C7ORF61

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of inclusion body assembly (GO:0090084)6.28041482
2regulation of inclusion body assembly (GO:0090083)5.03875058
3cell wall macromolecule catabolic process (GO:0016998)4.78201067
4cell wall macromolecule metabolic process (GO:0044036)4.34219929
5cellular response to arsenic-containing substance (GO:0071243)4.33946507
6folic acid transport (GO:0015884)4.00861788
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.77355724
8negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.65453149
9regulation of synapse structural plasticity (GO:0051823)3.47222863
10L-serine transport (GO:0015825)3.43317695
11response to peptidoglycan (GO:0032494)3.41068941
12positive regulation by symbiont of host defense response (GO:0052509)3.39235151
13modulation by symbiont of host defense response (GO:0052031)3.39235151
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.39235151
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.39235151
16positive regulation by organism of defense response of other organism involved in symbiotic interact3.39235151
17modulation by symbiont of host immune response (GO:0052553)3.39235151
18sperm motility (GO:0030317)3.38099243
19adenosine receptor signaling pathway (GO:0001973)3.37677914
20serine transport (GO:0032329)3.37593269
21positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.31256623
22response to acidic pH (GO:0010447)3.20124136
23pyrimidine-containing compound transmembrane transport (GO:0072531)3.15687738
24microglial cell activation (GO:0001774)3.13795597
25regulation of mast cell degranulation (GO:0043304)3.11620306
26G-protein coupled receptor internalization (GO:0002031)3.10581143
27retinal cone cell development (GO:0046549)3.06381785
28RNA destabilization (GO:0050779)3.03727964
29substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.02830327
30substrate-independent telencephalic tangential migration (GO:0021826)3.02830327
31NIK/NF-kappaB signaling (GO:0038061)3.00085512
32viral protein processing (GO:0019082)2.99409537
33germinal center formation (GO:0002467)2.95050786
34negative regulation of Rho protein signal transduction (GO:0035024)2.93785156
35potassium ion export (GO:0071435)2.93784109
36leukocyte migration involved in inflammatory response (GO:0002523)2.93680013
37vitamin transmembrane transport (GO:0035461)2.93537832
38protein refolding (GO:0042026)2.90094634
39regulation of T-helper 2 cell differentiation (GO:0045628)2.84082597
40regulation of mast cell activation involved in immune response (GO:0033006)2.83814545
41regulation of interferon-beta biosynthetic process (GO:0045357)2.80272331
42negative regulation of glial cell proliferation (GO:0060253)2.79086354
43regulation of hippo signaling (GO:0035330)2.77797242
44positive regulation of mast cell activation (GO:0033005)2.74937066
45pyrimidine dimer repair (GO:0006290)2.73249015
46maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.72720044
47potassium ion import (GO:0010107)2.71372169
48positive regulation of mast cell activation involved in immune response (GO:0033008)2.71352553
49positive regulation of mast cell degranulation (GO:0043306)2.71352553
50positive regulation of Cdc42 GTPase activity (GO:0043089)2.69418566
51spermatid nucleus differentiation (GO:0007289)2.69184302
52regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.64236282
53pattern specification involved in kidney development (GO:0061004)2.63301993
54regulation of circadian sleep/wake cycle (GO:0042749)2.62705937
55regulation of circadian sleep/wake cycle, sleep (GO:0045187)2.62705937
56regulation of mast cell activation (GO:0033003)2.62313776
57macrophage activation (GO:0042116)2.60697062
58neutrophil activation involved in immune response (GO:0002283)2.57678825
59base-excision repair, AP site formation (GO:0006285)2.57385124
60positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.56932370
61multicellular organism reproduction (GO:0032504)2.56822858
62central nervous system myelination (GO:0022010)2.56715550
63axon ensheathment in central nervous system (GO:0032291)2.56715550
64regulation of cardiac muscle cell contraction (GO:0086004)2.54761448
65macrophage activation involved in immune response (GO:0002281)2.53271194
66fusion of sperm to egg plasma membrane (GO:0007342)2.52749785
67response to muramyl dipeptide (GO:0032495)2.50916088
68auditory behavior (GO:0031223)2.50405218
69regulation of protein homooligomerization (GO:0032462)2.49923601
70energy homeostasis (GO:0097009)2.49503362
71negative regulation of protein oligomerization (GO:0032460)2.49385770
72cardiac left ventricle morphogenesis (GO:0003214)2.49187692
73negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.48140558
74blood vessel maturation (GO:0001955)2.47737022
75protein polyglutamylation (GO:0018095)2.46004171
76response to gravity (GO:0009629)2.44833358
77alanine transport (GO:0032328)2.43100551
78negative regulation of cell killing (GO:0031342)2.42714042
79negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.42714042
80pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.41432627
81mechanosensory behavior (GO:0007638)2.41418616
82T-helper 1 type immune response (GO:0042088)2.41299875
83purinergic receptor signaling pathway (GO:0035587)2.41283543
84response to pheromone (GO:0019236)2.40622859
85positive regulation of CREB transcription factor activity (GO:0032793)2.39082438
86negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.38438684
87osteoblast development (GO:0002076)2.37555130
88regulation of cilium movement (GO:0003352)2.34990118
89cilium or flagellum-dependent cell motility (GO:0001539)2.33950432
90regulation of myeloid leukocyte mediated immunity (GO:0002886)2.32351853
91G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.31606250
92sequestering of actin monomers (GO:0042989)2.31062587
93phosphatidylethanolamine biosynthetic process (GO:0006646)2.30780968
94negative regulation of oligodendrocyte differentiation (GO:0048715)2.30025106
95negative regulation of lymphocyte mediated immunity (GO:0002707)2.29147413
96spermatid development (GO:0007286)2.29089856
97regulation of leukocyte degranulation (GO:0043300)2.28659820
98positive regulation of regulated secretory pathway (GO:1903307)2.28386412
99regulation of protein kinase A signaling (GO:0010738)2.28101528
100neutrophil activation (GO:0042119)2.27677231

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.00376401
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.17648432
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.84111730
4EZH2_22144423_ChIP-Seq_EOC_Human3.64275721
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.26099283
6AR_21572438_ChIP-Seq_LNCaP_Human2.25109492
7GATA1_19941826_ChIP-Seq_K562_Human2.22868837
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.19072517
9LXR_22292898_ChIP-Seq_THP-1_Human1.98973499
10* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.92122840
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.88837677
12TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83161798
13SPI1_23127762_ChIP-Seq_K562_Human1.82623637
14VDR_21846776_ChIP-Seq_THP-1_Human1.77337561
15KDM2B_26808549_Chip-Seq_SUP-B15_Human1.73109196
16SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.70805995
17KDM2B_26808549_Chip-Seq_DND41_Human1.69726592
18ELK3_25401928_ChIP-Seq_HUVEC_Human1.66660992
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.66517550
20SRY_22984422_ChIP-ChIP_TESTIS_Rat1.62994568
21MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.62504449
22EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.56727257
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.56020952
24ELF1_20517297_ChIP-Seq_JURKAT_Human1.55908156
25MAF_26560356_Chip-Seq_TH1_Human1.54463245
26* BCOR_27268052_Chip-Seq_Bcells_Human1.54092088
27SA1_27219007_Chip-Seq_ERYTHROID_Human1.54004543
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.53898518
29CTCF_20526341_ChIP-Seq_ESCs_Human1.52289333
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52041294
31UTX_26944678_Chip-Seq_JUKART_Human1.50927253
32* BCL6_27268052_Chip-Seq_Bcells_Human1.50038785
33VDR_24763502_ChIP-Seq_THP-1_Human1.48528553
34RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.47272238
35P68_20966046_ChIP-Seq_HELA_Human1.44929084
36GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44163945
37RUNX_20019798_ChIP-Seq_JUKART_Human1.43607322
38SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42113572
39GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40975573
40* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.38913583
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38673406
42GATA1_19941827_ChIP-Seq_MEL_Mouse1.37721503
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36606548
44TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35700835
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35418384
46GATA2_21666600_ChIP-Seq_HMVEC_Human1.33936979
47SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.32620980
48SPI1_20517297_ChIP-Seq_HL60_Human1.32383266
49MAF_26560356_Chip-Seq_TH2_Human1.31335709
50* E2F1_20622854_ChIP-Seq_HELA_Human1.30984795
51KDM2B_26808549_Chip-Seq_JURKAT_Human1.30207128
52KDM2B_26808549_Chip-Seq_K562_Human1.28770424
53PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28585834
54CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28260280
55OCT4_19829295_ChIP-Seq_ESCs_Human1.28154366
56TP53_22127205_ChIP-Seq_IMR90_Human1.26615758
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25951787
58SA1_27219007_Chip-Seq_Bcells_Human1.23108684
59IRF8_21731497_ChIP-ChIP_J774_Mouse1.22250586
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19945119
61ERA_21632823_ChIP-Seq_H3396_Human1.19168493
62GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18572595
63TCF7_22412390_ChIP-Seq_EML_Mouse1.18314245
64TET1_21451524_ChIP-Seq_MESCs_Mouse1.17485148
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15398554
66TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15281052
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13466738
68SMC4_20622854_ChIP-Seq_HELA_Human1.13093738
69KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.12291064
70YY1_22570637_ChIP-Seq_MALME-3M_Human1.11575874
71RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10257110
72SMC3_22415368_ChIP-Seq_MEFs_Mouse1.09929630
73NANOG_20526341_ChIP-Seq_ESCs_Human1.09052612
74SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08874597
75RAC3_21632823_ChIP-Seq_H3396_Human1.08077554
76EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07292474
77DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06785095
78NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05435705
79PHF8_20622854_ChIP-Seq_HELA_Human1.05151066
80* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.05090451
81SCL_19346495_ChIP-Seq_HPC-7_Human1.04911663
82VDR_24787735_ChIP-Seq_THP-1_Human1.04582711
83LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01728878
84MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.01173376
85NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00804815
86RACK7_27058665_Chip-Seq_MCF-7_Human1.00440503
87IRF8_27001747_Chip-Seq_BMDM_Mouse1.00224981
88TP63_22573176_ChIP-Seq_HFKS_Human0.99634582
89* P300_27268052_Chip-Seq_Bcells_Human0.99262498
90EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98584185
91RUNX1_22412390_ChIP-Seq_EML_Mouse0.98500399
92GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97682364
93PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97637704
94EZH2_27294783_Chip-Seq_ESCs_Mouse0.97142813
95RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96433789
96HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96423992
97UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96069106
98VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95831192
99NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.95288852
100P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.94989189

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology3.70141352
2MP0005410_abnormal_fertilization3.17333151
3MP0006054_spinal_hemorrhage3.02175364
4MP0003724_increased_susceptibility_to2.99210044
5MP0003303_peritoneal_inflammation2.93699808
6MP0003011_delayed_dark_adaptation2.85357273
7MP0002928_abnormal_bile_duct2.47908631
8MP0008004_abnormal_stomach_pH2.46801197
9MP0003436_decreased_susceptibility_to2.36266970
10MP0002638_abnormal_pupillary_reflex2.35454208
11MP0005367_renal/urinary_system_phenotyp2.25076076
12MP0000516_abnormal_urinary_system2.25076076
13MP0005084_abnormal_gallbladder_morpholo2.10808138
14MP0000569_abnormal_digit_pigmentation2.02670911
15MP0009278_abnormal_bone_marrow1.93169659
16MP0002419_abnormal_innate_immunity1.92312007
17MP0002822_catalepsy1.88863846
18MP0004510_myositis1.87369857
19MP0005409_darkened_coat_color1.84661045
20MP0009764_decreased_sensitivity_to1.72766863
21MP0003172_abnormal_lysosome_physiology1.71033159
22MP0003656_abnormal_erythrocyte_physiolo1.63402666
23MP0005310_abnormal_salivary_gland1.62249275
24MP0005083_abnormal_biliary_tract1.61723696
25MP0000685_abnormal_immune_system1.59770426
26MP0005423_abnormal_somatic_nervous1.57828481
27MP0002138_abnormal_hepatobiliary_system1.53912315
28MP0009053_abnormal_anal_canal1.53493855
29MP0001502_abnormal_circadian_rhythm1.50625462
30MP0001545_abnormal_hematopoietic_system1.47915489
31MP0005397_hematopoietic_system_phenotyp1.47915489
32MP0005000_abnormal_immune_tolerance1.46415305
33MP0001790_abnormal_immune_system1.41521235
34MP0005387_immune_system_phenotype1.41521235
35MP0005025_abnormal_response_to1.39111524
36MP0002405_respiratory_system_inflammati1.36579042
37MP0005464_abnormal_platelet_physiology1.33240048
38MP0003075_altered_response_to1.33205436
39MP0001533_abnormal_skeleton_physiology1.32913861
40MP0002452_abnormal_antigen_presenting1.32399994
41MP0002723_abnormal_immune_serum1.31766583
42MP0005377_hearing/vestibular/ear_phenot1.29998328
43MP0003878_abnormal_ear_physiology1.29998328
44MP0001800_abnormal_humoral_immune1.29701572
45MP0002148_abnormal_hypersensitivity_rea1.28505633
46MP0002998_abnormal_bone_remodeling1.27953366
47MP0003828_pulmonary_edema1.27750784
48MP0002420_abnormal_adaptive_immunity1.23465513
49MP0001486_abnormal_startle_reflex1.22979238
50MP0008995_early_reproductive_senescence1.21645079
51MP0008260_abnormal_autophagy1.20562411
52MP0001819_abnormal_immune_cell1.19481035
53MP0001970_abnormal_pain_threshold1.19220971
54MP0006082_CNS_inflammation1.17741444
55MP0003698_abnormal_male_reproductive1.17051683
56MP0005164_abnormal_response_to1.13113436
57MP0005167_abnormal_blood-brain_barrier1.11982024
58MP0002733_abnormal_thermal_nociception1.11128768
59MP0009785_altered_susceptibility_to1.09954155
60MP0002132_abnormal_respiratory_system1.09289004
61MP0001348_abnormal_lacrimal_gland1.07588260
62MP0004859_abnormal_synaptic_plasticity1.07458497
63MP0008874_decreased_physiological_sensi1.06946099
64MP0003880_abnormal_central_pattern1.06646216
65MP0000343_altered_response_to1.02885835
66MP0002064_seizures0.99967452
67MP0003279_aneurysm0.99338062
68MP0003136_yellow_coat_color0.98601177
69MP0001501_abnormal_sleep_pattern0.98528808
70MP0001663_abnormal_digestive_system0.96072807
71MP0002277_abnormal_respiratory_mucosa0.93204831
72MP0003633_abnormal_nervous_system0.93001213
73MP0002272_abnormal_nervous_system0.90651150
74MP0005551_abnormal_eye_electrophysiolog0.89045682
75MP0001986_abnormal_taste_sensitivity0.88515456
76MP0001968_abnormal_touch/_nociception0.88416636
77MP0000716_abnormal_immune_system0.87727865
78MP0001853_heart_inflammation0.86697837
79MP0005174_abnormal_tail_pigmentation0.86403071
80MP0002398_abnormal_bone_marrow0.85889485
81MP0001485_abnormal_pinna_reflex0.85143609
82MP0005671_abnormal_response_to0.84558450
83MP0001851_eye_inflammation0.83396248
84MP0002095_abnormal_skin_pigmentation0.81145710
85MP0001929_abnormal_gametogenesis0.80709473
86MP0003690_abnormal_glial_cell0.79901205
87MP0003635_abnormal_synaptic_transmissio0.79809058
88MP0002254_reproductive_system_inflammat0.79398586
89MP0003879_abnormal_hair_cell0.79160186
90MP0000249_abnormal_blood_vessel0.78187770
91MP0000026_abnormal_inner_ear0.77641013
92MP0005623_abnormal_meninges_morphology0.77124457
93MP0009745_abnormal_behavioral_response0.76310907
94MP0002429_abnormal_blood_cell0.75573520
95MP0008569_lethality_at_weaning0.73437822
96MP0003252_abnormal_bile_duct0.72169364
97MP0000613_abnormal_salivary_gland0.70884748
98MP0000689_abnormal_spleen_morphology0.70129507
99MP0001879_abnormal_lymphatic_vessel0.69022563
100MP0005646_abnormal_pituitary_gland0.68704840

Predicted human phenotypes

RankGene SetZ-score
1Retinal dysplasia (HP:0007973)4.13847745
2Type II lissencephaly (HP:0007260)4.01144502
3Cone-rod dystrophy (HP:0000548)3.84172968
4Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.56264686
5Chronic obstructive pulmonary disease (HP:0006510)3.53498986
6Obstructive lung disease (HP:0006536)3.53498986
7Abnormality of the heme biosynthetic pathway (HP:0010472)3.39099315
8Polyphagia (HP:0002591)3.27109358
9Abnormality of the nasal mucosa (HP:0000433)3.22681824
10Nasal polyposis (HP:0100582)3.20381469
11Hemiplegia (HP:0002301)3.19867827
12Abnormality of liposaccharide metabolism (HP:0010968)3.07845643
13Abnormality of glycosphingolipid metabolism (HP:0004343)3.07845643
14Abnormality of glycolipid metabolism (HP:0010969)3.07845643
15Recurrent abscess formation (HP:0002722)3.05024270
16Muscle fiber splitting (HP:0003555)3.04794167
17Abnormality of DNA repair (HP:0003254)3.01808468
18Abnormality of binocular vision (HP:0011514)2.85398462
19Diplopia (HP:0000651)2.85398462
20Axonal loss (HP:0003447)2.78783855
21Hypochromic anemia (HP:0001931)2.73650561
22Myositis (HP:0100614)2.73405349
23Recurrent bacterial skin infections (HP:0005406)2.70650858
24Hypochromic microcytic anemia (HP:0004840)2.70566678
25Abnormal ciliary motility (HP:0012262)2.69422146
26Abnormality of macrophages (HP:0004311)2.69243183
27Autoimmune thrombocytopenia (HP:0001973)2.61556461
28Atonic seizures (HP:0010819)2.58351367
29Spontaneous hematomas (HP:0007420)2.54689915
30Truncus arteriosus (HP:0001660)2.47421649
31Hypertensive crisis (HP:0100735)2.45847236
32Abnormal rod and cone electroretinograms (HP:0008323)2.45551663
33Cortical visual impairment (HP:0100704)2.43115195
34Abnormal hemoglobin (HP:0011902)2.43038078
35Ulnar claw (HP:0001178)2.39757751
36Dyschromatopsia (HP:0007641)2.39431807
37Orchitis (HP:0100796)2.39240147
38Microcytic anemia (HP:0001935)2.37869295
39Stomatitis (HP:0010280)2.34626129
40Adactyly (HP:0009776)2.33063312
41Disinhibition (HP:0000734)2.31651579
42Spastic paraparesis (HP:0002313)2.31512823
43Abnormality of T cell physiology (HP:0011840)2.29927208
44Severe visual impairment (HP:0001141)2.29524078
45Optic neuritis (HP:0100653)2.26773468
46Retrobulbar optic neuritis (HP:0100654)2.26773468
47Facial shape deformation (HP:0011334)2.25580282
48Potter facies (HP:0002009)2.25580282
49Petechiae (HP:0000967)2.24445212
50Mediastinal lymphadenopathy (HP:0100721)2.24097178
51Prolonged neonatal jaundice (HP:0006579)2.22918629
52Recurrent gram-negative bacterial infections (HP:0005420)2.21459893
53Retinal atrophy (HP:0001105)2.20257369
54Segmental peripheral demyelination/remyelination (HP:0003481)2.17991629
55Elevated erythrocyte sedimentation rate (HP:0003565)2.16837913
56Bulbous nose (HP:0000414)2.15992684
57Type I diabetes mellitus (HP:0100651)2.15545316
58Abnormal respiratory motile cilium physiology (HP:0012261)2.15028009
59Esotropia (HP:0000565)2.14990473
60Rapidly progressive (HP:0003678)2.10797147
61Cellulitis (HP:0100658)2.10617229
62Abnormality of the aortic arch (HP:0012303)2.07502713
63Prolonged bleeding time (HP:0003010)2.03814556
64Reticulocytopenia (HP:0001896)1.98175644
65Recurrent sinusitis (HP:0011108)1.96132818
66Slender build (HP:0001533)1.94396399
67Generalized myoclonic seizures (HP:0002123)1.93857164
68Entropion (HP:0000621)1.93610681
69Vasculitis (HP:0002633)1.92897778
70Difficulty climbing stairs (HP:0003551)1.92211301
71Cutaneous photosensitivity (HP:0000992)1.91761624
72Recurrent skin infections (HP:0001581)1.88473075
73Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.87594574
74Vertigo (HP:0002321)1.87525156
75Eczematoid dermatitis (HP:0000976)1.87233550
76Hypoplastic left heart (HP:0004383)1.86902785
77Abnormal eating behavior (HP:0100738)1.84985952
78Recurrent fungal infections (HP:0002841)1.84678388
79Spastic diplegia (HP:0001264)1.84237102
80Meningitis (HP:0001287)1.82347769
81Supranuclear gaze palsy (HP:0000605)1.81610000
82Status epilepticus (HP:0002133)1.80725941
83Polycythemia (HP:0001901)1.80483333
84Abnormal delayed hypersensitivity skin test (HP:0002963)1.79725228
85Agitation (HP:0000713)1.79642012
86Episodic fever (HP:0001954)1.79333315
87Bony spicule pigmentary retinopathy (HP:0007737)1.78748444
88Nuclear cataract (HP:0100018)1.78446249
89Dynein arm defect of respiratory motile cilia (HP:0012255)1.78361985
90Absent/shortened dynein arms (HP:0200106)1.78361985
91Peripheral hypomyelination (HP:0007182)1.75850090
92Abnormality of cells of the erythroid lineage (HP:0012130)1.75495432
93Keratitis (HP:0000491)1.74641819
94Pustule (HP:0200039)1.71112938
95Abnormal number of erythroid precursors (HP:0012131)1.70529780
96Posterior subcapsular cataract (HP:0007787)1.67667183
97Increased IgM level (HP:0003496)1.66720276
98Anomalous pulmonary venous return (HP:0010772)1.66652045
99Anophthalmia (HP:0000528)1.64991778
100Autoimmune hemolytic anemia (HP:0001890)1.64436354

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.33361094
2TESK24.95020696
3PNCK3.30443897
4ERN13.03181690
5PRKD32.37473475
6RIPK42.30902847
7IRAK42.18112017
8TNK22.06325933
9TAOK32.04037022
10TESK12.02307618
11PRPF4B2.00467763
12PTK2B1.92043051
13SIK31.91204188
14TSSK61.87402279
15MAP4K11.87277881
16NTRK31.82940525
17KSR21.79727268
18SIK21.70687623
19MAP3K111.63044575
20BRAF1.62768030
21WNK41.60662024
22IRAK31.56312062
23MAP2K31.54864936
24WNK11.54733101
25CSK1.52660516
26PAK61.49877213
27ARAF1.49615058
28TAOK21.48854907
29STK381.42352146
30TBK11.32789716
31RAF11.28566775
32MAP3K31.20075429
33NUAK11.11481499
34FES1.05288144
35PTK61.03597444
36PLK21.03055419
37IRAK20.99173744
38DDR20.98551953
39PRKD10.98293249
40MARK20.97090054
41IKBKB0.95885644
42PRKD20.91376240
43WEE10.89765770
44BLK0.88205575
45MAPK130.82321138
46TAOK10.80358594
47PDPK10.79662822
48KSR10.79472039
49GRK60.77902464
50CAMK1D0.76300407
51JAK20.74707475
52IKBKE0.73495432
53PDK10.71966920
54PLK40.70200900
55PKN10.68356284
56FGR0.68347046
57MARK10.66114803
58BMX0.65191921
59BTK0.64133711
60EPHB20.64086387
61AKT30.62988123
62MAPK120.61408134
63MAP2K20.59844318
64TGFBR20.58928779
65RPS6KA20.58357325
66PAK30.57501715
67MAP3K10.55840155
68HCK0.53792439
69MARK30.53636249
70JAK30.52471027
71MAP3K130.51248079
72SYK0.50780198
73ROCK20.49643687
74ZAP700.48838755
75CHUK0.48055722
76MAPKAPK30.47103159
77PRKCH0.46379891
78PIM20.46096843
79PRKCQ0.44464593
80TIE10.44355625
81PRKCD0.43741463
82MAP3K80.43734846
83TYK20.42437724
84SGK20.41517244
85PRKCZ0.41016910
86LYN0.40488617
87ABL20.39581041
88IRAK10.39392886
89GRK50.39147055
90LRRK20.39053115
91PRKCI0.38322570
92SIK10.37655098
93NEK60.37335619
94SGK4940.34365236
95SGK2230.34365236
96EPHB10.33738555
97CDK50.33725771
98PRKG10.31780551
99SGK30.30607866
100MAP2K10.30311168

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.58896790
2Notch signaling pathway_Homo sapiens_hsa043302.23794563
3NOD-like receptor signaling pathway_Homo sapiens_hsa046212.22605503
4Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.12740901
5Malaria_Homo sapiens_hsa051442.01781959
6Osteoclast differentiation_Homo sapiens_hsa043801.98372368
7Legionellosis_Homo sapiens_hsa051341.91018709
8Leishmaniasis_Homo sapiens_hsa051401.85823545
9Glycosaminoglycan degradation_Homo sapiens_hsa005311.73532524
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.73342741
11B cell receptor signaling pathway_Homo sapiens_hsa046621.72499940
12Salmonella infection_Homo sapiens_hsa051321.65623922
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.64394059
14Prion diseases_Homo sapiens_hsa050201.60469566
15Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.59950797
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.56161020
17Endocytosis_Homo sapiens_hsa041441.55534230
18Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.51086007
19Other glycan degradation_Homo sapiens_hsa005111.48953425
20Collecting duct acid secretion_Homo sapiens_hsa049661.46933558
21Phototransduction_Homo sapiens_hsa047441.46175480
22Tuberculosis_Homo sapiens_hsa051521.42602405
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.39876056
24Antigen processing and presentation_Homo sapiens_hsa046121.28840068
25Synaptic vesicle cycle_Homo sapiens_hsa047211.27565539
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.25253133
27VEGF signaling pathway_Homo sapiens_hsa043701.22495864
28African trypanosomiasis_Homo sapiens_hsa051431.20935028
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15567576
30Measles_Homo sapiens_hsa051621.15189724
31TNF signaling pathway_Homo sapiens_hsa046681.12835213
32Estrogen signaling pathway_Homo sapiens_hsa049151.11576188
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.06137980
34Influenza A_Homo sapiens_hsa051641.04670767
35Phagosome_Homo sapiens_hsa041451.04004632
36Dopaminergic synapse_Homo sapiens_hsa047280.99318485
37Staphylococcus aureus infection_Homo sapiens_hsa051500.99244730
38SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97611024
39Chemokine signaling pathway_Homo sapiens_hsa040620.96653391
40Pertussis_Homo sapiens_hsa051330.94086115
41Allograft rejection_Homo sapiens_hsa053300.93863120
42Lysosome_Homo sapiens_hsa041420.93757335
43Apoptosis_Homo sapiens_hsa042100.93674610
44Toxoplasmosis_Homo sapiens_hsa051450.93088887
45Rheumatoid arthritis_Homo sapiens_hsa053230.92249819
46cAMP signaling pathway_Homo sapiens_hsa040240.91947968
47Glycerophospholipid metabolism_Homo sapiens_hsa005640.90435200
48Hepatitis B_Homo sapiens_hsa051610.89646239
49MAPK signaling pathway_Homo sapiens_hsa040100.88896823
50Acute myeloid leukemia_Homo sapiens_hsa052210.84445731
51Neurotrophin signaling pathway_Homo sapiens_hsa047220.84154102
52Sphingolipid signaling pathway_Homo sapiens_hsa040710.83795128
53Graft-versus-host disease_Homo sapiens_hsa053320.80616032
54HIF-1 signaling pathway_Homo sapiens_hsa040660.79492376
55Hepatitis C_Homo sapiens_hsa051600.79013978
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78191555
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77967135
58Autoimmune thyroid disease_Homo sapiens_hsa053200.77854058
59Dorso-ventral axis formation_Homo sapiens_hsa043200.77505652
60T cell receptor signaling pathway_Homo sapiens_hsa046600.76841382
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.75693754
62Morphine addiction_Homo sapiens_hsa050320.75187532
63Shigellosis_Homo sapiens_hsa051310.74095099
64Axon guidance_Homo sapiens_hsa043600.73859889
65Glycerolipid metabolism_Homo sapiens_hsa005610.73475318
66Olfactory transduction_Homo sapiens_hsa047400.71039175
67Rap1 signaling pathway_Homo sapiens_hsa040150.69274034
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.68231392
69Choline metabolism in cancer_Homo sapiens_hsa052310.68024902
70Long-term depression_Homo sapiens_hsa047300.66881144
71Nitrogen metabolism_Homo sapiens_hsa009100.64947250
72Renal cell carcinoma_Homo sapiens_hsa052110.64869133
73ABC transporters_Homo sapiens_hsa020100.62910549
74Hematopoietic cell lineage_Homo sapiens_hsa046400.62723283
75Fatty acid biosynthesis_Homo sapiens_hsa000610.60641375
76Circadian entrainment_Homo sapiens_hsa047130.59773344
77p53 signaling pathway_Homo sapiens_hsa041150.59159926
78Epstein-Barr virus infection_Homo sapiens_hsa051690.58970901
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58304608
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56678023
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55915766
82Inositol phosphate metabolism_Homo sapiens_hsa005620.55710256
83Hedgehog signaling pathway_Homo sapiens_hsa043400.55646728
84Herpes simplex infection_Homo sapiens_hsa051680.55103714
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.53919965
86Gastric acid secretion_Homo sapiens_hsa049710.52999410
87Viral myocarditis_Homo sapiens_hsa054160.52723778
88Bladder cancer_Homo sapiens_hsa052190.51626949
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51554678
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51392756
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51313464
92Regulation of autophagy_Homo sapiens_hsa041400.51272251
93Oxytocin signaling pathway_Homo sapiens_hsa049210.51157512
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50686193
95Glutamatergic synapse_Homo sapiens_hsa047240.49790720
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.49788742
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48617744
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46418520
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44939465
100GABAergic synapse_Homo sapiens_hsa047270.43841443

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