C6ORF229

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.98534829
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.87395531
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.72051820
4positive regulation by organism of defense response of other organism involved in symbiotic interact5.72051820
5modulation by symbiont of host immune response (GO:0052553)5.72051820
6positive regulation by symbiont of host defense response (GO:0052509)5.72051820
7modulation by symbiont of host defense response (GO:0052031)5.72051820
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.72051820
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.55895933
10negative regulation of cell killing (GO:0031342)5.55895933
11detection of molecule of bacterial origin (GO:0032490)5.38323456
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.15814220
13positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.94526472
14antigen processing and presentation of endogenous antigen (GO:0019883)4.92316448
15regulation of B cell receptor signaling pathway (GO:0050855)4.90877962
16cellular extravasation (GO:0045123)4.81222254
17neutrophil mediated immunity (GO:0002446)4.74161187
18macrophage activation involved in immune response (GO:0002281)4.68037979
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.60431558
20detection of other organism (GO:0098543)4.54028414
21detection of external biotic stimulus (GO:0098581)4.49479515
22microglial cell activation (GO:0001774)4.37218148
23regulation of gamma-delta T cell activation (GO:0046643)4.30532596
24positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.27703454
25negative regulation of lymphocyte mediated immunity (GO:0002707)4.19744765
26response to interleukin-15 (GO:0070672)4.16254644
27regulation of gamma-delta T cell differentiation (GO:0045586)4.13566658
28regulation of interferon-beta biosynthetic process (GO:0045357)4.12645088
29neutrophil activation involved in immune response (GO:0002283)4.06414371
30myeloid leukocyte mediated immunity (GO:0002444)4.06006421
31negative regulation of interleukin-12 production (GO:0032695)4.05784907
32neutrophil activation (GO:0042119)4.04543781
33detection of bacterium (GO:0016045)4.00079224
34response to host immune response (GO:0052572)3.96146527
35response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.96146527
36negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.90833191
37leukocyte migration involved in inflammatory response (GO:0002523)3.90517372
38detection of biotic stimulus (GO:0009595)3.90305961
39response to peptidoglycan (GO:0032494)3.88669134
40germinal center formation (GO:0002467)3.86172444
41macrophage activation (GO:0042116)3.74336874
42regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.70152631
43respiratory burst (GO:0045730)3.68044311
44cellular response to interleukin-15 (GO:0071350)3.65672714
45positive regulation of B cell differentiation (GO:0045579)3.63400498
46B cell receptor signaling pathway (GO:0050853)3.62717968
47positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.62230463
48positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.60272089
49leukocyte aggregation (GO:0070486)3.59875312
50negative regulation of B cell mediated immunity (GO:0002713)3.58531737
51negative regulation of immunoglobulin mediated immune response (GO:0002890)3.58531737
52response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.54537723
53response to host (GO:0075136)3.54537723
54response to host defenses (GO:0052200)3.54537723
55negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.53620883
56immunoglobulin mediated immune response (GO:0016064)3.52824135
57regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.51870424
58granulocyte activation (GO:0036230)3.49027114
59regulation of B cell differentiation (GO:0045577)3.48156534
60activated T cell proliferation (GO:0050798)3.47030487
61negative regulation of leukocyte mediated immunity (GO:0002704)3.45944511
62positive regulation of granulocyte differentiation (GO:0030854)3.45458513
63cilium or flagellum-dependent cell motility (GO:0001539)3.35749031
64production of molecular mediator involved in inflammatory response (GO:0002532)3.34275337
65myeloid cell activation involved in immune response (GO:0002275)3.32291730
66leukocyte degranulation (GO:0043299)3.23431969
67regulation of oxidative stress-induced neuron death (GO:1903203)3.20859185
68negative regulation of T cell mediated immunity (GO:0002710)3.20715703
69defense response to protozoan (GO:0042832)3.17310512
70T-helper 1 type immune response (GO:0042088)3.17089383
71negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.14950395
72negative regulation of T-helper cell differentiation (GO:0045623)3.14950395
73antigen processing and presentation via MHC class Ib (GO:0002475)3.12494325
74regulation of interleukin-6 biosynthetic process (GO:0045408)3.07094766
75relaxation of smooth muscle (GO:0044557)3.04991964
76negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.03333623
77neutrophil chemotaxis (GO:0030593)3.01255506
78positive regulation of T cell mediated cytotoxicity (GO:0001916)2.97944088
79dendritic cell migration (GO:0036336)2.95417967
80regulation of tolerance induction (GO:0002643)2.93934807
81neutrophil migration (GO:1990266)2.93874538
82negative regulation of interleukin-6 production (GO:0032715)2.90747290
83regulation of mast cell degranulation (GO:0043304)2.90628395
84negative regulation of interleukin-1 production (GO:0032692)2.88094134
85negative T cell selection (GO:0043383)2.86282106
86positive regulation of toll-like receptor signaling pathway (GO:0034123)2.85007004
87positive thymic T cell selection (GO:0045059)2.84881030
88regulation of T cell mediated cytotoxicity (GO:0001914)2.84575078
89natural killer cell activation involved in immune response (GO:0002323)2.83641339
90negative regulation of adaptive immune response (GO:0002820)2.83322135
91negative thymic T cell selection (GO:0045060)2.83035393
92regulation of phosphoprotein phosphatase activity (GO:0043666)2.82476653
93regulation of T-helper 2 cell differentiation (GO:0045628)2.81413101
94positive regulation of tolerance induction (GO:0002645)2.80653775
95regulation of mast cell activation (GO:0033003)2.79966588
96tolerance induction (GO:0002507)2.78305044
97B cell mediated immunity (GO:0019724)2.77910145
98I-kappaB phosphorylation (GO:0007252)2.76910369
99regulation of myeloid leukocyte mediated immunity (GO:0002886)2.74910259
100positive regulation of catecholamine secretion (GO:0033605)2.74828771

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.37326069
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.80382754
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.66676478
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.56407308
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.26813097
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.94316428
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.84560803
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.80253458
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.80126577
10RUNX_20019798_ChIP-Seq_JUKART_Human2.79239201
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.68467668
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.57868152
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.57743674
14SPI1_23547873_ChIP-Seq_NB4_Human2.45726226
15VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.34769557
16SPI1_23127762_ChIP-Seq_K562_Human2.17600772
17MYB_26560356_Chip-Seq_TH2_Human2.17354212
18ESR1_20079471_ChIP-ChIP_T-47D_Human2.13131374
19MYB_26560356_Chip-Seq_TH1_Human2.08906729
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07434110
21VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.05121770
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.99491472
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.95832298
24GATA3_27048872_Chip-Seq_THYMUS_Human1.93201798
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.92492860
26SCL_19346495_ChIP-Seq_HPC-7_Human1.79464213
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.77722979
28GATA3_26560356_Chip-Seq_TH2_Human1.77622619
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.69848021
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.66635693
31VDR_24787735_ChIP-Seq_THP-1_Human1.65373598
32VDR_24763502_ChIP-Seq_THP-1_Human1.64886059
33UTX_26944678_Chip-Seq_JUKART_Human1.64090492
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.58256634
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.54115995
36MAF_26560356_Chip-Seq_TH1_Human1.52340513
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48635837
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.46459562
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.39105286
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.37303935
41IGF1R_20145208_ChIP-Seq_DFB_Human1.37020709
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.36526108
43PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32987189
44MAF_26560356_Chip-Seq_TH2_Human1.32743041
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30513473
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26765032
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26765032
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.25356008
49ER_23166858_ChIP-Seq_MCF-7_Human1.24944633
50VDR_21846776_ChIP-Seq_THP-1_Human1.22707194
51SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21035124
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.13161273
53BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11617092
54RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.10895184
55GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07764827
56Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06801119
57STAT1_20625510_ChIP-Seq_HELA_Human1.06598991
58CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06516270
59PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06400947
60GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02855080
61GATA3_26560356_Chip-Seq_TH1_Human1.02406833
62SMRT_27268052_Chip-Seq_Bcells_Human0.97890071
63OCT1_27270436_Chip-Seq_PROSTATE_Human0.96091020
64BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96043387
65TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95959418
66GATA1_19941827_ChIP-Seq_MEL_Mouse0.95659223
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95481835
68CBP_20019798_ChIP-Seq_JUKART_Human0.95481835
69PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94443839
70KDM2B_26808549_Chip-Seq_DND41_Human0.92571286
71BCL6_27268052_Chip-Seq_Bcells_Human0.92559581
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92398746
73NANOG_20526341_ChIP-Seq_ESCs_Human0.91688922
74GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.90469573
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90154673
76PU_27001747_Chip-Seq_BMDM_Mouse0.88062668
77RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.87484152
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87363521
79KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86912161
80BCAT_22108803_ChIP-Seq_LS180_Human0.86151178
81TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.84992098
82BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.83371576
83GATA2_22383799_ChIP-Seq_G1ME_Mouse0.82135944
84CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82135349
85CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81891373
86PRDM14_20953172_ChIP-Seq_ESCs_Human0.80986175
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80808914
88PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.79676199
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79456300
90P300_27268052_Chip-Seq_Bcells_Human0.79438921
91SPI1_20517297_ChIP-Seq_HL60_Human0.79148370
92FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78989194
93TCF7_22412390_ChIP-Seq_EML_Mouse0.76626695
94OCT4_20526341_ChIP-Seq_ESCs_Human0.75964403
95RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75174516
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75167633
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.75162025
98PU.1_20513432_ChIP-Seq_Bcells_Mouse0.74856058
99CIITA_25753668_ChIP-Seq_RAJI_Human0.74107890
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73116794

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.38975509
2MP0001835_abnormal_antigen_presentation3.98669874
3MP0003436_decreased_susceptibility_to3.53482706
4MP0003303_peritoneal_inflammation3.10159581
5MP0002132_abnormal_respiratory_system2.99893595
6MP0001800_abnormal_humoral_immune2.82975856
7MP0005410_abnormal_fertilization2.79889063
8MP0002419_abnormal_innate_immunity2.72712210
9MP0008004_abnormal_stomach_pH2.71186534
10MP0009785_altered_susceptibility_to2.58111328
11MP0005025_abnormal_response_to2.54886151
12MP0000015_abnormal_ear_pigmentation2.52821000
13MP0002723_abnormal_immune_serum2.46954027
14MP0002420_abnormal_adaptive_immunity2.44777791
15MP0005000_abnormal_immune_tolerance2.42950800
16MP0001819_abnormal_immune_cell2.42537902
17MP0005671_abnormal_response_to2.37339591
18MP0002452_abnormal_antigen_presenting2.33802828
19MP0005075_abnormal_melanosome_morpholog2.27281244
20MP0000685_abnormal_immune_system2.21242422
21MP0008260_abnormal_autophagy2.21027235
22MP0005387_immune_system_phenotype2.17671645
23MP0001790_abnormal_immune_system2.17671645
24MP0003763_abnormal_thymus_physiology2.17575109
25MP0004381_abnormal_hair_follicle2.15270330
26MP0000465_gastrointestinal_hemorrhage2.03653203
27MP0002277_abnormal_respiratory_mucosa1.94917850
28MP0003806_abnormal_nucleotide_metabolis1.93870265
29MP0000569_abnormal_digit_pigmentation1.90612475
30MP0002405_respiratory_system_inflammati1.89252338
31MP0002398_abnormal_bone_marrow1.84744307
32MP0003172_abnormal_lysosome_physiology1.80531166
33MP0000716_abnormal_immune_system1.78121110
34MP0005464_abnormal_platelet_physiology1.77171028
35MP0003828_pulmonary_edema1.69913840
36MP0006082_CNS_inflammation1.69012752
37MP0004883_abnormal_blood_vessel1.64264924
38MP0001533_abnormal_skeleton_physiology1.62312740
39MP0002148_abnormal_hypersensitivity_rea1.59200764
40MP0001845_abnormal_inflammatory_respons1.59174293
41MP0003300_gastrointestinal_ulcer1.52478324
42MP0000689_abnormal_spleen_morphology1.50030171
43MP0005451_abnormal_body_composition1.48455175
44MP0002396_abnormal_hematopoietic_system1.47599284
45MP0002722_abnormal_immune_system1.47208666
46MP0001986_abnormal_taste_sensitivity1.46023495
47MP0010155_abnormal_intestine_physiology1.44451569
48MP0003866_abnormal_defecation1.44285777
49MP0003045_fibrosis1.39006257
50MP0000703_abnormal_thymus_morphology1.38368370
51MP0009764_decreased_sensitivity_to1.37920349
52MP0002429_abnormal_blood_cell1.35580670
53MP0002166_altered_tumor_susceptibility1.13399088
54MP0003191_abnormal_cellular_cholesterol1.10851097
55MP0008469_abnormal_protein_level1.10324892
56MP0004947_skin_inflammation1.08943157
57MP0005164_abnormal_response_to1.05144090
58MP0003075_altered_response_to1.04374656
59MP0005174_abnormal_tail_pigmentation1.04002545
60MP0005310_abnormal_salivary_gland0.99934192
61MP0000858_altered_metastatic_potential0.98695549
62MP0001188_hyperpigmentation0.93725858
63MP0004484_altered_response_of0.91724114
64MP0003656_abnormal_erythrocyte_physiolo0.90238414
65MP0002332_abnormal_exercise_endurance0.87236814
66MP0003698_abnormal_male_reproductive0.84661891
67MP0001929_abnormal_gametogenesis0.84153140
68MP0005166_decreased_susceptibility_to0.81000468
69MP0001984_abnormal_olfaction0.79823436
70MP0009333_abnormal_splenocyte_physiolog0.78045743
71MP0002998_abnormal_bone_remodeling0.77295444
72MP0000343_altered_response_to0.76460756
73MP0005376_homeostasis/metabolism_phenot0.73449501
74MP0009278_abnormal_bone_marrow0.72917553
75MP0003183_abnormal_peptide_metabolism0.72915168
76MP0000371_diluted_coat_color0.69574629
77MP0005266_abnormal_metabolism0.66666657
78MP0001663_abnormal_digestive_system0.66134694
79MP0009763_increased_sensitivity_to0.64858792
80MP0002006_tumorigenesis0.62976410
81MP0002928_abnormal_bile_duct0.61838000
82MP0004808_abnormal_hematopoietic_stem0.61726058
83MP0002009_preneoplasia0.61303983
84MP0002095_abnormal_skin_pigmentation0.61024435
85MP0005397_hematopoietic_system_phenotyp0.60690606
86MP0001545_abnormal_hematopoietic_system0.60690606
87MP0001529_abnormal_vocalization0.58730141
88MP0004084_abnormal_cardiac_muscle0.58320594
89MP0008995_early_reproductive_senescence0.58152420
90MP0001664_abnormal_digestion0.57846682
91MP0008874_decreased_physiological_sensi0.56828806
92MP0001851_eye_inflammation0.56645455
93MP0000249_abnormal_blood_vessel0.53262026
94MP0009765_abnormal_xenobiotic_induced0.52951122
95MP0003221_abnormal_cardiomyocyte_apopto0.52734370
96MP0003878_abnormal_ear_physiology0.52711392
97MP0005377_hearing/vestibular/ear_phenot0.52711392
98MP0002019_abnormal_tumor_incidence0.48595027
99MP0002693_abnormal_pancreas_physiology0.48460763
100MP0005058_abnormal_lysosome_morphology0.48453175

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)5.61975053
2Retrobulbar optic neuritis (HP:0100654)5.59634843
3Optic neuritis (HP:0100653)5.59634843
4Orchitis (HP:0100796)5.50245796
5Recurrent abscess formation (HP:0002722)5.37073933
6Recurrent bacterial skin infections (HP:0005406)5.31802094
7Eczematoid dermatitis (HP:0000976)5.23332620
8Stomatitis (HP:0010280)4.47044333
9Gastrointestinal infarctions (HP:0005244)4.38369059
10Keratoconjunctivitis sicca (HP:0001097)4.13723141
11Elevated erythrocyte sedimentation rate (HP:0003565)4.11514402
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.96511706
13Absent/shortened dynein arms (HP:0200106)3.96511706
14Recurrent gram-negative bacterial infections (HP:0005420)3.87255294
15Keratoconjunctivitis (HP:0001096)3.78241544
16Encephalitis (HP:0002383)3.73893133
17Chronic obstructive pulmonary disease (HP:0006510)3.69471107
18Obstructive lung disease (HP:0006536)3.69471107
19Meningitis (HP:0001287)3.67598084
20Recurrent fungal infections (HP:0002841)3.67463067
21Abnormality of macrophages (HP:0004311)3.65619127
22Mediastinal lymphadenopathy (HP:0100721)3.53016205
23Recurrent skin infections (HP:0001581)3.38871556
24Abnormal delayed hypersensitivity skin test (HP:0002963)3.33884263
25Vasculitis (HP:0002633)3.24001802
26Inflammation of the large intestine (HP:0002037)3.17747051
27Hemoptysis (HP:0002105)3.14623113
28Gingivitis (HP:0000230)3.13583030
29Recurrent cutaneous fungal infections (HP:0011370)3.11500767
30Chronic mucocutaneous candidiasis (HP:0002728)3.11500767
31Chest pain (HP:0100749)3.08922731
32Abnormal ciliary motility (HP:0012262)3.08032435
33Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.04934304
34Resting tremor (HP:0002322)3.04723651
35T lymphocytopenia (HP:0005403)3.03657632
36Spontaneous hematomas (HP:0007420)3.03275766
37Arterial thrombosis (HP:0004420)3.01221452
38Abnormality of T cell number (HP:0011839)3.01010144
39Colitis (HP:0002583)2.96764092
40Gastrointestinal inflammation (HP:0004386)2.95495481
41Urticaria (HP:0001025)2.95007975
42Anorexia (HP:0002039)2.94025865
43Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.91443160
44Abnormal respiratory motile cilium physiology (HP:0012261)2.86969193
45Recurrent sinusitis (HP:0011108)2.86550505
46Nasal polyposis (HP:0100582)2.75467384
47Prolonged bleeding time (HP:0003010)2.74682865
48Postural instability (HP:0002172)2.73473168
49Peritonitis (HP:0002586)2.71871367
50Abnormal respiratory epithelium morphology (HP:0012253)2.71023855
51Abnormal respiratory motile cilium morphology (HP:0005938)2.71023855
52Pulmonary embolism (HP:0002204)2.69794916
53Pulmonary infiltrates (HP:0002113)2.66669864
54Gingival bleeding (HP:0000225)2.61904860
55Gangrene (HP:0100758)2.60569155
56Panhypogammaglobulinemia (HP:0003139)2.58316765
57Leukocytosis (HP:0001974)2.51598972
58Acute hepatic failure (HP:0006554)2.47636652
59Abnormality of T cells (HP:0002843)2.42956185
60Abnormality of the columella (HP:0009929)2.42094794
61IgM deficiency (HP:0002850)2.40427149
62Polyneuropathy (HP:0001271)2.40301429
63Increased IgE level (HP:0003212)2.36274591
64Pustule (HP:0200039)2.35892317
65Granulocytopenia (HP:0001913)2.34726498
66Abnormality of the pleura (HP:0002103)2.32590219
67Hypochromic anemia (HP:0001931)2.31966530
68Chronic otitis media (HP:0000389)2.30537213
69Abnormality of the endocardium (HP:0004306)2.28839502
70Hypochromic microcytic anemia (HP:0004840)2.23970390
71Eosinophilia (HP:0001880)2.22429547
72Episodic fever (HP:0001954)2.21358361
73Epistaxis (HP:0000421)2.20714160
74Bronchiectasis (HP:0002110)2.17947037
75Abnormality of the peritoneum (HP:0002585)2.13790365
76Recurrent viral infections (HP:0004429)2.12814844
77Abnormality of the nasal mucosa (HP:0000433)2.11291287
78Cellulitis (HP:0100658)2.11026893
79Sex reversal (HP:0012245)2.03490337
80Abnormal sex determination (HP:0012244)2.03490337
81Facial diplegia (HP:0001349)2.01978059
82Recurrent bronchitis (HP:0002837)2.00238139
83Keratitis (HP:0000491)1.99678089
84Microcytic anemia (HP:0001935)1.96020388
85Osteomyelitis (HP:0002754)1.95271132
86Papilledema (HP:0001085)1.93536422
87Sepsis (HP:0100806)1.93043533
88Abnormality of T cell physiology (HP:0011840)1.89861323
89Ocular albinism (HP:0001107)1.88816881
90Glomerulopathy (HP:0100820)1.88310643
91Lymphopenia (HP:0001888)1.86245821
92Abnormality of eosinophils (HP:0001879)1.86235815
93Viral hepatitis (HP:0006562)1.85377189
94Chronic sinusitis (HP:0011109)1.83995148
95Hypoplasia of the uterus (HP:0000013)1.83835201
96Stomach cancer (HP:0012126)1.81963823
97Vertigo (HP:0002321)1.77780278
98Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74837378
99Abnormality of cells of the lymphoid lineage (HP:0012140)1.73400105
100Amaurosis fugax (HP:0100576)1.72531577

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK14.27207307
2RIPK43.83867439
3TAOK33.34257737
4MARK33.33449997
5MAP4K13.09038104
6IRAK43.02288548
7FES2.73574230
8BLK2.70583295
9STK162.46724518
10CSK2.27897546
11MAP2K32.22125568
12TYK22.21136615
13TXK2.17069827
14GRK62.10314790
15EPHB12.03468200
16HCK1.90992788
17TNK21.89473154
18BTK1.85216024
19KSR21.78375808
20SYK1.71354613
21ZAP701.65827040
22JAK21.58244743
23IKBKE1.55664125
24FGR1.52964684
25TAOK11.39971428
26TLK11.39959051
27IRAK11.35034710
28PIK3CG1.28768979
29ITK1.28399054
30JAK31.27793940
31FRK1.21534915
32IRAK21.20819147
33LYN1.20488568
34MAP3K61.20262879
35MAP3K131.20180337
36MAP3K11.19111178
37MAP3K141.16606341
38MAP3K31.12509220
39LCK1.04759914
40TEC1.04136474
41ZAK1.04065509
42RAF11.03835304
43STK381.03554451
44MAP3K50.96406659
45JAK10.90455879
46ERN10.90236133
47LRRK20.89980955
48KIT0.88195951
49KSR10.86239494
50PRKCQ0.83817869
51RPS6KA50.83539008
52MARK20.81128656
53MAP2K60.76584494
54SIK20.74198002
55MAP3K20.74000605
56CSF1R0.73178361
57PTK2B0.72864207
58MAP3K110.70533770
59MAPK120.70312524
60YES10.69713538
61MAP3K70.69585905
62PDK10.68870810
63PAK30.67394417
64MAP2K40.66085246
65CDK120.65871991
66MATK0.59976700
67RET0.59865083
68TBK10.59241530
69BRD40.58648544
70FGFR30.58303955
71PIM10.55796492
72STK110.52249609
73PDPK10.51942932
74CDC42BPA0.48105986
75PRKCZ0.47276391
76BMPR20.45857115
77FYN0.45762100
78DAPK20.45368700
79WNK10.44737585
80IKBKB0.42751244
81NLK0.42029471
82MAPK70.40938128
83STK100.39988763
84EGFR0.39203092
85SIK30.38242418
86SGK20.37150057
87SGK2230.36990792
88SGK4940.36990792
89MAP4K20.35908898
90EEF2K0.33848433
91MAPKAPK30.33625779
92PTK60.33269905
93DYRK1A0.30255500
94CAMKK20.29814607
95ERBB30.29239157
96CAMK40.28180942
97PRKAA20.28068306
98PRKD20.28001777
99ADRBK20.27406031
100OXSR10.26675471

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.30225338
2Staphylococcus aureus infection_Homo sapiens_hsa051502.78464276
3Osteoclast differentiation_Homo sapiens_hsa043802.65534274
4Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.61742806
5Graft-versus-host disease_Homo sapiens_hsa053322.52289880
6Allograft rejection_Homo sapiens_hsa053302.48880239
7Phagosome_Homo sapiens_hsa041452.48699632
8Autoimmune thyroid disease_Homo sapiens_hsa053202.38188227
9Tuberculosis_Homo sapiens_hsa051522.29499631
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.16561580
11B cell receptor signaling pathway_Homo sapiens_hsa046622.14782739
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.07703597
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.04115815
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.88065398
15Type I diabetes mellitus_Homo sapiens_hsa049401.86626317
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.84740775
17Primary immunodeficiency_Homo sapiens_hsa053401.84144223
18Measles_Homo sapiens_hsa051621.78279201
19Apoptosis_Homo sapiens_hsa042101.73504845
20T cell receptor signaling pathway_Homo sapiens_hsa046601.65576786
21Toxoplasmosis_Homo sapiens_hsa051451.55493629
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.52878638
23Hematopoietic cell lineage_Homo sapiens_hsa046401.50637862
24Asthma_Homo sapiens_hsa053101.45158716
25Influenza A_Homo sapiens_hsa051641.45138376
26Antigen processing and presentation_Homo sapiens_hsa046121.41748901
27Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.40759900
28Legionellosis_Homo sapiens_hsa051341.40194984
29Herpes simplex infection_Homo sapiens_hsa051681.39975931
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.39075586
31Chemokine signaling pathway_Homo sapiens_hsa040621.38991948
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.38198918
33Malaria_Homo sapiens_hsa051441.36917103
34Gap junction_Homo sapiens_hsa045401.36805407
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.35332114
36Viral myocarditis_Homo sapiens_hsa054161.28264005
37Acute myeloid leukemia_Homo sapiens_hsa052211.27090738
38Rheumatoid arthritis_Homo sapiens_hsa053231.21094856
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.18428238
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13317892
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12247641
42Regulation of autophagy_Homo sapiens_hsa041401.09170419
43TNF signaling pathway_Homo sapiens_hsa046681.08087773
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05232172
45Non-small cell lung cancer_Homo sapiens_hsa052231.03279072
46Dorso-ventral axis formation_Homo sapiens_hsa043201.00278413
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97854841
48Hepatitis B_Homo sapiens_hsa051610.97663402
49Systemic lupus erythematosus_Homo sapiens_hsa053220.96459225
50Platelet activation_Homo sapiens_hsa046110.96331502
51Choline metabolism in cancer_Homo sapiens_hsa052310.84593672
52Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84513625
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.83819220
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83442990
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82547074
56VEGF signaling pathway_Homo sapiens_hsa043700.80283413
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.80173451
58Olfactory transduction_Homo sapiens_hsa047400.77182855
59Hepatitis C_Homo sapiens_hsa051600.75515477
60FoxO signaling pathway_Homo sapiens_hsa040680.70139584
61Shigellosis_Homo sapiens_hsa051310.67585833
62Inositol phosphate metabolism_Homo sapiens_hsa005620.65940298
63Collecting duct acid secretion_Homo sapiens_hsa049660.65330131
64Prolactin signaling pathway_Homo sapiens_hsa049170.65085088
65Endometrial cancer_Homo sapiens_hsa052130.64777579
66Endocytosis_Homo sapiens_hsa041440.63437676
67African trypanosomiasis_Homo sapiens_hsa051430.62110301
68Renal cell carcinoma_Homo sapiens_hsa052110.59991399
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.59383998
70mTOR signaling pathway_Homo sapiens_hsa041500.57274451
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57238629
72Pancreatic cancer_Homo sapiens_hsa052120.56162203
73Viral carcinogenesis_Homo sapiens_hsa052030.54569758
74Pertussis_Homo sapiens_hsa051330.54471769
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53234011
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.50764479
77Epstein-Barr virus infection_Homo sapiens_hsa051690.48914208
78Nitrogen metabolism_Homo sapiens_hsa009100.44433420
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.43855329
80Salmonella infection_Homo sapiens_hsa051320.43575662
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42462366
82Type II diabetes mellitus_Homo sapiens_hsa049300.41439119
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41118184
84Alcoholism_Homo sapiens_hsa050340.40489610
85MAPK signaling pathway_Homo sapiens_hsa040100.39087358
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37783649
87Notch signaling pathway_Homo sapiens_hsa043300.35187618
88Chronic myeloid leukemia_Homo sapiens_hsa052200.33986590
89Oxytocin signaling pathway_Homo sapiens_hsa049210.31332471
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30437405
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27823071
92Synaptic vesicle cycle_Homo sapiens_hsa047210.27393380
93Hedgehog signaling pathway_Homo sapiens_hsa043400.27339564
94HIF-1 signaling pathway_Homo sapiens_hsa040660.26466137
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.25922363
96Arachidonic acid metabolism_Homo sapiens_hsa005900.23215681
97Lysosome_Homo sapiens_hsa041420.23076039
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22884004
99Circadian rhythm_Homo sapiens_hsa047100.22719280
100ABC transporters_Homo sapiens_hsa020100.22718757

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