C6ORF47

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.48461461
2positive regulation by symbiont of host defense response (GO:0052509)4.40277515
3modulation by symbiont of host defense response (GO:0052031)4.40277515
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.40277515
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.40277515
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.40277515
7modulation by symbiont of host immune response (GO:0052553)4.40277515
8response to peptidoglycan (GO:0032494)4.29306762
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.26622563
10antigen processing and presentation of endogenous antigen (GO:0019883)4.21075389
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.11828019
12negative regulation of cell killing (GO:0031342)4.11828019
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.98938835
14detection of other organism (GO:0098543)3.94784027
15positive regulation of gamma-delta T cell activation (GO:0046645)3.94432709
16detection of bacterium (GO:0016045)3.80759102
17macrophage activation involved in immune response (GO:0002281)3.69856357
18negative regulation of erythrocyte differentiation (GO:0045647)3.66733878
19neutrophil activation involved in immune response (GO:0002283)3.59342497
20negative regulation of interleukin-12 production (GO:0032695)3.56097093
21immunoglobulin mediated immune response (GO:0016064)3.55146771
22detection of external biotic stimulus (GO:0098581)3.45949866
23protein localization to endosome (GO:0036010)3.36845731
24detection of molecule of bacterial origin (GO:0032490)3.35784665
25regulation of interferon-beta biosynthetic process (GO:0045357)3.33102074
26cellular response to type I interferon (GO:0071357)3.32277986
27type I interferon signaling pathway (GO:0060337)3.32277986
28response to type I interferon (GO:0034340)3.32207033
29NIK/NF-kappaB signaling (GO:0038061)3.26084567
30barbed-end actin filament capping (GO:0051016)3.16511987
31lipopolysaccharide-mediated signaling pathway (GO:0031663)3.16208701
32positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.15064546
33positive regulation of Cdc42 GTPase activity (GO:0043089)3.12684705
34positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.08393377
35regulation of mast cell degranulation (GO:0043304)3.04517733
36response to muramyl dipeptide (GO:0032495)3.04215840
37regulation of leukocyte degranulation (GO:0043300)3.03015046
38negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.99615298
39mannose metabolic process (GO:0006013)2.97767135
40regulation of myeloid leukocyte mediated immunity (GO:0002886)2.95726939
41detection of biotic stimulus (GO:0009595)2.94700780
42response to host immune response (GO:0052572)2.94024435
43response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.94024435
44germinal center formation (GO:0002467)2.93083285
45glycosphingolipid catabolic process (GO:0046479)2.92952810
46regulation of type I interferon-mediated signaling pathway (GO:0060338)2.92181706
47interferon-gamma-mediated signaling pathway (GO:0060333)2.87875513
48modulation by symbiont of host cellular process (GO:0044068)2.83027842
49response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.82421515
50response to host (GO:0075136)2.82421515
51response to host defenses (GO:0052200)2.82421515
52myeloid dendritic cell differentiation (GO:0043011)2.81033257
53regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.79413203
54cellular extravasation (GO:0045123)2.78938961
55positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.77968572
56regulation of gamma-delta T cell activation (GO:0046643)2.75515935
57leukocyte aggregation (GO:0070486)2.73406238
58negative regulation of toll-like receptor signaling pathway (GO:0034122)2.72906342
59respiratory burst (GO:0045730)2.69416133
60glycolipid catabolic process (GO:0019377)2.66446899
61T-helper 1 type immune response (GO:0042088)2.66087409
62regulation of necroptotic process (GO:0060544)2.65512967
63positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.63596334
64regulation of mast cell activation involved in immune response (GO:0033006)2.63324264
65cellular response to virus (GO:0098586)2.63180953
66pinocytosis (GO:0006907)2.62813925
67negative regulation of innate immune response (GO:0045824)2.60517289
68regulation of dendritic cell antigen processing and presentation (GO:0002604)2.60247107
69response to laminar fluid shear stress (GO:0034616)2.59962058
70myeloid cell activation involved in immune response (GO:0002275)2.59453856
71positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.58706262
72amino sugar catabolic process (GO:0046348)2.56886339
73regulation of T-helper 2 cell differentiation (GO:0045628)2.54169730
74regulation of antigen processing and presentation (GO:0002577)2.53324284
75regulation of necrotic cell death (GO:0010939)2.49049966
76B cell mediated immunity (GO:0019724)2.48960227
77epithelial cell differentiation involved in prostate gland development (GO:0060742)2.48397903
78positive regulation of cellular amide metabolic process (GO:0034250)2.48186060
79macrophage activation (GO:0042116)2.48153443
80negative regulation of cytokine production involved in immune response (GO:0002719)2.46885975
81positive regulation of interferon-alpha production (GO:0032727)2.46698706
82modulation by virus of host process (GO:0019054)2.44500027
83myeloid dendritic cell activation (GO:0001773)2.43899231
84positive regulation of tumor necrosis factor production (GO:0032760)2.43512704
85regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.42636761
86regulation of B cell receptor signaling pathway (GO:0050855)2.42406168
87granulocyte activation (GO:0036230)2.41955266
88negative regulation of leukocyte mediated immunity (GO:0002704)2.41748758
89response to protozoan (GO:0001562)2.41474090
90regulation of interferon-alpha production (GO:0032647)2.41351035
91defense response to protozoan (GO:0042832)2.40072360
92regulation of regulated secretory pathway (GO:1903305)2.39247991
93regulation of superoxide anion generation (GO:0032928)2.39135583
94regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.38533121
95COPI coating of Golgi vesicle (GO:0048205)2.37282655
96Golgi transport vesicle coating (GO:0048200)2.37282655
97positive regulation of type 2 immune response (GO:0002830)2.35930105
983-UTR-mediated mRNA stabilization (GO:0070935)2.34286924
99negative regulation of necroptotic process (GO:0060546)2.33893841
100interferon-gamma secretion (GO:0072643)2.33607126

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.23215259
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.06698538
3NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.76508660
4BP1_19119308_ChIP-ChIP_Hs578T_Human2.55072867
5MYC_22102868_ChIP-Seq_BL_Human2.43915975
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.39971348
7LXR_22292898_ChIP-Seq_THP-1_Human2.38799832
8ELK3_25401928_ChIP-Seq_HUVEC_Human2.36526136
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.19905653
10VDR_24763502_ChIP-Seq_THP-1_Human2.18510622
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.16440796
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.12740378
13TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08221104
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.05057104
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04103185
16KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.02462252
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.01976000
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01806588
19MAF_26560356_Chip-Seq_TH1_Human1.94015373
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.91152172
21KDM2B_26808549_Chip-Seq_DND41_Human1.87583444
22RACK7_27058665_Chip-Seq_MCF-7_Human1.87485881
23EGR1_19374776_ChIP-ChIP_THP-1_Human1.84809893
24TCF7_22412390_ChIP-Seq_EML_Mouse1.84575325
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.75643302
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74814246
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.73389295
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.72939597
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.71411119
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.70169322
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69938329
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.69425502
33MAF_26560356_Chip-Seq_TH2_Human1.68592618
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.68467363
35UTX_26944678_Chip-Seq_JUKART_Human1.68362977
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.67926490
37SPI1_23127762_ChIP-Seq_K562_Human1.63363660
38SPI1_23547873_ChIP-Seq_NB4_Human1.62796087
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.49558104
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.46219790
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.44718160
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.44539851
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43577938
44TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41170594
45EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.39370949
46DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.39066926
47CTCF_27219007_Chip-Seq_ERYTHROID_Human1.38903852
48IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.37070297
49PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36976021
50GATA1_22383799_ChIP-Seq_G1ME_Mouse1.36131874
51CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35186801
52NCOR1_26117541_ChIP-Seq_K562_Human1.35165759
53KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33608536
54TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32624628
55IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32357880
56BCOR_27268052_Chip-Seq_Bcells_Human1.31165803
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30022096
58P68_20966046_ChIP-Seq_HELA_Human1.29168936
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28402231
60SA1_27219007_Chip-Seq_ERYTHROID_Human1.27290231
61CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25224728
62KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24366323
63GATA1_19941827_ChIP-Seq_MEL_Mouse1.23957616
64ESR2_21235772_ChIP-Seq_MCF-7_Human1.23877619
65BCL6_27268052_Chip-Seq_Bcells_Human1.23798311
66TET1_21451524_ChIP-Seq_MESCs_Mouse1.22489254
67STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.21802371
68ZNF263_19887448_ChIP-Seq_K562_Human1.21346400
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21152473
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.19283782
71ELF1_20517297_ChIP-Seq_JURKAT_Human1.19030584
72SCL_19346495_ChIP-Seq_HPC-7_Human1.18466026
73TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16412660
74KDM2B_26808549_Chip-Seq_K562_Human1.15714335
75UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15270216
76SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14025785
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13487039
78PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13287133
79RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12895535
80MYB_26560356_Chip-Seq_TH1_Human1.12874702
81PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11900183
82TFEB_21752829_ChIP-Seq_HELA_Human1.10937494
83GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10661924
84ATF3_27146783_Chip-Seq_COLON_Human1.10659974
85CLOCK_20551151_ChIP-Seq_293T_Human1.09585764
86SMC4_20622854_ChIP-Seq_HELA_Human1.08141670
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05807961
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05356813
89Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05285294
90PPARA_22158963_ChIP-Seq_LIVER_Mouse1.03810988
91SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02661235
92P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02043806
93ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01364132
94LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00603896
95* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00401375
96MYB_26560356_Chip-Seq_TH2_Human1.00320278
97GATA1_19941826_ChIP-Seq_K562_Human0.99716151
98RXR_22158963_ChIP-Seq_LIVER_Mouse0.99184954
99STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.98736180
100CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98484448

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.84315100
2MP0005058_abnormal_lysosome_morphology3.54931066
3MP0005451_abnormal_body_composition3.43620562
4MP0003436_decreased_susceptibility_to3.27810550
5MP0009840_abnormal_foam_cell3.13661432
6MP0003724_increased_susceptibility_to2.91160008
7MP0003191_abnormal_cellular_cholesterol2.72766312
8MP0001835_abnormal_antigen_presentation2.68978278
9MP0003300_gastrointestinal_ulcer2.38572707
10MP0002419_abnormal_innate_immunity2.36373520
11MP0005025_abnormal_response_to2.27193526
12MP0009785_altered_susceptibility_to2.25221292
13MP0005387_immune_system_phenotype2.23566329
14MP0001790_abnormal_immune_system2.23566329
15MP0003705_abnormal_hypodermis_morpholog2.17066692
16MP0000685_abnormal_immune_system2.16237347
17MP0008260_abnormal_autophagy2.12034206
18MP0005000_abnormal_immune_tolerance2.11628787
19MP0002148_abnormal_hypersensitivity_rea2.02036588
20MP0003172_abnormal_lysosome_physiology2.00845890
21MP0006082_CNS_inflammation2.00464577
22MP0004510_myositis2.00430155
23MP0004947_skin_inflammation1.96315511
24MP0001800_abnormal_humoral_immune1.93804696
25MP0002452_abnormal_antigen_presenting1.93335880
26MP0002723_abnormal_immune_serum1.86684823
27MP0005464_abnormal_platelet_physiology1.80491577
28MP0009278_abnormal_bone_marrow1.79138857
29MP0001819_abnormal_immune_cell1.78545828
30MP0002420_abnormal_adaptive_immunity1.78407800
31MP0001533_abnormal_skeleton_physiology1.75258234
32MP0005671_abnormal_response_to1.74417522
33MP0003453_abnormal_keratinocyte_physiol1.73328627
34MP0003763_abnormal_thymus_physiology1.70973549
35MP0000858_altered_metastatic_potential1.67552642
36MP0010155_abnormal_intestine_physiology1.65750497
37MP0000343_altered_response_to1.58662006
38MP0001849_ear_inflammation1.57024884
39MP0003806_abnormal_nucleotide_metabolis1.54638917
40MP0009333_abnormal_splenocyte_physiolog1.52201034
41MP0010234_abnormal_vibrissa_follicle1.51666926
42MP0001845_abnormal_inflammatory_respons1.49794635
43MP0002998_abnormal_bone_remodeling1.45952168
44MP0003075_altered_response_to1.41787782
45MP0002405_respiratory_system_inflammati1.39965103
46MP0003828_pulmonary_edema1.36787398
47MP0000716_abnormal_immune_system1.34899789
48MP0003566_abnormal_cell_adhesion1.33056522
49MP0008469_abnormal_protein_level1.31855283
50MP0002398_abnormal_bone_marrow1.29279336
51MP0003183_abnormal_peptide_metabolism1.26820317
52MP0002877_abnormal_melanocyte_morpholog1.26010001
53MP0002132_abnormal_respiratory_system1.23224159
54MP0000604_amyloidosis1.22405301
55MP0003091_abnormal_cell_migration1.22069084
56MP0001545_abnormal_hematopoietic_system1.19156548
57MP0005397_hematopoietic_system_phenotyp1.19156548
58MP0009764_decreased_sensitivity_to1.16854011
59MP0002722_abnormal_immune_system1.14930475
60MP0002429_abnormal_blood_cell1.14253711
61MP0005166_decreased_susceptibility_to1.13985287
62MP0008004_abnormal_stomach_pH1.11652778
63MP0000490_abnormal_crypts_of1.11295079
64MP0000689_abnormal_spleen_morphology1.08726220
65MP0001853_heart_inflammation1.05227641
66MP0000465_gastrointestinal_hemorrhage1.03763729
67MP0002796_impaired_skin_barrier1.03331976
68MP0002139_abnormal_hepatobiliary_system1.00044713
69MP0003656_abnormal_erythrocyte_physiolo0.99970831
70MP0002254_reproductive_system_inflammat0.99521245
71MP0004381_abnormal_hair_follicle0.99035062
72MP0003866_abnormal_defecation0.94443697
73MP0005257_abnormal_intraocular_pressure0.90701382
74MP0003329_amyloid_beta_deposits0.89242596
75MP0000703_abnormal_thymus_morphology0.87450442
76MP0003448_altered_tumor_morphology0.87308263
77MP0005310_abnormal_salivary_gland0.86919245
78MP0000747_muscle_weakness0.86058337
79MP0005023_abnormal_wound_healing0.85855429
80MP0005164_abnormal_response_to0.85679978
81MP0005390_skeleton_phenotype0.85103162
82MP0002138_abnormal_hepatobiliary_system0.85037293
83MP0004883_abnormal_blood_vessel0.84659218
84MP0005076_abnormal_cell_differentiation0.83951810
85MP0001873_stomach_inflammation0.83252663
86MP0004858_abnormal_nervous_system0.81732617
87MP0003795_abnormal_bone_structure0.79420341
88MP0005501_abnormal_skin_physiology0.78208547
89MP0003221_abnormal_cardiomyocyte_apopto0.77899414
90MP0000750_abnormal_muscle_regeneration0.77287511
91MP0001851_eye_inflammation0.75921017
92MP0005409_darkened_coat_color0.74945756
93MP0004264_abnormal_extraembryonic_tissu0.74856716
94MP0001216_abnormal_epidermal_layer0.74814154
95MP0002396_abnormal_hematopoietic_system0.74664344
96MP0002332_abnormal_exercise_endurance0.72500646
97MP0001663_abnormal_digestive_system0.72333655
98MP0004185_abnormal_adipocyte_glucose0.71941100
99MP0004233_abnormal_muscle_weight0.71571330
100MP0009763_increased_sensitivity_to0.71211361

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.72857583
2Abnormality of macrophages (HP:0004311)4.25692758
3Abnormality of glycolipid metabolism (HP:0010969)4.13973225
4Abnormality of liposaccharide metabolism (HP:0010968)4.13973225
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.13973225
6Recurrent abscess formation (HP:0002722)3.80480431
7Recurrent bacterial skin infections (HP:0005406)3.79066796
8Orchitis (HP:0100796)3.20541572
9Myositis (HP:0100614)3.19278274
10Mediastinal lymphadenopathy (HP:0100721)3.16760966
11Dysostosis multiplex (HP:0000943)3.07794324
12Systemic lupus erythematosus (HP:0002725)2.95620597
13Colitis (HP:0002583)2.94928246
14Increased cerebral lipofuscin (HP:0011813)2.88223552
15Loss of speech (HP:0002371)2.86502814
16Obstructive lung disease (HP:0006536)2.84953406
17Chronic obstructive pulmonary disease (HP:0006510)2.84953406
18Recurrent gram-negative bacterial infections (HP:0005420)2.78042521
19Cellulitis (HP:0100658)2.77149968
20Increased IgE level (HP:0003212)2.72439436
21Vacuolated lymphocytes (HP:0001922)2.71619270
22Vertebral compression fractures (HP:0002953)2.61329606
23Retrobulbar optic neuritis (HP:0100654)2.61292309
24Optic neuritis (HP:0100653)2.61292309
25Elevated erythrocyte sedimentation rate (HP:0003565)2.57722787
26Centrally nucleated skeletal muscle fibers (HP:0003687)2.50807499
27Petechiae (HP:0000967)2.46818212
28Gastrointestinal inflammation (HP:0004386)2.45657541
29Axonal loss (HP:0003447)2.44210163
30Gingivitis (HP:0000230)2.44189426
31Inflammation of the large intestine (HP:0002037)2.43078347
32Gastrointestinal infarctions (HP:0005244)2.41051344
33Abnormality of glycosaminoglycan metabolism (HP:0004371)2.39608067
34Abnormality of mucopolysaccharide metabolism (HP:0011020)2.39608067
35Abnormality of polysaccharide metabolism (HP:0011012)2.39608067
36Urticaria (HP:0001025)2.39507252
37Meningitis (HP:0001287)2.36301032
38Interstitial pulmonary disease (HP:0006530)2.35795614
39Urinary glycosaminoglycan excretion (HP:0003541)2.34957498
40Mucopolysacchariduria (HP:0008155)2.34957498
41Recurrent fungal infections (HP:0002841)2.34433475
42Amyloidosis (HP:0011034)2.29228920
43Recurrent skin infections (HP:0001581)2.29019487
44Spontaneous hematomas (HP:0007420)2.27986741
45Increased neuronal autofluorescent lipopigment (HP:0002074)2.27272419
46Increased serum ferritin (HP:0003281)2.24978354
47Hypertensive crisis (HP:0100735)2.23872908
48Purpura (HP:0000979)2.23802038
49Thin bony cortex (HP:0002753)2.18101378
50Vasculitis (HP:0002633)2.16243362
51Hemorrhage of the eye (HP:0011885)2.10703957
52Distal lower limb muscle weakness (HP:0009053)2.09651137
53Recurrent viral infections (HP:0004429)2.08161813
54Thoracic kyphosis (HP:0002942)2.05897797
55Keratoconjunctivitis sicca (HP:0001097)2.05672336
56Distal lower limb amyotrophy (HP:0008944)2.03479925
57Hepatosplenomegaly (HP:0001433)2.01882824
58Myocardial infarction (HP:0001658)2.00227210
59Hypergammaglobulinemia (HP:0010702)1.96309521
60Increased IgM level (HP:0003496)1.96287701
61Pustule (HP:0200039)1.95973163
62Gastrointestinal stroma tumor (HP:0100723)1.93494577
63Neuronal loss in central nervous system (HP:0002529)1.93328503
64Segmental peripheral demyelination/remyelination (HP:0003481)1.92434753
65Upper motor neuron abnormality (HP:0002127)1.92278321
66Cerebral aneurysm (HP:0004944)1.91147871
67Abnormality of the nasal mucosa (HP:0000433)1.88085632
68Increased connective tissue (HP:0009025)1.87964057
69Malnutrition (HP:0004395)1.87237083
70Granulocytopenia (HP:0001913)1.86692078
71Osteomyelitis (HP:0002754)1.86477934
72Abnormality of the thoracic spine (HP:0100711)1.86114481
73Bone pain (HP:0002653)1.84916620
74Pulmonary infiltrates (HP:0002113)1.83983268
75Epistaxis (HP:0000421)1.82775854
76Hypertriglyceridemia (HP:0002155)1.82205535
77Chronic mucocutaneous candidiasis (HP:0002728)1.81875481
78Recurrent cutaneous fungal infections (HP:0011370)1.81875481
79Premature loss of primary teeth (HP:0006323)1.80777221
80Polycythemia (HP:0001901)1.79453779
81Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.79225868
82Achilles tendon contracture (HP:0001771)1.78899515
83Peritonitis (HP:0002586)1.78653548
84Emphysema (HP:0002097)1.77623519
85Ragged-red muscle fibers (HP:0003200)1.77091433
86Restrictive lung disease (HP:0002091)1.76253590
87Abnormality of the peritoneum (HP:0002585)1.75450077
88Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.74350166
89Asymmetric septal hypertrophy (HP:0001670)1.74038012
90Progressive neurologic deterioration (HP:0002344)1.73987936
91Increased variability in muscle fiber diameter (HP:0003557)1.73523634
92Stomatitis (HP:0010280)1.71966432
93Cardiomegaly (HP:0001640)1.71836758
94Polygenic inheritance (HP:0010982)1.71808168
95Abnormality of skeletal muscle fiber size (HP:0012084)1.71781478
96Exercise-induced myalgia (HP:0003738)1.71723922
97Keratoconjunctivitis (HP:0001096)1.70111926
98Chest pain (HP:0100749)1.69805594
99Hyperacusis (HP:0010780)1.69642846
100Arterial thrombosis (HP:0004420)1.69641865

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.76624016
2PRPF4B3.14821366
3TRIB32.93330167
4IRAK32.89289052
5NME22.78295161
6RIPK42.72625201
7MAP4K12.47321917
8BLK2.29200594
9MAP2K32.19721401
10SIK12.08568905
11TYK22.03589093
12MAP3K111.91876036
13SMG11.85561517
14IRAK41.83938748
15TESK21.82929566
16ICK1.79804815
17MAP3K31.75936989
18TBK11.74021579
19CSK1.71306159
20TAOK21.65359129
21EPHB11.65339274
22MAP3K11.58172863
23ARAF1.55997590
24TAOK11.50416652
25MAP3K131.47838373
26MAP3K141.46597907
27RIPK11.46186705
28ZAP701.44644684
29PIM21.27394861
30MARK31.27271003
31TESK11.24459316
32SIK31.20243794
33KSR21.16592629
34CDC42BPA1.15418237
35IRAK21.14813607
36FGFR41.14090901
37EPHA21.13736531
38BTK1.10539656
39JAK31.10083306
40TTN1.08752535
41GRK61.08742083
42TGFBR21.05452944
43FGR0.99038329
44PAK40.96188305
45JAK10.95112278
46IKBKE0.94780926
47MOS0.92424894
48EEF2K0.91789362
49PRKD20.88121527
50PKN20.87931464
51HCK0.87341348
52PTK60.87273711
53CSF1R0.87141397
54SIK20.87119171
55PDPK10.87097356
56FES0.85980440
57MARK20.85513038
58LRRK20.84581281
59MAP3K100.83398407
60JAK20.82392775
61MATK0.81855114
62IKBKB0.78227484
63MAP3K60.74874235
64MAPK110.71005261
65TNK20.70932750
66HIPK20.70662761
67STK100.68469048
68SYK0.65799151
69MAP3K80.64733517
70DYRK1B0.63147959
71LYN0.63129885
72DDR20.61610162
73RPS6KA20.61232687
74MAPK120.60702922
75CDK120.60201302
76BMX0.57138051
77RAF10.56922880
78PDK10.56645980
79BRAF0.56107163
80MAP3K50.54597610
81RET0.53481878
82RPS6KC10.52823882
83RPS6KL10.52823882
84ABL20.52002227
85GRK70.48125637
86LCK0.48124232
87BMPR20.47966620
88MAPKAPK20.47136493
89MTOR0.46997704
90MAP3K20.45577656
91MST1R0.45325924
92PRKG20.44182470
93MAPKAPK30.43992320
94PAK10.43901618
95CDK40.43420444
96PDGFRA0.42612671
97CHUK0.37132399
98CLK10.36711053
99KIT0.36193588
100IRAK10.34866223

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.11236030
2Leishmaniasis_Homo sapiens_hsa051402.45938743
3Osteoclast differentiation_Homo sapiens_hsa043802.42699393
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.34295999
5Staphylococcus aureus infection_Homo sapiens_hsa051502.33531446
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.07383354
7Allograft rejection_Homo sapiens_hsa053302.03235889
8B cell receptor signaling pathway_Homo sapiens_hsa046622.02565439
9Tuberculosis_Homo sapiens_hsa051521.98976114
10Acute myeloid leukemia_Homo sapiens_hsa052211.95475740
11Graft-versus-host disease_Homo sapiens_hsa053321.87432333
12Lysosome_Homo sapiens_hsa041421.81344981
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.79363526
14Autoimmune thyroid disease_Homo sapiens_hsa053201.77769473
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.72574885
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.69986428
17Viral myocarditis_Homo sapiens_hsa054161.67936836
18Toxoplasmosis_Homo sapiens_hsa051451.64091783
19Influenza A_Homo sapiens_hsa051641.52793187
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.52262531
21Phagosome_Homo sapiens_hsa041451.51988097
22Malaria_Homo sapiens_hsa051441.51163414
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.42037828
24Apoptosis_Homo sapiens_hsa042101.39788598
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39589868
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.39427531
27Asthma_Homo sapiens_hsa053101.38499800
28Antigen processing and presentation_Homo sapiens_hsa046121.37821879
29Hepatitis C_Homo sapiens_hsa051601.37274369
30Herpes simplex infection_Homo sapiens_hsa051681.36480246
31Chronic myeloid leukemia_Homo sapiens_hsa052201.34621282
32TNF signaling pathway_Homo sapiens_hsa046681.32156532
33Hepatitis B_Homo sapiens_hsa051611.30871485
34Salmonella infection_Homo sapiens_hsa051321.28985791
35Pertussis_Homo sapiens_hsa051331.28048734
36Type I diabetes mellitus_Homo sapiens_hsa049401.27431152
37Measles_Homo sapiens_hsa051621.25267566
38Non-small cell lung cancer_Homo sapiens_hsa052231.24017860
39Bladder cancer_Homo sapiens_hsa052191.23191539
40Shigellosis_Homo sapiens_hsa051311.22100157
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.20812872
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20767956
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.20605416
44Rheumatoid arthritis_Homo sapiens_hsa053231.18768854
45Notch signaling pathway_Homo sapiens_hsa043301.15444947
46Pancreatic cancer_Homo sapiens_hsa052121.15386561
47VEGF signaling pathway_Homo sapiens_hsa043701.13644636
48Legionellosis_Homo sapiens_hsa051341.13575485
49Fructose and mannose metabolism_Homo sapiens_hsa000511.08460126
50Galactose metabolism_Homo sapiens_hsa000521.04469565
51Leukocyte transendothelial migration_Homo sapiens_hsa046701.03596190
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03086736
53Hematopoietic cell lineage_Homo sapiens_hsa046401.01591255
54Chemokine signaling pathway_Homo sapiens_hsa040621.01496159
55Primary immunodeficiency_Homo sapiens_hsa053400.99303539
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95661636
57Endometrial cancer_Homo sapiens_hsa052130.95100055
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.94612158
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94505430
60T cell receptor signaling pathway_Homo sapiens_hsa046600.94442919
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.90360048
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90285302
63Pentose phosphate pathway_Homo sapiens_hsa000300.87411881
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.84387339
65Viral carcinogenesis_Homo sapiens_hsa052030.83967036
66Endocytosis_Homo sapiens_hsa041440.81765308
67Renal cell carcinoma_Homo sapiens_hsa052110.80517162
68Epstein-Barr virus infection_Homo sapiens_hsa051690.79412979
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78943984
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76787426
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.75074871
72Prolactin signaling pathway_Homo sapiens_hsa049170.75014789
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.71134292
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69501804
75Insulin signaling pathway_Homo sapiens_hsa049100.69485370
76Amoebiasis_Homo sapiens_hsa051460.68485485
77Prion diseases_Homo sapiens_hsa050200.67734203
78HTLV-I infection_Homo sapiens_hsa051660.67010161
79Insulin resistance_Homo sapiens_hsa049310.66317938
80Thyroid cancer_Homo sapiens_hsa052160.63649826
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62829896
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59159368
83mTOR signaling pathway_Homo sapiens_hsa041500.56622541
84African trypanosomiasis_Homo sapiens_hsa051430.56526877
85Systemic lupus erythematosus_Homo sapiens_hsa053220.56430023
86Sphingolipid metabolism_Homo sapiens_hsa006000.55975770
87Vibrio cholerae infection_Homo sapiens_hsa051100.55120650
88Platelet activation_Homo sapiens_hsa046110.54559799
89HIF-1 signaling pathway_Homo sapiens_hsa040660.53126566
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49267107
91FoxO signaling pathway_Homo sapiens_hsa040680.45208790
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43668085
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43600121
94GnRH signaling pathway_Homo sapiens_hsa049120.42564399
95Small cell lung cancer_Homo sapiens_hsa052220.42053011
96Prostate cancer_Homo sapiens_hsa052150.42023868
97ErbB signaling pathway_Homo sapiens_hsa040120.41936630
98Proteoglycans in cancer_Homo sapiens_hsa052050.40533369
99Colorectal cancer_Homo sapiens_hsa052100.38766163
100Glioma_Homo sapiens_hsa052140.37810770

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »