C9ORF47

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)4.60407229
2central nervous system myelination (GO:0022010)4.60407229
3dermatan sulfate biosynthetic process (GO:0030208)4.57664856
4negative regulation of astrocyte differentiation (GO:0048712)4.42227044
5negative regulation of oligodendrocyte differentiation (GO:0048715)4.36285631
6regulation of hippo signaling (GO:0035330)4.32251367
7dermatan sulfate metabolic process (GO:0030205)4.20930588
8mesenchymal cell development (GO:0014031)4.12801055
9neural crest cell development (GO:0014032)3.91365771
10positive regulation by symbiont of host defense response (GO:0052509)3.83352452
11modulation by symbiont of host defense response (GO:0052031)3.83352452
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.83352452
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.83352452
14positive regulation by organism of defense response of other organism involved in symbiotic interact3.83352452
15modulation by symbiont of host immune response (GO:0052553)3.83352452
16stem cell development (GO:0048864)3.67313880
17sympathetic nervous system development (GO:0048485)3.61282781
18ventricular septum morphogenesis (GO:0060412)3.54377796
19limb bud formation (GO:0060174)3.46268119
20endocardial cushion development (GO:0003197)3.42616948
21regulation of mesenchymal cell apoptotic process (GO:2001053)3.31215590
22anterior/posterior axis specification, embryo (GO:0008595)3.25840678
23detection of molecule of bacterial origin (GO:0032490)3.25623141
24heart valve formation (GO:0003188)3.23997768
25regulation of astrocyte differentiation (GO:0048710)3.21859277
26microglial cell activation (GO:0001774)3.15933227
27SMAD protein complex assembly (GO:0007183)3.11777004
28metanephric mesenchyme development (GO:0072075)3.08936186
29negative regulation of smooth muscle cell differentiation (GO:0051151)3.08818054
30cell migration involved in heart development (GO:0060973)3.08632228
31endocardial cushion morphogenesis (GO:0003203)3.08370364
32cell wall macromolecule catabolic process (GO:0016998)3.05538391
33urinary tract smooth muscle contraction (GO:0014848)3.01376980
34negative regulation of translation, ncRNA-mediated (GO:0040033)2.97610445
35regulation of translation, ncRNA-mediated (GO:0045974)2.97610445
36negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.97610445
37kidney mesenchyme development (GO:0072074)2.96033382
38neuroblast proliferation (GO:0007405)2.91056386
39forebrain neuron differentiation (GO:0021879)2.89797817
40Notch signaling involved in heart development (GO:0061314)2.89219081
41positive regulation of metanephros development (GO:0072216)2.84527327
42regulation of axon extension involved in axon guidance (GO:0048841)2.84298772
43atrial septum morphogenesis (GO:0060413)2.83257553
44atrioventricular valve morphogenesis (GO:0003181)2.81365812
45response to peptidoglycan (GO:0032494)2.80713285
46mesenchyme morphogenesis (GO:0072132)2.79669540
47lateral sprouting from an epithelium (GO:0060601)2.74495112
48negative regulation of axon extension involved in axon guidance (GO:0048843)2.70245031
49negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.70129199
50negative regulation of glial cell differentiation (GO:0045686)2.67496981
51cell migration involved in sprouting angiogenesis (GO:0002042)2.65144483
52coronary vasculature morphogenesis (GO:0060977)2.64593457
53regulation of male gonad development (GO:2000018)2.64313154
54regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.63589959
55epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.62603734
56regulation of oligodendrocyte differentiation (GO:0048713)2.61206771
57regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.60937537
58cerebral cortex neuron differentiation (GO:0021895)2.60527655
59regulation of axon guidance (GO:1902667)2.59694325
60negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.55548987
61gamma-aminobutyric acid transport (GO:0015812)2.49710323
62response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.47796051
63response to host (GO:0075136)2.47796051
64response to host defenses (GO:0052200)2.47796051
65positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.47694510
66lens morphogenesis in camera-type eye (GO:0002089)2.46510782
67outflow tract morphogenesis (GO:0003151)2.46028205
68mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.45671100
69lymphangiogenesis (GO:0001946)2.45552636
70response to host immune response (GO:0052572)2.45157786
71response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.45157786
72embryonic camera-type eye morphogenesis (GO:0048596)2.44495915
73cardiac septum morphogenesis (GO:0060411)2.44145000
74regulation of macrophage cytokine production (GO:0010935)2.43994775
75positive regulation of fatty acid beta-oxidation (GO:0032000)2.43407406
76cranial nerve morphogenesis (GO:0021602)2.42843746
77heart valve morphogenesis (GO:0003179)2.42763499
78ventricular septum development (GO:0003281)2.42742426
79somite development (GO:0061053)2.41850271
80artery development (GO:0060840)2.41069675
81negative regulation of fatty acid transport (GO:2000192)2.40855175
82postsynaptic membrane organization (GO:0001941)2.40468668
83inner ear receptor cell development (GO:0060119)2.39895759
84pericardium development (GO:0060039)2.39415654
85cell wall macromolecule metabolic process (GO:0044036)2.38577099
86positive regulation of catenin import into nucleus (GO:0035413)2.38478258
87cGMP-mediated signaling (GO:0019934)2.38102221
88primitive streak formation (GO:0090009)2.37544210
89positive regulation of male gonad development (GO:2000020)2.37481199
90negative regulation of gliogenesis (GO:0014014)2.36272553
91mammary gland development (GO:0030879)2.35407549
92artery morphogenesis (GO:0048844)2.35079360
93negative regulation of axon guidance (GO:1902668)2.34775203
94hypotonic response (GO:0006971)2.34619674
95cochlea development (GO:0090102)2.32638971
96regulation of smooth muscle cell differentiation (GO:0051150)2.32452515
97positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.32158396
98tonic smooth muscle contraction (GO:0014820)2.31189407
99macrophage activation (GO:0042116)2.30621262
100cellular extravasation (GO:0045123)2.28997409

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.01412913
2SMAD_19615063_ChIP-ChIP_OVARY_Human2.74631021
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.59429540
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.55619928
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.46912908
6GBX2_23144817_ChIP-Seq_PC3_Human2.39257797
7* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.26227541
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03976194
9AHR_22903824_ChIP-Seq_MCF-7_Human2.01962659
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97402187
11CBX2_27304074_Chip-Seq_ESCs_Mouse1.92573285
12EED_16625203_ChIP-ChIP_MESCs_Mouse1.90848405
13PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.90420805
14CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.88699281
15ARNT_22903824_ChIP-Seq_MCF-7_Human1.80946206
16PIAS1_25552417_ChIP-Seq_VCAP_Human1.74145650
17JARID2_20064375_ChIP-Seq_MESCs_Mouse1.73780842
18AR_21572438_ChIP-Seq_LNCaP_Human1.73059444
19TP53_16413492_ChIP-PET_HCT116_Human1.71936787
20ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71018031
21RNF2_27304074_Chip-Seq_ESCs_Mouse1.70923410
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.67407690
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.64647219
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.63101129
25EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.62642813
26TP53_18474530_ChIP-ChIP_U2OS_Human1.62610634
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62337631
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58030660
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.57638328
30RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.56515057
31ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.56385960
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.56284304
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.47308182
34ISL1_27105846_Chip-Seq_CPCs_Mouse1.45941164
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45672280
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43794627
37NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.43279064
38NRF2_20460467_ChIP-Seq_MEFs_Mouse1.43279064
39* CJUN_26792858_Chip-Seq_BT549_Human1.41132899
40SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.40674001
41TRIM28_21343339_ChIP-Seq_HEK293_Human1.40616828
42VDR_24787735_ChIP-Seq_THP-1_Human1.40011263
43JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37775972
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.36875232
45RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36743622
46EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36743622
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36432990
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.34698323
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33941412
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33941412
51FOXM1_26456572_ChIP-Seq_MCF-7_Human1.32432240
52RXR_22108803_ChIP-Seq_LS180_Human1.31732008
53BRD4_25478319_ChIP-Seq_HGPS_Human1.31718149
54ER_23166858_ChIP-Seq_MCF-7_Human1.31061350
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30965489
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28681727
57TP53_20018659_ChIP-ChIP_R1E_Mouse1.28580889
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27811796
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.27795739
60CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.26878348
61RING1B_27294783_Chip-Seq_ESCs_Mouse1.26682971
62FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26420431
63* SMAD3_21741376_ChIP-Seq_HESCs_Human1.25491113
64KDM2B_26808549_Chip-Seq_REH_Human1.25255127
65ESR1_21235772_ChIP-Seq_MCF-7_Human1.25200015
66Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24942143
67STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.24323390
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.23527078
69RING1B_27294783_Chip-Seq_NPCs_Mouse1.22568130
70YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18413236
71WT1_19549856_ChIP-ChIP_CCG9911_Human1.18051146
72MTF2_20144788_ChIP-Seq_MESCs_Mouse1.17425038
73ESR1_20079471_ChIP-ChIP_T-47D_Human1.16766715
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15778434
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15619813
76RNF2_27304074_Chip-Seq_NSC_Mouse1.15307890
77LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14494363
78* P300_19829295_ChIP-Seq_ESCs_Human1.14188317
79WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13934224
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13053392
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12382647
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09767056
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09230309
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09140049
85ELK4_26923725_Chip-Seq_MESODERM_Mouse1.08545687
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08392008
87TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07616887
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.07055741
89ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05606861
90BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04973646
91SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04062593
92SMAD4_21799915_ChIP-Seq_A2780_Human1.04025935
93NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03311326
94EWS_26573619_Chip-Seq_HEK293_Human1.01498539
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00787064
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00619858
97CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99109569
98TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98737691
99NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98647239
100TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98595496

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.21513135
2MP0009384_cardiac_valve_regurgitation3.38197910
3MP0000534_abnormal_ureter_morphology3.05337580
4MP0003136_yellow_coat_color2.93310574
5MP0003705_abnormal_hypodermis_morpholog2.92557390
6MP0005503_abnormal_tendon_morphology2.91792726
7MP0000537_abnormal_urethra_morphology2.68378858
8MP0002009_preneoplasia2.60873320
9MP0003942_abnormal_urinary_system2.59393401
10MP0000767_abnormal_smooth_muscle2.22204877
11MP0002653_abnormal_ependyma_morphology2.08062837
12MP0000049_abnormal_middle_ear2.05620516
13MP0006054_spinal_hemorrhage2.04171250
14MP0003279_aneurysm2.02570612
15MP0008961_abnormal_basal_metabolism1.99680328
16MP0005187_abnormal_penis_morphology1.98609038
17MP0004133_heterotaxia1.91426768
18MP0002751_abnormal_autonomic_nervous1.82145121
19MP0005076_abnormal_cell_differentiation1.79250247
20MP0001485_abnormal_pinna_reflex1.72071120
21MP0003828_pulmonary_edema1.71998320
22MP0008438_abnormal_cutaneous_collagen1.69514543
23MP0001958_emphysema1.66543109
24MP0001879_abnormal_lymphatic_vessel1.65939998
25MP0009250_abnormal_appendicular_skeleto1.60689466
26MP0008057_abnormal_DNA_replication1.57788670
27MP0003091_abnormal_cell_migration1.57428013
28MP0005367_renal/urinary_system_phenotyp1.55428741
29MP0000516_abnormal_urinary_system1.55428741
30MP0000538_abnormal_urinary_bladder1.51562665
31MP0005174_abnormal_tail_pigmentation1.50305628
32MP0003283_abnormal_digestive_organ1.48668774
33MP0005623_abnormal_meninges_morphology1.44958828
34MP0003937_abnormal_limbs/digits/tail_de1.44454067
35MP0009053_abnormal_anal_canal1.44310783
36MP0003724_increased_susceptibility_to1.42647988
37MP0009278_abnormal_bone_marrow1.42260995
38MP0005595_abnormal_vascular_smooth1.41952344
39MP0004885_abnormal_endolymph1.37418337
40MP0002282_abnormal_trachea_morphology1.37136465
41MP0004381_abnormal_hair_follicle1.36517255
42MP0003195_calcinosis1.32086836
43MP0004510_myositis1.23571291
44MP0005197_abnormal_uvea_morphology1.23302254
45MP0001286_abnormal_eye_development1.21565142
46MP0000428_abnormal_craniofacial_morphol1.19730561
47MP0000383_abnormal_hair_follicle1.19571129
48MP0003935_abnormal_craniofacial_develop1.18888285
49MP0000778_abnormal_nervous_system1.18754533
50MP0005164_abnormal_response_to1.16348505
51MP0003755_abnormal_palate_morphology1.14217939
52MP0009115_abnormal_fat_cell1.12798550
53MP0010368_abnormal_lymphatic_system1.12545504
54MP0006138_congestive_heart_failure1.11732053
55MP0004742_abnormal_vestibular_system1.11535874
56MP0010030_abnormal_orbit_morphology1.11459842
57MP0010352_gastrointestinal_tract_polyps1.10961386
58MP0003115_abnormal_respiratory_system1.09442508
59MP0002925_abnormal_cardiovascular_devel1.08850103
60MP0004134_abnormal_chest_morphology1.06937846
61MP0002896_abnormal_bone_mineralization1.06291550
62MP0000647_abnormal_sebaceous_gland1.05612325
63MP0005508_abnormal_skeleton_morphology1.05274154
64MP0005409_darkened_coat_color1.03032808
65MP0002108_abnormal_muscle_morphology1.00685385
66MP0002735_abnormal_chemical_nociception0.99537440
67MP0002116_abnormal_craniofacial_bone0.99415914
68MP0010386_abnormal_urinary_bladder0.98820354
69MP0004484_altered_response_of0.98062457
70MP0001324_abnormal_eye_pigmentation0.97031309
71MP0002102_abnormal_ear_morphology0.94448001
72MP0000230_abnormal_systemic_arterial0.92840865
73MP0001614_abnormal_blood_vessel0.92308486
74MP0002697_abnormal_eye_size0.91540460
75MP0005275_abnormal_skin_tensile0.90922325
76MP0002277_abnormal_respiratory_mucosa0.90922131
77MP0000432_abnormal_head_morphology0.90884772
78MP0003890_abnormal_embryonic-extraembry0.90132251
79MP0003045_fibrosis0.90004640
80MP0000733_abnormal_muscle_development0.89805084
81MP0000371_diluted_coat_color0.88810480
82MP0005257_abnormal_intraocular_pressure0.84071340
83MP0002168_other_aberrant_phenotype0.83446225
84MP0005423_abnormal_somatic_nervous0.83361275
85MP0004130_abnormal_muscle_cell0.82458896
86MP0000026_abnormal_inner_ear0.79495276
87MP0003941_abnormal_skin_development0.77751412
88MP0001851_eye_inflammation0.77050199
89MP0002928_abnormal_bile_duct0.76891543
90MP0005390_skeleton_phenotype0.75771217
91MP0003943_abnormal_hepatobiliary_system0.74041677
92MP0005388_respiratory_system_phenotype0.72090322
93MP0002133_abnormal_respiratory_system0.72090322
94MP0006072_abnormal_retinal_apoptosis0.71381821
95MP0001299_abnormal_eye_distance/0.70422200
96MP0002081_perinatal_lethality0.70133804
97MP0003183_abnormal_peptide_metabolism0.69069356
98MP0004043_abnormal_pH_regulation0.68976692
99MP0002115_abnormal_skeleton_extremities0.68651434
100MP0000470_abnormal_stomach_morphology0.68547493

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.46530152
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.46530152
3Morphological abnormality of the middle ear (HP:0008609)3.41620113
4Aortic aneurysm (HP:0004942)3.38811950
5Short 1st metacarpal (HP:0010034)3.23992173
6Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.23992173
7Genetic anticipation (HP:0003743)3.05876000
8Abnormality of the 1st metacarpal (HP:0010009)2.87367525
9Abnormality of the nasal septum (HP:0000419)2.57444470
10Abnormality of the 4th metacarpal (HP:0010012)2.56665735
11Progressive cerebellar ataxia (HP:0002073)2.56415287
12Hyperventilation (HP:0002883)2.54043775
13Short phalanx of the thumb (HP:0009660)2.53832414
14Aplasia of the musculature (HP:0100854)2.52591028
15Abnormality of the ischium (HP:0003174)2.48447835
16Midline defect of the nose (HP:0004122)2.46414765
17Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.41931600
18Aqueductal stenosis (HP:0002410)2.41264613
19Hypoplastic ischia (HP:0003175)2.40632219
20Hemiplegia (HP:0002301)2.35938959
21Absent frontal sinuses (HP:0002688)2.34646400
22Aplasia/Hypoplasia of the scapulae (HP:0006713)2.32989747
23Hypoplastic scapulae (HP:0000882)2.32989747
24Vertebral arch anomaly (HP:0008438)2.32436523
25Abnormality of the 2nd finger (HP:0004100)2.30112479
26Increased number of teeth (HP:0011069)2.28891196
27Wide anterior fontanel (HP:0000260)2.26130239
28Syringomyelia (HP:0003396)2.23591805
29Spinal cord lesions (HP:0100561)2.23591805
30Neonatal short-limb short stature (HP:0008921)2.23481986
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.22881548
32Absent/shortened dynein arms (HP:0200106)2.22881548
33Abnormality of the axillary hair (HP:0100134)2.20752720
34Abnormality of secondary sexual hair (HP:0009888)2.20752720
35Aortic dissection (HP:0002647)2.19154174
36Broad ribs (HP:0000885)2.18775238
37Coronal craniosynostosis (HP:0004440)2.17866412
38Broad metatarsal (HP:0001783)2.13965534
39Abnormality of the pubic bones (HP:0003172)2.13836481
40Short hallux (HP:0010109)2.11239241
41Aortic regurgitation (HP:0001659)2.09054136
42Tented upper lip vermilion (HP:0010804)2.00336746
43Sparse lateral eyebrow (HP:0005338)1.98180772
44Hypoventilation (HP:0002791)1.96432015
45Shallow orbits (HP:0000586)1.94541834
46Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.93173918
47Fibular hypoplasia (HP:0003038)1.92647313
48Aplasia/Hypoplasia of the hallux (HP:0008362)1.91534022
49Abnormality of incisor morphology (HP:0011063)1.87068596
50Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.86194230
51Biconcave vertebral bodies (HP:0004586)1.85971064
52Heterotopia (HP:0002282)1.85227610
53Focal motor seizures (HP:0011153)1.83723484
54Broad face (HP:0000283)1.82366446
55Chorioretinal atrophy (HP:0000533)1.81221689
56Buphthalmos (HP:0000557)1.79851908
57Hypoplasia of the maxilla (HP:0000327)1.76476823
58Clumsiness (HP:0002312)1.76306299
59Thoracolumbar scoliosis (HP:0002944)1.75659312
60Long eyelashes (HP:0000527)1.74546848
61Shawl scrotum (HP:0000049)1.74263771
62Vitreoretinal degeneration (HP:0000655)1.73524923
63Cutaneous finger syndactyly (HP:0010554)1.73248946
64Aplasia/Hypoplasia of the sternum (HP:0006714)1.71606840
65Choroideremia (HP:0001139)1.71128413
66Bifid scrotum (HP:0000048)1.70919991
67Abnormality of the phalanges of the hallux (HP:0010057)1.69880708
68Abnormality of the sella turcica (HP:0002679)1.69280738
69Genu recurvatum (HP:0002816)1.68438014
70Hypoplastic ilia (HP:0000946)1.67332563
71Hemiparesis (HP:0001269)1.67259062
72Abnormality of the frontal sinuses (HP:0002687)1.66121452
73Benign neoplasm of the central nervous system (HP:0100835)1.65946529
74Hypoplastic nipples (HP:0002557)1.64644464
75Blue sclerae (HP:0000592)1.64380269
76Diastasis recti (HP:0001540)1.64291382
77Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.62666146
78Slender build (HP:0001533)1.61794497
79Abnormality of the right ventricle (HP:0001707)1.59429274
80Limited hip movement (HP:0008800)1.59321812
81Hip contracture (HP:0003273)1.58939920
82Anophthalmia (HP:0000528)1.58162614
83Partial duplication of the phalanx of hand (HP:0009999)1.58028069
84Abnormality of dentin (HP:0010299)1.57591539
85Bicuspid aortic valve (HP:0001647)1.56472475
86Hip dysplasia (HP:0001385)1.56409662
87Spondylolisthesis (HP:0003302)1.56146177
88Abnormal tarsal ossification (HP:0008369)1.55784513
89Flared iliac wings (HP:0002869)1.55783706
90Knee flexion contracture (HP:0006380)1.55739040
91Atonic seizures (HP:0010819)1.55345768
92Overgrowth (HP:0001548)1.53493484
93Mitral stenosis (HP:0001718)1.53404399
94Truncal obesity (HP:0001956)1.50898647
95Laryngomalacia (HP:0001601)1.50832761
96Irregular vertebral endplates (HP:0003301)1.50595665
97Mitral valve prolapse (HP:0001634)1.50166182
98Round face (HP:0000311)1.50164130
99Flat acetabular roof (HP:0003180)1.49928608
100Hypoplastic iliac wings (HP:0002866)1.49326907

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK7.22940262
2AKT35.55106163
3INSRR3.65008189
4MAPK153.29791680
5WEE12.60702539
6MKNK22.27058487
7CAMK1G2.18951351
8WNK11.95139479
9STK391.90549906
10PRKD21.86786220
11CAMK1D1.79139072
12WNK41.71003361
13TRIB31.66147965
14STK38L1.62921082
15MYLK1.59354491
16CDK121.47220148
17IRAK41.36735266
18EPHA41.33030943
19BLK1.24905937
20PDGFRA1.22981635
21DYRK31.21341578
22PAK21.21118830
23TTN1.20824707
24FRK1.14711377
25EPHB21.11190374
26LATS11.11144484
27TNIK1.10606214
28PDGFRB1.07524956
29ERBB41.07462568
30MKNK11.04011616
31STK380.94538720
32IRAK10.92841619
33PTK2B0.91293318
34DDR20.87202427
35SGK20.86684304
36IRAK30.84784433
37CHUK0.84749562
38IRAK20.82941901
39HIPK20.82615855
40LATS20.82211795
41NEK60.80351924
42MTOR0.77632151
43PKN20.76180805
44YES10.75047274
45BMPR1B0.72734217
46ERBB20.71901616
47KIT0.71851532
48MAP3K40.70448438
49CAMK40.69892155
50GSK3A0.69082586
51MAPK70.66524009
52MELK0.66460372
53MAP3K100.66209547
54PRKD10.63443814
55BRD40.62533237
56MAP2K20.62318030
57MATK0.60465288
58SIK10.59612430
59NLK0.58301547
60RPS6KA60.56655785
61ADRBK10.55852386
62NTRK10.55373193
63DMPK0.54088407
64STK240.54037741
65MAP2K10.53292450
66BUB10.52570996
67VRK10.52194401
68NEK90.51063702
69SIK20.50493295
70RPS6KC10.50436698
71RPS6KL10.50436698
72PIK3CA0.49862359
73EPHA30.47122888
74EPHB10.46279942
75SGK30.45482366
76GRK60.44843279
77ZAP700.41948009
78ACVR1B0.41176035
79CDK80.40997254
80TRPM70.40918776
81PAK30.40280078
82MAP2K30.39852554
83CDK30.39725670
84PRKCG0.39315833
85RPS6KA20.39032775
86MAPK40.38507633
87PRKCE0.37821429
88DYRK1B0.37447833
89ICK0.36931523
90CAMK10.36450706
91BRSK20.35590777
92MAPK80.35556142
93RPS6KA10.35085388
94SGK4940.34113211
95SGK2230.34113211
96WNK30.32609902
97JAK10.31921798
98TRIM280.31888537
99PRKCH0.31297160
100MAP3K70.30964536

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.86023466
2TGF-beta signaling pathway_Homo sapiens_hsa043502.04992552
3Dorso-ventral axis formation_Homo sapiens_hsa043201.92907691
4NOD-like receptor signaling pathway_Homo sapiens_hsa046211.55587827
5Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.53315819
6Prostate cancer_Homo sapiens_hsa052151.51269947
7AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.41669745
8Osteoclast differentiation_Homo sapiens_hsa043801.38095166
9MicroRNAs in cancer_Homo sapiens_hsa052061.33584450
10Estrogen signaling pathway_Homo sapiens_hsa049151.33116468
11Notch signaling pathway_Homo sapiens_hsa043301.31361572
12Malaria_Homo sapiens_hsa051441.25607515
13Leishmaniasis_Homo sapiens_hsa051401.22023625
14Gap junction_Homo sapiens_hsa045401.19890084
15ECM-receptor interaction_Homo sapiens_hsa045121.18889150
16Cocaine addiction_Homo sapiens_hsa050301.18874408
17Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18005086
18TNF signaling pathway_Homo sapiens_hsa046681.17594719
19Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17363226
20Focal adhesion_Homo sapiens_hsa045101.16666307
21Amoebiasis_Homo sapiens_hsa051461.15047537
22Renal cell carcinoma_Homo sapiens_hsa052111.14196514
23Phospholipase D signaling pathway_Homo sapiens_hsa040721.13703837
24Legionellosis_Homo sapiens_hsa051341.10872176
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10203065
26cAMP signaling pathway_Homo sapiens_hsa040241.07740943
27FoxO signaling pathway_Homo sapiens_hsa040681.07293429
28Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.05996391
29Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05982643
30Calcium signaling pathway_Homo sapiens_hsa040201.05439438
31Hippo signaling pathway_Homo sapiens_hsa043901.05067679
32Nicotine addiction_Homo sapiens_hsa050331.03374616
33cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01195848
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00263391
35MAPK signaling pathway_Homo sapiens_hsa040100.99958982
36Proteoglycans in cancer_Homo sapiens_hsa052050.99933612
37Dilated cardiomyopathy_Homo sapiens_hsa054140.99806778
38Vascular smooth muscle contraction_Homo sapiens_hsa042700.99542332
39Renin secretion_Homo sapiens_hsa049240.98303371
40Chronic myeloid leukemia_Homo sapiens_hsa052200.98098429
41Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97885930
42Taste transduction_Homo sapiens_hsa047420.95468892
43Pathways in cancer_Homo sapiens_hsa052000.94105378
44Melanoma_Homo sapiens_hsa052180.93129840
45Type II diabetes mellitus_Homo sapiens_hsa049300.93113560
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92779776
47Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91359643
48Hepatitis B_Homo sapiens_hsa051610.90996995
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90297537
50Axon guidance_Homo sapiens_hsa043600.88173166
51Platelet activation_Homo sapiens_hsa046110.87968219
52Toxoplasmosis_Homo sapiens_hsa051450.87192822
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86760604
54Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86581557
55Basal cell carcinoma_Homo sapiens_hsa052170.86397797
56Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85654397
57Choline metabolism in cancer_Homo sapiens_hsa052310.85220278
58Colorectal cancer_Homo sapiens_hsa052100.84273576
59Glutamatergic synapse_Homo sapiens_hsa047240.83136848
60Cholinergic synapse_Homo sapiens_hsa047250.83014904
61Small cell lung cancer_Homo sapiens_hsa052220.82965638
62ErbB signaling pathway_Homo sapiens_hsa040120.80180396
63Wnt signaling pathway_Homo sapiens_hsa043100.78941050
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77726295
65Rap1 signaling pathway_Homo sapiens_hsa040150.76953441
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.76880711
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76155158
68Amphetamine addiction_Homo sapiens_hsa050310.75879729
69Adherens junction_Homo sapiens_hsa045200.74237223
70Hedgehog signaling pathway_Homo sapiens_hsa043400.73186185
71GnRH signaling pathway_Homo sapiens_hsa049120.71488871
72GABAergic synapse_Homo sapiens_hsa047270.71002199
73Melanogenesis_Homo sapiens_hsa049160.70435149
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.70360263
75PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70246431
76Tuberculosis_Homo sapiens_hsa051520.69878143
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69609100
78Morphine addiction_Homo sapiens_hsa050320.69271123
79Thyroid hormone synthesis_Homo sapiens_hsa049180.69263545
80Influenza A_Homo sapiens_hsa051640.68796949
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68135352
82Long-term depression_Homo sapiens_hsa047300.68117217
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.67196080
84Acute myeloid leukemia_Homo sapiens_hsa052210.66939560
85Glioma_Homo sapiens_hsa052140.66743502
86Protein digestion and absorption_Homo sapiens_hsa049740.66470798
87Bladder cancer_Homo sapiens_hsa052190.65662593
88Insulin resistance_Homo sapiens_hsa049310.65019094
89Salivary secretion_Homo sapiens_hsa049700.64938742
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64715039
91Circadian entrainment_Homo sapiens_hsa047130.64601809
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64572904
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64433471
94B cell receptor signaling pathway_Homo sapiens_hsa046620.63649344
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63474903
96Prolactin signaling pathway_Homo sapiens_hsa049170.62928926
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62110488
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.61387382
99Pertussis_Homo sapiens_hsa051330.60255423
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59630128

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