C7ORF50

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.11832693
2protein maturation by protein folding (GO:0022417)4.70985934
3pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.57399239
4regulation of mitochondrial translation (GO:0070129)4.42588470
5peptidyl-arginine omega-N-methylation (GO:0035247)4.27257277
6negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.22345381
7protein retention in ER lumen (GO:0006621)4.21172079
8base-excision repair, AP site formation (GO:0006285)4.20115864
9GDP-mannose metabolic process (GO:0019673)4.01189339
10guanosine-containing compound biosynthetic process (GO:1901070)4.00156635
11Golgi transport vesicle coating (GO:0048200)3.96284248
12COPI coating of Golgi vesicle (GO:0048205)3.96284248
13chaperone-mediated protein transport (GO:0072321)3.89549039
14nuclear envelope reassembly (GO:0031468)3.83229316
15mitotic nuclear envelope reassembly (GO:0007084)3.83229316
16pyrimidine nucleotide catabolic process (GO:0006244)3.78851720
17pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.74946916
18GTP biosynthetic process (GO:0006183)3.74405543
19protein insertion into membrane (GO:0051205)3.73644142
20pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.71761982
21histone arginine methylation (GO:0034969)3.71359857
22UTP biosynthetic process (GO:0006228)3.69942547
23maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.69207854
24nucleobase-containing small molecule interconversion (GO:0015949)3.61454637
25CTP metabolic process (GO:0046036)3.56999179
26CTP biosynthetic process (GO:0006241)3.56999179
27mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.56864225
28L-serine metabolic process (GO:0006563)3.55317790
29pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.54742924
30pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.52385940
31ATP synthesis coupled proton transport (GO:0015986)3.43409534
32energy coupled proton transport, down electrochemical gradient (GO:0015985)3.43409534
33retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.43375664
34deoxyribonucleotide catabolic process (GO:0009264)3.41274489
35proteasome assembly (GO:0043248)3.41010698
36protein targeting to mitochondrion (GO:0006626)3.39105429
372-deoxyribonucleotide biosynthetic process (GO:0009265)3.36832057
38deoxyribose phosphate biosynthetic process (GO:0046385)3.36832057
39UTP metabolic process (GO:0046051)3.31973761
40metallo-sulfur cluster assembly (GO:0031163)3.30945210
41iron-sulfur cluster assembly (GO:0016226)3.30945210
42ribosomal small subunit biogenesis (GO:0042274)3.30380941
43proline biosynthetic process (GO:0006561)3.29054075
44pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.27565904
45peptidyl-arginine N-methylation (GO:0035246)3.25771803
46peptidyl-arginine methylation (GO:0018216)3.25771803
47establishment of protein localization to mitochondrion (GO:0072655)3.23773197
48mitochondrial fusion (GO:0008053)3.22439029
49mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.20000185
50respiratory electron transport chain (GO:0022904)3.19829864
51positive regulation of mitochondrial fission (GO:0090141)3.18633668
52establishment of mitochondrion localization (GO:0051654)3.17808809
53electron transport chain (GO:0022900)3.15595560
54deoxyribose phosphate catabolic process (GO:0046386)3.15063772
55protein complex biogenesis (GO:0070271)3.05491047
56protein localization to mitochondrion (GO:0070585)3.03837158
57establishment of protein localization to mitochondrial membrane (GO:0090151)3.03595625
58regulation of mammary gland epithelial cell proliferation (GO:0033599)2.96317725
592-deoxyribonucleotide metabolic process (GO:0009394)2.95509163
60negative regulation of DNA-templated transcription, elongation (GO:0032785)2.95074801
61establishment of viral latency (GO:0019043)2.94743211
62regulation of cellular amino acid metabolic process (GO:0006521)2.93305891
63negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.92531898
64pentose-phosphate shunt (GO:0006098)2.91590408
65mitochondrial respiratory chain complex assembly (GO:0033108)2.90245547
66mitochondrial respiratory chain complex I assembly (GO:0032981)2.89617018
67NADH dehydrogenase complex assembly (GO:0010257)2.89617018
68mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.89617018
69mitochondrial calcium ion transport (GO:0006851)2.89110789
70de novo posttranslational protein folding (GO:0051084)2.87282715
71regulation of translational fidelity (GO:0006450)2.86544904
72glucose catabolic process (GO:0006007)2.84923113
73negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.82999348
74formation of translation preinitiation complex (GO:0001731)2.82462795
75pentose metabolic process (GO:0019321)2.81445701
76regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.79879137
77prostanoid biosynthetic process (GO:0046457)2.79843468
78prostaglandin biosynthetic process (GO:0001516)2.79843468
79ribosomal small subunit assembly (GO:0000028)2.79262389
80viral transcription (GO:0019083)2.79241452
81de novo protein folding (GO:0006458)2.78714725
82ncRNA 3-end processing (GO:0043628)2.77277934
83establishment of integrated proviral latency (GO:0075713)2.75188945
84positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.74756673
85deoxyribose phosphate metabolic process (GO:0019692)2.73001080
86purine deoxyribonucleotide catabolic process (GO:0009155)2.70416669
87negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.70042001
88virion assembly (GO:0019068)2.69390456
89negative regulation of ligase activity (GO:0051352)2.68421401
90negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.68421401
91translational elongation (GO:0006414)2.66748251
92cellular component biogenesis (GO:0044085)2.65986138
93mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.65913527
94termination of RNA polymerase III transcription (GO:0006386)2.63983451
95transcription elongation from RNA polymerase III promoter (GO:0006385)2.63983451
96negative regulation of cell size (GO:0045792)2.63806831
97ribonucleoside triphosphate biosynthetic process (GO:0009201)2.62548237
98maturation of SSU-rRNA (GO:0030490)2.61202202
99oxidative phosphorylation (GO:0006119)2.60893165
100regulation of cellular respiration (GO:0043457)2.60197413

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.49895672
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.42521500
3HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.23685922
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.11294957
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.68759790
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.67354659
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.52233454
8THAP11_20581084_ChIP-Seq_MESCs_Mouse2.36336972
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.27618707
10XRN2_22483619_ChIP-Seq_HELA_Human2.21291135
11ZNF263_19887448_ChIP-Seq_K562_Human2.19921272
12CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.17662275
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.11660053
14DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.06607600
15TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04323439
16GABP_19822575_ChIP-Seq_HepG2_Human2.03239065
17LXR_22292898_ChIP-Seq_THP-1_Human2.02516695
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.01459068
19CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.00478875
20SRY_22984422_ChIP-ChIP_TESTIS_Rat1.96960142
21TET1_21451524_ChIP-Seq_MESCs_Mouse1.93009461
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.92536232
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.92166312
24DCP1A_22483619_ChIP-Seq_HELA_Human1.89281665
25MYC_19030024_ChIP-ChIP_MESCs_Mouse1.86024273
26NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78896497
27E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77916985
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.70164969
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.69184859
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.69050256
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.67662417
32SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.64693667
33ZFX_18555785_ChIP-Seq_MESCs_Mouse1.64657625
34VDR_21846776_ChIP-Seq_THP-1_Human1.63947753
35P68_20966046_ChIP-Seq_HELA_Human1.63808501
36ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60863416
37CTCF_18555785_ChIP-Seq_MESCs_Mouse1.60225997
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.59669159
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.59560098
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.55995395
41RACK7_27058665_Chip-Seq_MCF-7_Human1.54722197
42ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.52008199
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.46936871
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.45003110
45ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.43885705
46CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.43177305
47FOXP1_21924763_ChIP-Seq_HESCs_Human1.37446826
48KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35467684
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35230655
50ELK3_25401928_ChIP-Seq_HUVEC_Human1.34812365
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.34470869
52SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34270685
53KDM5A_27292631_Chip-Seq_BREAST_Human1.32833784
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30713778
55KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30191583
56ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29366724
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28197506
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27877969
59TTF2_22483619_ChIP-Seq_HELA_Human1.27397091
60EST1_17652178_ChIP-ChIP_JURKAT_Human1.27132728
61ELF1_20517297_ChIP-Seq_JURKAT_Human1.26585524
62SMC4_20622854_ChIP-Seq_HELA_Human1.24577870
63* BCL6_27268052_Chip-Seq_Bcells_Human1.24193896
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22982616
65TBX5_21415370_ChIP-Seq_HL-1_Mouse1.22060960
66CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.20974376
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20935540
68CTCF_26484167_Chip-Seq_Bcells_Mouse1.19225169
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18789497
70SA1_27219007_Chip-Seq_ERYTHROID_Human1.18042455
71HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17939641
72SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.17724561
73CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17027738
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17020484
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16960130
76E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.16783873
77MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16205822
78MYC_22102868_ChIP-Seq_BL_Human1.15943506
79ERG_21242973_ChIP-ChIP_JURKAT_Human1.15335852
80CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15332876
81KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14032728
82SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.13965716
83HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12933662
84SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12456309
85BCOR_27268052_Chip-Seq_Bcells_Human1.09420686
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08951997
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08583567
88FOXP3_21729870_ChIP-Seq_TREG_Human1.06557193
89RARA_24833708_ChIP-Seq_LIVER_Mouse1.04900855
90UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04658290
91RARB_24833708_ChIP-Seq_LIVER_Mouse1.04617664
92E2F7_22180533_ChIP-Seq_HELA_Human1.04197365
93CIITA_25753668_ChIP-Seq_RAJI_Human1.03912966
94SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.02541979
95* PHF8_20622854_ChIP-Seq_HELA_Human1.02232736
96NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01759456
97EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01212383
98TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.01002820
99CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00929817
100NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00857070

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.36186071
2MP0002653_abnormal_ependyma_morphology2.65303599
3MP0005451_abnormal_body_composition2.60493421
4MP0001529_abnormal_vocalization2.57489247
5MP0008260_abnormal_autophagy2.57459086
6MP0005058_abnormal_lysosome_morphology2.49016921
7MP0004859_abnormal_synaptic_plasticity2.43503467
8MP0003123_paternal_imprinting2.26751348
9MP0003186_abnormal_redox_activity2.07540106
10MP0003693_abnormal_embryo_hatching1.95482952
11MP0002736_abnormal_nociception_after1.95256035
12MP0001727_abnormal_embryo_implantation1.93197777
13MP0003122_maternal_imprinting1.89618726
14MP0005501_abnormal_skin_physiology1.89360244
15MP0004858_abnormal_nervous_system1.88594422
16MP0000358_abnormal_cell_content/1.86568000
17MP0001905_abnormal_dopamine_level1.83537849
18MP0005394_taste/olfaction_phenotype1.81492561
19MP0005499_abnormal_olfactory_system1.81492561
20MP0008932_abnormal_embryonic_tissue1.80544119
21MP0004233_abnormal_muscle_weight1.76248107
22MP0003806_abnormal_nucleotide_metabolis1.73460863
23MP0000750_abnormal_muscle_regeneration1.72298247
24MP0006036_abnormal_mitochondrial_physio1.71302832
25MP0000537_abnormal_urethra_morphology1.70848690
26MP0008789_abnormal_olfactory_epithelium1.66613098
27MP0006035_abnormal_mitochondrial_morpho1.63853026
28MP0003111_abnormal_nucleus_morphology1.57223251
29MP0002249_abnormal_larynx_morphology1.57157145
30MP0005623_abnormal_meninges_morphology1.57156573
31MP0000678_abnormal_parathyroid_gland1.56555299
32MP0000049_abnormal_middle_ear1.54396862
33MP0003329_amyloid_beta_deposits1.53406736
34MP0000751_myopathy1.51967309
35MP0003077_abnormal_cell_cycle1.43700983
36MP0002822_catalepsy1.39477050
37MP0000747_muscle_weakness1.37551299
38MP0010094_abnormal_chromosome_stability1.34848053
39MP0000681_abnormal_thyroid_gland1.29627994
40MP0003705_abnormal_hypodermis_morpholog1.29286179
41MP0003942_abnormal_urinary_system1.29195541
42MP0005083_abnormal_biliary_tract1.27220995
43MP0005257_abnormal_intraocular_pressure1.12346237
44MP0004270_analgesia1.11020570
45MP0001849_ear_inflammation1.09699283
46MP0001968_abnormal_touch/_nociception1.07768911
47MP0009379_abnormal_foot_pigmentation1.06020630
48MP0008007_abnormal_cellular_replicative1.01032957
49MP0004133_heterotaxia0.99332100
50MP0000778_abnormal_nervous_system0.96484551
51MP0002098_abnormal_vibrissa_morphology0.96259221
52MP0001346_abnormal_lacrimal_gland0.95935552
53MP0000462_abnormal_digestive_system0.95757166
54MP0004957_abnormal_blastocyst_morpholog0.95284685
55MP0004811_abnormal_neuron_physiology0.92980306
56MP0000566_synostosis0.91089189
57MP0003786_premature_aging0.90146340
58MP0002234_abnormal_pharynx_morphology0.90116903
59MP0002089_abnormal_postnatal_growth/wei0.89633497
60MP0002557_abnormal_social/conspecific_i0.87314684
61MP0009384_cardiac_valve_regurgitation0.85993459
62MP0009672_abnormal_birth_weight0.85897691
63MP0000026_abnormal_inner_ear0.85733668
64MP0008058_abnormal_DNA_repair0.85335676
65MP0003635_abnormal_synaptic_transmissio0.85326706
66MP0003137_abnormal_impulse_conducting0.84927368
67MP0003861_abnormal_nervous_system0.84279921
68MP0002152_abnormal_brain_morphology0.84121959
69MP0002080_prenatal_lethality0.82523587
70MP0005377_hearing/vestibular/ear_phenot0.82125564
71MP0003878_abnormal_ear_physiology0.82125564
72MP0006292_abnormal_olfactory_placode0.81953435
73MP0002572_abnormal_emotion/affect_behav0.81637345
74MP0001730_embryonic_growth_arrest0.81128920
75MP0003011_delayed_dark_adaptation0.81065724
76MP0003634_abnormal_glial_cell0.80965850
77MP0000313_abnormal_cell_death0.80282200
78MP0006276_abnormal_autonomic_nervous0.80114777
79MP0003879_abnormal_hair_cell0.78744368
80MP0009046_muscle_twitch0.78705702
81MP0010771_integument_phenotype0.78413721
82MP0000759_abnormal_skeletal_muscle0.76999668
83MP0009053_abnormal_anal_canal0.76758793
84MP0000343_altered_response_to0.76697793
85MP0005584_abnormal_enzyme/coenzyme_acti0.76213587
86MP0005384_cellular_phenotype0.76143745
87MP0002882_abnormal_neuron_morphology0.75461469
88MP0003121_genomic_imprinting0.74309367
89MP0002063_abnormal_learning/memory/cond0.74268920
90MP0002163_abnormal_gland_morphology0.73867942
91MP0002090_abnormal_vision0.73085243
92MP0005248_abnormal_Harderian_gland0.72484596
93MP0001984_abnormal_olfaction0.71680044
94MP0000955_abnormal_spinal_cord0.71386125
95MP0005330_cardiomyopathy0.70385653
96MP0002909_abnormal_adrenal_gland0.70123279
97MP0000762_abnormal_tongue_morphology0.69548041
98MP0009780_abnormal_chondrocyte_physiolo0.69433444
99MP0002066_abnormal_motor_capabilities/c0.68928116
100MP0003938_abnormal_ear_development0.68834690

Predicted human phenotypes

RankGene SetZ-score
1Abnormal mitochondria in muscle tissue (HP:0008316)4.46330649
2Acute necrotizing encephalopathy (HP:0006965)4.02541574
3Hepatocellular necrosis (HP:0001404)3.93261220
4Decreased activity of mitochondrial respiratory chain (HP:0008972)3.80388170
5Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.80388170
6Mitochondrial inheritance (HP:0001427)3.73579080
7Acute encephalopathy (HP:0006846)3.61929873
8Hepatic necrosis (HP:0002605)3.59951976
9Increased intramyocellular lipid droplets (HP:0012240)3.56564249
10Increased muscle lipid content (HP:0009058)3.36339325
11Increased CSF lactate (HP:0002490)3.33389328
12Hyperacusis (HP:0010780)3.26013476
13Ragged-red muscle fibers (HP:0003200)3.08864250
14Abnormal gallbladder physiology (HP:0012438)3.00316893
15Cholecystitis (HP:0001082)3.00316893
16Progressive macrocephaly (HP:0004481)2.99225104
17Abnormality of glycolysis (HP:0004366)2.82987544
18Hypokinesia (HP:0002375)2.79171055
19Myokymia (HP:0002411)2.76531600
20Hyperthyroidism (HP:0000836)2.68410939
21Insomnia (HP:0100785)2.68243402
22Exercise intolerance (HP:0003546)2.64547564
23Lactic acidosis (HP:0003128)2.60927861
24Overriding aorta (HP:0002623)2.58287665
25Aplasia/Hypoplasia of the sacrum (HP:0008517)2.53966684
26Increased serum lactate (HP:0002151)2.53471572
27Respiratory failure (HP:0002878)2.49102602
28Renal Fanconi syndrome (HP:0001994)2.48057872
29Cerebral edema (HP:0002181)2.46894983
30Testicular atrophy (HP:0000029)2.46034943
31Lipid accumulation in hepatocytes (HP:0006561)2.45450882
32Increased serum pyruvate (HP:0003542)2.45254161
33Distal upper limb amyotrophy (HP:0007149)2.44504765
34Upper limb amyotrophy (HP:0009129)2.44504765
35Hand muscle atrophy (HP:0009130)2.42678159
36Distal lower limb muscle weakness (HP:0009053)2.40688678
37Cerebral hypomyelination (HP:0006808)2.39466159
38Vertebral compression fractures (HP:0002953)2.38619921
39Microretrognathia (HP:0000308)2.37891915
40Increased hepatocellular lipid droplets (HP:0006565)2.37875410
41Opisthotonus (HP:0002179)2.35234279
42Emotional lability (HP:0000712)2.35221089
43Prolonged neonatal jaundice (HP:0006579)2.32308719
44Achilles tendon contracture (HP:0001771)2.31141200
45Elfin facies (HP:0004428)2.30960693
46Rough bone trabeculation (HP:0100670)2.30223295
47Abnormality of cells of the erythroid lineage (HP:0012130)2.29774318
48Progressive muscle weakness (HP:0003323)2.26379463
49Microvesicular hepatic steatosis (HP:0001414)2.25320476
50Abnormal number of erythroid precursors (HP:0012131)2.25237777
51Upper limb muscle weakness (HP:0003484)2.22080307
52Retinal dysplasia (HP:0007973)2.21837383
53Truncus arteriosus (HP:0001660)2.21719091
54Broad distal phalanx of finger (HP:0009836)2.20222188
55Type I transferrin isoform profile (HP:0003642)2.19020443
56Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.14202067
57Abnormal protein N-linked glycosylation (HP:0012347)2.14202067
58Abnormal protein glycosylation (HP:0012346)2.14202067
59Abnormal glycosylation (HP:0012345)2.14202067
60Stridor (HP:0010307)2.12945418
61Pointed chin (HP:0000307)2.01155213
62Shoulder girdle muscle weakness (HP:0003547)2.01144405
63Concave nail (HP:0001598)1.98767367
64Progressive microcephaly (HP:0000253)1.92501016
65Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.92107150
66Abnormality of the Achilles tendon (HP:0005109)1.91717157
67Abnormality of the umbilical cord (HP:0010881)1.90849525
68Trismus (HP:0000211)1.90824697
69Distal lower limb amyotrophy (HP:0008944)1.90332369
70Reticulocytopenia (HP:0001896)1.89680219
71Myopathic facies (HP:0002058)1.89602449
72Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.87573396
73Down-sloping shoulders (HP:0200021)1.86119643
74Hypertensive crisis (HP:0100735)1.85771203
75Hydroureter (HP:0000072)1.85093286
76Abnormality of reticulocytes (HP:0004312)1.83991663
77Reticulocytosis (HP:0001923)1.81297084
78Leukodystrophy (HP:0002415)1.77386962
79Spastic paraparesis (HP:0002313)1.76619189
80Multiple enchondromatosis (HP:0005701)1.76084647
81Postnatal microcephaly (HP:0005484)1.75905232
82Abnormality of glycosphingolipid metabolism (HP:0004343)1.75824530
83Abnormality of glycolipid metabolism (HP:0010969)1.75824530
84Abnormality of liposaccharide metabolism (HP:0010968)1.75824530
85CNS demyelination (HP:0007305)1.75672880
86Fasciculations (HP:0002380)1.75454352
87Dicarboxylic aciduria (HP:0003215)1.75070740
88Abnormality of dicarboxylic acid metabolism (HP:0010995)1.75070740
89Difficulty climbing stairs (HP:0003551)1.74162542
90Hypercalcemia (HP:0003072)1.73063433
91Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.72110961
92Degeneration of anterior horn cells (HP:0002398)1.71424968
93Abnormality of the anterior horn cell (HP:0006802)1.71424968
94Renal duplication (HP:0000075)1.69869312
95Long palpebral fissure (HP:0000637)1.69452838
96Growth hormone excess (HP:0000845)1.68937969
97Cholelithiasis (HP:0001081)1.67745737
98Diminished motivation (HP:0000745)1.67696003
99Centrally nucleated skeletal muscle fibers (HP:0003687)1.67044863
100Hyperparathyroidism (HP:0000843)1.66739264

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.19746923
2TESK13.78715063
3TESK23.66352973
4TRIB33.33330393
5VRK23.16018338
6BCKDK2.96231521
7PIM22.77973359
8EPHA22.75242308
9LIMK12.72649883
10ARAF2.68104930
11SMG12.04099733
12STK161.71359539
13TAOK21.68558756
14PRKD31.66607179
15MAP3K111.66559062
16MAP2K71.58420533
17NME11.58185994
18IRAK31.54771326
19BUB11.53932612
20CSNK1G31.53083652
21PKN21.49515359
22ABL21.40155834
23SIK11.38511215
24AURKA1.37396470
25MUSK1.34160275
26ILK1.33587004
27MAP4K21.30475416
28PAK41.27434531
29EPHB21.26611723
30DAPK11.26062163
31MAPKAPK31.20960688
32CSNK1A1L1.13584720
33CSNK1G21.13130958
34PAK61.12901217
35DAPK31.11117214
36BRAF1.09516081
37LMTK21.07545256
38EIF2AK11.06631231
39RPS6KA41.06599343
40DYRK21.06592768
41PRKCI1.06297822
42SCYL20.98777146
43CAMK2G0.97749425
44RPS6KB20.97030116
45KDR0.96419260
46SIK20.96324912
47PBK0.91999735
48ICK0.91978543
49TLK10.90975267
50SRPK10.90177499
51LRRK20.86228539
52CSNK1G10.84418384
53CDK140.81620375
54CDK190.80799012
55CDK80.79180847
56PRKD20.75741855
57CDK11A0.71061553
58NEK10.70415560
59RPS6KA50.68925834
60AURKB0.67555708
61TRIM280.67430954
62CDC70.67345057
63CDK150.66666109
64CCNB10.66402762
65MAP2K20.65967103
66CDK180.65573635
67VRK10.63508556
68CAMK2B0.63317941
69CDK70.63258959
70PAK10.62856477
71PTK20.61040910
72BMX0.59229143
73MST1R0.58392436
74TTN0.56831207
75EPHA40.56457676
76AKT20.55228558
77CHEK20.55125279
78DYRK1B0.54853777
79PHKG10.53670886
80PHKG20.53670886
81MARK10.53530727
82NTRK10.52529943
83CAMK2D0.52156023
84MAP3K120.51569809
85RPS6KA20.51140043
86MAP3K80.47825752
87PLK10.47562526
88PRPF4B0.46436856
89MINK10.44529157
90BRSK10.42980876
91BCR0.42168953
92TBK10.39687390
93PKN10.38293999
94MYLK0.37947440
95ATR0.37880358
96IRAK20.33693054
97CSNK1A10.32047036
98CAMKK10.31157186
99PRKD10.30151239
100MAP2K40.30146289

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.40477706
2Proteasome_Homo sapiens_hsa030503.37504293
3Oxidative phosphorylation_Homo sapiens_hsa001903.26804794
4Ribosome_Homo sapiens_hsa030102.96843585
5Base excision repair_Homo sapiens_hsa034102.90748132
6Parkinsons disease_Homo sapiens_hsa050122.90581402
7DNA replication_Homo sapiens_hsa030302.69203463
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.49522595
9Biosynthesis of amino acids_Homo sapiens_hsa012302.27665726
10Huntingtons disease_Homo sapiens_hsa050162.22206172
11Pyrimidine metabolism_Homo sapiens_hsa002402.21007026
12RNA polymerase_Homo sapiens_hsa030202.12198457
13Vibrio cholerae infection_Homo sapiens_hsa051102.08844815
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.04770461
15Pentose phosphate pathway_Homo sapiens_hsa000302.02169461
16Mismatch repair_Homo sapiens_hsa034301.88616162
17Alzheimers disease_Homo sapiens_hsa050101.87208703
18Fatty acid elongation_Homo sapiens_hsa000621.84815611
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.81050207
20Carbon metabolism_Homo sapiens_hsa012001.78195859
21Fructose and mannose metabolism_Homo sapiens_hsa000511.74549257
22Synaptic vesicle cycle_Homo sapiens_hsa047211.66508473
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59325699
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.54168114
25Folate biosynthesis_Homo sapiens_hsa007901.48714698
26Galactose metabolism_Homo sapiens_hsa000521.45079026
27Glutathione metabolism_Homo sapiens_hsa004801.40776844
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.38142997
29Cardiac muscle contraction_Homo sapiens_hsa042601.37553256
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33021670
31Spliceosome_Homo sapiens_hsa030401.32185566
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.31600179
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.31550093
34Nucleotide excision repair_Homo sapiens_hsa034201.30670750
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21964173
36Collecting duct acid secretion_Homo sapiens_hsa049661.21592303
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.17184637
38Steroid biosynthesis_Homo sapiens_hsa001001.16560379
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.15301555
40N-Glycan biosynthesis_Homo sapiens_hsa005101.11501936
41Pyruvate metabolism_Homo sapiens_hsa006201.08750452
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06309830
43Phenylalanine metabolism_Homo sapiens_hsa003601.04479324
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03365292
45Homologous recombination_Homo sapiens_hsa034401.02661752
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.01881579
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01252190
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00981318
49Alcoholism_Homo sapiens_hsa050340.98879461
50Vitamin B6 metabolism_Homo sapiens_hsa007500.98845088
51Purine metabolism_Homo sapiens_hsa002300.97655306
52Sulfur metabolism_Homo sapiens_hsa009200.94702120
53Arginine and proline metabolism_Homo sapiens_hsa003300.93469572
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.89425531
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85747567
56Other glycan degradation_Homo sapiens_hsa005110.81888265
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.78855695
58Metabolic pathways_Homo sapiens_hsa011000.76743391
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76426196
60Shigellosis_Homo sapiens_hsa051310.76104027
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75026243
62RNA transport_Homo sapiens_hsa030130.74615186
63Lysosome_Homo sapiens_hsa041420.73691601
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71730478
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70810117
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.70038201
67Fanconi anemia pathway_Homo sapiens_hsa034600.69110018
68Systemic lupus erythematosus_Homo sapiens_hsa053220.66074295
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56194442
70Tyrosine metabolism_Homo sapiens_hsa003500.55741542
71Bladder cancer_Homo sapiens_hsa052190.53202767
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51041099
73Epstein-Barr virus infection_Homo sapiens_hsa051690.49502748
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48478397
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48235996
76Peroxisome_Homo sapiens_hsa041460.46783811
77beta-Alanine metabolism_Homo sapiens_hsa004100.46543150
78Fatty acid metabolism_Homo sapiens_hsa012120.46390129
79Salmonella infection_Homo sapiens_hsa051320.43557108
80Protein export_Homo sapiens_hsa030600.39361586
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38618034
82Endocytosis_Homo sapiens_hsa041440.38486755
83AMPK signaling pathway_Homo sapiens_hsa041520.37904117
84Hippo signaling pathway_Homo sapiens_hsa043900.37626475
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37324365
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35456556
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35029592
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31325361
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31042173
90mRNA surveillance pathway_Homo sapiens_hsa030150.30640646
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29108395
92Notch signaling pathway_Homo sapiens_hsa043300.25741884
93Basal cell carcinoma_Homo sapiens_hsa052170.25143939
94Cell cycle_Homo sapiens_hsa041100.24947881
95Axon guidance_Homo sapiens_hsa043600.24750651
96One carbon pool by folate_Homo sapiens_hsa006700.24706258
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21684105
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.19416820
99Oocyte meiosis_Homo sapiens_hsa041140.18306970
100p53 signaling pathway_Homo sapiens_hsa041150.16892022

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