C8ORF82

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1GDP-mannose metabolic process (GO:0019673)5.99743779
2proline biosynthetic process (GO:0006561)4.86759129
3ribosomal small subunit biogenesis (GO:0042274)4.56789261
4protein carboxylation (GO:0018214)4.21046856
5peptidyl-glutamic acid carboxylation (GO:0017187)4.21046856
6urea cycle (GO:0000050)4.13762352
7mannose metabolic process (GO:0006013)4.00414169
8protein retention in ER lumen (GO:0006621)3.92950949
9urea metabolic process (GO:0019627)3.88516021
10UV protection (GO:0009650)3.83833209
11proline metabolic process (GO:0006560)3.83177439
12negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.75156498
13regulation of fatty acid beta-oxidation (GO:0031998)3.72003780
14negative regulation of cell size (GO:0045792)3.63118541
15sulfur amino acid catabolic process (GO:0000098)3.60330965
16NADH metabolic process (GO:0006734)3.57298160
17adenosine receptor signaling pathway (GO:0001973)3.56898007
18endothelial cell chemotaxis (GO:0035767)3.54370144
19regulation of cholesterol biosynthetic process (GO:0045540)3.53692704
20negative regulation of erythrocyte differentiation (GO:0045647)3.45365545
21planar cell polarity pathway involved in neural tube closure (GO:0090179)3.44645014
22regulation of mammary gland epithelial cell proliferation (GO:0033599)3.43293209
23maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.38138698
24semaphorin-plexin signaling pathway (GO:0071526)3.37372530
25nitrogen cycle metabolic process (GO:0071941)3.36053243
26protein insertion into membrane (GO:0051205)3.33881811
27cell-cell junction maintenance (GO:0045217)3.33820847
28positive regulation of fatty acid beta-oxidation (GO:0032000)3.31358172
29apoptotic process involved in morphogenesis (GO:0060561)3.25588419
30regulation of early endosome to late endosome transport (GO:2000641)3.15839359
31regulation of cholesterol metabolic process (GO:0090181)3.12708457
32regulation of glucose import in response to insulin stimulus (GO:2001273)3.11655158
33glutamine family amino acid biosynthetic process (GO:0009084)3.09620191
34negative regulation of fatty acid transport (GO:2000192)3.02136241
35epithelial cell-cell adhesion (GO:0090136)3.01580276
36protein localization to endosome (GO:0036010)3.00170623
37desmosome organization (GO:0002934)2.97786467
38regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.93562685
39regulation of fatty acid oxidation (GO:0046320)2.92974455
40regulation of apoptotic process involved in morphogenesis (GO:1902337)2.92381896
41L-phenylalanine metabolic process (GO:0006558)2.92177639
42erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.92177639
43maternal placenta development (GO:0001893)2.90688911
44regulation of cholesterol homeostasis (GO:2000188)2.90545825
45viral transcription (GO:0019083)2.89386108
46activation of Rac GTPase activity (GO:0032863)2.87544604
47adenine nucleotide transport (GO:0051503)2.85579877
48positive regulation of histone deacetylation (GO:0031065)2.84594624
49folic acid metabolic process (GO:0046655)2.82823383
50atrioventricular valve morphogenesis (GO:0003181)2.82350903
51glycosphingolipid catabolic process (GO:0046479)2.80629261
52positive regulation of Cdc42 GTPase activity (GO:0043089)2.79505455
53glutathione biosynthetic process (GO:0006750)2.79401477
54adherens junction assembly (GO:0034333)2.75786384
55positive regulation of triglyceride metabolic process (GO:0090208)2.74590549
56focal adhesion assembly (GO:0048041)2.72643265
57cell-substrate adherens junction assembly (GO:0007045)2.72643265
58positive regulation of triglyceride lipase activity (GO:0061365)2.67512743
59positive regulation of lipoprotein lipase activity (GO:0051006)2.67512743
60regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.65651443
61purine ribonucleotide transport (GO:0015868)2.64729042
62purine nucleotide transport (GO:0015865)2.61062307
63positive regulation of triglyceride biosynthetic process (GO:0010867)2.60936229
64response to food (GO:0032094)2.60273787
65oligosaccharide catabolic process (GO:0009313)2.58983087
66negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.57738028
67endocytic recycling (GO:0032456)2.57275183
68modulation by virus of host process (GO:0019054)2.56756945
69regulation of hydrogen peroxide metabolic process (GO:0010310)2.55913345
70basement membrane organization (GO:0071711)2.54816768
71positive regulation of lipid catabolic process (GO:0050996)2.52489734
72positive regulation of fatty acid oxidation (GO:0046321)2.52434250
73low-density lipoprotein particle clearance (GO:0034383)2.50739465
74fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.50697775
75glucose catabolic process (GO:0006007)2.50506883
76COPI coating of Golgi vesicle (GO:0048205)2.50033387
77Golgi transport vesicle coating (GO:0048200)2.50033387
78translational termination (GO:0006415)2.49724646
79branching involved in mammary gland duct morphogenesis (GO:0060444)2.47762806
80mammary gland epithelial cell differentiation (GO:0060644)2.47061615
81glycolipid catabolic process (GO:0019377)2.46266722
82cell junction maintenance (GO:0034331)2.44264281
83tooth mineralization (GO:0034505)2.43824029
84nonribosomal peptide biosynthetic process (GO:0019184)2.43471091
85negative regulation of viral release from host cell (GO:1902187)2.43411576
86regulation of translational fidelity (GO:0006450)2.42774995
87glucose 6-phosphate metabolic process (GO:0051156)2.42208859
88regulation of extracellular matrix disassembly (GO:0010715)2.41909342
89negative regulation of catenin import into nucleus (GO:0035414)2.41629276
90modulation by symbiont of host cellular process (GO:0044068)2.41409966
91retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.40754555
92diaphragm development (GO:0060539)2.39755746
93response to misfolded protein (GO:0051788)2.39348054
94positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.38150831
95establishment of apical/basal cell polarity (GO:0035089)2.37953400
96translational elongation (GO:0006414)2.37468838
97regulation of fatty acid biosynthetic process (GO:0042304)2.36824945
98oxaloacetate metabolic process (GO:0006107)2.34840473
99regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.34814790
100actin filament bundle organization (GO:0061572)2.33982015

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.26216297
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.08930861
3LXR_22292898_ChIP-Seq_THP-1_Human3.06995531
4TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.66783851
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.61590206
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.57824844
7RACK7_27058665_Chip-Seq_MCF-7_Human2.56299473
8ZNF263_19887448_ChIP-Seq_K562_Human2.26705227
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.25048799
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.18813884
11ELK3_25401928_ChIP-Seq_HUVEC_Human2.18494385
12ERG_21242973_ChIP-ChIP_JURKAT_Human2.16533054
13MYC_22102868_ChIP-Seq_BL_Human2.14188966
14P68_20966046_ChIP-Seq_HELA_Human2.11697589
15TET1_21451524_ChIP-Seq_MESCs_Mouse2.09296499
16KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.03717610
17KDM2B_26808549_Chip-Seq_SUP-B15_Human2.03249935
18* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.00113556
19STAT6_21828071_ChIP-Seq_BEAS2B_Human1.86912094
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85777506
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.81011517
22KDM2B_26808549_Chip-Seq_DND41_Human1.77331643
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.75903831
24XRN2_22483619_ChIP-Seq_HELA_Human1.72731375
25SRY_22984422_ChIP-ChIP_TESTIS_Rat1.72119115
26SA1_27219007_Chip-Seq_ERYTHROID_Human1.65721733
27CTCF_27219007_Chip-Seq_ERYTHROID_Human1.64821463
28ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.60294234
29TCF7_22412390_ChIP-Seq_EML_Mouse1.59700208
30SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.59075335
31CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.58912645
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.58551595
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.58385651
34SMC4_20622854_ChIP-Seq_HELA_Human1.55556448
35CTCF_27219007_Chip-Seq_Bcells_Human1.54359503
36KDM2B_26808549_Chip-Seq_K562_Human1.54053520
37BCOR_27268052_Chip-Seq_Bcells_Human1.53630621
38CREB1_26743006_Chip-Seq_LNCaP_Human1.52698275
39SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.52379823
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.52219298
41UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.51627781
42VDR_24763502_ChIP-Seq_THP-1_Human1.48621696
43EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.47902127
44CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.47703118
45BCL6_27268052_Chip-Seq_Bcells_Human1.47087513
46PPARA_22158963_ChIP-Seq_LIVER_Mouse1.46435324
47CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43730120
48MAF_26560356_Chip-Seq_TH2_Human1.42836395
49CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.41836744
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41792945
51RXR_22158963_ChIP-Seq_LIVER_Mouse1.40611751
52SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.40458019
53ELF1_20517297_ChIP-Seq_JURKAT_Human1.39028474
54KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38988210
55MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.37276372
56ATF3_27146783_Chip-Seq_COLON_Human1.35109393
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.33803567
58TP53_22127205_ChIP-Seq_IMR90_Human1.31010707
59RARB_24833708_ChIP-Seq_LIVER_Mouse1.30930142
60E2F1_20622854_ChIP-Seq_HELA_Human1.30825548
61PHF8_20622854_ChIP-Seq_HELA_Human1.29226179
62FOXP1_21924763_ChIP-Seq_HESCs_Human1.28476360
63RARA_24833708_ChIP-Seq_LIVER_Mouse1.27876517
64SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.26184683
65ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26108674
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24289660
67CTCF_21964334_Chip-Seq_Bcells_Human1.21518737
68MYC_18358816_ChIP-ChIP_MESCs_Mouse1.20389476
69TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19825731
70CTCF_26484167_Chip-Seq_Bcells_Mouse1.18884133
71KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17928411
72RUNX1_27514584_Chip-Seq_MCF-7_Human1.16761532
73KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14418768
74KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14291852
75MAF_26560356_Chip-Seq_TH1_Human1.14078722
76KDM2B_26808549_Chip-Seq_JURKAT_Human1.13309330
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12462979
78NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12161894
79NCOR1_26117541_ChIP-Seq_K562_Human1.10853113
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10547356
81RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10255804
82PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09241425
83CTCF_21964334_ChIP-Seq_BJAB-B_Human1.08801473
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07611614
85ETS1_21867929_ChIP-Seq_TH2_Mouse1.07276993
86CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06840203
87JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.06835134
88SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05751302
89SA1_27219007_Chip-Seq_Bcells_Human1.05032961
90YY1_22570637_ChIP-Seq_MALME-3M_Human1.04254819
91GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03935149
92CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03225847
93RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03081202
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02685593
95ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02641299
96E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02566246
97THAP11_20581084_ChIP-Seq_MESCs_Mouse1.02510400
98JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.02178216
99TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01623529
100P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01572352

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.66556325
2MP0005058_abnormal_lysosome_morphology3.63863818
3MP0009840_abnormal_foam_cell3.22811634
4MP0005451_abnormal_body_composition2.94862208
5MP0005409_darkened_coat_color2.82830605
6MP0010234_abnormal_vibrissa_follicle2.69720404
7MP0005076_abnormal_cell_differentiation2.66291615
8MP0004185_abnormal_adipocyte_glucose2.64914949
9MP0005360_urolithiasis2.49253343
10MP0002139_abnormal_hepatobiliary_system2.47114094
11MP0003453_abnormal_keratinocyte_physiol2.40873671
12MP0000751_myopathy2.23197781
13MP0009379_abnormal_foot_pigmentation2.20585620
14MP0005501_abnormal_skin_physiology2.16292377
15MP0000678_abnormal_parathyroid_gland2.13675712
16MP0002249_abnormal_larynx_morphology2.10893631
17MP0005171_absent_coat_pigmentation2.10315161
18MP0004858_abnormal_nervous_system2.03383378
19MP0005083_abnormal_biliary_tract2.01407475
20MP0005666_abnormal_adipose_tissue1.97828928
21MP0003123_paternal_imprinting1.93696799
22MP0005670_abnormal_white_adipose1.91639140
23MP0000003_abnormal_adipose_tissue1.82736231
24MP0002796_impaired_skin_barrier1.81867233
25MP0003172_abnormal_lysosome_physiology1.73923624
26MP0005174_abnormal_tail_pigmentation1.73870637
27MP0005375_adipose_tissue_phenotype1.73468150
28MP0005257_abnormal_intraocular_pressure1.72965615
29MP0005365_abnormal_bile_salt1.71368320
30MP0001849_ear_inflammation1.70808280
31MP0001661_extended_life_span1.65110897
32MP0000747_muscle_weakness1.53045144
33MP0001986_abnormal_taste_sensitivity1.47843028
34MP0000750_abnormal_muscle_regeneration1.47738517
35MP0005330_cardiomyopathy1.46518905
36MP0004130_abnormal_muscle_cell1.40639895
37MP0000015_abnormal_ear_pigmentation1.40248575
38MP0000538_abnormal_urinary_bladder1.35495186
39MP0003806_abnormal_nucleotide_metabolis1.32956380
40MP0000013_abnormal_adipose_tissue1.30497688
41MP0005332_abnormal_amino_acid1.29096689
42MP0001756_abnormal_urination1.29065927
43MP0005423_abnormal_somatic_nervous1.27375676
44MP0002089_abnormal_postnatal_growth/wei1.23636822
45MP0010030_abnormal_orbit_morphology1.22326245
46MP0009384_cardiac_valve_regurgitation1.22211802
47MP0008875_abnormal_xenobiotic_pharmacok1.21590827
48MP0003879_abnormal_hair_cell1.21537569
49MP0004510_myositis1.11507504
50MP0001188_hyperpigmentation1.11340052
51MP0004381_abnormal_hair_follicle1.10142730
52MP0003279_aneurysm1.09241886
53MP0001664_abnormal_digestion1.08624762
54MP0004019_abnormal_vitamin_homeostasis1.05776332
55MP0001873_stomach_inflammation1.05210495
56MP0003191_abnormal_cellular_cholesterol1.04552460
57MP0000537_abnormal_urethra_morphology1.03984897
58MP0002060_abnormal_skin_morphology0.99258116
59MP0009931_abnormal_skin_appearance0.98754163
60MP0009643_abnormal_urine_homeostasis0.95844077
61MP0002098_abnormal_vibrissa_morphology0.95544216
62MP0002118_abnormal_lipid_homeostasis0.95253709
63MP0000462_abnormal_digestive_system0.94473213
64MP0004233_abnormal_muscle_weight0.92441657
65MP0000470_abnormal_stomach_morphology0.88689549
66MP0001348_abnormal_lacrimal_gland0.87292564
67MP0002877_abnormal_melanocyte_morpholog0.86306991
68MP0009053_abnormal_anal_canal0.83252808
69MP0003136_yellow_coat_color0.83126670
70MP0001502_abnormal_circadian_rhythm0.82914138
71MP0001216_abnormal_epidermal_layer0.82662708
72MP0008438_abnormal_cutaneous_collagen0.82326808
73MP0009278_abnormal_bone_marrow0.81474804
74MP0002970_abnormal_white_adipose0.81368033
75MP0000566_synostosis0.81341479
76MP0000759_abnormal_skeletal_muscle0.80608288
77MP0010329_abnormal_lipoprotein_level0.80570491
78MP0003566_abnormal_cell_adhesion0.80126397
79MP0000609_abnormal_liver_physiology0.79802677
80MP0010771_integument_phenotype0.79559723
81MP0004087_abnormal_muscle_fiber0.77981193
82MP0000467_abnormal_esophagus_morphology0.77081309
83MP0008260_abnormal_autophagy0.76575448
84MP0005584_abnormal_enzyme/coenzyme_acti0.76292333
85MP0003942_abnormal_urinary_system0.75293660
86MP0000377_abnormal_hair_follicle0.74698113
87MP0003091_abnormal_cell_migration0.74603306
88MP0002254_reproductive_system_inflammat0.74251887
89MP0002971_abnormal_brown_adipose0.73198566
90MP0000858_altered_metastatic_potential0.73055654
91MP0003303_peritoneal_inflammation0.71536412
92MP0001765_abnormal_ion_homeostasis0.70980730
93MP0001958_emphysema0.68931340
94MP0000733_abnormal_muscle_development0.67929778
95MP0003329_amyloid_beta_deposits0.67850684
96MP0001944_abnormal_pancreas_morphology0.66987082
97MP0000477_abnormal_intestine_morphology0.66301294
98MP0000681_abnormal_thyroid_gland0.65054077
99MP0000534_abnormal_ureter_morphology0.64685356
100MP0000367_abnormal_coat/_hair0.64219858

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)4.46997704
2Thin bony cortex (HP:0002753)4.24926654
3Ulnar bowing (HP:0003031)4.15762639
4Hemorrhage of the eye (HP:0011885)3.42760353
5Turricephaly (HP:0000262)3.35418717
6Vaginal fistula (HP:0004320)2.92862008
7Myopathic facies (HP:0002058)2.85665381
8Hyperacusis (HP:0010780)2.61214539
9Distal lower limb muscle weakness (HP:0009053)2.59329580
10Rib fusion (HP:0000902)2.58927555
11Abnormality of mucopolysaccharide metabolism (HP:0011020)2.53893081
12Abnormality of polysaccharide metabolism (HP:0011012)2.53893081
13Abnormality of glycosaminoglycan metabolism (HP:0004371)2.53893081
14Bowed forearm bones (HP:0003956)2.53025792
15Bowing of the arm (HP:0006488)2.53025792
16Cervical subluxation (HP:0003308)2.52023219
17Achilles tendon contracture (HP:0001771)2.48374203
18Delayed epiphyseal ossification (HP:0002663)2.47469598
19Hyperparathyroidism (HP:0000843)2.45921047
20Urinary glycosaminoglycan excretion (HP:0003541)2.45618000
21Mucopolysacchariduria (HP:0008155)2.45618000
22Rectovaginal fistula (HP:0000143)2.45003488
23Rectal fistula (HP:0100590)2.45003488
24Intestinal fistula (HP:0100819)2.44313319
25Joint stiffness (HP:0001387)2.42565088
26Deep venous thrombosis (HP:0002625)2.38499569
27Coronal craniosynostosis (HP:0004440)2.38340710
28Prolonged partial thromboplastin time (HP:0003645)2.36543101
29Abnormality of the Achilles tendon (HP:0005109)2.36503562
30Annular pancreas (HP:0001734)2.36249944
31Stridor (HP:0010307)2.35147150
32Mesangial abnormality (HP:0001966)2.28030936
33Easy fatigability (HP:0003388)2.23313139
34Dysostosis multiplex (HP:0000943)2.19009880
35Poikiloderma (HP:0001029)2.18206732
36Ragged-red muscle fibers (HP:0003200)2.17608166
37Aplasia of the musculature (HP:0100854)2.17022222
38Abnormality of the intrinsic pathway (HP:0010989)2.16327833
39Bulbar palsy (HP:0001283)2.15622151
40Hyperthyroidism (HP:0000836)2.12363565
41Abnormality of monocarboxylic acid metabolism (HP:0010996)2.11695767
42Broad distal phalanx of finger (HP:0009836)2.10652545
43J-shaped sella turcica (HP:0002680)2.08900435
44Vertebral compression fractures (HP:0002953)2.07171394
45Asymmetric septal hypertrophy (HP:0001670)2.06256109
46Abnormality of the thoracic spine (HP:0100711)2.05805648
47Neonatal onset (HP:0003623)2.05443132
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.04184660
49Joint hemorrhage (HP:0005261)2.03507858
50Choanal stenosis (HP:0000452)2.02866924
51Thin ribs (HP:0000883)2.01790711
52Squamous cell carcinoma (HP:0002860)2.01366585
53Xanthomatosis (HP:0000991)2.00917798
54Distal lower limb amyotrophy (HP:0008944)2.00748928
55Progressive muscle weakness (HP:0003323)1.97069376
56Increased muscle lipid content (HP:0009058)1.96184293
57Congenital glaucoma (HP:0001087)1.93072305
58Abdominal distention (HP:0003270)1.92944488
59Broad face (HP:0000283)1.92475242
60Generalized amyotrophy (HP:0003700)1.91284087
61Abnormality of aromatic amino acid family metabolism (HP:0004338)1.90714461
62Protrusio acetabuli (HP:0003179)1.88952268
63Obstructive sleep apnea (HP:0002870)1.88795009
64Slender long bone (HP:0003100)1.87947756
65Asymmetry of the thorax (HP:0001555)1.87484762
66Disproportionate tall stature (HP:0001519)1.86693786
67Hypophosphatemia (HP:0002148)1.85280292
68Mildly elevated creatine phosphokinase (HP:0008180)1.83373463
69Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.83296860
70Flat acetabular roof (HP:0003180)1.82767039
71Upper limb amyotrophy (HP:0009129)1.81912930
72Distal upper limb amyotrophy (HP:0007149)1.81912930
73Lymphangioma (HP:0100764)1.81524552
74Anteriorly placed anus (HP:0001545)1.81433744
75Fragile skin (HP:0001030)1.79179784
76Abnormal urine phosphate concentration (HP:0012599)1.79076209
77Abnormality of cells of the erythroid lineage (HP:0012130)1.78839229
78Facial hemangioma (HP:0000329)1.78250681
79Increased connective tissue (HP:0009025)1.78025600
80Malnutrition (HP:0004395)1.76612465
81Short nail (HP:0001799)1.75758190
82Long palpebral fissure (HP:0000637)1.74465437
83Rectal prolapse (HP:0002035)1.74169787
84Abnormality of complement system (HP:0005339)1.73921057
85Atrioventricular block (HP:0001678)1.73770875
86Akinesia (HP:0002304)1.72556645
87Germ cell neoplasia (HP:0100728)1.70649814
88Thoracic kyphosis (HP:0002942)1.68927211
89Prolonged neonatal jaundice (HP:0006579)1.68452749
90Reticulocytosis (HP:0001923)1.68074142
91Abnormal number of erythroid precursors (HP:0012131)1.67747645
92Increased serum ferritin (HP:0003281)1.67660053
93Hypertriglyceridemia (HP:0002155)1.67531973
94Aplasia/Hypoplasia of the sacrum (HP:0008517)1.66872442
95Bone pain (HP:0002653)1.65205295
96Elevated alkaline phosphatase (HP:0003155)1.65019005
97Genu recurvatum (HP:0002816)1.64587314
98Systemic lupus erythematosus (HP:0002725)1.64448061
99Hypercortisolism (HP:0001578)1.64275978
100Cerebral aneurysm (HP:0004944)1.64259783

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.74278224
2SIK14.11909555
3NME23.25100442
4EPHA23.22176206
5IRAK33.14332094
6SMG13.08220572
7ERN12.90422176
8ICK2.78473080
9MAPK152.47743058
10PKN22.42713482
11EEF2K2.37956491
12PRPF4B2.02117830
13TESK21.91727607
14PRKD31.83465739
15TLK11.75245436
16MAP3K111.71294450
17MAP2K31.69976811
18MST1R1.68415351
19RIPK11.64957798
20TTN1.46488063
21PRKD21.40106256
22MUSK1.39979403
23TESK11.35993720
24MAPKAPK31.28517969
25MAP3K101.28247326
26PTK61.28165649
27RPS6KB21.26105137
28IRAK21.20974897
29PDPK11.17379430
30TAOK11.14861812
31MTOR1.09251020
32PIM21.06750396
33PAK41.05578657
34TAOK21.04482415
35FGFR41.04289951
36RPS6KA21.02969340
37LMTK21.01175177
38ARAF0.95403799
39SIK20.94869991
40ILK0.94741341
41PTK20.94466888
42EPHB20.93356577
43MAP2K20.89377455
44MAP3K30.86029161
45RPS6KL10.84204355
46RPS6KC10.84204355
47ABL20.82693610
48CDC42BPA0.79578429
49GRK60.77603654
50BRAF0.76720797
51TBK10.73778640
52BMX0.73552450
53MARK20.73292526
54MAP3K10.73012880
55DDR20.70614509
56MAPK110.69027615
57LRRK20.68493783
58DMPK0.66266156
59STK160.65435461
60TNK20.64892568
61RPS6KA60.64338628
62AURKA0.64176919
63HIPK20.60518469
64PRKG20.59523090
65PRKCI0.59194749
66MAP2K60.58411805
67CDK40.58357322
68BLK0.57560014
69DYRK1B0.55150672
70CDK120.55066081
71PDGFRA0.54283854
72MAP3K60.53998190
73WNK40.53449114
74CAMK1D0.51271589
75IRAK40.50552035
76STK380.50155824
77DAPK30.48439290
78MAPK120.46907954
79PHKG10.46029014
80PHKG20.46029014
81NEK20.45973200
82AKT20.45012163
83PRKD10.44627268
84CHUK0.42418421
85CDK70.42050074
86VRK20.40396103
87MET0.40217896
88BCKDK0.39637569
89MAP3K80.38711339
90STK40.37321599
91CAMK2G0.35939622
92TYRO30.35937898
93MAP4K10.35352510
94RPS6KA10.35228018
95PDK10.31850050
96PAK10.29591615
97MAP3K90.29455424
98MAP2K40.29338809
99MELK0.28649340
100MAPK40.27004226

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041225.33341701
2Other glycan degradation_Homo sapiens_hsa005113.33502575
3Fructose and mannose metabolism_Homo sapiens_hsa000513.27389346
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.75265778
5Cyanoamino acid metabolism_Homo sapiens_hsa004602.43583516
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.41937282
7Arginine biosynthesis_Homo sapiens_hsa002202.34999510
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.23965303
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.16715630
10Sulfur metabolism_Homo sapiens_hsa009201.84132496
11Vitamin B6 metabolism_Homo sapiens_hsa007501.81029341
12Biosynthesis of amino acids_Homo sapiens_hsa012301.77320704
13Galactose metabolism_Homo sapiens_hsa000521.73938248
14Phenylalanine metabolism_Homo sapiens_hsa003601.73229529
15Notch signaling pathway_Homo sapiens_hsa043301.64343343
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.61461321
17Ribosome_Homo sapiens_hsa030101.59479494
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.57897862
19VEGF signaling pathway_Homo sapiens_hsa043701.39905416
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38766156
21Pentose phosphate pathway_Homo sapiens_hsa000301.37829685
22Bladder cancer_Homo sapiens_hsa052191.35949811
23Pyruvate metabolism_Homo sapiens_hsa006201.32962248
24Lysosome_Homo sapiens_hsa041421.26772211
25Sphingolipid metabolism_Homo sapiens_hsa006001.24248433
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.23363529
27Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.18409490
28Central carbon metabolism in cancer_Homo sapiens_hsa052301.16758664
29PPAR signaling pathway_Homo sapiens_hsa033201.15733498
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12064573
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.09443518
32AMPK signaling pathway_Homo sapiens_hsa041521.09332003
33Insulin resistance_Homo sapiens_hsa049311.08541895
34Insulin signaling pathway_Homo sapiens_hsa049101.07692781
35Carbon metabolism_Homo sapiens_hsa012001.06823465
36Prion diseases_Homo sapiens_hsa050201.05560062
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05291167
38Vitamin digestion and absorption_Homo sapiens_hsa049771.02242311
39mTOR signaling pathway_Homo sapiens_hsa041501.00832921
40Acute myeloid leukemia_Homo sapiens_hsa052210.99232550
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94215919
42Arginine and proline metabolism_Homo sapiens_hsa003300.92869141
43Tyrosine metabolism_Homo sapiens_hsa003500.89807309
44Glutathione metabolism_Homo sapiens_hsa004800.88124374
45Chronic myeloid leukemia_Homo sapiens_hsa052200.87664800
46Fat digestion and absorption_Homo sapiens_hsa049750.87510802
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85828349
48Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81751915
49Fatty acid degradation_Homo sapiens_hsa000710.81198153
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81121589
51Adipocytokine signaling pathway_Homo sapiens_hsa049200.80814457
52Endometrial cancer_Homo sapiens_hsa052130.78993725
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78545753
54Lysine degradation_Homo sapiens_hsa003100.74608892
55Histidine metabolism_Homo sapiens_hsa003400.73927047
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73561789
57Non-small cell lung cancer_Homo sapiens_hsa052230.71044754
58Hepatitis C_Homo sapiens_hsa051600.70039778
59Bile secretion_Homo sapiens_hsa049760.69262902
60Folate biosynthesis_Homo sapiens_hsa007900.68884480
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68549021
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.66494980
63Vibrio cholerae infection_Homo sapiens_hsa051100.65237507
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64664677
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63660987
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63454219
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.62270391
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.61221933
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59202186
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.58612606
71Fatty acid metabolism_Homo sapiens_hsa012120.55811211
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55274083
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53395769
74N-Glycan biosynthesis_Homo sapiens_hsa005100.50898621
75Base excision repair_Homo sapiens_hsa034100.50756348
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48217677
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46195006
78Thyroid cancer_Homo sapiens_hsa052160.45988138
79Renal cell carcinoma_Homo sapiens_hsa052110.45940218
80Glucagon signaling pathway_Homo sapiens_hsa049220.44858891
81Inositol phosphate metabolism_Homo sapiens_hsa005620.44518942
82Metabolic pathways_Homo sapiens_hsa011000.42248574
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41725158
84Alcoholism_Homo sapiens_hsa050340.38788447
85Basal cell carcinoma_Homo sapiens_hsa052170.38081397
86Endocytosis_Homo sapiens_hsa041440.38038994
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37655401
88Pancreatic cancer_Homo sapiens_hsa052120.37608225
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37522996
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37455448
91Renin-angiotensin system_Homo sapiens_hsa046140.35724080
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.34999723
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.32864188
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32454731
95ErbB signaling pathway_Homo sapiens_hsa040120.32273037
96Complement and coagulation cascades_Homo sapiens_hsa046100.31692853
97Systemic lupus erythematosus_Homo sapiens_hsa053220.31085694
98Mineral absorption_Homo sapiens_hsa049780.30513607
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.30263079
100Pyrimidine metabolism_Homo sapiens_hsa002400.28551020

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