CABLES2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1urea cycle (GO:0000050)5.39026627
2urea metabolic process (GO:0019627)5.39026627
3L-phenylalanine catabolic process (GO:0006559)4.95950462
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.95950462
5kynurenine metabolic process (GO:0070189)4.83174972
6nucleosome disassembly (GO:0006337)4.79066213
7protein-DNA complex disassembly (GO:0032986)4.79066213
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.72641997
9nitrogen cycle metabolic process (GO:0071941)4.70249714
10dicarboxylic acid biosynthetic process (GO:0043650)4.69673507
11aromatic amino acid family catabolic process (GO:0009074)4.66453797
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.60208547
13L-phenylalanine metabolic process (GO:0006558)4.60208547
14regulation of cholesterol esterification (GO:0010872)4.56264377
15negative regulation of sterol transport (GO:0032372)4.50528336
16negative regulation of cholesterol transport (GO:0032375)4.50528336
17tryptophan catabolic process (GO:0006569)4.43418227
18indole-containing compound catabolic process (GO:0042436)4.43418227
19indolalkylamine catabolic process (GO:0046218)4.43418227
20negative regulation of fibrinolysis (GO:0051918)4.34646396
21mitotic chromosome condensation (GO:0007076)4.34397812
22high-density lipoprotein particle remodeling (GO:0034375)4.27165016
23chromosome condensation (GO:0030261)4.24665210
24alpha-linolenic acid metabolic process (GO:0036109)4.09434076
25regulation of fibrinolysis (GO:0051917)4.00368008
26atrioventricular valve morphogenesis (GO:0003181)3.98758850
27tryptophan metabolic process (GO:0006568)3.98106050
28complement activation, alternative pathway (GO:0006957)3.95488859
29regulation of protein activation cascade (GO:2000257)3.91786843
30bile acid biosynthetic process (GO:0006699)3.88092730
31DNA packaging (GO:0006323)3.81012356
32regulation of NFAT protein import into nucleus (GO:0051532)3.78336797
33regulation of fatty acid beta-oxidation (GO:0031998)3.76703817
34cell-cell junction maintenance (GO:0045217)3.74186695
35serine family amino acid catabolic process (GO:0009071)3.74182777
36acylglycerol homeostasis (GO:0055090)3.71191207
37triglyceride homeostasis (GO:0070328)3.71191207
38intracellular estrogen receptor signaling pathway (GO:0030520)3.68209071
39GDP-mannose metabolic process (GO:0019673)3.65514792
40cellular ketone body metabolic process (GO:0046950)3.63860745
41cell migration in hindbrain (GO:0021535)3.63313119
42regulation of mammary gland epithelial cell proliferation (GO:0033599)3.63220615
43regulation of triglyceride catabolic process (GO:0010896)3.62941354
44regulation of complement activation (GO:0030449)3.60105642
45ribosomal small subunit biogenesis (GO:0042274)3.59413813
46protein carboxylation (GO:0018214)3.57933647
47peptidyl-glutamic acid carboxylation (GO:0017187)3.57933647
48glyoxylate metabolic process (GO:0046487)3.54899827
49regulation of chromatin binding (GO:0035561)3.53967899
50pyrimidine nucleobase catabolic process (GO:0006208)3.51595686
51antigen processing and presentation of endogenous antigen (GO:0019883)3.50303452
52reverse cholesterol transport (GO:0043691)3.48590327
53plasma lipoprotein particle clearance (GO:0034381)3.48014794
54regulation of gamma-delta T cell differentiation (GO:0045586)3.47777482
55glutamate metabolic process (GO:0006536)3.47274236
56protein-lipid complex remodeling (GO:0034368)3.46744583
57macromolecular complex remodeling (GO:0034367)3.46744583
58plasma lipoprotein particle remodeling (GO:0034369)3.46744583
59heterochromatin organization (GO:0070828)3.44259098
60positive regulation of gamma-delta T cell activation (GO:0046645)3.43888879
61DNA unwinding involved in DNA replication (GO:0006268)3.43161366
62bile acid metabolic process (GO:0008206)3.42871412
63histone phosphorylation (GO:0016572)3.40451305
64cysteine metabolic process (GO:0006534)3.39570467
65phospholipid efflux (GO:0033700)3.39354271
66body morphogenesis (GO:0010171)3.38770743
67lysine catabolic process (GO:0006554)3.38104984
68lysine metabolic process (GO:0006553)3.38104984
69positive regulation of B cell differentiation (GO:0045579)3.36752903
70atrial septum morphogenesis (GO:0060413)3.34847141
71regulation of cholesterol homeostasis (GO:2000188)3.32808288
72phospholipid homeostasis (GO:0055091)3.30121070
73bile acid and bile salt transport (GO:0015721)3.29833032
74maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.29581236
75antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.28292300
76antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.28292300
77mitotic G1 DNA damage checkpoint (GO:0031571)3.27343682
78nucleobase catabolic process (GO:0046113)3.23511271
79planar cell polarity pathway involved in neural tube closure (GO:0090179)3.23138561
80meiotic chromosome segregation (GO:0045132)3.22699597
81regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.22040318
82positive regulation of lipid catabolic process (GO:0050996)3.20394074
83complement activation, classical pathway (GO:0006958)3.19281713
84protein retention in ER lumen (GO:0006621)3.19044090
85fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.17964418
86DNA replication checkpoint (GO:0000076)3.17592952
87ethanol oxidation (GO:0006069)3.15245627
88arginine metabolic process (GO:0006525)3.15165190
89regulation of bile acid biosynthetic process (GO:0070857)3.11603456
90regulation of interleukin-12 biosynthetic process (GO:0045075)3.11577807
91positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.09093409
92plasma lipoprotein particle assembly (GO:0034377)3.08308681
93negative regulation of cell killing (GO:0031342)3.07580380
94negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.07580380
95homocysteine metabolic process (GO:0050667)3.07127395
96alpha-amino acid catabolic process (GO:1901606)3.07102300
97chromatin silencing (GO:0006342)3.07076066
98sulfur amino acid catabolic process (GO:0000098)3.07042725
99mitotic G1/S transition checkpoint (GO:0044819)3.06173384
100regulation of humoral immune response (GO:0002920)3.04522711
101regulation of gamma-delta T cell activation (GO:0046643)3.04029206
102regulation of histone H3-K27 methylation (GO:0061085)3.03214965
103aromatic amino acid family metabolic process (GO:0009072)3.02696800
104negative regulation of lipase activity (GO:0060192)3.02361182
105positive regulation of DNA-dependent DNA replication (GO:2000105)3.00437659
106G1 DNA damage checkpoint (GO:0044783)3.00363444
107ketone body metabolic process (GO:1902224)2.99246428
108midgut development (GO:0007494)2.96308847
109folic acid metabolic process (GO:0046655)2.94544603
110blood coagulation, intrinsic pathway (GO:0007597)2.94016504
111negative regulation of cell size (GO:0045792)2.93744738
112complement activation (GO:0006956)2.93736525
113cholesterol homeostasis (GO:0042632)2.91890600
114regulation of lipid catabolic process (GO:0050994)2.91183164
1152-oxoglutarate metabolic process (GO:0006103)2.90509470
116protein-lipid complex assembly (GO:0065005)2.90310739
117indolalkylamine metabolic process (GO:0006586)2.89683366
118mitotic sister chromatid cohesion (GO:0007064)2.89335925
119adenine nucleotide transport (GO:0051503)2.88765999
120diaphragm development (GO:0060539)2.88377829
121sterol homeostasis (GO:0055092)2.88297447
122positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.88249893
123positive regulation of gene expression, epigenetic (GO:0045815)2.87499059
124cytolysis (GO:0019835)2.87264187
125cholesterol efflux (GO:0033344)2.86938749
126protein localization to chromosome, centromeric region (GO:0071459)2.86248385
127protein activation cascade (GO:0072376)2.86090249
128killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.85920693
129disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.85920693
130skeletal muscle organ development (GO:0060538)2.84587677
131negative regulation of histone methylation (GO:0031061)2.83779397
132benzene-containing compound metabolic process (GO:0042537)2.82960020
133positive regulation of lipoprotein lipase activity (GO:0051006)2.82281840
134positive regulation of triglyceride lipase activity (GO:0061365)2.82281840
135glycine metabolic process (GO:0006544)2.82240276
136embryonic body morphogenesis (GO:0010172)2.81986948
137glucocorticoid receptor signaling pathway (GO:0042921)2.81378480
138amino-acid betaine metabolic process (GO:0006577)2.80779665
139focal adhesion assembly (GO:0048041)2.80509907
140cell-substrate adherens junction assembly (GO:0007045)2.80509907
141regulation of B cell differentiation (GO:0045577)2.80405354
142DNA conformation change (GO:0071103)2.80061513
143imidazole-containing compound metabolic process (GO:0052803)2.79318904
144corticosteroid receptor signaling pathway (GO:0031958)2.77073698
145acute-phase response (GO:0006953)2.76734617
146adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.76424513
147activation of Rac GTPase activity (GO:0032863)2.74226853
148regulation of sterol transport (GO:0032371)2.73278366
149regulation of cholesterol transport (GO:0032374)2.73278366
150positive regulation of histone deacetylation (GO:0031065)2.72834202
151regulation of translational fidelity (GO:0006450)2.72067096
152mitotic sister chromatid segregation (GO:0000070)2.71251699
153DNA strand renaturation (GO:0000733)2.71167221
154regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.70783861
155regulation of glycogen (starch) synthase activity (GO:2000465)2.70304568
156mRNA stabilization (GO:0048255)2.68033938
157RNA stabilization (GO:0043489)2.68033938
158DNA strand elongation (GO:0022616)2.67941088
159adherens junction assembly (GO:0034333)2.64868671
160apoptotic process involved in morphogenesis (GO:0060561)2.61349288
161protein insertion into membrane (GO:0051205)2.60476363
162rRNA methylation (GO:0031167)2.59155462
163DNA strand elongation involved in DNA replication (GO:0006271)2.56941856
164convergent extension (GO:0060026)2.56367530
165spliceosomal tri-snRNP complex assembly (GO:0000244)2.56295454
166RNA localization (GO:0006403)2.55233456
167modulation by virus of host process (GO:0019054)2.54623847
168regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.52816826
169stress granule assembly (GO:0034063)2.52424688
170negative regulation of gene expression, epigenetic (GO:0045814)2.52267520
171DNA topological change (GO:0006265)2.50589131
172semaphorin-plexin signaling pathway (GO:0071526)2.50304185
173sister chromatid segregation (GO:0000819)2.47523465
174histone H4 deacetylation (GO:0070933)2.44782107
175heart valve formation (GO:0003188)2.44500519
176ear development (GO:0043583)2.43975236
177DNA duplex unwinding (GO:0032508)2.42666436
178endothelial cell chemotaxis (GO:0035767)2.41765380
179chromatin assembly (GO:0031497)2.38990802
180nuclear pore complex assembly (GO:0051292)2.38668210
181DNA replication initiation (GO:0006270)2.38639218
182peptidyl-threonine phosphorylation (GO:0018107)2.38379249
183modulation by virus of host morphology or physiology (GO:0019048)2.37390625
184placenta blood vessel development (GO:0060674)2.37352298
185mRNA cleavage (GO:0006379)2.36892166
186histone H2B ubiquitination (GO:0033523)2.33342187
187regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.32444131
188positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.32444131
189cell junction maintenance (GO:0034331)2.31746419
190positive regulation by host of viral transcription (GO:0043923)2.31700448
191urinary tract smooth muscle contraction (GO:0014848)2.29892655
192layer formation in cerebral cortex (GO:0021819)2.29566793
193positive regulation of synapse maturation (GO:0090129)2.28840564
194telomere maintenance via semi-conservative replication (GO:0032201)2.28750761
195DNA geometric change (GO:0032392)2.28636644
196camera-type eye morphogenesis (GO:0048593)2.28398578
197regulation of RNA export from nucleus (GO:0046831)2.27834809
198UV protection (GO:0009650)2.27571132
199protein localization to microtubule (GO:0035372)2.26290045

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.09620725
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.70160939
3E2F7_22180533_ChIP-Seq_HELA_Human4.55127438
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.20515009
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.75098019
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.21431292
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.19100236
8MYC_22102868_ChIP-Seq_BL_Human3.07820794
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.05367013
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.98220867
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.96358643
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.94819648
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.84681704
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.52382518
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.47747204
16TCF7_22412390_ChIP-Seq_EML_Mouse2.37483530
17DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.36913093
18KDM2B_26808549_Chip-Seq_SUP-B15_Human2.29502735
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.22065543
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.19851137
21KDM2B_26808549_Chip-Seq_DND41_Human2.05088405
22KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.04264518
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.01644543
24XRN2_22483619_ChIP-Seq_HELA_Human1.98590049
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.96528185
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.93754190
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.90964349
28* P68_20966046_ChIP-Seq_HELA_Human1.90599997
29RUNX_20019798_ChIP-Seq_JUKART_Human1.89037405
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.87461592
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.85607247
32SCL_19346495_ChIP-Seq_HPC-7_Human1.84337124
33TET1_21451524_ChIP-Seq_MESCs_Mouse1.81908519
34VDR_21846776_ChIP-Seq_THP-1_Human1.81889712
35CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.79626325
36CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.77702108
37MAF_26560356_Chip-Seq_TH1_Human1.76329127
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.73987291
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.71253980
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.71125025
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.71023005
42ZNF263_19887448_ChIP-Seq_K562_Human1.70250773
43KDM2B_26808549_Chip-Seq_JURKAT_Human1.69184763
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.68902162
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.67757550
46EZH2_22144423_ChIP-Seq_EOC_Human1.66221026
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64215494
48* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.61535604
49MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.60162673
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59590315
51SMC4_20622854_ChIP-Seq_HELA_Human1.58269120
52LXR_22292898_ChIP-Seq_THP-1_Human1.57557276
53UTX_26944678_Chip-Seq_JUKART_Human1.52070887
54CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.51932791
55EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.50489656
56CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.49693104
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.47371218
58PKCTHETA_26484144_Chip-Seq_BREAST_Human1.45072979
59CTCF_27219007_Chip-Seq_Bcells_Human1.44952620
60GATA1_22025678_ChIP-Seq_K562_Human1.44360832
61KDM2B_26808549_Chip-Seq_K562_Human1.44325809
62CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.44048938
63* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38496900
64FOXA2_19822575_ChIP-Seq_HepG2_Human1.37683782
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.37088117
66ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.36542983
67MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.35553323
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.35453696
69RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34363318
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33231357
71SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31923179
72FOXP1_21924763_ChIP-Seq_HESCs_Human1.31580461
73MYC_18555785_ChIP-Seq_MESCs_Mouse1.31073999
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29843724
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.27994777
76TP53_22127205_ChIP-Seq_IMR90_Human1.25838149
77RARA_24833708_ChIP-Seq_LIVER_Mouse1.25520863
78MYB_26560356_Chip-Seq_TH1_Human1.25088672
79TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.24802043
80CIITA_25753668_ChIP-Seq_RAJI_Human1.24531569
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.23945739
82GATA1_19941827_ChIP-Seq_MEL_Mouse1.23489746
83MYC_18358816_ChIP-ChIP_MESCs_Mouse1.23382611
84DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.22440178
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22038265
86BCOR_27268052_Chip-Seq_Bcells_Human1.21967954
87SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21605471
88* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21142369
89* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21073217
90KDM5A_27292631_Chip-Seq_BREAST_Human1.20823322
91* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19860852
92* CTCF_21964334_Chip-Seq_Bcells_Human1.19755760
93CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.19476767
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18701524
95SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.17057267
96DROSHA_22980978_ChIP-Seq_HELA_Human1.17012763
97TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16925467
98DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16631957
99RUNX1_27514584_Chip-Seq_MCF-7_Human1.15527774
100RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14105834
101VDR_24763502_ChIP-Seq_THP-1_Human1.13628343
102NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12832203
103ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12168863
104SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11772279
105TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11729581
106SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11546035
107PHF8_20622854_ChIP-Seq_HELA_Human1.10751089
108MAF_26560356_Chip-Seq_TH2_Human1.09958430
109MYC_19030024_ChIP-ChIP_MESCs_Mouse1.09711634
110* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09435842
111* ATF3_27146783_Chip-Seq_COLON_Human1.09377411
112CTCF_21964334_ChIP-Seq_BJAB-B_Human1.09333295
113ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08997596
114RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08785225
115TP63_17297297_ChIP-ChIP_HaCaT_Human1.08402038
116KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08374535
117E2F4_17652178_ChIP-ChIP_JURKAT_Human1.08178439
118* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.07371228
119BCL6_27268052_Chip-Seq_Bcells_Human1.07010034
120CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06840589
121RARB_24833708_ChIP-Seq_LIVER_Mouse1.06134180
122CLOCK_20551151_ChIP-Seq_293T_Human1.06125685
123UBF1/2_26484160_Chip-Seq_HMECs_Human1.04822698
124MYC_19079543_ChIP-ChIP_MESCs_Mouse1.04632206
125GATA1_19941826_ChIP-Seq_K562_Human1.04614586
126* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04386752
127TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03828491
128IRF8_27001747_Chip-Seq_BMDM_Mouse1.03640270
129E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03514384
130DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01775512
131STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.01636574
132IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00328968
133SPI1_23127762_ChIP-Seq_K562_Human0.99461800
134CREB1_26743006_Chip-Seq_LNCaP_Human0.98093345
135VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96121035
136RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.95867693
137MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95520234
138ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94775715
139RARB_27405468_Chip-Seq_BRAIN_Mouse0.93820991
140KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93009128
141MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92436385
142GATA2_19941826_ChIP-Seq_K562_Human0.87787007
143HNF4A_19822575_ChIP-Seq_HepG2_Human0.87659993
144P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87164177
145GATA2_21666600_ChIP-Seq_HMVEC_Human0.86109160
146NFIB_24661679_ChIP-Seq_LUNG_Mouse0.86108897
147SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86090411
148* RACK7_27058665_Chip-Seq_MCF-7_Human0.85310638
149PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83921435
150CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.82203557
151MYB_26560356_Chip-Seq_TH2_Human0.80041363
152CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.79360745
153BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78391264
154NCOR1_26117541_ChIP-Seq_K562_Human0.78293886
155ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.77962430
156CTCF_27219007_Chip-Seq_ERYTHROID_Human0.76548423
157WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.73629743
158TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.71575743
159* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.71177619
160GATA3_27048872_Chip-Seq_THYMUS_Human0.70833081
161VDR_24787735_ChIP-Seq_THP-1_Human0.70381341
162* RUNX1_22412390_ChIP-Seq_EML_Mouse0.69250657
163LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.68946896
164SA1_27219007_Chip-Seq_ERYTHROID_Human0.68050722

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.77879468
2MP0002139_abnormal_hepatobiliary_system5.67681055
3MP0005085_abnormal_gallbladder_physiolo5.02548297
4MP0005365_abnormal_bile_salt4.61077641
5MP0005423_abnormal_somatic_nervous4.02411622
6MP0003123_paternal_imprinting3.62237251
7MP0008875_abnormal_xenobiotic_pharmacok3.34890412
8MP0003252_abnormal_bile_duct3.17793749
9MP0003693_abnormal_embryo_hatching3.04677457
10MP0003303_peritoneal_inflammation2.81450320
11MP0005409_darkened_coat_color2.77552529
12MP0004185_abnormal_adipocyte_glucose2.75967838
13MP0003111_abnormal_nucleus_morphology2.73256471
14MP0005083_abnormal_biliary_tract2.66961231
15MP0010329_abnormal_lipoprotein_level2.66386670
16MP0010030_abnormal_orbit_morphology2.62286070
17MP0002249_abnormal_larynx_morphology2.61873158
18MP0003300_gastrointestinal_ulcer2.41560633
19MP0004233_abnormal_muscle_weight2.26762063
20MP0003942_abnormal_urinary_system2.21108575
21MP0010368_abnormal_lymphatic_system2.15439199
22MP0003077_abnormal_cell_cycle2.13420428
23MP0002822_catalepsy2.10158780
24MP0010094_abnormal_chromosome_stability2.08337364
25MP0003705_abnormal_hypodermis_morpholog2.00261243
26MP0002089_abnormal_postnatal_growth/wei1.88490050
27MP0001800_abnormal_humoral_immune1.88225172
28MP0004957_abnormal_blastocyst_morpholog1.85452208
29MP0000609_abnormal_liver_physiology1.80448566
30MP0001835_abnormal_antigen_presentation1.80024068
31MP0002138_abnormal_hepatobiliary_system1.77386210
32MP0004510_myositis1.77250147
33MP0009840_abnormal_foam_cell1.75735141
34MP0001666_abnormal_nutrient_absorption1.75626532
35MP0003191_abnormal_cellular_cholesterol1.74966198
36MP0005167_abnormal_blood-brain_barrier1.71116663
37MP0003868_abnormal_feces_composition1.70398175
38MP0000569_abnormal_digit_pigmentation1.70204824
39MP0001879_abnormal_lymphatic_vessel1.65429153
40MP0000579_abnormal_nail_morphology1.63173509
41MP0005387_immune_system_phenotype1.61652551
42MP0001790_abnormal_immune_system1.61652551
43MP0009053_abnormal_anal_canal1.59275412
44MP0000778_abnormal_nervous_system1.58767338
45MP0000534_abnormal_ureter_morphology1.55987724
46MP0005410_abnormal_fertilization1.51509546
47MP0000685_abnormal_immune_system1.49157841
48MP0003315_abnormal_perineum_morphology1.44763188
49MP0003436_decreased_susceptibility_to1.43878082
50MP0005332_abnormal_amino_acid1.41932227
51MP0008932_abnormal_embryonic_tissue1.38323085
52MP0002118_abnormal_lipid_homeostasis1.38186678
53MP0003880_abnormal_central_pattern1.37796267
54MP0010307_abnormal_tumor_latency1.36807696
55MP0004859_abnormal_synaptic_plasticity1.35435936
56MP0003861_abnormal_nervous_system1.32923737
57MP0001348_abnormal_lacrimal_gland1.31518384
58MP0008057_abnormal_DNA_replication1.30075769
59MP0000537_abnormal_urethra_morphology1.29638350
60MP0000678_abnormal_parathyroid_gland1.28863019
61MP0001697_abnormal_embryo_size1.27554978
62MP0005666_abnormal_adipose_tissue1.27262543
63MP0008961_abnormal_basal_metabolism1.25066685
64MP0002452_abnormal_antigen_presenting1.23553108
65MP0003122_maternal_imprinting1.23349264
66MP0001730_embryonic_growth_arrest1.20407946
67MP0005319_abnormal_enzyme/_coenzyme1.20394206
68MP0000604_amyloidosis1.18570184
69MP0002092_abnormal_eye_morphology1.18304013
70MP0003121_genomic_imprinting1.18079067
71MP0005584_abnormal_enzyme/coenzyme_acti1.16033452
72MP0002080_prenatal_lethality1.15964924
73MP0002723_abnormal_immune_serum1.14854781
74MP0005380_embryogenesis_phenotype1.13582938
75MP0001672_abnormal_embryogenesis/_devel1.13582938
76MP0002928_abnormal_bile_duct1.12600789
77MP0000350_abnormal_cell_proliferation1.11747240
78MP0005464_abnormal_platelet_physiology1.11450391
79MP0002398_abnormal_bone_marrow1.11009537
80MP0000955_abnormal_spinal_cord1.10921709
81MP0003866_abnormal_defecation1.10749108
82MP0005451_abnormal_body_composition1.10449162
83MP0004808_abnormal_hematopoietic_stem1.09838203
84MP0009278_abnormal_bone_marrow1.09528702
85MP0002085_abnormal_embryonic_tissue1.09114398
86MP0005671_abnormal_response_to1.08420270
87MP0005501_abnormal_skin_physiology1.08375836
88MP0000598_abnormal_liver_morphology1.07294042
89MP0008874_decreased_physiological_sensi1.06926122
90MP0005397_hematopoietic_system_phenotyp1.05569935
91MP0001545_abnormal_hematopoietic_system1.05569935
92MP0004947_skin_inflammation1.04271454
93MP0003115_abnormal_respiratory_system1.03657002
94MP0004381_abnormal_hair_follicle1.03436473
95MP0002420_abnormal_adaptive_immunity1.03031277
96MP0002152_abnormal_brain_morphology1.02443407
97MP0003984_embryonic_growth_retardation1.01637114
98MP0004019_abnormal_vitamin_homeostasis1.00915493
99MP0001346_abnormal_lacrimal_gland1.00876071
100MP0000716_abnormal_immune_system1.00748974
101MP0001819_abnormal_immune_cell1.00505136
102MP0000003_abnormal_adipose_tissue0.99667470
103MP0005000_abnormal_immune_tolerance0.99270451
104MP0005174_abnormal_tail_pigmentation0.99017720
105MP0000733_abnormal_muscle_development0.98987080
106MP0005171_absent_coat_pigmentation0.97021455
107MP0003878_abnormal_ear_physiology0.96803843
108MP0005377_hearing/vestibular/ear_phenot0.96803843
109MP0000313_abnormal_cell_death0.96402923
110MP0000750_abnormal_muscle_regeneration0.96335345
111MP0002088_abnormal_embryonic_growth/wei0.96253610
112MP0005623_abnormal_meninges_morphology0.95683449
113MP0001502_abnormal_circadian_rhythm0.95251311
114MP0010155_abnormal_intestine_physiology0.94589098
115MP0002210_abnormal_sex_determination0.94004006
116MP0004197_abnormal_fetal_growth/weight/0.93315614
117MP0005394_taste/olfaction_phenotype0.93156261
118MP0005499_abnormal_olfactory_system0.93156261
119MP0005375_adipose_tissue_phenotype0.92754392
120MP0009764_decreased_sensitivity_to0.92481236
121MP0005076_abnormal_cell_differentiation0.92479801
122MP0000689_abnormal_spleen_morphology0.91881500
123MP0001849_ear_inflammation0.91839667
124MP0001968_abnormal_touch/_nociception0.91707537
125MP0008007_abnormal_cellular_replicative0.91476330
126MP0008469_abnormal_protein_level0.89778484
127MP0002116_abnormal_craniofacial_bone0.88865751
128MP0002161_abnormal_fertility/fecundity0.88439426
129MP0003698_abnormal_male_reproductive0.87856856
130MP0009785_altered_susceptibility_to0.87819301
131MP0000049_abnormal_middle_ear0.87709725
132MP0009763_increased_sensitivity_to0.87385704
133MP0002081_perinatal_lethality0.87115175
134MP0000751_myopathy0.86667259
135MP0001929_abnormal_gametogenesis0.85832174
136MP0003828_pulmonary_edema0.85296528
137MP0002086_abnormal_extraembryonic_tissu0.84923235
138MP0005025_abnormal_response_to0.84495394
139MP0002429_abnormal_blood_cell0.82820808
140MP0003453_abnormal_keratinocyte_physiol0.82555970
141MP0000566_synostosis0.81145107
142MP0005187_abnormal_penis_morphology0.81103936
143MP0004858_abnormal_nervous_system0.81008100
144MP0000015_abnormal_ear_pigmentation0.80634635
145MP0002084_abnormal_developmental_patter0.79410047
146MP0001845_abnormal_inflammatory_respons0.79040643
147MP0002722_abnormal_immune_system0.78884937
148MP0001293_anophthalmia0.78783526
149MP0000249_abnormal_blood_vessel0.78488538
150MP0004811_abnormal_neuron_physiology0.78149563
151MP0005166_decreased_susceptibility_to0.77947490
152MP0003136_yellow_coat_color0.77399148
153MP0002075_abnormal_coat/hair_pigmentati0.77177646
154MP0002735_abnormal_chemical_nociception0.75432203
155MP0003635_abnormal_synaptic_transmissio0.74484233
156MP0004130_abnormal_muscle_cell0.72073685
157MP0003935_abnormal_craniofacial_develop0.70729883
158MP0003755_abnormal_palate_morphology0.70404975
159MP0009672_abnormal_birth_weight0.70138352
160MP0009931_abnormal_skin_appearance0.70060872
161MP0009642_abnormal_blood_homeostasis0.69758513
162MP0003329_amyloid_beta_deposits0.69739164
163MP0002882_abnormal_neuron_morphology0.69262774
164MP0002419_abnormal_innate_immunity0.68384777
165MP0005448_abnormal_energy_balance0.67428298
166MP0002166_altered_tumor_susceptibility0.67329436
167MP0005535_abnormal_body_temperature0.66981672
168MP0003763_abnormal_thymus_physiology0.66821894
169MP0009643_abnormal_urine_homeostasis0.66734608
170MP0001873_stomach_inflammation0.66147557
171MP0003724_increased_susceptibility_to0.65875659
172MP0004883_abnormal_blood_vessel0.64826425
173MP0002078_abnormal_glucose_homeostasis0.61918368
174MP0002971_abnormal_brown_adipose0.61442242
175MP0002396_abnormal_hematopoietic_system0.61417516
176MP0010630_abnormal_cardiac_muscle0.60234406
177MP0003943_abnormal_hepatobiliary_system0.60146784
178MP0003638_abnormal_response/metabolism_0.58113667
179MP0009765_abnormal_xenobiotic_induced0.58098440
180MP0005334_abnormal_fat_pad0.57404125
181MP0002063_abnormal_learning/memory/cond0.55866719
182MP0000703_abnormal_thymus_morphology0.55499824
183MP0003656_abnormal_erythrocyte_physiolo0.55424848
184MP0004264_abnormal_extraembryonic_tissu0.55157599
185MP0000767_abnormal_smooth_muscle0.54883133
186MP0003091_abnormal_cell_migration0.54841199

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.84155070
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.27670754
3Hypobetalipoproteinemia (HP:0003563)4.11973428
4Hyperlipoproteinemia (HP:0010980)4.10537087
5Facial hemangioma (HP:0000329)4.06706779
6Abnormality of monocarboxylic acid metabolism (HP:0010996)3.92849053
7Intrahepatic cholestasis (HP:0001406)3.71662484
8Prolonged partial thromboplastin time (HP:0003645)3.56443193
9Xanthomatosis (HP:0000991)3.51043550
10Rib fusion (HP:0000902)3.28328807
11Colitis (HP:0002583)3.19443488
12Complement deficiency (HP:0004431)3.17858799
13Panhypogammaglobulinemia (HP:0003139)3.16767693
14Testicular atrophy (HP:0000029)3.07298215
15Chromosomal breakage induced by crosslinking agents (HP:0003221)2.98050412
16Myocardial infarction (HP:0001658)2.96173812
17Poikiloderma (HP:0001029)2.95695783
18Ulnar bowing (HP:0003031)2.92162419
19Esophageal varix (HP:0002040)2.90842932
20Squamous cell carcinoma (HP:0002860)2.90062074
21Spontaneous abortion (HP:0005268)2.88973710
22Agammaglobulinemia (HP:0004432)2.87748760
23Polycythemia (HP:0001901)2.87019294
24Intestinal fistula (HP:0100819)2.86163695
25Epidermoid cyst (HP:0200040)2.79077419
26Thin bony cortex (HP:0002753)2.71283243
27Abnormality of the common coagulation pathway (HP:0010990)2.69353881
28Birth length less than 3rd percentile (HP:0003561)2.65885617
29Turricephaly (HP:0000262)2.65449847
30Akinesia (HP:0002304)2.64187320
31Mitral stenosis (HP:0001718)2.62085327
32Patellar aplasia (HP:0006443)2.61751794
33Joint hemorrhage (HP:0005261)2.60685271
34Aplasia/Hypoplasia of the sacrum (HP:0008517)2.59927594
35Interstitial pulmonary disease (HP:0006530)2.59212512
36Hypolipoproteinemia (HP:0010981)2.58126133
37Vaginal fistula (HP:0004320)2.56926590
38Spastic diplegia (HP:0001264)2.56734394
39Papilloma (HP:0012740)2.55500805
40Verrucae (HP:0200043)2.55500805
41Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.54949771
42Recurrent viral infections (HP:0004429)2.54928064
43Rectovaginal fistula (HP:0000143)2.52358019
44Rectal fistula (HP:0100590)2.52358019
45Insomnia (HP:0100785)2.50978974
46High anterior hairline (HP:0009890)2.50745384
47Fetal akinesia sequence (HP:0001989)2.48104880
48Hyperammonemia (HP:0001987)2.47894328
49Reticulocytopenia (HP:0001896)2.47651208
50Long palpebral fissure (HP:0000637)2.46761967
51Hypercholesterolemia (HP:0003124)2.46690811
52Recurrent gram-negative bacterial infections (HP:0005420)2.43369084
53Aplasia/Hypoplasia of the patella (HP:0006498)2.40528133
54Hypoplasia of the thymus (HP:0000778)2.39597663
55Chromsome breakage (HP:0040012)2.38784643
56Gingival bleeding (HP:0000225)2.34624383
57Annular pancreas (HP:0001734)2.32127856
5811 pairs of ribs (HP:0000878)2.30815830
59Obsessive-compulsive behavior (HP:0000722)2.30226325
60Absent thumb (HP:0009777)2.30058933
61Proximal placement of thumb (HP:0009623)2.28508886
62Abnormality of the thoracic spine (HP:0100711)2.27297622
63Abnormality of glutamine family amino acid metabolism (HP:0010902)2.26486615
64Short thumb (HP:0009778)2.25406507
65Abnormality of pyrimidine metabolism (HP:0004353)2.25260468
66Gastrointestinal infarctions (HP:0005244)2.24716430
67Hemorrhage of the eye (HP:0011885)2.23942063
68Thrombophlebitis (HP:0004418)2.23398017
69Ketosis (HP:0001946)2.23077064
70Progressive muscle weakness (HP:0003323)2.22947481
71Gastrointestinal inflammation (HP:0004386)2.22858446
72Hyperthyroidism (HP:0000836)2.22096848
73Death in childhood (HP:0003819)2.21866714
74Inflammation of the large intestine (HP:0002037)2.20368362
75Acanthocytosis (HP:0001927)2.20328771
76Renal duplication (HP:0000075)2.20081586
77Asymmetry of the thorax (HP:0001555)2.19834997
78Germ cell neoplasia (HP:0100728)2.17446515
79Abnormal delayed hypersensitivity skin test (HP:0002963)2.17379945
80Abnormality of sulfur amino acid metabolism (HP:0004339)2.16949603
81Deep palmar crease (HP:0006191)2.16801321
82Broad distal phalanx of finger (HP:0009836)2.16784577
83Status epilepticus (HP:0002133)2.16324737
84Deviation of the thumb (HP:0009603)2.15014037
85Spina bifida occulta (HP:0003298)2.14979995
86Recurrent sinusitis (HP:0011108)2.11774631
87Increased nuchal translucency (HP:0010880)2.10138291
88Overriding aorta (HP:0002623)2.09329691
89Skin nodule (HP:0200036)2.08677000
90Thyroiditis (HP:0100646)2.07911347
91Recurrent fungal infections (HP:0002841)2.06660557
92Progressive external ophthalmoplegia (HP:0000590)2.06654181
93Patellar dislocation (HP:0002999)2.06553959
94Impaired social interactions (HP:0000735)2.06355036
95Abnormal social behavior (HP:0012433)2.06355036
96Abnormality of complement system (HP:0005339)2.05865992
97Pointed chin (HP:0000307)2.05747288
98Testicular neoplasm (HP:0010788)2.05236099
99Hyperventilation (HP:0002883)2.04821173
100Elfin facies (HP:0004428)2.04684196
101Gastrointestinal stroma tumor (HP:0100723)2.03047531
102Hepatitis (HP:0012115)2.02907195
103Stomatitis (HP:0010280)2.01940732
104Pulmonary embolism (HP:0002204)2.01900044
105Absent radius (HP:0003974)2.00336424
106Menorrhagia (HP:0000132)1.99650218
107Capillary hemangiomas (HP:0005306)1.99643186
108Hyperacusis (HP:0010780)1.99631272
109Macroorchidism (HP:0000053)1.99503917
110Increased mean platelet volume (HP:0011877)1.99205472
111Abnormality of B cell number (HP:0010975)1.98870681
112B lymphocytopenia (HP:0010976)1.98870681
113Abnormality of the fingertips (HP:0001211)1.98674296
114Short chin (HP:0000331)1.97965338
115Septate vagina (HP:0001153)1.97824318
116Hypoalphalipoproteinemia (HP:0003233)1.95854355
117Aplasia of the musculature (HP:0100854)1.95429303
118Lymphangioma (HP:0100764)1.95266872
119Flat acetabular roof (HP:0003180)1.94953065
120Cerebral hemorrhage (HP:0001342)1.92098541
121Abnormal number of incisors (HP:0011064)1.91891437
122Broad face (HP:0000283)1.91784872
123Abnormality of DNA repair (HP:0003254)1.91343032
124Self-mutilation (HP:0000742)1.91164571
125Diastasis recti (HP:0001540)1.91142333
126Cellulitis (HP:0100658)1.90993760
127Arterial thrombosis (HP:0004420)1.89572558
128Duplication of thumb phalanx (HP:0009942)1.89526660
129Abnormality of reticulocytes (HP:0004312)1.89484125
130Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.89430547
131Myokymia (HP:0002411)1.89421773
132Thin ribs (HP:0000883)1.88898250
133Abnormal platelet volume (HP:0011876)1.88083196
134Myopathic facies (HP:0002058)1.87492926
135Viral hepatitis (HP:0006562)1.87467390
136Slender long bone (HP:0003100)1.86727025
137Fatigue (HP:0012378)1.86387020
138Abnormality of the aortic arch (HP:0012303)1.85917103
139Epistaxis (HP:0000421)1.85793256
140Hyperparathyroidism (HP:0000843)1.85574760
141Hypochromic microcytic anemia (HP:0004840)1.85313003
142Heterotopia (HP:0002282)1.84880970
143Impulsivity (HP:0100710)1.84442302
144Breast hypoplasia (HP:0003187)1.83574631
145Reticulocytosis (HP:0001923)1.83435796
146Cerebral aneurysm (HP:0004944)1.82836422
147Cortical dysplasia (HP:0002539)1.81477685
148Choanal stenosis (HP:0000452)1.80955837
149Hepatocellular carcinoma (HP:0001402)1.80310467
150Anteriorly placed anus (HP:0001545)1.79138453
151Autoimmune thrombocytopenia (HP:0001973)1.78790837
152Fair hair (HP:0002286)1.78498997
153Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.78134819
154Poor eye contact (HP:0000817)1.77551308
155Obstructive sleep apnea (HP:0002870)1.77507599
156Aplasia involving forearm bones (HP:0009822)1.76135145
157Absent forearm bone (HP:0003953)1.76135145
158Hemiplegia (HP:0002301)1.76067824
159Hypercortisolism (HP:0001578)1.75886876
160Hematochezia (HP:0002573)1.74558463
161Dysmetric saccades (HP:0000641)1.73810803
162Abnormality of the distal phalanx of the thumb (HP:0009617)1.73551153
163Flattened epiphyses (HP:0003071)1.73169734
164Delayed epiphyseal ossification (HP:0002663)1.73023928
165Impaired platelet aggregation (HP:0003540)1.71812734
166Abnormal platelet function (HP:0011869)1.71812734
167Thoracic kyphosis (HP:0002942)1.71783412
168Stroke (HP:0001297)1.70702848
169Neonatal onset (HP:0003623)1.69155047
170Hypoparathyroidism (HP:0000829)1.68074742
171Recurrent bronchitis (HP:0002837)1.67796942
172Conjunctival telangiectasia (HP:0000524)1.67722023
173Hemangiomatosis (HP:0007461)1.67712895
174Sensorimotor neuropathy (HP:0007141)1.67009376
175Bowel incontinence (HP:0002607)1.66832603
176Poikilocytosis (HP:0004447)1.66366308
177Visceral angiomatosis (HP:0100761)1.66103366
178Preauricular pit (HP:0004467)1.65777577
179Periauricular skin pits (HP:0100277)1.65777577
180Generalized hypotonia (HP:0001290)1.65282568
181Chest pain (HP:0100749)1.64122461
182Partial duplication of thumb phalanx (HP:0009944)1.63718903
183Amyotrophic lateral sclerosis (HP:0007354)1.63688129
184Atresia of the external auditory canal (HP:0000413)1.62992256
185Abnormality of the periventricular white matter (HP:0002518)1.62991865
186Renovascular hypertension (HP:0100817)1.62990063
187Abnormality of chromosome segregation (HP:0002916)1.62862450
188Truncal obesity (HP:0001956)1.62637181
189Male infertility (HP:0003251)1.62323236
190Sparse lateral eyebrow (HP:0005338)1.62185636
191Long toe (HP:0010511)1.61635608
192Abnormality of the phalanges of the hallux (HP:0010057)1.60435670
193Hepatoblastoma (HP:0002884)1.60142364
194Coronal craniosynostosis (HP:0004440)1.59367446

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.83664217
2PRPF4B3.67021610
3ERN13.59141567
4PKN23.41895353
5MAP3K103.07654837
6SMG13.02373022
7RIPK42.94516445
8SIK22.89707164
9IRAK32.55114617
10TRIB32.53754198
11PRKD32.45505575
12FGFR42.29006278
13TAOK12.23015533
14SIK12.20692782
15CDK122.01548069
16GRK61.91324716
17RIPK11.83092501
18TAOK21.83044720
19MAP2K41.80375717
20TLK11.74122151
21IRAK21.67290735
22TESK21.66711622
23MAP3K71.54268973
24ERBB41.53745438
25DAPK21.42544003
26MAP3K91.37635174
27TGFBR21.37425377
28TBK11.36220870
29CDC71.35055158
30MAP3K41.34215602
31SYK1.33129472
32TAOK31.30319958
33CDK71.28999754
34MAP3K131.28416815
35LRRK21.28301090
36CDK191.28031309
37MAPK151.27453236
38MARK11.27394655
39JAK11.24889362
40NME21.24519115
41JAK31.22445423
42TYK21.20570929
43LATS21.15184212
44PTK61.14687890
45RPS6KB21.13077852
46KSR21.12947932
47WNK41.12406943
48KDR1.11712068
49RAF11.10936354
50MAP3K111.10356985
51CHEK21.07206771
52PRKCH1.06444875
53AURKA1.06247993
54FGFR31.02039592
55BRSK11.01796743
56CAMK1G0.99962982
57FLT30.98438097
58CSF1R0.98073186
59ZAP700.97914626
60VRK20.97515974
61PAK60.96823565
62MAPK120.96761119
63ALK0.96034333
64MAP3K140.96028224
65BTK0.93964981
66SIK30.92475050
67STK110.91478979
68CDK11A0.90903609
69STK160.89882550
70PNCK0.89099333
71JAK20.88540650
72MARK20.87512903
73CDK150.87435689
74WEE10.86713991
75MST1R0.86446202
76RET0.84102197
77MARK30.83905017
78ARAF0.81665249
79PDK10.80881329
80FES0.80747723
81CDK90.79617598
82MAPK110.79353618
83CDK180.78718866
84CSK0.77386282
85EPHB10.76593538
86PRKCQ0.76292053
87EEF2K0.74677405
88DMPK0.74433655
89RPS6KC10.73909992
90RPS6KL10.73909992
91SGK30.73007455
92CDK80.72287813
93TGFBR10.72196689
94MAPK40.71411216
95ITK0.71165926
96KSR10.69931210
97STK100.69688427
98CDK140.69599871
99HCK0.69409884
100PRKD20.69066980
101ICK0.68944380
102NEK20.68539859
103MELK0.65907815
104WNK10.64675656
105BRAF0.64386149
106PTK2B0.62352378
107CHEK10.62126097
108EPHA30.61923433
109TAF10.61758843
110CAMKK10.61569517
111RPS6KA60.59894910
112PTK20.59635467
113TYRO30.59194746
114BRD40.59118616
115STK380.57659861
116MAP3K80.56579149
117MAP3K10.54310849
118CDK20.54057160
119MAP2K30.53820558
120CDK10.53680791
121MINK10.53577142
122CAMK1D0.53030485
123RPS6KA10.52916289
124DYRK1B0.52057638
125NTRK10.51550476
126BLK0.51300144
127MAP2K20.50858806
128CDK40.50776905
129ATR0.50758444
130TIE10.50179339
131LCK0.50155394
132DAPK10.49674497
133PRKCZ0.48908441
134NTRK20.47729505
135EGFR0.46777432
136SGK20.46169468
137BCKDK0.46009707
138IKBKB0.45480081
139PDPK10.42987906
140GRK10.41554340
141DYRK1A0.41194467
142PRKAA20.40876923
143CDK50.40575387
144MTOR0.39929537
145EPHA20.39618541
146PRKAA10.39454471
147TTN0.39400902
148IKBKE0.39219189
149CHUK0.39209272
150TESK10.38633018
151MAPK80.38113287
152PAK30.37415134
153PDK20.36578614
154RPS6KA20.36146183
155HIPK20.35986622
156GSK3B0.35932516
157DYRK30.35925339
158PRKCI0.35244872
159ABL10.34488105
160CDC42BPA0.32816866
161ILK0.32659900

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.34325167
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.96410060
3Nitrogen metabolism_Homo sapiens_hsa009103.86558239
4Arginine biosynthesis_Homo sapiens_hsa002203.22726203
5Sulfur relay system_Homo sapiens_hsa041222.78371824
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.64041093
7DNA replication_Homo sapiens_hsa030302.49694467
8Complement and coagulation cascades_Homo sapiens_hsa046102.41972026
9Tryptophan metabolism_Homo sapiens_hsa003802.09146428
10B cell receptor signaling pathway_Homo sapiens_hsa046622.07067002
11Endometrial cancer_Homo sapiens_hsa052131.96575897
12Base excision repair_Homo sapiens_hsa034101.88548451
13Bile secretion_Homo sapiens_hsa049761.88232819
14Cell cycle_Homo sapiens_hsa041101.83852075
15Staphylococcus aureus infection_Homo sapiens_hsa051501.79730102
16Bladder cancer_Homo sapiens_hsa052191.78009339
17Primary immunodeficiency_Homo sapiens_hsa053401.75912261
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.73568074
19Notch signaling pathway_Homo sapiens_hsa043301.71539019
20Lysine degradation_Homo sapiens_hsa003101.71258625
21Butanoate metabolism_Homo sapiens_hsa006501.54659854
22Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.54186589
23Fatty acid degradation_Homo sapiens_hsa000711.53630245
24Basal cell carcinoma_Homo sapiens_hsa052171.50758437
25Fanconi anemia pathway_Homo sapiens_hsa034601.46633383
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.44142039
27Thyroid hormone signaling pathway_Homo sapiens_hsa049191.41302891
28PPAR signaling pathway_Homo sapiens_hsa033201.40564250
29Caffeine metabolism_Homo sapiens_hsa002321.40284549
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.38380003
31Fructose and mannose metabolism_Homo sapiens_hsa000511.34125270
32Alcoholism_Homo sapiens_hsa050341.33206065
33Renal cell carcinoma_Homo sapiens_hsa052111.32736666
34Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.32062898
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.31895194
36Hedgehog signaling pathway_Homo sapiens_hsa043401.31303183
37Hippo signaling pathway_Homo sapiens_hsa043901.26333752
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25667156
39Phenylalanine metabolism_Homo sapiens_hsa003601.23102859
40mRNA surveillance pathway_Homo sapiens_hsa030151.23043083
41Inositol phosphate metabolism_Homo sapiens_hsa005621.20462257
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19290812
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17657912
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.17412441
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.15895688
46Colorectal cancer_Homo sapiens_hsa052101.15108634
47Prostate cancer_Homo sapiens_hsa052151.14881304
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12320744
49ABC transporters_Homo sapiens_hsa020101.11340968
50Thyroid cancer_Homo sapiens_hsa052161.10508956
51Drug metabolism - other enzymes_Homo sapiens_hsa009831.06597528
52beta-Alanine metabolism_Homo sapiens_hsa004101.01931704
53Insulin resistance_Homo sapiens_hsa049311.01356231
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.00814856
55MicroRNAs in cancer_Homo sapiens_hsa052060.99822079
56Axon guidance_Homo sapiens_hsa043600.99696760
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99261578
58Viral carcinogenesis_Homo sapiens_hsa052030.99075255
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.97648168
60T cell receptor signaling pathway_Homo sapiens_hsa046600.96391407
61RNA transport_Homo sapiens_hsa030130.95724058
62Melanogenesis_Homo sapiens_hsa049160.94682130
63Chemical carcinogenesis_Homo sapiens_hsa052040.93137694
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92078295
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.91691032
66Choline metabolism in cancer_Homo sapiens_hsa052310.90818611
67Peroxisome_Homo sapiens_hsa041460.90532097
68Wnt signaling pathway_Homo sapiens_hsa043100.90004184
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89587985
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.88855343
71Nucleotide excision repair_Homo sapiens_hsa034200.88752711
72Cholinergic synapse_Homo sapiens_hsa047250.88618669
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88571783
74Hepatitis B_Homo sapiens_hsa051610.87505182
75Non-small cell lung cancer_Homo sapiens_hsa052230.87034212
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86912799
77Selenocompound metabolism_Homo sapiens_hsa004500.86468374
78Osteoclast differentiation_Homo sapiens_hsa043800.85338377
79Fat digestion and absorption_Homo sapiens_hsa049750.84015670
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.82867282
81Retinol metabolism_Homo sapiens_hsa008300.81220419
82HTLV-I infection_Homo sapiens_hsa051660.81021730
83Endocytosis_Homo sapiens_hsa041440.80412637
84Small cell lung cancer_Homo sapiens_hsa052220.79718903
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79581224
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.79053436
87Mismatch repair_Homo sapiens_hsa034300.76666585
88Other glycan degradation_Homo sapiens_hsa005110.76551257
89VEGF signaling pathway_Homo sapiens_hsa043700.76475670
90Melanoma_Homo sapiens_hsa052180.75547629
91Propanoate metabolism_Homo sapiens_hsa006400.74949390
92Tyrosine metabolism_Homo sapiens_hsa003500.74282875
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.73992605
94Long-term potentiation_Homo sapiens_hsa047200.73901525
95Dorso-ventral axis formation_Homo sapiens_hsa043200.71213257
96Homologous recombination_Homo sapiens_hsa034400.69533466
97MAPK signaling pathway_Homo sapiens_hsa040100.69453744
98Acute myeloid leukemia_Homo sapiens_hsa052210.68569327
99Pyrimidine metabolism_Homo sapiens_hsa002400.68063760
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67750730
101Prolactin signaling pathway_Homo sapiens_hsa049170.67623652
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66600938
103Type II diabetes mellitus_Homo sapiens_hsa049300.66573339
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65370090
105Chronic myeloid leukemia_Homo sapiens_hsa052200.64653605
106Histidine metabolism_Homo sapiens_hsa003400.64192657
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.63846189
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63770134
109FoxO signaling pathway_Homo sapiens_hsa040680.63654332
110Leishmaniasis_Homo sapiens_hsa051400.62834449
111Fatty acid metabolism_Homo sapiens_hsa012120.62281079
112Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60591269
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.60072971
114Glioma_Homo sapiens_hsa052140.59983673
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59876827
116Ribosome_Homo sapiens_hsa030100.59363657
117RNA polymerase_Homo sapiens_hsa030200.57333051
118Estrogen signaling pathway_Homo sapiens_hsa049150.57285008
119Spliceosome_Homo sapiens_hsa030400.56755585
120Toxoplasmosis_Homo sapiens_hsa051450.56534578
121Platelet activation_Homo sapiens_hsa046110.55766135
122Apoptosis_Homo sapiens_hsa042100.54125455
123Epstein-Barr virus infection_Homo sapiens_hsa051690.53885856
124Glycerolipid metabolism_Homo sapiens_hsa005610.52916963
125Chemokine signaling pathway_Homo sapiens_hsa040620.51816345
126Proteoglycans in cancer_Homo sapiens_hsa052050.51532870
127Oocyte meiosis_Homo sapiens_hsa041140.51169546
128ErbB signaling pathway_Homo sapiens_hsa040120.51080461
129TNF signaling pathway_Homo sapiens_hsa046680.50855413
130African trypanosomiasis_Homo sapiens_hsa051430.50638549
131N-Glycan biosynthesis_Homo sapiens_hsa005100.50523813
132Fatty acid biosynthesis_Homo sapiens_hsa000610.49958979
133Systemic lupus erythematosus_Homo sapiens_hsa053220.49834837
134Gap junction_Homo sapiens_hsa045400.49538259
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49196993
136Pentose phosphate pathway_Homo sapiens_hsa000300.49018452
137RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48938583
138Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48882769
139Glucagon signaling pathway_Homo sapiens_hsa049220.48768681
140Cocaine addiction_Homo sapiens_hsa050300.48764616
141Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48317772
142Pancreatic cancer_Homo sapiens_hsa052120.48046961
143Insulin signaling pathway_Homo sapiens_hsa049100.47830941
144Vibrio cholerae infection_Homo sapiens_hsa051100.46984833
145Cyanoamino acid metabolism_Homo sapiens_hsa004600.46622821
146NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46313660
147mTOR signaling pathway_Homo sapiens_hsa041500.45955554
148Renin secretion_Homo sapiens_hsa049240.45876635
149Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45730394
150GnRH signaling pathway_Homo sapiens_hsa049120.44038525
151AMPK signaling pathway_Homo sapiens_hsa041520.42472368
152AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41132356
153Biosynthesis of amino acids_Homo sapiens_hsa012300.39372567
154Oxytocin signaling pathway_Homo sapiens_hsa049210.39349035
155Leukocyte transendothelial migration_Homo sapiens_hsa046700.38301695
156Starch and sucrose metabolism_Homo sapiens_hsa005000.38236411
157Salivary secretion_Homo sapiens_hsa049700.37042260
158Pyruvate metabolism_Homo sapiens_hsa006200.36895327
159Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36690049
160Prion diseases_Homo sapiens_hsa050200.35927137
161Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35732828
162Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35288668
163Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33612838
164Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33306464
165Central carbon metabolism in cancer_Homo sapiens_hsa052300.33196022
166cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32972952
167Gastric acid secretion_Homo sapiens_hsa049710.32550060

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