CABS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.73714365
2motile cilium assembly (GO:0044458)9.04855749
3response to pheromone (GO:0019236)8.88612237
4cilium movement (GO:0003341)8.84895521
5regulation of cilium movement (GO:0003352)8.49541702
6single fertilization (GO:0007338)7.93878641
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.92953916
8sperm capacitation (GO:0048240)7.52170101
9protein targeting to Golgi (GO:0000042)7.51416461
10establishment of protein localization to Golgi (GO:0072600)7.21317939
11rRNA methylation (GO:0031167)7.14263461
12retrograde transport, vesicle recycling within Golgi (GO:0000301)7.01676542
13male meiosis (GO:0007140)7.01188990
14synaptonemal complex organization (GO:0070193)6.93013960
15synaptonemal complex assembly (GO:0007130)6.78597130
16fertilization (GO:0009566)6.56864458
17negative regulation of inclusion body assembly (GO:0090084)6.54050005
18piRNA metabolic process (GO:0034587)6.53328763
19* spermatogenesis (GO:0007283)6.30404154
20* male gamete generation (GO:0048232)6.28239693
21microtubule depolymerization (GO:0007019)6.14815574
22phosphatidylethanolamine biosynthetic process (GO:0006646)6.13110630
23organic cation transport (GO:0015695)6.07889432
24spermatid nucleus differentiation (GO:0007289)6.04874687
25rRNA modification (GO:0000154)6.00919085
26* gamete generation (GO:0007276)5.77430543
27phosphatidylethanolamine metabolic process (GO:0046337)5.66905274
28calcium ion-dependent exocytosis (GO:0017156)5.51163464
29regulation of inclusion body assembly (GO:0090083)5.50549596
30protein localization to Golgi apparatus (GO:0034067)5.44996208
31ventricular system development (GO:0021591)5.41032965
32sexual reproduction (GO:0019953)5.39445069
33germ cell development (GO:0007281)5.37717240
34cellular process involved in reproduction in multicellular organism (GO:0022412)5.33265108
35glycerol ether metabolic process (GO:0006662)5.17487532
36regulation of centriole replication (GO:0046599)5.12765097
37positive regulation of Rab GTPase activity (GO:0032851)5.08554146
38regulation of Rab GTPase activity (GO:0032313)5.08554146
39cellular ketone body metabolic process (GO:0046950)5.04950349
40regulation of microtubule-based movement (GO:0060632)5.02395594
41cell recognition (GO:0008037)5.00385875
42single strand break repair (GO:0000012)4.82787044
43ether metabolic process (GO:0018904)4.78076418
44RNA destabilization (GO:0050779)4.74881542
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.62914669
46male meiosis I (GO:0007141)4.61141778
47chromosome organization involved in meiosis (GO:0070192)4.59789511
48* multicellular organismal reproductive process (GO:0048609)4.57123575
49regulation of transcription involved in cell fate commitment (GO:0060850)4.46298156
50ketone body metabolic process (GO:1902224)4.44953176
51microtubule severing (GO:0051013)4.43412101
52chromosome condensation (GO:0030261)4.26323150
53seminiferous tubule development (GO:0072520)4.21603183
54DNA methylation involved in gamete generation (GO:0043046)4.20358459
55glomerular visceral epithelial cell development (GO:0072015)4.12800129
56meiotic nuclear division (GO:0007126)4.12238793
57left/right pattern formation (GO:0060972)4.10971200
58DNA packaging (GO:0006323)4.05104529
59musculoskeletal movement (GO:0050881)3.97954855
60multicellular organismal movement (GO:0050879)3.97954855
61monoubiquitinated protein deubiquitination (GO:0035520)3.97121666
62glomerular epithelial cell development (GO:0072310)3.91804665
63genitalia morphogenesis (GO:0035112)3.91504881
64protein K11-linked deubiquitination (GO:0035871)3.80590552
65coenzyme catabolic process (GO:0009109)3.76869400
66negative regulation of Rho protein signal transduction (GO:0035024)3.76577101
67multicellular organismal development (GO:0007275)3.73120399
68microtubule nucleation (GO:0007020)3.72029081
69meiosis I (GO:0007127)3.64671002
70chaperone-mediated protein complex assembly (GO:0051131)3.60135233
71glycolytic process (GO:0006096)3.42990489
72protein polyglutamylation (GO:0018095)3.32185685
73protein refolding (GO:0042026)3.31505533
74protein depolymerization (GO:0051261)3.26366341
75membrane protein intracellular domain proteolysis (GO:0031293)3.26181275
76cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.23955666
77nucleus organization (GO:0006997)3.18055178
78microtubule polymerization or depolymerization (GO:0031109)3.17419255
79meiotic cell cycle (GO:0051321)3.15572135
80cerebral cortex neuron differentiation (GO:0021895)3.14437795
81sequestering of actin monomers (GO:0042989)3.11977891
82response to acidic pH (GO:0010447)3.10425259
83regulation of interleukin-13 production (GO:0032656)3.09985813
84histone H3-K9 demethylation (GO:0033169)3.09775349
85protein localization to cilium (GO:0061512)3.09000988
86protein-DNA complex disassembly (GO:0032986)3.08844356
87nucleosome disassembly (GO:0006337)3.08844356
88nucleoside diphosphate phosphorylation (GO:0006165)3.07118744
89cellular response to pH (GO:0071467)3.06380004
90regulation of somitogenesis (GO:0014807)3.04672901
91polyol catabolic process (GO:0046174)2.97720561
92lactate metabolic process (GO:0006089)2.97046986
93cilium organization (GO:0044782)2.96645257
94negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.95443718
95peptidyl-threonine dephosphorylation (GO:0035970)2.94186460
96regulation of T-helper 2 cell differentiation (GO:0045628)2.93351446
97alditol metabolic process (GO:0019400)2.92784364
98GTP biosynthetic process (GO:0006183)2.92478753
99homeostasis of number of cells within a tissue (GO:0048873)2.92110174
100negative regulation of gene expression, epigenetic (GO:0045814)2.90280649
101centriole assembly (GO:0098534)2.90109575
102microtubule-based movement (GO:0007018)2.89909671
103mesenchymal cell differentiation involved in renal system development (GO:2001012)2.88889021
104mesenchymal cell differentiation involved in kidney development (GO:0072161)2.88889021
105DNA conformation change (GO:0071103)2.87287033
106cilium assembly (GO:0042384)2.85364786
107intra-Golgi vesicle-mediated transport (GO:0006891)2.85310653
108carnitine transport (GO:0015879)2.85211262
109amino-acid betaine transport (GO:0015838)2.85211262
110cell differentiation involved in metanephros development (GO:0072202)2.80089023
111regulation of phosphoprotein phosphatase activity (GO:0043666)2.77011025
112cranial nerve morphogenesis (GO:0021602)2.74960680
113Golgi to endosome transport (GO:0006895)2.74196451
114cellular component assembly involved in morphogenesis (GO:0010927)2.73445115
115regulation of spindle checkpoint (GO:0090231)2.72131187
116carnitine transmembrane transport (GO:1902603)2.67197070
117mitotic sister chromatid cohesion (GO:0007064)2.66293855
118meiotic cell cycle process (GO:1903046)2.65717025
119chromatin silencing (GO:0006342)2.64425352
120intraciliary transport (GO:0042073)2.63442384
121negative regulation of organelle assembly (GO:1902116)2.63051979
122UTP biosynthetic process (GO:0006228)2.63007199
123axoneme assembly (GO:0035082)2.60707613
124positive regulation of macrophage activation (GO:0043032)2.60515608
125polyamine biosynthetic process (GO:0006596)2.58678403
126synapsis (GO:0007129)2.55553215
127cilium morphogenesis (GO:0060271)2.55043728
128centriole replication (GO:0007099)2.53786493
129nuclear pore complex assembly (GO:0051292)2.49675373
130interferon-gamma secretion (GO:0072643)2.48957902
131positive regulation of glycolytic process (GO:0045821)2.47155725
132glycerol metabolic process (GO:0006071)2.46899009
133macroautophagy (GO:0016236)2.43530527
134sperm motility (GO:0030317)14.5078897
135fusion of sperm to egg plasma membrane (GO:0007342)14.3628557
136cell wall macromolecule metabolic process (GO:0044036)13.3840340
137cell wall macromolecule catabolic process (GO:0016998)13.3840340
138acrosome reaction (GO:0007340)11.6481884
139multicellular organism reproduction (GO:0032504)11.5375312
140sperm-egg recognition (GO:0035036)11.4947894
141acrosome assembly (GO:0001675)11.1347175
142plasma membrane fusion (GO:0045026)10.9595097
143epithelial cilium movement (GO:0003351)10.7742867
144cilium or flagellum-dependent cell motility (GO:0001539)10.4676143
145binding of sperm to zona pellucida (GO:0007339)10.4653865
146cell-cell recognition (GO:0009988)10.3056378
147reproduction (GO:0000003)10.1724022
148axonemal dynein complex assembly (GO:0070286)10.1170105

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.74818331
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.28109274
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.92551917
4EZH2_22144423_ChIP-Seq_EOC_Human3.82808946
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.76695353
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.71001246
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.71352244
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.68110271
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.40547521
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.33730383
11VDR_22108803_ChIP-Seq_LS180_Human2.28399506
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.26608363
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.15553306
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.03587622
15CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.02734030
16VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.01447639
17EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.94756979
18ELF1_20517297_ChIP-Seq_JURKAT_Human1.94181584
19KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.93535695
20ERA_21632823_ChIP-Seq_H3396_Human1.91087674
21RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.89910015
22RAC3_21632823_ChIP-Seq_H3396_Human1.88960998
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.86307743
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.84243168
25DROSHA_22980978_ChIP-Seq_HELA_Human1.81869378
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80508608
27UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.78839283
28TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.78797019
29GATA1_26923725_Chip-Seq_HPCs_Mouse1.76399117
30STAT1_17558387_ChIP-Seq_HELA_Human1.74541005
31NANOG_20526341_ChIP-Seq_ESCs_Human1.74247355
32RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.71810844
33MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.71293343
34ZNF274_21170338_ChIP-Seq_K562_Hela1.70193038
35EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.70130432
36KDM2B_26808549_Chip-Seq_REH_Human1.69858972
37KAP1_22055183_ChIP-Seq_ESCs_Mouse1.68737941
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68426745
39TAL1_26923725_Chip-Seq_HPCs_Mouse1.66741397
40CTCF_27219007_Chip-Seq_Bcells_Human1.65296465
41MYC_19829295_ChIP-Seq_ESCs_Human1.64611875
42GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.61044633
43ELK4_26923725_Chip-Seq_MESODERM_Mouse1.60704931
44ER_23166858_ChIP-Seq_MCF-7_Human1.60341062
45ARNT_22903824_ChIP-Seq_MCF-7_Human1.59807831
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.59052112
47TAF2_19829295_ChIP-Seq_ESCs_Human1.58514065
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.56987519
49WDR5_24793694_ChIP-Seq_LNCAP_Human1.56706824
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54347318
51BCL6_27268052_Chip-Seq_Bcells_Human1.52045254
52CBP_20019798_ChIP-Seq_JUKART_Human1.52019490
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52019490
54AUTS2_25519132_ChIP-Seq_293T-REX_Human1.50817492
55SOX2_22085726_ChIP-Seq_NPCs_Mouse1.50443134
56YY1_22570637_ChIP-Seq_MALME-3M_Human1.50309363
57ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.50138790
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.49542727
59TDRD3_21172665_ChIP-Seq_MCF-7_Human1.49099578
60TAF15_26573619_Chip-Seq_HEK293_Human1.47409139
61TP53_18474530_ChIP-ChIP_U2OS_Human1.46758248
62FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46000394
63PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.45334041
64SMC4_20622854_ChIP-Seq_HELA_Human1.45296732
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44808846
66E2F1_20622854_ChIP-Seq_HELA_Human1.44607705
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.44282841
68CBX2_22325352_ChIP-Seq_293T-Rex_Human1.43259224
69HNFA_21074721_ChIP-Seq_CACO-2_Human1.43188343
70AR_25329375_ChIP-Seq_VCAP_Human1.41898368
71CTCF_20526341_ChIP-Seq_ESCs_Human1.40470323
72OCT4_20526341_ChIP-Seq_ESCs_Human1.39916382
73GATA3_21867929_ChIP-Seq_CD8_Mouse1.39328605
74RBPJ_21746931_ChIP-Seq_IB4_Human1.38814799
75CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38079009
76BCOR_27268052_Chip-Seq_Bcells_Human1.38062469
77P300_19829295_ChIP-Seq_ESCs_Human1.37396350
78TP63_22573176_ChIP-Seq_HFKS_Human1.36394811
79PHF8_20622854_ChIP-Seq_HELA_Human1.36269810
80CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.36257197
81ETV2_25802403_ChIP-Seq_MESCs_Mouse1.35745163
82SMAD3_21741376_ChIP-Seq_ESCs_Human1.35508870
83P68_20966046_ChIP-Seq_HELA_Human1.33742192
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33670606
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33670606
86TP63_19390658_ChIP-ChIP_HaCaT_Human1.33551419
87GATA3_21867929_ChIP-Seq_TH1_Mouse1.32939059
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.32734842
89ETV1_20927104_ChIP-Seq_GIST48_Human1.32119818
90TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31392916
91REST_21632747_ChIP-Seq_MESCs_Mouse1.30794618
92TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27777798
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.27641857
94LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.27247090
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26173204
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25187280
97CRX_20693478_ChIP-Seq_RETINA_Mouse1.25013000
98PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.24645249
99GATA3_21878914_ChIP-Seq_MCF-7_Human1.24332867
100CEBPB_22108803_ChIP-Seq_LS180_Human1.24311072
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24011656
102TBL1_22424771_ChIP-Seq_293T_Human1.23913961
103SMAD4_21741376_ChIP-Seq_HESCs_Human1.23272213
104P53_21459846_ChIP-Seq_SAOS-2_Human1.23046383
105SUZ12_27294783_Chip-Seq_ESCs_Mouse1.22253764
106CMYC_18555785_Chip-Seq_ESCs_Mouse1.22093236
107P300_27268052_Chip-Seq_Bcells_Human1.21146030
108P53_22387025_ChIP-Seq_ESCs_Mouse1.20871359
109SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20813184
110OCT4_18555785_Chip-Seq_ESCs_Mouse1.19929356
111KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17084299
112GF1_26923725_Chip-Seq_HPCs_Mouse1.16970985
113LXR_22292898_ChIP-Seq_THP-1_Human1.16583156
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16484915
115PHF8_20622853_ChIP-Seq_HELA_Human1.16340815
116SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.16198487
117EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15891080
118FUS_26573619_Chip-Seq_HEK293_Human1.15702007
119NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15521025
120CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15122013
121FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14286484
122P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.13784448
123ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13734992
124P300_18555785_Chip-Seq_ESCs_Mouse1.12848583
125SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12810649
126GATA6_21074721_ChIP-Seq_CACO-2_Human1.11653156
127RUNX2_22187159_ChIP-Seq_PCA_Human1.10464880
128MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09023123
129ERG_20517297_ChIP-Seq_VCAP_Human1.08405494
130NANOG_19829295_ChIP-Seq_ESCs_Human1.08339999
131SOX2_19829295_ChIP-Seq_ESCs_Human1.08339999
132RUNX_20019798_ChIP-Seq_JUKART_Human1.08142649
133RAD21_21589869_ChIP-Seq_MESCs_Mouse1.07616609
134OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07482644
135PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07297264
136EZH2_27294783_Chip-Seq_NPCs_Mouse1.07073914
137RNF2_27304074_Chip-Seq_NSC_Mouse1.06731431
138PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.06652074
139EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.06320177
140CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05952628
141SA1_27219007_Chip-Seq_Bcells_Human1.05105030
142SMRT_27268052_Chip-Seq_Bcells_Human1.04801796
143KLF4_18555785_Chip-Seq_ESCs_Mouse1.04276940
144NFYA_21822215_ChIP-Seq_K562_Human1.04077103
145KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.04041505
146EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04005819
147SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03759213
148SOX9_26525672_Chip-Seq_HEART_Mouse1.03376241
149GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03121012
150SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.02907929
151STAT3_23295773_ChIP-Seq_U87_Human1.02284234
152SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02065972
153PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01874879
154SMAD4_21799915_ChIP-Seq_A2780_Human1.01854274
155ESRRB_18555785_Chip-Seq_ESCs_Mouse1.01389346
156ESET_19884257_ChIP-Seq_ESCs_Mouse1.00860009
157SPI1_26923725_Chip-Seq_HPCs_Mouse1.00696321
158E2F1_17053090_ChIP-ChIP_MCF-7_Human1.00008469
159EZH2_27294783_Chip-Seq_ESCs_Mouse0.99642192
160SOX2_18555785_Chip-Seq_ESCs_Mouse0.99494104
161STAT3_18555785_Chip-Seq_ESCs_Mouse0.99010246
162RUNX1_26923725_Chip-Seq_HPCs_Mouse0.98995293
163NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98179186
164PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97661985
165PU1_27457419_Chip-Seq_LIVER_Mouse0.95241763
166CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94911337
167NFYB_21822215_ChIP-Seq_K562_Human0.94198491
168GATA1_19941827_ChIP-Seq_MEL86_Mouse0.93592362
169SMAD4_21741376_ChIP-Seq_EPCs_Human0.93275094
170SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92256363
171E2F1_18555785_Chip-Seq_ESCs_Mouse0.92157866
172GF1B_26923725_Chip-Seq_HPCs_Mouse0.91960723

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.21287693
2MP0001929_abnormal_gametogenesis5.52848125
3MP0008877_abnormal_DNA_methylation3.95951497
4MP0002210_abnormal_sex_determination3.40728294
5MP0002161_abnormal_fertility/fecundity3.39077318
6MP0001145_abnormal_male_reproductive2.88312052
7MP0005670_abnormal_white_adipose2.82618316
8MP0000653_abnormal_sex_gland2.49209263
9MP0002653_abnormal_ependyma_morphology2.45154411
10MP0000678_abnormal_parathyroid_gland2.34714980
11MP0003718_maternal_effect2.21380240
12MP0005410_abnormal_fertilization16.4311710
13MP0002132_abnormal_respiratory_system1.89966382
14MP0005623_abnormal_meninges_morphology1.76417004
15MP0001485_abnormal_pinna_reflex1.74821703
16MP0005379_endocrine/exocrine_gland_phen1.69498432
17MP0009053_abnormal_anal_canal1.69169517
18MP0001486_abnormal_startle_reflex1.64793349
19MP0001984_abnormal_olfaction1.62901750
20MP0005310_abnormal_salivary_gland1.59451294
21MP0002160_abnormal_reproductive_system1.51864328
22MP0004510_myositis1.51461357
23MP0002282_abnormal_trachea_morphology1.49672433
24MP0002249_abnormal_larynx_morphology1.45313541
25MP0005451_abnormal_body_composition1.42644935
26MP0001765_abnormal_ion_homeostasis1.39542744
27MP0004859_abnormal_synaptic_plasticity1.26418043
28MP0004233_abnormal_muscle_weight1.18786669
29MP0003646_muscle_fatigue1.15994309
30MP0001963_abnormal_hearing_physiology1.15117309
31MP0005248_abnormal_Harderian_gland1.09839738
32MP0002138_abnormal_hepatobiliary_system1.09735480
33MP0002127_abnormal_cardiovascular_syste1.06537627
34MP0005647_abnormal_sex_gland1.04910684
35MP0000026_abnormal_inner_ear1.03591990
36MP0002735_abnormal_chemical_nociception1.02106473
37MP0005395_other_phenotype0.97507947
38MP0008995_early_reproductive_senescence0.95618162
39MP0000955_abnormal_spinal_cord0.92410478
40MP0003283_abnormal_digestive_organ0.88156974
41MP0008058_abnormal_DNA_repair0.88091324
42MP0005377_hearing/vestibular/ear_phenot0.86421404
43MP0003878_abnormal_ear_physiology0.86421404
44MP0002822_catalepsy0.85864782
45MP0009046_muscle_twitch0.79199876
46MP0000049_abnormal_middle_ear0.79176533
47MP0002067_abnormal_sensory_capabilities0.78003864
48MP0005083_abnormal_biliary_tract0.77767658
49MP0005636_abnormal_mineral_homeostasis0.77590698
50MP0005389_reproductive_system_phenotype0.76124118
51MP0000681_abnormal_thyroid_gland0.72339823
52MP0005167_abnormal_blood-brain_barrier0.71778033
53MP0004085_abnormal_heartbeat0.71101629
54MP0003115_abnormal_respiratory_system0.70110807
55MP0002733_abnormal_thermal_nociception0.68707714
56MP0002557_abnormal_social/conspecific_i0.67853565
57MP0009697_abnormal_copulation0.67180945
58MP0000516_abnormal_urinary_system0.67068517
59MP0005367_renal/urinary_system_phenotyp0.67068517
60MP0003880_abnormal_central_pattern0.66558233
61MP0003119_abnormal_digestive_system0.64991038
62MP0005666_abnormal_adipose_tissue0.61685738
63MP0002572_abnormal_emotion/affect_behav0.60481773
64MP0001879_abnormal_lymphatic_vessel0.57792392
65MP0001666_abnormal_nutrient_absorption0.57766169
66MP0001905_abnormal_dopamine_level0.57079510
67MP0002928_abnormal_bile_duct0.56784066
68MP0004484_altered_response_of0.55496706
69MP0003137_abnormal_impulse_conducting0.54153558
70MP0001324_abnormal_eye_pigmentation0.52913056
71MP0006292_abnormal_olfactory_placode0.52447603
72MP0004036_abnormal_muscle_relaxation0.51284005
73MP0003077_abnormal_cell_cycle0.50573384
74MP0001764_abnormal_homeostasis0.50547116
75MP0000358_abnormal_cell_content/0.49298127
76MP0001293_anophthalmia0.48826046
77MP0003699_abnormal_female_reproductive0.48676400
78MP0002272_abnormal_nervous_system0.48606032
79MP0000569_abnormal_digit_pigmentation0.48316222
80MP0002234_abnormal_pharynx_morphology0.47923771
81MP0001970_abnormal_pain_threshold0.46081092
82MP0003011_delayed_dark_adaptation0.46072757
83MP0002734_abnormal_mechanical_nocicepti0.45610805
84MP0005084_abnormal_gallbladder_morpholo0.45372192
85MP0005551_abnormal_eye_electrophysiolog0.44452592
86MP0000003_abnormal_adipose_tissue0.43095292
87MP0002139_abnormal_hepatobiliary_system0.42365875
88MP0004019_abnormal_vitamin_homeostasis0.42359946
89MP0008961_abnormal_basal_metabolism0.42069330
90MP0010094_abnormal_chromosome_stability0.41875920
91MP0009115_abnormal_fat_cell0.41194461
92MP0004742_abnormal_vestibular_system0.41056441
93MP0000230_abnormal_systemic_arterial0.40420067
94MP0002102_abnormal_ear_morphology0.40321418
95MP0003950_abnormal_plasma_membrane0.39558034
96MP0005253_abnormal_eye_physiology0.39143451
97MP0005535_abnormal_body_temperature0.38740374
98MP0002736_abnormal_nociception_after0.38694937
99MP0001501_abnormal_sleep_pattern0.38578700
100MP0009745_abnormal_behavioral_response0.38510161
101MP0008875_abnormal_xenobiotic_pharmacok0.38040139
102MP0003329_amyloid_beta_deposits0.37776352
103MP0000470_abnormal_stomach_morphology0.37624252
104MP0000249_abnormal_blood_vessel0.37381314
105MP0005499_abnormal_olfactory_system0.37339055
106MP0005394_taste/olfaction_phenotype0.37339055
107MP0000613_abnormal_salivary_gland0.37321725
108MP0002269_muscular_atrophy0.36858315
109MP0002971_abnormal_brown_adipose0.36744834
110MP0005408_hypopigmentation0.36230719
111MP0008789_abnormal_olfactory_epithelium0.35637205
112MP0002254_reproductive_system_inflammat0.35577631
113MP0003633_abnormal_nervous_system0.33016432
114MP0001119_abnormal_female_reproductive0.32931837
115MP0000534_abnormal_ureter_morphology0.32468798
116MP0005397_hematopoietic_system_phenotyp0.32388251
117MP0001545_abnormal_hematopoietic_system0.32388251
118MP0005391_vision/eye_phenotype0.31855981
119MP0006036_abnormal_mitochondrial_physio0.31797233
120MP0004133_heterotaxia0.31131831
121MP0009278_abnormal_bone_marrow0.31086138
122MP0001849_ear_inflammation0.25382562
123MP0003942_abnormal_urinary_system0.25292173
124MP0003879_abnormal_hair_cell0.24434423
125MP0005365_abnormal_bile_salt0.23740005
126MP0003631_nervous_system_phenotype0.22037017
127MP0004811_abnormal_neuron_physiology0.22022299
128MP0005319_abnormal_enzyme/_coenzyme0.21657159
129MP0006035_abnormal_mitochondrial_morpho0.21378134
130MP0003111_abnormal_nucleus_morphology0.21294867
131MP0001968_abnormal_touch/_nociception0.21059868
132MP0004270_analgesia0.20956766
133MP0001727_abnormal_embryo_implantation0.20605419
134MP0002152_abnormal_brain_morphology0.20386048
135MP0002092_abnormal_eye_morphology0.20361093
136MP0004043_abnormal_pH_regulation0.19897853
137MP0003861_abnormal_nervous_system0.19780193
138MP0000604_amyloidosis0.19777659
139MP0002693_abnormal_pancreas_physiology0.19288133
140MP0002295_abnormal_pulmonary_circulatio0.19093948
141MP0002169_no_abnormal_phenotype0.17671474
142MP0001502_abnormal_circadian_rhythm0.17620002
143MP0003252_abnormal_bile_duct0.17488990
144MP0003786_premature_aging0.17398384
145MP0002873_normal_phenotype0.17376718
146MP0005375_adipose_tissue_phenotype0.17269161
147MP0002118_abnormal_lipid_homeostasis0.16143431
148MP0010329_abnormal_lipoprotein_level0.15856198
149MP0003948_abnormal_gas_homeostasis0.15822114
150MP0008057_abnormal_DNA_replication0.15805119
151MP0004145_abnormal_muscle_electrophysio0.15299153
152MP0001348_abnormal_lacrimal_gland0.15270365
153MP0009672_abnormal_birth_weight0.14903600
154MP0002229_neurodegeneration0.14027714
155MP0008569_lethality_at_weaning0.13782242
156MP0002133_abnormal_respiratory_system0.13599322
157MP0005388_respiratory_system_phenotype0.13599322
158MP0002796_impaired_skin_barrier0.12149507
159MP0001440_abnormal_grooming_behavior0.12007282
160MP0002752_abnormal_somatic_nervous0.11327143
161MP0005423_abnormal_somatic_nervous0.11293497

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.48001832
2Abnormal respiratory motile cilium morphology (HP:0005938)9.48001832
3Abnormal respiratory motile cilium physiology (HP:0012261)9.42944119
4Severe visual impairment (HP:0001141)7.99015601
5Abnormal ciliary motility (HP:0012262)7.96867210
6Rhinitis (HP:0012384)7.20572442
7Chronic bronchitis (HP:0004469)7.05387428
8Infertility (HP:0000789)6.59398096
9Nasal polyposis (HP:0100582)6.16155913
10Abnormality of the nasal mucosa (HP:0000433)5.06502813
11Male infertility (HP:0003251)4.92333929
12Attenuation of retinal blood vessels (HP:0007843)4.77703474
13Bony spicule pigmentary retinopathy (HP:0007737)4.71496437
14Resting tremor (HP:0002322)4.61902258
15Bronchitis (HP:0012387)4.43321716
16Bronchiectasis (HP:0002110)4.39178804
17Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.35752219
18Nephronophthisis (HP:0000090)4.17828453
19Hyperkalemia (HP:0002153)4.14816059
20Abnormality of macular pigmentation (HP:0008002)4.09350948
21Cone-rod dystrophy (HP:0000548)4.00682276
22Aplasia/Hypoplasia of the earlobes (HP:0009906)3.83779915
23Enlarged epiphyses (HP:0010580)3.78335341
24Hypoplastic ischia (HP:0003175)3.70200906
25Recurrent sinusitis (HP:0011108)3.67395320
26Abnormal rod and cone electroretinograms (HP:0008323)3.66122416
27Facial shape deformation (HP:0011334)3.66065730
28Potter facies (HP:0002009)3.66065730
29Abnormal spermatogenesis (HP:0008669)3.60574611
30Progressive sensorineural hearing impairment (HP:0000408)3.41693465
31Hypoplasia of the thymus (HP:0000778)3.34877439
32Tubulointerstitial nephritis (HP:0001970)3.34236552
33Abnormality of the ischium (HP:0003174)3.32388587
34Hypoalphalipoproteinemia (HP:0003233)3.27907433
35Recurrent otitis media (HP:0000403)3.21830565
36Abnormality of the renal medulla (HP:0100957)3.20246036
37Amelogenesis imperfecta (HP:0000705)3.09938675
38Postural instability (HP:0002172)2.98846316
39Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.91167627
40Double outlet right ventricle (HP:0001719)2.88462753
41Congenital malformation of the right heart (HP:0011723)2.88462753
42Menstrual irregularities (HP:0000858)2.83988280
43Abnormality of dental color (HP:0011073)2.83184136
44Unilateral renal agenesis (HP:0000122)2.73891161
45Progressive cerebellar ataxia (HP:0002073)2.72870087
46Portal hypertension (HP:0001409)2.69049343
47Recurrent bronchitis (HP:0002837)2.68611241
48Abnormality of the aortic arch (HP:0012303)2.67788135
49Insulin-resistant diabetes mellitus (HP:0000831)2.64136629
50Renovascular hypertension (HP:0100817)2.62830100
51Generalized aminoaciduria (HP:0002909)2.60959669
52Tubular atrophy (HP:0000092)2.60957982
53Molar tooth sign on MRI (HP:0002419)2.59030770
54Abnormality of midbrain morphology (HP:0002418)2.59030770
55Tubulointerstitial abnormality (HP:0001969)2.56309047
56Abnormality of the costochondral junction (HP:0000919)2.52606585
57Abnormality of the hepatic vasculature (HP:0006707)2.45998577
58Abnormality of potassium homeostasis (HP:0011042)2.38008034
59Ventricular tachycardia (HP:0004756)2.37602621
60Medial flaring of the eyebrow (HP:0010747)2.35919599
61Focal segmental glomerulosclerosis (HP:0000097)2.32435444
62Abnormality of the parathyroid morphology (HP:0011766)2.31746478
63Impulsivity (HP:0100710)2.28921504
64Intellectual disability, moderate (HP:0002342)2.24437917
65Azoospermia (HP:0000027)2.23172313
66Cholecystitis (HP:0001082)2.20532282
67Abnormal gallbladder physiology (HP:0012438)2.20532282
68Progressive hearing impairment (HP:0001730)2.20341509
69Osteomalacia (HP:0002749)2.17413870
70Polyuria (HP:0000103)2.14167677
71Flattened epiphyses (HP:0003071)2.13731715
72Gonadotropin excess (HP:0000837)2.13414211
73Dyschromatopsia (HP:0007641)2.13040918
74Epiphyseal dysplasia (HP:0002656)2.11818982
75Hyperuricemia (HP:0002149)2.11687441
76Increased purine levels (HP:0004368)2.11687441
77Hypophosphatemic rickets (HP:0004912)2.05571388
78Asymmetric septal hypertrophy (HP:0001670)2.01705422
79Dynein arm defect of respiratory motile cilia (HP:0012255)13.9371967
80Absent/shortened dynein arms (HP:0200106)13.9371967
81Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.7654248
82Absent epiphyses (HP:0010577)1.94756229
83Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.94756229
84Abnormality of the epiphysis of the femoral head (HP:0010574)1.93919950
85Recurrent pneumonia (HP:0006532)1.93423234
86Myokymia (HP:0002411)1.93029144
87Hyponatremia (HP:0002902)1.91763176
88Abnormality of the pubic bones (HP:0003172)1.90441906
89Decreased central vision (HP:0007663)1.88874766
90Widely patent fontanelles and sutures (HP:0004492)1.87550102
91Postaxial foot polydactyly (HP:0001830)1.86846770
92Bradycardia (HP:0001662)1.85442797
93Tubulointerstitial fibrosis (HP:0005576)1.83392484
94Stage 5 chronic kidney disease (HP:0003774)1.82534133
95Abnormality of dentin (HP:0010299)1.82160684
96Glomerulosclerosis (HP:0000096)1.81830058
97Heterotopia (HP:0002282)1.81188828
98Abnormality of femoral epiphyses (HP:0006499)1.80578809
99Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.80578809
100Abnormal ventriculo-arterial connection (HP:0011563)1.80004664
101Transposition of the great arteries (HP:0001669)1.80004664
102Abnormal connection of the cardiac segments (HP:0011545)1.80004664
103Renal Fanconi syndrome (HP:0001994)1.79588980
104Tetany (HP:0001281)1.77127062
105Recurrent corneal erosions (HP:0000495)1.76385726
106Subcapsular cataract (HP:0000523)1.75953717
107Spastic tetraparesis (HP:0001285)1.75717595
108Abnormal biliary tract physiology (HP:0012439)1.73666579
109Bile duct proliferation (HP:0001408)1.73666579
110Abnormality of the renal cortex (HP:0011035)1.73378210
111Polydipsia (HP:0001959)1.73233984
112Abnormal drinking behavior (HP:0030082)1.73233984
113Abnormality of the femoral head (HP:0003368)1.72977402
114Choroideremia (HP:0001139)1.72586978
115Abnormality of the dental pulp (HP:0006479)1.71428698
116Abnormality of renal excretion (HP:0011036)1.70942756
117Bell-shaped thorax (HP:0001591)1.69307595
118Congenital hepatic fibrosis (HP:0002612)1.68231438
119Abnormality of permanent molar morphology (HP:0011071)1.67824162
120Abnormality of the dental root (HP:0006486)1.67824162
121Taurodontia (HP:0000679)1.67824162
122Hemorrhage of the eye (HP:0011885)1.61893605
123Abnormality of molar morphology (HP:0011070)1.57236837
124Abnormality of molar (HP:0011077)1.57236837
125Bundle branch block (HP:0011710)1.56624359
126Short ribs (HP:0000773)1.53089097
127Oculomotor apraxia (HP:0000657)1.53011060
128Constricted visual fields (HP:0001133)1.46607484
129Abnormality of the lower motor neuron (HP:0002366)1.45467367
130Chronic sinusitis (HP:0011109)1.45370507
131Cystic liver disease (HP:0006706)1.45016951
132Postaxial hand polydactyly (HP:0001162)1.44654609
133Fibular hypoplasia (HP:0003038)1.38453548
134Hypoplasia of the capital femoral epiphysis (HP:0003090)1.35958854
135Vascular calcification (HP:0004934)1.35723309
136Abnormal urine output (HP:0012590)1.32733871
137Absent frontal sinuses (HP:0002688)1.31997568
138Pancreatic fibrosis (HP:0100732)1.31853535
139Facial cleft (HP:0002006)1.30910011
140Microglossia (HP:0000171)1.29938864
141Chronic hepatic failure (HP:0100626)1.29724971
142Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.28602305
143Decreased electroretinogram (ERG) amplitude (HP:0000654)1.28554458
144Aplasia/Hypoplasia of the lens (HP:0008063)1.28535747
145Aplasia/Hypoplasia of the tongue (HP:0010295)1.27404996
146Gait imbalance (HP:0002141)1.26769230
147Congenital primary aphakia (HP:0007707)1.26526437
148Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.25784498
149Renal dysplasia (HP:0000110)1.25043793
150Optic nerve hypoplasia (HP:0000609)1.23373992
151Cardiovascular calcification (HP:0011915)1.22320445
152Supernumerary spleens (HP:0009799)1.21491849
153Short thorax (HP:0010306)1.20693839
154Hemiparesis (HP:0001269)1.20487570
155Nephropathy (HP:0000112)1.17470799
156Truncal obesity (HP:0001956)1.17465812
157Amyotrophic lateral sclerosis (HP:0007354)1.16746256
158True hermaphroditism (HP:0010459)1.16441406
159Deformed sella turcica (HP:0002681)1.15792181
160Abnormality of saccadic eye movements (HP:0000570)1.15629396
161Optic neuritis (HP:0100653)1.15401566
162Retrobulbar optic neuritis (HP:0100654)1.15401566
163J-shaped sella turcica (HP:0002680)1.15235849
164Neurofibrillary tangles (HP:0002185)1.14346181
165Median cleft lip (HP:0000161)1.14002386
166Hypercholesterolemia (HP:0003124)1.10741091
167Broad distal phalanx of finger (HP:0009836)1.10161715

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK39.27771977
2PDK49.27771977
3PDK26.03837638
4TESK14.78112031
5DDR24.64524178
6INSRR4.61228607
7PRKD34.26315272
8BRD43.73952379
9ICK3.62685401
10PLK23.55483920
11MAP4K23.32325200
12PIK3CG2.13033331
13PNCK2.01944620
14PTK2B1.96166168
15WNK41.80855086
16STK391.73252672
17MST1R1.47484012
18DYRK1B1.34487039
19STK381.25463071
20CDK71.20478583
21NEK21.17273975
22PDK11.11533868
23MAP3K90.96998298
24KSR20.92482181
25TYRO30.87189407
26CAMK1D0.84456293
27AKT30.84248914
28LMTK20.82220998
29MAPK150.75571203
30DYRK30.74018005
31IRAK10.73646979
32MAP2K60.72344874
33WNK10.71944551
34CAMK1G0.69133861
35MAP3K110.67983437
36LATS20.65777472
37BRAF0.65268477
38UHMK10.64168181
39RPS6KA20.62351546
40PDPK10.57319406
41PRKAA20.57181725
42TTK0.55223227
43TIE10.54544365
44STK30.53376702
45CAMK10.53257702
46MAP3K20.53025264
47BMPR1B0.52088401
48MARK10.51940711
49MAP2K20.50366132
50ROCK10.49405274
51SIK20.49016776
52PASK0.48798834
53CHEK20.48501716
54CDK30.46520550
55RIPK40.46077218
56EEF2K0.45362993
57MAP3K80.42655357
58IRAK20.40748087
59PINK10.39891781
60MAPK10.39031699
61CCNB10.38061318
62CHEK10.37827129
63SGK2230.37744097
64SGK4940.37744097
65CAMK40.35254083
66PAK10.34943411
67PLK40.34743482
68NTRK30.33781422
69PAK20.33739328
70STK38L0.30490042
71RPS6KC10.28934793
72RPS6KL10.28934793
73PRKCG0.26757519
74RPS6KA60.26682018
75ARAF0.25471463
76ACVR1B0.25133238
77ATM0.24789882
78NTRK20.24103136
79NEK60.23993789
80MTOR0.23965674
81MAP3K10.23422041
82TESK20.22182117
83CDC70.21648856
84MUSK0.21179843
85TNIK0.20603796
86SGK10.20306547
87MAPK140.20005270
88OXSR10.19910993
89ATR0.19673878
90PRKAA10.18426520
91MAPK100.18005402
92WEE10.17243967
93FER0.16034516
94CAMKK10.15828763
95MARK20.15380095
96MET0.15057122
97MAP3K100.13955531
98AKT10.13668574
99MAPKAPK50.12777251
100PRKCZ0.12624606
101CSNK1D0.11323873
102RPS6KB10.11100310
103BLK0.10859492
104JAK30.10778979
105CDK60.09979898
106PAK40.09325623
107MAPK110.08960469
108PLK10.08853591
109PRKG20.08546347
110PRKCQ0.08193964
111CHUK0.08095923
112SGK20.07095816
113GSK3B0.07079475
114CDK120.06823025
115MAPK90.06273969
116WNK30.05910936
117CDK150.05259216
118MAP3K40.05238630
119CAMK2A0.04974789
120PKN10.04674524
121MAP3K50.04544466
122YES10.04033483
123PRKACG0.03977906
124PRKG10.03910530
125STK110.03385796
126CSNK2A10.03123962
127CDK180.02819750
128PRKCB0.02680266
129CDK10.02463098
130PRKCE0.02444127
131CDK20.02401768
132RIPK10.02008963
133CSNK2A20.01913037
134RPS6KA10.01631818
135CDK11A0.01623985
136PAK60.00871456
137BRSK20.00697272
138MAPK80.00654869
139PRKCD0.00469974
140CDK140.00321385
141PRKCA0.00318501
142PRKACA-0.0164024
143SRC-0.0138745
144CDK4-0.0138571
145LATS1-0.0128417
146MARK3-0.0123520
147CSNK1E-0.0112503
148MAP2K7-0.0111615
149PRKDC-0.0057584
150GSK3A-0.0053412
151RPS6KA3-0.0042933
152PRKACB-0.0030981
153BRSK1-0.0022013
154EGFR-0.0016124

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.60820369
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.73453519
3Fatty acid biosynthesis_Homo sapiens_hsa000614.13997478
4Pyruvate metabolism_Homo sapiens_hsa006203.56127436
5Vitamin B6 metabolism_Homo sapiens_hsa007503.25830180
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.03024876
7Propanoate metabolism_Homo sapiens_hsa006402.80600216
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.64781569
9Butanoate metabolism_Homo sapiens_hsa006502.57103046
10Linoleic acid metabolism_Homo sapiens_hsa005912.55752508
11Glucagon signaling pathway_Homo sapiens_hsa049222.48443309
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.34566358
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.33365824
14Glycosaminoglycan degradation_Homo sapiens_hsa005312.13889509
15Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.09795000
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.08417273
17Glycerolipid metabolism_Homo sapiens_hsa005611.97649949
18Phenylalanine metabolism_Homo sapiens_hsa003601.88988265
19Selenocompound metabolism_Homo sapiens_hsa004501.81593390
20PPAR signaling pathway_Homo sapiens_hsa033201.78697679
21Oocyte meiosis_Homo sapiens_hsa041141.76232544
22Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.76108002
23Basal transcription factors_Homo sapiens_hsa030221.73139015
24Mineral absorption_Homo sapiens_hsa049781.68181708
25Type I diabetes mellitus_Homo sapiens_hsa049401.63128747
26Dorso-ventral axis formation_Homo sapiens_hsa043201.59569884
27Allograft rejection_Homo sapiens_hsa053301.58915893
28Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.55764914
29Autoimmune thyroid disease_Homo sapiens_hsa053201.55585718
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.54192426
31Glycerophospholipid metabolism_Homo sapiens_hsa005641.53573714
32Graft-versus-host disease_Homo sapiens_hsa053321.42347305
33Carbon metabolism_Homo sapiens_hsa012001.39420498
34Fructose and mannose metabolism_Homo sapiens_hsa000511.36760513
35Fatty acid degradation_Homo sapiens_hsa000711.33179998
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32543894
37Pentose phosphate pathway_Homo sapiens_hsa000301.30418022
38Amphetamine addiction_Homo sapiens_hsa050311.24607969
39Arginine and proline metabolism_Homo sapiens_hsa003301.23841991
40Fatty acid metabolism_Homo sapiens_hsa012121.23628018
41Ether lipid metabolism_Homo sapiens_hsa005651.20416119
42Cardiac muscle contraction_Homo sapiens_hsa042601.19964485
43Viral myocarditis_Homo sapiens_hsa054161.19186939
44Collecting duct acid secretion_Homo sapiens_hsa049661.17804169
45Antigen processing and presentation_Homo sapiens_hsa046121.16910178
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.15390131
47Phototransduction_Homo sapiens_hsa047441.15159102
48Glutathione metabolism_Homo sapiens_hsa004801.12422921
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09336148
50Fat digestion and absorption_Homo sapiens_hsa049751.08863124
51Renin secretion_Homo sapiens_hsa049241.07407129
52Thyroid hormone synthesis_Homo sapiens_hsa049181.06990516
53Bile secretion_Homo sapiens_hsa049761.05547304
54Fanconi anemia pathway_Homo sapiens_hsa034601.02505662
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00898353
56mRNA surveillance pathway_Homo sapiens_hsa030150.97166641
57Biosynthesis of amino acids_Homo sapiens_hsa012300.95523653
58Arginine biosynthesis_Homo sapiens_hsa002200.94497133
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93441814
60Insulin secretion_Homo sapiens_hsa049110.92744126
61Purine metabolism_Homo sapiens_hsa002300.92391799
62Huntingtons disease_Homo sapiens_hsa050160.91037924
63Chemical carcinogenesis_Homo sapiens_hsa052040.86335924
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.82822574
65Morphine addiction_Homo sapiens_hsa050320.81944097
66Influenza A_Homo sapiens_hsa051640.81106342
67Arachidonic acid metabolism_Homo sapiens_hsa005900.80847132
68Nicotine addiction_Homo sapiens_hsa050330.80618360
69Salivary secretion_Homo sapiens_hsa049700.79838165
70Tyrosine metabolism_Homo sapiens_hsa003500.78935640
71Inositol phosphate metabolism_Homo sapiens_hsa005620.77867023
72Estrogen signaling pathway_Homo sapiens_hsa049150.76263044
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75832921
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75459135
75ABC transporters_Homo sapiens_hsa020100.73626015
76RNA transport_Homo sapiens_hsa030130.73169772
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.70485633
78Hedgehog signaling pathway_Homo sapiens_hsa043400.69446801
79Protein digestion and absorption_Homo sapiens_hsa049740.68963382
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66222471
81Gastric acid secretion_Homo sapiens_hsa049710.65097471
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65042315
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64818540
84Calcium signaling pathway_Homo sapiens_hsa040200.63839123
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61562611
86Pancreatic secretion_Homo sapiens_hsa049720.61197470
87Synaptic vesicle cycle_Homo sapiens_hsa047210.60497252
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.60186026
89Sulfur metabolism_Homo sapiens_hsa009200.58360619
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57571866
91Taste transduction_Homo sapiens_hsa047420.56781425
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.54984017
93Legionellosis_Homo sapiens_hsa051340.54294688
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52206101
95Long-term potentiation_Homo sapiens_hsa047200.52062208
96Olfactory transduction_Homo sapiens_hsa047400.51833155
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50610443
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50537763
99Renin-angiotensin system_Homo sapiens_hsa046140.49498629
100Serotonergic synapse_Homo sapiens_hsa047260.46354956
101Circadian entrainment_Homo sapiens_hsa047130.45189648
102cAMP signaling pathway_Homo sapiens_hsa040240.42865385
103Endocytosis_Homo sapiens_hsa041440.40515110
104Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40234610
105Tight junction_Homo sapiens_hsa045300.38914118
106MAPK signaling pathway_Homo sapiens_hsa040100.38230360
107Metabolic pathways_Homo sapiens_hsa011000.37127448
108Cholinergic synapse_Homo sapiens_hsa047250.35551500
109Acute myeloid leukemia_Homo sapiens_hsa052210.34850832
110AMPK signaling pathway_Homo sapiens_hsa041520.34733785
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.32491705
112GABAergic synapse_Homo sapiens_hsa047270.29242113
113Nitrogen metabolism_Homo sapiens_hsa009100.28857606
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26811121
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.26041532
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25639357
117Systemic lupus erythematosus_Homo sapiens_hsa053220.24701643
118Oxytocin signaling pathway_Homo sapiens_hsa049210.24509143
119ECM-receptor interaction_Homo sapiens_hsa045120.23544269
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.20889389
121Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20036114
122Prolactin signaling pathway_Homo sapiens_hsa049170.19973318
123Viral carcinogenesis_Homo sapiens_hsa052030.17368658
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16215706
125VEGF signaling pathway_Homo sapiens_hsa043700.15903486
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.15555652
127Herpes simplex infection_Homo sapiens_hsa051680.14910116
128Adherens junction_Homo sapiens_hsa045200.14786995
129Retinol metabolism_Homo sapiens_hsa008300.13158994
130Vibrio cholerae infection_Homo sapiens_hsa051100.10222774
131HIF-1 signaling pathway_Homo sapiens_hsa040660.10120679
132Complement and coagulation cascades_Homo sapiens_hsa046100.07440542
133Type II diabetes mellitus_Homo sapiens_hsa049300.06550829
134Glutamatergic synapse_Homo sapiens_hsa047240.06379467
135Cocaine addiction_Homo sapiens_hsa050300.06033147
136Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.05154777
137Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.03908024

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