C6ORF223

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.81439889
2urea cycle (GO:0000050)4.63455878
3regulation of apoptotic process involved in morphogenesis (GO:1902337)4.61940088
4T-helper 1 type immune response (GO:0042088)4.57895674
5low-density lipoprotein particle clearance (GO:0034383)4.31681060
6GDP-mannose metabolic process (GO:0019673)4.21920495
7diaphragm development (GO:0060539)4.11285577
8activation of Rac GTPase activity (GO:0032863)4.04678172
9urea metabolic process (GO:0019627)4.03306569
10protein localization to chromosome, centromeric region (GO:0071459)3.90664198
11regulation of spindle checkpoint (GO:0090231)3.88352174
12T cell lineage commitment (GO:0002360)3.85573536
13positive regulation of cell cycle checkpoint (GO:1901978)3.82117646
14citrulline metabolic process (GO:0000052)3.81710588
15regulation of cholesterol homeostasis (GO:2000188)3.78082416
16atrioventricular valve morphogenesis (GO:0003181)3.77741879
17mitotic chromosome condensation (GO:0007076)3.72477315
18innate immune response in mucosa (GO:0002227)3.70135267
19cellular response to arsenic-containing substance (GO:0071243)3.59249124
20nitrogen cycle metabolic process (GO:0071941)3.55720178
21regulation of vitamin D biosynthetic process (GO:0060556)3.54488494
22activation of MAPKKK activity (GO:0000185)3.53541380
23skeletal muscle organ development (GO:0060538)3.47775756
24folic acid metabolic process (GO:0046655)3.46939286
25NIK/NF-kappaB signaling (GO:0038061)3.45106522
26regulation of translational fidelity (GO:0006450)3.44082684
27positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.37832052
28germinal center formation (GO:0002467)3.35125325
29snRNA metabolic process (GO:0016073)3.30850335
30proline biosynthetic process (GO:0006561)3.30010199
31DNA unwinding involved in DNA replication (GO:0006268)3.26431894
32endothelial cell chemotaxis (GO:0035767)3.21020223
33response to laminar fluid shear stress (GO:0034616)3.20821224
34DNA strand elongation involved in DNA replication (GO:0006271)3.20255992
35midgut development (GO:0007494)3.19244858
36mitotic sister chromatid cohesion (GO:0007064)3.18252798
37positive regulation of protein kinase C signaling (GO:0090037)3.11978691
38nuclear envelope reassembly (GO:0031468)3.10706352
39mitotic nuclear envelope reassembly (GO:0007084)3.10706352
40mRNA cleavage (GO:0006379)3.09140570
41antimicrobial humoral response (GO:0019730)3.07562959
42DNA strand elongation (GO:0022616)3.06179692
43positive regulation of p38MAPK cascade (GO:1900745)3.03370167
44proline metabolic process (GO:0006560)3.01501777
45telomere maintenance via semi-conservative replication (GO:0032201)3.00182088
46organ or tissue specific immune response (GO:0002251)2.97158921
47homocysteine metabolic process (GO:0050667)2.96523677
48mucosal immune response (GO:0002385)2.96422485
49ribosomal small subunit biogenesis (GO:0042274)2.95454376
50positive regulation of lipid storage (GO:0010884)2.93813124
51mitochondrial DNA metabolic process (GO:0032042)2.91756857
52negative regulation of gluconeogenesis (GO:0045721)2.90125474
53mitotic sister chromatid segregation (GO:0000070)2.88303735
54tRNA methylation (GO:0030488)2.86779138
55regulation of vitamin metabolic process (GO:0030656)2.85991834
56regulation of chromatin binding (GO:0035561)2.85449403
57embryonic process involved in female pregnancy (GO:0060136)2.84743545
58regulation of triglyceride biosynthetic process (GO:0010866)2.84710719
59antibacterial humoral response (GO:0019731)2.84319243
60regulation of interferon-gamma biosynthetic process (GO:0045072)2.79211284
61chaperone mediated protein folding requiring cofactor (GO:0051085)2.74814635
62positive regulation of vascular permeability (GO:0043117)2.73057697
63modulation by symbiont of host cellular process (GO:0044068)2.71839666
64glutamine family amino acid biosynthetic process (GO:0009084)2.71353617
65COPI coating of Golgi vesicle (GO:0048205)2.70956677
66Golgi transport vesicle coating (GO:0048200)2.70956677
67activation of NF-kappaB-inducing kinase activity (GO:0007250)2.70541247
68surfactant homeostasis (GO:0043129)2.69502465
69regulation of anoikis (GO:2000209)2.69069317
70glucose 6-phosphate metabolic process (GO:0051156)2.68179224
71snRNA processing (GO:0016180)2.66514534
72regulation of cell cycle checkpoint (GO:1901976)2.66029088
73negative regulation of viral release from host cell (GO:1902187)2.63942365
74tricarboxylic acid metabolic process (GO:0072350)2.62179432
75glycolytic process (GO:0006096)2.59855314
76positive regulation of Cdc42 GTPase activity (GO:0043089)2.58859547
77spliceosomal tri-snRNP complex assembly (GO:0000244)2.57394310
78positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.57331495
79DNA replication-dependent nucleosome organization (GO:0034723)2.56617722
80DNA replication-dependent nucleosome assembly (GO:0006335)2.56617722
81meiotic chromosome segregation (GO:0045132)2.55144227
82positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.54991410
83regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.52812037
84lung vasculature development (GO:0060426)2.51925754
85apoptotic process involved in morphogenesis (GO:0060561)2.50511283
86immunoglobulin mediated immune response (GO:0016064)2.48797870
87ncRNA 3-end processing (GO:0043628)2.46381063
88folic acid-containing compound biosynthetic process (GO:0009396)2.45811133
89entrainment of circadian clock by photoperiod (GO:0043153)2.45732062
90regulation of histone H3-K27 methylation (GO:0061085)2.45435071
91mature B cell differentiation involved in immune response (GO:0002313)2.44344786
92rRNA methylation (GO:0031167)2.44316937
93regulation of cholesterol storage (GO:0010885)2.43117293
94response to arsenic-containing substance (GO:0046685)2.41346926
95response to peptidoglycan (GO:0032494)2.41005179
96mitotic nuclear envelope disassembly (GO:0007077)2.40761772
97histone phosphorylation (GO:0016572)2.37909264
98telomere maintenance via recombination (GO:0000722)2.37653451
99DNA replication initiation (GO:0006270)2.36873180
100positive regulation of odontogenesis (GO:0042482)2.35307398

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.22523204
2E2F7_22180533_ChIP-Seq_HELA_Human3.75773070
3TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse3.17073101
4MYC_22102868_ChIP-Seq_BL_Human3.08228824
5ZNF263_19887448_ChIP-Seq_K562_Human3.00593331
6* VDR_21846776_ChIP-Seq_THP-1_Human2.76505240
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.69310094
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.39056202
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.24378359
10DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.16128837
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.03071794
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.02418621
13LXR_22292898_ChIP-Seq_THP-1_Human1.98080347
14E2F4_17652178_ChIP-ChIP_JURKAT_Human1.94632528
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.89238127
16HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.88498083
17XRN2_22483619_ChIP-Seq_HELA_Human1.87766208
18ELK3_25401928_ChIP-Seq_HUVEC_Human1.81072474
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.80849943
20RACK7_27058665_Chip-Seq_MCF-7_Human1.76496042
21MAF_26560356_Chip-Seq_TH1_Human1.75298363
22KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.72588619
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.70553807
24MYC_18358816_ChIP-ChIP_MESCs_Mouse1.65019129
25HIF1A_21447827_ChIP-Seq_MCF-7_Human1.62518618
26MYC_19030024_ChIP-ChIP_MESCs_Mouse1.58490972
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.57330183
28ATF3_27146783_Chip-Seq_COLON_Human1.56205162
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55788584
30DCP1A_22483619_ChIP-Seq_HELA_Human1.53418152
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.53139034
32MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48369363
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.47980160
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46980468
35P68_20966046_ChIP-Seq_HELA_Human1.41209310
36KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.40471914
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.39188296
38UTX_26944678_Chip-Seq_JUKART_Human1.38965445
39MAF_26560356_Chip-Seq_TH2_Human1.37635522
40TCF7_22412390_ChIP-Seq_EML_Mouse1.37318451
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.35962373
42CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35101512
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33285676
44TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.33056513
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30875429
46CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30578975
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.30484616
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30134956
49* VDR_24763502_ChIP-Seq_THP-1_Human1.27659434
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26712283
51SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25983767
52KDM2B_26808549_Chip-Seq_DND41_Human1.25546955
53STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25386051
54ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.25237506
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25132237
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24098175
57CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23517916
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22598695
59NELFA_20434984_ChIP-Seq_ESCs_Mouse1.22154291
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.22067582
61CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19244502
62DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18076678
63UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17901618
64BCOR_27268052_Chip-Seq_Bcells_Human1.17865846
65CREB1_15753290_ChIP-ChIP_HEK293T_Human1.17418769
66SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.14455604
67CIITA_25753668_ChIP-Seq_RAJI_Human1.14405314
68NCOR1_26117541_ChIP-Seq_K562_Human1.13745885
69TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13424506
70CREB1_26743006_Chip-Seq_LNCaP_Human1.12366864
71SMC4_20622854_ChIP-Seq_HELA_Human1.12081856
72CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11878797
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11609023
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09657669
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08578570
76ETS1_20019798_ChIP-Seq_JURKAT_Human1.08291186
77TP53_22127205_ChIP-Seq_IMR90_Human1.07993346
78* UBF1/2_26484160_Chip-Seq_HMECs_Human1.07910853
79TET1_21451524_ChIP-Seq_MESCs_Mouse1.07178026
80TTF2_22483619_ChIP-Seq_HELA_Human1.07058434
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.06414152
82CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06031078
83THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05105880
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04734822
85KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04473840
86KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04015046
87ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03171817
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01522480
89SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.01406212
90CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00390952
91KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00320195
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99581142
93PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99304678
94GABP_19822575_ChIP-Seq_HepG2_Human0.99029825
95CLOCK_20551151_ChIP-Seq_293T_Human0.98115862
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96554247
97BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96387229
98SA1_27219007_Chip-Seq_ERYTHROID_Human0.96252096
99* CTCF_21964334_Chip-Seq_Bcells_Human0.94966645
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.94710510

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005076_abnormal_cell_differentiation3.26718628
2MP0005083_abnormal_biliary_tract3.17813690
3MP0010234_abnormal_vibrissa_follicle3.15389325
4MP0005623_abnormal_meninges_morphology3.11520514
5MP0005451_abnormal_body_composition2.87010294
6MP0004808_abnormal_hematopoietic_stem2.78378917
7MP0002877_abnormal_melanocyte_morpholog2.69200972
8MP0010094_abnormal_chromosome_stability2.65425757
9MP0003111_abnormal_nucleus_morphology2.62682895
10MP0003693_abnormal_embryo_hatching2.54594240
11MP0000490_abnormal_crypts_of2.50233416
12MP0000685_abnormal_immune_system2.43464383
13MP0002139_abnormal_hepatobiliary_system2.39539754
14MP0009840_abnormal_foam_cell2.25689092
15MP0010030_abnormal_orbit_morphology2.18104480
16MP0003077_abnormal_cell_cycle2.16816469
17MP0003763_abnormal_thymus_physiology2.01139081
18MP0003303_peritoneal_inflammation1.99282777
19MP0004233_abnormal_muscle_weight1.98275941
20MP0004957_abnormal_blastocyst_morpholog1.97152669
21MP0003705_abnormal_hypodermis_morpholog1.84011402
22MP0003453_abnormal_keratinocyte_physiol1.83756465
23MP0002396_abnormal_hematopoietic_system1.81783854
24MP0008057_abnormal_DNA_replication1.81453265
25MP0001790_abnormal_immune_system1.62464936
26MP0005387_immune_system_phenotype1.62464936
27MP0004947_skin_inflammation1.61245836
28MP0001661_extended_life_span1.60258704
29MP0004185_abnormal_adipocyte_glucose1.59979941
30MP0001800_abnormal_humoral_immune1.58847602
31MP0005501_abnormal_skin_physiology1.51260559
32MP0010352_gastrointestinal_tract_polyps1.48829709
33MP0005000_abnormal_immune_tolerance1.45563565
34MP0001849_ear_inflammation1.39343683
35MP0008058_abnormal_DNA_repair1.39123352
36MP0000350_abnormal_cell_proliferation1.38641697
37MP0000003_abnormal_adipose_tissue1.37021041
38MP0009333_abnormal_splenocyte_physiolog1.35022416
39MP0002398_abnormal_bone_marrow1.34779890
40MP0003123_paternal_imprinting1.34673845
41MP0003436_decreased_susceptibility_to1.33329798
42MP0001348_abnormal_lacrimal_gland1.31488641
43MP0002452_abnormal_antigen_presenting1.31310645
44MP0008007_abnormal_cellular_replicative1.26419208
45MP0004264_abnormal_extraembryonic_tissu1.26103573
46MP0002796_impaired_skin_barrier1.24838582
47MP0002723_abnormal_immune_serum1.24397656
48MP0002019_abnormal_tumor_incidence1.21057468
49MP0010307_abnormal_tumor_latency1.20423645
50MP0005666_abnormal_adipose_tissue1.18960504
51MP0002722_abnormal_immune_system1.18515491
52MP0002166_altered_tumor_susceptibility1.14876696
53MP0010155_abnormal_intestine_physiology1.14572333
54MP0001835_abnormal_antigen_presentation1.11229822
55MP0003091_abnormal_cell_migration1.11111949
56MP0002006_tumorigenesis1.09828168
57MP0002429_abnormal_blood_cell1.09558400
58MP0008932_abnormal_embryonic_tissue1.09498392
59MP0000313_abnormal_cell_death1.08735574
60MP0005621_abnormal_cell_physiology1.08478204
61MP0003959_abnormal_lean_body1.08216079
62MP0005375_adipose_tissue_phenotype1.07863855
63MP0000716_abnormal_immune_system1.04684893
64MP0002970_abnormal_white_adipose1.03762882
65MP0000858_altered_metastatic_potential1.03742841
66MP0000689_abnormal_spleen_morphology1.02729976
67MP0002089_abnormal_postnatal_growth/wei1.02029035
68MP0002420_abnormal_adaptive_immunity1.01233205
69MP0009278_abnormal_bone_marrow1.00761821
70MP0001819_abnormal_immune_cell1.00514893
71MP0001216_abnormal_epidermal_layer0.99971903
72MP0000703_abnormal_thymus_morphology0.98983147
73MP0005671_abnormal_response_to0.94231004
74MP0005332_abnormal_amino_acid0.92866041
75MP0002060_abnormal_skin_morphology0.92649119
76MP0009931_abnormal_skin_appearance0.92429276
77MP0000609_abnormal_liver_physiology0.91590226
78MP0003300_gastrointestinal_ulcer0.91257315
79MP0003984_embryonic_growth_retardation0.91111021
80MP0002086_abnormal_extraembryonic_tissu0.91082349
81MP0002080_prenatal_lethality0.89401997
82MP0002148_abnormal_hypersensitivity_rea0.88469541
83MP0002009_preneoplasia0.87040783
84MP0003566_abnormal_cell_adhesion0.86289352
85MP0005384_cellular_phenotype0.85615510
86MP0002088_abnormal_embryonic_growth/wei0.85199420
87MP0002405_respiratory_system_inflammati0.84510552
88MP0005058_abnormal_lysosome_morphology0.84129706
89MP0005220_abnormal_exocrine_pancreas0.84016959
90MP0002163_abnormal_gland_morphology0.83125998
91MP0002971_abnormal_brown_adipose0.82908956
92MP0001730_embryonic_growth_arrest0.81147261
93MP0002332_abnormal_exercise_endurance0.80419125
94MP0005670_abnormal_white_adipose0.78923770
95MP0005025_abnormal_response_to0.78471336
96MP0010678_abnormal_skin_adnexa0.77259228
97MP0000358_abnormal_cell_content/0.76215013
98MP0005584_abnormal_enzyme/coenzyme_acti0.74376874
99MP0001853_heart_inflammation0.73714590
100MP0000477_abnormal_intestine_morphology0.73554279

Predicted human phenotypes

RankGene SetZ-score
1Squamous cell carcinoma (HP:0002860)5.42922016
2Hemorrhage of the eye (HP:0011885)3.97856279
3Renal duplication (HP:0000075)3.93452130
4Gastrointestinal stroma tumor (HP:0100723)3.80024077
5Abnormality of pyrimidine metabolism (HP:0004353)3.40807965
6Malnutrition (HP:0004395)3.37366185
7Hyperacusis (HP:0010780)3.35527867
8Microvesicular hepatic steatosis (HP:0001414)3.25171650
9IgA deficiency (HP:0002720)3.19991968
10Ragged-red muscle fibers (HP:0003200)3.16992418
11Progressive muscle weakness (HP:0003323)3.15091288
12Colitis (HP:0002583)3.03870753
13Long palpebral fissure (HP:0000637)3.00212866
14Poikiloderma (HP:0001029)2.86626177
15Abnormality of glutamine family amino acid metabolism (HP:0010902)2.84158128
16Abnormality of glycolysis (HP:0004366)2.79151707
17Progressive external ophthalmoplegia (HP:0000590)2.78588215
18Dyschromatopsia (HP:0007641)2.74589569
19Distal lower limb amyotrophy (HP:0008944)2.72678276
20Flat cornea (HP:0007720)2.70283997
21Abnormality of the nasal septum (HP:0000419)2.61320306
22Insomnia (HP:0100785)2.53870973
23Sparse lateral eyebrow (HP:0005338)2.47396038
24Abnormality of placental membranes (HP:0011409)2.47050783
25Amniotic constriction ring (HP:0009775)2.47050783
26Emphysema (HP:0002097)2.45408346
27Milia (HP:0001056)2.40528202
28Breast hypoplasia (HP:0003187)2.32923378
29Popliteal pterygium (HP:0009756)2.25110903
30Abnormality of monocarboxylic acid metabolism (HP:0010996)2.24983692
31Rough bone trabeculation (HP:0100670)2.20172723
32Basal cell carcinoma (HP:0002671)2.19189908
33Abnormality of the intrinsic pathway (HP:0010989)2.17796802
34Cellulitis (HP:0100658)2.17178232
35Villous atrophy (HP:0011473)2.15132983
36Abnormality of small intestinal villus morphology (HP:0011472)2.15132983
37Chromosomal breakage induced by crosslinking agents (HP:0003221)2.15021958
38Progressive hearing impairment (HP:0001730)2.12594345
39Abnormal trabecular bone morphology (HP:0100671)2.12019284
40Hypertensive crisis (HP:0100735)2.09450390
41Agammaglobulinemia (HP:0004432)2.07831943
42Fatigue (HP:0012378)2.02326740
43Overriding aorta (HP:0002623)1.99708394
44Increased serum pyruvate (HP:0003542)1.99281878
45Chromsome breakage (HP:0040012)1.98986311
46Premature graying of hair (HP:0002216)1.98462239
47Cheilitis (HP:0100825)1.96545844
48Proximal placement of thumb (HP:0009623)1.94685250
49Abnormal hair laboratory examination (HP:0003328)1.94086400
50Deviation of the thumb (HP:0009603)1.92143232
51Ankyloglossia (HP:0010296)1.91189543
52Unilateral renal agenesis (HP:0000122)1.90085771
53Elfin facies (HP:0004428)1.89656671
54Cholecystitis (HP:0001082)1.89457782
55Abnormal gallbladder physiology (HP:0012438)1.89457782
56Broad face (HP:0000283)1.89018182
57Alkalosis (HP:0001948)1.88048750
58Lymphoma (HP:0002665)1.87291060
59Premature ovarian failure (HP:0008209)1.86931229
60Aplasia cutis congenita (HP:0001057)1.86374783
61Gastrointestinal inflammation (HP:0004386)1.86225123
62Testicular atrophy (HP:0000029)1.85493411
63Prominent nose (HP:0000448)1.84570841
64Focal segmental glomerulosclerosis (HP:0000097)1.83557477
65Lymphopenia (HP:0001888)1.83457992
66Rib fusion (HP:0000902)1.83326112
67IgM deficiency (HP:0002850)1.83249408
68Fragile skin (HP:0001030)1.83234720
69Choroideremia (HP:0001139)1.81737476
70Recurrent viral infections (HP:0004429)1.81270518
71Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.81173449
72Lip pit (HP:0100267)1.80342193
73Inflammation of the large intestine (HP:0002037)1.80278367
74Trismus (HP:0000211)1.80057578
75Upper limb amyotrophy (HP:0009129)1.79241166
76Distal upper limb amyotrophy (HP:0007149)1.79241166
77Abnormality of cells of the lymphoid lineage (HP:0012140)1.78483541
78Micronodular cirrhosis (HP:0001413)1.77892382
79Hepatitis (HP:0012115)1.77735531
80Ectopia lentis (HP:0001083)1.76752856
81Entropion (HP:0000621)1.76325697
82Progressive sensorineural hearing impairment (HP:0000408)1.75564635
83Elbow flexion contracture (HP:0002987)1.75067185
84Hyperammonemia (HP:0001987)1.72439424
85Recurrent sinusitis (HP:0011108)1.70565089
86Birth length less than 3rd percentile (HP:0003561)1.68389007
87Abnormality of the fingertips (HP:0001211)1.68143919
88Esophageal neoplasm (HP:0100751)1.67924715
89Neoplasm of head and neck (HP:0012288)1.67924715
90Reduced antithrombin III activity (HP:0001976)1.64993626
91Neonatal onset (HP:0003623)1.64066634
92Recurrent corneal erosions (HP:0000495)1.62391103
93Thin bony cortex (HP:0002753)1.62037847
94Impaired proprioception (HP:0010831)1.61837078
95Axonal loss (HP:0003447)1.61740983
96Abnormal ossification of hand bones (HP:0005921)1.61720967
97Viral hepatitis (HP:0006562)1.59858549
98Abnormality of the gastric mucosa (HP:0004295)1.58997414
99Leukopenia (HP:0001882)1.58753064
100Pili torti (HP:0003777)1.58444436

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.70459760
2ZAK3.99964757
3MST1R3.93291547
4ICK3.93023788
5EPHA23.60623928
6PDK23.48362914
7IRAK33.35238019
8STK162.76747476
9PIM22.69521822
10SMG12.55176884
11NME22.26092756
12EEF2K2.22036502
13ERN12.21719696
14SIK12.19733802
15CDK122.08950722
16PRPF4B1.93360924
17MAPK111.93267704
18MAP4K11.73356376
19TRIB31.61001859
20VRK11.55267371
21RPS6KA51.51287531
22TESK21.50649215
23TAOK21.47784500
24NME11.47011290
25LATS21.46300462
26MAP3K141.40263423
27MET1.39035073
28MAP3K131.09132229
29BUB11.05071897
30ARAF1.02817656
31FGFR41.01818371
32MTOR0.98732367
33MAP3K100.96874519
34IKBKB0.96242107
35SIK20.95981526
36AURKA0.88795555
37MAP3K110.86824960
38MAP3K90.86711656
39PDPK10.84493723
40PIM10.82073174
41NEK90.82070868
42MAP3K80.81983378
43CDC70.81454920
44CDK40.80711842
45RPS6KB20.79982737
46IRAK40.78165851
47RAF10.75241102
48LMTK20.73102169
49MAP2K20.69736191
50CHEK20.69641053
51MAP3K10.69602726
52STK240.68956053
53VRK20.68119653
54BRAF0.66963945
55BLK0.66121613
56AURKB0.65600830
57CDK60.64472390
58TBK10.64009972
59WEE10.60978205
60SIK30.57894803
61CDK80.56792452
62SRPK10.56319886
63CDK70.56279557
64AKT20.55308416
65TAOK10.53285350
66MAPKAPK50.52495106
67PDK10.50243757
68NEK10.50004120
69MELK0.49765392
70MAPKAPK30.45763314
71MAPK120.45268058
72WNK40.44503672
73CHUK0.44232192
74MAP2K30.43591987
75DAPK30.43226025
76PDGFRA0.42933006
77CHEK10.41250339
78CCNB10.40270124
79CDK90.37277709
80STK100.37224988
81MAP3K30.36614554
82ATR0.36044337
83PRKCI0.32398123
84NEK60.32197801
85NEK20.31557095
86RIPK40.31509872
87PKN20.31476135
88RPS6KL10.29672436
89RPS6KC10.29672436
90HIPK20.27840812
91PRKAA10.26826354
92RPS6KA10.26656345
93BCKDK0.24519656
94EIF2AK30.24363088
95IRAK20.24303275
96MAPK70.23893079
97TTK0.22779667
98PKN10.21015636
99BRD40.20875928
100PBK0.20492451

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053226.04168803
2Alcoholism_Homo sapiens_hsa050344.00549863
3Sulfur relay system_Homo sapiens_hsa041223.35792042
4DNA replication_Homo sapiens_hsa030302.84310633
5Fructose and mannose metabolism_Homo sapiens_hsa000512.77658131
6Viral carcinogenesis_Homo sapiens_hsa052032.41807084
7Biosynthesis of amino acids_Homo sapiens_hsa012302.36119277
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.18946073
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.02682516
10Arginine biosynthesis_Homo sapiens_hsa002201.88921118
11Folate biosynthesis_Homo sapiens_hsa007901.81370768
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.78290381
13Base excision repair_Homo sapiens_hsa034101.73367143
14Bladder cancer_Homo sapiens_hsa052191.64191475
15Pentose phosphate pathway_Homo sapiens_hsa000301.62371791
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57557238
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.45557358
18Mismatch repair_Homo sapiens_hsa034301.37272062
19B cell receptor signaling pathway_Homo sapiens_hsa046621.33878979
20Primary immunodeficiency_Homo sapiens_hsa053401.32190154
21Central carbon metabolism in cancer_Homo sapiens_hsa052301.31796268
22Carbon metabolism_Homo sapiens_hsa012001.28922234
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.27335407
24Cell cycle_Homo sapiens_hsa041101.26463484
25Allograft rejection_Homo sapiens_hsa053301.26259381
26Herpes simplex infection_Homo sapiens_hsa051681.21251486
27Galactose metabolism_Homo sapiens_hsa000521.20914930
28Small cell lung cancer_Homo sapiens_hsa052221.19942396
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17246693
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.15348002
31Graft-versus-host disease_Homo sapiens_hsa053321.15282815
32Chronic myeloid leukemia_Homo sapiens_hsa052201.13875578
33Influenza A_Homo sapiens_hsa051641.07824103
34One carbon pool by folate_Homo sapiens_hsa006701.06356569
35Apoptosis_Homo sapiens_hsa042101.03852195
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02220902
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02092530
38Ribosome_Homo sapiens_hsa030100.98830808
39Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98727118
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98563657
41Epstein-Barr virus infection_Homo sapiens_hsa051690.98153352
42Homologous recombination_Homo sapiens_hsa034400.96466838
43Fatty acid biosynthesis_Homo sapiens_hsa000610.95312136
44Nucleotide excision repair_Homo sapiens_hsa034200.93849464
45TNF signaling pathway_Homo sapiens_hsa046680.93471962
46Autoimmune thyroid disease_Homo sapiens_hsa053200.93441530
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92279998
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91456122
49Pyruvate metabolism_Homo sapiens_hsa006200.90014594
50Pyrimidine metabolism_Homo sapiens_hsa002400.88233828
51HTLV-I infection_Homo sapiens_hsa051660.84209442
52Hepatitis B_Homo sapiens_hsa051610.82661099
53Type I diabetes mellitus_Homo sapiens_hsa049400.82250639
54Thyroid cancer_Homo sapiens_hsa052160.81406356
55Asthma_Homo sapiens_hsa053100.79426956
56Phenylalanine metabolism_Homo sapiens_hsa003600.77353417
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77175143
58Viral myocarditis_Homo sapiens_hsa054160.76676362
59Toxoplasmosis_Homo sapiens_hsa051450.75606568
60Non-homologous end-joining_Homo sapiens_hsa034500.71564142
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.71491182
62Acute myeloid leukemia_Homo sapiens_hsa052210.70965505
63Pancreatic cancer_Homo sapiens_hsa052120.68972079
64Vitamin B6 metabolism_Homo sapiens_hsa007500.68350989
65Measles_Homo sapiens_hsa051620.67531260
66p53 signaling pathway_Homo sapiens_hsa041150.67218419
67Spliceosome_Homo sapiens_hsa030400.67088212
68RNA transport_Homo sapiens_hsa030130.67063857
69HIF-1 signaling pathway_Homo sapiens_hsa040660.65705972
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65527145
71MicroRNAs in cancer_Homo sapiens_hsa052060.64605643
72mTOR signaling pathway_Homo sapiens_hsa041500.64529911
73Leishmaniasis_Homo sapiens_hsa051400.64326142
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63722391
75Hepatitis C_Homo sapiens_hsa051600.63349176
76N-Glycan biosynthesis_Homo sapiens_hsa005100.62407226
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57954165
78Fanconi anemia pathway_Homo sapiens_hsa034600.57327822
79Other glycan degradation_Homo sapiens_hsa005110.55932570
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55640765
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.55130073
82Lysine degradation_Homo sapiens_hsa003100.54023062
83Legionellosis_Homo sapiens_hsa051340.52582093
84Non-small cell lung cancer_Homo sapiens_hsa052230.51922226
85mRNA surveillance pathway_Homo sapiens_hsa030150.49688470
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46774836
87Insulin resistance_Homo sapiens_hsa049310.44672696
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43150632
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.42369386
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37272126
91Antigen processing and presentation_Homo sapiens_hsa046120.35312022
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33797940
93Insulin signaling pathway_Homo sapiens_hsa049100.33308892
94VEGF signaling pathway_Homo sapiens_hsa043700.33237313
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33023132
96Prion diseases_Homo sapiens_hsa050200.32611165
97Osteoclast differentiation_Homo sapiens_hsa043800.32380436
98Notch signaling pathway_Homo sapiens_hsa043300.31794616
99RNA polymerase_Homo sapiens_hsa030200.29666947
100Fatty acid metabolism_Homo sapiens_hsa012120.28216301

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