C6ORF222

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)7.63790274
2epoxygenase P450 pathway (GO:0019373)6.71878834
3regulation of guanylate cyclase activity (GO:0031282)6.48145277
4intestinal absorption (GO:0050892)6.13164568
5regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.11998187
6fat-soluble vitamin biosynthetic process (GO:0042362)6.00867821
7transepithelial transport (GO:0070633)5.70285539
8oligosaccharide catabolic process (GO:0009313)5.59594173
9cobalamin metabolic process (GO:0009235)5.57675876
10calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)5.25034634
11digestion (GO:0007586)5.11412981
12sperm capacitation (GO:0048240)5.08367635
13positive regulation of guanylate cyclase activity (GO:0031284)5.04687018
14maintenance of gastrointestinal epithelium (GO:0030277)4.97829066
15regulation of systemic arterial blood pressure by hormone (GO:0001990)4.56668512
16regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.56668512
17endocrine process (GO:0050886)4.56668512
18fructose metabolic process (GO:0006000)4.55289638
19regulation of cellular extravasation (GO:0002691)4.52650732
20NADH metabolic process (GO:0006734)4.48331507
21peptide catabolic process (GO:0043171)4.42168392
22renal system process involved in regulation of blood volume (GO:0001977)4.28250493
23regulation of bile acid biosynthetic process (GO:0070857)4.10604739
24regulation of systemic arterial blood pressure (GO:0003073)4.02056331
25drug metabolic process (GO:0017144)4.01345140
26antibacterial humoral response (GO:0019731)3.98783093
27positive regulation of pseudopodium assembly (GO:0031274)3.89204227
28transcytosis (GO:0045056)3.86796278
29antimicrobial humoral response (GO:0019730)3.86245503
30regulation of cGMP biosynthetic process (GO:0030826)3.83924055
31cellular glucuronidation (GO:0052695)3.70118972
32hormone catabolic process (GO:0042447)3.69272872
33glucuronate metabolic process (GO:0019585)3.67078051
34uronic acid metabolic process (GO:0006063)3.67078051
35vitamin A metabolic process (GO:0006776)3.65274896
36lipoprotein transport (GO:0042953)3.65183218
37glycolipid catabolic process (GO:0019377)3.61081584
38peptide hormone processing (GO:0016486)3.60510968
39epithelial structure maintenance (GO:0010669)3.55808742
40digestive system process (GO:0022600)3.54063470
41omega-hydroxylase P450 pathway (GO:0097267)3.53058798
42regulation of pseudopodium assembly (GO:0031272)3.46884140
43diacylglycerol metabolic process (GO:0046339)3.46572137
44receptor guanylyl cyclase signaling pathway (GO:0007168)3.44655387
45regulation of RIG-I signaling pathway (GO:0039535)3.43427040
46positive regulation of glycoprotein biosynthetic process (GO:0010560)3.39510703
47very-low-density lipoprotein particle assembly (GO:0034379)3.36607608
48regulation of vitamin metabolic process (GO:0030656)3.27910931
49flavonoid metabolic process (GO:0009812)3.24474494
50actin filament depolymerization (GO:0030042)3.23661081
51regulation of apoptotic process involved in morphogenesis (GO:1902337)3.23372511
52alkaloid metabolic process (GO:0009820)3.20949498
53regulation of cholesterol homeostasis (GO:2000188)3.19742679
54regulation of triglyceride catabolic process (GO:0010896)3.17041963
55auditory receptor cell differentiation (GO:0042491)3.16629311
56intestinal cholesterol absorption (GO:0030299)3.16463285
57fat-soluble vitamin metabolic process (GO:0006775)3.16448396
58regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.16324310
59sexual reproduction (GO:0019953)3.15767146
60phospholipid scrambling (GO:0017121)3.12891257
61drug catabolic process (GO:0042737)3.11838710
62negative regulation of hormone metabolic process (GO:0032351)3.11251745
63bundle of His cell to Purkinje myocyte communication (GO:0086069)3.10285465
64renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.08874127
65regulation of cGMP metabolic process (GO:0030823)3.07823256
66sulfate transmembrane transport (GO:1902358)3.06822885
67glycosphingolipid catabolic process (GO:0046479)3.06175202
68adhesion of symbiont to host cell (GO:0044650)3.05556597
69virion attachment to host cell (GO:0019062)3.05556597
70positive regulation of glycoprotein metabolic process (GO:1903020)3.03276773
71nonribosomal peptide biosynthetic process (GO:0019184)3.00983481
72vitamin transport (GO:0051180)3.00744185
73glutathione biosynthetic process (GO:0006750)3.00631841
74pyrimidine-containing compound transmembrane transport (GO:0072531)3.00217906
75leukotriene metabolic process (GO:0006691)2.99174789
76bile acid and bile salt transport (GO:0015721)2.96499827
77nucleoside diphosphate biosynthetic process (GO:0009133)2.95809505
78vitamin biosynthetic process (GO:0009110)2.95788650
79ceramide catabolic process (GO:0046514)2.94620273
80plasma lipoprotein particle assembly (GO:0034377)2.91468196
81sphingomyelin metabolic process (GO:0006684)2.90631646
82NIK/NF-kappaB signaling (GO:0038061)2.88657377
83homocysteine metabolic process (GO:0050667)2.87439237
84positive regulation of cGMP biosynthetic process (GO:0030828)2.81576162
85urea cycle (GO:0000050)2.81261831
86urea metabolic process (GO:0019627)2.80895890
87arginine metabolic process (GO:0006525)2.79571063
88regulation of vasodilation (GO:0042312)2.79069655
89fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.78077935
90vitamin catabolic process (GO:0009111)2.76773360
91fat-soluble vitamin catabolic process (GO:0042363)2.76773360
92negative regulation of complement activation (GO:0045916)2.74774291
93high-density lipoprotein particle remodeling (GO:0034375)2.74206829
94O-glycan processing (GO:0016266)2.72376755
95sodium ion homeostasis (GO:0055078)2.71642719
96positive regulation of vasodilation (GO:0045909)2.70887033
97phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.69018281
98membrane lipid catabolic process (GO:0046466)2.68926314
99thrombin receptor signaling pathway (GO:0070493)2.67876037
100negative regulation of steroid metabolic process (GO:0045939)2.66906238

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human5.21621496
2GATA4_25053715_ChIP-Seq_YYC3_Human3.17849784
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.14404783
4SOX2_27498859_Chip-Seq_STOMACH_Mouse3.00688643
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.80797696
6FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.78846040
7HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.76816285
8GATA6_25053715_ChIP-Seq_YYC3_Human2.73414375
9SOX2_20726797_ChIP-Seq_SW620_Human2.69027146
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.55312744
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.45281636
12FOXO3_23340844_ChIP-Seq_DLD1_Human2.44353389
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.43292774
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38858067
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.29883629
16PPAR_26484153_Chip-Seq_NCI-H1993_Human2.22152120
17RXR_22158963_ChIP-Seq_LIVER_Mouse2.21962841
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.15269204
19TRIM28_21343339_ChIP-Seq_HEK293_Human2.09549066
20CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.08896240
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.08729074
22PPARA_22158963_ChIP-Seq_LIVER_Mouse2.03893427
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.90353113
24GATA1_22025678_ChIP-Seq_K562_Human1.86495504
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.77967583
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.76313163
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.75275490
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.74990084
29* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.66747062
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.66126722
31ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.63813814
32IRF8_22096565_ChIP-ChIP_GC-B_Human1.59374223
33BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.59012497
34CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.58072168
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46326269
36* FOXA2_19822575_ChIP-Seq_HepG2_Human1.46165351
37TCF4_18268006_ChIP-ChIP_LS174T_Human1.44539578
38* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.39992432
39CDX2_22108803_ChIP-Seq_LS180_Human1.39869108
40KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34417459
41KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28204987
42FOXA1_25552417_ChIP-Seq_VCAP_Human1.28135197
43GATA3_24758297_ChIP-Seq_MCF-7_Human1.27310479
44PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.26373742
45TP63_17297297_ChIP-ChIP_HaCaT_Human1.23511564
46* HNF4A_19822575_ChIP-Seq_HepG2_Human1.22652208
47NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.22511983
48ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22139197
49KLF5_25053715_ChIP-Seq_YYC3_Human1.21679119
50* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21411126
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21263801
52CEBPB_22108803_ChIP-Seq_LS180_Human1.20108055
53ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18760962
54NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15802822
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14627493
56* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.14598698
57P63_26484246_Chip-Seq_KERATINOCYTES_Human1.11970687
58* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.08857052
59CJUN_26792858_Chip-Seq_BT549_Human1.08157691
60SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05689590
61RACK7_27058665_Chip-Seq_MCF-7_Human1.04481469
62RUNX1_27514584_Chip-Seq_MCF-7_Human1.04284539
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.03226449
64NANOG_20526341_ChIP-Seq_ESCs_Human1.00453161
65RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98292350
66PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96407887
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95186748
68* GATA2_19941826_ChIP-Seq_K562_Human0.93587172
69FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.93454160
70AHR_22903824_ChIP-Seq_MCF-7_Human0.91702774
71LXR_22292898_ChIP-Seq_THP-1_Human0.91152993
72BCOR_27268052_Chip-Seq_Bcells_Human0.90975290
73PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90537087
74TP63_23658742_ChIP-Seq_EP156T_Human0.90082360
75STAT1_20625510_ChIP-Seq_HELA_Human0.89107700
76BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.86794026
77SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.85645365
78SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.85645365
79BCL6_27268052_Chip-Seq_Bcells_Human0.85193312
80Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82176978
81P300_27268052_Chip-Seq_Bcells_Human0.81020731
82* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.80401709
83CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80247597
84JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79971444
85JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77953380
86TAF2_19829295_ChIP-Seq_ESCs_Human0.77773081
87ARNT_22903824_ChIP-Seq_MCF-7_Human0.77565291
88SA1_27219007_Chip-Seq_Bcells_Human0.76337273
89SMAD_19615063_ChIP-ChIP_OVARY_Human0.75599472
90FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75038307
91RXR_22108803_ChIP-Seq_LS180_Human0.73268320
92HIF1A_21447827_ChIP-Seq_MCF-7_Human0.72833327
93CTCF_27219007_Chip-Seq_Bcells_Human0.72721544
94FOXA1_25329375_ChIP-Seq_VCAP_Human0.72695925
95FOXA1_27270436_Chip-Seq_PROSTATE_Human0.72695925
96AUTS2_25519132_ChIP-Seq_293T-REX_Human0.72544500
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71686611
98TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71644701
99SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.71607498
100TP63_22573176_ChIP-Seq_HFKS_Human0.70459523

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.32567675
2MP0002139_abnormal_hepatobiliary_system4.94509167
3MP0003300_gastrointestinal_ulcer4.66697290
4MP0001666_abnormal_nutrient_absorption4.55604055
5MP0002138_abnormal_hepatobiliary_system3.92012707
6MP0009840_abnormal_foam_cell3.73652454
7MP0005085_abnormal_gallbladder_physiolo3.65667582
8MP0005365_abnormal_bile_salt3.45039459
9MP0010386_abnormal_urinary_bladder3.11726514
10MP0003183_abnormal_peptide_metabolism2.94984240
11MP0010234_abnormal_vibrissa_follicle2.94269754
12MP0002132_abnormal_respiratory_system2.74978029
13MP0002163_abnormal_gland_morphology2.74961691
14MP0004019_abnormal_vitamin_homeostasis2.51801720
15MP0008004_abnormal_stomach_pH2.50878132
16MP0004264_abnormal_extraembryonic_tissu2.46728748
17MP0001664_abnormal_digestion2.35894068
18MP0005670_abnormal_white_adipose2.16901715
19MP0010155_abnormal_intestine_physiology2.14836622
20MP0003866_abnormal_defecation2.12470010
21MP0002876_abnormal_thyroid_physiology2.00415539
22MP0010329_abnormal_lipoprotein_level2.00017819
23MP0000462_abnormal_digestive_system1.92048092
24MP0003868_abnormal_feces_composition1.87555932
25MP0003252_abnormal_bile_duct1.87386951
26MP0005410_abnormal_fertilization1.80779135
27MP0010352_gastrointestinal_tract_polyps1.80195878
28MP0003724_increased_susceptibility_to1.79151689
29MP0002277_abnormal_respiratory_mucosa1.76648346
30MP0001873_stomach_inflammation1.76265761
31MP0009379_abnormal_foot_pigmentation1.71726252
32MP0000538_abnormal_urinary_bladder1.70132084
33MP0005166_decreased_susceptibility_to1.69879068
34MP0004147_increased_porphyrin_level1.67029768
35MP0008872_abnormal_physiological_respon1.63496783
36MP0009643_abnormal_urine_homeostasis1.55345102
37MP0005379_endocrine/exocrine_gland_phen1.51668717
38MP0005332_abnormal_amino_acid1.46886950
39MP0002089_abnormal_postnatal_growth/wei1.46092931
40MP0001765_abnormal_ion_homeostasis1.38052077
41MP0000490_abnormal_crypts_of1.33689232
42MP0000477_abnormal_intestine_morphology1.30733483
43MP0001663_abnormal_digestive_system1.29616840
44MP0004043_abnormal_pH_regulation1.27778604
45MP0002822_catalepsy1.21701028
46MP0005220_abnormal_exocrine_pancreas1.17882973
47MP0002118_abnormal_lipid_homeostasis1.13521353
48MP0005058_abnormal_lysosome_morphology1.12780223
49MP0001756_abnormal_urination1.12450265
50MP0005636_abnormal_mineral_homeostasis1.11059060
51MP0009785_altered_susceptibility_to1.08890851
52MP0001485_abnormal_pinna_reflex1.07148300
53MP0002136_abnormal_kidney_physiology1.06217997
54MP0004858_abnormal_nervous_system1.04553638
55MP0008875_abnormal_xenobiotic_pharmacok1.04288734
56MP0005409_darkened_coat_color1.00568548
57MP0003879_abnormal_hair_cell1.00486151
58MP0000678_abnormal_parathyroid_gland1.00431460
59MP0005084_abnormal_gallbladder_morpholo0.99455860
60MP0004782_abnormal_surfactant_physiolog0.99323484
61MP0005381_digestive/alimentary_phenotyp0.98382629
62MP0000613_abnormal_salivary_gland0.98153122
63MP0003436_decreased_susceptibility_to0.96117660
64MP0005448_abnormal_energy_balance0.93371087
65MP0002796_impaired_skin_barrier0.92535419
66MP0000609_abnormal_liver_physiology0.91867994
67MP0001764_abnormal_homeostasis0.89289982
68MP0001845_abnormal_inflammatory_respons0.88986643
69MP0005319_abnormal_enzyme/_coenzyme0.84801837
70MP0009764_decreased_sensitivity_to0.83003580
71MP0002928_abnormal_bile_duct0.80576538
72MP0005083_abnormal_biliary_tract0.80289556
73MP0003718_maternal_effect0.79729035
74MP0005310_abnormal_salivary_gland0.79397010
75MP0005025_abnormal_response_to0.75317393
76MP0005584_abnormal_enzyme/coenzyme_acti0.74530492
77MP0003045_fibrosis0.72725760
78MP0009115_abnormal_fat_cell0.69817159
79MP0003950_abnormal_plasma_membrane0.68695615
80MP0008469_abnormal_protein_level0.68093950
81MP0005023_abnormal_wound_healing0.66542415
82MP0000249_abnormal_blood_vessel0.65034838
83MP0002971_abnormal_brown_adipose0.62222345
84MP0005666_abnormal_adipose_tissue0.62211091
85MP0001533_abnormal_skeleton_physiology0.61760289
86MP0000230_abnormal_systemic_arterial0.60335601
87MP0002006_tumorigenesis0.59933072
88MP0002166_altered_tumor_susceptibility0.59653350
89MP0002098_abnormal_vibrissa_morphology0.58062701
90MP0001501_abnormal_sleep_pattern0.57679827
91MP0005334_abnormal_fat_pad0.57123141
92MP0009765_abnormal_xenobiotic_induced0.56150304
93MP0005451_abnormal_body_composition0.55312593
94MP0004947_skin_inflammation0.54519685
95MP0009642_abnormal_blood_homeostasis0.54207429
96MP0005165_increased_susceptibility_to0.53567790
97MP0003953_abnormal_hormone_level0.53296005
98MP0001790_abnormal_immune_system0.51164977
99MP0005387_immune_system_phenotype0.51164977
100MP0005501_abnormal_skin_physiology0.50850410

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)8.59062664
2Abnormality of glutamine family amino acid metabolism (HP:0010902)7.87821086
3Exocrine pancreatic insufficiency (HP:0001738)6.36932324
4Malnutrition (HP:0004395)5.95943917
5Abnormality of proline metabolism (HP:0010907)5.93845658
6Hydroxyprolinuria (HP:0003080)5.93845658
7Rectal prolapse (HP:0002035)5.55416065
8Fat malabsorption (HP:0002630)5.23688054
9Steatorrhea (HP:0002570)4.76671670
10Abnormality of chloride homeostasis (HP:0011422)4.39955770
11Male infertility (HP:0003251)4.28389322
12Vacuolated lymphocytes (HP:0001922)4.12051280
13Systemic lupus erythematosus (HP:0002725)4.06152307
14Abnormality of the vitamin B12 metabolism (HP:0004341)3.87209094
15Chronic diarrhea (HP:0002028)3.84581189
16Glycosuria (HP:0003076)3.67832189
17Abnormality of urine glucose concentration (HP:0011016)3.67832189
18Abnormality of vitamin B metabolism (HP:0004340)3.66616747
19Gout (HP:0001997)3.58352414
20Congenital sensorineural hearing impairment (HP:0008527)3.54795185
21Abnormality of the right ventricle (HP:0001707)3.48892705
22Widely patent fontanelles and sutures (HP:0004492)3.46771272
23Potter facies (HP:0002009)3.39685789
24Facial shape deformation (HP:0011334)3.39685789
25Increased purine levels (HP:0004368)3.38183531
26Hyperuricemia (HP:0002149)3.38183531
27Abnormal biliary tract morphology (HP:0012440)3.32807272
28Azoospermia (HP:0000027)3.32261187
29Abnormal pancreas size (HP:0012094)3.31660757
30Hypobetalipoproteinemia (HP:0003563)3.13313130
31Gastrointestinal dysmotility (HP:0002579)3.09451072
32Right ventricular cardiomyopathy (HP:0011663)3.02618753
33Xanthomatosis (HP:0000991)3.01070850
34Abnormality of vitamin metabolism (HP:0100508)2.97137624
35Confusion (HP:0001289)2.88386820
36Hyperactive renin-angiotensin system (HP:0000841)2.88050991
37Abnormality of purine metabolism (HP:0004352)2.74057244
38Late onset (HP:0003584)2.73396837
39Pancreatitis (HP:0001733)2.69080737
40Abnormality of monocarboxylic acid metabolism (HP:0010996)2.68938802
41Acanthocytosis (HP:0001927)2.66192972
42Abdominal distention (HP:0003270)2.63708057
43Hyperglycinuria (HP:0003108)2.62187750
44Curly hair (HP:0002212)2.58972031
45Decreased circulating renin level (HP:0003351)2.58549257
46Glomerulonephritis (HP:0000099)2.55160139
47Abnormal glucose tolerance (HP:0001952)2.52723826
48Thin bony cortex (HP:0002753)2.51583012
49Nausea (HP:0002018)2.49780536
50Recurrent pneumonia (HP:0006532)2.49587927
51Abnormality of small intestinal villus morphology (HP:0011472)2.40968066
52Villous atrophy (HP:0011473)2.40968066
53Abnormality of nucleobase metabolism (HP:0010932)2.40463661
54Enlarged epiphyses (HP:0010580)2.39210319
55Dehydration (HP:0001944)2.38011310
56Metabolic alkalosis (HP:0200114)2.37248452
57Proximal tubulopathy (HP:0000114)2.35802912
58Abnormality of macrophages (HP:0004311)2.35512630
59Wide cranial sutures (HP:0010537)2.35004058
60Hyperammonemia (HP:0001987)2.31645652
61Abnormality of renin-angiotensin system (HP:0000847)2.31383933
62Nephrolithiasis (HP:0000787)2.30462080
63Focal segmental glomerulosclerosis (HP:0000097)2.29334497
64Hypophosphatemia (HP:0002148)2.27071919
65Hypercalciuria (HP:0002150)2.26135947
66Hyperphosphatemia (HP:0002905)2.26005025
67Pigmentary retinal degeneration (HP:0001146)2.24793416
68Abnormality of glycine metabolism (HP:0010895)2.19891611
69Abnormality of serine family amino acid metabolism (HP:0010894)2.19891611
70Hyperparathyroidism (HP:0000843)2.19464509
71Abnormal spermatogenesis (HP:0008669)2.17179304
72Hyperphosphaturia (HP:0003109)2.15128012
73Hypoplasia of the uterus (HP:0000013)2.13565863
74Hypoproteinemia (HP:0003075)2.13207023
75Alkalosis (HP:0001948)2.10796255
76Abnormality of aspartate family amino acid metabolism (HP:0010899)2.07607319
77Megaloblastic anemia (HP:0001889)2.06962964
78Renal tubular acidosis (HP:0001947)2.06798308
79Abnormal urine phosphate concentration (HP:0012599)2.05506479
80Hypotension (HP:0002615)2.01850237
81Dysostosis multiplex (HP:0000943)1.99160402
82Metabolic acidosis (HP:0001942)1.97612034
83Hemorrhage of the eye (HP:0011885)1.97225009
84Posterior subcapsular cataract (HP:0007787)1.96681261
85Protuberant abdomen (HP:0001538)1.92091939
86Nephritis (HP:0000123)1.92043937
87Abnormality of the costochondral junction (HP:0000919)1.91955751
88Delayed CNS myelination (HP:0002188)1.91835099
89Complement deficiency (HP:0004431)1.90963688
90Glomerulosclerosis (HP:0000096)1.89940589
91Ankle clonus (HP:0011448)1.89541493
92Abnormality of sulfur amino acid metabolism (HP:0004339)1.89411993
93Symptomatic seizures (HP:0011145)1.83455416
94Delayed epiphyseal ossification (HP:0002663)1.80380827
95Abnormality of complement system (HP:0005339)1.80328174
96Insulin resistance (HP:0000855)1.79665541
97Hypolipoproteinemia (HP:0010981)1.78499909
98Abnormality of magnesium homeostasis (HP:0004921)1.78382185
99Abnormality of alkaline phosphatase activity (HP:0004379)1.76015840
100Alopecia of scalp (HP:0002293)1.75997186

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKG23.98905084
2STK243.72060810
3EPHA23.43884545
4ACVR1B3.16876469
5MST1R2.97872212
6STK38L2.85832679
7MAP3K122.41329679
8STK392.18011919
9LMTK212.1231411
10RIPK11.93998044
11ERN11.86682591
12PDK21.74204343
13OXSR11.72421683
14TNIK1.63992252
15FGFR41.27265412
16MAP3K31.21476371
17NLK1.13456910
18MYLK1.03833416
19STK30.99389258
20INSRR0.99209002
21MET0.95469625
22EPHA30.93083410
23MAP4K20.92519115
24TESK10.92357066
25PIK3CA0.87199176
26MAPK110.86363131
27GRK10.85030836
28TESK20.82409960
29DDR20.81954363
30MAP3K100.79053934
31MST40.79027441
32EPHB20.77298959
33BMPR20.75174620
34FER0.72387585
35GRK60.69455993
36PTK60.67620561
37PTK20.66438749
38ROCK10.66070522
39MAP3K20.62427393
40NEK60.58007945
41EPHB10.57723689
42MAP2K20.54736616
43MAP3K10.54415893
44ICK0.54205799
45ERBB20.52515635
46STK380.52221329
47FGFR30.49459310
48PRKCQ0.48592347
49TYK20.48510670
50PDPK10.46227108
51MAP3K140.45707132
52PAK40.44687950
53ERBB30.37183084
54PRKAA20.36916057
55MAP2K60.36523141
56RIPK40.35724811
57PASK0.35498606
58CASK0.35226624
59PRKACG0.33701606
60PRKAA10.33569141
61FRK0.33557870
62PDK10.31045656
63TEC0.29888854
64PRKCA0.29861637
65DAPK20.27443757
66IKBKB0.26986621
67HIPK20.26030320
68PRKCD0.26003514
69MAPK70.25567973
70MELK0.25001270
71MAP3K110.24862963
72MAPKAPK30.24853785
73IRAK10.24796704
74JAK10.24640712
75ITK0.24019765
76EPHA40.21508455
77DAPK10.21493809
78AKT30.21091126
79SRC0.19315317
80PRKCE0.18856163
81MATK0.16646122
82EIF2AK30.15888990
83BCR0.15491029
84IGF1R0.15145370
85PRKG10.14627383
86YES10.14438666
87DYRK1B0.14003142
88IKBKE0.13512712
89TBK10.12859061
90CDC42BPA0.12823581
91PRKCZ0.11751908
92ZAP700.10140213
93RPS6KA20.10125386
94DMPK0.10093696
95EEF2K0.09756258
96CHUK0.09323034
97TAOK10.08719745
98MAP4K10.08210871
99DAPK30.07504441
100CAMK2D0.06784063

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049754.39765089
2Cyanoamino acid metabolism_Homo sapiens_hsa004604.31764181
3Vitamin digestion and absorption_Homo sapiens_hsa049773.62865373
4Renin-angiotensin system_Homo sapiens_hsa046143.29078847
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.23970792
6Protein digestion and absorption_Homo sapiens_hsa049742.88149898
7Mineral absorption_Homo sapiens_hsa049782.59204074
8Pancreatic secretion_Homo sapiens_hsa049722.40541786
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.29355556
10Sulfur metabolism_Homo sapiens_hsa009202.09889408
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.05561453
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.00966475
13Fructose and mannose metabolism_Homo sapiens_hsa000512.00055333
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.94835047
15Starch and sucrose metabolism_Homo sapiens_hsa005001.94474802
16Caffeine metabolism_Homo sapiens_hsa002321.89164939
17Bile secretion_Homo sapiens_hsa049761.87756120
18Arginine biosynthesis_Homo sapiens_hsa002201.81312063
19Retinol metabolism_Homo sapiens_hsa008301.80518501
20Linoleic acid metabolism_Homo sapiens_hsa005911.78204861
21Glycerolipid metabolism_Homo sapiens_hsa005611.77217678
22Chemical carcinogenesis_Homo sapiens_hsa052041.76886002
23Carbohydrate digestion and absorption_Homo sapiens_hsa049731.74098040
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.73225654
25Histidine metabolism_Homo sapiens_hsa003401.67115003
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.65675894
27Galactose metabolism_Homo sapiens_hsa000521.65424563
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.62172425
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.59855953
30Other glycan degradation_Homo sapiens_hsa005111.52865118
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.44204791
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.38926062
33Arachidonic acid metabolism_Homo sapiens_hsa005901.37526872
34Tryptophan metabolism_Homo sapiens_hsa003801.34501192
35Fatty acid degradation_Homo sapiens_hsa000711.34356529
36PPAR signaling pathway_Homo sapiens_hsa033201.30231886
37Sphingolipid metabolism_Homo sapiens_hsa006001.22536363
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.20710065
39Arginine and proline metabolism_Homo sapiens_hsa003301.20467580
40Glutathione metabolism_Homo sapiens_hsa004801.00466700
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98145713
42Ether lipid metabolism_Homo sapiens_hsa005650.97430742
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95636315
44Butanoate metabolism_Homo sapiens_hsa006500.94034867
45ABC transporters_Homo sapiens_hsa020100.87788013
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86888680
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83986176
48Vibrio cholerae infection_Homo sapiens_hsa051100.79445196
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72123342
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.72116437
51Glycerophospholipid metabolism_Homo sapiens_hsa005640.71507534
52Tight junction_Homo sapiens_hsa045300.70490122
53Hepatitis C_Homo sapiens_hsa051600.69315766
54Fatty acid biosynthesis_Homo sapiens_hsa000610.65690142
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65601081
56Fatty acid metabolism_Homo sapiens_hsa012120.64347812
57Pentose phosphate pathway_Homo sapiens_hsa000300.64018797
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56596593
59Thyroid hormone synthesis_Homo sapiens_hsa049180.54100950
60Asthma_Homo sapiens_hsa053100.50943529
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.50537647
62Phenylalanine metabolism_Homo sapiens_hsa003600.47232144
63Complement and coagulation cascades_Homo sapiens_hsa046100.46988833
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46667861
65Pertussis_Homo sapiens_hsa051330.45528309
66Staphylococcus aureus infection_Homo sapiens_hsa051500.42801521
67Peroxisome_Homo sapiens_hsa041460.40989100
68Allograft rejection_Homo sapiens_hsa053300.39542032
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37749870
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.37204251
71Autoimmune thyroid disease_Homo sapiens_hsa053200.35892684
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35628629
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.35556138
74Type I diabetes mellitus_Homo sapiens_hsa049400.35039353
75Graft-versus-host disease_Homo sapiens_hsa053320.33090620
76Influenza A_Homo sapiens_hsa051640.32243923
77Dorso-ventral axis formation_Homo sapiens_hsa043200.32171063
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.29373309
79Folate biosynthesis_Homo sapiens_hsa007900.28732356
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27588753
81Rheumatoid arthritis_Homo sapiens_hsa053230.25814012
82Carbon metabolism_Homo sapiens_hsa012000.25333677
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.24682440
84Fatty acid elongation_Homo sapiens_hsa000620.23804442
85beta-Alanine metabolism_Homo sapiens_hsa004100.23365589
86TNF signaling pathway_Homo sapiens_hsa046680.23339715
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.22321227
88African trypanosomiasis_Homo sapiens_hsa051430.21639185
89Metabolic pathways_Homo sapiens_hsa011000.21372208
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.19555896
91Insulin resistance_Homo sapiens_hsa049310.18616182
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.17755198
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.14940079
94Chemokine signaling pathway_Homo sapiens_hsa040620.12402586
95Tyrosine metabolism_Homo sapiens_hsa003500.11720967
96Propanoate metabolism_Homo sapiens_hsa006400.11425544
97Gastric acid secretion_Homo sapiens_hsa049710.09361384
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.07902659
99AMPK signaling pathway_Homo sapiens_hsa041520.07590577
100Leishmaniasis_Homo sapiens_hsa051400.07100786

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