C6ORF226

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell aging (GO:0090344)8.69271618
2cellular response to ATP (GO:0071318)8.46491839
3regulation of skeletal muscle contraction (GO:0014819)8.39280462
4GDP-mannose metabolic process (GO:0019673)7.89648789
5DNA strand renaturation (GO:0000733)7.88879709
6regulation of synapse structural plasticity (GO:0051823)7.00390896
7adenosine receptor signaling pathway (GO:0001973)6.95672397
8mitotic cell cycle arrest (GO:0071850)6.39204934
9G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)6.37874143
10meiotic chromosome segregation (GO:0045132)6.35275865
11purinergic nucleotide receptor signaling pathway (GO:0035590)6.27230317
12protein carboxylation (GO:0018214)6.22584582
13peptidyl-glutamic acid carboxylation (GO:0017187)6.22584582
14lens fiber cell differentiation (GO:0070306)5.94835245
15rRNA methylation (GO:0031167)5.67003268
16regulation of cytokine production involved in inflammatory response (GO:1900015)5.43141061
17rRNA modification (GO:0000154)5.40601155
18transepithelial transport (GO:0070633)5.35785928
19detection of light stimulus involved in sensory perception (GO:0050962)5.29075143
20detection of light stimulus involved in visual perception (GO:0050908)5.29075143
21negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.91718880
22behavioral response to nicotine (GO:0035095)4.91200391
23response to ATP (GO:0033198)4.85239120
24positive regulation of heat generation (GO:0031652)4.64674989
25purine ribonucleotide transport (GO:0015868)4.61503378
26estrogen biosynthetic process (GO:0006703)4.61218845
27nucleotide transmembrane transport (GO:1901679)4.60943359
28purinergic receptor signaling pathway (GO:0035587)4.59321426
29adenine nucleotide transport (GO:0051503)4.56899878
30nucleoside transmembrane transport (GO:1901642)4.49063352
31sensory perception of taste (GO:0050909)4.44556069
32positive regulation of protein kinase C signaling (GO:0090037)4.32764924
33phosphatidylglycerol biosynthetic process (GO:0006655)4.29808027
34melanin biosynthetic process (GO:0042438)4.19607905
35regulation of protein kinase A signaling (GO:0010738)4.08734309
36regulation of cell aging (GO:0090342)4.03648691
37purine deoxyribonucleotide catabolic process (GO:0009155)3.83755399
38sulfur amino acid catabolic process (GO:0000098)3.82049738
39G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.82019371
40secondary metabolite biosynthetic process (GO:0044550)3.80171221
41urinary tract smooth muscle contraction (GO:0014848)3.78219851
42respiratory chain complex IV assembly (GO:0008535)3.77817875
43grooming behavior (GO:0007625)3.75128802
44base-excision repair, AP site formation (GO:0006285)3.74695171
45dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.73367695
46melanin metabolic process (GO:0006582)3.70274961
47cellular anion homeostasis (GO:0030002)3.67820752
48peptidyl-glutamic acid modification (GO:0018200)3.65686072
49peristalsis (GO:0030432)3.62899631
50nucleotide-sugar biosynthetic process (GO:0009226)3.59179294
51regulation of heat generation (GO:0031650)3.57265500
52UV protection (GO:0009650)3.55280172
53sialylation (GO:0097503)3.53169611
54regulation of phospholipid biosynthetic process (GO:0071071)3.44250260
55purine nucleotide transport (GO:0015865)3.44047605
56phosphate ion homeostasis (GO:0055062)3.42515532
57trivalent inorganic anion homeostasis (GO:0072506)3.42515532
58granulocyte differentiation (GO:0030851)3.41945166
59cardiolipin metabolic process (GO:0032048)3.41277171
60cytochrome complex assembly (GO:0017004)3.36579951
61sphingomyelin metabolic process (GO:0006684)3.35564280
62deoxyribonucleotide catabolic process (GO:0009264)3.33339891
63protein insertion into membrane (GO:0051205)3.31562183
64cilium or flagellum-dependent cell motility (GO:0001539)3.30327483
65negative regulation of interleukin-8 production (GO:0032717)3.29248063
66neuromuscular synaptic transmission (GO:0007274)3.23791656
67positive regulation of TOR signaling (GO:0032008)3.22551897
68nucleoside transport (GO:0015858)3.22044429
69inositol phosphate dephosphorylation (GO:0046855)3.20625369
70phosphorylated carbohydrate dephosphorylation (GO:0046838)3.20625369
71purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.20144918
723-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.20144918
73pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.19151987
74tRNA modification (GO:0006400)3.18978942
75iron-sulfur cluster assembly (GO:0016226)3.15951856
76metallo-sulfur cluster assembly (GO:0031163)3.15951856
77response to gravity (GO:0009629)3.14913380
78deoxyribose phosphate catabolic process (GO:0046386)3.11523034
79piRNA metabolic process (GO:0034587)3.10828989
80activation of adenylate cyclase activity (GO:0007190)3.09882201
81sex determination (GO:0007530)3.09263031
82protein K11-linked ubiquitination (GO:0070979)3.08349596
83interferon-gamma production (GO:0032609)3.03389264
84L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.99594207
85preassembly of GPI anchor in ER membrane (GO:0016254)2.99538300
86type B pancreatic cell proliferation (GO:0044342)2.95919377
87DNA replication checkpoint (GO:0000076)2.93497769
88regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.92282644
89regulation of feeding behavior (GO:0060259)2.91687317
90positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.89332228
91gonadal mesoderm development (GO:0007506)2.84456059
92iron coordination entity transport (GO:1901678)2.84102654
93DNA deamination (GO:0045006)2.83907948
94inositol phosphate catabolic process (GO:0071545)2.82328372
95mannosylation (GO:0097502)2.79719239
96purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.77909909
97ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.77909909
98nucleoside bisphosphate biosynthetic process (GO:0033866)2.77909909
99phosphatidylethanolamine biosynthetic process (GO:0006646)2.75498098
100C-terminal protein lipidation (GO:0006501)2.75027540

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.88685690
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.22785091
3* P68_20966046_ChIP-Seq_HELA_Human3.01640274
4CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.95739653
5* XRN2_22483619_ChIP-Seq_HELA_Human2.88533176
6TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.87733459
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.70682589
8* BCL6_27268052_Chip-Seq_Bcells_Human2.55382684
9* LXR_22292898_ChIP-Seq_THP-1_Human2.48399479
10* MAF_26560356_Chip-Seq_TH2_Human2.45028197
11* E2F1_20622854_ChIP-Seq_HELA_Human2.44779124
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39230812
13* BCOR_27268052_Chip-Seq_Bcells_Human2.32829477
14PHF8_20622854_ChIP-Seq_HELA_Human2.31366434
15IKZF1_21737484_ChIP-ChIP_HCT116_Human2.30938015
16CTCF_27219007_Chip-Seq_Bcells_Human2.19816545
17ERG_21242973_ChIP-ChIP_JURKAT_Human2.18113449
18CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.14272338
19DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.13582110
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.13264019
21MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human2.09841881
22RARB_24833708_ChIP-Seq_LIVER_Mouse2.07663609
23TET1_21451524_ChIP-Seq_MESCs_Mouse2.01927051
24DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.99777015
25FOXP1_21924763_ChIP-Seq_HESCs_Human1.99189858
26ELF1_20517297_ChIP-Seq_JURKAT_Human1.88649033
27* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.87195042
28VDR_24763502_ChIP-Seq_THP-1_Human1.87007340
29MAF_26560356_Chip-Seq_TH1_Human1.85533926
30CTCF_27219007_Chip-Seq_ERYTHROID_Human1.85295638
31RXRA_24833708_ChIP-Seq_LIVER_Mouse1.84557407
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.83910124
33CTCF_20526341_ChIP-Seq_ESCs_Human1.81752931
34RARA_24833708_ChIP-Seq_LIVER_Mouse1.81546710
35RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.79651547
36CTCF_21964334_Chip-Seq_Bcells_Human1.77970734
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.77649690
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.74664752
39SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.72515835
40* YY1_22570637_ChIP-Seq_MALME-3M_Human1.71062872
41EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.67955889
42ERA_21632823_ChIP-Seq_H3396_Human1.67447717
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.67131235
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.66142082
45SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.65632207
46RACK7_27058665_Chip-Seq_MCF-7_Human1.64330881
47SRY_22984422_ChIP-ChIP_TESTIS_Rat1.63308995
48SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61769841
49EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61496505
50GABP_19822575_ChIP-Seq_HepG2_Human1.60684404
51SA1_27219007_Chip-Seq_ERYTHROID_Human1.60413094
52UTX_26944678_Chip-Seq_JUKART_Human1.53943042
53CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.53578167
54SMC4_20622854_ChIP-Seq_HELA_Human1.51542623
55BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.51281047
56CIITA_25753668_ChIP-Seq_RAJI_Human1.47540925
57KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.46548979
58SA1_27219007_Chip-Seq_Bcells_Human1.46171673
59CTCF_21964334_ChIP-Seq_BJAB-B_Human1.46038160
60DCP1A_22483619_ChIP-Seq_HELA_Human1.45399026
61FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.42835109
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.41186586
63CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.41145872
64NANOG_20526341_ChIP-Seq_ESCs_Human1.40719839
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.39850407
66TP53_22127205_ChIP-Seq_IMR90_Human1.39407846
67ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.36165001
68ETS1_21867929_ChIP-Seq_TH2_Mouse1.34927882
69TAF2_19829295_ChIP-Seq_ESCs_Human1.33805238
70P300_27268052_Chip-Seq_Bcells_Human1.32489145
71* VDR_23849224_ChIP-Seq_CD4+_Human1.31081771
72PU.1_20513432_ChIP-Seq_Bcells_Mouse1.30702220
73* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27693966
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27504993
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22615227
76E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22546511
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21854316
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21841340
79* P53_21459846_ChIP-Seq_SAOS-2_Human1.21274578
80CTCF_26484167_Chip-Seq_Bcells_Mouse1.20288956
81OCT4_20526341_ChIP-Seq_ESCs_Human1.16840869
82NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.16644749
83CREB1_26743006_Chip-Seq_LNCaP_Human1.16417021
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15278851
85MYC_19829295_ChIP-Seq_ESCs_Human1.14236697
86THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13769592
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.11429149
88MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09551806
89RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08949755
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08736232
91MYC_18358816_ChIP-ChIP_MESCs_Mouse1.08457262
92SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08319516
93HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.07944636
94SMC3_22415368_ChIP-Seq_MEFs_Mouse1.07906662
95KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07276888
96TP53_22573176_ChIP-Seq_HFKS_Human1.07014808
97BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.05847762
98PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.05732706
99KDM2B_26808549_Chip-Seq_DND41_Human1.05019976
100JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.03060859

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation7.35947764
2MP0001986_abnormal_taste_sensitivity6.42352723
3MP0005423_abnormal_somatic_nervous6.13527394
4MP0005174_abnormal_tail_pigmentation5.67821723
5MP0003136_yellow_coat_color5.33827876
6MP0008875_abnormal_xenobiotic_pharmacok3.23370343
7MP0001968_abnormal_touch/_nociception3.22672133
8MP0001188_hyperpigmentation2.95098104
9MP0002638_abnormal_pupillary_reflex2.55366451
10MP0001756_abnormal_urination2.55278092
11MP0005083_abnormal_biliary_tract2.53443472
12MP0002736_abnormal_nociception_after2.47094921
13MP0001502_abnormal_circadian_rhythm2.34128853
14MP0000751_myopathy2.26681533
15MP0002160_abnormal_reproductive_system2.06354515
16MP0005409_darkened_coat_color2.03773942
17MP0000015_abnormal_ear_pigmentation1.99186647
18MP0004381_abnormal_hair_follicle1.90299523
19MP0000750_abnormal_muscle_regeneration1.87055900
20MP0001661_extended_life_span1.85052091
21MP0005551_abnormal_eye_electrophysiolog1.73471137
22MP0005332_abnormal_amino_acid1.61673165
23MP0002735_abnormal_chemical_nociception1.60200810
24MP0000538_abnormal_urinary_bladder1.57408055
25MP0001905_abnormal_dopamine_level1.53152574
26MP0005330_cardiomyopathy1.47054281
27MP0000013_abnormal_adipose_tissue1.44875814
28MP0003806_abnormal_nucleotide_metabolis1.42193758
29MP0005410_abnormal_fertilization1.42035090
30MP0001919_abnormal_reproductive_system1.34490062
31MP0005084_abnormal_gallbladder_morpholo1.29696619
32MP0010386_abnormal_urinary_bladder1.25775057
33MP0005253_abnormal_eye_physiology1.24297290
34MP0004130_abnormal_muscle_cell1.24156441
35MP0002909_abnormal_adrenal_gland1.22599927
36MP0003011_delayed_dark_adaptation1.19736177
37MP0003453_abnormal_keratinocyte_physiol1.14278497
38MP0004019_abnormal_vitamin_homeostasis1.10378801
39MP0001765_abnormal_ion_homeostasis1.10376168
40MP0005389_reproductive_system_phenotype1.09630788
41MP0004043_abnormal_pH_regulation1.08505773
42MP0001970_abnormal_pain_threshold1.08043312
43MP0003137_abnormal_impulse_conducting1.04611818
44MP0005365_abnormal_bile_salt1.02717024
45MP0005584_abnormal_enzyme/coenzyme_acti1.00181126
46MP0005501_abnormal_skin_physiology0.85380265
47MP0002933_joint_inflammation0.84541776
48MP0006276_abnormal_autonomic_nervous0.83836135
49MP0003878_abnormal_ear_physiology0.82474884
50MP0005377_hearing/vestibular/ear_phenot0.82474884
51MP0001664_abnormal_digestion0.82161710
52MP0001324_abnormal_eye_pigmentation0.81958765
53MP0000358_abnormal_cell_content/0.81437609
54MP0006036_abnormal_mitochondrial_physio0.80988330
55MP0003111_abnormal_nucleus_morphology0.79891964
56MP0009643_abnormal_urine_homeostasis0.77530302
57MP0002254_reproductive_system_inflammat0.76940223
58MP0000003_abnormal_adipose_tissue0.76699621
59MP0000367_abnormal_coat/_hair0.71342095
60MP0000470_abnormal_stomach_morphology0.71155841
61MP0004215_abnormal_myocardial_fiber0.69166983
62MP0000747_muscle_weakness0.67142330
63MP0001873_stomach_inflammation0.65609832
64MP0002928_abnormal_bile_duct0.57398107
65MP0002210_abnormal_sex_determination0.57209838
66MP0004142_abnormal_muscle_tone0.55360628
67MP0003448_altered_tumor_morphology0.54416347
68MP0006082_CNS_inflammation0.53319340
69MP0002136_abnormal_kidney_physiology0.52082620
70MP0001958_emphysema0.52020456
71MP0005058_abnormal_lysosome_morphology0.51901831
72MP0001191_abnormal_skin_condition0.50892055
73MP0008872_abnormal_physiological_respon0.49776895
74MP0002019_abnormal_tumor_incidence0.48988774
75MP0010771_integument_phenotype0.46670404
76MP0002277_abnormal_respiratory_mucosa0.45451789
77MP0002118_abnormal_lipid_homeostasis0.45025652
78MP0005195_abnormal_posterior_eye0.44384371
79MP0002075_abnormal_coat/hair_pigmentati0.42135084
80MP0001764_abnormal_homeostasis0.41574227
81MP0002572_abnormal_emotion/affect_behav0.40979249
82MP0004924_abnormal_behavior0.40420396
83MP0005386_behavior/neurological_phenoty0.40420396
84MP0000026_abnormal_inner_ear0.39947063
85MP0005257_abnormal_intraocular_pressure0.39544131
86MP0005448_abnormal_energy_balance0.39522659
87MP0009931_abnormal_skin_appearance0.39363049
88MP0003635_abnormal_synaptic_transmissio0.39337339
89MP0008789_abnormal_olfactory_epithelium0.39169641
90MP0009745_abnormal_behavioral_response0.38713844
91MP0006035_abnormal_mitochondrial_morpho0.38245182
92MP0005535_abnormal_body_temperature0.38080952
93MP0003698_abnormal_male_reproductive0.37992937
94MP0005636_abnormal_mineral_homeostasis0.37332321
95MP0005220_abnormal_exocrine_pancreas0.37189003
96MP0002095_abnormal_skin_pigmentation0.36581478
97MP0009384_cardiac_valve_regurgitation0.35261546
98MP0000230_abnormal_systemic_arterial0.35134010
99MP0008874_decreased_physiological_sensi0.34161595
100MP0003880_abnormal_central_pattern0.34016867

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)6.37032797
2Rib fusion (HP:0000902)6.05733644
3Attenuation of retinal blood vessels (HP:0007843)5.49171223
4Dyschromatopsia (HP:0007641)5.29564799
5Rectovaginal fistula (HP:0000143)5.17644629
6Rectal fistula (HP:0100590)5.17644629
7Mesangial abnormality (HP:0001966)5.10173792
8Poikiloderma (HP:0001029)4.84382318
9Increased hepatocellular lipid droplets (HP:0006565)4.77779056
10Vaginal fistula (HP:0004320)4.67387761
11Congenital stationary night blindness (HP:0007642)4.66741616
12Renal Fanconi syndrome (HP:0001994)4.60665423
13Intestinal fistula (HP:0100819)4.59075172
14Lipid accumulation in hepatocytes (HP:0006561)4.52583770
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.51302726
16Facial diplegia (HP:0001349)4.27846842
17Popliteal pterygium (HP:0009756)4.16350091
18Thin bony cortex (HP:0002753)4.02375440
19Akinesia (HP:0002304)3.99929439
20Abnormality of the intrinsic pathway (HP:0010989)3.97157609
21Annular pancreas (HP:0001734)3.93064459
22Facial hemangioma (HP:0000329)3.80382986
23Bony spicule pigmentary retinopathy (HP:0007737)3.79467697
24Prolonged partial thromboplastin time (HP:0003645)3.75405593
25Decreased electroretinogram (ERG) amplitude (HP:0000654)3.69156128
26Joint hemorrhage (HP:0005261)3.68465364
27Fetal akinesia sequence (HP:0001989)3.66331693
28Chorioretinal atrophy (HP:0000533)3.62545569
29Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.54630485
30Aplasia of the musculature (HP:0100854)3.50224513
31Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.48618578
32Choroideremia (HP:0001139)3.45022796
33Increased intramyocellular lipid droplets (HP:0012240)3.44434776
34Hypoalbuminemia (HP:0003073)3.40360506
35Abnormal albumin level (HP:0012116)3.40360506
36Turricephaly (HP:0000262)3.34629290
37Ulnar bowing (HP:0003031)3.30828574
38Squamous cell carcinoma (HP:0002860)3.28256172
39Delayed epiphyseal ossification (HP:0002663)3.26117366
40Exertional dyspnea (HP:0002875)3.25896210
41Decreased central vision (HP:0007663)3.21572725
42Increased muscle lipid content (HP:0009058)3.19466427
43Abnormality of placental membranes (HP:0011409)3.17308018
44Amniotic constriction ring (HP:0009775)3.17308018
45Hemorrhage of the eye (HP:0011885)3.10017168
46Coronal craniosynostosis (HP:0004440)3.01191261
47Atrioventricular block (HP:0001678)2.95052188
48Abnormality of the costochondral junction (HP:0000919)2.94651753
49Patellar aplasia (HP:0006443)2.94550619
50Myotonia (HP:0002486)2.94424256
51Enlarged epiphyses (HP:0010580)2.80822346
52Abnormality of renal resorption (HP:0011038)2.80780912
53Hypophosphatemic rickets (HP:0004912)2.79734543
54Aplasia/Hypoplasia of the patella (HP:0006498)2.77184761
55Anteriorly placed anus (HP:0001545)2.68889915
56Absent thumb (HP:0009777)2.67670917
57Respiratory difficulties (HP:0002880)2.59780433
58Short chin (HP:0000331)2.58349919
59Neonatal respiratory distress (HP:0002643)2.52761754
60Premature graying of hair (HP:0002216)2.48063679
61Abnormal urine phosphate concentration (HP:0012599)2.43228849
62Type 2 muscle fiber atrophy (HP:0003554)2.43177665
63Widely patent fontanelles and sutures (HP:0004492)2.40727981
64Neonatal onset (HP:0003623)2.32789098
65Abnormal drinking behavior (HP:0030082)2.31879586
66Polydipsia (HP:0001959)2.31879586
67Mitochondrial inheritance (HP:0001427)2.31079920
68Muscle fiber atrophy (HP:0100295)2.29001246
69Aplasia/Hypoplasia involving the musculature (HP:0001460)2.28786418
70Joint stiffness (HP:0001387)2.26750727
71Zonular cataract (HP:0010920)2.22568666
72Pendular nystagmus (HP:0012043)2.19711222
73Abnormal epiphyseal ossification (HP:0010656)2.17300550
74Capillary hemangiomas (HP:0005306)2.08612666
75Hypoplasia of the pons (HP:0012110)2.07610827
76Diminished movement (HP:0002374)2.06675654
77Narrow nasal bridge (HP:0000446)2.04140151
78Basal cell carcinoma (HP:0002671)2.02934629
79Choanal stenosis (HP:0000452)2.02825379
80Malignant hyperthermia (HP:0002047)2.01629285
81Abnormality of urine glucose concentration (HP:0011016)2.00759605
82Glycosuria (HP:0003076)2.00759605
83Abnormality of the common coagulation pathway (HP:0010990)2.00230069
84Flat occiput (HP:0005469)1.99190286
85Increased CSF lactate (HP:0002490)1.98768864
86Birth length less than 3rd percentile (HP:0003561)1.95100666
87Male infertility (HP:0003251)1.94477626
88Bowing of the arm (HP:0006488)1.91534527
89Bowed forearm bones (HP:0003956)1.91534527
90Heart block (HP:0012722)1.89026233
91Epiphyseal stippling (HP:0010655)1.88798799
92Hepatocellular necrosis (HP:0001404)1.86752968
93Renal tubular dysfunction (HP:0000124)1.85865994
94Abnormality of the pons (HP:0007361)1.85562231
95Hyperphosphaturia (HP:0003109)1.82721446
96Optic disc pallor (HP:0000543)1.81714865
97Reduced antithrombin III activity (HP:0001976)1.81170976
98Macular degeneration (HP:0000608)1.80056953
99Abnormality of the neuromuscular junction (HP:0003398)1.79926462
100Fatigable weakness (HP:0003473)1.79926462

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK159.72609560
2WNK44.58781101
3MUSK3.56707385
4TESK23.14118565
5TLK12.86806126
6STK162.86697037
7BLK2.56322040
8ZAK2.55459873
9ADRBK22.35605817
10ADRBK11.73314687
11GRK61.67111746
12BCKDK1.66077788
13MAP4K21.57659281
14SIK21.53641833
15TRIM281.51768391
16NUAK11.43925951
17DYRK1B1.34338953
18CCNB11.20148329
19PIM21.15477451
20DYRK21.13200858
21CSK1.12083330
22VRK21.09048257
23MAP3K111.07559405
24IRAK20.99329499
25TBK10.91510251
26DAPK20.88757991
27ZAP700.88104881
28WNK30.86447039
29GRK10.85854398
30CDK150.85630900
31BMPR1B0.85375418
32MAP2K60.83710264
33RPS6KA50.83447838
34CDK11A0.82955452
35CDK180.82458797
36PDK20.82366712
37WNK10.81775331
38DAPK10.81731699
39ACVR1B0.81383957
40TAOK30.80100181
41MAP2K30.79937750
42STK390.78526765
43OXSR10.78190062
44IKBKE0.75421798
45CSNK1G30.75357491
46CAMKK20.73342030
47CDK140.71179234
48PDPK10.71158790
49PAK10.71112079
50IKBKB0.70341754
51ARAF0.69759344
52DYRK30.68910343
53CSNK1A1L0.68369289
54PRKCH0.68307283
55PRKD10.67411788
56AURKA0.67111171
57PINK10.63073110
58MAP4K10.62850372
59NME20.62144058
60LIMK10.62114599
61STK110.56228530
62PRKCQ0.54814059
63VRK10.54514251
64FRK0.54432103
65CSNK1D0.54329334
66CSNK1G20.53973102
67BMX0.52810840
68PLK10.50806592
69MAPK130.50528379
70ERN10.49911758
71TESK10.49441445
72MAP2K70.48453780
73PRKD20.46713693
74CSNK1G10.45829327
75MAPK110.42480727
76FES0.41865351
77TIE10.41203714
78KDR0.41202116
79DAPK30.41148534
80PHKG20.41004152
81PHKG10.41004152
82SIK30.40445407
83ABL20.38295034
84RPS6KA60.37288128
85RPS6KA20.37282050
86CHEK20.36612654
87ATR0.34724354
88PRKCG0.33859795
89PRKACA0.33392242
90PRKCD0.32734200
91LYN0.31081118
92SIK10.30391120
93MAPK120.29402232
94MAPKAPK30.28746260
95TXK0.28118945
96CDK40.27619349
97SYK0.27022391
98PRKCA0.26908494
99TAF10.26889647
100TAOK20.25119578

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001307.09988978
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006047.01152593
3Sulfur relay system_Homo sapiens_hsa041225.17504305
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.40865163
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.26806272
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.87763564
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.61604310
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.45310549
9Fructose and mannose metabolism_Homo sapiens_hsa000511.99719337
10RNA polymerase_Homo sapiens_hsa030201.87218357
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.74509642
12Oxidative phosphorylation_Homo sapiens_hsa001901.66490527
13Circadian rhythm_Homo sapiens_hsa047101.65040385
14Sphingolipid metabolism_Homo sapiens_hsa006001.64839239
15Fanconi anemia pathway_Homo sapiens_hsa034601.55015082
16Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.47531829
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31187954
18Parkinsons disease_Homo sapiens_hsa050121.29830001
19Taste transduction_Homo sapiens_hsa047421.26237559
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25968568
21Phototransduction_Homo sapiens_hsa047441.21680705
22Nicotine addiction_Homo sapiens_hsa050331.20807190
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20460565
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05062932
25Hedgehog signaling pathway_Homo sapiens_hsa043401.01943275
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94215373
27Huntingtons disease_Homo sapiens_hsa050160.92766256
28Chemical carcinogenesis_Homo sapiens_hsa052040.91646807
29Pyrimidine metabolism_Homo sapiens_hsa002400.89992894
30Basal transcription factors_Homo sapiens_hsa030220.88537656
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87131987
32Intestinal immune network for IgA production_Homo sapiens_hsa046720.85806235
33Primary immunodeficiency_Homo sapiens_hsa053400.85158970
34Glutathione metabolism_Homo sapiens_hsa004800.81593608
35Base excision repair_Homo sapiens_hsa034100.80850616
36Alzheimers disease_Homo sapiens_hsa050100.76654116
37Lysosome_Homo sapiens_hsa041420.72018108
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70386755
39Primary bile acid biosynthesis_Homo sapiens_hsa001200.70237573
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69514196
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69034679
42Pyruvate metabolism_Homo sapiens_hsa006200.68128946
43Maturity onset diabetes of the young_Homo sapiens_hsa049500.67534684
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67315117
45Ovarian steroidogenesis_Homo sapiens_hsa049130.67142585
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61824158
47Sulfur metabolism_Homo sapiens_hsa009200.59379568
48Metabolic pathways_Homo sapiens_hsa011000.57897800
49Vitamin digestion and absorption_Homo sapiens_hsa049770.56108927
50Linoleic acid metabolism_Homo sapiens_hsa005910.55907610
51Homologous recombination_Homo sapiens_hsa034400.55606035
52Cocaine addiction_Homo sapiens_hsa050300.55462734
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54084042
54N-Glycan biosynthesis_Homo sapiens_hsa005100.52927247
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.49092534
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48554613
57Purine metabolism_Homo sapiens_hsa002300.48378625
58Cardiac muscle contraction_Homo sapiens_hsa042600.47600826
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.46460453
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44939098
61Calcium signaling pathway_Homo sapiens_hsa040200.44062206
62Proteasome_Homo sapiens_hsa030500.43069365
63Autoimmune thyroid disease_Homo sapiens_hsa053200.41722429
64Allograft rejection_Homo sapiens_hsa053300.41396679
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.40614848
66Peroxisome_Homo sapiens_hsa041460.39893536
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38993527
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37893998
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36574384
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.36343927
71Ribosome_Homo sapiens_hsa030100.34652046
72Asthma_Homo sapiens_hsa053100.33874404
73Regulation of autophagy_Homo sapiens_hsa041400.31635428
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30975530
75Hematopoietic cell lineage_Homo sapiens_hsa046400.30344569
76Alcoholism_Homo sapiens_hsa050340.28700487
77Type I diabetes mellitus_Homo sapiens_hsa049400.27780235
78Fat digestion and absorption_Homo sapiens_hsa049750.27276006
79Morphine addiction_Homo sapiens_hsa050320.27146749
80Graft-versus-host disease_Homo sapiens_hsa053320.21887728
81Nitrogen metabolism_Homo sapiens_hsa009100.21670523
82Glycerolipid metabolism_Homo sapiens_hsa005610.21036461
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19765759
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19258189
85Other glycan degradation_Homo sapiens_hsa005110.18991407
86Rheumatoid arthritis_Homo sapiens_hsa053230.18877766
87Ether lipid metabolism_Homo sapiens_hsa005650.18060865
88Hippo signaling pathway_Homo sapiens_hsa043900.17931101
89Mineral absorption_Homo sapiens_hsa049780.16908273
90One carbon pool by folate_Homo sapiens_hsa006700.15702703
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.15682944
92Endocytosis_Homo sapiens_hsa041440.14445291
93Fatty acid degradation_Homo sapiens_hsa000710.12955165
94RNA degradation_Homo sapiens_hsa030180.09830763
95Arachidonic acid metabolism_Homo sapiens_hsa005900.09758926
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.09533695
97Protein export_Homo sapiens_hsa030600.08675514
98mTOR signaling pathway_Homo sapiens_hsa041500.08172466
99Systemic lupus erythematosus_Homo sapiens_hsa053220.08034819
100Melanogenesis_Homo sapiens_hsa049160.07691237

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