C8ORF22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of relaxation of muscle (GO:1901077)8.29939578
2actin filament-based movement (GO:0030048)7.80768499
3creatine metabolic process (GO:0006600)7.73947677
4striated muscle contraction (GO:0006941)7.52530823
5response to muscle activity (GO:0014850)7.43055628
6myofibril assembly (GO:0030239)7.40879560
7positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)7.29689043
8response to stimulus involved in regulation of muscle adaptation (GO:0014874)6.94837058
9skeletal muscle fiber development (GO:0048741)6.84145449
10sarcomere organization (GO:0045214)6.72835900
11regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.42186377
12myotube cell development (GO:0014904)6.16668944
13glycogen catabolic process (GO:0005980)6.13897083
14skeletal muscle adaptation (GO:0043501)6.12230412
15response to inactivity (GO:0014854)6.05836294
16plasma membrane repair (GO:0001778)5.83598267
17muscle contraction (GO:0006936)5.83118222
18glucan catabolic process (GO:0009251)5.77850209
19cardiac myofibril assembly (GO:0055003)5.45890279
20cellular polysaccharide catabolic process (GO:0044247)5.42286663
21glycogen biosynthetic process (GO:0005978)5.30459791
22glucan biosynthetic process (GO:0009250)5.30459791
23cardiac muscle contraction (GO:0060048)5.28678648
24muscle system process (GO:0003012)5.19236217
25NADH metabolic process (GO:0006734)5.18646715
26actomyosin structure organization (GO:0031032)5.16549343
27regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.11545989
28regulation of cell communication by electrical coupling (GO:0010649)5.11229606
29muscle fiber development (GO:0048747)5.06491212
30regulation of actin filament-based movement (GO:1903115)4.93496662
31skeletal muscle tissue development (GO:0007519)4.89482911
32polysaccharide catabolic process (GO:0000272)4.88800093
33negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.81863661
34skeletal muscle tissue regeneration (GO:0043403)4.71830987
35striated muscle adaptation (GO:0014888)4.53676561
36fructose metabolic process (GO:0006000)4.50783534
37cardiac muscle hypertrophy (GO:0003300)4.47273266
382-oxoglutarate metabolic process (GO:0006103)4.37293481
39muscle organ morphogenesis (GO:0048644)4.36498017
40glycogen metabolic process (GO:0005977)4.31172416
41muscle cell cellular homeostasis (GO:0046716)4.29985106
42striated muscle hypertrophy (GO:0014897)4.27188451
43negative regulation of potassium ion transmembrane transport (GO:1901380)4.25173198
44glucan metabolic process (GO:0044042)4.22802984
45cellular glucan metabolic process (GO:0006073)4.22802984
46response to activity (GO:0014823)4.16022294
47IMP metabolic process (GO:0046040)4.14172186
48gluconeogenesis (GO:0006094)4.10541408
49muscle cell fate commitment (GO:0042693)4.07986475
50positive regulation of myotube differentiation (GO:0010831)4.01500442
51tricarboxylic acid cycle (GO:0006099)3.96562755
52muscle structure development (GO:0061061)3.92081452
53muscle organ development (GO:0007517)3.91003748
54muscle tissue morphogenesis (GO:0060415)3.90710302
55regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.88652892
56striated muscle atrophy (GO:0014891)3.88114944
57positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.87820551
58striated muscle cell development (GO:0055002)3.86086611
59carnitine shuttle (GO:0006853)3.80692770
60muscle hypertrophy (GO:0014896)3.80269790
61regulation of striated muscle contraction (GO:0006942)3.76688638
62positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.75296843
63regulation of calcium ion transmembrane transport (GO:1903169)3.70707935
64regulation of calcium ion transmembrane transporter activity (GO:1901019)3.70707935
65adult heart development (GO:0007512)3.69092613
66hexose biosynthetic process (GO:0019319)3.67438556
67muscle adaptation (GO:0043500)3.67158839
68cardiac muscle tissue morphogenesis (GO:0055008)3.66301598
69negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.64963410
70negative regulation of calcium ion transmembrane transport (GO:1903170)3.64963410
71myotube differentiation (GO:0014902)3.57891845
72regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.57811687
73neuronal action potential propagation (GO:0019227)3.56470701
74myoblast fusion (GO:0007520)3.53148949
75muscle atrophy (GO:0014889)3.52865517
76cellular carbohydrate catabolic process (GO:0044275)3.52481950
77negative regulation of muscle contraction (GO:0045932)3.51488334
78ubiquinone biosynthetic process (GO:0006744)3.47076063
79cardiac muscle cell development (GO:0055013)3.41978531
80succinate metabolic process (GO:0006105)3.41609971
81regulation of skeletal muscle cell differentiation (GO:2001014)3.38460419
82cardiac muscle adaptation (GO:0014887)3.35538196
83cardiac muscle hypertrophy in response to stress (GO:0014898)3.35538196
84muscle hypertrophy in response to stress (GO:0003299)3.35538196
85muscle cell development (GO:0055001)3.31117699
86striated muscle tissue development (GO:0014706)3.29099428
87AMP metabolic process (GO:0046033)3.28498002
88oxaloacetate metabolic process (GO:0006107)3.28221237
89heart process (GO:0003015)3.27824734
90heart contraction (GO:0060047)3.27824734
91relaxation of muscle (GO:0090075)3.27097558
92positive regulation of cation channel activity (GO:2001259)3.26801171
93neuromuscular synaptic transmission (GO:0007274)3.22332284
94regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.21558759
95muscle filament sliding (GO:0030049)12.8713403
96actin-myosin filament sliding (GO:0033275)12.8713403
97sarcoplasmic reticulum calcium ion transport (GO:0070296)11.9930593
98skeletal muscle contraction (GO:0003009)10.5946591
99actin-mediated cell contraction (GO:0070252)10.5455086
100regulation of skeletal muscle contraction (GO:0014819)10.2581138

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.90738053
2EZH2_22144423_ChIP-Seq_EOC_Human4.64901022
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.64899612
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.81602061
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.80038928
6ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.32625857
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.10599968
8TBX20_22328084_ChIP-Seq_HEART_Mouse3.08604369
9TBX20_22080862_ChIP-Seq_HEART_Mouse3.08604369
10BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.98675690
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.98572359
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.87984150
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.52989670
14MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.36725283
15PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse2.27424730
16EP300_21415370_ChIP-Seq_HL-1_Mouse2.20990953
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.14017211
18ZNF263_19887448_ChIP-Seq_K562_Human2.06991150
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.05370740
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.96950145
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96454522
22GATA4_21415370_ChIP-Seq_HL-1_Mouse1.94162315
23NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.94135299
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91868756
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.87788035
26EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.67631507
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.59561479
28CTCF_27219007_Chip-Seq_Bcells_Human1.53335330
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47689625
30AR_21572438_ChIP-Seq_LNCaP_Human1.42490360
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37495565
32STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.37031142
33NFIB_24661679_ChIP-Seq_LUNG_Mouse1.30129813
34SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27437035
35NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.26731119
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.26123462
37ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23126095
38PPARA_22158963_ChIP-Seq_LIVER_Mouse1.21345054
39CTCF_21964334_ChIP-Seq_BJAB-B_Human1.20999967
40GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.17483850
41SMC3_22415368_ChIP-Seq_MEFs_Mouse1.16479321
42SPI1_20517297_ChIP-Seq_HL60_Human1.16202233
43IGF1R_20145208_ChIP-Seq_DFB_Human1.15041270
44RXR_22158963_ChIP-Seq_LIVER_Mouse1.15029695
45NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14524098
46CLOCK_20551151_ChIP-Seq_293T_Human1.14428089
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14047503
48CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.12131782
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11294093
50DROSHA_22980978_ChIP-Seq_HELA_Human1.10908465
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10697223
52SA1_27219007_Chip-Seq_Bcells_Human1.10514038
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.10134371
54MYC_27129775_Chip-Seq_CORNEA_Mouse1.08501032
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08490949
56SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02891077
57OCT4_20526341_ChIP-Seq_ESCs_Human1.02015246
58STAT1_20625510_ChIP-Seq_HELA_Human1.01921133
59CRX_20693478_ChIP-Seq_RETINA_Mouse1.00909115
60EZH2_27294783_Chip-Seq_ESCs_Mouse0.97913586
61EZH2_27294783_Chip-Seq_NPCs_Mouse0.92686120
62MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.92599508
63CTCF_21964334_Chip-Seq_Bcells_Human0.92159467
64LXR_22158963_ChIP-Seq_LIVER_Mouse0.91907392
65RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91311997
66GATA1_19941827_ChIP-Seq_MEL_Mouse0.91276341
67GATA6_21074721_ChIP-Seq_CACO-2_Human0.91145216
68SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90741766
69OCT4_21477851_ChIP-Seq_ESCs_Mouse0.90488281
70CTCF_27219007_Chip-Seq_ERYTHROID_Human0.87868859
71SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87134893
72EGR1_19032775_ChIP-ChIP_M12_Human0.85546450
73CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85367292
74PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.83401734
75FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.83143368
76KDM2B_26808549_Chip-Seq_DND41_Human0.81911726
77CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.81669047
78PCGF2_27294783_Chip-Seq_ESCs_Mouse0.80915833
79HTT_18923047_ChIP-ChIP_STHdh_Human0.79984938
80SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78509783
81DPY_21335234_ChIP-Seq_ESCs_Mouse0.77680764
82TCF7_22412390_ChIP-Seq_EML_Mouse0.75203989
83CTCF_26484167_Chip-Seq_Bcells_Mouse0.75103812
84NRF2_20460467_ChIP-Seq_MEFs_Mouse0.74492549
85NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.74492549
86LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.73865901
87DNAJC2_21179169_ChIP-ChIP_NT2_Human0.73749692
88TP53_20018659_ChIP-ChIP_R1E_Mouse0.73631868
89RAD21_21589869_ChIP-Seq_MESCs_Mouse0.73103107
90ESR1_21235772_ChIP-Seq_MCF-7_Human0.72983936
91GATA3_21867929_ChIP-Seq_CD8_Mouse0.71686582
92PHF8_20622853_ChIP-Seq_HELA_Human0.71541688
93FLI1_27457419_Chip-Seq_LIVER_Mouse0.71421126
94ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.70804597
95TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.70258535
96ZFP281_18757296_ChIP-ChIP_E14_Mouse0.69801160
97KLF5_20875108_ChIP-Seq_MESCs_Mouse0.69556585
98ER_23166858_ChIP-Seq_MCF-7_Human0.69057890
99GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.68539787
100LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.67627596

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue7.29921214
2MP0004145_abnormal_muscle_electrophysio7.23914169
3MP0000751_myopathy5.85633298
4MP0000749_muscle_degeneration5.80167832
5MP0004036_abnormal_muscle_relaxation4.35016745
6MP0002106_abnormal_muscle_physiology3.78615242
7MP0000747_muscle_weakness3.60719552
8MP0005451_abnormal_body_composition3.57451727
9MP0000759_abnormal_skeletal_muscle3.55689084
10MP0004087_abnormal_muscle_fiber3.46497485
11MP0004233_abnormal_muscle_weight3.21921293
12MP0005369_muscle_phenotype3.19959750
13MP0002332_abnormal_exercise_endurance3.09489638
14MP0002269_muscular_atrophy3.09023236
15MP0004130_abnormal_muscle_cell2.98952692
16MP0004084_abnormal_cardiac_muscle2.97446381
17MP0000750_abnormal_muscle_regeneration2.87415869
18MP0005620_abnormal_muscle_contractility2.80222741
19MP0005330_cardiomyopathy2.64801810
20MP0000733_abnormal_muscle_development2.23339899
21MP0006036_abnormal_mitochondrial_physio2.14269363
22MP0002972_abnormal_cardiac_muscle2.08013824
23MP0002108_abnormal_muscle_morphology1.95156922
24MP0002837_dystrophic_cardiac_calcinosis1.86099885
25MP0000013_abnormal_adipose_tissue1.69974197
26MP0004215_abnormal_myocardial_fiber1.67496277
27MP0004484_altered_response_of1.65256046
28MP0010630_abnormal_cardiac_muscle1.52777918
29MP0005266_abnormal_metabolism1.47910469
30MP0004270_analgesia1.40742888
31MP0006138_congestive_heart_failure1.40661769
32MP0002127_abnormal_cardiovascular_syste1.38706729
33MP0001544_abnormal_cardiovascular_syste1.33415446
34MP0005385_cardiovascular_system_phenoty1.33415446
35MP0004510_myositis1.32454480
36MP0003221_abnormal_cardiomyocyte_apopto1.25351902
37MP0004185_abnormal_adipocyte_glucose1.22902435
38MP0002971_abnormal_brown_adipose1.18168184
39MP0001661_extended_life_span1.12894429
40MP0003950_abnormal_plasma_membrane1.02321967
41MP0005375_adipose_tissue_phenotype0.95558055
42MP0005666_abnormal_adipose_tissue0.94634359
43MP0002822_catalepsy0.92384040
44MP0000003_abnormal_adipose_tissue0.91413913
45MP0008775_abnormal_heart_ventricle0.88711614
46MP0003137_abnormal_impulse_conducting0.85298949
47MP0005670_abnormal_white_adipose0.77819597
48MP0003879_abnormal_hair_cell0.76793172
49MP0004147_increased_porphyrin_level0.73917892
50MP0000372_irregular_coat_pigmentation0.69877239
51MP0003828_pulmonary_edema0.69228898
52MP0009780_abnormal_chondrocyte_physiolo0.69201503
53MP0003656_abnormal_erythrocyte_physiolo0.68545131
54MP0003045_fibrosis0.65747563
55MP0004085_abnormal_heartbeat0.64379476
56MP0000266_abnormal_heart_morphology0.60700327
57MP0004134_abnormal_chest_morphology0.58221744
58MP0002078_abnormal_glucose_homeostasis0.53637019
59MP0004043_abnormal_pH_regulation0.52470377
60MP0010030_abnormal_orbit_morphology0.51212869
61MP0001299_abnormal_eye_distance/0.50890142
62MP0005083_abnormal_biliary_tract0.48924412
63MP0001346_abnormal_lacrimal_gland0.48893739
64MP0009672_abnormal_birth_weight0.44304426
65MP0004142_abnormal_muscle_tone0.43222687
66MP0005584_abnormal_enzyme/coenzyme_acti0.42673284
67MP0005376_homeostasis/metabolism_phenot0.41382041
68MP0008569_lethality_at_weaning0.40002792
69MP0005167_abnormal_blood-brain_barrier0.37539625
70MP0002638_abnormal_pupillary_reflex0.37282049
71MP0005535_abnormal_body_temperature0.37122134
72MP0005452_abnormal_adipose_tissue0.36594388
73MP0005166_decreased_susceptibility_to0.36504099
74MP0005332_abnormal_amino_acid0.35815688
75MP0002114_abnormal_axial_skeleton0.35657522
76MP0000762_abnormal_tongue_morphology0.35148299
77MP0002128_abnormal_blood_circulation0.35084307
78MP0006035_abnormal_mitochondrial_morpho0.33956700
79MP0005334_abnormal_fat_pad0.33856297
80MP0009250_abnormal_appendicular_skeleto0.31531036
81MP0005319_abnormal_enzyme/_coenzyme0.31015933
82MP0003806_abnormal_nucleotide_metabolis0.30243443
83MP0002896_abnormal_bone_mineralization0.28676402
84MP0005423_abnormal_somatic_nervous0.28639416
85MP0003948_abnormal_gas_homeostasis0.28557033
86MP0005187_abnormal_penis_morphology0.25693401
87MP0003959_abnormal_lean_body0.24257235
88MP0000230_abnormal_systemic_arterial0.23972486
89MP0002734_abnormal_mechanical_nocicepti0.23352262
90MP0005165_increased_susceptibility_to0.23223935
91MP0001943_abnormal_respiration0.22056854
92MP0002066_abnormal_motor_capabilities/c0.21134474
93MP0002876_abnormal_thyroid_physiology0.19017925
94MP0004858_abnormal_nervous_system0.16937316
95MP0006276_abnormal_autonomic_nervous0.16057156
96MP0004197_abnormal_fetal_growth/weight/0.14643707
97MP0005645_abnormal_hypothalamus_physiol0.13528432
98MP0009115_abnormal_fat_cell0.13014941
99MP0002067_abnormal_sensory_capabilities0.11672839
100MP0008874_decreased_physiological_sensi0.11341424

Predicted human phenotypes

RankGene SetZ-score
1Type 1 muscle fiber predominance (HP:0003803)8.40980435
2Exercise-induced myalgia (HP:0003738)8.39202402
3Exercise-induced muscle cramps (HP:0003710)7.91764147
4Muscle hypertrophy of the lower extremities (HP:0008968)6.33931578
5Distal arthrogryposis (HP:0005684)5.97428891
6Myopathic facies (HP:0002058)5.93865185
7Calf muscle hypertrophy (HP:0008981)5.60346223
8EMG: myopathic abnormalities (HP:0003458)5.36465140
9Rhabdomyolysis (HP:0003201)5.18134148
10Myoglobinuria (HP:0002913)5.00421565
11Round ear (HP:0100830)4.83082476
12Muscle fiber splitting (HP:0003555)4.78811105
13Centrally nucleated skeletal muscle fibers (HP:0003687)4.69421974
14Hyporeflexia of lower limbs (HP:0002600)4.65585138
15Ulnar deviation of the wrist (HP:0003049)4.59842392
16Abnormality of the calf musculature (HP:0001430)4.53161643
17Rimmed vacuoles (HP:0003805)4.49782198
18Neck muscle weakness (HP:0000467)4.48296861
19Abnormality of the left ventricular outflow tract (HP:0011103)4.29906784
20Subaortic stenosis (HP:0001682)4.29906784
21Abnormality of skeletal muscle fiber size (HP:0012084)4.29612080
22Calcaneovalgus deformity (HP:0001848)4.17954087
23Muscle stiffness (HP:0003552)3.95247191
24Difficulty running (HP:0009046)3.90975255
25Increased connective tissue (HP:0009025)3.71229994
26Deformed tarsal bones (HP:0008119)3.70527221
27Absent phalangeal crease (HP:0006109)3.62702493
28Distal lower limb muscle weakness (HP:0009053)3.49732613
29Increased variability in muscle fiber diameter (HP:0003557)3.49681754
30Frequent falls (HP:0002359)3.43694764
31Asymmetric septal hypertrophy (HP:0001670)3.40036145
32Myotonia (HP:0002486)3.38376350
33Areflexia of lower limbs (HP:0002522)3.34598136
34Malignant hyperthermia (HP:0002047)3.12905461
35Sudden death (HP:0001699)3.10379709
36Abnormal finger flexion creases (HP:0006143)3.01625890
37EMG: neuropathic changes (HP:0003445)2.98678870
38Bundle branch block (HP:0011710)2.88707203
39Generalized muscle weakness (HP:0003324)2.86815722
40Mildly elevated creatine phosphokinase (HP:0008180)2.68122072
41Progressive muscle weakness (HP:0003323)2.52771124
42Distal lower limb amyotrophy (HP:0008944)2.51574352
43Slender build (HP:0001533)2.50769976
44Bulbar palsy (HP:0001283)2.50324977
45Weak cry (HP:0001612)2.42907784
46Abnormality of the calcaneus (HP:0008364)2.42735854
47Dilated cardiomyopathy (HP:0001644)2.42563602
48Scapular winging (HP:0003691)2.42139274
49Limb-girdle muscle atrophy (HP:0003797)2.38551657
50Hyperkalemia (HP:0002153)2.34188161
51Fetal akinesia sequence (HP:0001989)2.33758493
52Gowers sign (HP:0003391)2.29753921
53Spinal rigidity (HP:0003306)2.25278058
54Fatigable weakness (HP:0003473)2.22983432
55Abnormality of the neuromuscular junction (HP:0003398)2.22983432
56Ventricular tachycardia (HP:0004756)2.22610859
57Hip contracture (HP:0003273)2.09136248
58Muscular dystrophy (HP:0003560)2.08004214
59Proximal amyotrophy (HP:0007126)2.07689345
60Lipoatrophy (HP:0100578)2.07336400
61Waddling gait (HP:0002515)2.03480297
62Abnormality of the foot musculature (HP:0001436)2.02060445
63Muscle fiber inclusion bodies (HP:0100299)11.4576500
64Nemaline bodies (HP:0003798)11.3386283
65Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)11.0165195
66Abnormality of the shoulder girdle musculature (HP:0001435)1.99798297
67Difficulty climbing stairs (HP:0003551)1.98890474
68Abnormality of the musculature of the pelvis (HP:0001469)1.94117076
69Abnormality of the hip-girdle musculature (HP:0001445)1.94117076
70Lower limb amyotrophy (HP:0007210)1.92731440
71Ragged-red muscle fibers (HP:0003200)1.90135954
72Exercise intolerance (HP:0003546)1.89492002
73Shoulder girdle muscle weakness (HP:0003547)1.88741091
74Pelvic girdle muscle weakness (HP:0003749)1.88632315
75Foot dorsiflexor weakness (HP:0009027)1.85430003
76Heart block (HP:0012722)1.84316444
77Paralysis (HP:0003470)1.77909694
78Respiratory insufficiency due to muscle weakness (HP:0002747)1.77184719
79Limb-girdle muscle weakness (HP:0003325)1.74745255
80Abnormal atrioventricular conduction (HP:0005150)1.73086369
81Increased intramyocellular lipid droplets (HP:0012240)1.67837874
82Facial diplegia (HP:0001349)1.67641683
83Long clavicles (HP:0000890)1.63331176
84Metatarsus adductus (HP:0001840)1.61747822
85Nonprogressive disorder (HP:0003680)1.61283796
86Ulnar deviation of finger (HP:0009465)1.60424448
87Increased muscle lipid content (HP:0009058)1.55384608
88Ventricular arrhythmia (HP:0004308)1.51536484
89Type 2 muscle fiber atrophy (HP:0003554)1.45642223
90Popliteal pterygium (HP:0009756)1.40420942
91Oligomenorrhea (HP:0000876)1.38120706
92Limited hip movement (HP:0008800)1.37600020
93Muscle fiber atrophy (HP:0100295)1.37268099
94Achilles tendon contracture (HP:0001771)1.35728584
95Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.34795907
96Steppage gait (HP:0003376)1.33585555
97Congenital hip dislocation (HP:0001374)1.26245607
98Short palpebral fissure (HP:0012745)1.24517668
99Adducted thumb (HP:0001181)1.23998459
100Insulin-resistant diabetes mellitus (HP:0000831)1.21563435

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PHKG16.24201475
2PHKG26.24201475
3TTN6.12804054
4PIK3CG2.87971931
5OBSCN11.0380098
6MAPK121.97389216
7PINK11.91298662
8MAP2K31.79530390
9MAP3K71.61084288
10MUSK1.48090043
11NME11.37844734
12MAPKAPK31.31913944
13NEK11.23241851
14EEF2K1.21063809
15TRPM71.20453871
16MAP2K41.16928325
17CCNB11.08067966
18PDK21.02589552
19CAMK2G0.91255748
20MOS0.90723124
21MARK10.88893342
22MAP2K60.86617185
23PRKAA20.84562898
24ERBB30.84396888
25DMPK0.81681115
26LIMK10.78964242
27DYRK1B0.70958552
28PRKAA10.69022022
29MAP3K130.66822918
30MAPK70.60891468
31AKT20.59178335
32NEK90.58405656
33CAMK40.56313341
34BCKDK0.53299790
35MAPK110.52985246
36KSR20.51059969
37RIPK10.48115505
38PRKG10.47956283
39MAP2K10.47705378
40MAPK40.47302574
41PKN10.47261367
42CAMK2D0.44246473
43ICK0.43632173
44LATS20.42316702
45TRIB30.41235961
46SGK30.41190252
47CAMK2B0.40810979
48CAMK2A0.39374233
49CAMK10.37946232
50MAP3K10.36800250
51PIK3CA0.33139982
52RPS6KB20.31769670
53RPS6KB10.31462511
54TBK10.31411903
55ROCK10.31323971
56TAOK20.30067041
57PRKACA0.29592054
58SGK10.28172438
59SGK20.26679752
60TIE10.26536172
61RPS6KA30.25346622
62PRPF4B0.23874890
63MAPK100.23745762
64RPS6KA10.22649054
65MAPK130.22324300
66PRKACB0.21998097
67SIK10.21816672
68PDPK10.18800506
69ARAF0.17857786
70MARK30.17235264
71RAF10.16302217
72MTOR0.15223287
73PRKACG0.12429455
74CDK190.12381501
75RPS6KL10.12181437
76RPS6KC10.12181437
77PDK10.11144915
78LATS10.10934166
79MARK20.09888905
80BRAF0.09231379
81EPHB10.08761549
82MAP3K110.08404366
83RPS6KA60.08078428
84MAP3K100.07894825
85SGK2230.07679064
86SGK4940.07679064
87DAPK20.07540388
88STK110.07367488
89PRKD10.05990867
90ZAP700.05182472
91KSR10.04561370
92GSK3B0.03957322
93FGFR30.03549365
94MAPK30.02673830
95MAP2K20.01954183
96MAPK80.01888694
97MAPK90.01819501
98PAK10.01434591
99MAPK140.00145493
100MAP3K6-0.0037848

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.31864054
2Cardiac muscle contraction_Homo sapiens_hsa042604.10659980
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.07440357
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.04409011
5Dilated cardiomyopathy_Homo sapiens_hsa054143.76368208
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.70513500
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.04807326
8Circadian rhythm_Homo sapiens_hsa047102.78614487
9Carbon metabolism_Homo sapiens_hsa012002.41672095
10Glucagon signaling pathway_Homo sapiens_hsa049222.36422325
11Pentose phosphate pathway_Homo sapiens_hsa000302.20898520
12Arginine biosynthesis_Homo sapiens_hsa002202.20328682
13Arginine and proline metabolism_Homo sapiens_hsa003302.19741683
14Insulin signaling pathway_Homo sapiens_hsa049102.13538557
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.05413719
16Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.04908986
17Fructose and mannose metabolism_Homo sapiens_hsa000511.88270165
18Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.78715857
19Oxytocin signaling pathway_Homo sapiens_hsa049211.78631982
20Calcium signaling pathway_Homo sapiens_hsa040201.72964728
21Parkinsons disease_Homo sapiens_hsa050121.71392437
22Pyruvate metabolism_Homo sapiens_hsa006201.71091991
23Propanoate metabolism_Homo sapiens_hsa006401.70340761
24Insulin resistance_Homo sapiens_hsa049311.65839253
25Alzheimers disease_Homo sapiens_hsa050101.64043731
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.56948174
27Biosynthesis of amino acids_Homo sapiens_hsa012301.48782300
28Fatty acid degradation_Homo sapiens_hsa000711.40454674
29Oxidative phosphorylation_Homo sapiens_hsa001901.34739701
30cGMP-PKG signaling pathway_Homo sapiens_hsa040221.34004153
31AMPK signaling pathway_Homo sapiens_hsa041521.33947107
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32390740
33Starch and sucrose metabolism_Homo sapiens_hsa005001.30303629
34Nitrogen metabolism_Homo sapiens_hsa009101.29652938
35Adipocytokine signaling pathway_Homo sapiens_hsa049201.20261930
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19137350
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15203679
38Phenylalanine metabolism_Homo sapiens_hsa003601.00951991
39Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.00389029
40Vascular smooth muscle contraction_Homo sapiens_hsa042700.98042654
41Fatty acid metabolism_Homo sapiens_hsa012120.95999456
42Gastric acid secretion_Homo sapiens_hsa049710.88193089
43Galactose metabolism_Homo sapiens_hsa000520.83555328
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82552695
45Long-term potentiation_Homo sapiens_hsa047200.81772884
46Huntingtons disease_Homo sapiens_hsa050160.80878294
47GnRH signaling pathway_Homo sapiens_hsa049120.77023994
48Tight junction_Homo sapiens_hsa045300.73096041
49Renin secretion_Homo sapiens_hsa049240.71834236
50Viral myocarditis_Homo sapiens_hsa054160.71500788
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69740044
52Butanoate metabolism_Homo sapiens_hsa006500.59273743
53FoxO signaling pathway_Homo sapiens_hsa040680.55648002
54beta-Alanine metabolism_Homo sapiens_hsa004100.54846308
55Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52989278
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50378527
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46378644
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46040256
59Fatty acid elongation_Homo sapiens_hsa000620.45958317
60Focal adhesion_Homo sapiens_hsa045100.40643425
61PPAR signaling pathway_Homo sapiens_hsa033200.39969589
62Peroxisome_Homo sapiens_hsa041460.39713327
63Insulin secretion_Homo sapiens_hsa049110.39029480
64MAPK signaling pathway_Homo sapiens_hsa040100.38484350
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37683565
66Circadian entrainment_Homo sapiens_hsa047130.34902636
67Tryptophan metabolism_Homo sapiens_hsa003800.34678269
68mTOR signaling pathway_Homo sapiens_hsa041500.34519906
69Long-term depression_Homo sapiens_hsa047300.34431724
70Lysine degradation_Homo sapiens_hsa003100.32993870
71Purine metabolism_Homo sapiens_hsa002300.30782770
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.29400587
73Salivary secretion_Homo sapiens_hsa049700.28342871
74VEGF signaling pathway_Homo sapiens_hsa043700.27157772
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27037792
76HIF-1 signaling pathway_Homo sapiens_hsa040660.25963356
77Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.25806052
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.25356577
79Cholinergic synapse_Homo sapiens_hsa047250.22970130
80Tyrosine metabolism_Homo sapiens_hsa003500.22623666
81Regulation of autophagy_Homo sapiens_hsa041400.22437422
82Glioma_Homo sapiens_hsa052140.19765794
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.19405072
84Histidine metabolism_Homo sapiens_hsa003400.19314534
85Thyroid cancer_Homo sapiens_hsa052160.17093399
86Sulfur relay system_Homo sapiens_hsa041220.16402018
87Oocyte meiosis_Homo sapiens_hsa041140.15485325
88Amphetamine addiction_Homo sapiens_hsa050310.15421573
89Platelet activation_Homo sapiens_hsa046110.15106141
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14456977
91cAMP signaling pathway_Homo sapiens_hsa040240.13901646
92Metabolic pathways_Homo sapiens_hsa011000.12608089
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.09609940
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.09230856
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.09064391
96Olfactory transduction_Homo sapiens_hsa047400.08987847
97Melanogenesis_Homo sapiens_hsa049160.06928454
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.06825231
99Pancreatic secretion_Homo sapiens_hsa049720.06519667
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.06410099

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