C8ORF46

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)7.75509367
2synaptic vesicle docking involved in exocytosis (GO:0016081)7.74256974
3glutamate secretion (GO:0014047)6.94889274
4regulation of short-term neuronal synaptic plasticity (GO:0048172)6.34980031
5synaptic vesicle exocytosis (GO:0016079)6.31442852
6regulation of synaptic vesicle exocytosis (GO:2000300)6.16110074
7cellular potassium ion homeostasis (GO:0030007)5.77805976
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.77154825
9regulation of synaptic vesicle transport (GO:1902803)5.47695889
10L-amino acid import (GO:0043092)5.44241761
11membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.38499446
12sodium ion export (GO:0071436)5.35463526
13central nervous system myelination (GO:0022010)5.26380209
14axon ensheathment in central nervous system (GO:0032291)5.26380209
15neurotransmitter secretion (GO:0007269)5.10914555
16locomotory exploration behavior (GO:0035641)5.09696292
17regulation of neuronal synaptic plasticity (GO:0048168)4.91933688
18vocalization behavior (GO:0071625)4.91344887
19amino acid import (GO:0043090)4.88579221
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.73917766
21neuronal ion channel clustering (GO:0045161)4.73306818
22regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.66418251
23dendritic spine morphogenesis (GO:0060997)4.60835152
24ionotropic glutamate receptor signaling pathway (GO:0035235)4.54785405
25neuronal action potential propagation (GO:0019227)4.52830052
26protein localization to synapse (GO:0035418)4.50253641
27exploration behavior (GO:0035640)4.49289084
28postsynaptic membrane organization (GO:0001941)4.37957277
29regulation of long-term neuronal synaptic plasticity (GO:0048169)4.32196073
30neurotransmitter transport (GO:0006836)4.30494264
31activation of protein kinase A activity (GO:0034199)4.28528181
32regulation of glutamate receptor signaling pathway (GO:1900449)4.26703873
33cerebellar granule cell differentiation (GO:0021707)4.23854229
34potassium ion homeostasis (GO:0055075)4.22981360
35positive regulation of membrane potential (GO:0045838)4.17843774
36potassium ion import (GO:0010107)4.13433222
37synaptic transmission, glutamatergic (GO:0035249)4.11302663
38positive regulation of dendritic spine development (GO:0060999)4.10733649
39cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.08553683
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.06451886
41negative regulation of synaptic transmission, GABAergic (GO:0032229)4.04727472
42neuron cell-cell adhesion (GO:0007158)3.99127477
43positive regulation of synapse maturation (GO:0090129)3.93606034
44neuron-neuron synaptic transmission (GO:0007270)3.93559175
45regulation of synapse structural plasticity (GO:0051823)3.91362002
46regulation of neurotransmitter secretion (GO:0046928)3.91065519
47regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.88643600
48neurotransmitter-gated ion channel clustering (GO:0072578)3.84635006
49regulation of synaptic plasticity (GO:0048167)3.81100358
50regulation of neurotransmitter levels (GO:0001505)3.79109101
51regulation of voltage-gated calcium channel activity (GO:1901385)3.77775866
52neuromuscular process controlling balance (GO:0050885)3.74223367
53acidic amino acid transport (GO:0015800)3.72228207
54regulation of excitatory postsynaptic membrane potential (GO:0060079)3.71012771
55regulation of neurotransmitter transport (GO:0051588)3.64842635
56neurotransmitter uptake (GO:0001504)3.62582697
57negative regulation of dendrite morphogenesis (GO:0050774)3.60365568
58glutamate receptor signaling pathway (GO:0007215)3.58331366
59cell communication by electrical coupling (GO:0010644)3.57684281
60long-term memory (GO:0007616)3.57480431
61synaptic vesicle endocytosis (GO:0048488)3.54840658
62gamma-aminobutyric acid transport (GO:0015812)3.54224214
63cellular sodium ion homeostasis (GO:0006883)3.53825282
64dendritic spine organization (GO:0097061)3.52418463
65positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.47966850
66gamma-aminobutyric acid signaling pathway (GO:0007214)3.46514253
67presynaptic membrane organization (GO:0097090)3.46019777
68regulation of dendritic spine development (GO:0060998)3.44172360
69regulation of postsynaptic membrane potential (GO:0060078)3.42425831
70positive regulation of neurotransmitter secretion (GO:0001956)3.42168148
71regulation of dendritic spine morphogenesis (GO:0061001)3.35560293
72neuromuscular synaptic transmission (GO:0007274)3.34814149
73positive regulation of neurotransmitter transport (GO:0051590)3.33780534
74L-glutamate transport (GO:0015813)3.32547295
75presynaptic membrane assembly (GO:0097105)3.32030653
76layer formation in cerebral cortex (GO:0021819)3.31088892
77regulation of ARF protein signal transduction (GO:0032012)3.29596165
78regulation of vesicle fusion (GO:0031338)3.23118112
79neuromuscular process controlling posture (GO:0050884)3.21738796
80cytoskeletal anchoring at plasma membrane (GO:0007016)3.21301633
81long-term synaptic potentiation (GO:0060291)3.18784939
82positive regulation of dendritic spine morphogenesis (GO:0061003)3.18626692
83synaptic transmission (GO:0007268)3.18455330
84cerebellar Purkinje cell differentiation (GO:0021702)3.16404024
85regulation of synaptic transmission (GO:0050804)3.16299242
86response to auditory stimulus (GO:0010996)3.16261370
87chemosensory behavior (GO:0007635)3.15462205
88G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.15361221
89auditory behavior (GO:0031223)3.14580913
90regulation of synapse maturation (GO:0090128)3.11006861
91membrane depolarization during action potential (GO:0086010)3.09835668
92membrane depolarization (GO:0051899)3.08932379
93transmission of nerve impulse (GO:0019226)3.06458427
94regulation of cell communication by electrical coupling (GO:0010649)3.03216413
95positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.00458880
96proline transport (GO:0015824)2.99306428
97regulation of synaptic transmission, glutamatergic (GO:0051966)2.97227244
98detection of calcium ion (GO:0005513)2.95274463
99neuromuscular process (GO:0050905)2.94322391
100potassium ion transmembrane transport (GO:0071805)2.92118898

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.50412139
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.16478556
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.15060967
4REST_21632747_ChIP-Seq_MESCs_Mouse3.13484813
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12677602
6DROSHA_22980978_ChIP-Seq_HELA_Human3.03242077
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.95129627
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.88102872
9SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.75950492
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.74493619
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.72729986
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.62079386
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.62079386
14RNF2_27304074_Chip-Seq_ESCs_Mouse2.59566383
15REST_18959480_ChIP-ChIP_MESCs_Mouse2.57325774
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.55832091
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49896732
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.48313508
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.47713541
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41816978
21GBX2_23144817_ChIP-Seq_PC3_Human2.41582942
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.39864840
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.38557646
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.35387568
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.30917604
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.18670559
27AR_21572438_ChIP-Seq_LNCaP_Human2.17834934
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.05451543
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.97755995
30RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.75020138
31RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.68719194
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64959177
33DNAJC2_21179169_ChIP-ChIP_NT2_Human1.63699426
34RING1B_27294783_Chip-Seq_ESCs_Mouse1.48009242
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44752157
36KDM2B_26808549_Chip-Seq_K562_Human1.42389102
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.40777046
38NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40277782
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36516870
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.24878418
41WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24454417
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21612185
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20913470
44RNF2_27304074_Chip-Seq_NSC_Mouse1.19076753
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.17580691
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16729249
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15597838
48CTCF_27219007_Chip-Seq_Bcells_Human1.14721057
49ZFP281_27345836_Chip-Seq_ESCs_Mouse1.13957584
50EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13175638
51TET1_21490601_ChIP-Seq_MESCs_Mouse1.12006760
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09714798
53RING1B_27294783_Chip-Seq_NPCs_Mouse1.07082233
54AR_19668381_ChIP-Seq_PC3_Human1.06701672
55OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06687229
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05293352
57IGF1R_20145208_ChIP-Seq_DFB_Human1.04411098
58SMAD4_21799915_ChIP-Seq_A2780_Human1.03611440
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01514506
60WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00827241
61TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99740805
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99625114
63SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98482641
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98420227
65ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97876082
66SOX2_21211035_ChIP-Seq_LN229_Gbm0.96890878
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96469795
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96276271
69SMAD3_21741376_ChIP-Seq_EPCs_Human0.96249643
70MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94973045
71EGR1_19032775_ChIP-ChIP_M12_Human0.94811140
72TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94102970
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.93934034
74SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92564486
75GATA1_26923725_Chip-Seq_HPCs_Mouse0.92296592
76CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91932034
77YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91325325
78EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90398509
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89136079
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86645305
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86645305
82GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86613777
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86154452
84CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85034826
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.83877975
86SMAD3_21741376_ChIP-Seq_HESCs_Human0.81741525
87SMAD4_21741376_ChIP-Seq_HESCs_Human0.81627152
88LXR_22292898_ChIP-Seq_THP-1_Human0.81413413
89DPY_21335234_ChIP-Seq_ESCs_Mouse0.80659312
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80377753
91PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.79177460
92LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76698951
93SMAD3_21741376_ChIP-Seq_ESCs_Human0.76287811
94SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75811488
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.75554149
96TP53_20018659_ChIP-ChIP_R1E_Mouse0.75201756
97BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75064711
98GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74847629
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74666380
100KDM2B_26808549_Chip-Seq_SUP-B15_Human0.74239201

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.42176451
2MP0003880_abnormal_central_pattern5.71035097
3MP0005423_abnormal_somatic_nervous4.55163836
4MP0004270_analgesia4.43262062
5MP0003635_abnormal_synaptic_transmissio3.98473383
6MP0002064_seizures3.68853238
7MP0009745_abnormal_behavioral_response3.26006798
8MP0002063_abnormal_learning/memory/cond3.20970665
9MP0001486_abnormal_startle_reflex3.04219440
10MP0002272_abnormal_nervous_system3.01645742
11MP0002734_abnormal_mechanical_nocicepti2.81948324
12MP0001968_abnormal_touch/_nociception2.77585032
13MP0002572_abnormal_emotion/affect_behav2.76889685
14MP0009046_muscle_twitch2.75989958
15MP0003329_amyloid_beta_deposits2.64401724
16MP0008569_lethality_at_weaning2.46468587
17MP0001501_abnormal_sleep_pattern2.25657018
18MP0003879_abnormal_hair_cell2.22041026
19MP0003690_abnormal_glial_cell2.19467155
20MP0002735_abnormal_chemical_nociception2.18109804
21MP0002736_abnormal_nociception_after2.03945898
22MP0000920_abnormal_myelination2.02663083
23MP0001970_abnormal_pain_threshold1.93505080
24MP0004885_abnormal_endolymph1.87750449
25MP0002733_abnormal_thermal_nociception1.77838218
26MP0005646_abnormal_pituitary_gland1.76003552
27MP0003633_abnormal_nervous_system1.75320963
28MP0002067_abnormal_sensory_capabilities1.71234642
29MP0009780_abnormal_chondrocyte_physiolo1.69946259
30MP0006276_abnormal_autonomic_nervous1.69033652
31MP0000778_abnormal_nervous_system1.67558622
32MP0004811_abnormal_neuron_physiology1.66519562
33MP0002557_abnormal_social/conspecific_i1.61535951
34MP0001440_abnormal_grooming_behavior1.57421179
35MP0001502_abnormal_circadian_rhythm1.54717738
36MP0003787_abnormal_imprinting1.52892933
37MP0001905_abnormal_dopamine_level1.51569232
38MP0002066_abnormal_motor_capabilities/c1.50667624
39MP0002882_abnormal_neuron_morphology1.49259624
40MP0003631_nervous_system_phenotype1.48286230
41MP0001984_abnormal_olfaction1.47774230
42MP0000955_abnormal_spinal_cord1.45944238
43MP0005386_behavior/neurological_phenoty1.36384757
44MP0004924_abnormal_behavior1.36384757
45MP0003634_abnormal_glial_cell1.35062740
46MP0002822_catalepsy1.29013994
47MP0000604_amyloidosis1.27958953
48MP0001177_atelectasis1.27691398
49MP0001529_abnormal_vocalization1.19399980
50MP0002229_neurodegeneration1.18047658
51MP0003632_abnormal_nervous_system1.17420263
52MP0004742_abnormal_vestibular_system1.13657966
53MP0004130_abnormal_muscle_cell1.12298162
54MP0002184_abnormal_innervation1.11898599
55MP0002152_abnormal_brain_morphology1.07963371
56MP0005551_abnormal_eye_electrophysiolog1.02870460
57MP0001963_abnormal_hearing_physiology1.02571555
58MP0005645_abnormal_hypothalamus_physiol1.01745966
59MP0003122_maternal_imprinting0.99433315
60MP0003123_paternal_imprinting0.98613919
61MP0001485_abnormal_pinna_reflex0.97465853
62MP0003075_altered_response_to0.96874619
63MP0002638_abnormal_pupillary_reflex0.96309262
64MP0001346_abnormal_lacrimal_gland0.96123288
65MP0005167_abnormal_blood-brain_barrier0.94132614
66MP0002909_abnormal_adrenal_gland0.83296111
67MP0001986_abnormal_taste_sensitivity0.80955714
68MP0008874_decreased_physiological_sensi0.80877401
69MP0004142_abnormal_muscle_tone0.80443381
70MP0010386_abnormal_urinary_bladder0.78858165
71MP0008961_abnormal_basal_metabolism0.78245187
72MP0005084_abnormal_gallbladder_morpholo0.73697928
73MP0004147_increased_porphyrin_level0.71938113
74MP0002069_abnormal_eating/drinking_beha0.71705347
75MP0002752_abnormal_somatic_nervous0.71486497
76MP0005535_abnormal_body_temperature0.64896016
77MP0005623_abnormal_meninges_morphology0.59631431
78MP0000026_abnormal_inner_ear0.58376545
79MP0000569_abnormal_digit_pigmentation0.54835830
80MP0008872_abnormal_physiological_respon0.54671342
81MP0002653_abnormal_ependyma_morphology0.54365555
82MP0010769_abnormal_survival0.53679994
83MP0000579_abnormal_nail_morphology0.53674845
84MP0005253_abnormal_eye_physiology0.53147152
85MP0001943_abnormal_respiration0.50761765
86MP0003137_abnormal_impulse_conducting0.50469356
87MP0010768_mortality/aging0.49846548
88MP0001299_abnormal_eye_distance/0.49777968
89MP0010770_preweaning_lethality0.49700880
90MP0002082_postnatal_lethality0.49700880
91MP0003956_abnormal_body_size0.48899775
92MP0001348_abnormal_lacrimal_gland0.47315956
93MP0003121_genomic_imprinting0.45931272
94MP0003861_abnormal_nervous_system0.45774446
95MP0000631_abnormal_neuroendocrine_gland0.44670730
96MP0003172_abnormal_lysosome_physiology0.44567132
97MP0005171_absent_coat_pigmentation0.44536594
98MP0000566_synostosis0.44228269
99MP0005166_decreased_susceptibility_to0.42826866
100MP0000639_abnormal_adrenal_gland0.40242362

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.00565465
2Focal motor seizures (HP:0011153)7.48737422
3Focal seizures (HP:0007359)6.11424570
4Febrile seizures (HP:0002373)5.41738588
5Action tremor (HP:0002345)5.37258230
6Atonic seizures (HP:0010819)5.21323706
7Diplopia (HP:0000651)4.98158173
8Abnormality of binocular vision (HP:0011514)4.98158173
9Epileptic encephalopathy (HP:0200134)4.97676807
10Supranuclear gaze palsy (HP:0000605)4.79649495
11Ankle clonus (HP:0011448)4.56328377
12Neurofibrillary tangles (HP:0002185)4.46919780
13Generalized tonic-clonic seizures (HP:0002069)4.10878304
14Spastic gait (HP:0002064)3.89122093
15Abnormal eating behavior (HP:0100738)3.81213763
16Absence seizures (HP:0002121)3.74964797
17Papilledema (HP:0001085)3.73325809
18Visual hallucinations (HP:0002367)3.64062931
19Torticollis (HP:0000473)3.56043262
20Postural instability (HP:0002172)3.53158309
21Truncal ataxia (HP:0002078)3.53093367
22Dialeptic seizures (HP:0011146)3.52621291
23Cerebral inclusion bodies (HP:0100314)3.51257433
24Progressive cerebellar ataxia (HP:0002073)3.37943831
25Dysmetria (HP:0001310)3.37437810
26Hemiplegia (HP:0002301)3.36437876
27Intention tremor (HP:0002080)3.34829310
28Urinary bladder sphincter dysfunction (HP:0002839)3.29666364
29Cerebral hypomyelination (HP:0006808)3.27475485
30Limb dystonia (HP:0002451)3.25956330
31Mutism (HP:0002300)3.19218754
32Peripheral hypomyelination (HP:0007182)3.16993181
33Obstructive sleep apnea (HP:0002870)3.11828906
34Impaired vibration sensation in the lower limbs (HP:0002166)3.11333009
35Annular pancreas (HP:0001734)3.04701059
36Urinary urgency (HP:0000012)3.03127230
37Abnormality of the corticospinal tract (HP:0002492)3.02643943
38Focal dystonia (HP:0004373)2.93823912
39Depression (HP:0000716)2.85659078
40Tetraplegia (HP:0002445)2.85331628
41Lower limb muscle weakness (HP:0007340)2.85135925
42Scanning speech (HP:0002168)2.85082179
43Akinesia (HP:0002304)2.83196877
44Delusions (HP:0000746)2.80454480
45Neuronal loss in central nervous system (HP:0002529)2.79740104
46Status epilepticus (HP:0002133)2.78659642
47Craniofacial dystonia (HP:0012179)2.73952439
48Degeneration of the lateral corticospinal tracts (HP:0002314)2.73180697
49Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.73180697
50Hemiparesis (HP:0001269)2.71473012
51Increased circulating renin level (HP:0000848)2.70118763
52Bradykinesia (HP:0002067)2.68565608
53Dysdiadochokinesis (HP:0002075)2.67439647
54Anxiety (HP:0000739)2.67066375
55Epileptiform EEG discharges (HP:0011182)2.66727032
56Split foot (HP:0001839)2.56685899
57Clonus (HP:0002169)2.56008544
58Megalencephaly (HP:0001355)2.53626574
59Amblyopia (HP:0000646)2.49877865
60Apathy (HP:0000741)2.48704720
61Insomnia (HP:0100785)2.44650342
62Poor eye contact (HP:0000817)2.44393448
63Spastic tetraparesis (HP:0001285)2.41822123
64Rigidity (HP:0002063)2.33980779
65Sleep apnea (HP:0010535)2.33171916
66EEG with generalized epileptiform discharges (HP:0011198)2.28348192
67Drooling (HP:0002307)2.21957625
68Polyphagia (HP:0002591)2.21883319
69Diminished motivation (HP:0000745)2.21716554
70Choreoathetosis (HP:0001266)2.15691292
71Morphological abnormality of the pyramidal tract (HP:0002062)2.14563440
72Impaired vibratory sensation (HP:0002495)2.14370637
73Rapidly progressive (HP:0003678)2.13512148
74Abnormality of the lower motor neuron (HP:0002366)2.11515219
75Hypsarrhythmia (HP:0002521)2.10772498
76Excessive salivation (HP:0003781)2.06439907
77Abnormal social behavior (HP:0012433)2.03918578
78Impaired social interactions (HP:0000735)2.03918578
79Incomplete penetrance (HP:0003829)2.02287875
80Impaired smooth pursuit (HP:0007772)2.01804671
81CNS hypomyelination (HP:0003429)1.99849815
82Stereotypic behavior (HP:0000733)1.96338913
83Bundle branch block (HP:0011710)1.95708446
84Broad-based gait (HP:0002136)1.94272418
85Aplasia involving bones of the upper limbs (HP:0009823)1.86594238
86Aplasia of the phalanges of the hand (HP:0009802)1.86594238
87Aplasia involving bones of the extremities (HP:0009825)1.86594238
88Overgrowth (HP:0001548)1.84670099
89Hyperventilation (HP:0002883)1.82856944
90Abnormality of ocular smooth pursuit (HP:0000617)1.82411146
91Fetal akinesia sequence (HP:0001989)1.81094831
92Gaze-evoked nystagmus (HP:0000640)1.78568137
93Ventricular fibrillation (HP:0001663)1.78397700
94Amyotrophic lateral sclerosis (HP:0007354)1.76830349
95Memory impairment (HP:0002354)1.74942784
96Dementia (HP:0000726)1.72737790
97Abnormality of calcium-phosphate metabolism (HP:0100530)1.70594192
98Alacrima (HP:0000522)1.70131521
99Lower limb asymmetry (HP:0100559)1.69493020
100Heart block (HP:0012722)1.68510400

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.71469896
2NTRK24.56012377
3NTRK34.14034327
4PAK63.91096650
5MARK13.65043809
6DAPK23.37227059
7UHMK12.84915949
8PRKD32.27429265
9MINK12.22280520
10CAMKK12.20494769
11MAP3K92.18936131
12NTRK12.17380690
13RIPK41.92081709
14CASK1.80415604
15PINK11.76792153
16PLK21.67546227
17LATS21.53996622
18CDK51.53932774
19ARAF1.52283717
20GRK51.50863588
21CAMK2B1.40288455
22TYRO31.37473118
23CAMK11.35525254
24PHKG11.33747487
25PHKG21.33747487
26CDK191.32604729
27KSR21.31516960
28MAPK131.27381546
29DAPK11.25318967
30SGK4941.23546534
31SGK2231.23546534
32PRKCG1.21460038
33NEK61.20345582
34BMPR21.14871284
35CDK151.09696991
36CAMK2A1.09106763
37PRKCH1.06685262
38RIPK11.06577981
39CDK181.05984794
40SIK21.05780462
41PKN11.05764951
42CAMK2G1.05011809
43PAK31.01528003
44CDK11A0.99806445
45PRPF4B0.99301388
46CDK140.98133517
47DYRK1A0.97815056
48CAMKK20.94274708
49SGK20.89697453
50MARK20.89481083
51MAPK120.84123560
52STK380.83933298
53ALK0.83435753
54ROCK20.78462742
55SGK10.77772944
56MAP3K130.74242950
57OXSR10.72791144
58STK110.72318858
59SGK30.71955272
60CAMK2D0.68621601
61MAPK100.67940471
62CAMK40.66447683
63MAP3K40.65551866
64TNK20.63397689
65BRSK10.63220528
66FES0.62943378
67LIMK10.61455858
68PDK10.60358349
69DAPK30.59852165
70KSR10.59612464
71RPS6KA30.58407811
72FGFR20.53745796
73MAP2K70.52295490
74PDPK10.51477932
75ROCK10.49499710
76MAP2K40.48999942
77FYN0.48142585
78RAF10.47075610
79PRKCZ0.47054233
80LMTK20.45430965
81CCNB10.43643026
82MAP3K110.43365628
83CSNK1G20.41173677
84BRAF0.39534685
85PRKCA0.37018058
86RET0.36556830
87ERBB20.36153037
88PRKG20.33310495
89SRC0.31620263
90TESK10.31035914
91PRKG10.29916863
92PRKACA0.29601076
93WNK10.29592243
94MAP3K10.29132835
95MAP3K20.28970115
96PRKCB0.28535952
97CSNK1D0.27213620
98MAPKAPK50.26042681
99PRKCE0.25718388
100JAK20.25413146

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.92424815
2Nicotine addiction_Homo sapiens_hsa050333.87226881
3GABAergic synapse_Homo sapiens_hsa047272.89718511
4Circadian entrainment_Homo sapiens_hsa047132.84749093
5Amphetamine addiction_Homo sapiens_hsa050312.73908171
6Glutamatergic synapse_Homo sapiens_hsa047242.70916085
7Morphine addiction_Homo sapiens_hsa050322.68838308
8Long-term potentiation_Homo sapiens_hsa047202.65550007
9Insulin secretion_Homo sapiens_hsa049112.60371870
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.56036645
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.44865746
12Gastric acid secretion_Homo sapiens_hsa049712.35726713
13Cocaine addiction_Homo sapiens_hsa050302.08592094
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.06986248
15Dopaminergic synapse_Homo sapiens_hsa047282.03834894
16Salivary secretion_Homo sapiens_hsa049702.01747475
17Aldosterone synthesis and secretion_Homo sapiens_hsa049252.01611930
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.94287741
19Cholinergic synapse_Homo sapiens_hsa047251.85341674
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.79844593
21Olfactory transduction_Homo sapiens_hsa047401.75798758
22Oxytocin signaling pathway_Homo sapiens_hsa049211.65396359
23Calcium signaling pathway_Homo sapiens_hsa040201.58274997
24Taste transduction_Homo sapiens_hsa047421.46734665
25cAMP signaling pathway_Homo sapiens_hsa040241.44162415
26Vitamin B6 metabolism_Homo sapiens_hsa007501.41229717
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40210909
28Renin secretion_Homo sapiens_hsa049241.39859300
29Collecting duct acid secretion_Homo sapiens_hsa049661.34376055
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32022874
31GnRH signaling pathway_Homo sapiens_hsa049121.28107080
32Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.27871141
33Bile secretion_Homo sapiens_hsa049761.27030164
34Estrogen signaling pathway_Homo sapiens_hsa049151.24549518
35Gap junction_Homo sapiens_hsa045401.23964055
36Pancreatic secretion_Homo sapiens_hsa049721.23751255
37Serotonergic synapse_Homo sapiens_hsa047261.13620735
38Melanogenesis_Homo sapiens_hsa049161.13346540
39Thyroid hormone synthesis_Homo sapiens_hsa049181.09671564
40Long-term depression_Homo sapiens_hsa047301.07896964
41Vibrio cholerae infection_Homo sapiens_hsa051101.05009149
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02813901
43Glioma_Homo sapiens_hsa052141.02258381
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02226877
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00594369
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98623264
47Phospholipase D signaling pathway_Homo sapiens_hsa040720.92837943
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.92005041
49Oocyte meiosis_Homo sapiens_hsa041140.87257172
50Prion diseases_Homo sapiens_hsa050200.86270293
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84354222
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78409653
53Axon guidance_Homo sapiens_hsa043600.75607596
54ErbB signaling pathway_Homo sapiens_hsa040120.75543165
55Cardiac muscle contraction_Homo sapiens_hsa042600.75453746
56Dilated cardiomyopathy_Homo sapiens_hsa054140.72056958
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71437661
58Histidine metabolism_Homo sapiens_hsa003400.69672848
59Circadian rhythm_Homo sapiens_hsa047100.64295618
60Rap1 signaling pathway_Homo sapiens_hsa040150.63821726
61Ras signaling pathway_Homo sapiens_hsa040140.61223507
62Dorso-ventral axis formation_Homo sapiens_hsa043200.60346147
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59797880
64Ovarian steroidogenesis_Homo sapiens_hsa049130.59598443
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59333834
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.56355286
67Phototransduction_Homo sapiens_hsa047440.55407330
68Arginine and proline metabolism_Homo sapiens_hsa003300.54583458
69Type II diabetes mellitus_Homo sapiens_hsa049300.54019223
70Inositol phosphate metabolism_Homo sapiens_hsa005620.53656077
71MAPK signaling pathway_Homo sapiens_hsa040100.52988157
72Glucagon signaling pathway_Homo sapiens_hsa049220.52660103
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51926723
74VEGF signaling pathway_Homo sapiens_hsa043700.49502980
75beta-Alanine metabolism_Homo sapiens_hsa004100.47351005
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46619839
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44845659
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44616354
79Alcoholism_Homo sapiens_hsa050340.43114487
80Arginine biosynthesis_Homo sapiens_hsa002200.42442356
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.41443419
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38711454
83Endocytosis_Homo sapiens_hsa041440.38110022
84Choline metabolism in cancer_Homo sapiens_hsa052310.37151546
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36837403
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.30454368
87Mineral absorption_Homo sapiens_hsa049780.26545574
88Wnt signaling pathway_Homo sapiens_hsa043100.24796684
89Insulin signaling pathway_Homo sapiens_hsa049100.22507138
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.21304249
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.21207658
92Alzheimers disease_Homo sapiens_hsa050100.19912919
93AMPK signaling pathway_Homo sapiens_hsa041520.18787407
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.18311815
95Tight junction_Homo sapiens_hsa045300.17503356
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.17420956
97Fatty acid biosynthesis_Homo sapiens_hsa000610.16847986
98Hippo signaling pathway_Homo sapiens_hsa043900.16406137
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.13664166
100mTOR signaling pathway_Homo sapiens_hsa041500.13458845

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