C9ORF16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.98347814
2pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.20024078
3GDP-mannose metabolic process (GO:0019673)4.01909685
4deoxyribose phosphate biosynthetic process (GO:0046385)3.89804205
52-deoxyribonucleotide biosynthetic process (GO:0009265)3.89804205
6deoxyribonucleotide catabolic process (GO:0009264)3.83861692
7purine deoxyribonucleotide catabolic process (GO:0009155)3.79400931
8chaperone-mediated protein transport (GO:0072321)3.75524556
9iron-sulfur cluster assembly (GO:0016226)3.69219794
10metallo-sulfur cluster assembly (GO:0031163)3.69219794
11Arp2/3 complex-mediated actin nucleation (GO:0034314)3.66416238
12protein neddylation (GO:0045116)3.61724933
13autophagic vacuole fusion (GO:0000046)3.59967315
14deoxyribose phosphate catabolic process (GO:0046386)3.53584590
15synaptic vesicle maturation (GO:0016188)3.49169164
16neutrophil activation involved in immune response (GO:0002283)3.40216938
17pyrimidine nucleotide catabolic process (GO:0006244)3.40161373
18negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.40124773
19lipoxygenase pathway (GO:0019372)3.39271153
20pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.36601111
21synaptic vesicle exocytosis (GO:0016079)3.34416089
22mitochondrial calcium ion transport (GO:0006851)3.31940861
232-deoxyribonucleotide metabolic process (GO:0009394)3.30664605
24energy coupled proton transport, down electrochemical gradient (GO:0015985)3.29607881
25ATP synthesis coupled proton transport (GO:0015986)3.29607881
26purine deoxyribonucleotide metabolic process (GO:0009151)3.25841193
27respiratory electron transport chain (GO:0022904)3.15102997
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.12615299
29base-excision repair, AP site formation (GO:0006285)3.11234063
30purine nucleotide salvage (GO:0032261)3.10807716
31electron transport chain (GO:0022900)3.10767792
32protein maturation by protein folding (GO:0022417)3.09149451
33deoxyribose phosphate metabolic process (GO:0019692)3.07502572
34negative regulation of erythrocyte differentiation (GO:0045647)3.02753056
35nucleotide salvage (GO:0043173)2.99349974
36protein insertion into membrane (GO:0051205)2.96995118
37protein complex biogenesis (GO:0070271)2.95198021
38GMP metabolic process (GO:0046037)2.94362142
39mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.93919979
40actin nucleation (GO:0045010)2.93912902
41viral protein processing (GO:0019082)2.93345535
42ribosomal small subunit assembly (GO:0000028)2.77977481
43polyamine biosynthetic process (GO:0006596)2.77974348
44viral transcription (GO:0019083)2.77655886
45DNA deamination (GO:0045006)2.76929728
46mitochondrial respiratory chain complex I assembly (GO:0032981)2.76200591
47NADH dehydrogenase complex assembly (GO:0010257)2.76200591
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.76200591
49negative regulation of B cell apoptotic process (GO:0002903)2.76019728
50guanosine-containing compound biosynthetic process (GO:1901070)2.75723562
51oxygen transport (GO:0015671)2.74838844
52energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.72095265
53ATP hydrolysis coupled proton transport (GO:0015991)2.72095265
54response to misfolded protein (GO:0051788)2.70531777
55prostaglandin biosynthetic process (GO:0001516)2.70242386
56prostanoid biosynthetic process (GO:0046457)2.70242386
57ribosomal small subunit biogenesis (GO:0042274)2.69966473
58deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.67550482
59mature B cell differentiation involved in immune response (GO:0002313)2.65449473
60adenosine receptor signaling pathway (GO:0001973)2.64550935
61female mating behavior (GO:0060180)2.63124336
62regulation of synaptic vesicle exocytosis (GO:2000300)2.62362041
63modulation by virus of host process (GO:0019054)2.61906035
64mitochondrial respiratory chain complex assembly (GO:0033108)2.60716355
65purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.60590946
66phagosome maturation (GO:0090382)2.56870058
67positive regulation of TOR signaling (GO:0032008)2.55524333
68negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.54654610
69deoxyribonucleotide metabolic process (GO:0009262)2.54640137
70organelle membrane fusion (GO:0090174)2.52433136
71virion assembly (GO:0019068)2.49367972
72sequestering of actin monomers (GO:0042989)2.48333325
73negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.47467522
74translational termination (GO:0006415)2.47106362
75positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.45872069
76positive regulation of B cell differentiation (GO:0045579)2.45233427
77translational elongation (GO:0006414)2.45201996
78negative regulation of DNA-templated transcription, elongation (GO:0032785)2.43478154
79positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.42809538
80glutamate secretion (GO:0014047)2.42216942
81regulation of release of cytochrome c from mitochondria (GO:0090199)2.42160788
82pentose metabolic process (GO:0019321)2.40842170
83positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.40546244
84deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.40173757
85regulation of mitochondrial membrane potential (GO:0051881)2.39110083
86oxidative phosphorylation (GO:0006119)2.37883155
87mitochondrial calcium ion homeostasis (GO:0051560)2.37147536
88regulation of female receptivity (GO:0045924)2.36759529
89regulation of dopamine metabolic process (GO:0042053)2.36090582
90regulation of catecholamine metabolic process (GO:0042069)2.36090582
91regulation of synaptic vesicle transport (GO:1902803)2.35915234
92negative regulation of cation channel activity (GO:2001258)2.33472976
93pyrimidine nucleoside salvage (GO:0043097)2.31990200
94pyrimidine-containing compound salvage (GO:0008655)2.31990200
95gas transport (GO:0015669)2.31268922
96heme biosynthetic process (GO:0006783)2.31066913
97phosphatidylglycerol biosynthetic process (GO:0006655)2.30923739
98hydrogen ion transmembrane transport (GO:1902600)2.30432263
99UV protection (GO:0009650)2.29391726
100ATP biosynthetic process (GO:0006754)2.29280286

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.32931607
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.44760548
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.40385212
4* LXR_22292898_ChIP-Seq_THP-1_Human2.37998922
5SRY_22984422_ChIP-ChIP_TESTIS_Rat2.37285335
6VDR_21846776_ChIP-Seq_THP-1_Human2.37207434
7RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.36723566
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.32851206
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.30344340
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.25484051
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.21367790
12CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.14748938
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.07752403
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.07427894
15P68_20966046_ChIP-Seq_HELA_Human2.06685854
16BCL6_27268052_Chip-Seq_Bcells_Human2.05723087
17ELF1_20517297_ChIP-Seq_JURKAT_Human2.04444485
18TET1_21451524_ChIP-Seq_MESCs_Mouse2.02380493
19LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.99659307
20CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.98956465
21TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95281891
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.81606747
23MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.78223293
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.77733590
25BCOR_27268052_Chip-Seq_Bcells_Human1.73706740
26TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.72359921
27THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69627784
28SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.63936600
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.63837617
30SCL_19346495_ChIP-Seq_HPC-7_Human1.57661915
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55388478
32SA1_27219007_Chip-Seq_ERYTHROID_Human1.55233084
33SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.51950806
34LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.51077541
35UTX_26944678_Chip-Seq_JUKART_Human1.50431125
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.50033973
37EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.48946269
38YY1_22570637_ChIP-Seq_MALME-3M_Human1.47915550
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.47077539
40CTCF_26484167_Chip-Seq_Bcells_Mouse1.47013623
41CTCF_27219007_Chip-Seq_ERYTHROID_Human1.46547595
42ELK3_25401928_ChIP-Seq_HUVEC_Human1.46377574
43CTCF_18555785_ChIP-Seq_MESCs_Mouse1.45961426
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42492451
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41983784
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41920573
47E2F1_20622854_ChIP-Seq_HELA_Human1.41880177
48EZH2_22144423_ChIP-Seq_EOC_Human1.41635931
49ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.41420589
50SA1_27219007_Chip-Seq_Bcells_Human1.40830879
51MAF_26560356_Chip-Seq_TH2_Human1.39752441
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.39696826
53PHF8_20622854_ChIP-Seq_HELA_Human1.38879513
54SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.38831521
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.37805371
56CTCF_20526341_ChIP-Seq_ESCs_Human1.37075454
57VDR_24763502_ChIP-Seq_THP-1_Human1.36880770
58MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.35016463
59GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.34913969
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.34799494
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.33255461
62MYC_22102868_ChIP-Seq_BL_Human1.32626216
63SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.32357586
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32127834
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.31305242
66NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30907361
67CTCF_27219007_Chip-Seq_Bcells_Human1.30394165
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30318082
69RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.29478917
70SMC4_20622854_ChIP-Seq_HELA_Human1.28591152
71CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26958319
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25293308
73XRN2_22483619_ChIP-Seq_HELA_Human1.23476533
74FOXP1_21924763_ChIP-Seq_HESCs_Human1.22905253
75CTCF_21964334_Chip-Seq_Bcells_Human1.22474903
76PU.1_20513432_ChIP-Seq_Bcells_Mouse1.22372852
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.21410632
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21215616
79SPI1_20517297_ChIP-Seq_HL60_Human1.20511173
80CTCF_21964334_ChIP-Seq_BJAB-B_Human1.19835296
81KDM2B_26808549_Chip-Seq_DND41_Human1.19735033
82RUNX1_22412390_ChIP-Seq_EML_Mouse1.19033748
83GABP_19822575_ChIP-Seq_HepG2_Human1.18808060
84GATA1_19941827_ChIP-Seq_MEL_Mouse1.18588606
85* P300_27268052_Chip-Seq_Bcells_Human1.18027113
86MAF_26560356_Chip-Seq_TH1_Human1.16317230
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13896929
88IRF8_22096565_ChIP-ChIP_GC-B_Human1.10845103
89* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09736704
90RARB_24833708_ChIP-Seq_LIVER_Mouse1.06273901
91RACK7_27058665_Chip-Seq_MCF-7_Human1.06182692
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06181861
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05958520
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05125441
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03683296
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03243157
97SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03082224
98* NCOR1_26117541_ChIP-Seq_K562_Human1.02778795
99SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02356514
100BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.02183719

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology3.85111864
2MP0004859_abnormal_synaptic_plasticity3.30843460
3MP0005058_abnormal_lysosome_morphology2.39783383
4MP0001968_abnormal_touch/_nociception2.34963089
5MP0001905_abnormal_dopamine_level2.26669140
6MP0003880_abnormal_central_pattern2.13584514
7MP0002736_abnormal_nociception_after2.07132935
8MP0009278_abnormal_bone_marrow2.06618945
9MP0005671_abnormal_response_to2.03429813
10MP0006036_abnormal_mitochondrial_physio2.03228201
11MP0003303_peritoneal_inflammation1.96724011
12MP0003436_decreased_susceptibility_to1.96114197
13MP0002148_abnormal_hypersensitivity_rea1.90277595
14MP0002653_abnormal_ependyma_morphology1.85824453
15MP0000465_gastrointestinal_hemorrhage1.81929711
16MP0005397_hematopoietic_system_phenotyp1.76389810
17MP0001545_abnormal_hematopoietic_system1.76389810
18MP0005000_abnormal_immune_tolerance1.73335278
19MP0003806_abnormal_nucleotide_metabolis1.70933980
20MP0005646_abnormal_pituitary_gland1.70670655
21MP0003635_abnormal_synaptic_transmissio1.68902534
22MP0005083_abnormal_biliary_tract1.67503526
23MP0008260_abnormal_autophagy1.67227425
24MP0003075_altered_response_to1.67050990
25MP0003186_abnormal_redox_activity1.62400640
26MP0002733_abnormal_thermal_nociception1.61018186
27MP0004147_increased_porphyrin_level1.59351775
28MP0003879_abnormal_hair_cell1.59063373
29MP0008004_abnormal_stomach_pH1.57731654
30MP0003787_abnormal_imprinting1.57468189
31MP0009379_abnormal_foot_pigmentation1.56212138
32MP0003866_abnormal_defecation1.54071377
33MP0006276_abnormal_autonomic_nervous1.53925517
34MP0001970_abnormal_pain_threshold1.53775069
35MP0001835_abnormal_antigen_presentation1.53638377
36MP0005025_abnormal_response_to1.51847336
37MP0002064_seizures1.51351933
38MP0009333_abnormal_splenocyte_physiolog1.49057007
39MP0003724_increased_susceptibility_to1.48620399
40MP0009745_abnormal_behavioral_response1.38666368
41MP0005423_abnormal_somatic_nervous1.38497290
42MP0000343_altered_response_to1.37756711
43MP0002723_abnormal_immune_serum1.35136059
44MP0002420_abnormal_adaptive_immunity1.32780113
45MP0002063_abnormal_learning/memory/cond1.32141991
46MP0001819_abnormal_immune_cell1.30435350
47MP0005645_abnormal_hypothalamus_physiol1.30231890
48MP0004510_myositis1.27568615
49MP0009840_abnormal_foam_cell1.27435659
50MP0002822_catalepsy1.26938121
51MP0006035_abnormal_mitochondrial_morpho1.26632883
52MP0008874_decreased_physiological_sensi1.26594191
53MP0002398_abnormal_bone_marrow1.25865054
54MP0002132_abnormal_respiratory_system1.25512856
55MP0002735_abnormal_chemical_nociception1.24751302
56MP0005451_abnormal_body_composition1.24534570
57MP0003329_amyloid_beta_deposits1.23386808
58MP0005535_abnormal_body_temperature1.19774557
59MP0002572_abnormal_emotion/affect_behav1.19452484
60MP0002272_abnormal_nervous_system1.17909786
61MP0009046_muscle_twitch1.17382599
62MP0005387_immune_system_phenotype1.16073968
63MP0001790_abnormal_immune_system1.16073968
64MP0002419_abnormal_innate_immunity1.13088442
65MP0005084_abnormal_gallbladder_morpholo1.12422618
66MP0001800_abnormal_humoral_immune1.08254948
67MP0000716_abnormal_immune_system1.08006118
68MP0002452_abnormal_antigen_presenting1.07880708
69MP0002429_abnormal_blood_cell1.04080244
70MP0002734_abnormal_mechanical_nocicepti1.03818901
71MP0001986_abnormal_taste_sensitivity1.02961132
72MP0009764_decreased_sensitivity_to1.02545784
73MP0000685_abnormal_immune_system1.01973076
74MP0002722_abnormal_immune_system1.00566656
75MP0009785_altered_susceptibility_to1.00141013
76MP0000604_amyloidosis0.99423795
77MP0001764_abnormal_homeostasis0.99196369
78MP0005410_abnormal_fertilization0.98979268
79MP0000689_abnormal_spleen_morphology0.97593575
80MP0000681_abnormal_thyroid_gland0.97102423
81MP0005075_abnormal_melanosome_morpholog0.96582730
82MP0003763_abnormal_thymus_physiology0.95508897
83MP0005670_abnormal_white_adipose0.94229541
84MP0001663_abnormal_digestive_system0.93245751
85MP0008872_abnormal_physiological_respon0.92258855
86MP0006082_CNS_inflammation0.92247342
87MP0001533_abnormal_skeleton_physiology0.91441925
88MP0003638_abnormal_response/metabolism_0.88016832
89MP0001845_abnormal_inflammatory_respons0.87519745
90MP0010155_abnormal_intestine_physiology0.87485636
91MP0003172_abnormal_lysosome_physiology0.87249171
92MP0004270_analgesia0.87246561
93MP0002557_abnormal_social/conspecific_i0.85751629
94MP0001664_abnormal_digestion0.81411413
95MP0009765_abnormal_xenobiotic_induced0.81231136
96MP0008569_lethality_at_weaning0.80944098
97MP0005166_decreased_susceptibility_to0.80809411
98MP0005584_abnormal_enzyme/coenzyme_acti0.79377863
99MP0000372_irregular_coat_pigmentation0.79258214
100MP0004811_abnormal_neuron_physiology0.77562786

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)5.02621657
2Prolonged bleeding time (HP:0003010)4.30113563
3Purpura (HP:0000979)4.07627756
4Myokymia (HP:0002411)4.06720386
5Abnormal mitochondria in muscle tissue (HP:0008316)3.90171776
6Hepatocellular necrosis (HP:0001404)3.89274010
7Mitochondrial inheritance (HP:0001427)3.77431535
8Abnormality of the heme biosynthetic pathway (HP:0010472)3.73934098
9Acute necrotizing encephalopathy (HP:0006965)3.72901881
10Decreased activity of mitochondrial respiratory chain (HP:0008972)3.70013548
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.70013548
12Hepatic necrosis (HP:0002605)3.65523448
13Increased intramyocellular lipid droplets (HP:0012240)3.58517243
14Increased muscle lipid content (HP:0009058)3.55304558
15Hyperthyroidism (HP:0000836)3.29751269
16Acute encephalopathy (HP:0006846)3.29042986
17Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.25898524
18Increased CSF lactate (HP:0002490)3.20052408
19Visual hallucinations (HP:0002367)3.11728408
20Chronic obstructive pulmonary disease (HP:0006510)3.01224823
21Obstructive lung disease (HP:0006536)3.01224823
22Progressive macrocephaly (HP:0004481)2.98238767
23Epistaxis (HP:0000421)2.85542819
24Renal Fanconi syndrome (HP:0001994)2.85152264
25Polyphagia (HP:0002591)2.77572267
263-Methylglutaconic aciduria (HP:0003535)2.66733403
27Elevated erythrocyte sedimentation rate (HP:0003565)2.65223283
28Menorrhagia (HP:0000132)2.54364863
29Increased IgM level (HP:0003496)2.49730938
30Abnormality of glycolipid metabolism (HP:0010969)2.46968124
31Abnormality of liposaccharide metabolism (HP:0010968)2.46968124
32Abnormality of glycosphingolipid metabolism (HP:0004343)2.46968124
33Truncus arteriosus (HP:0001660)2.45394736
34Dysostosis multiplex (HP:0000943)2.42176949
35Lactic acidosis (HP:0003128)2.41216138
36Abnormality of macrophages (HP:0004311)2.40226711
37Cerebral palsy (HP:0100021)2.37780599
38Emotional lability (HP:0000712)2.36427827
39Agammaglobulinemia (HP:0004432)2.36067698
40Abnormal platelet volume (HP:0011876)2.32418117
41Delusions (HP:0000746)2.32332296
42Hepatosplenomegaly (HP:0001433)2.31285576
43Hypertensive crisis (HP:0100735)2.31137614
44Cerebral edema (HP:0002181)2.29834722
45Failure to thrive in infancy (HP:0001531)2.24755109
46Increased mean platelet volume (HP:0011877)2.20743508
47Supranuclear gaze palsy (HP:0000605)2.20341548
48Abnormality of cells of the erythroid lineage (HP:0012130)2.16146353
49Stomatitis (HP:0010280)2.14862225
50Respiratory failure (HP:0002878)2.14600897
51Focal dystonia (HP:0004373)2.14555909
52Increased serum ferritin (HP:0003281)2.13576365
53Abnormal platelet function (HP:0011869)2.13124905
54Impaired platelet aggregation (HP:0003540)2.13124905
55Mutism (HP:0002300)2.11330067
56Ankle clonus (HP:0011448)2.09744571
57Lipid accumulation in hepatocytes (HP:0006561)2.09431646
58Craniofacial dystonia (HP:0012179)2.09202779
59Exertional dyspnea (HP:0002875)2.09060645
60Cerebral hypomyelination (HP:0006808)2.08965817
61Increased hepatocellular lipid droplets (HP:0006565)2.08342500
62Progressive microcephaly (HP:0000253)2.08206392
63Abnormality of lateral ventricle (HP:0030047)2.07803374
64Abnormal number of erythroid precursors (HP:0012131)2.07601837
65Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.07381500
66Increased neuronal autofluorescent lipopigment (HP:0002074)2.07159864
67Microretrognathia (HP:0000308)2.07093357
68Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.06382729
69Increased cerebral lipofuscin (HP:0011813)2.06247383
70Neuronal loss in central nervous system (HP:0002529)2.06066018
71Increased serum lactate (HP:0002151)2.06021728
72Increased IgE level (HP:0003212)2.03340342
73Exercise intolerance (HP:0003546)2.02225576
74Absent rod-and cone-mediated responses on ERG (HP:0007688)2.00414291
75Generalized aminoaciduria (HP:0002909)2.00152730
76Abnormal hemoglobin (HP:0011902)1.98504063
77Abnormality of fatty-acid metabolism (HP:0004359)1.95745812
78Dicarboxylic aciduria (HP:0003215)1.95661572
79Abnormality of dicarboxylic acid metabolism (HP:0010995)1.95661572
80Abnormal gallbladder physiology (HP:0012438)1.95120828
81Cholecystitis (HP:0001082)1.95120828
82Vacuolated lymphocytes (HP:0001922)1.94688998
83Prolonged neonatal jaundice (HP:0006579)1.92311703
84Abnormal eating behavior (HP:0100738)1.90129623
85Abnormality of iron homeostasis (HP:0011031)1.87875141
86Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.84349639
87Hypergammaglobulinemia (HP:0010702)1.81653388
88Diplopia (HP:0000651)1.80402602
89Abnormality of binocular vision (HP:0011514)1.80402602
90Gliosis (HP:0002171)1.78984147
91Mediastinal lymphadenopathy (HP:0100721)1.78714661
92Focal motor seizures (HP:0011153)1.78109296
93Encephalitis (HP:0002383)1.77826782
94Respiratory difficulties (HP:0002880)1.76353596
95CNS demyelination (HP:0007305)1.75767003
96Muscle fiber atrophy (HP:0100295)1.74827632
97Ragged-red muscle fibers (HP:0003200)1.73598195
98J-shaped sella turcica (HP:0002680)1.72875374
99Growth hormone excess (HP:0000845)1.72856913
100Gingival bleeding (HP:0000225)1.70926466

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK24.33149434
2MAP3K113.65990261
3PIM23.56634956
4TESK13.10130743
5NME23.04105828
6ARAF2.91151820
7BCKDK2.86926564
8RIPK42.43999646
9KDR2.27744334
10TAOK22.03846140
11VRK22.02484591
12ERN12.02357102
13MAP4K11.81915586
14LIMK11.78440637
15DAPK11.76693530
16CDK191.68892993
17GRK61.61844183
18DAPK21.56799745
19GRK51.55184049
20TNK21.46226768
21ABL21.44224370
22BRAF1.35638409
23EPHA41.33915543
24TAOK31.27600950
25IRAK31.27505446
26FES1.27492961
27MAP2K71.24623076
28MAP4K21.16826066
29MAPKAPK31.15345285
30DAPK31.14575368
31TBK11.12292464
32TAOK11.11018154
33PAK61.10928061
34DYRK21.07414771
35SYK1.07167803
36SCYL21.05887876
37BMX1.05014334
38PRKD31.04975303
39BTK1.01494907
40ILK0.93268390
41STK160.89761473
42MINK10.88397690
43CAMKK10.87358095
44IKBKB0.86929117
45PAK10.83982031
46RAF10.83195058
47CSNK1G30.80734486
48MAP2K60.80601545
49MAP2K30.79130519
50TLK10.77778355
51MAPK130.75257538
52AURKA0.74244164
53TXK0.72751258
54PKN10.71110043
55CAMK2G0.68970449
56MAP3K50.68955751
57MAPK120.64037752
58LRRK20.63922574
59ZAP700.62712080
60PRKD20.62516538
61CDK140.62003707
62PRPF4B0.60338499
63PRKCQ0.59595042
64MAP3K10.59291591
65CSF1R0.58641787
66CSNK1G20.58493771
67BMPR20.57919835
68SIK10.56992694
69RPS6KA50.56704932
70MARK20.56355256
71MAP2K20.56315424
72CAMK10.54640305
73IRAK20.54175503
74PDK10.53138222
75ADRBK20.51743970
76DYRK1B0.51678823
77PRKCI0.51092936
78IRAK40.51039124
79MATK0.50433634
80PDPK10.50096672
81SIK20.49283111
82LYN0.47530023
83TEC0.46253649
84LCK0.45756771
85CDK11A0.45390513
86MAP3K120.45078449
87MAPK40.45019620
88IKBKE0.44763892
89PIM10.44473842
90NTRK30.43896242
91PINK10.41944302
92ITK0.41415218
93HCK0.41163375
94KIT0.40912874
95PRKCD0.39930989
96SIK30.39827045
97CDK150.39368933
98CSNK1A1L0.38330857
99PRKD10.38066524
100PRKCG0.37985398

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.21530658
2Parkinsons disease_Homo sapiens_hsa050123.73021770
3Synaptic vesicle cycle_Homo sapiens_hsa047213.30272051
4Sulfur relay system_Homo sapiens_hsa041223.19706651
5Ribosome_Homo sapiens_hsa030103.12145865
6SNARE interactions in vesicular transport_Homo sapiens_hsa041302.79560084
7Collecting duct acid secretion_Homo sapiens_hsa049662.48632103
8Alzheimers disease_Homo sapiens_hsa050102.40785173
9Primary immunodeficiency_Homo sapiens_hsa053402.29481099
10Huntingtons disease_Homo sapiens_hsa050162.22760256
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.19163175
12Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050142.18020562
13Proteasome_Homo sapiens_hsa030501.86804806
14Fatty acid elongation_Homo sapiens_hsa000621.70093343
15RNA polymerase_Homo sapiens_hsa030201.60758222
16Cardiac muscle contraction_Homo sapiens_hsa042601.59904498
17Base excision repair_Homo sapiens_hsa034101.53783170
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.53027763
19Vibrio cholerae infection_Homo sapiens_hsa051101.47449695
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44081831
21Sulfur metabolism_Homo sapiens_hsa009201.27710546
22Pyrimidine metabolism_Homo sapiens_hsa002401.27609843
23Shigellosis_Homo sapiens_hsa051311.26214777
24Rheumatoid arthritis_Homo sapiens_hsa053231.25771052
25Regulation of autophagy_Homo sapiens_hsa041401.24445160
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.21517106
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.16863679
28Lysosome_Homo sapiens_hsa041421.14077500
29Allograft rejection_Homo sapiens_hsa053301.13555662
30Glutathione metabolism_Homo sapiens_hsa004801.10575246
31Morphine addiction_Homo sapiens_hsa050321.09649027
32Platelet activation_Homo sapiens_hsa046111.04546288
33GABAergic synapse_Homo sapiens_hsa047271.04266992
34Graft-versus-host disease_Homo sapiens_hsa053321.02293779
35Type I diabetes mellitus_Homo sapiens_hsa049401.00439747
36Nicotine addiction_Homo sapiens_hsa050330.96916837
37Autoimmune thyroid disease_Homo sapiens_hsa053200.96890131
38Arachidonic acid metabolism_Homo sapiens_hsa005900.96855349
39Salmonella infection_Homo sapiens_hsa051320.96646875
40Glycosaminoglycan degradation_Homo sapiens_hsa005310.93427622
41Asthma_Homo sapiens_hsa053100.93044358
42Hematopoietic cell lineage_Homo sapiens_hsa046400.92987802
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91158559
44Pentose phosphate pathway_Homo sapiens_hsa000300.89578599
45Phototransduction_Homo sapiens_hsa047440.89259878
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86887532
47Circadian entrainment_Homo sapiens_hsa047130.86672724
48Endocytosis_Homo sapiens_hsa041440.86149500
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85534043
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85026034
51Other glycan degradation_Homo sapiens_hsa005110.81779604
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79424333
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78375725
54Peroxisome_Homo sapiens_hsa041460.76654840
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76494202
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75988024
57Purine metabolism_Homo sapiens_hsa002300.74601230
58Phagosome_Homo sapiens_hsa041450.73471210
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71633121
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.71314762
61Amphetamine addiction_Homo sapiens_hsa050310.68814005
62Alcoholism_Homo sapiens_hsa050340.67127565
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66306410
64Folate biosynthesis_Homo sapiens_hsa007900.65378497
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65076914
66Olfactory transduction_Homo sapiens_hsa047400.62794861
67Tuberculosis_Homo sapiens_hsa051520.62360644
68Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61176499
69Acute myeloid leukemia_Homo sapiens_hsa052210.60923975
70Dopaminergic synapse_Homo sapiens_hsa047280.58495815
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57162082
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.55881210
73Metabolic pathways_Homo sapiens_hsa011000.54166691
74VEGF signaling pathway_Homo sapiens_hsa043700.53584608
75Leishmaniasis_Homo sapiens_hsa051400.52799960
76Osteoclast differentiation_Homo sapiens_hsa043800.52568485
77Fructose and mannose metabolism_Homo sapiens_hsa000510.51895423
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51836252
79Prion diseases_Homo sapiens_hsa050200.50860192
80Cocaine addiction_Homo sapiens_hsa050300.48788306
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48192844
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47882625
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47476428
84Antigen processing and presentation_Homo sapiens_hsa046120.46042113
85Vitamin B6 metabolism_Homo sapiens_hsa007500.43502843
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43215671
87Chemokine signaling pathway_Homo sapiens_hsa040620.43137157
88Galactose metabolism_Homo sapiens_hsa000520.42566501
89Systemic lupus erythematosus_Homo sapiens_hsa053220.41802185
90Long-term potentiation_Homo sapiens_hsa047200.39257298
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39070162
92Malaria_Homo sapiens_hsa051440.38936506
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37117001
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36902107
95T cell receptor signaling pathway_Homo sapiens_hsa046600.36030666
96DNA replication_Homo sapiens_hsa030300.35114686
97Pertussis_Homo sapiens_hsa051330.33461346
98B cell receptor signaling pathway_Homo sapiens_hsa046620.33411228
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33165548
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32675983

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