C8ORF44-SGK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring read-through transcription between the neighboring putative uncharacterized protein C8orf44 (GeneID 56260) and serine/threonine-protein kinase Sgk3 (GeneID 23678) genes on chromosome 8. The read-through transcript produces a protein that shares sequence identity with the downstream gene product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)6.94320257
2cell wall macromolecule metabolic process (GO:0044036)6.37267998
3regulation of cilium movement (GO:0003352)4.88778004
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.87273295
5establishment of protein localization to mitochondrial membrane (GO:0090151)4.24595972
6ATP synthesis coupled proton transport (GO:0015986)4.13185134
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.13185134
8histone H2A acetylation (GO:0043968)3.97774895
9protein complex biogenesis (GO:0070271)3.86607674
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.82195238
11mitochondrial respiratory chain complex assembly (GO:0033108)3.67299855
12proteasome assembly (GO:0043248)3.64011777
13protein neddylation (GO:0045116)3.59583920
14GPI anchor metabolic process (GO:0006505)3.55661733
15respiratory chain complex IV assembly (GO:0008535)3.52492961
16mitochondrial respiratory chain complex I assembly (GO:0032981)3.45334053
17NADH dehydrogenase complex assembly (GO:0010257)3.45334053
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.45334053
19respiratory electron transport chain (GO:0022904)3.45172032
20rRNA modification (GO:0000154)3.44255097
21electron transport chain (GO:0022900)3.42755024
22mannosylation (GO:0097502)3.42589693
23positive regulation of histone H3-K4 methylation (GO:0051571)3.41928836
24preassembly of GPI anchor in ER membrane (GO:0016254)3.36298306
25adenosine metabolic process (GO:0046085)3.34422861
26exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.29124957
27GPI anchor biosynthetic process (GO:0006506)3.26697325
28nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.20932028
29detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.18724039
30indolalkylamine metabolic process (GO:0006586)3.17507542
31myelin assembly (GO:0032288)3.07243050
32cytochrome complex assembly (GO:0017004)3.05849485
33regulation of MHC class II biosynthetic process (GO:0045346)3.05143866
34peptidyl-histidine modification (GO:0018202)3.04249927
35nonmotile primary cilium assembly (GO:0035058)2.98434221
36rRNA methylation (GO:0031167)2.94825377
37regulation of glucokinase activity (GO:0033131)2.94741249
38regulation of hexokinase activity (GO:1903299)2.94741249
39platelet dense granule organization (GO:0060155)2.94634756
40negative regulation of appetite (GO:0032099)2.93970776
41negative regulation of response to food (GO:0032096)2.93970776
42tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.92804891
43RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.92804891
44cellular response to leptin stimulus (GO:0044320)2.92224109
45retinal rod cell development (GO:0046548)2.90311695
46chaperone-mediated protein transport (GO:0072321)2.89719499
47ubiquinone biosynthetic process (GO:0006744)2.89408269
48piRNA metabolic process (GO:0034587)2.88574544
49branched-chain amino acid catabolic process (GO:0009083)2.86942193
50negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.86295769
51ribosomal large subunit biogenesis (GO:0042273)2.85346646
52deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.79683556
53organelle membrane fusion (GO:0090174)2.78850489
54intracellular protein transmembrane import (GO:0044743)2.77294348
55base-excision repair, AP site formation (GO:0006285)2.76742569
56pyrimidine nucleotide catabolic process (GO:0006244)2.76313257
57deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.76162324
58DNA double-strand break processing (GO:0000729)2.75720532
59metallo-sulfur cluster assembly (GO:0031163)2.75225078
60iron-sulfur cluster assembly (GO:0016226)2.75225078
61ribosome assembly (GO:0042255)2.75152493
62photoreceptor cell maintenance (GO:0045494)2.73315416
63cullin deneddylation (GO:0010388)2.72875492
64regulation of mitotic spindle checkpoint (GO:1903504)2.72699009
65regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.72699009
66ubiquinone metabolic process (GO:0006743)2.72539826
67regulation of microtubule-based movement (GO:0060632)2.72381053
68ribosomal small subunit assembly (GO:0000028)2.70637588
69purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.68102877
70hydrogen ion transmembrane transport (GO:1902600)2.67710240
71purine deoxyribonucleotide metabolic process (GO:0009151)2.67623461
72cilium morphogenesis (GO:0060271)2.67414230
73protein-cofactor linkage (GO:0018065)2.67000729
74DNA deamination (GO:0045006)2.65017681
75hydrogen transport (GO:0006818)2.64569149
76proton transport (GO:0015992)2.63367783
77L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.62651961
78response to leptin (GO:0044321)2.61791599
79autophagic vacuole fusion (GO:0000046)2.60347324
80protein deneddylation (GO:0000338)2.60113971
81termination of RNA polymerase III transcription (GO:0006386)2.59028886
82transcription elongation from RNA polymerase III promoter (GO:0006385)2.59028886
83quinone biosynthetic process (GO:1901663)2.57673173
84positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.56878532
85striatum development (GO:0021756)2.56744993
86RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.55154264
87inositol phosphate catabolic process (GO:0071545)2.54745115
88purine nucleotide salvage (GO:0032261)2.54695606
89brain morphogenesis (GO:0048854)2.54070708
90heart contraction (GO:0060047)2.51804153
91heart process (GO:0003015)2.51804153
92C-terminal protein lipidation (GO:0006501)2.50577662
93regulation of helicase activity (GO:0051095)2.49542820
94negative regulation of telomere maintenance (GO:0032205)2.49143707
95phosphorylated carbohydrate dephosphorylation (GO:0046838)2.48315243
96inositol phosphate dephosphorylation (GO:0046855)2.48315243
97water-soluble vitamin biosynthetic process (GO:0042364)2.48184938
98organelle disassembly (GO:1903008)2.47224360
99intraciliary transport (GO:0042073)2.45020337
100C-terminal protein amino acid modification (GO:0018410)2.44983604

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.49183892
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.44256545
3ZNF274_21170338_ChIP-Seq_K562_Hela3.37764275
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.12745970
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.07641468
6VDR_22108803_ChIP-Seq_LS180_Human2.95623454
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.88351683
8IGF1R_20145208_ChIP-Seq_DFB_Human2.86022771
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.70798717
10ELK1_19687146_ChIP-ChIP_HELA_Human2.64185614
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.62701425
12VDR_23849224_ChIP-Seq_CD4+_Human2.49890423
13FUS_26573619_Chip-Seq_HEK293_Human2.49646511
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.47274008
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.46962934
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.26924826
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.16501092
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.10645951
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08625414
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.05665687
21EWS_26573619_Chip-Seq_HEK293_Human2.02745576
22FOXP3_21729870_ChIP-Seq_TREG_Human1.95784644
23TAF15_26573619_Chip-Seq_HEK293_Human1.83848319
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.78243807
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.76496026
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75531901
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74047433
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.72803613
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.72676370
30GATA1_22025678_ChIP-Seq_K562_Human1.71962946
31MYC_18940864_ChIP-ChIP_HL60_Human1.68409175
32GBX2_23144817_ChIP-Seq_PC3_Human1.67792152
33MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.62967066
34P300_19829295_ChIP-Seq_ESCs_Human1.59603551
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57723724
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.57130016
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56180126
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.53784866
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52253951
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50194043
41ER_23166858_ChIP-Seq_MCF-7_Human1.48601811
42IRF8_22096565_ChIP-ChIP_GC-B_Human1.47658618
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45788499
44EGR1_23403033_ChIP-Seq_LIVER_Mouse1.44942674
45TP53_22573176_ChIP-Seq_HFKS_Human1.44593415
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.40460387
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40442939
48CBP_20019798_ChIP-Seq_JUKART_Human1.38326894
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38326894
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37984294
51NANOG_19829295_ChIP-Seq_ESCs_Human1.33847207
52SOX2_19829295_ChIP-Seq_ESCs_Human1.33847207
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.33316604
54CRX_20693478_ChIP-Seq_RETINA_Mouse1.31874452
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30349276
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27931037
57IRF1_19129219_ChIP-ChIP_H3396_Human1.27753748
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.26954574
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26954574
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.26797963
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23240239
62AR_20517297_ChIP-Seq_VCAP_Human1.20480629
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20399073
64E2F7_22180533_ChIP-Seq_HELA_Human1.15997326
65AR_25329375_ChIP-Seq_VCAP_Human1.13516165
66TCF4_22108803_ChIP-Seq_LS180_Human1.12957406
67E2F4_17652178_ChIP-ChIP_JURKAT_Human1.12873905
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12640219
69FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10310481
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.10182531
71STAT3_18555785_Chip-Seq_ESCs_Mouse1.09780197
72CDX2_22108803_ChIP-Seq_LS180_Human1.07962058
73OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07457399
74EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07371171
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06385417
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05698984
77CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04620976
78SMAD4_21799915_ChIP-Seq_A2780_Human1.04399350
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.03988461
80GATA3_26560356_Chip-Seq_TH2_Human1.03380738
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03322920
82GABP_19822575_ChIP-Seq_HepG2_Human1.02912097
83HTT_18923047_ChIP-ChIP_STHdh_Human1.02616603
84SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01748946
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01616345
86NCOR_22424771_ChIP-Seq_293T_Human1.00952976
87P53_22387025_ChIP-Seq_ESCs_Mouse1.00911317
88P300_18555785_Chip-Seq_ESCs_Mouse1.00410118
89MYC_18555785_ChIP-Seq_MESCs_Mouse0.99401962
90GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96230093
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95084576
92FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94889793
93RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94481226
94SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94423034
95CMYC_18555785_Chip-Seq_ESCs_Mouse0.93842905
96ELK1_22589737_ChIP-Seq_MCF10A_Human0.92951504
97BCAT_22108803_ChIP-Seq_LS180_Human0.92786193
98SOX2_18555785_Chip-Seq_ESCs_Mouse0.92253723
99PRDM14_20953172_ChIP-Seq_ESCs_Human0.92201257
100TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.91723124

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level3.67397183
2MP0003880_abnormal_central_pattern3.42836639
3MP0003806_abnormal_nucleotide_metabolis3.06555004
4MP0002837_dystrophic_cardiac_calcinosis2.91766022
5MP0006292_abnormal_olfactory_placode2.64482900
6MP0006072_abnormal_retinal_apoptosis2.57557774
7MP0008058_abnormal_DNA_repair2.49154537
8MP0003195_calcinosis2.48629330
9MP0010386_abnormal_urinary_bladder2.44272024
10MP0005551_abnormal_eye_electrophysiolog2.37400172
11MP0008877_abnormal_DNA_methylation2.33141570
12MP0001984_abnormal_olfaction2.22270233
13MP0003011_delayed_dark_adaptation2.12726241
14MP0000569_abnormal_digit_pigmentation2.03201946
15MP0008789_abnormal_olfactory_epithelium1.91365444
16MP0009697_abnormal_copulation1.88716353
17MP0003718_maternal_effect1.85812574
18MP0005646_abnormal_pituitary_gland1.82742462
19MP0009379_abnormal_foot_pigmentation1.71880618
20MP0003787_abnormal_imprinting1.71224547
21MP0002938_white_spotting1.70909277
22MP0006276_abnormal_autonomic_nervous1.70481232
23MP0001764_abnormal_homeostasis1.65232601
24MP0005253_abnormal_eye_physiology1.64971160
25MP0005084_abnormal_gallbladder_morpholo1.64678420
26MP0002876_abnormal_thyroid_physiology1.62358933
27MP0001529_abnormal_vocalization1.57456669
28MP0005645_abnormal_hypothalamus_physiol1.56004823
29MP0006036_abnormal_mitochondrial_physio1.55301869
30MP0001905_abnormal_dopamine_level1.52379614
31MP0005332_abnormal_amino_acid1.49181218
32MP0006035_abnormal_mitochondrial_morpho1.48840693
33MP0005075_abnormal_melanosome_morpholog1.48312972
34MP0005174_abnormal_tail_pigmentation1.47563763
35MP0002735_abnormal_chemical_nociception1.39375730
36MP0005397_hematopoietic_system_phenotyp1.36147838
37MP0001545_abnormal_hematopoietic_system1.36147838
38MP0002736_abnormal_nociception_after1.35910360
39MP0000372_irregular_coat_pigmentation1.35793316
40MP0010094_abnormal_chromosome_stability1.35459280
41MP0001968_abnormal_touch/_nociception1.35299845
42MP0005394_taste/olfaction_phenotype1.32924161
43MP0005499_abnormal_olfactory_system1.32924161
44MP0003186_abnormal_redox_activity1.30713253
45MP0004215_abnormal_myocardial_fiber1.21712829
46MP0000631_abnormal_neuroendocrine_gland1.21358491
47MP0001835_abnormal_antigen_presentation1.20329498
48MP0004142_abnormal_muscle_tone1.19036570
49MP0002909_abnormal_adrenal_gland1.18418551
50MP0005636_abnormal_mineral_homeostasis1.16553766
51MP0002272_abnormal_nervous_system1.15402149
52MP0002638_abnormal_pupillary_reflex1.12315885
53MP0002277_abnormal_respiratory_mucosa1.09057959
54MP0005410_abnormal_fertilization1.06795555
55MP0000516_abnormal_urinary_system1.06558660
56MP0005367_renal/urinary_system_phenotyp1.06558660
57MP0004133_heterotaxia1.05215355
58MP0001970_abnormal_pain_threshold1.04605658
59MP0002229_neurodegeneration1.04603281
60MP0005386_behavior/neurological_phenoty1.04586225
61MP0004924_abnormal_behavior1.04586225
62MP0004043_abnormal_pH_regulation1.04509328
63MP0000427_abnormal_hair_cycle1.03161359
64MP0003786_premature_aging1.02590362
65MP0000639_abnormal_adrenal_gland1.01969252
66MP0010329_abnormal_lipoprotein_level1.01353545
67MP0008875_abnormal_xenobiotic_pharmacok0.99978968
68MP0009046_muscle_twitch0.99893719
69MP0005379_endocrine/exocrine_gland_phen0.99613453
70MP0001756_abnormal_urination0.99181918
71MP0003136_yellow_coat_color0.98503704
72MP0000358_abnormal_cell_content/0.98075629
73MP0000013_abnormal_adipose_tissue0.96489720
74MP0001188_hyperpigmentation0.96413036
75MP0000230_abnormal_systemic_arterial0.94168227
76MP0009745_abnormal_behavioral_response0.93959282
77MP0004145_abnormal_muscle_electrophysio0.91218224
78MP0008872_abnormal_physiological_respon0.91054927
79MP0002557_abnormal_social/conspecific_i0.90763877
80MP0001501_abnormal_sleep_pattern0.89655270
81MP0002572_abnormal_emotion/affect_behav0.89321565
82MP0001929_abnormal_gametogenesis0.89213775
83MP0002693_abnormal_pancreas_physiology0.88701368
84MP0003698_abnormal_male_reproductive0.87683975
85MP0001324_abnormal_eye_pigmentation0.85844327
86MP0001485_abnormal_pinna_reflex0.85544541
87MP0002822_catalepsy0.84890592
88MP0002095_abnormal_skin_pigmentation0.84884360
89MP0003567_abnormal_fetal_cardiomyocyte0.83754339
90MP0000538_abnormal_urinary_bladder0.83291122
91MP0002733_abnormal_thermal_nociception0.82880791
92MP0005319_abnormal_enzyme/_coenzyme0.82795865
93MP0003137_abnormal_impulse_conducting0.82602623
94MP0005310_abnormal_salivary_gland0.76930687
95MP0001486_abnormal_startle_reflex0.76582892
96MP0002067_abnormal_sensory_capabilities0.76568007
97MP0001944_abnormal_pancreas_morphology0.76212292
98MP0002102_abnormal_ear_morphology0.74876997
99MP0005535_abnormal_body_temperature0.74403598
100MP0000653_abnormal_sex_gland0.72937661

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.62935300
2Increased hepatocellular lipid droplets (HP:0006565)3.60194131
3Hepatic necrosis (HP:0002605)3.54888033
4Mitochondrial inheritance (HP:0001427)3.53602126
5Hepatocellular necrosis (HP:0001404)3.47837773
6Lipid accumulation in hepatocytes (HP:0006561)3.44731082
7Molar tooth sign on MRI (HP:0002419)3.40834719
8Abnormality of midbrain morphology (HP:0002418)3.40834719
9Methylmalonic acidemia (HP:0002912)3.39548820
10Increased CSF lactate (HP:0002490)3.39246414
11Pancreatic cysts (HP:0001737)3.35256003
12Short tibia (HP:0005736)3.29459341
13Progressive macrocephaly (HP:0004481)3.28282859
14Acute encephalopathy (HP:0006846)3.24019887
153-Methylglutaconic aciduria (HP:0003535)3.20842011
16Abnormal mitochondria in muscle tissue (HP:0008316)3.18005813
17Aplasia/Hypoplasia of the tibia (HP:0005772)3.14891507
18Methylmalonic aciduria (HP:0012120)3.10571254
19Generalized aminoaciduria (HP:0002909)3.07493380
20Pancreatic fibrosis (HP:0100732)2.97759757
21Medial flaring of the eyebrow (HP:0010747)2.95660180
22Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.88171887
23Abnormality of alanine metabolism (HP:0010916)2.88171887
24Hyperalaninemia (HP:0003348)2.88171887
25Hypokinesia (HP:0002375)2.87303037
26Hypothermia (HP:0002045)2.85338877
27Aplastic anemia (HP:0001915)2.79664856
28Renal Fanconi syndrome (HP:0001994)2.79492423
29True hermaphroditism (HP:0010459)2.75002636
30Nephronophthisis (HP:0000090)2.74963775
31Decreased activity of mitochondrial respiratory chain (HP:0008972)2.63891884
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.63891884
33Median cleft lip (HP:0000161)2.62854565
34Abnormality of vitamin B metabolism (HP:0004340)2.62842836
35Increased intramyocellular lipid droplets (HP:0012240)2.62638403
36Congenital primary aphakia (HP:0007707)2.60365392
37Increased serum lactate (HP:0002151)2.57669460
38Gait imbalance (HP:0002141)2.56664291
39Type II lissencephaly (HP:0007260)2.52024565
40Cerebral edema (HP:0002181)2.47207110
41Lactic acidosis (HP:0003128)2.47094149
42Abnormality of aspartate family amino acid metabolism (HP:0010899)2.46322767
43Congenital stationary night blindness (HP:0007642)2.45264592
44Renal cortical cysts (HP:0000803)2.44783920
45Abnormality of dicarboxylic acid metabolism (HP:0010995)2.44158810
46Dicarboxylic aciduria (HP:0003215)2.44158810
47Abnormality of the vitamin B12 metabolism (HP:0004341)2.41717993
48Glycosuria (HP:0003076)2.40602106
49Abnormality of urine glucose concentration (HP:0011016)2.40602106
50Abnormality of the renal cortex (HP:0011035)2.40038374
51Optic disc pallor (HP:0000543)2.38003092
52Nephrogenic diabetes insipidus (HP:0009806)2.34458227
53Abnormality of methionine metabolism (HP:0010901)2.32724727
54Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.25141713
55Exercise-induced muscle cramps (HP:0003710)2.24093997
56Exertional dyspnea (HP:0002875)2.23754694
57Increased muscle lipid content (HP:0009058)2.22551116
58Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.19043347
59Attenuation of retinal blood vessels (HP:0007843)2.17273751
60Type I transferrin isoform profile (HP:0003642)2.16872226
61Absent rod-and cone-mediated responses on ERG (HP:0007688)2.16759506
62Abnormality of serum amino acid levels (HP:0003112)2.15813476
63Congenital, generalized hypertrichosis (HP:0004540)2.12564015
64Abnormality of the renal medulla (HP:0100957)2.10524838
65Respiratory failure (HP:0002878)2.07759912
66Microvesicular hepatic steatosis (HP:0001414)2.05574984
67Metaphyseal dysplasia (HP:0100255)2.05268598
68Increased serum pyruvate (HP:0003542)2.05164479
69Lethargy (HP:0001254)2.05036199
70Abnormality of renal resorption (HP:0011038)2.02900491
71Exercise intolerance (HP:0003546)2.01774414
72Genital tract atresia (HP:0001827)2.00597926
73Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.99665226
74Abnormal protein N-linked glycosylation (HP:0012347)1.99665226
75Abnormal protein glycosylation (HP:0012346)1.99665226
76Abnormal glycosylation (HP:0012345)1.99665226
77Respiratory difficulties (HP:0002880)1.99629123
78Constricted visual fields (HP:0001133)1.95879200
79Cerebellar dysplasia (HP:0007033)1.95420325
80Abolished electroretinogram (ERG) (HP:0000550)1.92365798
81Aplasia/Hypoplasia of the tongue (HP:0010295)1.90587343
82Abnormality of homocysteine metabolism (HP:0010919)1.88662774
83Homocystinuria (HP:0002156)1.88662774
84Hypoglycemic coma (HP:0001325)1.86100139
85Abnormal rod and cone electroretinograms (HP:0008323)1.82695622
86Aplasia/Hypoplasia of the uvula (HP:0010293)1.81938075
87Dynein arm defect of respiratory motile cilia (HP:0012255)1.81013168
88Absent/shortened dynein arms (HP:0200106)1.81013168
89Hyperphosphaturia (HP:0003109)1.79057521
90Decreased electroretinogram (ERG) amplitude (HP:0000654)1.77111624
91Poor coordination (HP:0002370)1.76946589
92Diminished movement (HP:0002374)1.75412057
93Hyperglycinemia (HP:0002154)1.74811203
94Retinal dysplasia (HP:0007973)1.74497768
95Vaginal atresia (HP:0000148)1.74155583
96Bifid tongue (HP:0010297)1.73881645
97Megaloblastic anemia (HP:0001889)1.71370456
98Abnormality of the anterior horn cell (HP:0006802)1.71280024
99Degeneration of anterior horn cells (HP:0002398)1.71280024
100Tubular atrophy (HP:0000092)1.69047215

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.91343219
2EIF2AK34.01656277
3FRK3.19867705
4TAOK32.88014565
5BCKDK2.75758801
6WNK32.55182089
7TRIM282.49780336
8NUAK12.03479791
9EPHA41.86380758
10ADRBK21.86024923
11ARAF1.83228218
12BMPR1B1.73091551
13ERBB31.68892929
14CDK81.55723455
15VRK21.54245631
16MUSK1.53640825
17MAP3K121.51292212
18PINK11.50633173
19CCNB11.47275103
20GRK11.43743728
21ZAK1.42115944
22PBK1.41814900
23VRK11.40127538
24CSNK1G31.37703973
25MAP3K91.31757904
26CSNK1G21.31234659
27MAP3K131.26417834
28MAPK131.26335876
29KIT1.22645547
30CSNK1G11.19083259
31FLT31.18792025
32BRSK21.12653803
33MKNK11.12312123
34OXSR11.11909091
35PLK41.08741161
36TLK11.07811763
37LIMK11.06542287
38PRKCE1.06336847
39TEC1.06187534
40WEE10.99097095
41PLK20.98575641
42BUB10.95443688
43CDK30.95276582
44STK390.94943473
45EIF2AK20.94564549
46NEK10.87132830
47CASK0.87090414
48MST40.86115850
49INSRR0.84690811
50CSNK1A1L0.83938563
51CDK190.82328466
52PAK30.80887725
53PLK30.79779182
54RPS6KA40.77661910
55PHKG20.77106931
56PHKG10.77106931
57WNK40.68497534
58CSF1R0.68191404
59CSNK1A10.68083094
60NTRK30.67994824
61RPS6KA50.66282810
62TXK0.65850008
63MKNK20.62002468
64RAF10.60788406
65DYRK20.59035857
66PRKCG0.58757119
67DAPK20.58615151
68BMPR20.58158043
69PDK20.56922180
70ACVR1B0.56551372
71TTK0.56364867
72SRPK10.53594578
73CSNK2A20.53300697
74BCR0.52064116
75EIF2AK10.51783324
76MOS0.51371520
77TNK20.50579789
78MYLK0.49871933
79TNIK0.48403480
80BRAF0.48123248
81PKN10.46806053
82PLK10.46603763
83PIM20.46169582
84KDR0.45857876
85ITK0.45403039
86CSNK2A10.44145394
87MAPKAPK50.42581008
88TESK20.42428377
89PRKACB0.42231482
90ATM0.40884674
91TGFBR10.40824331
92OBSCN0.40480216
93SYK0.39993601
94FGFR20.38905444
95ABL10.38454051
96ATR0.38005888
97STK38L0.37696336
98PRKACA0.37431489
99ADRBK10.37293495
100LYN0.34064467

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.95027087
2Oxidative phosphorylation_Homo sapiens_hsa001903.58987623
3Parkinsons disease_Homo sapiens_hsa050123.07527628
4Proteasome_Homo sapiens_hsa030502.99959959
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.65684259
6Homologous recombination_Homo sapiens_hsa034402.54263054
7Ribosome_Homo sapiens_hsa030102.20380453
8Sulfur metabolism_Homo sapiens_hsa009202.11153853
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.11096202
10Propanoate metabolism_Homo sapiens_hsa006402.10157303
11Huntingtons disease_Homo sapiens_hsa050161.99782743
12RNA polymerase_Homo sapiens_hsa030201.97754455
13Basal transcription factors_Homo sapiens_hsa030221.96479477
14Selenocompound metabolism_Homo sapiens_hsa004501.93364017
15Mismatch repair_Homo sapiens_hsa034301.91306521
16Alzheimers disease_Homo sapiens_hsa050101.89085491
17Phototransduction_Homo sapiens_hsa047441.88763924
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.77082935
19Butanoate metabolism_Homo sapiens_hsa006501.74110704
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73061233
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70112561
22RNA degradation_Homo sapiens_hsa030181.68039422
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.57009709
24Fanconi anemia pathway_Homo sapiens_hsa034601.51203956
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.48911257
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46220955
27Tryptophan metabolism_Homo sapiens_hsa003801.41764441
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.40350661
29Regulation of autophagy_Homo sapiens_hsa041401.35706746
30Nucleotide excision repair_Homo sapiens_hsa034201.33502811
31Asthma_Homo sapiens_hsa053101.32488859
32Non-homologous end-joining_Homo sapiens_hsa034501.31231870
33Cardiac muscle contraction_Homo sapiens_hsa042601.30278644
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.25574588
35Pyrimidine metabolism_Homo sapiens_hsa002401.21422725
36Steroid biosynthesis_Homo sapiens_hsa001001.19224554
37Purine metabolism_Homo sapiens_hsa002301.12969662
38Peroxisome_Homo sapiens_hsa041461.11552707
39Base excision repair_Homo sapiens_hsa034101.10896036
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.10689358
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07081651
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06540403
43DNA replication_Homo sapiens_hsa030301.05422805
44Fatty acid elongation_Homo sapiens_hsa000621.03716904
45Type I diabetes mellitus_Homo sapiens_hsa049401.02505405
46Chemical carcinogenesis_Homo sapiens_hsa052041.01734239
47Glutathione metabolism_Homo sapiens_hsa004801.00585832
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.98639792
49Taste transduction_Homo sapiens_hsa047420.97392699
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91212910
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90385460
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89398443
53Renin-angiotensin system_Homo sapiens_hsa046140.88527830
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.88134106
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85403091
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.84116198
57RNA transport_Homo sapiens_hsa030130.81328363
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81009142
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80395627
60Linoleic acid metabolism_Homo sapiens_hsa005910.79980841
61Ether lipid metabolism_Homo sapiens_hsa005650.79215929
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78030822
63Arachidonic acid metabolism_Homo sapiens_hsa005900.77952744
64Metabolic pathways_Homo sapiens_hsa011000.77832219
65Nitrogen metabolism_Homo sapiens_hsa009100.77087094
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74661608
67Collecting duct acid secretion_Homo sapiens_hsa049660.74409743
68Retinol metabolism_Homo sapiens_hsa008300.74110444
69Folate biosynthesis_Homo sapiens_hsa007900.73348222
70Spliceosome_Homo sapiens_hsa030400.69836101
71Serotonergic synapse_Homo sapiens_hsa047260.69796265
72Caffeine metabolism_Homo sapiens_hsa002320.67018167
73Olfactory transduction_Homo sapiens_hsa047400.66971901
74Pyruvate metabolism_Homo sapiens_hsa006200.63945189
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60309791
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58052070
77Allograft rejection_Homo sapiens_hsa053300.57315997
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56950357
79Nicotine addiction_Homo sapiens_hsa050330.55877191
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.55364455
81Antigen processing and presentation_Homo sapiens_hsa046120.51321273
82Autoimmune thyroid disease_Homo sapiens_hsa053200.48965061
83mRNA surveillance pathway_Homo sapiens_hsa030150.48330678
84Insulin secretion_Homo sapiens_hsa049110.44168824
85Graft-versus-host disease_Homo sapiens_hsa053320.42842618
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42742004
87Primary immunodeficiency_Homo sapiens_hsa053400.41520951
88Oocyte meiosis_Homo sapiens_hsa041140.41369690
89Morphine addiction_Homo sapiens_hsa050320.41344654
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.40944077
91GABAergic synapse_Homo sapiens_hsa047270.40919824
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38192760
93Fatty acid degradation_Homo sapiens_hsa000710.35406750
94One carbon pool by folate_Homo sapiens_hsa006700.34818197
95Rheumatoid arthritis_Homo sapiens_hsa053230.33491945
96Salivary secretion_Homo sapiens_hsa049700.33240839
97Starch and sucrose metabolism_Homo sapiens_hsa005000.31323248
98Fatty acid metabolism_Homo sapiens_hsa012120.31294881
99Phagosome_Homo sapiens_hsa041450.28976960
100Circadian entrainment_Homo sapiens_hsa047130.28860436

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