C9ORF85

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.95960654
2fucose catabolic process (GO:0019317)4.41713078
3L-fucose metabolic process (GO:0042354)4.41713078
4L-fucose catabolic process (GO:0042355)4.41713078
5DNA deamination (GO:0045006)4.30215918
6water-soluble vitamin biosynthetic process (GO:0042364)4.17414051
7protein complex biogenesis (GO:0070271)3.92640965
8mitochondrial respiratory chain complex I assembly (GO:0032981)3.78999757
9NADH dehydrogenase complex assembly (GO:0010257)3.78999757
10mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.78999757
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.74276660
12establishment of protein localization to mitochondrial membrane (GO:0090151)3.69898026
13mitochondrial respiratory chain complex assembly (GO:0033108)3.69035559
14respiratory chain complex IV assembly (GO:0008535)3.59036502
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.59019261
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.57630828
17energy coupled proton transport, down electrochemical gradient (GO:0015985)3.52338890
18ATP synthesis coupled proton transport (GO:0015986)3.52338890
19kynurenine metabolic process (GO:0070189)3.43938832
20platelet dense granule organization (GO:0060155)3.42001027
21protein-cofactor linkage (GO:0018065)3.40865374
22negative regulation of telomere maintenance (GO:0032205)3.33648681
23protein neddylation (GO:0045116)3.30409252
24maturation of 5.8S rRNA (GO:0000460)3.30110267
25cellular ketone body metabolic process (GO:0046950)3.29390791
26tryptophan catabolic process (GO:0006569)3.29376317
27indole-containing compound catabolic process (GO:0042436)3.29376317
28indolalkylamine catabolic process (GO:0046218)3.29376317
29indolalkylamine metabolic process (GO:0006586)3.28153365
30detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.25448422
31cytochrome complex assembly (GO:0017004)3.24491307
32detection of light stimulus involved in visual perception (GO:0050908)3.23701124
33detection of light stimulus involved in sensory perception (GO:0050962)3.23701124
34nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.07746597
35epithelial cilium movement (GO:0003351)3.04801816
36tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.00133312
37RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.00133312
38exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.99804522
39response to pheromone (GO:0019236)2.98587206
40ketone body metabolic process (GO:1902224)2.97228615
41regulation of cilium movement (GO:0003352)2.95999486
42pseudouridine synthesis (GO:0001522)2.95015023
43electron transport chain (GO:0022900)2.93461139
44piRNA metabolic process (GO:0034587)2.93257195
45intracellular protein transmembrane import (GO:0044743)2.91074913
46DNA double-strand break processing (GO:0000729)2.90109005
47respiratory electron transport chain (GO:0022904)2.87699473
48protein polyglutamylation (GO:0018095)2.87567958
49regulation of nuclear cell cycle DNA replication (GO:0033262)2.86613909
50behavioral response to ethanol (GO:0048149)2.86389998
51nonmotile primary cilium assembly (GO:0035058)2.81799113
52tryptophan metabolic process (GO:0006568)2.81443734
53sulfation (GO:0051923)2.81421299
54preassembly of GPI anchor in ER membrane (GO:0016254)2.78919739
55replication fork processing (GO:0031297)2.78849222
56ubiquinone biosynthetic process (GO:0006744)2.77499109
57transcription elongation from RNA polymerase III promoter (GO:0006385)2.75158221
58termination of RNA polymerase III transcription (GO:0006386)2.75158221
59negative regulation of DNA-dependent DNA replication (GO:2000104)2.72174826
60kidney morphogenesis (GO:0060993)2.70828517
61recombinational repair (GO:0000725)2.69361119
62mannosylation (GO:0097502)2.68120698
63double-strand break repair via homologous recombination (GO:0000724)2.67654201
64negative regulation of mast cell activation (GO:0033004)2.67263022
65cilium morphogenesis (GO:0060271)2.65520627
66axoneme assembly (GO:0035082)2.64965640
67ubiquinone metabolic process (GO:0006743)2.64408875
68cytidine metabolic process (GO:0046087)2.64004140
69cytidine catabolic process (GO:0006216)2.64004140
70cytidine deamination (GO:0009972)2.64004140
71intraciliary transport (GO:0042073)2.61709229
72amine catabolic process (GO:0009310)2.61631108
73cellular biogenic amine catabolic process (GO:0042402)2.61631108
74rRNA catabolic process (GO:0016075)2.61518971
75proteasome assembly (GO:0043248)2.59625131
76base-excision repair, AP site formation (GO:0006285)2.58333507
77photoreceptor cell development (GO:0042461)2.58149685
78reciprocal DNA recombination (GO:0035825)2.57739866
79reciprocal meiotic recombination (GO:0007131)2.57739866
80tRNA processing (GO:0008033)2.56576865
81synapsis (GO:0007129)2.55697433
82rhodopsin mediated signaling pathway (GO:0016056)2.55261671
83regulation of rhodopsin mediated signaling pathway (GO:0022400)2.54813488
84dopamine transport (GO:0015872)2.54581239
85signal peptide processing (GO:0006465)2.54228102
86cilium organization (GO:0044782)2.52715849
87protein K6-linked ubiquitination (GO:0085020)2.51598572
88protein prenylation (GO:0018342)2.51200896
89prenylation (GO:0097354)2.51200896
90protein localization to cilium (GO:0061512)2.50754011
91chaperone-mediated protein transport (GO:0072321)2.49343225
92neural tube formation (GO:0001841)2.47115503
93RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.46605059
94L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.46258699
95regulation of hexokinase activity (GO:1903299)2.46074149
96regulation of glucokinase activity (GO:0033131)2.46074149
97retinal cone cell development (GO:0046549)2.45503139
98male meiosis I (GO:0007141)2.45421901
99regulation of mesoderm development (GO:2000380)2.44609095
100cilium assembly (GO:0042384)2.43967164

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.07000795
2VDR_22108803_ChIP-Seq_LS180_Human3.44212533
3* GABP_17652178_ChIP-ChIP_JURKAT_Human2.73723473
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.72265052
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.69813724
6EZH2_22144423_ChIP-Seq_EOC_Human2.57588845
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.54510418
8GBX2_23144817_ChIP-Seq_PC3_Human2.44652149
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38764933
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.36653887
11EWS_26573619_Chip-Seq_HEK293_Human2.25900466
12IGF1R_20145208_ChIP-Seq_DFB_Human2.25792808
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.24508368
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.22850791
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.20762436
16FUS_26573619_Chip-Seq_HEK293_Human2.16583111
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.07774032
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99423680
19P300_19829295_ChIP-Seq_ESCs_Human1.98059660
20* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93633762
21ELK1_19687146_ChIP-ChIP_HELA_Human1.91594156
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.89911246
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83245355
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83165085
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.80670102
26TAF15_26573619_Chip-Seq_HEK293_Human1.79967983
27IRF1_19129219_ChIP-ChIP_H3396_Human1.76277102
28ER_23166858_ChIP-Seq_MCF-7_Human1.75720141
29MYC_18940864_ChIP-ChIP_HL60_Human1.74074738
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71444799
31VDR_23849224_ChIP-Seq_CD4+_Human1.67981731
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.67196237
33MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.65408280
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.64004277
35TP53_22573176_ChIP-Seq_HFKS_Human1.59648615
36ETS1_20019798_ChIP-Seq_JURKAT_Human1.55432418
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45771626
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44058987
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43753613
40BCAT_22108803_ChIP-Seq_LS180_Human1.43029072
41* SOX2_19829295_ChIP-Seq_ESCs_Human1.40475652
42* NANOG_19829295_ChIP-Seq_ESCs_Human1.40475652
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.38314528
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.37756075
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.37756075
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37078985
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36192758
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35818609
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31139763
50CBP_20019798_ChIP-Seq_JUKART_Human1.31139763
51STAT3_23295773_ChIP-Seq_U87_Human1.30504839
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28942049
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.28791268
54AR_25329375_ChIP-Seq_VCAP_Human1.27007356
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.26710870
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.25837323
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.24771032
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.24209665
59AR_20517297_ChIP-Seq_VCAP_Human1.23303339
60TCF4_22108803_ChIP-Seq_LS180_Human1.23178043
61SMAD4_21799915_ChIP-Seq_A2780_Human1.22631520
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21436053
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21316903
64NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20881718
65TCF4_23295773_ChIP-Seq_U87_Human1.18902794
66RNF2_27304074_Chip-Seq_NSC_Mouse1.18622829
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18108217
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.18030040
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17736764
70FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15547652
71NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14572285
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14320851
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14071082
74FOXP3_21729870_ChIP-Seq_TREG_Human1.13942105
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12178611
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11464661
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11123096
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11123096
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10807946
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.09540831
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09492733
82EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07825431
83NCOR_22424771_ChIP-Seq_293T_Human1.07514619
84HOXB7_26014856_ChIP-Seq_BT474_Human1.07093888
85ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06501023
86CRX_20693478_ChIP-Seq_RETINA_Mouse1.06382499
87CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.05695418
88EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04622018
89RUNX2_22187159_ChIP-Seq_PCA_Human1.02209321
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01683525
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00966846
92CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00542621
93SMAD4_21741376_ChIP-Seq_EPCs_Human1.00423068
94FLI1_21867929_ChIP-Seq_TH2_Mouse0.99642697
95AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99492357
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98062408
97PRDM14_20953172_ChIP-Seq_ESCs_Human0.96622999
98PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96463540
99P53_22387025_ChIP-Seq_ESCs_Mouse0.96103268
100E2F4_17652178_ChIP-ChIP_JURKAT_Human0.95443045

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis2.90556948
2MP0006292_abnormal_olfactory_placode2.62313214
3MP0003136_yellow_coat_color2.59492860
4MP0002102_abnormal_ear_morphology2.54895269
5MP0008877_abnormal_DNA_methylation2.52444722
6MP0003646_muscle_fatigue2.51111979
7MP0005551_abnormal_eye_electrophysiolog2.48603590
8MP0002837_dystrophic_cardiac_calcinosis2.48280239
9MP0004147_increased_porphyrin_level2.26468317
10MP0001986_abnormal_taste_sensitivity2.12939001
11MP0006072_abnormal_retinal_apoptosis2.09980647
12MP0004142_abnormal_muscle_tone2.06940271
13MP0002938_white_spotting2.03885497
14MP0000569_abnormal_digit_pigmentation2.00716738
15MP0003011_delayed_dark_adaptation1.99113236
16MP0005084_abnormal_gallbladder_morpholo1.93847264
17MP0001529_abnormal_vocalization1.87641641
18MP0005253_abnormal_eye_physiology1.78476603
19MP0000372_irregular_coat_pigmentation1.77377481
20MP0001485_abnormal_pinna_reflex1.76461387
21MP0001968_abnormal_touch/_nociception1.76130835
22MP0008875_abnormal_xenobiotic_pharmacok1.74700531
23MP0008872_abnormal_physiological_respon1.74005134
24MP0002638_abnormal_pupillary_reflex1.73313037
25MP0005645_abnormal_hypothalamus_physiol1.72020197
26MP0002876_abnormal_thyroid_physiology1.68823745
27MP0009379_abnormal_foot_pigmentation1.68162271
28MP0002736_abnormal_nociception_after1.67894961
29MP0009046_muscle_twitch1.64750023
30MP0004885_abnormal_endolymph1.60252584
31MP0005174_abnormal_tail_pigmentation1.59994610
32MP0006276_abnormal_autonomic_nervous1.59112988
33MP0003718_maternal_effect1.56522667
34MP0008058_abnormal_DNA_repair1.51471937
35MP0003880_abnormal_central_pattern1.49666535
36MP0009745_abnormal_behavioral_response1.49215703
37MP0003890_abnormal_embryonic-extraembry1.48265352
38MP0000427_abnormal_hair_cycle1.45877143
39MP0002160_abnormal_reproductive_system1.45535950
40MP0004145_abnormal_muscle_electrophysio1.44715836
41MP0005646_abnormal_pituitary_gland1.41885729
42MP0002272_abnormal_nervous_system1.39008738
43MP0005389_reproductive_system_phenotype1.37498134
44MP0004133_heterotaxia1.37364954
45MP0002163_abnormal_gland_morphology1.35508958
46MP0002653_abnormal_ependyma_morphology1.34920703
47MP0002095_abnormal_skin_pigmentation1.32304211
48MP0001486_abnormal_startle_reflex1.29635991
49MP0001293_anophthalmia1.29224221
50MP0001984_abnormal_olfaction1.27510979
51MP0004043_abnormal_pH_regulation1.25953876
52MP0000631_abnormal_neuroendocrine_gland1.22332448
53MP0002277_abnormal_respiratory_mucosa1.21142925
54MP0002234_abnormal_pharynx_morphology1.18910971
55MP0004215_abnormal_myocardial_fiber1.18246038
56MP0001501_abnormal_sleep_pattern1.16066107
57MP0005195_abnormal_posterior_eye1.14840459
58MP0002928_abnormal_bile_duct1.14636249
59MP0004742_abnormal_vestibular_system1.14342475
60MP0001919_abnormal_reproductive_system1.09590006
61MP0005410_abnormal_fertilization1.09150651
62MP0002735_abnormal_chemical_nociception1.08941845
63MP0002557_abnormal_social/conspecific_i1.05646164
64MP0008789_abnormal_olfactory_epithelium1.04386545
65MP0005377_hearing/vestibular/ear_phenot1.03007329
66MP0003878_abnormal_ear_physiology1.03007329
67MP0005379_endocrine/exocrine_gland_phen1.01301107
68MP0005075_abnormal_melanosome_morpholog1.00658756
69MP0005171_absent_coat_pigmentation1.00197148
70MP0001324_abnormal_eye_pigmentation0.99070312
71MP0003137_abnormal_impulse_conducting0.97969293
72MP0005085_abnormal_gallbladder_physiolo0.97683057
73MP0001905_abnormal_dopamine_level0.96453315
74MP0002751_abnormal_autonomic_nervous0.96225939
75MP0002733_abnormal_thermal_nociception0.95731154
76MP0004924_abnormal_behavior0.95458374
77MP0005386_behavior/neurological_phenoty0.95458374
78MP0002067_abnormal_sensory_capabilities0.95320067
79MP0001970_abnormal_pain_threshold0.93300091
80MP0000383_abnormal_hair_follicle0.93038343
81MP0002752_abnormal_somatic_nervous0.90303227
82MP0002210_abnormal_sex_determination0.89949197
83MP0003567_abnormal_fetal_cardiomyocyte0.88514211
84MP0003186_abnormal_redox_activity0.88132727
85MP0002572_abnormal_emotion/affect_behav0.87406899
86MP0002138_abnormal_hepatobiliary_system0.86983964
87MP0000647_abnormal_sebaceous_gland0.86808205
88MP0008775_abnormal_heart_ventricle0.86762348
89MP0002254_reproductive_system_inflammat0.85556289
90MP0008995_early_reproductive_senescence0.83916188
91MP0003698_abnormal_male_reproductive0.82801989
92MP0001929_abnormal_gametogenesis0.82257465
93MP0005423_abnormal_somatic_nervous0.82211023
94MP0003950_abnormal_plasma_membrane0.82064593
95MP0003119_abnormal_digestive_system0.81749978
96MP0002064_seizures0.81452482
97MP0001764_abnormal_homeostasis0.80327290
98MP0003937_abnormal_limbs/digits/tail_de0.79948704
99MP0003787_abnormal_imprinting0.79934922
100MP0000026_abnormal_inner_ear0.79461870

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.38015523
2Abnormality of midbrain morphology (HP:0002418)4.14374677
3Molar tooth sign on MRI (HP:0002419)4.14374677
4Pancreatic fibrosis (HP:0100732)3.91510412
5True hermaphroditism (HP:0010459)3.76445169
6Congenital stationary night blindness (HP:0007642)3.65589022
7Nephronophthisis (HP:0000090)3.42823965
8Type II lissencephaly (HP:0007260)3.40275765
9Acute necrotizing encephalopathy (HP:0006965)3.20840814
10Medial flaring of the eyebrow (HP:0010747)3.04204524
11Mitochondrial inheritance (HP:0001427)2.98541458
12Abnormality of the renal medulla (HP:0100957)2.97550416
13Abnormality of the renal cortex (HP:0011035)2.93675964
14Increased CSF lactate (HP:0002490)2.89461672
15Acute encephalopathy (HP:0006846)2.85098542
16Abolished electroretinogram (ERG) (HP:0000550)2.84976708
17Congenital, generalized hypertrichosis (HP:0004540)2.79216082
18Birth length less than 3rd percentile (HP:0003561)2.74213442
19Abnormal mitochondria in muscle tissue (HP:0008316)2.73745800
20Progressive macrocephaly (HP:0004481)2.73198509
21Lipid accumulation in hepatocytes (HP:0006561)2.67460473
22Attenuation of retinal blood vessels (HP:0007843)2.66753126
23Increased hepatocellular lipid droplets (HP:0006565)2.65057050
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.62094437
25Abnormality of alanine metabolism (HP:0010916)2.62094437
26Hyperalaninemia (HP:0003348)2.62094437
27Inability to walk (HP:0002540)2.58974819
28Sclerocornea (HP:0000647)2.49170099
29Hyperventilation (HP:0002883)2.47213082
303-Methylglutaconic aciduria (HP:0003535)2.45878210
31Pendular nystagmus (HP:0012043)2.45342821
32Gait imbalance (HP:0002141)2.43616122
33Hepatocellular necrosis (HP:0001404)2.42208956
34Cystic liver disease (HP:0006706)2.41937115
35Renal cortical cysts (HP:0000803)2.41749868
36Abnormality of the pons (HP:0007361)2.41550915
37Abnormal rod and cone electroretinograms (HP:0008323)2.39525550
38Congenital primary aphakia (HP:0007707)2.39042111
39Methylmalonic acidemia (HP:0002912)2.38167346
40Cerebellar dysplasia (HP:0007033)2.33255613
41Tubular atrophy (HP:0000092)2.32383549
42Hypoplasia of the pons (HP:0012110)2.31440163
43Hepatic necrosis (HP:0002605)2.30307734
44Progressive inability to walk (HP:0002505)2.28836375
45Aplasia/Hypoplasia of the tongue (HP:0010295)2.28621655
46Aplasia/Hypoplasia of the tibia (HP:0005772)2.24106437
47Polydipsia (HP:0001959)2.23014848
48Abnormal drinking behavior (HP:0030082)2.23014848
49Chronic hepatic failure (HP:0100626)2.21683504
50Nephrogenic diabetes insipidus (HP:0009806)2.21028935
51Large for gestational age (HP:0001520)2.19245701
52Optic disc pallor (HP:0000543)2.17337093
53Abnormal number of erythroid precursors (HP:0012131)2.16276008
54Concave nail (HP:0001598)2.15856535
55Abnormal biliary tract physiology (HP:0012439)2.15317296
56Bile duct proliferation (HP:0001408)2.15317296
57Furrowed tongue (HP:0000221)2.14832492
58Colon cancer (HP:0003003)2.13564134
59Anencephaly (HP:0002323)2.10783742
60Lissencephaly (HP:0001339)2.09579084
61Male pseudohermaphroditism (HP:0000037)2.08955967
62Renal Fanconi syndrome (HP:0001994)2.08753750
63Congenital hepatic fibrosis (HP:0002612)2.07381706
64Methylmalonic aciduria (HP:0012120)2.04102691
65Increased serum lactate (HP:0002151)2.02186546
66Bony spicule pigmentary retinopathy (HP:0007737)2.00702330
67Chorioretinal atrophy (HP:0000533)1.99609430
68Decreased central vision (HP:0007663)1.97977309
69Genital tract atresia (HP:0001827)1.97750703
70Hypothermia (HP:0002045)1.96569625
71Retinal dysplasia (HP:0007973)1.94748664
72Abnormality of cells of the erythroid lineage (HP:0012130)1.93864136
73Vaginal atresia (HP:0000148)1.92095961
74Abnormal respiratory epithelium morphology (HP:0012253)1.88944103
75Abnormal respiratory motile cilium morphology (HP:0005938)1.88944103
76Cerebral edema (HP:0002181)1.87593920
77Short tibia (HP:0005736)1.87032516
78Dynein arm defect of respiratory motile cilia (HP:0012255)1.85853107
79Absent/shortened dynein arms (HP:0200106)1.85853107
80Postaxial foot polydactyly (HP:0001830)1.85683676
81Keratoconus (HP:0000563)1.85190109
82Increased corneal curvature (HP:0100692)1.85190109
83Absent rod-and cone-mediated responses on ERG (HP:0007688)1.84990159
84Aplasia/Hypoplasia of the uvula (HP:0010293)1.84067320
85Patellar aplasia (HP:0006443)1.83576783
86Optic nerve hypoplasia (HP:0000609)1.83305586
87Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80481466
88Aplasia/Hypoplasia of the patella (HP:0006498)1.79496665
89Lactic acidosis (HP:0003128)1.78495191
90Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.77025634
91Polyuria (HP:0000103)1.76661811
92Aplasia/Hypoplasia of the spleen (HP:0010451)1.73668035
93Aplasia/hypoplasia of the uterus (HP:0008684)1.72227156
94Abnormality of renal resorption (HP:0011038)1.72179160
95Broad-based gait (HP:0002136)1.70522191
96Poor coordination (HP:0002370)1.70167125
97Supernumerary spleens (HP:0009799)1.69828062
98Gaze-evoked nystagmus (HP:0000640)1.69709776
99Exertional dyspnea (HP:0002875)1.69062114
100Postaxial hand polydactyly (HP:0001162)1.68991972

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.11767430
2BMPR1B3.48118725
3ADRBK23.09649672
4ZAK3.04476922
5ACVR1B2.91024573
6NUAK12.56547988
7WNK32.44931521
8INSRR2.42573744
9WNK42.39177276
10MAP4K22.37876923
11TLK12.33780991
12GRK12.18873652
13TAOK32.09604868
14STK161.74688907
15MKNK21.60017473
16TXK1.60014807
17VRK21.55683065
18MAPK131.54087317
19STK391.52518410
20OXSR11.47442571
21PINK11.44424594
22DAPK21.37168629
23TIE11.36637334
24CASK1.34367436
25VRK11.34125562
26TGFBR11.33414827
27MST41.29298706
28PNCK1.23209547
29STK38L1.16736610
30ADRBK11.16392576
31MKNK11.14050251
32EIF2AK31.12321549
33WEE11.11101102
34TNIK1.10709792
35BCKDK1.10254508
36DYRK21.09571403
37BRSK21.09541459
38CAMKK21.05374025
39MAP3K41.04446125
40TRIM280.98126052
41PLK30.93779119
42TSSK60.93513633
43PLK20.93487421
44PLK40.92115680
45MAP3K120.91973295
46PAK30.91631678
47BUB10.88871516
48PRKCG0.85485786
49STK30.84205875
50PHKG20.81771084
51PHKG10.81771084
52PASK0.81564699
53NEK10.80856610
54PRKCE0.79133429
55TEC0.78959108
56CSNK1G10.77682114
57CDC70.75884946
58NME10.72568339
59CSNK1G20.70172365
60CSNK1G30.69881481
61IKBKB0.69236917
62OBSCN0.68475028
63PIK3CA0.67008143
64MAP2K70.61765991
65MARK10.60644453
66MUSK0.60040868
67CSNK1A1L0.59750636
68TAF10.59473040
69PRKCQ0.59351020
70CHEK20.57783478
71SRPK10.56916856
72RPS6KA50.56645872
73MAPK150.55784727
74MAPKAPK50.54419480
75PLK10.52057379
76EIF2AK20.51485897
77ITK0.49875784
78GRK70.48100519
79BCR0.48099674
80MAP2K60.46096009
81CSNK1A10.44309050
82CAMK2A0.43598071
83PTK2B0.43547568
84KIT0.42311352
85ATR0.42245617
86NEK20.41961299
87PRKACA0.41712737
88PRKCI0.39942726
89MAP3K130.39594365
90MAPKAPK30.37387108
91CDK190.37209943
92CHUK0.36650179
93PKN10.34079816
94ERBB30.34024943
95IRAK10.33958390
96EIF2AK10.30922462
97PRKCA0.30322670
98CSNK2A10.29355964
99CAMK10.27399888
100PIK3CG0.26732162

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.27053335
2Parkinsons disease_Homo sapiens_hsa050122.59999025
3Phototransduction_Homo sapiens_hsa047442.49775289
4Protein export_Homo sapiens_hsa030602.47706826
5RNA polymerase_Homo sapiens_hsa030202.35813353
6Ribosome_Homo sapiens_hsa030102.31366473
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.28938262
8Homologous recombination_Homo sapiens_hsa034402.25280812
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.16481477
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.14028443
11Nitrogen metabolism_Homo sapiens_hsa009102.09545616
12Linoleic acid metabolism_Homo sapiens_hsa005912.08508307
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.96894826
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.96438682
15Selenocompound metabolism_Homo sapiens_hsa004501.90368720
16Basal transcription factors_Homo sapiens_hsa030221.89976020
17Butanoate metabolism_Homo sapiens_hsa006501.89674787
18Proteasome_Homo sapiens_hsa030501.89261217
19Huntingtons disease_Homo sapiens_hsa050161.80686942
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.76246055
21Fanconi anemia pathway_Homo sapiens_hsa034601.73929259
22Alzheimers disease_Homo sapiens_hsa050101.66437157
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59700609
24RNA degradation_Homo sapiens_hsa030181.55595750
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.53699836
26One carbon pool by folate_Homo sapiens_hsa006701.53156227
27Cardiac muscle contraction_Homo sapiens_hsa042601.51295361
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.49127165
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.47638726
30Tryptophan metabolism_Homo sapiens_hsa003801.46890309
31Nicotine addiction_Homo sapiens_hsa050331.45105656
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.40404111
33Caffeine metabolism_Homo sapiens_hsa002321.37905322
34Ether lipid metabolism_Homo sapiens_hsa005651.36006515
35Propanoate metabolism_Homo sapiens_hsa006401.33195908
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30472554
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.19996428
38Peroxisome_Homo sapiens_hsa041461.19657046
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.18518578
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12371796
41Regulation of autophagy_Homo sapiens_hsa041401.07313065
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06585084
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02015654
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00962919
45Chemical carcinogenesis_Homo sapiens_hsa052041.00330437
46Nucleotide excision repair_Homo sapiens_hsa034200.99547350
47Purine metabolism_Homo sapiens_hsa002300.98048303
48Olfactory transduction_Homo sapiens_hsa047400.96725169
49Pyrimidine metabolism_Homo sapiens_hsa002400.94664547
50Taste transduction_Homo sapiens_hsa047420.94540113
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93706674
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.91943931
53Steroid biosynthesis_Homo sapiens_hsa001000.91125884
54Arachidonic acid metabolism_Homo sapiens_hsa005900.90778719
55ABC transporters_Homo sapiens_hsa020100.87805259
56RNA transport_Homo sapiens_hsa030130.85872426
57Retinol metabolism_Homo sapiens_hsa008300.83193734
58Morphine addiction_Homo sapiens_hsa050320.79048098
59Mismatch repair_Homo sapiens_hsa034300.78982088
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.78264710
61Sulfur metabolism_Homo sapiens_hsa009200.78206513
62Collecting duct acid secretion_Homo sapiens_hsa049660.76495667
63Metabolic pathways_Homo sapiens_hsa011000.74763578
64Sulfur relay system_Homo sapiens_hsa041220.73407274
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73039353
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70710388
67Primary immunodeficiency_Homo sapiens_hsa053400.70149570
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68014584
69beta-Alanine metabolism_Homo sapiens_hsa004100.67451852
70Serotonergic synapse_Homo sapiens_hsa047260.67328050
71Non-homologous end-joining_Homo sapiens_hsa034500.65478616
72Vitamin digestion and absorption_Homo sapiens_hsa049770.65255422
73Mineral absorption_Homo sapiens_hsa049780.64053669
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62539281
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61198703
76Histidine metabolism_Homo sapiens_hsa003400.61175253
77Insulin secretion_Homo sapiens_hsa049110.60886898
78GABAergic synapse_Homo sapiens_hsa047270.59537642
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.59082020
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58778010
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58585844
82Fat digestion and absorption_Homo sapiens_hsa049750.58407981
83Glycerolipid metabolism_Homo sapiens_hsa005610.55516908
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52679101
85Asthma_Homo sapiens_hsa053100.52469997
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51421066
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51164170
88Fatty acid degradation_Homo sapiens_hsa000710.47601113
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46766020
90Ovarian steroidogenesis_Homo sapiens_hsa049130.45345963
91Base excision repair_Homo sapiens_hsa034100.44797870
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44025599
93Spliceosome_Homo sapiens_hsa030400.41769882
94Circadian entrainment_Homo sapiens_hsa047130.40981810
95Glutamatergic synapse_Homo sapiens_hsa047240.40030762
96Hedgehog signaling pathway_Homo sapiens_hsa043400.38467519
97Fatty acid elongation_Homo sapiens_hsa000620.37330093
98Glutathione metabolism_Homo sapiens_hsa004800.34741207
99Circadian rhythm_Homo sapiens_hsa047100.32366761
100Arginine and proline metabolism_Homo sapiens_hsa003300.32060576

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