C9ORF69

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)4.49296368
2protein localization to endosome (GO:0036010)4.24615364
3negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.04819426
4regulation of mammary gland epithelial cell proliferation (GO:0033599)3.91499802
5apoptotic process involved in morphogenesis (GO:0060561)3.77680496
6barbed-end actin filament capping (GO:0051016)3.70850230
7regulation of early endosome to late endosome transport (GO:2000641)3.60829614
8pentose-phosphate shunt (GO:0006098)3.52589004
9mannose metabolic process (GO:0006013)3.50489604
10positive regulation of Cdc42 GTPase activity (GO:0043089)3.47330949
11Golgi transport vesicle coating (GO:0048200)3.42145621
12COPI coating of Golgi vesicle (GO:0048205)3.42145621
13pinocytosis (GO:0006907)3.33387956
14amyloid precursor protein catabolic process (GO:0042987)3.32266118
15adherens junction assembly (GO:0034333)3.29739142
16negative regulation of cell size (GO:0045792)3.27420076
17focal adhesion assembly (GO:0048041)3.21652440
18cell-substrate adherens junction assembly (GO:0007045)3.21652440
19proline biosynthetic process (GO:0006561)3.21397060
20glucose catabolic process (GO:0006007)3.17269589
21stress fiber assembly (GO:0043149)3.17198515
22modulation by symbiont of host cellular process (GO:0044068)3.07480537
23activation of Rac GTPase activity (GO:0032863)3.06574743
24cell-substrate junction assembly (GO:0007044)3.05890543
25modulation by virus of host process (GO:0019054)3.02203142
26protein retention in ER lumen (GO:0006621)2.99168459
27NADPH regeneration (GO:0006740)2.96258312
28epithelial cell differentiation involved in prostate gland development (GO:0060742)2.94850674
29maternal placenta development (GO:0001893)2.93424206
30positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.92915706
313-UTR-mediated mRNA stabilization (GO:0070935)2.90547179
32response to laminar fluid shear stress (GO:0034616)2.87156928
33tooth mineralization (GO:0034505)2.84783534
34antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.84291679
35negative regulation of necroptotic process (GO:0060546)2.83018840
36positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.82414635
37modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.78996029
38positive regulation by organism of defense response of other organism involved in symbiotic interact2.78996029
39modulation by symbiont of host immune response (GO:0052553)2.78996029
40positive regulation by symbiont of host defense response (GO:0052509)2.78996029
41modulation by symbiont of host defense response (GO:0052031)2.78996029
42modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.78996029
43maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.78412745
44GDP-mannose metabolic process (GO:0019673)2.74245398
45embryonic process involved in female pregnancy (GO:0060136)2.73162112
46positive regulation of receptor recycling (GO:0001921)2.72798054
47negative regulation of viral release from host cell (GO:1902187)2.70825753
48response to peptidoglycan (GO:0032494)2.70365777
49lymph vessel development (GO:0001945)2.69298214
50planar cell polarity pathway involved in neural tube closure (GO:0090179)2.67318325
51retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.66552739
52antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.65302629
53amyloid precursor protein metabolic process (GO:0042982)2.65157014
54epithelial cell-cell adhesion (GO:0090136)2.64882159
55regulation of chromatin binding (GO:0035561)2.63896583
56modulation by virus of host morphology or physiology (GO:0019048)2.59679111
57negative regulation of cell killing (GO:0031342)2.57902846
58negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.57902846
59regulation of extracellular matrix disassembly (GO:0010715)2.57780019
60endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.56175111
61cytoskeletal anchoring at plasma membrane (GO:0007016)2.55638098
62hemidesmosome assembly (GO:0031581)2.54988686
63intracellular estrogen receptor signaling pathway (GO:0030520)2.53676440
64antigen processing and presentation of endogenous antigen (GO:0019883)2.53101670
65positive regulation of histone deacetylation (GO:0031065)2.52860166
66negative regulation of homotypic cell-cell adhesion (GO:0034111)2.52322982
67basement membrane organization (GO:0071711)2.51174389
68vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.50776895
69regulation of apoptotic process involved in morphogenesis (GO:1902337)2.49468776
70NIK/NF-kappaB signaling (GO:0038061)2.48204315
71peptidyl-arginine omega-N-methylation (GO:0035247)2.48130758
72positive regulation of blood vessel endothelial cell migration (GO:0043536)2.47960122
73positive regulation of myotube differentiation (GO:0010831)2.47871377
74regulation of NFAT protein import into nucleus (GO:0051532)2.46549436
75pentose metabolic process (GO:0019321)2.46165099
76glucose 6-phosphate metabolic process (GO:0051156)2.46076564
77regulation of necroptotic process (GO:0060544)2.45218692
78desmosome organization (GO:0002934)2.44030434
79negative regulation of fatty acid transport (GO:2000192)2.43897926
80positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.40698737
81cellular response to virus (GO:0098586)2.38867936
82negative regulation of myotube differentiation (GO:0010832)2.37926159
83regulation of necrotic cell death (GO:0010939)2.36372276
84regulation of leukocyte degranulation (GO:0043300)2.35251475
85regulation of glucose import in response to insulin stimulus (GO:2001273)2.34457879
86apoptotic process involved in development (GO:1902742)2.33895914
87regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.33202919
88cellular protein complex localization (GO:0034629)2.33039273
89regulation of defense response to virus by virus (GO:0050690)2.32206694
90regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.30608278
91membrane protein ectodomain proteolysis (GO:0006509)2.29207691
92mammary gland epithelial cell differentiation (GO:0060644)2.29038906
93protein maturation by protein folding (GO:0022417)2.27810707
94antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.26589491
95semaphorin-plexin signaling pathway (GO:0071526)2.24826275
96skin morphogenesis (GO:0043589)2.23475715
97signal complex assembly (GO:0007172)2.20617841
98hyaluronan catabolic process (GO:0030214)2.20597174
99UV protection (GO:0009650)2.19732571
100detection of other organism (GO:0098543)2.18920830

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.20860255
2VDR_21846776_ChIP-Seq_THP-1_Human2.94617656
3* LXR_22292898_ChIP-Seq_THP-1_Human2.72653937
4MYC_22102868_ChIP-Seq_BL_Human2.63399252
5ELK3_25401928_ChIP-Seq_HUVEC_Human2.61749753
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.45589277
7KDM2B_26808549_Chip-Seq_SUP-B15_Human2.30446179
8NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.29776095
9RACK7_27058665_Chip-Seq_MCF-7_Human2.27317644
10* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.27126479
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.26799125
12TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24429043
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.21391530
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.15625126
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.08941722
16TCF7_22412390_ChIP-Seq_EML_Mouse1.96676125
17KDM2B_26808549_Chip-Seq_DND41_Human1.93854902
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.93830142
19ZNF263_19887448_ChIP-Seq_K562_Human1.90737868
20TET1_21451524_ChIP-Seq_MESCs_Mouse1.65022942
21* KDM2B_26808549_Chip-Seq_K562_Human1.64246301
22VDR_24763502_ChIP-Seq_THP-1_Human1.63040107
23DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.60852622
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59657805
25UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.55925877
26KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.54354089
27* P68_20966046_ChIP-Seq_HELA_Human1.54004241
28CTCF_27219007_Chip-Seq_ERYTHROID_Human1.53410450
29SRY_22984422_ChIP-ChIP_TESTIS_Rat1.53365263
30MAF_26560356_Chip-Seq_TH1_Human1.51989511
31ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.51952198
32KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.51220829
33KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48697649
34SA1_27219007_Chip-Seq_ERYTHROID_Human1.47979874
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44774086
36RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.44040579
37KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.43809961
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.43082291
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41921050
40KDM2B_26808549_Chip-Seq_JURKAT_Human1.40195396
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38742347
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.38434780
43P300_27058665_Chip-Seq_ZR-75-30cells_Human1.37020693
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36567586
45CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36135361
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.35603827
47EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.34228674
48KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32720246
49* MAF_26560356_Chip-Seq_TH2_Human1.30651172
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.30238644
51* SMC4_20622854_ChIP-Seq_HELA_Human1.30216408
52ATF3_27146783_Chip-Seq_COLON_Human1.29901256
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29125374
54SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27889273
55UTX_26944678_Chip-Seq_JUKART_Human1.27079116
56CREB1_26743006_Chip-Seq_LNCaP_Human1.23687887
57* NCOR1_26117541_ChIP-Seq_K562_Human1.23013989
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22094874
59GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21611726
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20393421
61ELF1_20517297_ChIP-Seq_JURKAT_Human1.19807459
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19172384
63* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19007605
64TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18627238
65TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17218219
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.17152782
67NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16664395
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15903296
69CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.15869433
70MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.14916573
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13366198
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12997911
73CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12312869
74CLOCK_20551151_ChIP-Seq_293T_Human1.11385387
75* BCOR_27268052_Chip-Seq_Bcells_Human1.10827764
76E2F7_22180533_ChIP-Seq_HELA_Human1.10623607
77WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08353656
78SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07682460
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07282572
80SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07202535
81NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06672648
82HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06307968
83MYB_21317192_ChIP-Seq_ERMYB_Mouse1.04243893
84ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.03359652
85* BCL6_27268052_Chip-Seq_Bcells_Human1.03180969
86DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02262811
87GATA1_19941827_ChIP-Seq_MEL_Mouse1.01355504
88CTCF_21964334_Chip-Seq_Bcells_Human1.00882468
89CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99853100
90PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99670128
91* TP53_22127205_ChIP-Seq_IMR90_Human0.99007396
92CTCF_26484167_Chip-Seq_Bcells_Mouse0.98727666
93FOXM1_23109430_ChIP-Seq_U2OS_Human0.98233721
94MYC_18358816_ChIP-ChIP_MESCs_Mouse0.98224016
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96140239
96PPARA_22158963_ChIP-Seq_LIVER_Mouse0.95942099
97CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95927742
98SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.95883953
99RUNX1_27514584_Chip-Seq_MCF-7_Human0.94621535
100RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.94459802

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.79827288
2MP0005451_abnormal_body_composition3.14027013
3MP0010234_abnormal_vibrissa_follicle2.60661913
4MP0008260_abnormal_autophagy2.59847111
5MP0002877_abnormal_melanocyte_morpholog2.56243973
6MP0005058_abnormal_lysosome_morphology2.56156989
7MP0001849_ear_inflammation2.51107511
8MP0004858_abnormal_nervous_system2.38339061
9MP0005076_abnormal_cell_differentiation2.34177579
10MP0003191_abnormal_cellular_cholesterol2.27788070
11MP0003566_abnormal_cell_adhesion2.24622679
12MP0008438_abnormal_cutaneous_collagen2.20143444
13MP0003303_peritoneal_inflammation2.15118081
14MP0004185_abnormal_adipocyte_glucose2.12748269
15MP0002796_impaired_skin_barrier2.07168836
16MP0003436_decreased_susceptibility_to2.05217912
17MP0003453_abnormal_keratinocyte_physiol2.03172966
18MP0000678_abnormal_parathyroid_gland2.02934630
19MP0009840_abnormal_foam_cell1.88982707
20MP0009333_abnormal_splenocyte_physiolog1.77934842
21MP0003300_gastrointestinal_ulcer1.77145490
22MP0005623_abnormal_meninges_morphology1.69874200
23MP0005501_abnormal_skin_physiology1.66168804
24MP0009278_abnormal_bone_marrow1.65968720
25MP0004233_abnormal_muscle_weight1.63613796
26MP0002249_abnormal_larynx_morphology1.63562458
27MP0000858_altered_metastatic_potential1.60987342
28MP0010030_abnormal_orbit_morphology1.60957408
29MP0004947_skin_inflammation1.55067017
30MP0003172_abnormal_lysosome_physiology1.46966549
31MP0003091_abnormal_cell_migration1.38286568
32MP0005666_abnormal_adipose_tissue1.37913363
33MP0003279_aneurysm1.35966230
34MP0000490_abnormal_crypts_of1.35262538
35MP0005409_darkened_coat_color1.32888702
36MP0005464_abnormal_platelet_physiology1.31761651
37MP0002060_abnormal_skin_morphology1.26201699
38MP0000733_abnormal_muscle_development1.25589655
39MP0005023_abnormal_wound_healing1.23518526
40MP0010352_gastrointestinal_tract_polyps1.22713477
41MP0003763_abnormal_thymus_physiology1.19590625
42MP0004510_myositis1.16439140
43MP0004272_abnormal_basement_membrane1.16329926
44MP0005375_adipose_tissue_phenotype1.15603742
45MP0000537_abnormal_urethra_morphology1.14818473
46MP0001348_abnormal_lacrimal_gland1.14317774
47MP0001958_emphysema1.13803996
48MP0005257_abnormal_intraocular_pressure1.12137965
49MP0005670_abnormal_white_adipose1.07530678
50MP0003075_altered_response_to1.06685900
51MP0009053_abnormal_anal_canal1.03157947
52MP0002419_abnormal_innate_immunity1.02808951
53MP0002998_abnormal_bone_remodeling1.01845082
54MP0001533_abnormal_skeleton_physiology1.00675429
55MP0003329_amyloid_beta_deposits0.99854240
56MP0000003_abnormal_adipose_tissue0.97650590
57MP0005025_abnormal_response_to0.96792951
58MP0001216_abnormal_epidermal_layer0.95575186
59MP0001873_stomach_inflammation0.94290832
60MP0001730_embryonic_growth_arrest0.93327091
61MP0009931_abnormal_skin_appearance0.92961205
62MP0000751_myopathy0.92854905
63MP0010155_abnormal_intestine_physiology0.91188937
64MP0004264_abnormal_extraembryonic_tissu0.91025588
65MP0003183_abnormal_peptide_metabolism0.90613542
66MP0004381_abnormal_hair_follicle0.89733044
67MP0000759_abnormal_skeletal_muscle0.89335044
68MP0003448_altered_tumor_morphology0.88786922
69MP0000467_abnormal_esophagus_morphology0.88422554
70MP0002089_abnormal_postnatal_growth/wei0.88285143
71MP0005621_abnormal_cell_physiology0.86473211
72MP0000750_abnormal_muscle_regeneration0.86118369
73MP0000747_muscle_weakness0.85995870
74MP0003828_pulmonary_edema0.85259953
75MP0000681_abnormal_thyroid_gland0.84433237
76MP0000685_abnormal_immune_system0.83077635
77MP0002396_abnormal_hematopoietic_system0.79601713
78MP0000767_abnormal_smooth_muscle0.79323300
79MP0002098_abnormal_vibrissa_morphology0.79183190
80MP0004808_abnormal_hematopoietic_stem0.79049547
81MP0005083_abnormal_biliary_tract0.78919974
82MP0000343_altered_response_to0.78799910
83MP0005000_abnormal_immune_tolerance0.78473285
84MP0001346_abnormal_lacrimal_gland0.77230883
85MP0000703_abnormal_thymus_morphology0.74818678
86MP0001835_abnormal_antigen_presentation0.74746995
87MP0001661_extended_life_span0.74674315
88MP0005390_skeleton_phenotype0.74032270
89MP0000477_abnormal_intestine_morphology0.73542900
90MP0002398_abnormal_bone_marrow0.73150304
91MP0005275_abnormal_skin_tensile0.72530766
92MP0001545_abnormal_hematopoietic_system0.72468475
93MP0005397_hematopoietic_system_phenotyp0.72468475
94MP0001819_abnormal_immune_cell0.70746385
95MP0003724_increased_susceptibility_to0.70709991
96MP0002420_abnormal_adaptive_immunity0.70455524
97MP0001790_abnormal_immune_system0.69799724
98MP0005387_immune_system_phenotype0.69799724
99MP0006082_CNS_inflammation0.68881427
100MP0002132_abnormal_respiratory_system0.68299368

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.15839225
2Premature rupture of membranes (HP:0001788)3.13965600
3Hyperacusis (HP:0010780)3.03418470
4Vertebral compression fractures (HP:0002953)2.97040631
5Increased connective tissue (HP:0009025)2.86553437
6Distal lower limb amyotrophy (HP:0008944)2.75590150
7Achilles tendon contracture (HP:0001771)2.71562116
8Distal lower limb muscle weakness (HP:0009053)2.68608363
9Fragile skin (HP:0001030)2.58228982
10Ulnar bowing (HP:0003031)2.50483927
11Eczematoid dermatitis (HP:0000976)2.46792078
12Broad face (HP:0000283)2.41637758
13Upper limb amyotrophy (HP:0009129)2.41014043
14Distal upper limb amyotrophy (HP:0007149)2.41014043
15Abnormality of the distal phalanges of the toes (HP:0010182)2.39189558
16Centrally nucleated skeletal muscle fibers (HP:0003687)2.38502738
17Thin bony cortex (HP:0002753)2.38422360
18Abnormality of the Achilles tendon (HP:0005109)2.37163672
19Cerebral aneurysm (HP:0004944)2.34750097
20Increased variability in muscle fiber diameter (HP:0003557)2.32678983
21Recurrent bacterial skin infections (HP:0005406)2.31297653
22Stridor (HP:0010307)2.30114413
23Recurrent abscess formation (HP:0002722)2.29364745
24Short nail (HP:0001799)2.21372745
25Abnormality of skeletal muscle fiber size (HP:0012084)2.21221164
26Increased cerebral lipofuscin (HP:0011813)2.20539046
27Myopathic facies (HP:0002058)2.18877228
28Cellulitis (HP:0100658)2.15453932
29Genu recurvatum (HP:0002816)2.08373679
30Obstructive sleep apnea (HP:0002870)2.07420785
31Spinal rigidity (HP:0003306)2.05895632
32Polygenic inheritance (HP:0010982)2.05477229
33Long palpebral fissure (HP:0000637)2.04916954
34Cervical subluxation (HP:0003308)2.04808968
35Disproportionate tall stature (HP:0001519)2.03349088
36Bulbar palsy (HP:0001283)1.99374472
37Increased neuronal autofluorescent lipopigment (HP:0002074)1.98474046
38Difficulty climbing stairs (HP:0003551)1.98098250
39Blue sclerae (HP:0000592)1.96557602
40Abnormality of macrophages (HP:0004311)1.94106816
41Mitral regurgitation (HP:0001653)1.93535136
42Elbow flexion contracture (HP:0002987)1.93223322
43Flat acetabular roof (HP:0003180)1.91691810
44Dilatation of the ascending aorta (HP:0005111)1.89134612
45Broad distal phalanx of finger (HP:0009836)1.88644614
46Osteolytic defects of the hand bones (HP:0009699)1.88105260
47Osteolytic defects of the phalanges of the hand (HP:0009771)1.88105260
48Upper motor neuron abnormality (HP:0002127)1.88054515
49Generalized amyotrophy (HP:0003700)1.87864862
50Mildly elevated creatine phosphokinase (HP:0008180)1.86938561
51Shallow orbits (HP:0000586)1.85595290
52Atrophic scars (HP:0001075)1.84392662
53Insomnia (HP:0100785)1.83906957
54Axonal loss (HP:0003447)1.82397386
55Abnormality of the thoracic spine (HP:0100711)1.81751836
56Ankyloglossia (HP:0010296)1.79948709
57Dysostosis multiplex (HP:0000943)1.78534822
58Trismus (HP:0000211)1.78208655
59Abnormality of oral frenula (HP:0000190)1.76866341
60Hemorrhage of the eye (HP:0011885)1.76561408
61Spinal cord compression (HP:0002176)1.76496351
62Lower limb amyotrophy (HP:0007210)1.76253426
63Ragged-red muscle fibers (HP:0003200)1.73502042
64Hypertensive crisis (HP:0100735)1.72839920
65Hyperparathyroidism (HP:0000843)1.72832476
66Hand muscle atrophy (HP:0009130)1.71695023
67Abnormality of the distal phalanx of the thumb (HP:0009617)1.71660234
68Biconcave vertebral bodies (HP:0004586)1.68804664
69Abnormality of the umbilical cord (HP:0010881)1.68232021
70Loss of speech (HP:0002371)1.67627076
71Cerebral inclusion bodies (HP:0100314)1.66966827
72Bone pain (HP:0002653)1.66363918
73Subacute progressive viral hepatitis (HP:0006572)1.66127867
74Ankle contracture (HP:0006466)1.66009308
75Selective tooth agenesis (HP:0001592)1.65341212
76Gastrointestinal inflammation (HP:0004386)1.65074357
77Abnormality of glycolipid metabolism (HP:0010969)1.64908174
78Abnormality of liposaccharide metabolism (HP:0010968)1.64908174
79Abnormality of glycosphingolipid metabolism (HP:0004343)1.64908174
80Gingivitis (HP:0000230)1.64858188
81Truncus arteriosus (HP:0001660)1.64782262
82Obstructive lung disease (HP:0006536)1.64461588
83Chronic obstructive pulmonary disease (HP:0006510)1.64461588
84Progressive muscle weakness (HP:0003323)1.64175327
85Interstitial pulmonary disease (HP:0006530)1.63416290
86Abnormal ossification of hand bones (HP:0005921)1.63210184
87Hypertriglyceridemia (HP:0002155)1.63173212
88Asymmetry of the thorax (HP:0001555)1.62192036
89Abnormality of the nasal mucosa (HP:0000433)1.60269106
90Increased IgE level (HP:0003212)1.59959266
91Gastrointestinal dysmotility (HP:0002579)1.59840537
92Colitis (HP:0002583)1.59570800
93Hypercortisolism (HP:0001578)1.58788377
94Polycythemia (HP:0001901)1.57634737
95Petechiae (HP:0000967)1.56635681
96Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.56161657
97Wormian bones (HP:0002645)1.55626173
98Reticulocytosis (HP:0001923)1.55580484
99Rectal prolapse (HP:0002035)1.55252648
100Advanced eruption of teeth (HP:0006288)1.55191731

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.76048856
2SMG14.26622964
3PRPF4B3.53878679
4ERN13.26632903
5IRAK33.20457002
6SIK12.60487215
7NME22.39838737
8ICK2.29772932
9MAP2K32.25289645
10EEF2K2.23398312
11TTN1.94290240
12EPHA21.87671797
13TAOK21.87075007
14MAP3K101.79812733
15RIPK11.72366701
16ARAF1.64053564
17MAP3K111.60276488
18PKN21.57051211
19MAP3K31.53353344
20MST1R1.43078232
21PAK41.41457506
22TAOK11.32914387
23PRKD31.32851070
24TESK11.30993218
25IRAK41.24775591
26MAP3K131.23062818
27CDK121.19647725
28MAP3K11.14341175
29PTK61.14265226
30IRAK21.11945602
31MAP4K11.08715355
32BMX1.08558024
33PDGFRA1.08169499
34PRKD21.07379862
35TESK21.07007926
36FGFR41.05931141
37KSR21.05421103
38BRAF1.00489020
39RIPK40.95121648
40TYK20.94798649
41EPHB10.93437089
42LMTK20.93210380
43PDPK10.92721488
44MAP3K80.89718888
45GRK60.89693447
46RPS6KA20.89376578
47PTK20.88852328
48ZAP700.87861798
49PIM20.87480824
50TBK10.83160713
51RPS6KC10.80932350
52RPS6KL10.80932350
53MARK20.80807303
54MTOR0.79855044
55MAPK110.79516433
56PRKG20.79008637
57CDC42BPA0.75508612
58CSK0.72171469
59LRRK20.70546011
60ILK0.64371493
61MAP3K60.63257441
62LATS20.60901036
63MAP2K20.60753582
64VRK20.60359926
65MOS0.59413574
66CDK40.57425708
67HIPK20.57306542
68KDR0.56898113
69RPS6KA60.54899827
70RPS6KB20.54884749
71MAPK120.54338932
72CDK70.54196836
73STK380.53490017
74JAK30.53317062
75ABL20.51770735
76SCYL20.50609875
77PDK10.49955382
78MET0.48121801
79FES0.45221666
80BLK0.44364792
81STK100.42599241
82AURKA0.41911369
83EPHB20.40972767
84MAP3K140.40782609
85DDR20.40004724
86MELK0.39800047
87TNK20.39266032
88CAMKK10.39112917
89STK40.37573110
90NTRK10.37034792
91CAMK1D0.36306809
92MAPKAPK20.35307258
93HCK0.35224339
94TAF10.35171713
95TGFBR20.34656407
96AKT20.33745792
97RET0.32812334
98PAK10.31949838
99DAPK30.31907513
100DAPK10.31882444

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.38556182
2Other glycan degradation_Homo sapiens_hsa005112.37887515
3Sulfur relay system_Homo sapiens_hsa041222.35337042
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.19974909
5Chronic myeloid leukemia_Homo sapiens_hsa052202.14321904
6Acute myeloid leukemia_Homo sapiens_hsa052212.07814544
7Bladder cancer_Homo sapiens_hsa052191.96553512
8Non-small cell lung cancer_Homo sapiens_hsa052231.92106101
9Notch signaling pathway_Homo sapiens_hsa043301.89760320
10Pentose phosphate pathway_Homo sapiens_hsa000301.78198971
11Pancreatic cancer_Homo sapiens_hsa052121.74590253
12Central carbon metabolism in cancer_Homo sapiens_hsa052301.74160701
13VEGF signaling pathway_Homo sapiens_hsa043701.71941213
14Fructose and mannose metabolism_Homo sapiens_hsa000511.53974672
15B cell receptor signaling pathway_Homo sapiens_hsa046621.48781058
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.48227415
17Osteoclast differentiation_Homo sapiens_hsa043801.45278330
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.44974785
19Galactose metabolism_Homo sapiens_hsa000521.44135366
20Endometrial cancer_Homo sapiens_hsa052131.42971561
21Thyroid cancer_Homo sapiens_hsa052161.40440669
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.37513142
23Neurotrophin signaling pathway_Homo sapiens_hsa047221.27466208
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.24492398
25Prion diseases_Homo sapiens_hsa050201.23601699
26Glioma_Homo sapiens_hsa052141.19650321
27Leukocyte transendothelial migration_Homo sapiens_hsa046701.16759414
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16672601
29mTOR signaling pathway_Homo sapiens_hsa041501.16667811
30Insulin signaling pathway_Homo sapiens_hsa049101.15742559
31Hepatitis C_Homo sapiens_hsa051601.14831479
32Small cell lung cancer_Homo sapiens_hsa052221.14564966
33Apoptosis_Homo sapiens_hsa042101.14420880
34Shigellosis_Homo sapiens_hsa051311.11454411
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11176152
36Renal cell carcinoma_Homo sapiens_hsa052111.10743942
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.10223982
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07561145
39Proteoglycans in cancer_Homo sapiens_hsa052051.06371354
40Leishmaniasis_Homo sapiens_hsa051401.04717548
41Focal adhesion_Homo sapiens_hsa045101.03720544
42Biosynthesis of amino acids_Homo sapiens_hsa012301.03471991
43Hepatitis B_Homo sapiens_hsa051611.02542118
44Lysosome_Homo sapiens_hsa041421.01604105
45Toxoplasmosis_Homo sapiens_hsa051450.98634182
46Endocytosis_Homo sapiens_hsa041440.97582427
47Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95205125
48ErbB signaling pathway_Homo sapiens_hsa040120.94312968
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94154097
50Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93257915
51Amoebiasis_Homo sapiens_hsa051460.92819407
52Sphingolipid signaling pathway_Homo sapiens_hsa040710.92557927
53TNF signaling pathway_Homo sapiens_hsa046680.90403205
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89762574
55Colorectal cancer_Homo sapiens_hsa052100.89586245
56HTLV-I infection_Homo sapiens_hsa051660.89187422
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.89077336
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.88770401
59Tuberculosis_Homo sapiens_hsa051520.87020957
60GnRH signaling pathway_Homo sapiens_hsa049120.86665207
61Salmonella infection_Homo sapiens_hsa051320.84513005
62Viral carcinogenesis_Homo sapiens_hsa052030.81719143
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80940444
64AMPK signaling pathway_Homo sapiens_hsa041520.80019978
65T cell receptor signaling pathway_Homo sapiens_hsa046600.78055383
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77931856
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77333918
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.76841764
69Influenza A_Homo sapiens_hsa051640.75949101
70Prostate cancer_Homo sapiens_hsa052150.75477673
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75247168
72Insulin resistance_Homo sapiens_hsa049310.72852141
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72611974
74Prolactin signaling pathway_Homo sapiens_hsa049170.72543442
75Vibrio cholerae infection_Homo sapiens_hsa051100.70899753
76MicroRNAs in cancer_Homo sapiens_hsa052060.70313953
77Inositol phosphate metabolism_Homo sapiens_hsa005620.69915980
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69812255
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68325540
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67738027
81Malaria_Homo sapiens_hsa051440.67617725
82HIF-1 signaling pathway_Homo sapiens_hsa040660.65768124
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65694116
84Vitamin B6 metabolism_Homo sapiens_hsa007500.64757054
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64666442
86Choline metabolism in cancer_Homo sapiens_hsa052310.64653404
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.63378431
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63161060
89Measles_Homo sapiens_hsa051620.60816741
90Platelet activation_Homo sapiens_hsa046110.60674332
91Herpes simplex infection_Homo sapiens_hsa051680.59184981
92Chemokine signaling pathway_Homo sapiens_hsa040620.56262880
93Estrogen signaling pathway_Homo sapiens_hsa049150.55217190
94N-Glycan biosynthesis_Homo sapiens_hsa005100.54684118
95Carbon metabolism_Homo sapiens_hsa012000.54147916
96Adherens junction_Homo sapiens_hsa045200.53731864
97Base excision repair_Homo sapiens_hsa034100.52188825
98Pertussis_Homo sapiens_hsa051330.50335930
99ECM-receptor interaction_Homo sapiens_hsa045120.49676124
100Viral myocarditis_Homo sapiens_hsa054160.48871099

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