C8ORF76

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein prenylation (GO:0018342)6.06776515
2prenylation (GO:0097354)6.06776515
3proteasome assembly (GO:0043248)5.28629995
4positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.48135264
5positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.48135264
6positive regulation of mitotic sister chromatid separation (GO:1901970)4.48135264
7eosinophil chemotaxis (GO:0048245)4.45716980
8ribosomal small subunit assembly (GO:0000028)4.32523981
9piRNA metabolic process (GO:0034587)4.09583095
10eosinophil migration (GO:0072677)3.95853634
11DNA deamination (GO:0045006)3.92029759
12establishment of protein localization to mitochondrial membrane (GO:0090151)3.90573519
13L-fucose catabolic process (GO:0042355)3.79402289
14fucose catabolic process (GO:0019317)3.79402289
15L-fucose metabolic process (GO:0042354)3.79402289
16protein neddylation (GO:0045116)3.68264269
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.67175832
18pseudouridine synthesis (GO:0001522)3.60774241
19regulation of meiosis I (GO:0060631)3.55365424
20preassembly of GPI anchor in ER membrane (GO:0016254)3.54741145
21protein complex biogenesis (GO:0070271)3.53121731
22respiratory chain complex IV assembly (GO:0008535)3.52574012
23tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.45070615
24RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.45070615
25mitochondrial respiratory chain complex assembly (GO:0033108)3.43637351
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.38309028
27mitochondrial respiratory chain complex I assembly (GO:0032981)3.37710211
28NADH dehydrogenase complex assembly (GO:0010257)3.37710211
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.37710211
30chromatin remodeling at centromere (GO:0031055)3.34539832
31peptidyl-histidine modification (GO:0018202)3.31048874
32regulation of sister chromatid cohesion (GO:0007063)3.30876493
33energy coupled proton transport, down electrochemical gradient (GO:0015985)3.30684411
34ATP synthesis coupled proton transport (GO:0015986)3.30684411
35mitochondrial RNA metabolic process (GO:0000959)3.29336089
36regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.27389195
37pteridine-containing compound biosynthetic process (GO:0042559)3.24672700
38positive regulation of chromosome segregation (GO:0051984)3.23745992
39negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.22060220
40cytochrome complex assembly (GO:0017004)3.19860623
41regulation of mononuclear cell migration (GO:0071675)3.16888384
42CENP-A containing nucleosome assembly (GO:0034080)3.14768622
43organelle membrane fusion (GO:0090174)3.09173091
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.06978400
45termination of RNA polymerase III transcription (GO:0006386)3.06978400
46protein K6-linked ubiquitination (GO:0085020)3.05999516
47metallo-sulfur cluster assembly (GO:0031163)3.04447094
48iron-sulfur cluster assembly (GO:0016226)3.04447094
49positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.04423118
50respiratory electron transport chain (GO:0022904)3.00691489
51DNA demethylation (GO:0080111)2.99579337
52negative regulation of T cell receptor signaling pathway (GO:0050860)2.98962152
53regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.98956961
54intracellular protein transmembrane import (GO:0044743)2.97778594
55C-terminal protein lipidation (GO:0006501)2.97655290
56electron transport chain (GO:0022900)2.97537136
577-methylguanosine mRNA capping (GO:0006370)2.97365268
58double-strand break repair via nonhomologous end joining (GO:0006303)2.96979094
59non-recombinational repair (GO:0000726)2.96979094
60recombinational repair (GO:0000725)2.95042891
61tRNA processing (GO:0008033)2.95040812
62double-strand break repair via homologous recombination (GO:0000724)2.93141784
63water-soluble vitamin biosynthetic process (GO:0042364)2.92610304
64regulation of cellular amino acid metabolic process (GO:0006521)2.92351855
65exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.92330531
66negative regulation of ligase activity (GO:0051352)2.92150858
67negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.92150858
68somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.91295919
69isotype switching (GO:0045190)2.91295919
70somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.91295919
71replication fork processing (GO:0031297)2.91268829
727-methylguanosine RNA capping (GO:0009452)2.88595155
73RNA capping (GO:0036260)2.88595155
74platelet dense granule organization (GO:0060155)2.87252482
75DNA double-strand break processing (GO:0000729)2.86837416
76nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.86054322
77protein-cofactor linkage (GO:0018065)2.83643551
78negative regulation of Ras GTPase activity (GO:0034261)2.82280085
79DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.79407966
80regulation of mitochondrial translation (GO:0070129)2.78683870
81signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.77207691
82signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.77207691
83signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.77207691
84membrane budding (GO:0006900)2.76551403
85anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.75053516
86folic acid-containing compound biosynthetic process (GO:0009396)2.73418978
87RNA methylation (GO:0001510)2.72137247
88oxidative demethylation (GO:0070989)2.69881285
89tRNA modification (GO:0006400)2.69629335
90signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.69513042
91intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.69513042
92positive regulation of calcium ion import (GO:0090280)2.68219237
93negative regulation of DNA-dependent DNA replication (GO:2000104)2.68138770
94cullin deneddylation (GO:0010388)2.67869558
95C-terminal protein amino acid modification (GO:0018410)2.66269477
96synapsis (GO:0007129)2.66085802
97DNA catabolic process, exonucleolytic (GO:0000738)2.65439513
98chaperone-mediated protein transport (GO:0072321)2.64271875
99autophagic vacuole fusion (GO:0000046)2.63669508
100telomere maintenance via recombination (GO:0000722)2.63621325

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.18180442
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.89758842
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.39590046
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.43483519
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.22184666
6VDR_22108803_ChIP-Seq_LS180_Human3.05859076
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.02988340
8ZNF274_21170338_ChIP-Seq_K562_Hela3.00961457
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.87313984
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.72204335
11VDR_23849224_ChIP-Seq_CD4+_Human2.59367874
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.58460107
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.58185509
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.57395550
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.55430152
16ELK1_19687146_ChIP-ChIP_HELA_Human2.55345774
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.48489089
18GATA1_22025678_ChIP-Seq_K562_Human2.45563997
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.29423891
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.28513100
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.18706682
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.03895418
23FOXP3_21729870_ChIP-Seq_TREG_Human2.03471164
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99217658
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.98045486
26DCP1A_22483619_ChIP-Seq_HELA_Human1.88059792
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.83040282
28IRF1_19129219_ChIP-ChIP_H3396_Human1.71353596
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.71146035
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70658445
31* GABP_19822575_ChIP-Seq_HepG2_Human1.68505043
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.65447054
33MYC_18940864_ChIP-ChIP_HL60_Human1.62924695
34E2F7_22180533_ChIP-Seq_HELA_Human1.57102343
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56336114
36PADI4_21655091_ChIP-ChIP_MCF-7_Human1.52329445
37FUS_26573619_Chip-Seq_HEK293_Human1.51629340
38RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49915136
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44487972
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.44007757
41MYC_19030024_ChIP-ChIP_MESCs_Mouse1.42920549
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41153935
43TP53_22573176_ChIP-Seq_HFKS_Human1.39478987
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38724519
45EWS_26573619_Chip-Seq_HEK293_Human1.38380042
46EGR1_23403033_ChIP-Seq_LIVER_Mouse1.37807715
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36814404
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33827736
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32296907
50HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.26866708
51FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24871961
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.24871961
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24820465
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23283040
55GBX2_23144817_ChIP-Seq_PC3_Human1.22771928
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.21992973
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21958553
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19723985
59TTF2_22483619_ChIP-Seq_HELA_Human1.14890664
60P300_19829295_ChIP-Seq_ESCs_Human1.12668855
61NELFA_20434984_ChIP-Seq_ESCs_Mouse1.12435487
62IGF1R_20145208_ChIP-Seq_DFB_Human1.11140838
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09164285
64HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08500075
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07459036
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06900009
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06076773
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.04900214
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04578539
70NANOG_19829295_ChIP-Seq_ESCs_Human1.04435182
71SOX2_19829295_ChIP-Seq_ESCs_Human1.04435182
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03584148
73IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.03324284
74AR_20517297_ChIP-Seq_VCAP_Human1.02329948
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02146469
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01985451
77YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01373671
78BCAT_22108803_ChIP-Seq_LS180_Human1.01191251
79SALL1_21062744_ChIP-ChIP_HESCs_Human1.00927739
80TAF15_26573619_Chip-Seq_HEK293_Human0.99239564
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96092938
82EZH2_27294783_Chip-Seq_NPCs_Mouse0.95642564
83MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94888629
84* ER_23166858_ChIP-Seq_MCF-7_Human0.94453001
85* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93358425
86GATA3_21878914_ChIP-Seq_MCF-7_Human0.92085362
87PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91124121
88FOXM1_23109430_ChIP-Seq_U2OS_Human0.90157262
89HTT_18923047_ChIP-ChIP_STHdh_Human0.89513454
90ERG_20517297_ChIP-Seq_VCAP_Human0.88717630
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87518421
92ELK1_22589737_ChIP-Seq_MCF10A_Human0.86096971
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85275475
94FOXH1_21741376_ChIP-Seq_EPCs_Human0.83334751
95ERG_20887958_ChIP-Seq_HPC-7_Mouse0.82692975
96CBP_20019798_ChIP-Seq_JUKART_Human0.81952734
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.81952734
98CRX_20693478_ChIP-Seq_RETINA_Mouse0.80785309
99KLF5_20875108_ChIP-Seq_MESCs_Mouse0.80144917
100CTBP2_25329375_ChIP-Seq_LNCAP_Human0.79709935

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis4.07832965
2MP0003195_calcinosis3.45331972
3MP0008058_abnormal_DNA_repair3.29406913
4MP0003806_abnormal_nucleotide_metabolis3.18358093
5MP0008877_abnormal_DNA_methylation3.03804785
6MP0000569_abnormal_digit_pigmentation2.64716860
7MP0003303_peritoneal_inflammation2.63483947
8MP0003718_maternal_effect2.63269754
9MP0008875_abnormal_xenobiotic_pharmacok2.48758142
10MP0003186_abnormal_redox_activity2.33595445
11MP0002938_white_spotting2.31921098
12MP0002837_dystrophic_cardiac_calcinosis2.26301011
13MP0006082_CNS_inflammation2.16804951
14MP0005075_abnormal_melanosome_morpholog2.09136043
15MP0005408_hypopigmentation2.07545016
16MP0001293_anophthalmia2.02019341
17MP0003693_abnormal_embryo_hatching2.01185416
18MP0000372_irregular_coat_pigmentation1.97263150
19MP0009697_abnormal_copulation1.93768854
20MP0010094_abnormal_chromosome_stability1.92874247
21MP0002254_reproductive_system_inflammat1.91627392
22MP0001919_abnormal_reproductive_system1.85131505
23MP0001764_abnormal_homeostasis1.84903857
24MP0006292_abnormal_olfactory_placode1.82375848
25MP0002102_abnormal_ear_morphology1.66447852
26MP0008007_abnormal_cellular_replicative1.66097218
27MP0002638_abnormal_pupillary_reflex1.65350227
28MP0006035_abnormal_mitochondrial_morpho1.64712389
29MP0003786_premature_aging1.62855184
30MP0000383_abnormal_hair_follicle1.62707468
31MP0005551_abnormal_eye_electrophysiolog1.59056232
32MP0005645_abnormal_hypothalamus_physiol1.54984823
33MP0002751_abnormal_autonomic_nervous1.54040328
34MP0006036_abnormal_mitochondrial_physio1.50519140
35MP0000358_abnormal_cell_content/1.50155012
36MP0003077_abnormal_cell_cycle1.45055089
37MP0005253_abnormal_eye_physiology1.44724634
38MP0010678_abnormal_skin_adnexa1.44373754
39MP0005174_abnormal_tail_pigmentation1.42550234
40MP0005389_reproductive_system_phenotype1.41881992
41MP0004147_increased_porphyrin_level1.41505193
42MP0002210_abnormal_sex_determination1.38807758
43MP0005379_endocrine/exocrine_gland_phen1.38502910
44MP0002277_abnormal_respiratory_mucosa1.36037715
45MP0006072_abnormal_retinal_apoptosis1.33531564
46MP0002139_abnormal_hepatobiliary_system1.26529827
47MP0005084_abnormal_gallbladder_morpholo1.26524645
48MP0008872_abnormal_physiological_respon1.26126101
49MP0003890_abnormal_embryonic-extraembry1.21370980
50MP0002653_abnormal_ependyma_morphology1.19639678
51MP0001529_abnormal_vocalization1.18638424
52MP0003950_abnormal_plasma_membrane1.17926813
53MP0002876_abnormal_thyroid_physiology1.17640706
54MP0002163_abnormal_gland_morphology1.14130568
55MP0003111_abnormal_nucleus_morphology1.11797761
56MP0003646_muscle_fatigue1.08032811
57MP0003937_abnormal_limbs/digits/tail_de1.07583856
58MP0001663_abnormal_digestive_system1.07421242
59MP0005410_abnormal_fertilization1.07234120
60MP0001929_abnormal_gametogenesis1.06111959
61MP0004957_abnormal_blastocyst_morpholog1.05033388
62MP0009046_muscle_twitch1.04463793
63MP0010386_abnormal_urinary_bladder1.02791714
64MP0008932_abnormal_embryonic_tissue1.01835477
65MP0004043_abnormal_pH_regulation1.00868484
66MP0002090_abnormal_vision0.99309729
67MP0001324_abnormal_eye_pigmentation0.98818370
68MP0000653_abnormal_sex_gland0.98679394
69MP0004142_abnormal_muscle_tone0.98080541
70MP0005167_abnormal_blood-brain_barrier0.97970347
71MP0000015_abnormal_ear_pigmentation0.95693554
72MP0003011_delayed_dark_adaptation0.95309019
73MP0000427_abnormal_hair_cycle0.93514437
74MP0001145_abnormal_male_reproductive0.93467885
75MP0005332_abnormal_amino_acid0.90958273
76MP0001119_abnormal_female_reproductive0.90252579
77MP0002148_abnormal_hypersensitivity_rea0.86586949
78MP0002095_abnormal_skin_pigmentation0.85685619
79MP0009785_altered_susceptibility_to0.85602273
80MP0005391_vision/eye_phenotype0.85347845
81MP0001664_abnormal_digestion0.79488136
82MP0005395_other_phenotype0.79123178
83MP0005195_abnormal_posterior_eye0.78140500
84MP0001905_abnormal_dopamine_level0.76798814
85MP0003698_abnormal_male_reproductive0.75349293
86MP0001485_abnormal_pinna_reflex0.75042699
87MP0005266_abnormal_metabolism0.73624407
88MP0004742_abnormal_vestibular_system0.73231818
89MP0000647_abnormal_sebaceous_gland0.72872881
90MP0001944_abnormal_pancreas_morphology0.72507948
91MP0002693_abnormal_pancreas_physiology0.69544552
92MP0003136_yellow_coat_color0.69409983
93MP0008789_abnormal_olfactory_epithelium0.69348042
94MP0003936_abnormal_reproductive_system0.69306751
95MP0009764_decreased_sensitivity_to0.69281043
96MP0004019_abnormal_vitamin_homeostasis0.69104703
97MP0000467_abnormal_esophagus_morphology0.68782464
98MP0000516_abnormal_urinary_system0.67202685
99MP0005367_renal/urinary_system_phenotyp0.67202685
100MP0005647_abnormal_sex_gland0.66616144

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.16207261
2Abnormal mitochondria in muscle tissue (HP:0008316)3.82551955
3Acute encephalopathy (HP:0006846)3.78210455
4Mitochondrial inheritance (HP:0001427)3.77679086
5Increased CSF lactate (HP:0002490)3.76384998
6Progressive macrocephaly (HP:0004481)3.52124649
7Increased hepatocellular lipid droplets (HP:0006565)3.35577168
8Cerebral edema (HP:0002181)3.11495704
9Congenital stationary night blindness (HP:0007642)3.09244996
10Lipid accumulation in hepatocytes (HP:0006561)3.06424628
11Long foot (HP:0001833)2.99642426
12Pancreatic cysts (HP:0001737)2.97117204
13Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.84776245
14Lactic acidosis (HP:0003128)2.84704132
15Abnormality of midbrain morphology (HP:0002418)2.84310288
16Molar tooth sign on MRI (HP:0002419)2.84310288
17Hypoplastic pelvis (HP:0008839)2.83052073
18Duplicated collecting system (HP:0000081)2.81316958
19Hepatic necrosis (HP:0002605)2.79571512
20Pancreatic fibrosis (HP:0100732)2.79225325
21Abnormality of the renal collecting system (HP:0004742)2.78526298
22Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.75687404
23Hepatocellular necrosis (HP:0001404)2.74513433
24Renal Fanconi syndrome (HP:0001994)2.72864522
25True hermaphroditism (HP:0010459)2.71831844
26Nephronophthisis (HP:0000090)2.67437940
27Birth length less than 3rd percentile (HP:0003561)2.61283512
28Increased serum lactate (HP:0002151)2.60189091
29Adactyly (HP:0009776)2.59420046
30Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.48164544
313-Methylglutaconic aciduria (HP:0003535)2.48099429
32Abnormal rod and cone electroretinograms (HP:0008323)2.46596376
33Severe visual impairment (HP:0001141)2.41797720
34Abnormal number of erythroid precursors (HP:0012131)2.32797511
35Exercise intolerance (HP:0003546)2.28317550
36Respiratory failure (HP:0002878)2.28134995
37Large for gestational age (HP:0001520)2.24886642
38Decreased activity of mitochondrial respiratory chain (HP:0008972)2.23971423
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.23971423
40Type II lissencephaly (HP:0007260)2.22134601
41Optic disc pallor (HP:0000543)2.20972482
42Abnormality of the renal cortex (HP:0011035)2.20437223
43Aplasia/hypoplasia of the uterus (HP:0008684)2.19121068
44Abnormal ciliary motility (HP:0012262)2.17447017
45Exertional dyspnea (HP:0002875)2.15641292
46Acute lymphatic leukemia (HP:0006721)2.15064535
47Abnormality of B cell number (HP:0010975)2.15017904
48Abnormality of the renal medulla (HP:0100957)2.14894969
49Abnormal respiratory motile cilium physiology (HP:0012261)2.12088749
50Abnormality of cells of the erythroid lineage (HP:0012130)2.11864270
51Methylmalonic aciduria (HP:0012120)2.10710733
52Tubular atrophy (HP:0000092)2.10001530
53Generalized aminoaciduria (HP:0002909)2.07590326
54B lymphocytopenia (HP:0010976)2.05615205
55Albinism (HP:0001022)2.02947623
56Absent/shortened dynein arms (HP:0200106)2.02546201
57Dynein arm defect of respiratory motile cilia (HP:0012255)2.02546201
58Microvesicular hepatic steatosis (HP:0001414)2.02414001
59Abnormality of alanine metabolism (HP:0010916)2.00591598
60Hyperalaninemia (HP:0003348)2.00591598
61Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.00591598
62IgM deficiency (HP:0002850)1.99315596
63Increased intramyocellular lipid droplets (HP:0012240)1.99170894
64Lethargy (HP:0001254)1.97875372
65Aplasia/Hypoplasia of the tongue (HP:0010295)1.94945649
66Methylmalonic acidemia (HP:0002912)1.93632452
67Rhinitis (HP:0012384)1.93478906
68Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91854408
69Chronic hepatic failure (HP:0100626)1.91619693
70Abnormal respiratory epithelium morphology (HP:0012253)1.91144672
71Abnormal respiratory motile cilium morphology (HP:0005938)1.91144672
72Absent rod-and cone-mediated responses on ERG (HP:0007688)1.90732392
73Aplasia/Hypoplasia of the uvula (HP:0010293)1.90150380
74Glycosuria (HP:0003076)1.89544733
75Abnormality of urine glucose concentration (HP:0011016)1.89544733
76Abnormality of fatty-acid metabolism (HP:0004359)1.89321191
77Poor head control (HP:0002421)1.88585567
78Fibular aplasia (HP:0002990)1.87884947
79Abnormality of chromosome stability (HP:0003220)1.87670918
80Pendular nystagmus (HP:0012043)1.87269778
81CNS demyelination (HP:0007305)1.86195671
82Decreased central vision (HP:0007663)1.85943130
83Meckel diverticulum (HP:0002245)1.85502860
84Abnormality of the pons (HP:0007361)1.84287141
85Oligodactyly (hands) (HP:0001180)1.80961820
86Severe muscular hypotonia (HP:0006829)1.80918351
87Aplasia/Hypoplasia of the fovea (HP:0008060)1.79445031
88Hypoplasia of the fovea (HP:0007750)1.79445031
89Type I transferrin isoform profile (HP:0003642)1.78451608
90Hypoplasia of the pons (HP:0012110)1.76087622
91Congenital, generalized hypertrichosis (HP:0004540)1.75491001
92Clubbing of toes (HP:0100760)1.74928569
93Sclerocornea (HP:0000647)1.74428252
94Abnormality of renal resorption (HP:0011038)1.74163055
95Abnormality of the ileum (HP:0001549)1.73162971
96Male pseudohermaphroditism (HP:0000037)1.72804394
97Hyperglycinemia (HP:0002154)1.70770956
98Abnormality of the preputium (HP:0100587)1.70601963
99Decreased electroretinogram (ERG) amplitude (HP:0000654)1.68423516
100Leukodystrophy (HP:0002415)1.68331447

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK26.66214579
2MKNK14.42549891
3ACVR1B3.77645880
4ZAK2.96705715
5BMPR1B2.59376859
6TAOK22.58963707
7MST42.46975008
8STK162.15610674
9WNK32.15503309
10TAOK12.14638803
11MAP4K22.00215004
12BUB11.97765983
13FRK1.96956854
14PBK1.90604311
15TRIM281.87701802
16SRPK11.78770028
17EIF2AK31.78270562
18VRK21.72013339
19ADRBK21.62590665
20ABL21.51173044
21MAP3K31.48615462
22MAP3K111.41040291
23PLK41.39028763
24NUAK11.37827397
25TTK1.30955254
26EIF2AK11.24745545
27NEK11.23324730
28NME21.21045945
29MAP3K121.20835963
30GRK11.18029162
31WEE11.16723476
32VRK11.16433789
33PLK31.09708134
34BRSK21.08377209
35BCKDK1.08131250
36JAK31.04810917
37CSNK1G11.04327573
38CHEK21.02723969
39PTK2B1.02121285
40MAP2K31.01389935
41ARAF0.98212140
42WNK40.95397762
43CSNK1G30.94258744
44PNCK0.91113408
45PLK10.89389851
46TGFBR10.86610312
47CDC70.86564670
48TLK10.85930489
49PRKCI0.85428933
50MAP3K90.83811817
51DAPK20.77376929
52CSNK1G20.74154915
53STK390.73518372
54TSSK60.68044667
55CSNK1A1L0.66315620
56GRK70.65379245
57IKBKB0.64077336
58MAP3K50.62788062
59TXK0.62320040
60DYRK1A0.60854619
61MAP3K40.58732580
62PLK20.58341840
63MATK0.58031412
64LIMK10.57878310
65BCR0.57162913
66INSRR0.53691186
67STK30.53600320
68CCNB10.52635256
69ADRBK10.50941809
70ATR0.49614970
71NME10.49039810
72MAP2K60.45004992
73STK38L0.43885967
74CSNK1A10.41244553
75PRKCG0.40439275
76RPS6KA50.40089118
77CSNK2A10.39603631
78AURKB0.38151638
79OXSR10.36741104
80PASK0.34081694
81DYRK20.33869510
82AURKA0.33505223
83BRAF0.33385785
84CSNK2A20.31704367
85MUSK0.30178625
86PINK10.29549785
87PRKCQ0.29445979
88ERBB30.29415941
89PDK20.29371510
90PIM20.29101496
91TNIK0.28713647
92STK40.28412424
93MAP3K80.28080249
94ERBB40.27463464
95PAK30.26645915
96CASK0.26157865
97IRAK30.25542614
98CAMKK20.24024508
99PHKG10.23845696
100PHKG20.23845696

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.78668797
2Oxidative phosphorylation_Homo sapiens_hsa001903.34188345
3RNA polymerase_Homo sapiens_hsa030202.80591513
4Protein export_Homo sapiens_hsa030602.66540201
5Parkinsons disease_Homo sapiens_hsa050122.60906557
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.53684576
7Homologous recombination_Homo sapiens_hsa034402.30645134
8Ribosome_Homo sapiens_hsa030102.30580253
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.06282288
10SNARE interactions in vesicular transport_Homo sapiens_hsa041302.00607572
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.98978728
12Propanoate metabolism_Homo sapiens_hsa006401.98293499
13Fanconi anemia pathway_Homo sapiens_hsa034601.96958434
14Huntingtons disease_Homo sapiens_hsa050161.95590666
15Basal transcription factors_Homo sapiens_hsa030221.92892152
16Fatty acid elongation_Homo sapiens_hsa000621.89017245
17Nucleotide excision repair_Homo sapiens_hsa034201.88601876
18Mismatch repair_Homo sapiens_hsa034301.82072533
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.77874815
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.70873087
21One carbon pool by folate_Homo sapiens_hsa006701.69881422
22DNA replication_Homo sapiens_hsa030301.64094239
23Base excision repair_Homo sapiens_hsa034101.63666506
24Non-homologous end-joining_Homo sapiens_hsa034501.59618390
25Alzheimers disease_Homo sapiens_hsa050101.58425410
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55961641
27RNA transport_Homo sapiens_hsa030131.53158797
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.52303962
29Pyrimidine metabolism_Homo sapiens_hsa002401.51645441
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50436267
31Butanoate metabolism_Homo sapiens_hsa006501.48029234
32Folate biosynthesis_Homo sapiens_hsa007901.44658031
33RNA degradation_Homo sapiens_hsa030181.41419197
34Caffeine metabolism_Homo sapiens_hsa002321.40759725
35Selenocompound metabolism_Homo sapiens_hsa004501.36957189
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.30178884
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.25080126
38Collecting duct acid secretion_Homo sapiens_hsa049661.25036641
39Steroid biosynthesis_Homo sapiens_hsa001001.24532597
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.21734543
41Tryptophan metabolism_Homo sapiens_hsa003801.17644916
42Purine metabolism_Homo sapiens_hsa002301.15386210
43beta-Alanine metabolism_Homo sapiens_hsa004101.14563696
44Linoleic acid metabolism_Homo sapiens_hsa005911.14255243
45Peroxisome_Homo sapiens_hsa041461.07922645
46Sulfur metabolism_Homo sapiens_hsa009201.07219053
47Phototransduction_Homo sapiens_hsa047441.06494013
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05984761
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00651883
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99966864
51Glutathione metabolism_Homo sapiens_hsa004800.98204890
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95159317
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89770419
54Spliceosome_Homo sapiens_hsa030400.89719803
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89434323
56Metabolic pathways_Homo sapiens_hsa011000.87061279
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83806898
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.83430930
59Rheumatoid arthritis_Homo sapiens_hsa053230.83333335
60Ether lipid metabolism_Homo sapiens_hsa005650.78508749
61Cardiac muscle contraction_Homo sapiens_hsa042600.76991068
62Nitrogen metabolism_Homo sapiens_hsa009100.75316900
63Regulation of autophagy_Homo sapiens_hsa041400.73036855
64Cell cycle_Homo sapiens_hsa041100.72732389
65Chemical carcinogenesis_Homo sapiens_hsa052040.68274291
66Pyruvate metabolism_Homo sapiens_hsa006200.67733521
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67379670
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66243451
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65959860
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65900741
71Fatty acid degradation_Homo sapiens_hsa000710.65820239
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.64820611
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64321620
74Primary immunodeficiency_Homo sapiens_hsa053400.60511058
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58671719
76p53 signaling pathway_Homo sapiens_hsa041150.58084290
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56677620
78Sulfur relay system_Homo sapiens_hsa041220.56515242
79Systemic lupus erythematosus_Homo sapiens_hsa053220.56029794
80Retinol metabolism_Homo sapiens_hsa008300.54384311
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53372669
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52610258
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.50794155
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.50076888
85Fatty acid metabolism_Homo sapiens_hsa012120.49670437
86Arachidonic acid metabolism_Homo sapiens_hsa005900.49617289
87Glycerolipid metabolism_Homo sapiens_hsa005610.48394325
88Asthma_Homo sapiens_hsa053100.45247896
89Type I diabetes mellitus_Homo sapiens_hsa049400.42387057
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40763012
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30777029
92Fatty acid biosynthesis_Homo sapiens_hsa000610.26407043
93Arginine and proline metabolism_Homo sapiens_hsa003300.25916576
94Oocyte meiosis_Homo sapiens_hsa041140.25542799
95Sphingolipid metabolism_Homo sapiens_hsa006000.25082161
96Carbon metabolism_Homo sapiens_hsa012000.24617283
97Lysosome_Homo sapiens_hsa041420.22112721
98Taste transduction_Homo sapiens_hsa047420.19041868
99Epstein-Barr virus infection_Homo sapiens_hsa051690.18807039
100mRNA surveillance pathway_Homo sapiens_hsa030150.18500738

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