C9ORF43

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aggressive behavior (GO:0002118)6.52953550
2piRNA metabolic process (GO:0034587)6.12498854
3regulation of female receptivity (GO:0045924)5.59422931
4female mating behavior (GO:0060180)5.52711983
5cell wall macromolecule catabolic process (GO:0016998)5.44597055
6DNA methylation involved in gamete generation (GO:0043046)5.00366380
7cell wall macromolecule metabolic process (GO:0044036)4.83153908
8hyperosmotic salinity response (GO:0042538)4.77474996
9synapsis (GO:0007129)4.72827209
10grooming behavior (GO:0007625)4.65191587
11male meiosis I (GO:0007141)4.64543240
12autophagic vacuole fusion (GO:0000046)4.61901000
13sperm motility (GO:0030317)4.37106690
14seminiferous tubule development (GO:0072520)4.34232184
15rRNA modification (GO:0000154)4.20471321
16pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.99961015
17regulation of meiosis I (GO:0060631)3.86313310
18chromosome organization involved in meiosis (GO:0070192)3.82217930
19male meiosis (GO:0007140)3.78263737
20rRNA methylation (GO:0031167)3.77446445
21spermatid development (GO:0007286)3.75843617
22organelle membrane fusion (GO:0090174)3.75621645
23meiosis I (GO:0007127)3.67826567
24base-excision repair, AP site formation (GO:0006285)3.60914368
25sperm-egg recognition (GO:0035036)3.58690777
26single strand break repair (GO:0000012)3.57789186
27positive regulation of prostaglandin secretion (GO:0032308)3.56163113
28acrosome reaction (GO:0007340)3.53839591
29purine deoxyribonucleotide catabolic process (GO:0009155)3.47017786
30synaptonemal complex assembly (GO:0007130)3.46217662
31deoxyribonucleotide catabolic process (GO:0009264)3.45482383
32positive regulation of B cell differentiation (GO:0045579)3.42343200
33regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.42074927
34definitive hemopoiesis (GO:0060216)3.39052631
35binding of sperm to zona pellucida (GO:0007339)3.35794564
36ribosomal small subunit assembly (GO:0000028)3.35516035
37deoxyribose phosphate catabolic process (GO:0046386)3.30466517
38regulation of histone H3-K9 methylation (GO:0051570)3.30176555
39protein polyglutamylation (GO:0018095)3.26736589
40response to pheromone (GO:0019236)3.18727027
41fusion of sperm to egg plasma membrane (GO:0007342)3.18587740
42deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.14971010
43maternal behavior (GO:0042711)3.11148147
44protein complex biogenesis (GO:0070271)3.10246995
45endothelium development (GO:0003158)3.09109819
46multicellular organism reproduction (GO:0032504)3.08981841
47synaptonemal complex organization (GO:0070193)3.06013748
48drinking behavior (GO:0042756)3.02306530
49RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.01911159
50tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.01911159
51meiotic nuclear division (GO:0007126)3.01798198
52cellular response to exogenous dsRNA (GO:0071360)2.95647058
53pyrimidine nucleotide catabolic process (GO:0006244)2.92020725
54purine deoxyribonucleotide metabolic process (GO:0009151)2.88682808
55RNA methylation (GO:0001510)2.88228488
56purine nucleotide salvage (GO:0032261)2.88208777
57mitochondrial respiratory chain complex assembly (GO:0033108)2.87964700
58regulation of B cell apoptotic process (GO:0002902)2.85615733
59parental behavior (GO:0060746)2.85502672
60centriole replication (GO:0007099)2.83730153
61negative regulation of digestive system process (GO:0060457)2.82580490
62DNA synthesis involved in DNA repair (GO:0000731)2.82106214
63branched-chain amino acid catabolic process (GO:0009083)2.81879100
64estrogen biosynthetic process (GO:0006703)2.81288725
65cell-cell recognition (GO:0009988)2.80914635
66cellular ketone body metabolic process (GO:0046950)2.80114813
67fertilization (GO:0009566)2.79277087
68mitochondrial respiratory chain complex I assembly (GO:0032981)2.78386868
69NADH dehydrogenase complex assembly (GO:0010257)2.78386868
70mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.78386868
712-deoxyribonucleotide metabolic process (GO:0009394)2.75138347
72DNA deamination (GO:0045006)2.74312411
73cell differentiation involved in metanephros development (GO:0072202)2.73874379
74regulation of penile erection (GO:0060405)2.73103790
75negative regulation of B cell apoptotic process (GO:0002903)2.71718685
76nucleotide salvage (GO:0043173)2.69223183
77immunoglobulin mediated immune response (GO:0016064)2.68333075
78ubiquinone biosynthetic process (GO:0006744)2.67857718
79reproduction (GO:0000003)2.67010597
80heparin metabolic process (GO:0030202)2.66031751
81heparin biosynthetic process (GO:0030210)2.66031751
82branched-chain amino acid metabolic process (GO:0009081)2.64386622
83negative regulation of telomere maintenance (GO:0032205)2.63605437
84regulation of prostaglandin secretion (GO:0032306)2.63198420
85peroxisome fission (GO:0016559)2.61867627
86hematopoietic stem cell proliferation (GO:0071425)2.61698298
87mannosylation (GO:0097502)2.61293104
88sleep (GO:0030431)2.60862239
89ketone body metabolic process (GO:1902224)2.60508609
90plasma membrane fusion (GO:0045026)2.60364282
91pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.58468242
92NAD biosynthetic process (GO:0009435)2.58254685
93mismatch repair (GO:0006298)2.57011344
94epithelial cilium movement (GO:0003351)2.56875831
95deoxyribose phosphate metabolic process (GO:0019692)2.55968635
96spermatogenesis (GO:0007283)2.55349928
97male gamete generation (GO:0048232)2.54776480
98meiotic cell cycle process (GO:1903046)2.53620943
99sperm capacitation (GO:0048240)2.52790086
100positive regulation of vasculogenesis (GO:2001214)2.52434325

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.56087533
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.73389424
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.58132320
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.21268722
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.09548731
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.92112577
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.71936032
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.69703360
9SCL_19346495_ChIP-Seq_HPC-7_Human2.62610574
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.61559961
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.60042658
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.51019267
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.45196196
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.39412650
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.30778357
16ZNF274_21170338_ChIP-Seq_K562_Hela2.30282252
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.29633699
18VDR_23849224_ChIP-Seq_CD4+_Human2.25945090
19* FOXP3_21729870_ChIP-Seq_TREG_Human2.15723711
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.10741145
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.00812576
22MYC_18358816_ChIP-ChIP_MESCs_Mouse1.96419991
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.92837403
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.82457536
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.81572322
26VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.77156931
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76284281
28CIITA_25753668_ChIP-Seq_RAJI_Human1.73292330
29* ELF1_20517297_ChIP-Seq_JURKAT_Human1.69579465
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.69263883
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.65964928
32CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.63497280
33BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.63490394
34FUS_26573619_Chip-Seq_HEK293_Human1.63153778
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60339273
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59697326
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53756755
38YY1_22570637_ChIP-Seq_MALME-3M_Human1.50687711
39* BCL6_27268052_Chip-Seq_Bcells_Human1.48843275
40* TTF2_22483619_ChIP-Seq_HELA_Human1.48789897
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47496878
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42718559
43GABP_19822575_ChIP-Seq_HepG2_Human1.42473292
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.41739898
45ERG_20517297_ChIP-Seq_VCAP_Human1.41582442
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40939741
47ELK1_19687146_ChIP-ChIP_HELA_Human1.36777697
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36255151
49* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.35036657
50EGR1_23403033_ChIP-Seq_LIVER_Mouse1.34709099
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.33887394
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.33083495
53MYB_26560356_Chip-Seq_TH2_Human1.30394500
54CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.29932937
55ESR1_15608294_ChIP-ChIP_MCF-7_Human1.28977496
56* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.27435812
57CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26448887
58KDM5A_27292631_Chip-Seq_BREAST_Human1.25780342
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.25378234
60MYC_18940864_ChIP-ChIP_HL60_Human1.25098593
61ERA_21632823_ChIP-Seq_H3396_Human1.23945169
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23901965
63* P300_27268052_Chip-Seq_Bcells_Human1.22597530
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22547881
65MYC_19030024_ChIP-ChIP_MESCs_Mouse1.22535345
66NANOG_20526341_ChIP-Seq_ESCs_Human1.21930347
67STAT1_20625510_ChIP-Seq_HELA_Human1.21655995
68E2F1_20622854_ChIP-Seq_HELA_Human1.21257913
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20056862
70XRN2_22483619_ChIP-Seq_HELA_Human1.18545527
71AR_20517297_ChIP-Seq_VCAP_Human1.18545120
72FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17488869
73SPI1_23547873_ChIP-Seq_NB4_Human1.16575735
74E2F7_22180533_ChIP-Seq_HELA_Human1.12693622
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.11073449
76PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08813227
77RAC3_21632823_ChIP-Seq_H3396_Human1.08796809
78E2F4_17652178_ChIP-ChIP_JURKAT_Human1.05255941
79LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.03714590
80IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02532744
81ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01857068
82VDR_21846776_ChIP-Seq_THP-1_Human1.00420737
83FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99991991
84FOXA1_25329375_ChIP-Seq_VCAP_Human0.99991991
85PHF8_20622854_ChIP-Seq_HELA_Human0.99120788
86MYC_19079543_ChIP-ChIP_MESCs_Mouse0.98514524
87* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98066940
88P68_20966046_ChIP-Seq_HELA_Human0.97954324
89P53_21459846_ChIP-Seq_SAOS-2_Human0.97885861
90FOXP1_21924763_ChIP-Seq_HESCs_Human0.97243056
91GATA3_26560356_Chip-Seq_TH2_Human0.97194674
92EWS_26573619_Chip-Seq_HEK293_Human0.95080891
93ER_23166858_ChIP-Seq_MCF-7_Human0.94310604
94* BCOR_27268052_Chip-Seq_Bcells_Human0.94250539
95ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93746839
96TAF2_19829295_ChIP-Seq_ESCs_Human0.93199046
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92961732
98MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92114270
99* SPI1_20517297_ChIP-Seq_HL60_Human0.92099319
100RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91546327

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.52844193
2MP0003718_maternal_effect3.83013337
3MP0008058_abnormal_DNA_repair3.79853906
4MP0008877_abnormal_DNA_methylation3.67852161
5MP0003806_abnormal_nucleotide_metabolis3.31990785
6MP0001929_abnormal_gametogenesis2.58570510
7MP0005646_abnormal_pituitary_gland2.55553963
8MP0003698_abnormal_male_reproductive2.40368419
9MP0005084_abnormal_gallbladder_morpholo2.36540100
10MP0002160_abnormal_reproductive_system2.27431793
11MP0005075_abnormal_melanosome_morpholog2.15878898
12MP0005645_abnormal_hypothalamus_physiol2.10542868
13MP0006292_abnormal_olfactory_placode2.10536212
14MP0005464_abnormal_platelet_physiology2.09179837
15MP0006036_abnormal_mitochondrial_physio2.08341873
16MP0002138_abnormal_hepatobiliary_system2.05887151
17MP0009697_abnormal_copulation2.05472360
18MP0005397_hematopoietic_system_phenotyp1.99484386
19MP0001545_abnormal_hematopoietic_system1.99484386
20MP0005670_abnormal_white_adipose1.99407208
21MP0005220_abnormal_exocrine_pancreas1.98294179
22MP0002396_abnormal_hematopoietic_system1.88821553
23MP0003172_abnormal_lysosome_physiology1.88683266
24MP0001145_abnormal_male_reproductive1.82893092
25MP0002210_abnormal_sex_determination1.80921023
26MP0000681_abnormal_thyroid_gland1.79618916
27MP0000653_abnormal_sex_gland1.77316637
28MP0002132_abnormal_respiratory_system1.70889030
29MP0001835_abnormal_antigen_presentation1.70653546
30MP0006276_abnormal_autonomic_nervous1.66702977
31MP0010094_abnormal_chromosome_stability1.64708216
32MP0009278_abnormal_bone_marrow1.59602083
33MP0003252_abnormal_bile_duct1.59360253
34MP0000372_irregular_coat_pigmentation1.57037610
35MP0001764_abnormal_homeostasis1.55843294
36MP0000015_abnormal_ear_pigmentation1.47569525
37MP0004808_abnormal_hematopoietic_stem1.45656857
38MP0002139_abnormal_hepatobiliary_system1.36511176
39MP0008875_abnormal_xenobiotic_pharmacok1.34023164
40MP0000678_abnormal_parathyroid_gland1.30551386
41MP0002161_abnormal_fertility/fecundity1.29572963
42MP0003787_abnormal_imprinting1.28379953
43MP0008995_early_reproductive_senescence1.28147863
44MP0005389_reproductive_system_phenotype1.27879745
45MP0005395_other_phenotype1.27539911
46MP0003786_premature_aging1.23099980
47MP0003186_abnormal_redox_activity1.23042001
48MP0006072_abnormal_retinal_apoptosis1.22592987
49MP0010368_abnormal_lymphatic_system1.18823407
50MP0003111_abnormal_nucleus_morphology1.15018717
51MP0003303_peritoneal_inflammation1.14254545
52MP0002148_abnormal_hypersensitivity_rea1.13717948
53MP0005058_abnormal_lysosome_morphology1.12667203
54MP0001968_abnormal_touch/_nociception1.11777677
55MP0009379_abnormal_foot_pigmentation1.10254724
56MP0005174_abnormal_tail_pigmentation1.08838673
57MP0004147_increased_porphyrin_level1.08711575
58MP0001119_abnormal_female_reproductive1.07500858
59MP0008007_abnormal_cellular_replicative1.05174383
60MP0005551_abnormal_eye_electrophysiolog1.03035931
61MP0005535_abnormal_body_temperature0.99230898
62MP0003191_abnormal_cellular_cholesterol0.98221959
63MP0005377_hearing/vestibular/ear_phenot0.97255598
64MP0003878_abnormal_ear_physiology0.97255598
65MP0001881_abnormal_mammary_gland0.94173874
66MP0000465_gastrointestinal_hemorrhage0.94036637
67MP0009765_abnormal_xenobiotic_induced0.94021897
68MP0002019_abnormal_tumor_incidence0.91794187
69MP0002095_abnormal_skin_pigmentation0.88992136
70MP0002234_abnormal_pharynx_morphology0.86379569
71MP0003699_abnormal_female_reproductive0.86084784
72MP0008873_increased_physiological_sensi0.85914437
73MP0001986_abnormal_taste_sensitivity0.85052551
74MP0000230_abnormal_systemic_arterial0.82668129
75MP0002928_abnormal_bile_duct0.82646486
76MP0005636_abnormal_mineral_homeostasis0.80785346
77MP0006035_abnormal_mitochondrial_morpho0.77708849
78MP0005266_abnormal_metabolism0.76657341
79MP0000689_abnormal_spleen_morphology0.76505171
80MP0003077_abnormal_cell_cycle0.76152035
81MP0002398_abnormal_bone_marrow0.75473108
82MP0005085_abnormal_gallbladder_physiolo0.74190632
83MP0003693_abnormal_embryo_hatching0.73914487
84MP0003638_abnormal_response/metabolism_0.72908197
85MP0001666_abnormal_nutrient_absorption0.72051480
86MP0005319_abnormal_enzyme/_coenzyme0.70501921
87MP0002971_abnormal_brown_adipose0.69233679
88MP0001905_abnormal_dopamine_level0.69135803
89MP0000569_abnormal_digit_pigmentation0.67339419
90MP0008004_abnormal_stomach_pH0.66101035
91MP0005647_abnormal_sex_gland0.65943036
92MP0002733_abnormal_thermal_nociception0.65890160
93MP0000313_abnormal_cell_death0.65726691
94MP0008469_abnormal_protein_level0.65006635
95MP0002876_abnormal_thyroid_physiology0.64585193
96MP0008872_abnormal_physiological_respon0.64338725
97MP0009643_abnormal_urine_homeostasis0.64132640
98MP0002736_abnormal_nociception_after0.63795396
99MP0003943_abnormal_hepatobiliary_system0.63645095
100MP0001765_abnormal_ion_homeostasis0.63353316

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)4.22595915
2Severe visual impairment (HP:0001141)3.80113610
3Hepatocellular necrosis (HP:0001404)3.67955836
4Tubulointerstitial nephritis (HP:0001970)3.54918778
5Hepatic necrosis (HP:0002605)3.43596175
6Type I transferrin isoform profile (HP:0003642)3.35195934
7Panhypogammaglobulinemia (HP:0003139)3.29556071
8Dynein arm defect of respiratory motile cilia (HP:0012255)3.26861163
9Absent/shortened dynein arms (HP:0200106)3.26861163
10Elevated erythrocyte sedimentation rate (HP:0003565)3.21442110
11Abolished electroretinogram (ERG) (HP:0000550)3.17523051
12Attenuation of retinal blood vessels (HP:0007843)3.16153783
13Hypergonadotropic hypogonadism (HP:0000815)3.13189788
14Agammaglobulinemia (HP:0004432)3.10628587
15Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.96991831
16Abnormal protein N-linked glycosylation (HP:0012347)2.96991831
17Abnormal protein glycosylation (HP:0012346)2.96991831
18Abnormal glycosylation (HP:0012345)2.96991831
19Abnormality of the prostate (HP:0008775)2.77959277
20Mitochondrial inheritance (HP:0001427)2.77397110
21Abnormal biliary tract physiology (HP:0012439)2.72841740
22Bile duct proliferation (HP:0001408)2.72841740
23Pancreatic cysts (HP:0001737)2.72817270
24Nephronophthisis (HP:0000090)2.69594247
25Pancreatic fibrosis (HP:0100732)2.67240670
26Decreased electroretinogram (ERG) amplitude (HP:0000654)2.66183312
27Increased neuronal autofluorescent lipopigment (HP:0002074)2.64391853
28Spontaneous abortion (HP:0005268)2.62519068
29Chronic hepatic failure (HP:0100626)2.61347910
30Abnormal rod and cone electroretinograms (HP:0008323)2.61260212
31Generalized aminoaciduria (HP:0002909)2.58125934
32Renal Fanconi syndrome (HP:0001994)2.54164599
33Increased CSF lactate (HP:0002490)2.51292007
34Abnormal respiratory epithelium morphology (HP:0012253)2.44397637
35Abnormal respiratory motile cilium morphology (HP:0005938)2.44397637
36Brushfield spots (HP:0001088)2.40714945
37Azoospermia (HP:0000027)2.38587541
38Acute lymphatic leukemia (HP:0006721)2.37213380
39Abnormal respiratory motile cilium physiology (HP:0012261)2.37102657
40Chronic otitis media (HP:0000389)2.34779511
41Abnormal spermatogenesis (HP:0008669)2.32338307
42Abnormal ciliary motility (HP:0012262)2.31575728
43Abnormality of fatty-acid metabolism (HP:0004359)2.30251776
44Decreased central vision (HP:0007663)2.30049666
45Abnormality of the renal medulla (HP:0100957)2.27314887
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.27313581
47Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.27313581
48Increased intramyocellular lipid droplets (HP:0012240)2.21580440
49Abnormal number of erythroid precursors (HP:0012131)2.15681177
503-Methylglutaconic aciduria (HP:0003535)2.13041210
51Progressive muscle weakness (HP:0003323)2.12455757
52Bony spicule pigmentary retinopathy (HP:0007737)2.11306504
53Failure to thrive in infancy (HP:0001531)2.09249552
54Increased muscle lipid content (HP:0009058)2.04357947
55Abnormal drinking behavior (HP:0030082)2.03000458
56Polydipsia (HP:0001959)2.03000458
57Supernumerary spleens (HP:0009799)2.02521420
58Abnormality of cells of the erythroid lineage (HP:0012130)2.01312150
59Increased cerebral lipofuscin (HP:0011813)2.01269036
60Increased serum lactate (HP:0002151)2.00507464
61Absent rod-and cone-mediated responses on ERG (HP:0007688)2.00380902
62Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.99838882
63Abnormal mitochondria in muscle tissue (HP:0008316)1.99502113
64Oral leukoplakia (HP:0002745)1.99125914
65B lymphocytopenia (HP:0010976)1.98842960
66Lactic acidosis (HP:0003128)1.96967574
67Congenital hepatic fibrosis (HP:0002612)1.95480833
68Abnormality of macular pigmentation (HP:0008002)1.92101486
69Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91970391
70Cystic liver disease (HP:0006706)1.90573213
71Portal hypertension (HP:0001409)1.89997467
72Abnormality of B cell number (HP:0010975)1.89014644
73Molar tooth sign on MRI (HP:0002419)1.87967454
74Abnormality of midbrain morphology (HP:0002418)1.87967454
75Reduced antithrombin III activity (HP:0001976)1.87941502
76Hypothermia (HP:0002045)1.87449343
77Aplasia/hypoplasia of the uterus (HP:0008684)1.86547547
78Acute necrotizing encephalopathy (HP:0006965)1.86188695
79Infertility (HP:0000789)1.85834359
80Hypoplasia of the uterus (HP:0000013)1.85352732
81Abnormality of the proximal phalanges of the hand (HP:0009834)1.82755170
82Cerebral edema (HP:0002181)1.82657688
83Insulin-resistant diabetes mellitus (HP:0000831)1.81826553
84Abnormality of renal resorption (HP:0011038)1.81286536
85Acute hepatic failure (HP:0006554)1.80985465
86Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.80925974
87Asplenia (HP:0001746)1.79739916
88Absent thumb (HP:0009777)1.79597710
89Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.79469210
90Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.78810899
91Dicarboxylic aciduria (HP:0003215)1.77426375
92Abnormality of dicarboxylic acid metabolism (HP:0010995)1.77426375
93Spastic paraparesis (HP:0002313)1.74762120
94Cerebellar dysplasia (HP:0007033)1.74244459
95Aplastic anemia (HP:0001915)1.73859302
96Abnormality of the hepatic vasculature (HP:0006707)1.73631465
97Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.73194834
98Short 1st metacarpal (HP:0010034)1.73194834
99True hermaphroditism (HP:0010459)1.72916244
100Abnormality of the heme biosynthetic pathway (HP:0010472)1.71665466

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.79070474
2SCYL23.76058439
3TAOK33.61609101
4MAP4K23.42292425
5NUAK13.28799490
6VRK23.06349347
7ZAK2.72444276
8PBK2.68002936
9CDK192.64195429
10FLT32.56644480
11KIT2.33435430
12PINK12.20400338
13TAF12.03213989
14PLK41.94900061
15CSF1R1.92715618
16TESK21.82854493
17EIF2AK31.82514826
18ERN11.69748241
19TLK11.57621875
20CDC71.55658259
21TEC1.52908329
22TBK11.51278661
23NME21.49984207
24MAPKAPK31.42910137
25FES1.40113438
26MAP4K11.36303668
27PNCK1.34411313
28VRK11.29171496
29PIK3CG1.28960220
30STK161.24056470
31KDR1.17766968
32MAP2K31.13182902
33BMPR1B1.10561140
34CCNB11.03979779
35MAP3K111.02623916
36SRPK11.02246199
37RPS6KB21.00946709
38WNK41.00223595
39TNK21.00042452
40SYK0.96571312
41ATR0.94779573
42LATS10.92420733
43MAP2K60.92249570
44TIE10.89024900
45OXSR10.88743192
46STK390.86751897
47IKBKB0.86374404
48MAP2K20.84152523
49INSRR0.82307300
50AURKA0.78882327
51ABL20.77504948
52RPS6KA50.77170516
53DAPK10.76875777
54PDK20.76372669
55CDK90.75163649
56BTK0.74046070
57FRK0.72207183
58CDK70.71716423
59PIM20.71068956
60ITK0.68845927
61ARAF0.64702946
62CHEK20.64540476
63GRK10.62716264
64CDK30.60569846
65BMPR20.60301273
66TESK10.56337298
67MAP3K130.55515249
68RPS6KA40.54596499
69GRK60.53057606
70PLK10.50117698
71MAPKAPK50.48564043
72MAPK110.47115664
73CSNK1G30.46809145
74CSNK2A20.44109609
75ATM0.43712642
76IRAK20.43669685
77JAK30.43187345
78PRKCQ0.42607481
79AURKB0.42433081
80RPS6KA60.41894295
81ADRBK20.41508427
82RPS6KC10.41311666
83RPS6KL10.41311666
84PRKD20.38655284
85IGF1R0.38230868
86CHEK10.37467771
87LYN0.36451681
88CDK40.36305973
89CSNK2A10.35989469
90RPS6KA10.34447923
91CDK20.34259124
92STK380.33983239
93MAPK30.32620581
94PTK2B0.32571131
95ABL10.32537877
96MAPK150.29832071
97CSNK1A10.26536184
98HCK0.24898771
99CSNK1G20.24369427
100GRK70.24311486

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.64292855
2Allograft rejection_Homo sapiens_hsa053302.85809515
3Base excision repair_Homo sapiens_hsa034102.82119709
4Ribosome_Homo sapiens_hsa030102.74073654
5Type I diabetes mellitus_Homo sapiens_hsa049402.62941955
6Autoimmune thyroid disease_Homo sapiens_hsa053202.57099339
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.50592395
8Graft-versus-host disease_Homo sapiens_hsa053322.44323467
9Homologous recombination_Homo sapiens_hsa034402.39960119
10Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.05282053
11DNA replication_Homo sapiens_hsa030302.03386046
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.86481724
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.83305331
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.78038452
15RNA transport_Homo sapiens_hsa030131.71003304
16Peroxisome_Homo sapiens_hsa041461.70765243
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.68906336
18Antigen processing and presentation_Homo sapiens_hsa046121.68450428
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60800457
20Fanconi anemia pathway_Homo sapiens_hsa034601.60505677
21Pyrimidine metabolism_Homo sapiens_hsa002401.55954873
22Selenocompound metabolism_Homo sapiens_hsa004501.52487491
23RNA polymerase_Homo sapiens_hsa030201.50775465
24Oxidative phosphorylation_Homo sapiens_hsa001901.48355489
25Systemic lupus erythematosus_Homo sapiens_hsa053221.44963885
26Parkinsons disease_Homo sapiens_hsa050121.41124741
27Non-homologous end-joining_Homo sapiens_hsa034501.35586104
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33764979
29Fatty acid elongation_Homo sapiens_hsa000621.33649078
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33500978
31Mismatch repair_Homo sapiens_hsa034301.32254993
32Olfactory transduction_Homo sapiens_hsa047401.31726494
33Purine metabolism_Homo sapiens_hsa002301.30497423
34Butanoate metabolism_Homo sapiens_hsa006501.30008294
35Proteasome_Homo sapiens_hsa030501.27886498
36Propanoate metabolism_Homo sapiens_hsa006401.23049375
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.20955157
38Spliceosome_Homo sapiens_hsa030401.17855117
39Other glycan degradation_Homo sapiens_hsa005111.16679209
40Rheumatoid arthritis_Homo sapiens_hsa053231.15427522
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.14336382
42RNA degradation_Homo sapiens_hsa030181.11239988
43Primary immunodeficiency_Homo sapiens_hsa053401.11089742
44Nucleotide excision repair_Homo sapiens_hsa034201.10439025
45Basal transcription factors_Homo sapiens_hsa030221.07520862
46Herpes simplex infection_Homo sapiens_hsa051681.05718836
47Tryptophan metabolism_Homo sapiens_hsa003801.01330397
48Huntingtons disease_Homo sapiens_hsa050161.00460649
49Staphylococcus aureus infection_Homo sapiens_hsa051500.99552549
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98212976
51Linoleic acid metabolism_Homo sapiens_hsa005910.98117298
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96941784
53Glutathione metabolism_Homo sapiens_hsa004800.95033970
54Arachidonic acid metabolism_Homo sapiens_hsa005900.93360670
55Sulfur metabolism_Homo sapiens_hsa009200.90149367
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.90003430
57Viral myocarditis_Homo sapiens_hsa054160.88497143
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86105911
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84920996
60Fatty acid metabolism_Homo sapiens_hsa012120.82366360
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81311572
62Chemical carcinogenesis_Homo sapiens_hsa052040.80291935
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80049233
64Leishmaniasis_Homo sapiens_hsa051400.79414827
65Fatty acid degradation_Homo sapiens_hsa000710.78697012
66Regulation of autophagy_Homo sapiens_hsa041400.77727278
67Phototransduction_Homo sapiens_hsa047440.75655226
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74395888
69Fatty acid biosynthesis_Homo sapiens_hsa000610.70038990
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70036502
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69848319
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69413781
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.69130249
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.69113862
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.68489946
76Metabolic pathways_Homo sapiens_hsa011000.67897872
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.67717019
78Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65882171
79Tyrosine metabolism_Homo sapiens_hsa003500.64089841
80Pyruvate metabolism_Homo sapiens_hsa006200.57864424
81Influenza A_Homo sapiens_hsa051640.53618793
82Pentose phosphate pathway_Homo sapiens_hsa000300.52977226
83Taste transduction_Homo sapiens_hsa047420.52608757
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52064236
85Salivary secretion_Homo sapiens_hsa049700.50810198
86Platelet activation_Homo sapiens_hsa046110.48047392
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45516202
88Ether lipid metabolism_Homo sapiens_hsa005650.45491319
89Retinol metabolism_Homo sapiens_hsa008300.44185346
90One carbon pool by folate_Homo sapiens_hsa006700.43621191
91Glycerolipid metabolism_Homo sapiens_hsa005610.43433496
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43121670
93Carbon metabolism_Homo sapiens_hsa012000.42619287
94Alzheimers disease_Homo sapiens_hsa050100.41405683
95beta-Alanine metabolism_Homo sapiens_hsa004100.37845514
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37011669
97Hematopoietic cell lineage_Homo sapiens_hsa046400.35831340
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33042273
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31792765
100Renin-angiotensin system_Homo sapiens_hsa046140.30798678

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