C6ORF89

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)4.84826813
2Golgi transport vesicle coating (GO:0048200)4.84826813
3protein localization to endosome (GO:0036010)3.89810046
4retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.55813111
5skin morphogenesis (GO:0043589)3.53219895
6negative regulation of erythrocyte differentiation (GO:0045647)3.46161066
7regulation of early endosome to late endosome transport (GO:2000641)3.33200640
8regulation of extracellular matrix disassembly (GO:0010715)3.27228676
9barbed-end actin filament capping (GO:0051016)3.24762438
10cytoskeletal anchoring at plasma membrane (GO:0007016)3.22244194
11protein retention in ER lumen (GO:0006621)3.22065345
12maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.13310823
13vesicle coating (GO:0006901)3.06896653
14positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.93483204
15iron ion import (GO:0097286)2.86522853
16positive regulation of receptor recycling (GO:0001921)2.85793266
17positive regulation of extracellular matrix organization (GO:1903055)2.85668941
18negative regulation of fatty acid transport (GO:2000192)2.82672196
19extracellular fibril organization (GO:0043206)2.81625982
20hypotonic response (GO:0006971)2.79433869
21macroautophagy (GO:0016236)2.79116301
22negative regulation of protein localization to plasma membrane (GO:1903077)2.77603579
23cell adhesion mediated by integrin (GO:0033627)2.77347189
24stress fiber assembly (GO:0043149)2.73706549
25fibril organization (GO:0097435)2.70400223
26type B pancreatic cell proliferation (GO:0044342)2.68959577
27cell-substrate junction assembly (GO:0007044)2.68004013
28regulation of ARF protein signal transduction (GO:0032012)2.67427736
29protein targeting to plasma membrane (GO:0072661)2.65619897
30mannose metabolic process (GO:0006013)2.64656251
31COPII vesicle coating (GO:0048208)2.60864104
32negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.60658114
33extracellular matrix assembly (GO:0085029)2.59269814
34regulation of glucose import in response to insulin stimulus (GO:2001273)2.58198117
35activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.57498815
36cortical actin cytoskeleton organization (GO:0030866)2.57082783
37focal adhesion assembly (GO:0048041)2.53761512
38cell-substrate adherens junction assembly (GO:0007045)2.53761512
39peptidyl-proline hydroxylation (GO:0019511)2.52970016
40regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.51617261
41basement membrane organization (GO:0071711)2.51301210
42positive regulation of blood vessel endothelial cell migration (GO:0043536)2.49633960
43apoptotic cell clearance (GO:0043277)2.48013400
44collagen fibril organization (GO:0030199)2.46769736
45adherens junction assembly (GO:0034333)2.45641520
46regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.42368010
47positive regulation of nuclease activity (GO:0032075)2.39980256
48regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.39539162
49protein hydroxylation (GO:0018126)2.39469393
50protoporphyrinogen IX metabolic process (GO:0046501)2.38289667
51insulin-like growth factor receptor signaling pathway (GO:0048009)2.35566691
52regulation of extracellular matrix organization (GO:1903053)2.34912590
53response to laminar fluid shear stress (GO:0034616)2.34600870
54positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.34236003
55adhesion of symbiont to host (GO:0044406)2.34180917
56regulation of cholesterol biosynthetic process (GO:0045540)2.31328458
57actin filament depolymerization (GO:0030042)2.29851994
58cellular response to monoamine stimulus (GO:0071868)2.29185057
59cellular response to catecholamine stimulus (GO:0071870)2.29185057
60positive regulation of osteoblast proliferation (GO:0033690)2.28843572
61import into cell (GO:0098657)2.28431855
62endoplasmic reticulum unfolded protein response (GO:0030968)2.27546856
63cortical cytoskeleton organization (GO:0030865)2.26737800
64low-density lipoprotein particle clearance (GO:0034383)2.25114734
65gas transport (GO:0015669)2.25064459
66alpha-linolenic acid metabolic process (GO:0036109)2.24151430
67response to thyroid hormone (GO:0097066)2.22917694
68cellular response to epinephrine stimulus (GO:0071872)2.22573602
69regulation of cholesterol homeostasis (GO:2000188)2.21916719
70positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.20877588
71regulation of amyloid precursor protein catabolic process (GO:1902991)2.19444575
72ER-nucleus signaling pathway (GO:0006984)2.18006879
73positive regulation of protein dephosphorylation (GO:0035307)2.17953585
74cellular response to thyroid hormone stimulus (GO:0097067)2.17536255
75desmosome organization (GO:0002934)2.16277756
76negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.15748640
77cell volume homeostasis (GO:0006884)2.15663324
78sodium ion export (GO:0071436)2.14417740
79virion attachment to host cell (GO:0019062)2.13533854
80adhesion of symbiont to host cell (GO:0044650)2.13533854
81vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.13432788
82cellular response to unfolded protein (GO:0034620)2.12447368
83protein heterotrimerization (GO:0070208)2.12053324
84negative regulation of cell size (GO:0045792)2.09033140
85regulation of response to osmotic stress (GO:0047484)2.08891980
86negative regulation of anoikis (GO:2000811)2.06474369
87vascular endothelial growth factor signaling pathway (GO:0038084)2.04911004
88surfactant homeostasis (GO:0043129)2.03305103
89endodermal cell differentiation (GO:0035987)2.02319581
90venous blood vessel morphogenesis (GO:0048845)2.02073329
91positive regulation of myotube differentiation (GO:0010831)2.00792410
92regulation of cholesterol metabolic process (GO:0090181)1.99792381
93negative regulation of potassium ion transmembrane transport (GO:1901380)1.99771980
94hyaluronan catabolic process (GO:0030214)1.99746841
95regulation of nuclease activity (GO:0032069)1.99736802
96hemoglobin metabolic process (GO:0020027)1.99379869
97hemidesmosome assembly (GO:0031581)1.97965596
98negative regulation of complement activation (GO:0045916)1.97814350
99collagen metabolic process (GO:0032963)1.97440608
100cell communication by electrical coupling involved in cardiac conduction (GO:0086064)1.96865424

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.29400995
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.09335302
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.92015092
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.69218364
5CLOCK_20551151_ChIP-Seq_293T_Human2.60054351
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.51517195
7ELK3_25401928_ChIP-Seq_HUVEC_Human2.22565939
8TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.13300980
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.12184941
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.10749835
11LXR_22292898_ChIP-Seq_THP-1_Human2.08081713
12RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.05258822
13* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.05020539
14GATA1_19941826_ChIP-Seq_K562_Human2.03052625
15KDM2B_26808549_Chip-Seq_SUP-B15_Human2.02631043
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.97421870
17ESR2_21235772_ChIP-Seq_MCF-7_Human1.89602891
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88837270
19CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.87024889
20RACK7_27058665_Chip-Seq_MCF-7_Human1.81778363
21KDM2B_26808549_Chip-Seq_K562_Human1.80368777
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.80151105
23WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.79756533
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.72584798
25P300_27058665_Chip-Seq_ZR-75-30cells_Human1.71298906
26TBX20_22080862_ChIP-Seq_HEART_Mouse1.71222119
27TBX20_22328084_ChIP-Seq_HEART_Mouse1.71222119
28KDM2B_26808549_Chip-Seq_DND41_Human1.62857215
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.62818625
30KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.62320165
31GATA1_22025678_ChIP-Seq_K562_Human1.62084125
32RXR_22158963_ChIP-Seq_LIVER_Mouse1.61967295
33TCF7_22412390_ChIP-Seq_EML_Mouse1.61650393
34GATA2_21666600_ChIP-Seq_HMVEC_Human1.60511209
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.59104563
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57672712
37SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.56710984
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56190634
39KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.52075299
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.51264353
41TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.51182678
42GATA1_19941827_ChIP-Seq_MEL_Mouse1.47890555
43ZNF263_19887448_ChIP-Seq_K562_Human1.46974118
44* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.46551384
45* GATA2_19941826_ChIP-Seq_K562_Human1.45197946
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.41406309
47NFIB_24661679_ChIP-Seq_LUNG_Mouse1.41047484
48ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39313896
49NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.37376098
50SPI1_23127762_ChIP-Seq_K562_Human1.35238952
51KDM2B_26808549_Chip-Seq_JURKAT_Human1.35030802
52PPARA_22158963_ChIP-Seq_LIVER_Mouse1.34384696
53DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.30709915
54WT1_19549856_ChIP-ChIP_CCG9911_Human1.30398745
55ESR1_20079471_ChIP-ChIP_T-47D_Human1.29809775
56NCOR1_26117541_ChIP-Seq_K562_Human1.29665652
57LXR_22158963_ChIP-Seq_LIVER_Mouse1.28805099
58ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.28226066
59SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27702566
60ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27346540
61UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26248304
62SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24739179
63* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24452366
64TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.24416049
65HIF1A_21447827_ChIP-Seq_MCF-7_Human1.24324305
66VDR_21846776_ChIP-Seq_THP-1_Human1.23643163
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21938070
68EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.21921674
69FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.21370833
70ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20969567
71Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20486730
72CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15417721
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14133140
74SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14029429
75DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11591646
76* FOXA2_19822575_ChIP-Seq_HepG2_Human1.11159951
77NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.09845682
78TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09469319
79TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09191975
80SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07836664
81SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07836664
82BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06398757
83CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04966594
84SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04961027
85TET1_21490601_ChIP-Seq_MESCs_Mouse1.04774639
86MYC_22102868_ChIP-Seq_BL_Human1.03648255
87CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03494466
88PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03239843
89FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.03222688
90ATF3_27146783_Chip-Seq_COLON_Human1.02735827
91SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02195714
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02033846
93GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01113195
94TP53_23651856_ChIP-Seq_MEFs_Mouse1.00980456
95UBF1/2_26484160_Chip-Seq_HMECs_Human1.00480960
96CREB1_26743006_Chip-Seq_LNCaP_Human1.00190178
97ESR1_21235772_ChIP-Seq_MCF-7_Human0.99618244
98RUNX1_22412390_ChIP-Seq_EML_Mouse0.99268951
99EP300_21415370_ChIP-Seq_HL-1_Mouse0.99125747
100RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98524890

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.59717068
2MP0003705_abnormal_hypodermis_morpholog4.41321122
3MP0001958_emphysema2.91270936
4MP0005058_abnormal_lysosome_morphology2.81947415
5MP0005451_abnormal_body_composition2.81000256
6MP0005275_abnormal_skin_tensile2.78601240
7MP0003300_gastrointestinal_ulcer2.77410310
8MP0002877_abnormal_melanocyte_morpholog2.76263760
9MP0003191_abnormal_cellular_cholesterol2.64224034
10MP0003566_abnormal_cell_adhesion2.64008626
11MP0009840_abnormal_foam_cell2.51233130
12MP0005503_abnormal_tendon_morphology2.44132573
13MP0003279_aneurysm2.41365901
14MP0004272_abnormal_basement_membrane2.39622587
15MP0009780_abnormal_chondrocyte_physiolo2.32130558
16MP0003329_amyloid_beta_deposits2.13885438
17MP0000751_myopathy2.13184146
18MP0003091_abnormal_cell_migration2.01215305
19MP0003656_abnormal_erythrocyte_physiolo1.90675547
20MP0003172_abnormal_lysosome_physiology1.76231819
21MP0005409_darkened_coat_color1.74955404
22MP0005257_abnormal_intraocular_pressure1.64838150
23MP0008260_abnormal_autophagy1.45352696
24MP0000604_amyloidosis1.43797096
25MP0002060_abnormal_skin_morphology1.43262381
26MP0002896_abnormal_bone_mineralization1.41982807
27MP0010352_gastrointestinal_tract_polyps1.41652547
28MP0004233_abnormal_muscle_weight1.41135874
29MP0000747_muscle_weakness1.39559068
30MP0004858_abnormal_nervous_system1.38132148
31MP0005023_abnormal_wound_healing1.35058223
32MP0004084_abnormal_cardiac_muscle1.33746568
33MP0003045_fibrosis1.31268137
34MP0000003_abnormal_adipose_tissue1.26300830
35MP0004036_abnormal_muscle_relaxation1.20509130
36MP0003950_abnormal_plasma_membrane1.19715991
37MP0000767_abnormal_smooth_muscle1.15874715
38MP0000013_abnormal_adipose_tissue1.15357639
39MP0002295_abnormal_pulmonary_circulatio1.14444263
40MP0010234_abnormal_vibrissa_follicle1.13751973
41MP0010368_abnormal_lymphatic_system1.13232864
42MP0003690_abnormal_glial_cell1.12662702
43MP0005076_abnormal_cell_differentiation1.11108007
44MP0004130_abnormal_muscle_cell1.10985312
45MP0005165_increased_susceptibility_to1.08747295
46MP0004510_myositis1.08598959
47MP0000759_abnormal_skeletal_muscle1.07590489
48MP0000920_abnormal_myelination1.06773257
49MP0003436_decreased_susceptibility_to1.06237317
50MP0006138_congestive_heart_failure1.05401033
51MP0004087_abnormal_muscle_fiber1.04633355
52MP0006054_spinal_hemorrhage1.03093335
53MP0000678_abnormal_parathyroid_gland1.02322431
54MP0002971_abnormal_brown_adipose1.00795889
55MP0005164_abnormal_response_to1.00645333
56MP0001348_abnormal_lacrimal_gland1.00481888
57MP0001542_abnormal_bone_strength1.00113981
58MP0002269_muscular_atrophy0.99955044
59MP0005375_adipose_tissue_phenotype0.99654484
60MP0003828_pulmonary_edema0.99354168
61MP0002108_abnormal_muscle_morphology0.97539455
62MP0003634_abnormal_glial_cell0.96586984
63MP0002998_abnormal_bone_remodeling0.95667714
64MP0003075_altered_response_to0.95167431
65MP0000749_muscle_degeneration0.94224417
66MP0005330_cardiomyopathy0.94114782
67MP0001915_intracranial_hemorrhage0.93052069
68MP0000733_abnormal_muscle_development0.91472235
69MP0004947_skin_inflammation0.90717657
70MP0000681_abnormal_thyroid_gland0.90515952
71MP0005623_abnormal_meninges_morphology0.89221970
72MP0003453_abnormal_keratinocyte_physiol0.87989086
73MP0001849_ear_inflammation0.87508546
74MP0001243_abnormal_dermal_layer0.86233517
75MP0004883_abnormal_blood_vessel0.85322658
76MP0001533_abnormal_skeleton_physiology0.85064095
77MP0010630_abnormal_cardiac_muscle0.84789170
78MP0001299_abnormal_eye_distance/0.83614344
79MP0000858_altered_metastatic_potential0.83458006
80MP0003303_peritoneal_inflammation0.83105926
81MP0005083_abnormal_biliary_tract0.82542895
82MP0000343_altered_response_to0.80818323
83MP0005666_abnormal_adipose_tissue0.80757839
84MP0004859_abnormal_synaptic_plasticity0.76659427
85MP0005508_abnormal_skeleton_morphology0.76373709
86MP0003879_abnormal_hair_cell0.75766552
87MP0002168_other_aberrant_phenotype0.74801249
88MP0009384_cardiac_valve_regurgitation0.74660543
89MP0003959_abnormal_lean_body0.73734039
90MP0008004_abnormal_stomach_pH0.73559365
91MP0003795_abnormal_bone_structure0.72403816
92MP0003868_abnormal_feces_composition0.71718529
93MP0005621_abnormal_cell_physiology0.70837079
94MP0001661_extended_life_span0.68752556
95MP0002972_abnormal_cardiac_muscle0.68384871
96MP0004185_abnormal_adipocyte_glucose0.65929898
97MP0003221_abnormal_cardiomyocyte_apopto0.65250617
98MP0003183_abnormal_peptide_metabolism0.64468746
99MP0005390_skeleton_phenotype0.64204492
100MP0005595_abnormal_vascular_smooth0.64112982

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.82352859
2Premature rupture of membranes (HP:0001788)4.38189815
3Vascular tortuosity (HP:0004948)3.61176988
4Arterial tortuosity (HP:0005116)3.44927486
5Aortic aneurysm (HP:0004942)3.19501954
6Aortic dissection (HP:0002647)3.11819111
7Vertebral compression fractures (HP:0002953)3.09478759
8Cerebral aneurysm (HP:0004944)2.99248575
9Polycythemia (HP:0001901)2.92315938
10Dilatation of the ascending aorta (HP:0005111)2.77526552
11Increased connective tissue (HP:0009025)2.72723484
12Increased variability in muscle fiber diameter (HP:0003557)2.70528955
13Mitral stenosis (HP:0001718)2.62871060
14Bladder diverticulum (HP:0000015)2.62225294
15Wormian bones (HP:0002645)2.58035500
16Aneurysm (HP:0002617)2.57801256
17Fragile skin (HP:0001030)2.46833210
18Asymmetric septal hypertrophy (HP:0001670)2.44679980
19Atrophic scars (HP:0001075)2.43441726
20Spinal rigidity (HP:0003306)2.39792969
21Cervical subluxation (HP:0003308)2.34185503
22Abnormality of skeletal muscle fiber size (HP:0012084)2.33537100
23Type 1 muscle fiber predominance (HP:0003803)2.31487674
24Mitral regurgitation (HP:0001653)2.30712882
25Osteolytic defects of the hand bones (HP:0009699)2.29855796
26Osteolytic defects of the phalanges of the hand (HP:0009771)2.29855796
27Dysostosis multiplex (HP:0000943)2.29495066
28Soft skin (HP:0000977)2.26685387
29Neurofibrillary tangles (HP:0002185)2.25812022
30Upper limb amyotrophy (HP:0009129)2.23239966
31Distal upper limb amyotrophy (HP:0007149)2.23239966
32Urinary glycosaminoglycan excretion (HP:0003541)2.22926825
33Mucopolysacchariduria (HP:0008155)2.22926825
34Blue sclerae (HP:0000592)2.17596573
35Cholecystitis (HP:0001082)2.17007917
36Abnormal gallbladder physiology (HP:0012438)2.17007917
37Reticulocytosis (HP:0001923)2.16743155
38Peritonitis (HP:0002586)2.16112357
39Mildly elevated creatine phosphokinase (HP:0008180)2.14867059
40Short nail (HP:0001799)2.14646768
41Insomnia (HP:0100785)2.12929515
42Cerebral inclusion bodies (HP:0100314)2.11190611
43Hyperextensible skin (HP:0000974)2.11008577
44Abnormality of polysaccharide metabolism (HP:0011012)2.10543345
45Abnormality of glycosaminoglycan metabolism (HP:0004371)2.10543345
46Abnormality of mucopolysaccharide metabolism (HP:0011020)2.10543345
47Deep venous thrombosis (HP:0002625)2.07493128
48Hyporeflexia of lower limbs (HP:0002600)2.07353445
49Ankle contracture (HP:0006466)2.06212675
50Hyperacusis (HP:0010780)2.00249782
51Hand muscle atrophy (HP:0009130)1.99110613
52Mitral valve prolapse (HP:0001634)1.98443032
53Centrally nucleated skeletal muscle fibers (HP:0003687)1.97062006
54Shallow orbits (HP:0000586)1.96445549
55Distal lower limb muscle weakness (HP:0009053)1.95452367
56Joint laxity (HP:0001388)1.94867305
57Abnormality of complement system (HP:0005339)1.94342995
58Ankyloglossia (HP:0010296)1.94116074
59Spondylolisthesis (HP:0003302)1.93143790
60Interstitial pulmonary disease (HP:0006530)1.89584675
61Obstructive sleep apnea (HP:0002870)1.88722493
62Disproportionate tall stature (HP:0001519)1.87131128
63Distal lower limb amyotrophy (HP:0008944)1.86627274
64Atelectasis (HP:0100750)1.83590214
65Venous abnormality (HP:0002624)1.81690146
66Abnormality of the acetabulum (HP:0003170)1.81292178
67Broad metatarsal (HP:0001783)1.80625496
68Supranuclear gaze palsy (HP:0000605)1.78092782
69Exercise-induced myalgia (HP:0003738)1.77302207
70Asymmetry of the thorax (HP:0001555)1.77109064
71Complement deficiency (HP:0004431)1.73871386
72Broad face (HP:0000283)1.73806431
73Ovoid vertebral bodies (HP:0003300)1.72658342
74Follicular hyperkeratosis (HP:0007502)1.72292292
75Ulnar bowing (HP:0003031)1.72032680
76Skin nodule (HP:0200036)1.71370665
77Striae distensae (HP:0001065)1.71355135
78Abnormality of oral frenula (HP:0000190)1.71261204
79Abnormality of glycolipid metabolism (HP:0010969)1.70546632
80Abnormality of liposaccharide metabolism (HP:0010968)1.70546632
81Abnormality of glycosphingolipid metabolism (HP:0004343)1.70546632
82Slender build (HP:0001533)1.68556202
83Abnormality of the tricuspid valve (HP:0001702)1.67659538
84Neonatal short-limb short stature (HP:0008921)1.67454576
85Overgrowth (HP:0001548)1.65925596
86Abnormality of carpal bone ossification (HP:0006257)1.65377852
87Hypoplasia of the iris (HP:0007676)1.63960399
88Biconcave vertebral bodies (HP:0004586)1.63920577
89Genu recurvatum (HP:0002816)1.63163856
90Achilles tendon contracture (HP:0001771)1.62997923
91Hammertoe (HP:0001765)1.62621437
92Thin bony cortex (HP:0002753)1.62366033
93Thin skin (HP:0000963)1.62341518
94Decreased motor nerve conduction velocity (HP:0003431)1.62156215
95Vertebral arch anomaly (HP:0008438)1.60665385
96Coxa vara (HP:0002812)1.59605124
97Abnormal delivery (HP:0001787)1.57919754
98Foot dorsiflexor weakness (HP:0009027)1.57887287
99Cholelithiasis (HP:0001081)1.57480755
100Hyperparathyroidism (HP:0000843)1.56581952

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.77121424
2ERN13.08901492
3PRPF4B3.01669224
4ICK2.46467120
5RIPK12.45839043
6KSR22.41174561
7PDGFRA2.36671414
8TTN1.96250874
9EPHB11.94388114
10MAP3K21.91943743
11LMTK21.79069936
12FGFR41.75038413
13SIK11.73677819
14EEF2K1.68747580
15PKN21.66189842
16SCYL21.63749458
17MAP3K61.54995017
18MAP2K31.48308344
19TESK11.48109649
20NEK91.46742795
21NTRK11.40842681
22RET1.37480664
23RIPK41.33889697
24MYLK1.31754436
25DDR21.31565186
26CDK121.30314242
27STK381.30164121
28NTRK31.28718747
29JAK11.26829805
30FGFR31.26430971
31IRAK31.23691248
32CDC42BPA1.21612358
33TYK21.17743871
34PTK21.14810821
35TGFBR21.12890960
36MAP3K11.10885728
37MAP3K31.10576169
38EPHA31.08084876
39DMPK1.04363831
40AKT31.03711508
41ZAP701.02527700
42MARK20.99223528
43MAP3K130.99007258
44KSR10.98582834
45PAK60.97061933
46TRPM70.95037269
47WNK10.94315113
48PDGFRB0.91776887
49SMG10.91428490
50CLK10.91039786
51RAF10.89574446
52MTOR0.88884488
53PDPK10.87029038
54LATS20.85780509
55PAK20.85486513
56MET0.84713678
57SGK30.84554830
58MAP3K70.83896442
59PRKD20.83847566
60PRKD30.83597790
61MAPK120.81487461
62JAK20.80532321
63PTK60.76983459
64HIPK20.75362438
65CAMKK10.69948965
66TAOK20.66564193
67ROCK20.64810584
68BMX0.64343511
69MAP2K10.63168214
70LIMK10.61847686
71RPS6KA20.61143272
72PAK40.59829461
73MST1R0.58850092
74MOS0.58525380
75PDK10.58282373
76EIF2AK10.57912061
77PRKG20.56785728
78LRRK20.56444944
79JAK30.56246373
80EPHA20.55226167
81MAPK110.53940409
82ROCK10.51355161
83PRKD10.49447838
84MARK10.49018057
85FER0.47279321
86ARAF0.47248982
87TBK10.46556859
88PIK3CG0.46377454
89SGK2230.44081842
90SGK4940.44081842
91MAP3K80.43965554
92CAMKK20.43414326
93SGK20.42204899
94MAPK70.41172027
95MAPKAPK30.41009299
96MUSK0.37998007
97TESK20.36362418
98MAPK100.35111698
99BLK0.34483317
100PRKAA20.33705923

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.52793406
2Other glycan degradation_Homo sapiens_hsa005112.27163905
3Glycosaminoglycan degradation_Homo sapiens_hsa005311.82824972
4Chronic myeloid leukemia_Homo sapiens_hsa052201.73335364
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.72955053
6AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.56005906
7Focal adhesion_Homo sapiens_hsa045101.55616579
8Renal cell carcinoma_Homo sapiens_hsa052111.51955133
9Non-small cell lung cancer_Homo sapiens_hsa052231.47873601
10Pancreatic cancer_Homo sapiens_hsa052121.46634097
11Acute myeloid leukemia_Homo sapiens_hsa052211.45651471
12Prion diseases_Homo sapiens_hsa050201.43961985
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.42023352
14VEGF signaling pathway_Homo sapiens_hsa043701.35867420
15Endometrial cancer_Homo sapiens_hsa052131.32194907
16mTOR signaling pathway_Homo sapiens_hsa041501.30562027
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.29727580
18Glioma_Homo sapiens_hsa052141.29374915
19ECM-receptor interaction_Homo sapiens_hsa045121.20872631
20Neurotrophin signaling pathway_Homo sapiens_hsa047221.19589205
21Insulin signaling pathway_Homo sapiens_hsa049101.18397380
22Central carbon metabolism in cancer_Homo sapiens_hsa052301.17628873
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16766122
24Complement and coagulation cascades_Homo sapiens_hsa046101.15457243
25Amoebiasis_Homo sapiens_hsa051461.13958866
26Thyroid hormone signaling pathway_Homo sapiens_hsa049191.11789418
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08609135
28Prolactin signaling pathway_Homo sapiens_hsa049171.07873109
29ErbB signaling pathway_Homo sapiens_hsa040121.07843945
30GnRH signaling pathway_Homo sapiens_hsa049121.05585304
31Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04376452
32Proteoglycans in cancer_Homo sapiens_hsa052051.04088916
33Thyroid cancer_Homo sapiens_hsa052161.03784692
34Dilated cardiomyopathy_Homo sapiens_hsa054141.03596344
35Lysosome_Homo sapiens_hsa041421.03353664
36Phospholipase D signaling pathway_Homo sapiens_hsa040720.99930024
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.99380976
38Adherens junction_Homo sapiens_hsa045200.97107602
39Long-term potentiation_Homo sapiens_hsa047200.96608253
40Vibrio cholerae infection_Homo sapiens_hsa051100.96046625
41Adipocytokine signaling pathway_Homo sapiens_hsa049200.94484901
42Estrogen signaling pathway_Homo sapiens_hsa049150.93342803
43Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93020009
44Leukocyte transendothelial migration_Homo sapiens_hsa046700.92372507
45AMPK signaling pathway_Homo sapiens_hsa041520.92101462
46Endocytosis_Homo sapiens_hsa041440.91706464
47Choline metabolism in cancer_Homo sapiens_hsa052310.88746224
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88474621
49Insulin resistance_Homo sapiens_hsa049310.87456419
50Osteoclast differentiation_Homo sapiens_hsa043800.87228387
51Bladder cancer_Homo sapiens_hsa052190.87063179
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87017740
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86364015
54Inositol phosphate metabolism_Homo sapiens_hsa005620.86045938
55Type II diabetes mellitus_Homo sapiens_hsa049300.85905773
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84625325
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82470036
58Hepatitis C_Homo sapiens_hsa051600.79022767
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78705430
60Sphingolipid signaling pathway_Homo sapiens_hsa040710.78466076
61Bile secretion_Homo sapiens_hsa049760.76905774
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74737211
63Small cell lung cancer_Homo sapiens_hsa052220.74259923
64Prostate cancer_Homo sapiens_hsa052150.73919454
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73641199
66B cell receptor signaling pathway_Homo sapiens_hsa046620.73572456
67HIF-1 signaling pathway_Homo sapiens_hsa040660.71459762
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71040403
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70775184
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70667217
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69075410
72Synaptic vesicle cycle_Homo sapiens_hsa047210.68641146
73Protein digestion and absorption_Homo sapiens_hsa049740.66334174
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65406077
75Toxoplasmosis_Homo sapiens_hsa051450.65291545
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64974267
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64685728
78Gap junction_Homo sapiens_hsa045400.64477928
79Thyroid hormone synthesis_Homo sapiens_hsa049180.64293641
80FoxO signaling pathway_Homo sapiens_hsa040680.64105177
81Pentose phosphate pathway_Homo sapiens_hsa000300.63525477
82Malaria_Homo sapiens_hsa051440.63371028
83PPAR signaling pathway_Homo sapiens_hsa033200.62015575
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61054239
85Platelet activation_Homo sapiens_hsa046110.60732387
86Hepatitis B_Homo sapiens_hsa051610.58833792
87Fructose and mannose metabolism_Homo sapiens_hsa000510.58377315
88Arginine biosynthesis_Homo sapiens_hsa002200.58327115
89Phenylalanine metabolism_Homo sapiens_hsa003600.57993196
90Colorectal cancer_Homo sapiens_hsa052100.56842466
91Notch signaling pathway_Homo sapiens_hsa043300.56668587
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56653763
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56121358
94Phagosome_Homo sapiens_hsa041450.56004901
95Pertussis_Homo sapiens_hsa051330.53968317
96TNF signaling pathway_Homo sapiens_hsa046680.52792051
97Circadian rhythm_Homo sapiens_hsa047100.52033358
98Galactose metabolism_Homo sapiens_hsa000520.51265472
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50622052
100Shigellosis_Homo sapiens_hsa051310.50538651

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