C7ORF26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.97322281
2positive regulation of gamma-delta T cell activation (GO:0046645)4.52957719
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.43338410
4positive regulation by organism of defense response of other organism involved in symbiotic interact4.43338410
5modulation by symbiont of host immune response (GO:0052553)4.43338410
6positive regulation by symbiont of host defense response (GO:0052509)4.43338410
7modulation by symbiont of host defense response (GO:0052031)4.43338410
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.43338410
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.25348443
10negative regulation of cell killing (GO:0031342)4.25348443
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.95105550
12response to peptidoglycan (GO:0032494)3.87864329
13antigen processing and presentation of endogenous antigen (GO:0019883)3.81113368
14mannose metabolic process (GO:0006013)3.74798138
15response to muramyl dipeptide (GO:0032495)3.73973915
16modulation by virus of host process (GO:0019054)3.71102973
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.67582271
18leukocyte aggregation (GO:0070486)3.65768642
19positive thymic T cell selection (GO:0045059)3.60640617
20modulation by symbiont of host cellular process (GO:0044068)3.58796641
21macrophage activation involved in immune response (GO:0002281)3.53576944
223-UTR-mediated mRNA stabilization (GO:0070935)3.39422664
23regulation of gamma-delta T cell activation (GO:0046643)3.39354660
24detection of bacterium (GO:0016045)3.39138333
25detection of other organism (GO:0098543)3.33942453
26NIK/NF-kappaB signaling (GO:0038061)3.33868349
27regulation of interferon-beta biosynthetic process (GO:0045357)3.33289079
28thymic T cell selection (GO:0045061)3.31088242
29positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.24483491
30regulation of gamma-delta T cell differentiation (GO:0045586)3.21918216
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.18600705
32ribosomal small subunit biogenesis (GO:0042274)3.15039944
33negative regulation of phagocytosis (GO:0050765)3.01849460
34positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.01226405
35response to laminar fluid shear stress (GO:0034616)3.01015667
36apoptotic process involved in morphogenesis (GO:0060561)2.99315339
37T cell selection (GO:0045058)2.91641100
38negative regulation of granulocyte differentiation (GO:0030853)2.87528417
39regulation of leukocyte degranulation (GO:0043300)2.86709998
40regulation of type I interferon-mediated signaling pathway (GO:0060338)2.86373198
41regulation of mammary gland epithelial cell proliferation (GO:0033599)2.85838007
42positive regulation of B cell differentiation (GO:0045579)2.85674712
43negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.83738852
44tolerance induction (GO:0002507)2.82675946
45neutrophil activation involved in immune response (GO:0002283)2.82239271
46B cell receptor signaling pathway (GO:0050853)2.81042593
47response to host (GO:0075136)2.79009707
48response to host defenses (GO:0052200)2.79009707
49response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.79009707
50negative regulation of interleukin-12 production (GO:0032695)2.78273388
51cellular extravasation (GO:0045123)2.77752692
52response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.77697111
53response to host immune response (GO:0052572)2.77697111
54viral transcription (GO:0019083)2.76695830
55positive regulation of Cdc42 GTPase activity (GO:0043089)2.74908864
56immunoglobulin mediated immune response (GO:0016064)2.74587333
57positive T cell selection (GO:0043368)2.73254235
58stress fiber assembly (GO:0043149)2.69576337
59regulation of defense response to virus by virus (GO:0050690)2.69352111
60epithelial cell differentiation involved in prostate gland development (GO:0060742)2.69065423
61regulation of mast cell degranulation (GO:0043304)2.68458200
62negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.67518114
63intracellular estrogen receptor signaling pathway (GO:0030520)2.67415279
64negative regulation of cAMP-mediated signaling (GO:0043951)2.66133797
65negative thymic T cell selection (GO:0045060)2.65753300
66positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.64543849
67germinal center formation (GO:0002467)2.63672369
68regulation of early endosome to late endosome transport (GO:2000641)2.63302843
69regulation of myeloid leukocyte mediated immunity (GO:0002886)2.62711591
70negative regulation of glial cell proliferation (GO:0060253)2.61234897
71detection of external biotic stimulus (GO:0098581)2.59155014
72cellular response to virus (GO:0098586)2.58474437
73negative regulation of viral release from host cell (GO:1902187)2.57655884
74activation of MAPKKK activity (GO:0000185)2.57362420
75regulation of granulocyte differentiation (GO:0030852)2.56699679
76regulation of chromatin binding (GO:0035561)2.56276456
77lipopolysaccharide-mediated signaling pathway (GO:0031663)2.55758052
78Peyers patch development (GO:0048541)2.55001748
79mucosal-associated lymphoid tissue development (GO:0048537)2.55001748
80regulation of monocyte differentiation (GO:0045655)2.54225834
81pentose-phosphate shunt (GO:0006098)2.53766983
82respiratory burst (GO:0045730)2.52311532
83positive regulation of histone deacetylation (GO:0031065)2.50989295
84embryonic process involved in female pregnancy (GO:0060136)2.50659862
85histone H4 deacetylation (GO:0070933)2.50463938
86negative regulation of toll-like receptor signaling pathway (GO:0034122)2.50327838
87negative regulation of innate immune response (GO:0045824)2.48993151
88regulation of B cell receptor signaling pathway (GO:0050855)2.46878743
89negative T cell selection (GO:0043383)2.46843133
90negative regulation of interleukin-6 production (GO:0032715)2.44340937
91modulation by virus of host morphology or physiology (GO:0019048)2.43396076
92T cell homeostasis (GO:0043029)2.41874255
93negative regulation of cell size (GO:0045792)2.40645475
94signal complex assembly (GO:0007172)2.37370433
95translational termination (GO:0006415)2.36488323
96negative regulation of leukocyte mediated immunity (GO:0002704)2.36343072
97negative regulation of interleukin-8 production (GO:0032717)2.36318709
98positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.36199241
99regulation of NFAT protein import into nucleus (GO:0051532)2.36150639
100pinocytosis (GO:0006907)2.35961930

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.62045891
2MYC_22102868_ChIP-Seq_BL_Human3.31662734
3KDM2B_26808549_Chip-Seq_SUP-B15_Human2.64747544
4LXR_22292898_ChIP-Seq_THP-1_Human2.60512899
5KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.53159125
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.51108058
7TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.45648432
8ELK3_25401928_ChIP-Seq_HUVEC_Human2.42029001
9TCF7_22412390_ChIP-Seq_EML_Mouse2.34287698
10KDM2B_26808549_Chip-Seq_DND41_Human2.34209259
11VDR_24763502_ChIP-Seq_THP-1_Human2.27549967
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.22165268
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.17886143
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.00046519
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.99907612
16EGR1_19374776_ChIP-ChIP_THP-1_Human1.95792502
17MAF_26560356_Chip-Seq_TH1_Human1.91901568
18TP63_17297297_ChIP-ChIP_HaCaT_Human1.90941559
19KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.89859698
20RACK7_27058665_Chip-Seq_MCF-7_Human1.85281462
21UTX_26944678_Chip-Seq_JUKART_Human1.82720963
22E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.81469852
23MAF_26560356_Chip-Seq_TH2_Human1.79910916
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.75686162
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.70853630
26KDM2B_26808549_Chip-Seq_K562_Human1.66406424
27RUNX1_22412390_ChIP-Seq_EML_Mouse1.66251855
28P68_20966046_ChIP-Seq_HELA_Human1.66225612
29TET1_21451524_ChIP-Seq_MESCs_Mouse1.65717640
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.63862511
31KDM2B_26808549_Chip-Seq_JURKAT_Human1.63472388
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.60214012
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.59545381
34SRY_22984422_ChIP-ChIP_TESTIS_Rat1.55734529
35CTCF_27219007_Chip-Seq_ERYTHROID_Human1.54269167
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.53563569
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52738517
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52674854
39* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.48737675
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.47168937
41SA1_27219007_Chip-Seq_ERYTHROID_Human1.46894125
42ELF1_20517297_ChIP-Seq_JURKAT_Human1.45852746
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43572297
44SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41717076
45TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.40084250
46* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39023930
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.37428667
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37216388
49ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36107806
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34702113
51BCOR_27268052_Chip-Seq_Bcells_Human1.30471211
52GATA1_22383799_ChIP-Seq_G1ME_Mouse1.30450597
53PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29984488
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29734797
55UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29521517
56SMC4_20622854_ChIP-Seq_HELA_Human1.28140893
57BCL6_27268052_Chip-Seq_Bcells_Human1.28016066
58GATA1_19941827_ChIP-Seq_MEL_Mouse1.27151745
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27015700
60SCL_19346495_ChIP-Seq_HPC-7_Human1.26616826
61MYB_21317192_ChIP-Seq_ERMYB_Mouse1.25790283
62NCOR1_26117541_ChIP-Seq_K562_Human1.24891314
63CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24661648
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.23005664
65PU.1_20513432_ChIP-Seq_Bcells_Mouse1.22951060
66ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19242574
67SPI1_23127762_ChIP-Seq_K562_Human1.18592873
68STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17704971
69CREB1_26743006_Chip-Seq_LNCaP_Human1.17679510
70SPI1_23547873_ChIP-Seq_NB4_Human1.17344630
71ERG_21242973_ChIP-ChIP_JURKAT_Human1.17321581
72SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16960325
73DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14545897
74CIITA_25753668_ChIP-Seq_RAJI_Human1.14026073
75CTCF_26484167_Chip-Seq_Bcells_Mouse1.13797952
76SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13232915
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13152613
78CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12759430
79SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12594226
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12462582
81STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.11528975
82CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11512820
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09428519
84STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08274092
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08023426
86SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07987185
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06736641
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05652982
89CTCF_21964334_Chip-Seq_Bcells_Human1.05323603
90CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05041266
91KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04798082
92RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04551151
93PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04394965
94P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04351838
95GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03670281
96CTCF_21964334_ChIP-Seq_BJAB-B_Human1.03192381
97CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02686265
98KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02308083
99KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01036983
100CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00122579

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.25578750
2MP0003436_decreased_susceptibility_to3.67990681
3MP0005058_abnormal_lysosome_morphology3.06697861
4MP0009278_abnormal_bone_marrow3.00519052
5MP0003172_abnormal_lysosome_physiology2.69071217
6MP0008260_abnormal_autophagy2.62017989
7MP0003763_abnormal_thymus_physiology2.47361757
8MP0003705_abnormal_hypodermis_morpholog2.41186971
9MP0009333_abnormal_splenocyte_physiolog2.26466778
10MP0005451_abnormal_body_composition2.26065613
11MP0003300_gastrointestinal_ulcer2.19768843
12MP0005025_abnormal_response_to2.14565134
13MP0002419_abnormal_innate_immunity2.14153260
14MP0003724_increased_susceptibility_to2.09094117
15MP0005000_abnormal_immune_tolerance2.03468753
16MP0004185_abnormal_adipocyte_glucose2.02402332
17MP0001800_abnormal_humoral_immune2.02177807
18MP0003191_abnormal_cellular_cholesterol2.01856771
19MP0001835_abnormal_antigen_presentation1.95855299
20MP0009840_abnormal_foam_cell1.95272842
21MP0000685_abnormal_immune_system1.94475639
22MP0005387_immune_system_phenotype1.90501785
23MP0001790_abnormal_immune_system1.90501785
24MP0005076_abnormal_cell_differentiation1.89758337
25MP0002420_abnormal_adaptive_immunity1.88340552
26MP0001819_abnormal_immune_cell1.85979608
27MP0002723_abnormal_immune_serum1.81343538
28MP0002398_abnormal_bone_marrow1.77037718
29MP0002452_abnormal_antigen_presenting1.76461988
30MP0005397_hematopoietic_system_phenotyp1.72338628
31MP0001545_abnormal_hematopoietic_system1.72338628
32MP0004947_skin_inflammation1.71798633
33MP0001849_ear_inflammation1.70512086
34MP0005464_abnormal_platelet_physiology1.70211748
35MP0000703_abnormal_thymus_morphology1.66869531
36MP0002396_abnormal_hematopoietic_system1.66386615
37MP0001533_abnormal_skeleton_physiology1.66144946
38MP0003183_abnormal_peptide_metabolism1.61691465
39MP0002405_respiratory_system_inflammati1.60979902
40MP0000716_abnormal_immune_system1.57944612
41MP0005409_darkened_coat_color1.54696189
42MP0004381_abnormal_hair_follicle1.50335487
43MP0005666_abnormal_adipose_tissue1.41796156
44MP0001873_stomach_inflammation1.40922186
45MP0004510_myositis1.39549938
46MP0004858_abnormal_nervous_system1.39467932
47MP0002429_abnormal_blood_cell1.39447239
48MP0000858_altered_metastatic_potential1.39425525
49MP0002722_abnormal_immune_system1.38102702
50MP0000678_abnormal_parathyroid_gland1.34711748
51MP0004808_abnormal_hematopoietic_stem1.33935506
52MP0010155_abnormal_intestine_physiology1.33571100
53MP0003453_abnormal_keratinocyte_physiol1.30136155
54MP0003123_paternal_imprinting1.30041726
55MP0005671_abnormal_response_to1.28683543
56MP0000689_abnormal_spleen_morphology1.25746698
57MP0009785_altered_susceptibility_to1.23866193
58MP0002132_abnormal_respiratory_system1.23667567
59MP0000490_abnormal_crypts_of1.20636411
60MP0003828_pulmonary_edema1.20580620
61MP0000465_gastrointestinal_hemorrhage1.18460875
62MP0001851_eye_inflammation1.18298298
63MP0009379_abnormal_foot_pigmentation1.18080770
64MP0002148_abnormal_hypersensitivity_rea1.17414161
65MP0005310_abnormal_salivary_gland1.15936015
66MP0002998_abnormal_bone_remodeling1.12079666
67MP0001845_abnormal_inflammatory_respons1.08864208
68MP0003091_abnormal_cell_migration1.08095078
69MP0006082_CNS_inflammation1.07035188
70MP0002877_abnormal_melanocyte_morpholog1.06895888
71MP0003866_abnormal_defecation1.06389618
72MP0001663_abnormal_digestive_system1.05821079
73MP0001853_heart_inflammation1.00455381
74MP0005390_skeleton_phenotype0.99146489
75MP0003075_altered_response_to0.99114777
76MP0000015_abnormal_ear_pigmentation0.97137928
77MP0005375_adipose_tissue_phenotype0.95992358
78MP0004233_abnormal_muscle_weight0.93848440
79MP0003279_aneurysm0.89280578
80MP0008469_abnormal_protein_level0.87472660
81MP0005381_digestive/alimentary_phenotyp0.86122234
82MP0003566_abnormal_cell_adhesion0.86075737
83MP0004130_abnormal_muscle_cell0.85668759
84MP0003329_amyloid_beta_deposits0.85258019
85MP0001348_abnormal_lacrimal_gland0.84253458
86MP0002796_impaired_skin_barrier0.81470543
87MP0003448_altered_tumor_morphology0.80667215
88MP0009931_abnormal_skin_appearance0.80074825
89MP0000604_amyloidosis0.76930456
90MP0005075_abnormal_melanosome_morpholog0.74793458
91MP0002089_abnormal_postnatal_growth/wei0.74415991
92MP0000733_abnormal_muscle_development0.72322408
93MP0002138_abnormal_hepatobiliary_system0.71085834
94MP0002249_abnormal_larynx_morphology0.70715143
95MP0003656_abnormal_erythrocyte_physiolo0.68593965
96MP0002933_joint_inflammation0.67114228
97MP0005501_abnormal_skin_physiology0.66397864
98MP0005621_abnormal_cell_physiology0.65903793
99MP0000681_abnormal_thyroid_gland0.65666665
100MP0009115_abnormal_fat_cell0.63757816

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.67595899
2Cellulitis (HP:0100658)3.64675335
3Abnormality of macrophages (HP:0004311)3.33637512
4Recurrent abscess formation (HP:0002722)3.32918049
5Recurrent bacterial skin infections (HP:0005406)3.31392940
6Obstructive lung disease (HP:0006536)3.27592300
7Chronic obstructive pulmonary disease (HP:0006510)3.27592300
8Increased IgE level (HP:0003212)2.95734699
9Mediastinal lymphadenopathy (HP:0100721)2.70679087
10Meningitis (HP:0001287)2.67560730
11Gastrointestinal inflammation (HP:0004386)2.59620806
12Colitis (HP:0002583)2.58691322
13Recurrent gram-negative bacterial infections (HP:0005420)2.58037547
14Gingivitis (HP:0000230)2.57087045
15Elevated erythrocyte sedimentation rate (HP:0003565)2.52717847
16Recurrent fungal infections (HP:0002841)2.52219214
17Agammaglobulinemia (HP:0004432)2.49453732
18Obstructive sleep apnea (HP:0002870)2.47495015
19Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.47337380
20Hypertensive crisis (HP:0100735)2.45078225
21Myositis (HP:0100614)2.39845379
22Gastrointestinal stroma tumor (HP:0100723)2.38819340
23Dysostosis multiplex (HP:0000943)2.37823893
24Recurrent viral infections (HP:0004429)2.37165577
25Purpura (HP:0000979)2.35308039
26Prolonged bleeding time (HP:0003010)2.31812994
27Polygenic inheritance (HP:0010982)2.31599698
28Hyperacusis (HP:0010780)2.28325337
29Increased cerebral lipofuscin (HP:0011813)2.26720961
30Inflammation of the large intestine (HP:0002037)2.26306644
31Deep palmar crease (HP:0006191)2.26127771
32Increased serum ferritin (HP:0003281)2.24190503
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.20334357
34Panhypogammaglobulinemia (HP:0003139)2.19116285
35Spontaneous hematomas (HP:0007420)2.18912696
36Neonatal hypoglycemia (HP:0001998)2.18655030
37Hypercortisolism (HP:0001578)2.17262368
38Vertebral compression fractures (HP:0002953)2.15564895
39Abnormality of the fingertips (HP:0001211)2.15072973
40Abnormality of the thoracic spine (HP:0100711)2.14874741
41Broad face (HP:0000283)2.14455318
42Annular pancreas (HP:0001734)2.14206228
43Thoracic kyphosis (HP:0002942)2.12665189
44Disproportionate tall stature (HP:0001519)2.08072585
45Loss of speech (HP:0002371)2.06990605
46Segmental peripheral demyelination/remyelination (HP:0003481)2.06899912
47Petechiae (HP:0000967)2.06569055
48Vasculitis (HP:0002633)2.06269091
49Hypochromic anemia (HP:0001931)2.04693918
50Slow saccadic eye movements (HP:0000514)2.03967411
51Gastrointestinal infarctions (HP:0005244)2.03656723
52Thin bony cortex (HP:0002753)2.03178164
53Long palpebral fissure (HP:0000637)2.03064204
54Abnormality of the nasal mucosa (HP:0000433)2.02474921
55Recurrent skin infections (HP:0001581)2.00700585
56Nasal polyposis (HP:0100582)2.00089043
57Seborrheic dermatitis (HP:0001051)1.98267518
58Mitral regurgitation (HP:0001653)1.97350621
59Orchitis (HP:0100796)1.96235537
60Papilloma (HP:0012740)1.96125054
61Verrucae (HP:0200043)1.96125054
62Urticaria (HP:0001025)1.95961831
63Hemorrhage of the eye (HP:0011885)1.95637438
64Anomalous pulmonary venous return (HP:0010772)1.94827973
65Hyperthyroidism (HP:0000836)1.93232993
66Truncus arteriosus (HP:0001660)1.93085375
67Increased neuronal autofluorescent lipopigment (HP:0002074)1.92348635
68Osteomyelitis (HP:0002754)1.92247069
69Peripheral hypomyelination (HP:0007182)1.91037759
70Viral hepatitis (HP:0006562)1.90371475
71Easy fatigability (HP:0003388)1.90164105
72Emphysema (HP:0002097)1.89243994
73Abnormality of cells of the erythroid lineage (HP:0012130)1.88241056
74Abnormality of the pulmonary veins (HP:0011718)1.88181054
75Epistaxis (HP:0000421)1.86298891
76Pustule (HP:0200039)1.86053833
77Lymphopenia (HP:0001888)1.85507357
78Metaphyseal cupping (HP:0003021)1.85010036
79Supranuclear gaze palsy (HP:0000605)1.84060668
80Chronic mucocutaneous candidiasis (HP:0002728)1.82848698
81Recurrent cutaneous fungal infections (HP:0011370)1.82848698
82Microvesicular hepatic steatosis (HP:0001414)1.81738562
83Chest pain (HP:0100749)1.80126083
84Centrally nucleated skeletal muscle fibers (HP:0003687)1.80047116
85Achilles tendon contracture (HP:0001771)1.79727334
86Atelectasis (HP:0100750)1.78674557
87Abnormality of liposaccharide metabolism (HP:0010968)1.77390565
88Abnormality of glycosphingolipid metabolism (HP:0004343)1.77390565
89Abnormality of glycolipid metabolism (HP:0010969)1.77390565
90Amyloidosis (HP:0011034)1.77124680
91Thrombocytosis (HP:0001894)1.76900610
92Hypergammaglobulinemia (HP:0010702)1.76899755
93Restrictive lung disease (HP:0002091)1.76872858
94Increased variability in muscle fiber diameter (HP:0003557)1.76461463
95Sepsis (HP:0100806)1.76118838
96Neuronal loss in central nervous system (HP:0002529)1.74606866
97Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.74414190
98Hyperparathyroidism (HP:0000843)1.74218452
99Polycythemia (HP:0001901)1.73495925
100Abnormality of cells of the lymphoid lineage (HP:0012140)1.71922899

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.33382002
2PRPF4B3.63134456
3ERN13.44729431
4SMG13.07478201
5MAP4K12.61390486
6ICK2.57624222
7SIK12.48572744
8MAP2K32.07401436
9MAP3K102.03394719
10RIPK41.99461832
11IRAK31.95499281
12CDK121.93920208
13NME21.92100716
14TYK21.75731513
15IRAK41.74001163
16TESK21.69740463
17MAP3K131.61128597
18MAP3K111.56941087
19MARK21.42905617
20TAOK11.41174072
21ZAP701.40886167
22ARAF1.39863149
23TNK21.36273529
24EEF2K1.32089260
25TAOK21.31348322
26SIK21.27827651
27BLK1.26912574
28PKN21.25928346
29CSK1.25074161
30FES1.24650430
31FGFR41.22017416
32GRK61.21563489
33TBK11.17334101
34PRKD21.15294074
35EPHB11.13376192
36RIPK11.12661463
37MAP3K11.11689456
38BTK1.11451739
39JAK31.09842698
40MAP3K31.06163800
41LRRK21.05017428
42RPS6KC11.04167357
43RPS6KL11.04167357
44KSR20.98851715
45TESK10.96603302
46HIPK20.92365253
47CDC42BPA0.92343261
48MAP2K20.90789995
49PIM20.89766835
50SIK30.89693371
51PTK60.89646131
52RPS6KA20.88654498
53MAP3K140.87532771
54BRAF0.86737377
55TTN0.86519616
56HCK0.85177872
57RPS6KA60.83041789
58IRAK20.83006734
59MTOR0.81132007
60CDK40.78232619
61PDPK10.76904063
62TYRO30.75242786
63MAPK120.70156357
64MAPK110.69558663
65DYRK1B0.65891150
66MARK30.65154380
67MAP3K80.64026145
68SYK0.63864804
69IKBKB0.61932658
70RET0.60702813
71IKBKE0.58916994
72PDK10.56706184
73CSF1R0.56608685
74CAMKK10.56534416
75LCK0.55701336
76PRKD30.55062190
77BMX0.54728544
78MAPK70.54035150
79MAPK40.50553596
80CDK90.50384289
81MOS0.48665917
82LYN0.48535624
83JAK10.47375664
84MAP3K90.47363001
85MAP3K70.46164350
86JAK20.44267096
87PDGFRA0.43820769
88CDK70.42936404
89MATK0.41035593
90RPS6KA10.39879232
91RAF10.37246800
92FGFR30.37153832
93MAPKAPK20.37007970
94FGR0.36762634
95MAP3K60.36306047
96STK380.34266315
97PIM10.34141930
98STK100.33435587
99ABL20.32855503
100RPS6KB20.31453676

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.67327076
2Acute myeloid leukemia_Homo sapiens_hsa052212.59243889
3B cell receptor signaling pathway_Homo sapiens_hsa046622.45538305
4Osteoclast differentiation_Homo sapiens_hsa043802.23447578
5Notch signaling pathway_Homo sapiens_hsa043302.18286191
6Chronic myeloid leukemia_Homo sapiens_hsa052202.07544522
7Non-small cell lung cancer_Homo sapiens_hsa052232.01128833
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.97004403
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.90489828
10Leishmaniasis_Homo sapiens_hsa051401.81961351
11VEGF signaling pathway_Homo sapiens_hsa043701.80781781
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.74324849
13Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.73270784
14Endometrial cancer_Homo sapiens_hsa052131.60357026
15Pancreatic cancer_Homo sapiens_hsa052121.60324690
16Primary immunodeficiency_Homo sapiens_hsa053401.59822302
17T cell receptor signaling pathway_Homo sapiens_hsa046601.46581091
18Hepatitis B_Homo sapiens_hsa051611.41925363
19Neurotrophin signaling pathway_Homo sapiens_hsa047221.36698882
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.33907098
21Renal cell carcinoma_Homo sapiens_hsa052111.32067545
22Tuberculosis_Homo sapiens_hsa051521.29710465
23Bladder cancer_Homo sapiens_hsa052191.28636594
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.28535857
25Measles_Homo sapiens_hsa051621.25295641
26Influenza A_Homo sapiens_hsa051641.24034490
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.22712873
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.22299359
29Colorectal cancer_Homo sapiens_hsa052101.21914020
30mTOR signaling pathway_Homo sapiens_hsa041501.21899082
31Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.20076528
32Toxoplasmosis_Homo sapiens_hsa051451.19397692
33Herpes simplex infection_Homo sapiens_hsa051681.18837943
34Hepatitis C_Homo sapiens_hsa051601.18666971
35Sulfur relay system_Homo sapiens_hsa041221.18657715
36Thyroid cancer_Homo sapiens_hsa052161.17454639
37TNF signaling pathway_Homo sapiens_hsa046681.15582573
38Staphylococcus aureus infection_Homo sapiens_hsa051501.13420218
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09735426
40ErbB signaling pathway_Homo sapiens_hsa040121.09264690
41Chemokine signaling pathway_Homo sapiens_hsa040621.09198717
42Viral myocarditis_Homo sapiens_hsa054161.08651444
43Apoptosis_Homo sapiens_hsa042101.07223297
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.06923493
45Prolactin signaling pathway_Homo sapiens_hsa049171.06286461
46Prion diseases_Homo sapiens_hsa050201.06038163
47Phospholipase D signaling pathway_Homo sapiens_hsa040721.04799096
48Malaria_Homo sapiens_hsa051441.02175584
49Leukocyte transendothelial migration_Homo sapiens_hsa046701.01722974
50HTLV-I infection_Homo sapiens_hsa051661.00134758
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98181024
52Allograft rejection_Homo sapiens_hsa053300.95898458
53Viral carcinogenesis_Homo sapiens_hsa052030.95573057
54Lysosome_Homo sapiens_hsa041420.95154261
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93912058
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.93134078
57Glioma_Homo sapiens_hsa052140.92873375
58Autoimmune thyroid disease_Homo sapiens_hsa053200.92653330
59Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92003115
60Ribosome_Homo sapiens_hsa030100.91946352
61Prostate cancer_Homo sapiens_hsa052150.91730087
62Shigellosis_Homo sapiens_hsa051310.91083856
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.91059516
64Insulin signaling pathway_Homo sapiens_hsa049100.89462160
65Pentose phosphate pathway_Homo sapiens_hsa000300.89411140
66Graft-versus-host disease_Homo sapiens_hsa053320.88911034
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.88499611
68FoxO signaling pathway_Homo sapiens_hsa040680.86682171
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.86607562
70Epstein-Barr virus infection_Homo sapiens_hsa051690.86051772
71Hematopoietic cell lineage_Homo sapiens_hsa046400.85992814
72Inositol phosphate metabolism_Homo sapiens_hsa005620.85807572
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85255841
74Endocytosis_Homo sapiens_hsa041440.85053905
75Choline metabolism in cancer_Homo sapiens_hsa052310.83730722
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80239564
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.79250020
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77848573
79Platelet activation_Homo sapiens_hsa046110.77807585
80Small cell lung cancer_Homo sapiens_hsa052220.72729858
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72357187
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70469307
83Antigen processing and presentation_Homo sapiens_hsa046120.68590066
84Phagosome_Homo sapiens_hsa041450.68321382
85MAPK signaling pathway_Homo sapiens_hsa040100.67792105
86Insulin resistance_Homo sapiens_hsa049310.65785473
87GnRH signaling pathway_Homo sapiens_hsa049120.64666187
88Salmonella infection_Homo sapiens_hsa051320.63573062
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.63266474
90Amoebiasis_Homo sapiens_hsa051460.62115071
91Estrogen signaling pathway_Homo sapiens_hsa049150.61501164
92Base excision repair_Homo sapiens_hsa034100.61368986
93AMPK signaling pathway_Homo sapiens_hsa041520.59855468
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58088191
95HIF-1 signaling pathway_Homo sapiens_hsa040660.56721842
96Pertussis_Homo sapiens_hsa051330.54251553
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53313903
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50899147
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50789845
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49770200

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