L-amino acid import (GO:0043092)3.13650093
61negative regulation of axon extension (GO:0030517)3.11412186
62positive regulation of synaptic transmission, GABAergic (GO:0032230)3.11357832
63negative regulation of synaptic transmission, GABAergic (GO:0032229)3.10292288
64embryonic camera-type eye morphogenesis (GO:0048596)3.09899141
65asymmetric protein localization (GO:0008105)3.09501703
66nucleobase catabolic process (GO:0046113)3.08251554
67* transmission of nerve impulse (GO:0019226)3.07823453
68positive regulation of membrane potential (GO:0045838)3.07304846
69semaphorin-plexin signaling pathway (GO:0071526)3.06612590
70axon extension (GO:0048675)3.05627607
71negative regulation of axon extension involved in axon guidance (GO:0048843)3.03648427
72regulation of long-term neuronal synaptic plasticity (GO:0048169)3.03593323
73establishment of mitochondrion localization (GO:0051654)3.03265057
74regulation of neuronal synaptic plasticity (GO:0048168)3.03020623
75positive regulation of dendritic spine development (GO:0060999)3.02984513
76regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.01922451
77cerebellar granule cell differentiation (GO:0021707)3.01508481
78regulation of synaptic vesicle exocytosis (GO:2000300)3.00923225
79dopamine receptor signaling pathway (GO:0007212)2.99432170
80norepinephrine metabolic process (GO:0042415)2.98772144
81prepulse inhibition (GO:0060134)2.97530600
82regulation of excitatory postsynaptic membrane potential (GO:0060079)2.97283358
83long-chain fatty acid biosynthetic process (GO:0042759)2.93259603
84regulation of respiratory gaseous exchange (GO:0043576)2.91253240
85negative regulation of neurotransmitter secretion (GO:0046929)2.91099341
86embryonic retina morphogenesis in camera-type eye (GO:0060059)2.90968170
87mesenchyme morphogenesis (GO:0072132)2.90387398
88myelination (GO:0042552)2.90281468
89negative regulation of axon guidance (GO:1902668)2.89684699
90establishment of nucleus localization (GO:0040023)2.89508790
91axon extension involved in axon guidance (GO:0048846)2.89120417
92neuron projection extension involved in neuron projection guidance (GO:1902284)2.89120417
93long-term synaptic potentiation (GO:0060291)2.88267821
94regulation of dendritic spine development (GO:0060998)2.87985514
95synapse organization (GO:0050808)2.86370276
96planar cell polarity pathway involved in neural tube closure (GO:0090179)2.86085520
97neuronal ion channel clustering (GO:0045161)2.84679003
98righting reflex (GO:0060013)2.84517174
99regulation of postsynaptic membrane potential (GO:0060078)2.83912129
100regulation of synapse assembly (GO:0051963)2.82820764
101long-term memory (GO:0007616)2.82803832
102membrane hyperpolarization (GO:0060081)2.81869707
103axon ensheathment (GO:0008366)2.81815193
104ensheathment of neurons (GO:0007272)2.81815193
105cerebellar Purkinje cell layer development (GO:0021680)2.79140450
106negative regulation of axonogenesis (GO:0050771)2.78691121
107cell-cell junction maintenance (GO:0045217)2.78373974
108calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.78269928
109dendrite development (GO:0016358)2.77786501
110amino acid import (GO:0043090)2.76900727
111dendritic spine organization (GO:0097061)2.76866617
112neurotransmitter secretion (GO:0007269)2.75348433
113retina layer formation (GO:0010842)2.74062102
114mating behavior (GO:0007617)2.73857203
115short-term memory (GO:0007614)2.72979938
116regulation of cell proliferation involved in kidney development (GO:1901722)2.72942166
117regulation of axon extension involved in axon guidance (GO:0048841)2.72728975
118oligodendrocyte differentiation (GO:0048709)2.69174321
119spinal cord development (GO:0021510)2.69036088
120central nervous system neuron axonogenesis (GO:0021955)2.69035866
121neuromuscular process controlling balance (GO:0050885)2.68978243
122branching involved in salivary gland morphogenesis (GO:0060445)2.66339194
123regulation of axon guidance (GO:1902667)2.66220066
124G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.65536818
125neuron remodeling (GO:0016322)2.65107523
126regulation of synaptic transmission, GABAergic (GO:0032228)2.64457394
127embryonic eye morphogenesis (GO:0048048)2.64177411
128glutamate secretion (GO:0014047)2.64096815
129membrane assembly (GO:0071709)2.63769097
130camera-type eye morphogenesis (GO:0048593)2.63013359
131enteric nervous system development (GO:0048484)2.62114186
132neuron projection regeneration (GO:0031102)2.60999407
133regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.59523008
134cardiac right ventricle morphogenesis (GO:0003215)2.58564704
135neuron projection extension (GO:1990138)2.58344380
136ectodermal placode formation (GO:0060788)2.57385697
137neurotransmitter catabolic process (GO:0042135)2.50101465
138cellular response to prostaglandin stimulus (GO:0071379)2.47394356
139retinal ganglion cell axon guidance (GO:0031290)2.45787745
140regulation of fatty acid beta-oxidation (GO:0031998)2.44327597
141sympathetic nervous system development (GO:0048485)2.44248067
142maternal placenta development (GO:0001893)2.43176122
143negative regulation of catenin import into nucleus (GO:0035414)2.42461618
144regulation of axonogenesis (GO:0050770)2.41348759
145negative regulation of microtubule polymerization (GO:0031115)2.41025287
146sodium ion export (GO:0071436)2.40335607
147regulation of NFAT protein import into nucleus (GO:0051532)2.39721145
148negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.39674725
149eye morphogenesis (GO:0048592)2.39539378
150RNA localization (GO:0006403)2.39198538
151positive regulation of synapse maturation (GO:0090129)2.37337595
152neuron migration (GO:0001764)2.37242954
153establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.36201630
154body morphogenesis (GO:0010171)2.34809180
155ephrin receptor signaling pathway (GO:0048013)2.34451768
156axon regeneration (GO:0031103)2.34013117
157cell proliferation involved in metanephros development (GO:0072203)2.33672364

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.38152603
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.90163959
3GBX2_23144817_ChIP-Seq_PC3_Human3.77504537
4ESR1_15608294_ChIP-ChIP_MCF-7_Human3.35576224
5ESR2_21235772_ChIP-Seq_MCF-7_Human3.27196250
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.18730817
7ESR1_21235772_ChIP-Seq_MCF-7_Human3.11727438
8* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.06218155
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.97793287
10* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.92533299
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.76722302
12* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.76220092
13* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.76220092
14* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.65248952
15* EED_16625203_ChIP-ChIP_MESCs_Mouse2.64415825
16* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.64049693
17* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.62490431
18AR_21572438_ChIP-Seq_LNCaP_Human2.59410749
19* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58806110
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.46207019
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.39418729
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.32821898
23* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30738343
24* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.25813406
25* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.24747037
26* RNF2_27304074_Chip-Seq_ESCs_Mouse2.24736059
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.22433421
28CBX2_27304074_Chip-Seq_ESCs_Mouse2.18035417
29REST_21632747_ChIP-Seq_MESCs_Mouse2.10096776
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.07396822
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.98067492
32TAF15_26573619_Chip-Seq_HEK293_Human1.97659043
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.91956995
34DROSHA_22980978_ChIP-Seq_HELA_Human1.89955900
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86101553
36* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.83711422
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81479946
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.81425607
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.78848701
40TP63_17297297_ChIP-ChIP_HaCaT_Human1.78705302
41KDM2B_26808549_Chip-Seq_K562_Human1.77778900
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77163144
43WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.75852180
44* RUNX1_27514584_Chip-Seq_MCF-7_Human1.75606578
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73572500
46RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.71163698
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70594723
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68347055
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61016800
50* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.60672647
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57466181
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56289734
53REST_18959480_ChIP-ChIP_MESCs_Mouse1.55940890
54* RARB_27405468_Chip-Seq_BRAIN_Mouse1.54392932
55RNF2_27304074_Chip-Seq_NSC_Mouse1.54262783
56IGF1R_20145208_ChIP-Seq_DFB_Human1.53946904
57* RACK7_27058665_Chip-Seq_MCF-7_Human1.49210064
58SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.49187761
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.48256720
60HIF1A_21447827_ChIP-Seq_MCF-7_Human1.47148252
61* SMAD3_21741376_ChIP-Seq_EPCs_Human1.45390734
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44022290
63P300_19829295_ChIP-Seq_ESCs_Human1.43586237
64SMAD4_21799915_ChIP-Seq_A2780_Human1.42417809
65* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39520019
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.39143597
67THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38581017
68ERG_21242973_ChIP-ChIP_JURKAT_Human1.38528120
69* RING1B_27294783_Chip-Seq_NPCs_Mouse1.38387057
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38112824
71* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37988104
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.36604200
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31951490
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31850746
75TRIM28_21343339_ChIP-Seq_HEK293_Human1.31670755
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30884600
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29554657
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.27591836
79ER_23166858_ChIP-Seq_MCF-7_Human1.24745462
80ZNF274_21170338_ChIP-Seq_K562_Hela1.24357971
81POU5F1_16518401_ChIP-PET_MESCs_Mouse1.24268912
82ZNF263_19887448_ChIP-Seq_K562_Human1.24183273
83FUS_26573619_Chip-Seq_HEK293_Human1.22464833
84PKCTHETA_26484144_Chip-Seq_BREAST_Human1.19896740
85EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19760273
86DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19691395
87IKZF1_21737484_ChIP-ChIP_HCT116_Human1.18728643
88TDRD3_21172665_ChIP-Seq_MCF-7_Human1.18380609
89KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18249522
90NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16255735
91ISL1_27105846_Chip-Seq_CPCs_Mouse1.16206426
92CTCF_27219007_Chip-Seq_Bcells_Human1.15060478
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14776559
94RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14629764
95VDR_22108803_ChIP-Seq_LS180_Human1.14335473
96STAT3_23295773_ChIP-Seq_U87_Human1.12201944
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11819641
98* SOX2_21211035_ChIP-Seq_LN229_Gbm1.11621189
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.10783647
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10589146
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10589146
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10506808
103* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10102939
104LXR_22292898_ChIP-Seq_THP-1_Human1.10070321
105MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08687466
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08464086
107POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06927107
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06307620
109ARNT_22903824_ChIP-Seq_MCF-7_Human1.05552881
110AR_25329375_ChIP-Seq_VCAP_Human1.04772679
111STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04404877
112SMC4_20622854_ChIP-Seq_HELA_Human1.04308285
113CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03998617
114VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03085234
115RUNX2_22187159_ChIP-Seq_PCA_Human1.02565108
116AHR_22903824_ChIP-Seq_MCF-7_Human1.02538952
117* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01771651
118* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00384950
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00256613
120RUNX1_26923725_Chip-Seq_HPCs_Mouse1.00241659
121KDM2B_26808549_Chip-Seq_DND41_Human1.00120561
122CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.00007895
123* TCF4_23295773_ChIP-Seq_U87_Human0.98952972
124* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98516098
125P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98134703
126CREB1_26743006_Chip-Seq_LNCaP_Human0.97952491
127TP53_20018659_ChIP-ChIP_R1E_Mouse0.97227131
128AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96539940
129AR_19668381_ChIP-Seq_PC3_Human0.96234821
130PRDM14_20953172_ChIP-Seq_ESCs_Human0.95406612
131NANOG_18555785_Chip-Seq_ESCs_Mouse0.95395750
132CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94478475
133STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94395172
134TET1_21490601_ChIP-Seq_MESCs_Mouse0.94158209
135LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93730408
136TP53_18474530_ChIP-ChIP_U2OS_Human0.92989488
137NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92716073
138SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.92104734
139YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91046042
140KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.90774117
141SOX3_22085726_ChIP-Seq_NPCs_Mouse0.90665277
142EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90590269
143CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90354948
144EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89274852
145CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87926008
146* SMAD3_21741376_ChIP-Seq_ESCs_Human0.86833121
147* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.85234832
148MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.84606390
149KDM2B_26808549_Chip-Seq_JURKAT_Human0.84183702
150NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.81629967
151* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.80583647
152ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80350078
153GATA1_26923725_Chip-Seq_HPCs_Mouse0.80070313

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.38662818
2MP0005423_abnormal_somatic_nervous4.12508889
3MP0004859_abnormal_synaptic_plasticity3.92364914
4MP0003635_abnormal_synaptic_transmissio3.10236713
5MP0004270_analgesia3.00393454
6MP0000778_abnormal_nervous_system2.77194233
7MP0009745_abnormal_behavioral_response2.58395823
8MP0002822_catalepsy2.57794233
9MP0001486_abnormal_startle_reflex2.52914439
10MP0002063_abnormal_learning/memory/cond2.48514264
11MP0001968_abnormal_touch/_nociception2.40188218
12MP0002064_seizures2.39678466
13MP0002572_abnormal_emotion/affect_behav2.23041238
14MP0002272_abnormal_nervous_system2.20750801
15MP0002734_abnormal_mechanical_nocicepti2.19952497
16MP0003123_paternal_imprinting2.16457381
17MP0009046_muscle_twitch2.15974932
18MP0000579_abnormal_nail_morphology2.15917547
19MP0005248_abnormal_Harderian_gland2.10676401
20MP0004742_abnormal_vestibular_system2.06178610
21MP0006276_abnormal_autonomic_nervous2.04309304
22MP0002184_abnormal_innervation2.00133608
23MP0005645_abnormal_hypothalamus_physiol1.94991045
24MP0001529_abnormal_vocalization1.89804008
25MP0002067_abnormal_sensory_capabilities1.83899518
26MP0002736_abnormal_nociception_after1.83700357
27MP0005409_darkened_coat_color1.83524039
28MP0000920_abnormal_myelination1.80310601
29MP0003942_abnormal_urinary_system1.80262589
30MP0002735_abnormal_chemical_nociception1.79829951
31MP0002733_abnormal_thermal_nociception1.77104476
32MP0002557_abnormal_social/conspecific_i1.76935594
33MP0001440_abnormal_grooming_behavior1.73253540
34MP0000955_abnormal_spinal_cord1.72562341
35MP0003136_yellow_coat_color1.71692371
36MP0001970_abnormal_pain_threshold1.69739278
37MP0004885_abnormal_endolymph1.67172005
38MP0002653_abnormal_ependyma_morphology1.62929532
39MP0004142_abnormal_muscle_tone1.62548089
40MP0005646_abnormal_pituitary_gland1.61348385
41MP0002102_abnormal_ear_morphology1.60979822
42MP0003705_abnormal_hypodermis_morpholog1.60522376
43MP0001188_hyperpigmentation1.59463059
44MP0002882_abnormal_neuron_morphology1.58203655
45MP0001905_abnormal_dopamine_level1.53624049
46MP0004924_abnormal_behavior1.49508286
47MP0005386_behavior/neurological_phenoty1.49508286
48MP0000631_abnormal_neuroendocrine_gland1.44476391
49MP0004264_abnormal_extraembryonic_tissu1.43443832
50MP0002098_abnormal_vibrissa_morphology1.42813231
51MP0005076_abnormal_cell_differentiation1.42319503
52MP0005171_absent_coat_pigmentation1.39924750
53MP0004858_abnormal_nervous_system1.38011720
54MP0000383_abnormal_hair_follicle1.36049728
55MP0004811_abnormal_neuron_physiology1.35135432
56MP0006292_abnormal_olfactory_placode1.34766816
57MP0008569_lethality_at_weaning1.34623471
58MP0005551_abnormal_eye_electrophysiolog1.34273088
59MP0003634_abnormal_glial_cell1.34244523
60MP0010030_abnormal_orbit_morphology1.33673769
61MP0002066_abnormal_motor_capabilities/c1.32949666
62MP0001984_abnormal_olfaction1.31824317
63MP0002152_abnormal_brain_morphology1.29757377
64MP0003938_abnormal_ear_development1.29437937
65MP0003121_genomic_imprinting1.27684130
66MP0002752_abnormal_somatic_nervous1.26767269
67MP0001501_abnormal_sleep_pattern1.25690485
68MP0003283_abnormal_digestive_organ1.22203039
69MP0009780_abnormal_chondrocyte_physiolo1.20894959
70MP0000026_abnormal_inner_ear1.16180509
71MP0000566_synostosis1.16149889
72MP0001346_abnormal_lacrimal_gland1.15935498
73MP0001963_abnormal_hearing_physiology1.12701204
74MP0006072_abnormal_retinal_apoptosis1.09428594
75MP0009053_abnormal_anal_canal1.08899750
76MP0003329_amyloid_beta_deposits1.08723268
77MP0001502_abnormal_circadian_rhythm1.08546395
78MP0002229_neurodegeneration1.08513641
79MP0009250_abnormal_appendicular_skeleto1.06859886
80MP0003861_abnormal_nervous_system1.03584796
81MP0000049_abnormal_middle_ear1.02636586
82MP0010678_abnormal_skin_adnexa1.01413431
83MP0003690_abnormal_glial_cell1.01197762
84MP0003122_maternal_imprinting0.99098257
85MP0003385_abnormal_body_wall0.98954221
86MP0001485_abnormal_pinna_reflex0.96130726
87MP0002697_abnormal_eye_size0.95799293
88MP0003115_abnormal_respiratory_system0.95731875
89MP0002249_abnormal_larynx_morphology0.95330368
90MP0003787_abnormal_imprinting0.93414430
91MP0009384_cardiac_valve_regurgitation0.93400952
92MP0001299_abnormal_eye_distance/0.91942974
93MP0002751_abnormal_autonomic_nervous0.91885978
94MP0003631_nervous_system_phenotype0.91442100
95MP0000427_abnormal_hair_cycle0.91328729
96MP0000534_abnormal_ureter_morphology0.90510644
97MP0005499_abnormal_olfactory_system0.90259941
98MP0005394_taste/olfaction_phenotype0.90259941
99MP0001340_abnormal_eyelid_morphology0.90061825
100MP0003632_abnormal_nervous_system0.90029557
101MP0003633_abnormal_nervous_system0.89680403
102MP0004133_heterotaxia0.89445661
103MP0000538_abnormal_urinary_bladder0.88525204
104MP0004145_abnormal_muscle_electrophysio0.88174651
105MP0002638_abnormal_pupillary_reflex0.87925589
106MP0000377_abnormal_hair_follicle0.86648834
107MP0003941_abnormal_skin_development0.86386349
108MP0000462_abnormal_digestive_system0.86300491
109MP0009672_abnormal_birth_weight0.86039391
110MP0003937_abnormal_limbs/digits/tail_de0.84662284
111MP0002092_abnormal_eye_morphology0.84231900
112MP0000537_abnormal_urethra_morphology0.83390304
113MP0004134_abnormal_chest_morphology0.83290613
114MP0005195_abnormal_posterior_eye0.82923303
115MP0010234_abnormal_vibrissa_follicle0.82728927
116MP0005253_abnormal_eye_physiology0.82651230
117MP0000428_abnormal_craniofacial_morphol0.80822431
118MP0002233_abnormal_nose_morphology0.80031006
119MP0002932_abnormal_joint_morphology0.78491410
120MP0001177_atelectasis0.77235893
121MP0001943_abnormal_respiration0.76497483
122MP0002796_impaired_skin_barrier0.75704242
123MP0001849_ear_inflammation0.75363380
124MP0008789_abnormal_olfactory_epithelium0.74589650
125MP0002069_abnormal_eating/drinking_beha0.74129290
126MP0003137_abnormal_impulse_conducting0.73113028
127MP0003755_abnormal_palate_morphology0.69950662
128MP0004085_abnormal_heartbeat0.68969399
129MP0002116_abnormal_craniofacial_bone0.67447246
130MP0005167_abnormal_blood-brain_barrier0.65550802
131MP0002081_perinatal_lethality0.63420239
132MP0002909_abnormal_adrenal_gland0.60905549

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.62467232
2Focal motor seizures (HP:0011153)4.47343727
3Hyperacusis (HP:0010780)3.77618473
4Neurofibrillary tangles (HP:0002185)3.69899782
5Supranuclear gaze palsy (HP:0000605)3.67720924
6Abnormality of the corticospinal tract (HP:0002492)3.60133196
7Focal seizures (HP:0007359)3.53669688
8Broad-based gait (HP:0002136)3.53276392
9Degeneration of the lateral corticospinal tracts (HP:0002314)3.50719294
10Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.50719294
11Hyperventilation (HP:0002883)3.46189987
12Asymmetry of the thorax (HP:0001555)3.34351019
13Excessive salivation (HP:0003781)3.07824679
14Drooling (HP:0002307)3.07824679
15Ankle clonus (HP:0011448)3.05484255
16Epileptic encephalopathy (HP:0200134)3.01361089
17Limb dystonia (HP:0002451)2.93976429
18Neuroendocrine neoplasm (HP:0100634)2.91749544
19Hemiparesis (HP:0001269)2.89223941
20Cerebral inclusion bodies (HP:0100314)2.87149292
21Mutism (HP:0002300)2.84052733
22Progressive inability to walk (HP:0002505)2.83290459
23Pheochromocytoma (HP:0002666)2.82440039
24Akinesia (HP:0002304)2.81585687
25Absent speech (HP:0001344)2.81385691
26Overriding aorta (HP:0002623)2.79088118
27Progressive cerebellar ataxia (HP:0002073)2.77895776
28Spastic gait (HP:0002064)2.74773601
29J-shaped sella turcica (HP:0002680)2.74659674
30Absent frontal sinuses (HP:0002688)2.73470344
31Alacrima (HP:0000522)2.73066795
32Peripheral hypomyelination (HP:0007182)2.72962893
33Retinal dysplasia (HP:0007973)2.71169289
34Elfin facies (HP:0004428)2.69611059
35Concave nail (HP:0001598)2.67826741
36Enlarged penis (HP:0000040)2.66254153
37Macroorchidism (HP:0000053)2.63177696
38Hyperparathyroidism (HP:0000843)2.63100101
39Visual hallucinations (HP:0002367)2.58730575
40Synostosis involving the elbow (HP:0003938)2.56787041
41Humeroradial synostosis (HP:0003041)2.56787041
42Aplasia involving bones of the extremities (HP:0009825)2.56338976
43Aplasia involving bones of the upper limbs (HP:0009823)2.56338976
44Aplasia of the phalanges of the hand (HP:0009802)2.56338976
45Buphthalmos (HP:0000557)2.54032912
46Megalencephaly (HP:0001355)2.52092788
47Renovascular hypertension (HP:0100817)2.50388327
48Hypercortisolism (HP:0001578)2.49259284
49Absent septum pellucidum (HP:0001331)2.48396654
50Renal dysplasia (HP:0000110)2.45308688
51Decreased lacrimation (HP:0000633)2.44390404
52Insomnia (HP:0100785)2.44111576
53Generalized tonic-clonic seizures (HP:0002069)2.37232102
54Insidious onset (HP:0003587)2.35881740
55Termporal pattern (HP:0011008)2.35881740
56Microglossia (HP:0000171)2.35616117
57Septo-optic dysplasia (HP:0100842)2.33224610
58Action tremor (HP:0002345)2.30702544
59Septate vagina (HP:0001153)2.29001934
60Lower limb muscle weakness (HP:0007340)2.27168224
61Fetal akinesia sequence (HP:0001989)2.27147343
62Hypoplastic pelvis (HP:0008839)2.25235613
63Obstructive sleep apnea (HP:0002870)2.25055169
64Urinary urgency (HP:0000012)2.24788740
65Abnormality of salivation (HP:0100755)2.24182949
66Urinary bladder sphincter dysfunction (HP:0002839)2.22668397
67Thickened helices (HP:0000391)2.21638555
68Germ cell neoplasia (HP:0100728)2.20616875
69Dysmetria (HP:0001310)2.19987356
70Abnormality of the septum pellucidum (HP:0007375)2.19844777
71Abnormality of the diencephalon (HP:0010662)2.16930073
72Polyphagia (HP:0002591)2.16441837
73Amblyopia (HP:0000646)2.16181204
74Oligodactyly (HP:0012165)2.13573164
75Turricephaly (HP:0000262)2.13460920
76Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.13195154
77Impaired vibration sensation in the lower limbs (HP:0002166)2.12525887
78Patellar dislocation (HP:0002999)2.11594399
79Poor eye contact (HP:0000817)2.11385905
80Esotropia (HP:0000565)2.11204624
81Febrile seizures (HP:0002373)2.08188542
82Aplasia/Hypoplasia of the brainstem (HP:0007362)2.08095970
83Hypoplasia of the brainstem (HP:0002365)2.08095970
84Blue irides (HP:0000635)2.07718189
85Dysdiadochokinesis (HP:0002075)2.07536106
86Atonic seizures (HP:0010819)2.07128961
87Anxiety (HP:0000739)2.06915589
88Exostoses (HP:0100777)2.06809708
89Congenital glaucoma (HP:0001087)2.05306755
90Intellectual disability, moderate (HP:0002342)2.04335109
91Abnormality of the aortic arch (HP:0012303)2.04193732
92Agitation (HP:0000713)2.04068247
93Pachygyria (HP:0001302)2.02673628
94Abnormal eating behavior (HP:0100738)2.01131992
95Dialeptic seizures (HP:0011146)2.00252971
96Absence seizures (HP:0002121)1.98233025
97Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.98212815
98Renal duplication (HP:0000075)1.97392077
99Sleep apnea (HP:0010535)1.97233355
100Bicornuate uterus (HP:0000813)1.97096889
101Hypercalcemia (HP:0003072)1.96635276
102Sensory axonal neuropathy (HP:0003390)1.96492226
103Bronchomalacia (HP:0002780)1.95594014
104Cutaneous finger syndactyly (HP:0010554)1.94657943
105Intention tremor (HP:0002080)1.94557106
106Inability to walk (HP:0002540)1.94336009
107Abnormality of the parathyroid morphology (HP:0011766)1.92824019
108Deformed sella turcica (HP:0002681)1.91972317
109Shawl scrotum (HP:0000049)1.91308526
110Megalocornea (HP:0000485)1.90550012
111Absent/shortened dynein arms (HP:0200106)1.89740609
112Dynein arm defect of respiratory motile cilia (HP:0012255)1.89740609
113Precocious puberty (HP:0000826)1.88593149
114Gastroesophageal reflux (HP:0002020)1.87956516
115Chin dimple (HP:0010751)1.87816692
116Truncal ataxia (HP:0002078)1.87708414
117Increased nuchal translucency (HP:0010880)1.87295632
118Neoplasm of the peripheral nervous system (HP:0100007)1.87190160
119Broad face (HP:0000283)1.87097204
120Scanning speech (HP:0002168)1.87085820
121Lissencephaly (HP:0001339)1.87074722
122Gaze-evoked nystagmus (HP:0000640)1.86545058
123Curly hair (HP:0002212)1.86224706
124Failure to thrive in infancy (HP:0001531)1.84954914
125Pointed chin (HP:0000307)1.84716877
126Morphological abnormality of the pyramidal tract (HP:0002062)1.84390125
127Specific learning disability (HP:0001328)1.83920880
128Split foot (HP:0001839)1.83767224
129Partial agenesis of the corpus callosum (HP:0001338)1.83245893
130Micronodular cirrhosis (HP:0001413)1.82521371
131Bowel diverticulosis (HP:0005222)1.81764355
132Torticollis (HP:0000473)1.81313014
133Abnormality of calcium-phosphate metabolism (HP:0100530)1.80775396
134Bowel incontinence (HP:0002607)1.79800067
135Abnormality of the 4th metacarpal (HP:0010012)1.79358346
136Arnold-Chiari malformation (HP:0002308)1.78329584
137Abnormality of the frontal sinuses (HP:0002687)1.77752370
138Ulnar claw (HP:0001178)1.77403842
139Aqueductal stenosis (HP:0002410)1.77395803
140Impaired social interactions (HP:0000735)1.76951309
141Abnormal social behavior (HP:0012433)1.76951309
142Hypoplasia of the iris (HP:0007676)1.75753186
143Myelomeningocele (HP:0002475)1.75374791
144Cutaneous syndactyly (HP:0012725)1.74961592
145Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.74841302
146Short 4th metacarpal (HP:0010044)1.74841302
147Sporadic (HP:0003745)1.74729582
148Hyperthyroidism (HP:0000836)1.74419281
149Gait imbalance (HP:0002141)1.73981751
150Optic nerve hypoplasia (HP:0000609)1.73557108
151Midline defect of the nose (HP:0004122)1.73100977
152Spina bifida occulta (HP:0003298)1.71424541
153Heterochromia iridis (HP:0001100)1.71233565
154Diplopia (HP:0000651)1.71098877
155Abnormality of binocular vision (HP:0011514)1.71098877
156Morphological abnormality of the middle ear (HP:0008609)1.71023597
157Neoplasm of the thyroid gland (HP:0100031)1.70896149
158Lower limb asymmetry (HP:0100559)1.70522656
159EEG with generalized epileptiform discharges (HP:0011198)1.70445427
160Decreased central vision (HP:0007663)1.70345229
161High anterior hairline (HP:0009890)1.70225552
162Lymphangioma (HP:0100764)1.69219013
163Exotropia (HP:0000577)1.68601846
164Epileptiform EEG discharges (HP:0011182)1.67851917
165Neonatal hypoglycemia (HP:0001998)1.65770766
166Obsessive-compulsive behavior (HP:0000722)1.64812986
167Broad distal phalanx of finger (HP:0009836)1.62893564
168Abnormality of the sella turcica (HP:0002679)1.61710393
169Cortical dysplasia (HP:0002539)1.61044405
170Ulnar bowing (HP:0003031)1.60892664
171Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.60201540
172Long toe (HP:0010511)1.60117033
173Vertebral arch anomaly (HP:0008438)1.58797842
174Flat cornea (HP:0007720)1.58749377
175Abnormality of the distal phalanx of the thumb (HP:0009617)1.58006031

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.33646991
2MARK14.95928005
3CASK4.90010034
4SIK13.35360662
5NTRK33.10445015
6PKN23.08506866
7EPHA42.86133257
8TNIK2.44429340
9NTRK22.33894417
10STK392.30905155
11PNCK2.22579823
12MAPK132.15483221
13MAP3K92.04981485
14RPS6KB21.93459542
15SCYL21.92742991
16MAP3K41.89575132
17PKN11.88832196
18TESK11.85469009
19PIK3CA1.84990630
20PHKG11.82066492
21PHKG21.82066492
22DYRK21.77980434
23INSRR1.77040248
24EPHA21.70331450
25UHMK11.69220741
26RIPK11.67842662
27PAK61.67458980
28MAP2K71.60439831
29OXSR11.53697071
30MAP2K21.52928050
31SIK21.49136767
32MINK11.47440677
33RET1.38463316
34CDK51.32616163
35SMG11.30656282
36NTRK11.23628832
37MAP3K101.23017753
38DAPK21.19754697
39KSR11.16494663
40GRK11.15686832
41CSNK1G21.13787753
42MAPKAPK31.08705863
43MARK21.08303977
44WNK41.07999811
45GRK71.07711669
46FES1.07062136
47TYRO31.04171561
48CSNK1G31.01793591
49BMPR1B1.01419050
50RPS6KA21.00559425
51MTOR0.99991317
52PRPF4B0.98762139
53CSNK1A1L0.98096279
54FGFR20.97572699
55CAMK1G0.96244316
56BCR0.94022184
57PAK30.93982690
58EEF2K0.93253359
59PDGFRA0.91643826
60FGR0.89839826
61CAMK2B0.89635791
62NEK60.88721628
63CAMK2A0.88583377
64PTK20.88482303
65DYRK1A0.87344199
66SIK30.86022720
67MAP2K40.83797906
68IRAK20.82354018
69LIMK10.82280972
70WNK30.82060514
71PTK60.80244496
72SGK4940.78821331
73SGK2230.78821331
74PRKCG0.77753858
75ILK0.76842276
76MUSK0.76712764
77MKNK20.76258430
78MAP3K120.76239923
79CDK150.76138662
80CSNK1G10.76078022
81STK110.76021901
82CDK180.75584721
83ERBB30.75185194
84CDK140.75021331
85ROCK20.74310243
86PRKCI0.73933142
87CDK190.73604928
88MAPKAPK50.73018136
89EPHB20.72272834
90SGK20.70787313
91ADRBK20.70309651
92CDK11A0.68575895
93RPS6KB10.68423530
94FGFR40.67282241
95MAPK150.65501085
96WNK10.65251079
97PLK20.64436575
98PRKCE0.64001513
99MAP2K10.63973612
100TRIM280.62391913
101PRKCZ0.61260542
102EPHA30.61228014
103TAOK10.60361658
104SGK30.59979814
105GRK50.58379817
106PRKD30.55454311
107FYN0.54352754
108DYRK1B0.54014425
109PDGFRB0.52726308
110KSR20.52161792
111SGK10.51460546
112DDR20.50639791
113CAMK2D0.49845099
114ADRBK10.48824276
115ERBB20.48296741
116PRKD20.48035879
117CAMK10.45578614
118CLK10.45426872
119ERBB40.45370814
120PRKG10.45322721
121ALK0.44993722
122MKNK10.44926549
123CSNK1D0.44459782
124EPHB10.44440431
125CAMKK10.44201920
126CHUK0.44007075
127ICK0.43488338
128ROCK10.42834452
129CDK120.42756171
130PRKCH0.41765408
131CAMK2G0.41702792
132MAPK80.41234574
133LATS20.40918084
134YES10.40706537
135PRKD10.40516120
136EIF2AK10.38349820
137LRRK20.37920608
138MAPK100.37464186
139EIF2AK20.36713018
140DMPK0.35974747
141TESK20.34425364
142MAPK90.34258590

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.41714503
2Glutamatergic synapse_Homo sapiens_hsa047242.68285229
3GABAergic synapse_Homo sapiens_hsa047272.61808996
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.55176686
5Morphine addiction_Homo sapiens_hsa050322.48860903
6Axon guidance_Homo sapiens_hsa043602.40458565
7Circadian entrainment_Homo sapiens_hsa047132.28158060
8Olfactory transduction_Homo sapiens_hsa047402.26363936
9Serotonergic synapse_Homo sapiens_hsa047262.18801130
10Cocaine addiction_Homo sapiens_hsa050302.10642396
11Dopaminergic synapse_Homo sapiens_hsa047282.05382406
12Synaptic vesicle cycle_Homo sapiens_hsa047211.96015910
13Phototransduction_Homo sapiens_hsa047441.92686062
14Amphetamine addiction_Homo sapiens_hsa050311.92634212
15Long-term depression_Homo sapiens_hsa047301.91789776
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88693983
17Cholinergic synapse_Homo sapiens_hsa047251.82887846
18Taste transduction_Homo sapiens_hsa047421.81157506
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.74781574
20Thyroid hormone signaling pathway_Homo sapiens_hsa049191.65975632
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.65832103
22Salivary secretion_Homo sapiens_hsa049701.64017337
23Notch signaling pathway_Homo sapiens_hsa043301.62987418
24Long-term potentiation_Homo sapiens_hsa047201.62986122
25Thyroid cancer_Homo sapiens_hsa052161.61691336
26Gap junction_Homo sapiens_hsa045401.60796028
27Renin secretion_Homo sapiens_hsa049241.56082283
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.52831295
29Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.50682241
30Insulin secretion_Homo sapiens_hsa049111.44560877
31Central carbon metabolism in cancer_Homo sapiens_hsa052301.42301969
32Gastric acid secretion_Homo sapiens_hsa049711.41975339
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39890230
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33555302
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.31675574
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29981174
37* Oxytocin signaling pathway_Homo sapiens_hsa049211.29201392
38Calcium signaling pathway_Homo sapiens_hsa040201.28531189
39mTOR signaling pathway_Homo sapiens_hsa041501.28464759
40* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.28448379
41AMPK signaling pathway_Homo sapiens_hsa041521.28062467
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.27313086
43Non-small cell lung cancer_Homo sapiens_hsa052231.24251987
44Ether lipid metabolism_Homo sapiens_hsa005651.20329604
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.19605878
46GnRH signaling pathway_Homo sapiens_hsa049121.18868103
47Longevity regulating pathway - mammal_Homo sapiens_hsa042111.18511276
48ErbB signaling pathway_Homo sapiens_hsa040121.16227259
49Chronic myeloid leukemia_Homo sapiens_hsa052201.12723263
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.08467873
51Insulin signaling pathway_Homo sapiens_hsa049101.08425851
52Melanogenesis_Homo sapiens_hsa049161.07899902
53cAMP signaling pathway_Homo sapiens_hsa040241.07731040
54Prolactin signaling pathway_Homo sapiens_hsa049171.07413155
55Dorso-ventral axis formation_Homo sapiens_hsa043201.06576649
56* Cardiac muscle contraction_Homo sapiens_hsa042601.02634037
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02024328
58Vascular smooth muscle contraction_Homo sapiens_hsa042701.01216106
59Glioma_Homo sapiens_hsa052141.00928960
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.97993746
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97440949
62Ras signaling pathway_Homo sapiens_hsa040140.96907733
63Estrogen signaling pathway_Homo sapiens_hsa049150.95224041
64Renal cell carcinoma_Homo sapiens_hsa052110.94886414
65Hedgehog signaling pathway_Homo sapiens_hsa043400.94437669
66Choline metabolism in cancer_Homo sapiens_hsa052310.90492085
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90482068
68Alcoholism_Homo sapiens_hsa050340.87383915
69Steroid biosynthesis_Homo sapiens_hsa001000.86495931
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85436099
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85303380
72Sphingolipid metabolism_Homo sapiens_hsa006000.83820194
73Adherens junction_Homo sapiens_hsa045200.83328631
74Type II diabetes mellitus_Homo sapiens_hsa049300.82090548
75Butanoate metabolism_Homo sapiens_hsa006500.81466647
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79387954
77Wnt signaling pathway_Homo sapiens_hsa043100.79066502
78Prostate cancer_Homo sapiens_hsa052150.78030184
79MicroRNAs in cancer_Homo sapiens_hsa052060.77975233
80Acute myeloid leukemia_Homo sapiens_hsa052210.76483880
81Alzheimers disease_Homo sapiens_hsa050100.75871829
82Oxidative phosphorylation_Homo sapiens_hsa001900.74829238
83Inositol phosphate metabolism_Homo sapiens_hsa005620.74416997
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74025491
85* MAPK signaling pathway_Homo sapiens_hsa040100.73401808
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.73303311
87Fatty acid elongation_Homo sapiens_hsa000620.73120250
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71586534
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71486535
90Collecting duct acid secretion_Homo sapiens_hsa049660.71237517
91Pancreatic cancer_Homo sapiens_hsa052120.70987038
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70294652
93Rap1 signaling pathway_Homo sapiens_hsa040150.69250269
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68231742
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68135208
96Vitamin B6 metabolism_Homo sapiens_hsa007500.66655894
97mRNA surveillance pathway_Homo sapiens_hsa030150.66633413
98Basal cell carcinoma_Homo sapiens_hsa052170.66263837
99Bladder cancer_Homo sapiens_hsa052190.65833652
100Tight junction_Homo sapiens_hsa045300.65468380
101Parkinsons disease_Homo sapiens_hsa050120.64932784
102Bile secretion_Homo sapiens_hsa049760.63327599
103Ovarian steroidogenesis_Homo sapiens_hsa049130.61674831
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60403954
105Melanoma_Homo sapiens_hsa052180.60220752
106Prion diseases_Homo sapiens_hsa050200.60083107
107Vibrio cholerae infection_Homo sapiens_hsa051100.57696549
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55898666
109Proteoglycans in cancer_Homo sapiens_hsa052050.55171736
110Lysine degradation_Homo sapiens_hsa003100.54879645
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54714347
112* Dilated cardiomyopathy_Homo sapiens_hsa054140.52534644
113Pancreatic secretion_Homo sapiens_hsa049720.52009758
114* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51515448
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50455465
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50300610
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49199367
118Focal adhesion_Homo sapiens_hsa045100.48423108
119TGF-beta signaling pathway_Homo sapiens_hsa043500.48317870
120Endocytosis_Homo sapiens_hsa041440.48235459
121Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45398050
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43352145
123Hippo signaling pathway_Homo sapiens_hsa043900.42649512
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42463835
125Huntingtons disease_Homo sapiens_hsa050160.40325693
126Thyroid hormone synthesis_Homo sapiens_hsa049180.38549150
127Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.36558922
128Oocyte meiosis_Homo sapiens_hsa041140.33753174
129Endometrial cancer_Homo sapiens_hsa052130.31519371
130Colorectal cancer_Homo sapiens_hsa052100.29568005
131Chemokine signaling pathway_Homo sapiens_hsa040620.28079012
132Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.25650639
133VEGF signaling pathway_Homo sapiens_hsa043700.24382771
134* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24097942

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