CA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and proximal renal tubules. Its exact function is not known; however, it may have a role in inherited renal abnormalities of bicarbonate transport. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of respiratory burst (GO:0060267)5.01542981
2glomerular filtration (GO:0003094)4.38866508
3transcytosis (GO:0045056)4.35126184
4sulfate transmembrane transport (GO:1902358)4.16970505
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.03264694
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.90459577
7renal filtration (GO:0097205)3.84404042
8regulation of respiratory burst (GO:0060263)3.79396687
9cGMP-mediated signaling (GO:0019934)3.58966967
10negative regulation of cell killing (GO:0031342)3.54320564
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.54320564
12negative regulation of myotube differentiation (GO:0010832)3.54009148
13antigen processing and presentation of endogenous antigen (GO:0019883)3.53506244
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.52769108
15sperm capacitation (GO:0048240)3.49303342
16respiratory burst (GO:0045730)3.49063507
17ethanol oxidation (GO:0006069)3.40561011
18maintenance of gastrointestinal epithelium (GO:0030277)3.38279792
19positive regulation of Cdc42 GTPase activity (GO:0043089)3.32088208
20positive regulation of fatty acid beta-oxidation (GO:0032000)3.24156287
21sulfate transport (GO:0008272)3.22410483
22intestinal absorption (GO:0050892)3.19415045
23detection of other organism (GO:0098543)3.19365728
24regulation of guanylate cyclase activity (GO:0031282)3.19091097
25positive regulation by symbiont of host defense response (GO:0052509)3.16643609
26modulation by symbiont of host defense response (GO:0052031)3.16643609
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.16643609
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.16643609
29positive regulation by organism of defense response of other organism involved in symbiotic interact3.16643609
30modulation by symbiont of host immune response (GO:0052553)3.16643609
31oligosaccharide biosynthetic process (GO:0009312)3.13072242
32detection of bacterium (GO:0016045)3.05107589
33positive regulation of pseudopodium assembly (GO:0031274)2.98842821
34calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.97439412
35renal system process involved in regulation of blood volume (GO:0001977)2.92311382
36neutrophil activation involved in immune response (GO:0002283)2.88276320
37diacylglycerol metabolic process (GO:0046339)2.84085823
38* bicarbonate transport (GO:0015701)2.83403044
39negative regulation of leukocyte chemotaxis (GO:0002689)2.76555728
40regulation of pseudopodium assembly (GO:0031272)2.76153130
41regulation of intracellular pH (GO:0051453)2.75493179
42regulation of cellular extravasation (GO:0002691)2.74300527
43macrophage activation involved in immune response (GO:0002281)2.72979100
44leukocyte migration involved in inflammatory response (GO:0002523)2.71268969
45neutrophil activation (GO:0042119)2.67509810
46execution phase of apoptosis (GO:0097194)2.67101755
47response to acidic pH (GO:0010447)2.66064163
48sodium ion export (GO:0071436)2.64048464
49creatine metabolic process (GO:0006600)2.63276614
50barbed-end actin filament capping (GO:0051016)2.62804759
51positive regulation of synaptic transmission, GABAergic (GO:0032230)2.62799377
52cellular response to pH (GO:0071467)2.62744166
53regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.61562482
54endocrine process (GO:0050886)2.61562482
55regulation of systemic arterial blood pressure by hormone (GO:0001990)2.61562482
56receptor guanylyl cyclase signaling pathway (GO:0007168)2.61433035
57epithelial structure maintenance (GO:0010669)2.59839578
58detection of external biotic stimulus (GO:0098581)2.58660410
59triglyceride catabolic process (GO:0019433)2.58401409
60pyrimidine-containing compound transmembrane transport (GO:0072531)2.58208515
61cellular response to cAMP (GO:0071320)2.57034553
62superoxide anion generation (GO:0042554)2.52676708
63positive regulation of lipid catabolic process (GO:0050996)2.52590724
64leukocyte aggregation (GO:0070486)2.52292350
65negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.50405715
66positive regulation of fatty acid oxidation (GO:0046321)2.48168761
67neutral lipid catabolic process (GO:0046461)2.48034206
68acylglycerol catabolic process (GO:0046464)2.48034206
69regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.47445570
70NADH metabolic process (GO:0006734)2.47396907
71regulation of cellular pH (GO:0030641)2.47076093
72actin filament polymerization (GO:0030041)2.45115064
73fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.45004983
74ethanol metabolic process (GO:0006067)2.44799290
75nucleoside diphosphate biosynthetic process (GO:0009133)2.43848941
76glucocorticoid biosynthetic process (GO:0006704)2.42106265
77regulation of interferon-beta biosynthetic process (GO:0045357)2.40100945
78regulation of viral entry into host cell (GO:0046596)2.39931960
79regulation of myeloid leukocyte mediated immunity (GO:0002886)2.39224856
80phospholipid homeostasis (GO:0055091)2.38584266
81regulation of T-helper 2 cell differentiation (GO:0045628)2.35934111
82flavonoid metabolic process (GO:0009812)2.35463905
83regulation of regulated secretory pathway (GO:1903305)2.34207153
84bundle of His cell to Purkinje myocyte communication (GO:0086069)2.32169971
85regulation of leukocyte degranulation (GO:0043300)2.31826696
86negative regulation of protein autophosphorylation (GO:0031953)2.31655026
87negative regulation of toll-like receptor signaling pathway (GO:0034122)2.31152604
88granulocyte activation (GO:0036230)2.31117182
89peptidyl-tyrosine autophosphorylation (GO:0038083)2.28431547
90cellular glucuronidation (GO:0052695)2.27251050
91positive regulation of systemic arterial blood pressure (GO:0003084)2.27057384
92sulfur amino acid catabolic process (GO:0000098)2.26501731
93detection of molecule of bacterial origin (GO:0032490)2.24740623
94negative regulation of viral entry into host cell (GO:0046597)2.24387406
95positive regulation of receptor recycling (GO:0001921)2.23686252
96immunoglobulin mediated immune response (GO:0016064)2.20126037
97regulation of somitogenesis (GO:0014807)2.18950784
98positive regulation of guanylate cyclase activity (GO:0031284)2.18164021
99regulation of necrotic cell death (GO:0010939)2.17914109
100regulation of systemic arterial blood pressure (GO:0003073)2.17823546

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.20607988
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.58997362
3* CDX2_20551321_ChIP-Seq_CACO-2_Human2.56568141
4ESR2_21235772_ChIP-Seq_MCF-7_Human2.51058699
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.42697305
6CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.35556565
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.34560098
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.29980612
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.07003836
10DROSHA_22980978_ChIP-Seq_HELA_Human1.95365576
11LXR_22292898_ChIP-Seq_THP-1_Human1.87588704
12SOX2_27498859_Chip-Seq_STOMACH_Mouse1.86778282
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.86355685
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.76262913
15KDM2B_26808549_Chip-Seq_SUP-B15_Human1.75555515
16PPARA_22158963_ChIP-Seq_LIVER_Mouse1.74053633
17TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.70758764
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.68975005
19RXR_22158963_ChIP-Seq_LIVER_Mouse1.68550972
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68143306
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.65305450
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62120467
23* RACK7_27058665_Chip-Seq_MCF-7_Human1.62058510
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.57174608
25FOXO3_23340844_ChIP-Seq_DLD1_Human1.49388695
26SOX2_20726797_ChIP-Seq_SW620_Human1.48185908
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47270965
28PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.46903232
29TCF7_22412390_ChIP-Seq_EML_Mouse1.46445330
30VDR_21846776_ChIP-Seq_THP-1_Human1.45250578
31VDR_24763502_ChIP-Seq_THP-1_Human1.42623910
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39420619
33SPI1_23127762_ChIP-Seq_K562_Human1.37427223
34LXR_22158963_ChIP-Seq_LIVER_Mouse1.36222271
35MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.35204337
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34204069
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32903384
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.29628488
39SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29557936
40NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.27931912
41FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27586140
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26732438
43CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25684664
44* KDM2B_26808549_Chip-Seq_K562_Human1.23791065
45BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.23651726
46GATA1_19941827_ChIP-Seq_MEL_Mouse1.21854643
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21124737
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21066326
49DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20719611
50IRF8_21731497_ChIP-ChIP_J774_Mouse1.20054378
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.17279782
52RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16203370
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.15279428
54KDM2B_26808549_Chip-Seq_DND41_Human1.15181035
55RUNX1_27514584_Chip-Seq_MCF-7_Human1.13707517
56TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11864131
57CLOCK_20551151_ChIP-Seq_293T_Human1.10130886
58LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08999539
59GATA2_21666600_ChIP-Seq_HMVEC_Human1.08613741
60KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08399876
61SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08214243
62GATA1_19941826_ChIP-Seq_K562_Human1.07055521
63GATA4_25053715_ChIP-Seq_YYC3_Human1.05136735
64BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.03538025
65JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.03479077
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03073814
67BCL6_27268052_Chip-Seq_Bcells_Human1.02127969
68SA1_27219007_Chip-Seq_Bcells_Human1.02106152
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01795257
70CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01771483
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00414065
72TP63_17297297_ChIP-ChIP_HaCaT_Human1.00340133
73SMC4_20622854_ChIP-Seq_HELA_Human1.00261568
74GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99586052
75TBX20_22080862_ChIP-Seq_HEART_Mouse0.98788681
76TBX20_22328084_ChIP-Seq_HEART_Mouse0.98788681
77SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98085408
78ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97950065
79Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97725892
80KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97664688
81NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.96404297
82CREB1_26743006_Chip-Seq_LNCaP_Human0.96317416
83BRD4_27068464_Chip-Seq_AML-cells_Mouse0.95498718
84EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95291994
85P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94028924
86PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93921547
87RUNX_20019798_ChIP-Seq_JUKART_Human0.93682903
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93232381
89* GATA6_25053715_ChIP-Seq_YYC3_Human0.93193928
90BCOR_27268052_Chip-Seq_Bcells_Human0.93185949
91SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93185749
92SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92816170
93ERG_21242973_ChIP-ChIP_JURKAT_Human0.92504309
94P68_20966046_ChIP-Seq_HELA_Human0.92388063
95* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92168547
96TET1_21451524_ChIP-Seq_MESCs_Mouse0.92112355
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91679940
98STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.91178269
99SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90892163
100UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.90749616

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.91637325
2MP0002139_abnormal_hepatobiliary_system3.57417848
3MP0010234_abnormal_vibrissa_follicle3.23242584
4MP0003866_abnormal_defecation3.10834742
5MP0003303_peritoneal_inflammation3.00111073
6MP0003191_abnormal_cellular_cholesterol2.96823653
7MP0005670_abnormal_white_adipose2.87486723
8MP0004043_abnormal_pH_regulation2.54038453
9MP0003436_decreased_susceptibility_to2.36972336
10MP0001663_abnormal_digestive_system2.32366699
11MP0010155_abnormal_intestine_physiology2.19168433
12MP0002138_abnormal_hepatobiliary_system2.03623410
13MP0005666_abnormal_adipose_tissue2.02617543
14MP0004264_abnormal_extraembryonic_tissu1.92258469
15MP0001664_abnormal_digestion1.89851205
16MP0005166_decreased_susceptibility_to1.86094054
17MP0005381_digestive/alimentary_phenotyp1.85211745
18MP0005025_abnormal_response_to1.80953218
19MP0009785_altered_susceptibility_to1.71690967
20MP0001765_abnormal_ion_homeostasis1.68826170
21MP0001533_abnormal_skeleton_physiology1.66970291
22MP0003011_delayed_dark_adaptation1.66604856
23MP0002419_abnormal_innate_immunity1.64957129
24MP0003868_abnormal_feces_composition1.62965977
25MP0001873_stomach_inflammation1.61994288
26MP0004130_abnormal_muscle_cell1.61634484
27MP0003705_abnormal_hypodermis_morpholog1.61471844
28MP0003183_abnormal_peptide_metabolism1.57511604
29MP0002971_abnormal_brown_adipose1.55633382
30MP0000477_abnormal_intestine_morphology1.54585863
31MP0005451_abnormal_body_composition1.51160529
32MP0010352_gastrointestinal_tract_polyps1.51016060
33MP0000465_gastrointestinal_hemorrhage1.49651841
34MP0003690_abnormal_glial_cell1.48977596
35MP0005085_abnormal_gallbladder_physiolo1.47268954
36MP0003879_abnormal_hair_cell1.46586985
37MP0003828_pulmonary_edema1.45003322
38MP0003075_altered_response_to1.44575998
39MP0008260_abnormal_autophagy1.43734210
40MP0003300_gastrointestinal_ulcer1.41854241
41MP0005387_immune_system_phenotype1.41755387
42MP0001790_abnormal_immune_system1.41755387
43MP0002132_abnormal_respiratory_system1.41168910
44MP0000490_abnormal_crypts_of1.39169069
45MP0006082_CNS_inflammation1.38333435
46MP0005365_abnormal_bile_salt1.36353177
47MP0005375_adipose_tissue_phenotype1.32994693
48MP0002277_abnormal_respiratory_mucosa1.32739642
49MP0003329_amyloid_beta_deposits1.31501073
50MP0002876_abnormal_thyroid_physiology1.31032571
51MP0004858_abnormal_nervous_system1.28684660
52MP0001800_abnormal_humoral_immune1.24664262
53MP0009840_abnormal_foam_cell1.24295759
54MP0004147_increased_porphyrin_level1.23191601
55MP0008004_abnormal_stomach_pH1.23002721
56MP0005167_abnormal_blood-brain_barrier1.19676167
57MP0010329_abnormal_lipoprotein_level1.16630373
58MP0001501_abnormal_sleep_pattern1.12624193
59MP0009115_abnormal_fat_cell1.12496861
60MP0005409_darkened_coat_color1.11252316
61MP0001819_abnormal_immune_cell1.11180784
62MP0004185_abnormal_adipocyte_glucose1.10333145
63MP0002420_abnormal_adaptive_immunity1.09880183
64MP0002118_abnormal_lipid_homeostasis1.09653343
65MP0005000_abnormal_immune_tolerance1.09576508
66MP0001845_abnormal_inflammatory_respons1.08856332
67MP0004947_skin_inflammation1.07334743
68MP0005636_abnormal_mineral_homeostasis1.06473832
69MP0002723_abnormal_immune_serum1.04970130
70MP0002452_abnormal_antigen_presenting1.04404914
71MP0005535_abnormal_body_temperature1.04225030
72MP0002148_abnormal_hypersensitivity_rea1.04199072
73MP0004484_altered_response_of1.03204327
74MP0003045_fibrosis1.01879377
75MP0004782_abnormal_surfactant_physiolog0.99763991
76MP0001835_abnormal_antigen_presentation0.98135552
77MP0002796_impaired_skin_barrier0.97258252
78MP0001849_ear_inflammation0.97229335
79MP0004510_myositis0.95097027
80MP0005310_abnormal_salivary_gland0.91741868
81MP0002998_abnormal_bone_remodeling0.90586158
82MP0003172_abnormal_lysosome_physiology0.90348258
83MP0000230_abnormal_systemic_arterial0.89183852
84MP0005058_abnormal_lysosome_morphology0.86436821
85MP0000249_abnormal_blood_vessel0.85470422
86MP0005464_abnormal_platelet_physiology0.85387502
87MP0000604_amyloidosis0.85241681
88MP0005165_increased_susceptibility_to0.83269362
89MP0005319_abnormal_enzyme/_coenzyme0.82357728
90MP0002009_preneoplasia0.78092564
91MP0000685_abnormal_immune_system0.76558848
92MP0005584_abnormal_enzyme/coenzyme_acti0.74527109
93MP0001851_eye_inflammation0.74054256
94MP0002166_altered_tumor_susceptibility0.73324246
95MP0002405_respiratory_system_inflammati0.72908825
96MP0005448_abnormal_energy_balance0.71629783
97MP0008874_decreased_physiological_sensi0.70698448
98MP0006138_congestive_heart_failure0.70524012
99MP0005334_abnormal_fat_pad0.70521665
100MP0008469_abnormal_protein_level0.69953135

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)8.09001870
2Metabolic alkalosis (HP:0200114)6.15757082
3Decreased circulating renin level (HP:0003351)6.14773120
4Abnormality of renin-angiotensin system (HP:0000847)5.70984148
5Eczematoid dermatitis (HP:0000976)5.28125314
6Abnormality of chloride homeostasis (HP:0011422)4.38100106
7Hyperaldosteronism (HP:0000859)4.16336123
8Flat acetabular roof (HP:0003180)4.13656807
9Alkalosis (HP:0001948)3.98929364
10Hyponatremia (HP:0002902)3.49689242
11Amyloidosis (HP:0011034)3.27527552
12Hemorrhage of the eye (HP:0011885)3.26336534
13Abnormality of macrophages (HP:0004311)3.20556629
14Recurrent abscess formation (HP:0002722)3.19595646
15Spontaneous hematomas (HP:0007420)3.14796461
16Ileus (HP:0002595)3.00432287
17Right ventricular cardiomyopathy (HP:0011663)3.00153014
18Hypokalemia (HP:0002900)3.00118442
19Visceral angiomatosis (HP:0100761)2.89978282
20Adrenal overactivity (HP:0002717)2.83216348
21Recurrent bacterial skin infections (HP:0005406)2.82953027
22Abnormality of sodium homeostasis (HP:0010931)2.82370802
23Ventricular fibrillation (HP:0001663)2.81454249
24Hyperkalemia (HP:0002153)2.81172718
25Orchitis (HP:0100796)2.78975193
26Myositis (HP:0100614)2.76648612
27Abnormality of monocarboxylic acid metabolism (HP:0010996)2.73169208
28Abnormality of potassium homeostasis (HP:0011042)2.72165825
29Abnormality of the distal phalanx of the thumb (HP:0009617)2.64259472
30Abdominal distention (HP:0003270)2.61527754
31Recurrent gram-negative bacterial infections (HP:0005420)2.59466489
32Flattened epiphyses (HP:0003071)2.55945639
33Polycythemia (HP:0001901)2.53745952
34Ankle clonus (HP:0011448)2.53480270
35Hemangiomatosis (HP:0007461)2.50985659
36Petechiae (HP:0000967)2.44990173
37Segmental peripheral demyelination/remyelination (HP:0003481)2.43666206
38Difficulty running (HP:0009046)2.41728344
39Abnormal vertebral ossification (HP:0100569)2.37635318
40Gastrointestinal infarctions (HP:0005244)2.36887762
41Syncope (HP:0001279)2.34869220
42Hypertriglyceridemia (HP:0002155)2.31160345
43Malnutrition (HP:0004395)2.30898268
44Growth hormone excess (HP:0000845)2.30894540
45Gingivitis (HP:0000230)2.30392891
46Abnormal tarsal ossification (HP:0008369)2.28897409
47Inflammation of the large intestine (HP:0002037)2.19947794
48Colitis (HP:0002583)2.19360848
49Systemic lupus erythematosus (HP:0002725)2.18028207
50Retrobulbar optic neuritis (HP:0100654)2.17770642
51Optic neuritis (HP:0100653)2.17770642
52Flat capital femoral epiphysis (HP:0003370)2.15551744
53Spinal cord compression (HP:0002176)2.12858913
54Gastrointestinal inflammation (HP:0004386)2.08724758
55Urticaria (HP:0001025)2.07322315
56Bundle branch block (HP:0011710)2.07217527
57Neonatal short-limb short stature (HP:0008921)2.05445597
58Toxemia of pregnancy (HP:0100603)1.99832427
59Premature loss of primary teeth (HP:0006323)1.99520793
60Hypochromic microcytic anemia (HP:0004840)1.97863664
61Muscle fiber splitting (HP:0003555)1.96481516
62Cellulitis (HP:0100658)1.96291688
63Vertebral clefting (HP:0008428)1.93000226
64Elevated erythrocyte sedimentation rate (HP:0003565)1.92613491
65Intrahepatic cholestasis (HP:0001406)1.92016832
66Abnormality of carpal bone ossification (HP:0006257)1.87463778
67Chronic obstructive pulmonary disease (HP:0006510)1.87347130
68Obstructive lung disease (HP:0006536)1.87347130
69Axonal loss (HP:0003447)1.86254954
70Ventricular arrhythmia (HP:0004308)1.85649070
71Increased connective tissue (HP:0009025)1.83442511
72Mediastinal lymphadenopathy (HP:0100721)1.83021426
73Keratoconjunctivitis sicca (HP:0001097)1.80822965
74Meningitis (HP:0001287)1.79768281
75Hypochromic anemia (HP:0001931)1.77678724
76Increased variability in muscle fiber diameter (HP:0003557)1.77232497
77Increased IgE level (HP:0003212)1.76029044
78Centrally nucleated skeletal muscle fibers (HP:0003687)1.75228984
79Gastrointestinal dysmotility (HP:0002579)1.74955881
80Vasculitis (HP:0002633)1.74873812
81Abnormality of skeletal muscle fiber size (HP:0012084)1.74873081
82Oligomenorrhea (HP:0000876)1.74236376
83Hemoptysis (HP:0002105)1.74089762
84Hyporeflexia of lower limbs (HP:0002600)1.73168076
85Gingival bleeding (HP:0000225)1.73069208
86Hepatosplenomegaly (HP:0001433)1.73003302
87Osteomyelitis (HP:0002754)1.68943752
88Hyperparathyroidism (HP:0000843)1.68378498
89Stomatitis (HP:0010280)1.66759332
90Abnormality of the nasal mucosa (HP:0000433)1.66716083
91Prolonged bleeding time (HP:0003010)1.62768046
92Polygenic inheritance (HP:0010982)1.61744105
93Distal lower limb muscle weakness (HP:0009053)1.61349849
94Microcytic anemia (HP:0001935)1.60869359
95Distal lower limb amyotrophy (HP:0008944)1.60307404
96Abnormality of the 1st metacarpal (HP:0010009)1.59531885
97Hematochezia (HP:0002573)1.58926852
98Breech presentation (HP:0001623)1.58697389
99Dehydration (HP:0001944)1.58171293
100Chest pain (HP:0100749)1.58037564

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK14.21345193
2PIK3CA3.99402387
3RIPK43.98719340
4ERN13.38127520
5LMTK22.99063385
6EPHA22.40205817
7ACVR1B2.40079325
8MST1R2.12062623
9EPHB11.90672927
10MAP2K31.77609964
11IRAK41.77244080
12CSK1.69882099
13PRPF4B1.68057895
14KSR21.67412810
15TAOK11.66441445
16PTK61.64470507
17TRIB31.60572929
18TYK21.59737373
19MAP4K11.56675065
20PDPK11.55617930
21ZAP701.46500186
22MAP3K111.44582808
23TNK21.44579630
24GRK61.42776401
25FES1.42577344
26DAPK21.42454124
27EPHB21.36832097
28PRKG21.36463749
29MAP3K11.28646762
30EPHA41.26670192
31PDK11.21258282
32CDK191.20519787
33JAK21.11060513
34BLK1.04511500
35SIK31.03886684
36MAP3K20.98865565
37FGFR40.97383992
38TESK10.97369143
39SIK10.95811315
40OXSR10.93500195
41TESK20.92844905
42DMPK0.92827957
43MAP2K60.92429248
44MAP3K30.91310204
45SMG10.88143574
46PRKD20.87775572
47MAP3K60.87134635
48MAP2K20.85419417
49MARK20.84901789
50HCK0.80717070
51PRKAA20.77591002
52PDK20.77430674
53FGR0.75135354
54MAPK120.75065234
55NTRK30.73529009
56MAP3K120.72444184
57MAP2K40.71602454
58TBK10.70547587
59YES10.70198398
60CDC42BPA0.69209838
61RET0.65027284
62MAP3K130.65009306
63STK380.63413915
64ABL20.62860740
65JAK10.61728944
66STK240.60490311
67GRK50.59796101
68LYN0.58602117
69MYLK0.57414826
70FYN0.54713149
71CAMK10.53089439
72STK110.52567274
73ARAF0.51949707
74EPHA30.51355772
75CAMKK10.50509543
76IKBKE0.50497200
77SYK0.50057195
78MAP2K10.49681120
79FGFR30.48750510
80CAMK2D0.48074464
81LRRK20.47992208
82MATK0.46714861
83PAK60.45815213
84JAK30.45039784
85TAOK20.44913841
86BTK0.43909545
87DYRK1B0.43752732
88TIE10.43496748
89PRKCZ0.43366739
90IRAK10.42984771
91STK390.42056079
92DDR20.40514758
93MAPK70.40441748
94MET0.40269683
95IRAK20.40018096
96SGK30.39378592
97FER0.38922241
98PRKD10.37913133
99TTN0.33144434
100SRC0.32771811

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009203.86317513
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.80003473
3Cyanoamino acid metabolism_Homo sapiens_hsa004602.34352226
4* Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.30952792
5* Nitrogen metabolism_Homo sapiens_hsa009102.22789034
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.15528263
7PPAR signaling pathway_Homo sapiens_hsa033201.94879823
8Mineral absorption_Homo sapiens_hsa049781.81043680
9Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.76610729
10Pancreatic secretion_Homo sapiens_hsa049721.59373663
11Leukocyte transendothelial migration_Homo sapiens_hsa046701.56748902
12Fat digestion and absorption_Homo sapiens_hsa049751.53158065
13Osteoclast differentiation_Homo sapiens_hsa043801.48233978
14Fatty acid degradation_Homo sapiens_hsa000711.47536070
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.45199013
16Staphylococcus aureus infection_Homo sapiens_hsa051501.39306714
17Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.38788080
18Histidine metabolism_Homo sapiens_hsa003401.38247325
19Bile secretion_Homo sapiens_hsa049761.37930016
20Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.33121987
21Leishmaniasis_Homo sapiens_hsa051401.28527198
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.26593624
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.24513586
24Other glycan degradation_Homo sapiens_hsa005111.21113640
25Arginine biosynthesis_Homo sapiens_hsa002201.11778940
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06130714
27Glycerolipid metabolism_Homo sapiens_hsa005611.01319618
28Hepatitis C_Homo sapiens_hsa051601.00266581
29Tuberculosis_Homo sapiens_hsa051520.97010342
30Renin secretion_Homo sapiens_hsa049240.95413201
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92546171
32Gastric acid secretion_Homo sapiens_hsa049710.90354749
33African trypanosomiasis_Homo sapiens_hsa051430.88068990
34Adipocytokine signaling pathway_Homo sapiens_hsa049200.87614406
35GnRH signaling pathway_Homo sapiens_hsa049120.87187260
36Chemokine signaling pathway_Homo sapiens_hsa040620.86453744
37Long-term potentiation_Homo sapiens_hsa047200.86190623
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84788280
39Fructose and mannose metabolism_Homo sapiens_hsa000510.84491025
40Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82141736
41Glycerophospholipid metabolism_Homo sapiens_hsa005640.73192271
42Caffeine metabolism_Homo sapiens_hsa002320.72970097
43Acute myeloid leukemia_Homo sapiens_hsa052210.72847740
44Retinol metabolism_Homo sapiens_hsa008300.72684498
45Starch and sucrose metabolism_Homo sapiens_hsa005000.72662004
46Drug metabolism - other enzymes_Homo sapiens_hsa009830.70808600
47B cell receptor signaling pathway_Homo sapiens_hsa046620.68864146
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.68672618
49Tight junction_Homo sapiens_hsa045300.68295768
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63987433
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63453233
52VEGF signaling pathway_Homo sapiens_hsa043700.62722336
53Salmonella infection_Homo sapiens_hsa051320.62449995
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62216837
55Endocytosis_Homo sapiens_hsa041440.61285087
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61126842
57Sulfur relay system_Homo sapiens_hsa041220.60157714
58Synaptic vesicle cycle_Homo sapiens_hsa047210.59322303
59Insulin signaling pathway_Homo sapiens_hsa049100.58882282
60Malaria_Homo sapiens_hsa051440.58834596
61Pertussis_Homo sapiens_hsa051330.58548988
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57623857
63Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57131072
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55912861
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54703866
66Galactose metabolism_Homo sapiens_hsa000520.54617522
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54305206
68Insulin resistance_Homo sapiens_hsa049310.53817646
69Arginine and proline metabolism_Homo sapiens_hsa003300.51361290
70Graft-versus-host disease_Homo sapiens_hsa053320.50822043
71Platelet activation_Homo sapiens_hsa046110.50674521
72Choline metabolism in cancer_Homo sapiens_hsa052310.50612830
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50464440
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50340257
75Fatty acid metabolism_Homo sapiens_hsa012120.50261550
76Toxoplasmosis_Homo sapiens_hsa051450.49675941
77HIF-1 signaling pathway_Homo sapiens_hsa040660.49437074
78Phagosome_Homo sapiens_hsa041450.49365042
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.48770155
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48527563
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47937161
82Allograft rejection_Homo sapiens_hsa053300.46422477
83AMPK signaling pathway_Homo sapiens_hsa041520.45252818
84Amoebiasis_Homo sapiens_hsa051460.44693720
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43603294
86Inositol phosphate metabolism_Homo sapiens_hsa005620.43516462
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42346010
88Autoimmune thyroid disease_Homo sapiens_hsa053200.42342132
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41724952
90TNF signaling pathway_Homo sapiens_hsa046680.40181698
91Phenylalanine metabolism_Homo sapiens_hsa003600.39608309
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39454855
93Influenza A_Homo sapiens_hsa051640.38482372
94cAMP signaling pathway_Homo sapiens_hsa040240.37391316
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.36572098
96Collecting duct acid secretion_Homo sapiens_hsa049660.36210985
97Rap1 signaling pathway_Homo sapiens_hsa040150.36088508
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35140019
99Estrogen signaling pathway_Homo sapiens_hsa049150.35096145
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34228261

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