C7ORF55

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.27842863
2ATP synthesis coupled proton transport (GO:0015986)6.51968217
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.51968217
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.86353364
5respiratory electron transport chain (GO:0022904)5.43605540
6electron transport chain (GO:0022900)5.38609473
7protein complex biogenesis (GO:0070271)5.23839065
8establishment of protein localization to mitochondrial membrane (GO:0090151)5.13774085
9chaperone-mediated protein transport (GO:0072321)4.98495943
10mitochondrial respiratory chain complex assembly (GO:0033108)4.88584745
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.68047675
12mitochondrial respiratory chain complex I assembly (GO:0032981)4.68047675
13NADH dehydrogenase complex assembly (GO:0010257)4.68047675
14viral transcription (GO:0019083)4.45890721
15translational termination (GO:0006415)4.35572622
16ribosomal small subunit assembly (GO:0000028)4.32766145
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.14614020
18cotranslational protein targeting to membrane (GO:0006613)4.13582501
19protein targeting to ER (GO:0045047)4.06953119
20respiratory chain complex IV assembly (GO:0008535)3.99384640
21cytochrome complex assembly (GO:0017004)3.99378438
22establishment of protein localization to endoplasmic reticulum (GO:0072599)3.89207542
23protein-cofactor linkage (GO:0018065)3.85079205
24protein localization to endoplasmic reticulum (GO:0070972)3.84048442
25hydrogen ion transmembrane transport (GO:1902600)3.79829257
26ATP biosynthetic process (GO:0006754)3.79139194
27translational elongation (GO:0006414)3.75804061
28protein neddylation (GO:0045116)3.72785517
29water-soluble vitamin biosynthetic process (GO:0042364)3.72768082
30proteasome assembly (GO:0043248)3.66091600
31behavioral response to nicotine (GO:0035095)3.65098123
32termination of RNA polymerase III transcription (GO:0006386)3.62960111
33transcription elongation from RNA polymerase III promoter (GO:0006385)3.62960111
34regulation of mitochondrial translation (GO:0070129)3.62407588
35purine nucleoside triphosphate biosynthetic process (GO:0009145)3.62380861
36nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.60181356
37purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.60146723
38proton transport (GO:0015992)3.54251310
39exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.49833288
40hydrogen transport (GO:0006818)3.48087506
41inner mitochondrial membrane organization (GO:0007007)3.47739330
42platelet dense granule organization (GO:0060155)3.44390786
43cullin deneddylation (GO:0010388)3.39559271
44maturation of SSU-rRNA (GO:0030490)3.37494436
45DNA deamination (GO:0045006)3.37167880
46ribosomal small subunit biogenesis (GO:0042274)3.34180920
47viral life cycle (GO:0019058)3.27404703
48tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.27344907
49RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.27344907
50cellular protein complex disassembly (GO:0043624)3.26096247
51translation (GO:0006412)3.22334563
52sequestering of actin monomers (GO:0042989)3.21758278
53protein deneddylation (GO:0000338)3.18319659
54intracellular protein transmembrane import (GO:0044743)3.15882319
55oxidative phosphorylation (GO:0006119)3.14639187
56mannosylation (GO:0097502)3.13484786
57ribonucleoside triphosphate biosynthetic process (GO:0009201)3.13251278
58translational initiation (GO:0006413)3.09065155
59pseudouridine synthesis (GO:0001522)3.08914711
60nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.04278597
61GTP biosynthetic process (GO:0006183)3.00003900
62DNA double-strand break processing (GO:0000729)2.96861336
63peptidyl-histidine modification (GO:0018202)2.93739238
64epithelial cilium movement (GO:0003351)2.92593522
65ribosomal large subunit biogenesis (GO:0042273)2.90333696
66protein targeting to mitochondrion (GO:0006626)2.89112170
67establishment of protein localization to mitochondrion (GO:0072655)2.88387283
68rRNA modification (GO:0000154)2.87631649
69preassembly of GPI anchor in ER membrane (GO:0016254)2.85892243
70nucleoside triphosphate biosynthetic process (GO:0009142)2.83602273
71ubiquinone biosynthetic process (GO:0006744)2.80079855
72nonmotile primary cilium assembly (GO:0035058)2.79695164
73protein localization to mitochondrion (GO:0070585)2.79239102
74cellular component biogenesis (GO:0044085)2.76885469
75negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.75819878
76mitochondrial transport (GO:0006839)2.75594645
77epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.73844617
78cellular ketone body metabolic process (GO:0046950)2.71906508
79DNA damage response, detection of DNA damage (GO:0042769)2.71390836
80protein complex disassembly (GO:0043241)2.67914702
81regulation of cilium movement (GO:0003352)2.66249361
82macromolecular complex disassembly (GO:0032984)2.62628357
83GPI anchor metabolic process (GO:0006505)2.62428071
84base-excision repair, AP site formation (GO:0006285)2.61110713
85pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.60595231
86ubiquinone metabolic process (GO:0006743)2.59398150
87protein targeting to membrane (GO:0006612)2.58745190
88tRNA processing (GO:0008033)2.57012631
89positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.57003690
90spliceosomal snRNP assembly (GO:0000387)2.55423829
91aldehyde catabolic process (GO:0046185)2.52485246
92nuclear-transcribed mRNA catabolic process (GO:0000956)2.51363058
93purine nucleoside monophosphate biosynthetic process (GO:0009127)2.50833007
94purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.50833007
95regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.50740543
96regulation of mitotic spindle checkpoint (GO:1903504)2.50740543
97regulation of cellular amino acid metabolic process (GO:0006521)2.50283050
98regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.48801221
99organelle disassembly (GO:1903008)2.48415775
100ketone body metabolic process (GO:1902224)2.46970972

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.35663781
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.16616204
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.96675489
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.67845814
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.49016026
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.95240549
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.84509930
8ZNF274_21170338_ChIP-Seq_K562_Hela2.71779230
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.57918272
10VDR_22108803_ChIP-Seq_LS180_Human2.49215832
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.42489554
12ELK1_19687146_ChIP-ChIP_HELA_Human2.41508166
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.39828438
14* VDR_23849224_ChIP-Seq_CD4+_Human2.35196166
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.34013879
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.31420372
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.29345678
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.22166585
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.17274098
20IGF1R_20145208_ChIP-Seq_DFB_Human2.14355563
21MYC_18940864_ChIP-ChIP_HL60_Human2.08173930
22FUS_26573619_Chip-Seq_HEK293_Human2.01213797
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.94347403
24* FOXP3_21729870_ChIP-Seq_TREG_Human1.91051974
25EWS_26573619_Chip-Seq_HEK293_Human1.90256027
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.88103883
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.78405026
28EZH2_22144423_ChIP-Seq_EOC_Human1.77219593
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69182346
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.67631001
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58771196
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56827329
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53092094
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52339441
35TP53_22573176_ChIP-Seq_HFKS_Human1.51868317
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49795568
37* TTF2_22483619_ChIP-Seq_HELA_Human1.48708194
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.46140705
39TAF15_26573619_Chip-Seq_HEK293_Human1.46055418
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45439226
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41217708
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40726291
43GBX2_23144817_ChIP-Seq_PC3_Human1.38965222
44P300_19829295_ChIP-Seq_ESCs_Human1.38552229
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38145567
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38140263
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.37483771
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.36532753
49E2F4_17652178_ChIP-ChIP_JURKAT_Human1.36396349
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34531848
51* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33482450
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31790115
53IRF1_19129219_ChIP-ChIP_H3396_Human1.28632943
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27021081
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26505198
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.24965403
57GABP_19822575_ChIP-Seq_HepG2_Human1.24614278
58DCP1A_22483619_ChIP-Seq_HELA_Human1.23310783
59* XRN2_22483619_ChIP-Seq_HELA_Human1.20216783
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18986447
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18140864
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.14647170
63MYC_19030024_ChIP-ChIP_MESCs_Mouse1.13981739
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12807704
65CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12379191
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11916410
67FOXA1_25329375_ChIP-Seq_VCAP_Human1.11798448
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11798448
69RNF2_27304074_Chip-Seq_NSC_Mouse1.11251779
70ER_23166858_ChIP-Seq_MCF-7_Human1.11241151
71SOX2_19829295_ChIP-Seq_ESCs_Human1.10904813
72NANOG_19829295_ChIP-Seq_ESCs_Human1.10904813
73HTT_18923047_ChIP-ChIP_STHdh_Human1.09994007
74AR_20517297_ChIP-Seq_VCAP_Human1.06172703
75SOX2_16153702_ChIP-ChIP_HESCs_Human1.05185501
76* ELK1_22589737_ChIP-Seq_MCF10A_Human1.02759235
77YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02537436
78CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01680880
79HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01371999
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.00577924
81ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97879518
82NCOR_22424771_ChIP-Seq_293T_Human0.97687614
83CBP_20019798_ChIP-Seq_JUKART_Human0.96558385
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96558385
85ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92779289
86PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91358950
87FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88630844
88GATA3_21878914_ChIP-Seq_MCF-7_Human0.88030654
89NFE2_27457419_Chip-Seq_LIVER_Mouse0.87883565
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87580226
91FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.86649561
92BCAT_22108803_ChIP-Seq_LS180_Human0.86465146
93SUZ12_27294783_Chip-Seq_NPCs_Mouse0.84608342
94MYC_19079543_ChIP-ChIP_MESCs_Mouse0.84275278
95ERG_20517297_ChIP-Seq_VCAP_Human0.83788777
96SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.83456503
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83100480
98HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82787556
99AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81072434
100EZH2_27294783_Chip-Seq_NPCs_Mouse0.80898945

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.04457936
2MP0009379_abnormal_foot_pigmentation2.82752664
3MP0002102_abnormal_ear_morphology2.37852805
4MP0006072_abnormal_retinal_apoptosis2.37661683
5MP0003136_yellow_coat_color2.34447955
6MP0002638_abnormal_pupillary_reflex2.33688615
7MP0003880_abnormal_central_pattern2.32111801
8MP0002837_dystrophic_cardiac_calcinosis2.29081694
9MP0000372_irregular_coat_pigmentation2.25987299
10MP0002938_white_spotting2.19072677
11MP0001529_abnormal_vocalization2.17604340
12MP0008058_abnormal_DNA_repair1.95193275
13MP0003011_delayed_dark_adaptation1.93846574
14MP0003806_abnormal_nucleotide_metabolis1.91511870
15MP0005551_abnormal_eye_electrophysiolog1.90257340
16MP0008877_abnormal_DNA_methylation1.89449702
17MP0004142_abnormal_muscle_tone1.86770829
18MP0001968_abnormal_touch/_nociception1.86606602
19MP0004145_abnormal_muscle_electrophysio1.82327741
20MP0005253_abnormal_eye_physiology1.80524080
21MP0005645_abnormal_hypothalamus_physiol1.77231511
22MP0002736_abnormal_nociception_after1.76444966
23MP0005084_abnormal_gallbladder_morpholo1.74232469
24MP0005646_abnormal_pituitary_gland1.70871370
25MP0006036_abnormal_mitochondrial_physio1.67631689
26MP0001905_abnormal_dopamine_level1.66503770
27MP0008875_abnormal_xenobiotic_pharmacok1.66237237
28MP0003186_abnormal_redox_activity1.66023569
29MP0003195_calcinosis1.63945500
30MP0009046_muscle_twitch1.63201109
31MP0002234_abnormal_pharynx_morphology1.60546013
32MP0003718_maternal_effect1.59236588
33MP0004133_heterotaxia1.57119919
34MP0001984_abnormal_olfaction1.55077805
35MP0000631_abnormal_neuroendocrine_gland1.53920478
36MP0006276_abnormal_autonomic_nervous1.53413783
37MP0002272_abnormal_nervous_system1.51339428
38MP0009745_abnormal_behavioral_response1.45524469
39MP0008789_abnormal_olfactory_epithelium1.42663365
40MP0001485_abnormal_pinna_reflex1.41393300
41MP0005174_abnormal_tail_pigmentation1.39245923
42MP0002277_abnormal_respiratory_mucosa1.38948454
43MP0008995_early_reproductive_senescence1.38540219
44MP0008872_abnormal_physiological_respon1.37500113
45MP0002653_abnormal_ependyma_morphology1.33369000
46MP0002160_abnormal_reproductive_system1.31891723
47MP0010386_abnormal_urinary_bladder1.30614272
48MP0006035_abnormal_mitochondrial_morpho1.27358319
49MP0002095_abnormal_skin_pigmentation1.26030209
50MP0002822_catalepsy1.23445049
51MP0001764_abnormal_homeostasis1.23342899
52MP0004147_increased_porphyrin_level1.23032125
53MP0003787_abnormal_imprinting1.22045771
54MP0002876_abnormal_thyroid_physiology1.18988421
55MP0002163_abnormal_gland_morphology1.16434099
56MP0001293_anophthalmia1.15746139
57MP0005075_abnormal_melanosome_morpholog1.13432543
58MP0001986_abnormal_taste_sensitivity1.12736985
59MP0002735_abnormal_chemical_nociception1.12629665
60MP0005389_reproductive_system_phenotype1.11020698
61MP0002557_abnormal_social/conspecific_i1.10584412
62MP0005379_endocrine/exocrine_gland_phen1.08247325
63MP0003283_abnormal_digestive_organ1.07337811
64MP0003121_genomic_imprinting1.05563458
65MP0001486_abnormal_startle_reflex1.03235576
66MP0004885_abnormal_endolymph1.00437395
67MP0002928_abnormal_bile_duct0.99739905
68MP0001970_abnormal_pain_threshold0.99734424
69MP0005332_abnormal_amino_acid0.99524998
70MP0003786_premature_aging0.99491711
71MP0002572_abnormal_emotion/affect_behav0.97914434
72MP0000049_abnormal_middle_ear0.97903839
73MP0002064_seizures0.97075238
74MP0003646_muscle_fatigue0.96164578
75MP0002751_abnormal_autonomic_nervous0.95840958
76MP0002733_abnormal_thermal_nociception0.95234392
77MP0009697_abnormal_copulation0.93287756
78MP0005195_abnormal_posterior_eye0.92569484
79MP0000026_abnormal_inner_ear0.92458606
80MP0004742_abnormal_vestibular_system0.92412735
81MP0003122_maternal_imprinting0.90891969
82MP0005423_abnormal_somatic_nervous0.90292732
83MP0005394_taste/olfaction_phenotype0.89609746
84MP0005499_abnormal_olfactory_system0.89609746
85MP0003938_abnormal_ear_development0.88546115
86MP0002752_abnormal_somatic_nervous0.88504237
87MP0005171_absent_coat_pigmentation0.87943374
88MP0000569_abnormal_digit_pigmentation0.85544474
89MP0001324_abnormal_eye_pigmentation0.84810380
90MP0002734_abnormal_mechanical_nocicepti0.83730338
91MP0002210_abnormal_sex_determination0.83387192
92MP0005386_behavior/neurological_phenoty0.82203200
93MP0004924_abnormal_behavior0.82203200
94MP0005391_vision/eye_phenotype0.82101231
95MP0002184_abnormal_innervation0.82000276
96MP0002067_abnormal_sensory_capabilities0.79906996
97MP0002282_abnormal_trachea_morphology0.79630895
98MP0005410_abnormal_fertilization0.78495152
99MP0003137_abnormal_impulse_conducting0.77783309
100MP0001919_abnormal_reproductive_system0.76716699

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.02725928
2Mitochondrial inheritance (HP:0001427)4.75307192
3Abnormal mitochondria in muscle tissue (HP:0008316)4.53994735
4Increased hepatocellular lipid droplets (HP:0006565)4.43602900
5Acute encephalopathy (HP:0006846)4.43388038
6Progressive macrocephaly (HP:0004481)4.27978654
7Increased CSF lactate (HP:0002490)4.21524356
8Lipid accumulation in hepatocytes (HP:0006561)4.19583407
9Hepatocellular necrosis (HP:0001404)3.90398311
10Renal Fanconi syndrome (HP:0001994)3.82465975
113-Methylglutaconic aciduria (HP:0003535)3.72881215
12Hepatic necrosis (HP:0002605)3.69178423
13Pancreatic cysts (HP:0001737)3.53089907
14Abnormal number of erythroid precursors (HP:0012131)3.39987216
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.33157764
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.33157764
17Molar tooth sign on MRI (HP:0002419)3.27015376
18Abnormality of midbrain morphology (HP:0002418)3.27015376
19Increased intramyocellular lipid droplets (HP:0012240)3.26771471
20Cerebral edema (HP:0002181)3.26612883
21Pancreatic fibrosis (HP:0100732)3.24719019
22True hermaphroditism (HP:0010459)3.19331768
23Abnormality of cells of the erythroid lineage (HP:0012130)3.17553318
24Nephronophthisis (HP:0000090)3.01309742
25Exertional dyspnea (HP:0002875)2.93244122
26Lactic acidosis (HP:0003128)2.85461461
27Methylmalonic acidemia (HP:0002912)2.85426710
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.81208292
29Optic disc pallor (HP:0000543)2.77607854
30Congenital, generalized hypertrichosis (HP:0004540)2.77383565
31Medial flaring of the eyebrow (HP:0010747)2.77057242
32Increased muscle lipid content (HP:0009058)2.76195562
33Increased serum lactate (HP:0002151)2.70852269
34Methylmalonic aciduria (HP:0012120)2.68346268
35Reticulocytopenia (HP:0001896)2.64709504
36Respiratory failure (HP:0002878)2.58717421
37Abnormality of renal resorption (HP:0011038)2.55286006
38Macrocytic anemia (HP:0001972)2.54093433
39Type II lissencephaly (HP:0007260)2.45344249
40Exercise intolerance (HP:0003546)2.43470428
41Abnormality of urine glucose concentration (HP:0011016)2.41802228
42Glycosuria (HP:0003076)2.41802228
43Congenital stationary night blindness (HP:0007642)2.39091648
44Abnormality of the renal medulla (HP:0100957)2.35413133
45Sclerocornea (HP:0000647)2.33983157
46Type I transferrin isoform profile (HP:0003642)2.30628155
47Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.30506562
48Lethargy (HP:0001254)2.27569769
49Hypothermia (HP:0002045)2.23350925
50Leukodystrophy (HP:0002415)2.21381655
51Gait imbalance (HP:0002141)2.20698991
52Respiratory difficulties (HP:0002880)2.17368936
53Congenital primary aphakia (HP:0007707)2.15591835
54Abnormality of the renal cortex (HP:0011035)2.11061054
55Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.07468506
56Abnormal respiratory motile cilium morphology (HP:0005938)2.06451096
57Abnormal respiratory epithelium morphology (HP:0012253)2.06451096
58Pendular nystagmus (HP:0012043)2.05574959
59Large for gestational age (HP:0001520)2.01457388
60Renal cortical cysts (HP:0000803)2.00928461
61Colon cancer (HP:0003003)2.00104937
62Hyperglycinemia (HP:0002154)1.99481574
63Nephrogenic diabetes insipidus (HP:0009806)1.98537127
64Abnormal protein N-linked glycosylation (HP:0012347)1.98259505
65Abnormal protein glycosylation (HP:0012346)1.98259505
66Abnormal glycosylation (HP:0012345)1.98259505
67Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.98259505
68Abnormal respiratory motile cilium physiology (HP:0012261)1.98148112
69Generalized aminoaciduria (HP:0002909)1.97699558
70Abnormality of the pons (HP:0007361)1.97605596
71Abnormal rod and cone electroretinograms (HP:0008323)1.97171891
72Anencephaly (HP:0002323)1.96838700
73Hypoplasia of the pons (HP:0012110)1.96689188
74Cystic liver disease (HP:0006706)1.92460792
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91903632
76Abnormality of alanine metabolism (HP:0010916)1.91903632
77Hyperalaninemia (HP:0003348)1.91903632
78Abnormal ciliary motility (HP:0012262)1.89943467
79Male pseudohermaphroditism (HP:0000037)1.89521747
80Hyperphosphaturia (HP:0003109)1.88951496
81Absent thumb (HP:0009777)1.81197680
82Abolished electroretinogram (ERG) (HP:0000550)1.80022458
83Dynein arm defect of respiratory motile cilia (HP:0012255)1.79476385
84Absent/shortened dynein arms (HP:0200106)1.79476385
85Attenuation of retinal blood vessels (HP:0007843)1.79238264
86Retinal dysplasia (HP:0007973)1.79064888
87Rhinitis (HP:0012384)1.77799983
88CNS demyelination (HP:0007305)1.77640434
89Genital tract atresia (HP:0001827)1.77095045
90Abnormality of dicarboxylic acid metabolism (HP:0010995)1.76801955
91Dicarboxylic aciduria (HP:0003215)1.76801955
92Septo-optic dysplasia (HP:0100842)1.76271355
93Concave nail (HP:0001598)1.76206730
94Vaginal atresia (HP:0000148)1.75877907
95Focal motor seizures (HP:0011153)1.74353474
96Aplasia/Hypoplasia of the tongue (HP:0010295)1.73547541
97Pallor (HP:0000980)1.72983302
98X-linked dominant inheritance (HP:0001423)1.72529361
99Furrowed tongue (HP:0000221)1.71916563
100Abnormality of vitamin B metabolism (HP:0004340)1.70173452

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.93993491
2ZAK3.24675708
3MAP4K22.99689912
4FRK2.65444768
5STK162.46568735
6TLK12.46324581
7NUAK12.42593071
8VRK12.25698007
9WNK32.21919315
10ADRBK22.19028155
11BUB12.16612703
12BCKDK2.13475116
13BMPR1B2.06106554
14GRK11.88062532
15TNIK1.82626950
16CASK1.75579712
17NME11.75429196
18DYRK21.62509190
19PINK11.54869666
20MAP3K41.53107988
21WNK41.51942974
22SRPK11.46553456
23MAPK131.38155967
24MAP2K71.37386489
25MST41.35046583
26PHKG11.34933410
27PHKG21.34933410
28TRIM281.34193217
29TAF11.29307578
30INSRR1.26853138
31PLK31.16654230
32TXK1.15263285
33PNCK1.14099240
34MARK11.13022857
35CDC71.11669727
36TAOK31.11357981
37OBSCN1.03394143
38PBK0.98812820
39DYRK30.97783782
40CCNB10.97405084
41WEE10.96752393
42CSNK1G20.96066203
43OXSR10.94206805
44CSNK1G30.92820271
45PRKCG0.90581964
46PLK40.89243381
47TIE10.86343381
48BRSK20.85249705
49PLK20.84043160
50MAPK150.83289816
51RPS6KA50.83135879
52ACVR1B0.81728163
53NEK10.81637650
54CSNK1G10.81221520
55LIMK10.80599495
56PDK20.79786158
57MKNK10.78827652
58MUSK0.78527529
59STK390.78397780
60CDK80.78200651
61PAK30.77895362
62EIF2AK30.76743597
63ADRBK10.73054347
64PIM20.72518990
65MAPKAPK50.72477797
66PRKCE0.70184049
67CDK190.69693311
68MKNK20.68838955
69PLK10.68805131
70PASK0.68615053
71MAP2K60.68411908
72MAP3K120.62475478
73ERBB30.59674212
74FGFR20.59052949
75PRKCI0.58717512
76CSNK1A1L0.58474167
77CHEK20.55519834
78TGFBR10.54177154
79PKN10.53061283
80CSNK2A10.50808726
81CSNK2A20.49324074
82CAMKK20.48360359
83EIF2AK20.47928780
84AURKB0.47683522
85DAPK20.47583895
86PRKACA0.46921220
87ATR0.46769747
88GRK50.44637172
89CDK30.42962618
90NME20.42202260
91CAMK2A0.41964217
92KDR0.41756579
93CSNK1A10.41621465
94EPHB20.41170515
95AURKA0.40907835
96STK38L0.40793348
97TTK0.40711961
98IKBKB0.38082057
99EPHA40.36706999
100EIF2AK10.36027849

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.84263003
2Parkinsons disease_Homo sapiens_hsa050124.08731413
3Ribosome_Homo sapiens_hsa030104.02928634
4Proteasome_Homo sapiens_hsa030503.04162876
5Protein export_Homo sapiens_hsa030602.99579330
6Huntingtons disease_Homo sapiens_hsa050162.83838987
7Alzheimers disease_Homo sapiens_hsa050102.74875364
8RNA polymerase_Homo sapiens_hsa030202.67514497
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.42573312
10Cardiac muscle contraction_Homo sapiens_hsa042602.18019010
11Homologous recombination_Homo sapiens_hsa034402.17963217
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.99283232
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91310065
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.84507243
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.55897999
16Mismatch repair_Homo sapiens_hsa034301.53700410
17Propanoate metabolism_Homo sapiens_hsa006401.52809370
18Butanoate metabolism_Homo sapiens_hsa006501.51576650
19Fanconi anemia pathway_Homo sapiens_hsa034601.48695622
20Basal transcription factors_Homo sapiens_hsa030221.45899079
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43903848
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41610842
23Phototransduction_Homo sapiens_hsa047441.34199245
24One carbon pool by folate_Homo sapiens_hsa006701.32947818
25RNA degradation_Homo sapiens_hsa030181.32166092
26Pyrimidine metabolism_Homo sapiens_hsa002401.30543087
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28955385
28Nucleotide excision repair_Homo sapiens_hsa034201.26443099
29DNA replication_Homo sapiens_hsa030301.19965119
30Fatty acid elongation_Homo sapiens_hsa000621.18554475
31Peroxisome_Homo sapiens_hsa041461.12962979
32Sulfur metabolism_Homo sapiens_hsa009201.10488460
33Tryptophan metabolism_Homo sapiens_hsa003801.10328184
34Nitrogen metabolism_Homo sapiens_hsa009101.10322933
35Spliceosome_Homo sapiens_hsa030401.09995140
36Folate biosynthesis_Homo sapiens_hsa007901.09682493
37Base excision repair_Homo sapiens_hsa034101.08279988
38Purine metabolism_Homo sapiens_hsa002301.07970531
39Linoleic acid metabolism_Homo sapiens_hsa005911.06579018
40Caffeine metabolism_Homo sapiens_hsa002321.05442424
41Sulfur relay system_Homo sapiens_hsa041221.05408343
42Collecting duct acid secretion_Homo sapiens_hsa049661.00994018
43Nicotine addiction_Homo sapiens_hsa050330.97702253
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91419357
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89962800
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89437452
47Chemical carcinogenesis_Homo sapiens_hsa052040.89373616
48Metabolic pathways_Homo sapiens_hsa011000.88626743
49Selenocompound metabolism_Homo sapiens_hsa004500.88301224
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86489779
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84165459
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82861736
53Glutathione metabolism_Homo sapiens_hsa004800.82788024
54Non-homologous end-joining_Homo sapiens_hsa034500.80861232
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80644120
56RNA transport_Homo sapiens_hsa030130.79221279
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78776962
58Pyruvate metabolism_Homo sapiens_hsa006200.77539073
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77228380
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.77209184
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73210336
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71817484
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.70235749
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67627761
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67275464
66Regulation of autophagy_Homo sapiens_hsa041400.66730451
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.64808587
68Retinol metabolism_Homo sapiens_hsa008300.62537387
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61618576
70beta-Alanine metabolism_Homo sapiens_hsa004100.60059149
71Olfactory transduction_Homo sapiens_hsa047400.59685686
72Taste transduction_Homo sapiens_hsa047420.56527359
73Ether lipid metabolism_Homo sapiens_hsa005650.55717334
74Steroid biosynthesis_Homo sapiens_hsa001000.54950116
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53125619
76Arachidonic acid metabolism_Homo sapiens_hsa005900.50662522
77Vitamin digestion and absorption_Homo sapiens_hsa049770.48218519
78Fatty acid metabolism_Homo sapiens_hsa012120.47589062
79Fatty acid degradation_Homo sapiens_hsa000710.47275893
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46387639
81Tyrosine metabolism_Homo sapiens_hsa003500.43278955
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42806631
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40402156
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.39361840
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37101587
86Arginine and proline metabolism_Homo sapiens_hsa003300.34405692
87GABAergic synapse_Homo sapiens_hsa047270.33760647
88Basal cell carcinoma_Homo sapiens_hsa052170.32122324
89Morphine addiction_Homo sapiens_hsa050320.31209189
90Systemic lupus erythematosus_Homo sapiens_hsa053220.30330516
91Asthma_Homo sapiens_hsa053100.30209254
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28126819
93Mineral absorption_Homo sapiens_hsa049780.27624548
94Serotonergic synapse_Homo sapiens_hsa047260.26386332
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.25121142
96Fat digestion and absorption_Homo sapiens_hsa049750.24303593
97Rheumatoid arthritis_Homo sapiens_hsa053230.23754969
98Hedgehog signaling pathway_Homo sapiens_hsa043400.23034865
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22047650
100Circadian rhythm_Homo sapiens_hsa047100.19868688

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